1,430 results match your criteria Pediatrics Gastrointestinal Bleeding


Retrospective Review of Secondary Prevention Strategies for Gastrointestinal Bleeding and Associated Clinical Outcomes in Left Ventricular Assist Device Patients.

Artif Organs 2022 May 16. Epub 2022 May 16.

Pharmacy Department, University of Kentucky Medical Center, Lexington, KY, USA.

Background: Gastrointestinal bleeding (GIB) is one of the most common bleeding complications associated with Left Ventricular Assist Devices (LVAD). Currently, there is no strong evidence or clear guidance for which secondary GIB prophylaxis strategy should be implemented after the discontinuation of aspirin.

Methods: Our single-center study describes the outcomes of 26 LVAD patients who experienced a total of 49 GIB events, these individuals were either in Group-1) lower INR target range or Group-2) lower INR target plus a hemostatic agent as the secondary prophylaxis strategy. Read More

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Age Related Characteristics Of Children And Adolescent With Henoch Schönlein Purpura And Systems Involvement: An Experience From Tertiary Care Center.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):336-340

Department of Paediatrics Aga Khan University Hospital Karachi, Pakistan.

Background: Henoch-Schönlein Purpura (HSP) is the most common vasculitis among children and adolescent characterized by skin, joints, renal and gastrointestinal involvement. There is different presenting feature of Henoch-Schönlein Purpura (HSP) and systemic involvement may vary at a certain age group.

Methods: This was a ten-year retrospective cohort study done at a tertiary care hospital of Pakistan conducted from 2011-2020. Read More

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Efficacy of intravenous propranolol for life-threatening diffuse neonatal hemangiomatosis.

Pediatr Dermatol 2022 May 16. Epub 2022 May 16.

Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Oral propranolol is recommended as the first-line agent for infantile hemangioma requiring systemic treatment. Life-threatening complications such as obstructive infantile hemangioma of the airway or infantile hepatic hemangioma associated with high-output congestive heart failure are major indications for the consideration of early treatment. We present the case of an infant with life-threatening diffuse neonatal hemangiomatosis, including airway obstruction due to subglottic hemangioma, heart failure due to multiple hepatic hemangiomas with portohepatic venous shunts, and severe anemia due to continuous gastrointestinal bleeding, in which treatment with intravenous propranolol proved successful. Read More

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A Rare Case of a Translocation-Associated Perivascular Epithelioid Cell Neoplasm (PEComa).

Case Rep Pediatr 2022 21;2022:7519456. Epub 2022 Apr 21.

Monmouth Gastroenterology, Monmouth Medical Center, Long Branch, NJ 07740, USA.

A perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm composed of perivascular epithelioid cells with distinctive histologic, immunohistochemical, and genetic features. PEComas arising from various anatomical sites have been reported, but gastrointestinal PEComas are extremely rare entities. Here, we discuss the clinical and pathological features of a gastrointestinal PEComa with a transcription factor E3 (TFE3) translocation in a 17-year old adolescent male with a clinical presentation of abdominal pain and gastrointestinal bleeding. Read More

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Clinical Characteristics of Pediatric Patients with Congenital Erythrocytosis: A Single-Center Study.

Indian J Hematol Blood Transfus 2022 Apr 25;38(2):366-372. Epub 2021 Aug 25.

Division of Pediatric Hematology, Department of Pediatrics, Kocaeli University, Umuttepe, 41380 Kocaeli, Turkey.

Although congenital erythrocytosis (CE), an inherited disorder, impairs pediatric quality of life, physicians often overlook high hemoglobin (Hgb) levels and its symptoms due to lack of knowledge of age-adjusted pediatric Hgb levels and CE's rarity. In a retrospective, single-center study, data from hospital records of pediatric patients diagnosed with CE were evaluated. Twenty-six patients from 25 families (80. Read More

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Hematemesis in Infants: The First Evidence-Based Score to Predict the Need for Timely Endoscopy.

Pediatr Emerg Care 2022 May 23;38(5):e1245-e1250. Epub 2021 Dec 23.

Division of Neurogastroenterology and Motility, Department of Paediatric Gastroenterology, UCL Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom.

Objectives: Infantile acute upper gastrointestinal bleeding involves a decision for therapeutic intervention that most pediatricians first coming into contact with the patient are, not unreasonably, unable to objectively provide. Therefore, some objective tools of individual risk assessment would seem to be crucial. The principal aim of the present study was to investigate the anamnestic and clinical parameters of infants with hematemesis, together with laboratory and instrumental findings, to create a scoring system that may help identify those infants requiring an appropriate and timely application of upper gastrointestinal (GI) endoscopy. Read More

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Egyptian revalidation of non-invasive parameters for predicting esophageal varices in cirrhotic patients: A retrospective study.

Arab J Gastroenterol 2022 Apr 23. Epub 2022 Apr 23.

National Committee for Control of Viral Hepatitis, Egypt; Endemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Study Aims: In resource-limited countries, non-invasive tests for assessing liver fibrosis are a potential alternative to costly endoscopic screening for esophageal varices. We aimed to validate several non-invasive parameters for predicting the presence of varices.

Patients And Methods: Between September 2006 and August 2017, a total of 46,014 patients who underwent upper gastrointestinal endoscopy as one of the perquisites for receiving hepatitis C virus (HCV) therapy were enrolled and divided into group I (without varices) and group II (with varices). Read More

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Gastrointestinal Kohlmeier-Degos disease: a narrative review.

Orphanet J Rare Dis 2022 04 20;17(1):172. Epub 2022 Apr 20.

Department of Surgery, Henry Ford Health System, Detroit, MI, USA.

Introduction: Kohlmeier-Degos (K-D) disease is a rare obliterative vasculopathy that can present as a benign cutaneous form or with potentially malignant systemic involvement. The gastrointestinal tract is most frequently involved in systemic disease and mortality is often related to bowel perforations. Herein, we provide information to providers and patients regarding gastrointestinal K-D symptomology, pathology, treatment, and diagnosis, with a focus on the importance of timely diagnostic laparoscopy. Read More

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[Single Center Clinical Analysis of Bloodstream Infection Pathogens in Children with Acute Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2022 Apr;30(2):357-360

Department of Pediatrics, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.

Objective: To investigate the clinical features, distribution of pathogenic bacteria, and drug resistance of bloodstream infection in children with acute leukemia.

Methods: Clinical data of 93 blood culture-positive children with acute leukemia from January 2015 to December 2019 in Department of Pediatrics, The Second Hospital of Anhui Medical University were analyzed retrospectively.

Results: In these 93 cases, 78 cases were in the period of neutrophil deficiency. Read More

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A challenging case of COVID-19: a COVID-19 positive adolescent presented with severe diabetic ketoacidosis, resistant hypertension.

BMC Endocr Disord 2022 Apr 5;22(1):90. Epub 2022 Apr 5.

Department of Pediatrics, School of Medicine, Emam Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus which causes COVID-19. It binds to the angiotensin-converting enzyme 2 (ACE2) receptors, expressed in key metabolic organs and tissues, including pancreatic beta cells, adipose tissue, the small intestine, and kidneys. This condition has been linked to a variety of additional symptoms, including acute encephalopathy, changes in consciousness, and even gastrointestinal bleeding. Read More

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Therapeutic endoscopy of a Dieulafoy lesion in a 10-year-old girl: A case report.

World J Clin Cases 2022 Feb;10(6):1966-1972

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Background: There are multiple causes of sudden gastrointestinal bleeding in children. Reports of Dieulafoy lesions (DLs) in children are scarce. DLs can be fatal without appropriate treatment. Read More

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February 2022

Meckel's Diverticulum, A Rare Presentation in a Neonate.

Am Surg 2022 Mar 18:31348211060431. Epub 2022 Mar 18.

25063Metropolitan Hospital, New York, NY, USA.

Meckel's diverticulum is commonly symptomatic the first 2 years of life. Complications associated with Meckel's diverticulum are due to gastrointestinal (GI) bleeding or obstruction. A 5-day-old male presented to the emergency department (ED) with an episode of bright red blood per rectum (BRBPR) associated with emesis. Read More

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Coats Plus syndrome: a diagnostic and therapeutic challenge in pediatric gastrointestinal hemorrhage.

Turk J Pediatr 2022 ;64(1):166-170

Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

Background: Cerebroretinal microangiopathy with calcifications and cysts formerly known as Coats plus syndrome is a rare multisystemic autosomal recessive disease that affects the eyes, brain, bone, and gastrointestinal system. Intestinal telangiectasia are components of vascular malformations characterized by gastrointestinal system bleedings. Recurrent gastrointestinal system bleedings have been reported as being due to hepatic failure or vascular malformations of the gastrointestinal system tract. Read More

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One-year incidence of venous thromboembolism, bleeding, and death in patients with solid tumors newly initiating cancer treatment: Results from the Cancer-VTE Registry.

Thromb Res 2022 May 21;213:203-213. Epub 2021 Sep 21.

Department of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan. Electronic address:

Introduction: Although many publications have reported the incidence of venous thromboembolism (VTE) in patients with cancer from Western countries, to date, no prospective East Asian studies have been published, and potential racial differences remain unclear. The multicenter, prospective, observational Cancer-VTE Registry aimed to clarify the incidence of VTE and bleeding and identify risk factors in Japanese patients with solid tumors after one year of follow-up.

Materials And Methods: Patients with colorectal, lung, stomach, pancreatic, breast, or gynecologic cancer were enrolled after VTE screening and before starting cancer treatment. Read More

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Therapeutic Upper Gastrointestinal Endoscopy in Pediatric Gastroenterology.

Front Pediatr 2021 25;9:715912. Epub 2022 Feb 25.

Pediatric Gastroenterology, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, United Kingdom.

This paper seeks to give a broad overview of pediatric upper gastrointestinal (GI) pathologies that we are now able to treat endoscopically, acquired or congenital, and we hope this delivers the reader an impression of what is increasingly available to pediatric endoscopists and their patients. Read More

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February 2022

Successful Management of a Case of Intestinal Behçet's Disease with a Splenic Abscess by Intensified Immunosuppressive Therapy Without Splenectomy.

Mod Rheumatol Case Rep 2022 Mar 11. Epub 2022 Mar 11.

Department of Pediatrics, Graduate School of Medicine, Chiba University, Japan.

Behçet's disease (BD) is often associated with neutrophilic dermatosis. However, BD is rarely associated with aseptic abscesses in the spleen or liver. A 2-year-old girl presented to our hospital with a two-week history of fever, abdominal pain, and a skin ulcer on her leg. Read More

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Hypercoagulopathy in Overweight and Obese COVID-19 Patients: a Single-Center Case Series.

J Crit Care Med (Targu Mures) 2022 Jan 13;8(1):41-48. Epub 2021 Nov 13.

Larkin Health System, South Miami, FL, USA.

A case series is presented of five overweight or obese patients with confirmed coronavirus disease 2019 (COVID-19) in South Miami, Florida, United States. A multitude of coagulation parameters was suggestive of a hypercoagulable state among the hospitalized COVID-19 patients. This article reports various manifestations of hypercoagulable states in overweight and obese patients, such as overt bleeding consistent with disseminated intravascular coagulation, venous thromboembolism, gastrointestinal bleeding as well as retroperitoneal hematoma. Read More

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January 2022

Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia.

Hepatology 2022 Mar 10. Epub 2022 Mar 10.

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.

Background And Aims: The natural history of gastroesophageal variceal hemorrhage (VH) in biliary atresia (BA) is not well characterized. We analyzed risk factors, incidence, and outcomes of VH in a longitudinal multicenter study.

Approach And Results: Participants enrolled in either an incident (Prospective Database of Infants with Cholestasis [PROBE]) or prevalent (Biliary Atresia Study of Infants and Children [BASIC]) cohort of BA were included. Read More

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GIST presenting as refractory iron-deficiency anaemia in paediatric patient.

BMJ Case Rep 2022 Mar 9;15(3). Epub 2022 Mar 9.

Department of Radiology, Sheikh Khalifa Medical City, Abu Dhabi, UAE.

Gastrointestinal stromal tumours (GISTs) are very rare gastrointestinal (GI) mesenchymal tumours affecting only 0.02 children/million/year below the age of 14 years. We reported a 9-year-old girl presented to emergency department with pallor and haemoglobin of 50 g/L. Read More

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Coats plus syndrome: a rare cause of severe gastrointestinal tract bleeding in children - a case report.

BMC Pediatr 2022 03 8;22(1):119. Epub 2022 Mar 8.

Department of Pediatric Radiology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Background: Coats plus syndrome, cerebroretinal microangiopathy with calcifications and cysts, is a rare disease with autosomal recessive pattern occurring due to a mutation in CTC1, encoding conserved telomere maintenance component 1, gene. Besides retinal involvement, abnormalities in brain and osteopenia, serious life-threatening bleeding in gastrointestinal tract and portal hypertension can be observed.

Case Presentation: A 6-year-old girl with Coats plus syndrome presented to the pediatric emergency department with vomiting blood and blood in stool. Read More

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Potential Utility of Fecal Calprotectin in Discriminating Colorectal Polyps From Other Major Etiologies in Children Presenting With Isolated Hematochezia.

J Korean Med Sci 2022 Mar 7;37(9):e72. Epub 2022 Mar 7.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: Colorectal polyps are the most common cause of isolated hematochezia in children, which requires a colonoscopy for diagnosis. We aimed to investigate the potential utility of fecal calprotectin (FC) in assessing colorectal polyps detected by colonoscopy among children presenting with isolated hematochezia.

Methods: Pediatric patients of the age of < 18 years who had undergone both colonoscopy and FC tests for isolated hematochezia from June 2016 to May 2020 were included in the present multicenter, retrospective, cross-sectional study. Read More

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Surgical repair of massive hemorrhage secondary to button battery ingestion causing aortoesophageal fistula.

J Card Surg 2022 Mar 3. Epub 2022 Mar 3.

Division of Cardiac Surgery, University of Alberta, Edmonton, Alberta, Canada.

Background: In pediatrics, foreign body ingestion poses unique challenges. Each case is unique given variability in timing, type, and size of object, compounded by underlying comorbidities and age. In the mid-1990s, mortality and morbidity associated with button battery (BB) ingestion (BBI) emerged corresponding to modification in battery fabrication towards higher voltage, large-diameter lithium cells. Read More

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Clinical effect of combination of octreotide and omeprazole in children with acute upper gastrointestinal bleeding and the levels of serum creatinine and serum urea nitrogen.

Pak J Pharm Sci 2022 Jan;35(1(Special)):343-347

The People's Hospital of Dadukou District, Chongqing, China.

Pediatric upper gastrointestinal bleeding refers to an acute massive hemorrhage of the upper digestive tract and biliary tract, which is a common clinical emergency in pediatrics. This study aimed to evaluate the clinical effect of octreotide combined with omeprazole in pediatric upper gastrointestinal bleeding. Totally 84 cases of pediatric upper gastrointestinal bleeding admitted to Ningbo Women and Children's Hospital from November 2019 to April 2021 were divided into groups according to the admission order. Read More

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January 2022

Stress Ulcer Prophylaxis for Critical Asthma.

Pediatrics 2022 04;149(4)

Pediatric Critical Care Medicine.

Background: Children hospitalized for critical asthma (CA) in the pediatric ICU (PICU) are commonly prescribed stress ulcer prophylaxis (SUP) to mitigate risk of gastrointestinal (GI) bleeding. We sought to describe trends for SUP prescribing and explore for differences in rates of GI bleeding, gastritis, and SUP-related complications for those with and without SUP exposure.

Methods: We performed a retrospective, multicenter cohort study using the Pediatric Hospital Information System registry among 42 children's hospitals from 2010 to 2019 including children 3 to 17 years of age admitted to the PICU for CA. Read More

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LioNeo project: a randomised double-blind clinical trial for nutrition of very-low-birth-weight infants.

Br J Nutr 2022 Feb 11:1-8. Epub 2022 Feb 11.

Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

We assessed the effectiveness of lyophilised banked human milk (HM) as a fortifier to feed very-low-birth-weight infants (VLBWI). This study aimed to evaluate the safety and tolerability of HM with HM lyophilisate as an additive compared with the standard additive (cows' milk protein). In this phase I double-blind randomised controlled clinical trial, set in the intensive and intermediate care units of a tertiary hospital, forty VLBWI were enrolled and allocated into two groups: HM plus HM lyophilisate (LioNeo) or HM plus commercial additive (HMCA). Read More

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February 2022

Flow assessment as a function of pump timing of tubular pulsatile pump for use as a ventricular assist device in a left heart simulator.

Artif Organs 2022 Feb 7. Epub 2022 Feb 7.

Department of Pediatrics, Division of Hematology and Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.

Introduction: Although mechanical circulatory support saved many lives during the last decade, clinical observations have shown that the continuous flow pumps are associated with a much higher incidence of gastrointestinal bleeding and kidney problems, among others, compared with the earlier generation pulsatile pumps. However, the presence of several moving mechanical components made pulsatile pumps less durable, bulky, and prone to malfunction, ultimately leading to bias in favor of continuous flow designs.

Objective: The aim of the current work is to create a prototype tubular pulsatile pump and to test the timing of the pump in a left heart simulator. Read More

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February 2022

Stenting of ductus venosus as a palliation for portal hypertension because of neonatal cirrhosis.

Liver Int 2022 04 15;42(4):879-883. Epub 2022 Feb 15.

Division of Pediatric Cardiology, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA.

Portal hypertension because of liver cirrhosis is a significant cause of morbidity and mortality. Treatment options in these patients include liver transplant, symptomatic treatment of oesophageal varices via endoscopic treatment and symptomatic management of ascites. Portosystemic shunt creation can be challenging in newborns and infants. Read More

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Eighteen-year-old man with syncope with as the culprit: a case report.

AME Case Rep 2022 25;6. Epub 2022 Jan 25.

Department of Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

is amongst the most common chronic bacterial infection in humans. Pediatric patients appear to differ from their adult counterparts in terms of the prevalence, the complication rate, and the rate of antibiotic resistance. In this report, we present an 18-year-old man without any past medical history who was evaluated after an episode of syncope. Read More

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January 2022

Efficacy and Safety of Oral Acetaminophen for Premature Infants With Patent Ductus Arteriosus: A Meta-Analysis.

Front Pharmacol 2021 18;12:696417. Epub 2022 Jan 18.

Department of Pediatrics, Division of Neonatology, The Third Xiangya Hospital, Central South University, Changsha, China.

: To systematically review the efficacy and safety of oral Acetaminophen for premature infants with patent ductus arteriosus (PDA). : Databases including Ovid, EMbase, Pubmed, The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINHAL), China National Knowledge Infrastructure (CNKI), Chinese Biomedical Database (CBM), WanFang Data, China Science and Technology Journal Database were searched to collect the randomized controlled trials (RCTs) about Acetaminophen for premature infants with PDA from inception to January 1, 2021. Quality assessment was performed through bias risk evaluation according to the Cochrane Handbook 5. Read More

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January 2022