1,194 results match your criteria Pediatrics Gastrointestinal Bleeding


Inflammatory Bowel Disease in Children: Experience and Constraints in a Resource-limited Setting.

Cureus 2020 Apr 27;12(4):e7848. Epub 2020 Apr 27.

Pediatrics/Pediatric Gastroenterology, Hepatology and Nutrition Division, University of Calabar/University of Calabar Teaching Hospital, Calabar, NGA.

Introduction: Inflammatory bowel disease (IBD), though well described in the Caucasian population, is rarely encountered in the black African children. The aim of this study was to increase the awareness of this emerging condition in African children and highlight the constraints of management in a resource-limited setting like Nigeria.

Methods: This study included an audit of children with IBD who were seen between January 2015 and February 2020 at the Lagos University Teaching Hospital (LUTH). Read More

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http://dx.doi.org/10.7759/cureus.7848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253077PMC

Gastrointestinal involvement in childhood vasculitides.

Acta Paediatr 2020 Jun 1. Epub 2020 Jun 1.

Meyer Children's University Hospital and Department, NEUROFARBA, University of Florence, Viale Pieraccini 24, Florence, 50137, Italy.

Aim: The aim of this narrative review was to provide a comprehensive summary of the characteristics of gastrointestinal (GI) involvement in the most common paediatric primary vasculitides.

Methods: We used PubMed to primarily identify papers, reviews, case series and editorials published in English from 2000 until 31 January 2020. Based on this, we report the prevalence, clinical manifestations, diagnostic approaches and management of GI involvement in each vasculitis. Read More

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http://dx.doi.org/10.1111/apa.15381DOI Listing

Plasma perfusion combined with plasma exchange in chronic hepatitis B-related acute-on-chronic liver failure patients.

Hepatol Int 2020 May 29. Epub 2020 May 29.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, 430030, Hubei Province, China.

Background And Aims: Artificial liver support systems (ALSS) have been shown to significantly reduce mortality in patients with acute-on-chronic liver failure (ACLF). However, the characteristics of patients who would benefit most from ALSS treatment are poorly understood. This study aimed to delineate the indicators for ALSS and evaluate the effectiveness of plasma perfusion combined with plasma exchange (PP + PE) in patients with hepatitis B virus-related ACLF (HBV-ACLF). Read More

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http://dx.doi.org/10.1007/s12072-020-10053-xDOI Listing
May 2020
2.468 Impact Factor

DIFFUSED VASCULAR MALFORMATION OF THE ENTIRE COLON: UNUSUAL ETIOLOGY OF GASTROINTESTINAL BLEEDING IN PEDIATRICS.

Gastroenterol Nurs 2020 May/Jun;43(3):264-266

Chunyan Li, PhD, The First Hospital of Jilin University, Changchun, China. Shengbo Fang, MD, The First Hospital of Jilin University, Changchun, China. Nan Wang, MD, The First Hospital of Jilin University, Changchun, China. Lingli Qi, MD, The First Hospital of Jilin University, Changchun, China. Yufei Liu, PhD, The First Hospital of Jilin University, Changchun, China.

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http://dx.doi.org/10.1097/SGA.0000000000000514DOI Listing

Thinking Beyond HLH: Clinical Features of Patients with Concurrent Presentation of Hemophagocytic Lymphohistiocytosis and Thrombotic Microangiopathy.

J Clin Immunol 2020 May 23. Epub 2020 May 23.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune system activation driven mainly by high levels of interferon gamma. The clinical presentation of HLH can have considerable overlap with other inflammatory conditions. We present a cohort of patients with therapy refractory HLH referred to our center who were found to have a simultaneous presentation of complement-mediated thrombotic microangiopathy (TMA). Read More

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http://dx.doi.org/10.1007/s10875-020-00789-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245179PMC

Laparoscopic diverticulectomy or laparoscopic-assisted resection of symptomatic Meckel diverticulum in children? A systematic review.

Pediatr Surg Int 2020 May 20. Epub 2020 May 20.

Department of Paediatric Surgery, Level 3 CSB, Wellington Children's Hospital, Riddiford St, Newtown, Wellington, 6021, New Zealand.

Recent reports have recommended laparoscopic diverticulectomy for symptomatic Meckel diverticulum (MD) rather than laparoscopic-assisted extracorporeal resection. This technique may risk leaving residual ectopic mucosa leading to complications. This systematic review attempts to quantify the relative risks of both approaches. Read More

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http://dx.doi.org/10.1007/s00383-020-04673-5DOI Listing

Faecal calprotectin and ultrasonography as non-invasive screening tools for detecting colorectal polyps in children with sporadic rectal bleeding: a prospective study.

Ital J Pediatr 2020 May 20;46(1):66. Epub 2020 May 20.

Gastroenterology and Gastrointestinal Endoscopy Unit, Sapienza University of Rome, Sant'Andrea University Hospital, Rome, Italy.

Background: Colorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed for lower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bowel preparation and general anaesthesia or deep sedation, and in rare cases, it can cause complications. Non-invasive screening techniques able to predict polyps in children with isolated and sporadic rectal bleeding may play a key role in the selection of patients needing colonoscopy. Read More

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http://dx.doi.org/10.1186/s13052-020-00828-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238517PMC

McCune Albright Syndrome: Gastrointestinal Polyps and Platelet Dysfunction over 12 Years.

Horm Res Paediatr 2020 May 8:1-6. Epub 2020 May 8.

Department of Endocrinology, The Royal Children's Hospital, Parkville, Victoria, Australia.

Background And Objective: Gastrointestinal (GI) polyps with unknown malignant potential and a platelet storage pool deficiency that increases the risk of severe intraoperative and other types of bleeding have been identified in McCune-Albright syndrome (MAS). The natural course of these disorders has not been well characterized. The aim of this study was to report the follow-up of GI polyps and platelet dysfunction (PD) in a cohort of 28 patients with MAS. Read More

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http://dx.doi.org/10.1159/000507442DOI Listing

Henoch-Schönlein Purpura in Children: An Updated Review.

Curr Pediatr Rev 2020 May 7. Epub 2020 May 7.

Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur. Malaysia.

Background: Henoch-Schönlein purpura (HSP) is an IgA-mediated systemic small-vessel vasculitis with a predilection for the skin, gastrointestinal tract, joints, and kidneys. It is the most common form of systemic vasculitis in children.

Objective: To familiarize physicians with the etiopathogenesis, etiology, clinical manifestations, evaluation, and management of children with Henoch-Schönlein purpura. Read More

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http://dx.doi.org/10.2174/1573396316666200508104708DOI Listing

Complications and mortality of venovenous extracorporeal membrane oxygenation in the treatment of neonatal respiratory failure: a systematic review and meta-analysis.

BMC Pulm Med 2020 May 7;20(1):124. Epub 2020 May 7.

Department of Neonatology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.

Background: Extracorporeal membrane oxygenation (ECMO) has been increasingly used for severe neonatal respiratory failure refractory to conventional treatments. To systematically evaluate the complications and mortality of venovenous ECMO (VV ECMO) in the treatment of neonatal respiratory failure, we performed a systematic review and meta-analysis of all the related studies.

Methods: PubMed, Embase, and Cochrane Library were searched. Read More

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http://dx.doi.org/10.1186/s12890-020-1144-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204219PMC

Meckel Diverticulum Presenting as Abdominal Pain and Subsequent Bowel Perforation.

J Emerg Med 2020 Apr 18. Epub 2020 Apr 18.

Department of Pediatrics, University of California, San Francisco, San Francisco, California; Department of Emergency Medicine, University of California, San Francisco, San Francisco, California.

Background: Abdominal pain is a common presenting symptom with a broad array of potential etiologies. Meckel diverticulum (MD), the most common congenital gastrointestinal malformation, classically presents with painless gastrointestinal bleeding. However, it can also lead to diverticulitis, intussusception, or obstruction, manifesting as abdominal pain. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.03.019DOI Listing

Pulmonary Involvement in Acute Rheumatic Fever: A Case Report and Literature Review.

Cureus 2020 Mar 16;12(3):e7295. Epub 2020 Mar 16.

Department of Pediatric Rheumatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.

Rheumatic pneumonia is a pulmonary complication of rheumatic fever, often with grave outcomes. It has been described sporadically in literature, most recently a decade ago. Here, we describe a case of a 12-year-old Native American girl presenting with chest pain, gastrointestinal complaints, and frequent nosebleeds. Read More

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http://dx.doi.org/10.7759/cureus.7295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163343PMC

Dieulafoy lesion: two pediatric case reports.

Ital J Pediatr 2020 Apr 19;46(1):48. Epub 2020 Apr 19.

Gastrointestinal Endoscopy Unit, Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Background: Massive gastrointestinal bleeding in children is uncommon. Dieulafoy lesion is an uncommon disease which may lead to massive and repeated upper gastrointestinal hemorrhage. We report two cases of gastric Dieulafoy lesion successfully treated with either band ligation or endoscopic hemoclipping. Read More

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http://dx.doi.org/10.1186/s13052-020-0814-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168840PMC
April 2020
1.236 Impact Factor

Outcomes of Children With Cystic Fibrosis Admitted to PICUs.

Pediatr Crit Care Med 2020 Apr 17. Epub 2020 Apr 17.

Division of Critical Care Medicine, Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA.

Objectives: Data on outcomes of children with cystic fibrosis admitted to PICUs are limited and outdated. Prior studies cite PICU mortality rates ranging from 37.5% to 100%. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002358DOI Listing

Hemorrhagic colitis can be a life-threatening side effect of oseltamivir.

Pediatr Int 2020 May 17;62(5):634-635. Epub 2020 Apr 17.

Department of Pediatrics, Niigata City General Hospital, Niigata, Japan.

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http://dx.doi.org/10.1111/ped.14138DOI Listing

Post-traumatic Pseudoaneurysm of Hepatic Artery: An Unusual Cause of Upper Gastrointestinal Bleeding.

Indian Pediatr 2020 Apr;57(4):370-372

Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Bihar, India.

Pseudoaneurysm of hepatic artery with upper gastrointestinal bleeding is a rare but life-threatening complication of blunt trauma to the abdomen. An 8-year-old child with this condition was treated successfully with percutaneous coil embolization of the pseudoanysm. Read More

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April 2020
1.014 Impact Factor

Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.

Science 2020 04;368(6487):186-189

Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, Cornell University, New York, NY, USA.

Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but the importance and regulation of these changes remain unclear. We found that hepcidin, the master regulator of systemic iron homeostasis, is required for tissue repair in the mouse intestine after experimental damage. This effect was independent of hepatocyte-derived hepcidin or systemic iron levels. Read More

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http://dx.doi.org/10.1126/science.aau6481DOI Listing
April 2020
31.477 Impact Factor

Arteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report.

Surg Case Rep 2020 Apr 8;6(1):67. Epub 2020 Apr 8.

Department of Pediatric Surgery, Kanazawa Medical University, Ishikawa, Japan.

Background: Various terms have been used to describe vascular lesions in the intestine, including angiodysplasia, arteriovenous malformation, and telangiectasia. Such lesions are common in adults and are typified by angiodysplasia, a type of arteriovenous malformation. In contrast, these lesions are rarely seen in the pediatric population. Read More

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http://dx.doi.org/10.1186/s40792-020-00824-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142189PMC

The rule of two's didn't work: a case of Meckel's diverticulum with hemorrhagic shock in an adolescent.

Am J Emerg Med 2020 Mar 24. Epub 2020 Mar 24.

Department of Emergency Medicine, UNC Hospitals, Chapel Hill, NC, United States of America.

Meckel's diverticulum classically follows the rule of two's; presenting before the age of two years, found 2 ft. from the ileocecal valve, approximately 2 in. in length, and present in roughly 2% of the population. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.03.034DOI Listing

Tag-less patency capsule for suspected small bowel stenosis: A nationwide multicenter prospective study in Japan.

Dig Endosc 2020 Mar 25. Epub 2020 Mar 25.

Department of Gastroenterology, Fukuoka University Chikushi Hospital.

Study Aims: The PillCam patency capsule (PPC) is an Agile tag-less patency capsule used to evaluate gastrointestinal (GI) patency. We determined the appropriate use of PPC to preclude subsequent small bowel capsule endoscopy (SBCE) retention.

Methods: This prospective multicenter study consecutively enrolled patients indicated for SBCE with suspected or established small bowel stenosis. Read More

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http://dx.doi.org/10.1111/den.13673DOI Listing

Ibrutinib for the treatment of chronic graft-vs-host disease in pediatric hematopoietic stem cell transplant patients: A single-center experience.

Pediatr Transplant 2020 May 23;24(3):e13692. Epub 2020 Mar 23.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

cGVHD is a significant cause of morbidity and mortality after transplant. Ibrutinib has been studied as treatment for cGVHD in the adult population. Pediatric dosing and safety of ibrutinib are unknown. Read More

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http://dx.doi.org/10.1111/petr.13692DOI Listing

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement.

Arch Argent Pediatr 2020 Apr;118(2):139-142

Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

Background: Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement.

Methods: Children with HSP and healthy individuals as controls were included. Read More

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http://dx.doi.org/10.5546/aap.2020.eng.139DOI Listing

Juvenile Polyposis Syndrome in a Young Girl from Northern Tanzania.

Case Rep Surg 2020 3;2020:1536090. Epub 2020 Mar 3.

Department of General Surgery, Kilimanjaro Christian Medical Center, PO Box, 3010 Moshi, Tanzania.

. Juvenile polyposis syndrome is a rare autosomal dominant disorder in children characterized by multiple polyps in the gastrointestinal tract. A variety of clinical features manifest, including prolapse of a polyp or entire rectum, gastrointestinal bleeding, anaemia, and intussusception. Read More

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http://dx.doi.org/10.1155/2020/1536090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073492PMC

A case of rectal ulcers during aspirin therapy in acute Kawasaki disease.

Pediatr Rheumatol Online J 2020 Mar 17;18(1):24. Epub 2020 Mar 17.

Department of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Kawasaki disease (KD) is an acute febrile multisystem vasculitis and has been recognized to be one of the most common causes of acquired heart disease in children. Although gastrointestinal symptoms including vomiting, diarrhea, and abdominal pain are not uncommon in KD patients, KD with lower gastrointestinal bleeding is quite rare. Here, we describe a 3-year-old boy with typical KD who had lower gastrointestinal bleeding caused by rectal ulcers on the third day of aspirin therapy. Read More

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http://dx.doi.org/10.1186/s12969-020-0414-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076976PMC

Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality.

N Engl J Med 2020 03;382(11):1018-1028

From the Division of Gastroenterology and Hepatology (T.G.S., R.T.C., A.T.C.) and the Clinical and Translational Epidemiology Unit (T.G.S., A.T.C.), Department of Medicine, Massachusetts General Hospital, Harvard Medical School (T.G.S., R.T.C., A.T.C.), Broad Institute (R.T.C., A.T.C.), and the Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health (A.T.C.) - all in Boston; the Department of Infectious Diseases, School of Medical Sciences, Faculty of Medicine and Health (A.-S.D.), and the Department of Pediatrics (J.F.L.), Örebro University Hospital, Örebro, and the Department of Infectious Diseases, Karolinska University Hospital (S.A.), the Department of Medicine Huddinge (S.A.), and the Department of Medical Epidemiology and Biostatistics (J.F.L.), Karolinska Institutet, Stockholm - all in Sweden; and the Department of Medicine, Columbia University College of Physicians and Surgeons, New York (J.F.L.).

Background: More information is needed about the long-term effects of low-dose aspirin (≤160 mg) on incident hepatocellular carcinoma, liver-related mortality, and gastrointestinal bleeding in persons with chronic hepatitis B or hepatitis C virus infection.

Methods: Using nationwide Swedish registries, we identified all adults who received a diagnosis of chronic hepatitis B or hepatitis C from 2005 through 2015 and who did not have a history of aspirin use (50,275 patients). Patients who were starting to take low-dose aspirin (14,205 patients) were identified by their first filled prescriptions for 90 or more consecutive doses of aspirin. Read More

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http://dx.doi.org/10.1056/NEJMoa1912035DOI Listing

Extracorporeal Membrane Oxygenation Support for Pediatric Burn Patients: Is It Worth the Risk?

Pediatr Crit Care Med 2020 May;21(5):469-476

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN.

Objectives: Examine the outcomes of pediatric burn patients requiring extracorporeal membrane oxygenation to determine whether extracorporeal membrane oxygenation should be considered in this special population.

Design: Retrospective cohort study.

Setting: All extracorporeal membrane oxygenation centers reporting to the Extracorporeal Life Support Organization. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002269DOI Listing

Clinical outcome in pediatric refractory gastrointestinal Henoch-Schönlein purpura treated with mycophenolate mofetil.

Eur J Pediatr 2020 Mar 6. Epub 2020 Mar 6.

Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, People's Republic of China.

The aim of the present study was to investigate the clinical outcome of mycophenolate mofetil in pediatric refractory gastrointestinal (GI) Henoch-Schönlein purpura (HSP). Most of the HSP patients with GI symptoms may benefit from early introduction of glucocorticoid; however, a number of patients still do not achieve remission following the administration of steroids. Therefore, the present study was to investigate the clinical features and the clinical outcome of mycophenolate mofetil in refractory GI HSP. Read More

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http://dx.doi.org/10.1007/s00431-020-03592-wDOI Listing

Bleeding oesophageal varices in a 9 -year old girl as a late complication of neonatal umbilical catheterization.

Niger J Clin Pract 2020 Mar;23(3):429-433

Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.

Bleeding oesophageal varices is a rare condition in children and most of them are usually of extrahepatic causes. Neonatal umbilical catheterization even though safe has been identified as a cause of portal vein thrombosis and oesophaeal varices. We report a 9-year old Nigerian girl who had massive upper gastrointestinal bleeding from oesophageal varices secondary to pulmonary vein stenosis. Read More

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http://dx.doi.org/10.4103/njcp.njcp_163_19DOI Listing

Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis.

Cochrane Database Syst Rev 2020 03 5;3:CD011573. Epub 2020 Mar 5.

Division of Pediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Gastroenterology and Nutrition Department, Diagonal Paraguay 362, 8th Floor, Santiago, Region Metropolitana, Chile, 8330074.

Background: Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including bleeding (haemorrhage) from oesophageal and gastrointestinal varices. Variceal bleeding commonly occurs in children with chronic liver disease or portal vein obstruction. Therefore, prevention is important. Read More

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http://dx.doi.org/10.1002/14651858.CD011573.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059883PMC

Predictive ability of neonatal illness severity scores for early death in extremely premature infants.

J Matern Fetal Neonatal Med 2020 Feb 25:1-6. Epub 2020 Feb 25.

Department of Pediatrics, School of Medicine, Iwate Medical University, Iwate, Japan.

The predictive ability of neonatal illness severity scores for mortality or morbidity in extremely premature infants has not been extensively studied. We aimed to evaluate the ability of neonatal illness severity scores [Clinical Risk Index for Babies II (CRIB II), Score for Neonatal Acute Physiology II (SNAP-II), and SNAP-Perinatal Extension II (SNAPPE-II)] in predicting mortality and short-term morbidity of extremely premature infants. This retrospective study involved 171 infants with gestational age (GA) between 22 and 27 weeks who were admitted to the NICU during 2010-2017. Read More

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http://dx.doi.org/10.1080/14767058.2020.1731794DOI Listing
February 2020

Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports.

Case Rep Hematol 2020 10;2020:5678210. Epub 2020 Feb 10.

Department of Hematology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Dasatinib, a second-line tyrosine kinase inhibitor (TKI), has been widely used in chronic myeloid leukemia (CML) and Philadelphia-positive B-cell acute lymphoblastic leukemia (Ph + B-ALL). Although dasatinib has been well tolerated, side effects including hemorrhage are not rare. Cases of bleeding disorders ultimately result in thrombocytopenia, but platelet aggregation dysfunction induced by dasatinib has also been demonstrated in Ph + B-ALL and CML patients. Read More

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http://dx.doi.org/10.1155/2020/5678210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035504PMC
February 2020

Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays.

Mutagenesis 2020 03;35(2):161-167

Litron Laboratories, Winton Place, Rochester, NY.

Inflammatory bowel disease (IBD) is an important risk factor for gastrointestinal cancers. Inflammation and other carcinogenesis-related effects at distal, tissue-specific sites require further study. In order to better understand if systemic genotoxicity is associated with IBD, we exposed mice to dextran sulfate sodium salt (DSS) and measured the incidence of micronucleated cells (MN) and Pig-a mutant phenotype cells in blood erythrocyte populations. Read More

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http://dx.doi.org/10.1093/mutage/geaa006DOI Listing

Interventional Radiological Treatment of Paediatric Liver Transplantation Complications.

Cardiovasc Intervent Radiol 2020 May 10;43(5):765-774. Epub 2020 Feb 10.

Transplant Surgery Department, Charles University, First Faculty of Medicine, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 14021, Prague 4, Czech Republic.

Purpose: To assess the efficacy of percutaneous techniques in managing paediatric liver transplantation complications.

Material And Methods: We carried out 105 paediatric cadaveric donor liver transplantations at our centre from 2001 to 2018. Percutaneous techniques were used to treat 25 cases involving transplantation complications in 23 patients. Read More

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http://dx.doi.org/10.1007/s00270-020-02430-8DOI Listing

Newly Diagnosed Klippel-Trenaunay Syndrome Presenting with Rectal Polyposis in a Male Pediatric Patient: A Case Report.

Pediatr Gastroenterol Hepatol Nutr 2020 Jan 8;23(1):115-120. Epub 2020 Jan 8.

Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, Korea.

Klippel-Trenaunay syndrome (KTS) is a rare disorder characterized by a triad of abnormal bone and soft tissue growth, the presence of a port-wine stain, and venous malformations. Gastrointestinal (GI) manifestations of KTS are relatively common and generally do not cause significant problems. However, persistence can lead to chronic GI blood loss or even massive bleeding in rare cases. Read More

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http://dx.doi.org/10.5223/pghn.2020.23.1.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966219PMC
January 2020

Gastrointestinal hemorrhage before anticoagulant therapy in Kawasaki disease: a case report.

BMC Pediatr 2020 Jan 27;20(1):32. Epub 2020 Jan 27.

Department of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.

Background: Kawasaki disease (KD) is an acute febrile multisystem vasculitis and has been recognized to be the most common cause of acquired heart disease in children. Owing to its propensity to involve vessels throughout the entire body, KD often mimics other disease processes. The diagnosis might be delayed if other prominent symptoms appear before the characteristic clinical features of KD. Read More

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http://dx.doi.org/10.1186/s12887-020-1916-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983962PMC
January 2020

Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.

Cochrane Database Syst Rev 2020 01 27;1:CD004213. Epub 2020 Jan 27.

Surya Hospital for Women and Children, Department of Pediatrics, Pune, India.

Background: Patent ductus arteriosus (PDA) complicates the clinical course of preterm infants and increases the risk of adverse outcomes. Indomethacin has been the standard treatment to close a PDA but is associated with renal, gastrointestinal, and cerebral side effects. Ibuprofen has less effect on blood flow velocity to important organs. Read More

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http://dx.doi.org/10.1002/14651858.CD004213.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984616PMC
January 2020

Inherited coagulation disorders in Turkish children: A retrospective, single-center cohort study.

Transfus Apher Sci 2020 Jan 9:102728. Epub 2020 Jan 9.

Pediatric Hematology Specialist, Ankara Dışkapı Child Health and Diseases Hematology Oncology Training And Research Hospital, Ankara, Turkey.

Objective: This study aims to investigate the distribution, clinical characteristics and outcome of inherited coagulation disorders (ICD) in Turkish children.

Subjects And Methods: Data from all children (age<18 years) with ICD examined in our center were retrospectively reviewed.

Results: There were 403 children with ICD (233 males and 170 females) with a median age of four years at diagnosis. Read More

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http://dx.doi.org/10.1016/j.transci.2020.102728DOI Listing
January 2020

Outcome of Chinese children with craniopharyngioma: a 20-year population-based study by the Hong Kong Pediatric Hematology/Oncology Study Group.

Childs Nerv Syst 2020 Mar 23;36(3):497-505. Epub 2020 Jan 23.

Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, University of Hong Kong, Room 117, 1/F, New Clinical Building, 102 Pokfulam Road, Pok Fu Lam, Hong Kong.

Purpose: Craniopharyngioma is a rare low-grade neoplasm in children. Tumor progression occurs frequently, and survivors are at risk of long-term disease and treatment-related morbidities. We reviewed the population-based experience of managing pediatric craniopharyngioma in Hong Kong. Read More

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http://dx.doi.org/10.1007/s00381-019-04480-xDOI Listing

Sclerotherapy versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis.

Cochrane Database Syst Rev 2020 01 10;1:CD011659. Epub 2020 Jan 10.

Division of Pediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Gastroenterology and Nutrition Department, Diagonal Paraguay 362, 8th Floor, Santiago, Region Metropolitana, Chile, 8330074.

Background: Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including bleeding (haemorrhage) from oesophageal and gastrointestinal varices. Variceal bleeding commonly occurs in children with chronic liver disease or portal vein obstruction. Prevention is therefore important. Read More

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http://dx.doi.org/10.1002/14651858.CD011659.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956467PMC
January 2020

Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2.

Turk J Pediatr 2019 ;61(3):413-417

Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, USA.

Çakan M, Aktay-Ayaz N, Karadağ ŞG, Tahir-Turanlı E, Stafstrom K, Bainter W, Geha RS, Chou J. Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2. Turk J Pediatr 2019; 61: 413-417. Read More

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http://dx.doi.org/10.24953/turkjped.2019.03.014DOI Listing
January 2019

Complex profile of multiple hepatobiliary and gastrointestinal complications after hematopoietic stem cell transplantation in a child with Nijmegen breakage syndrome.

Cent Eur J Immunol 2019 30;44(3):327-331. Epub 2019 Sep 30.

Department of Paediatrics, Haematology and Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Antoni Jurasz University Hospital No. 1, Bydgoszcz, Poland.

Patients with Nijmegen breakage syndrome (NBS) can develop life-threatening immunodeficiency, which should be treated with hematopoietic stem cell transplantation (HSCT). We report the case of a 14-year-old girl with NBS who due to an increasing number of severe complications was referred for HSCT from a matched unrelated donor. After reduced-intensity conditioning and transplantation of peripheral blood hematopoietic cells, during the early post-transplant period (days 0-30), the girl suffered from severe mucositis, fever episodes, mild acute renal injury and facial vasculitis. Read More

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http://dx.doi.org/10.5114/ceji.2019.89612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925563PMC
September 2019

Direct Health Care Costs, Health Services Utilization, and Outcomes of Biliary Atresia: A Population-based Cohort Study.

J Pediatr Gastroenterol Nutr 2020 Apr;70(4):436-443

Children's Hospital of Eastern Ontario (CHEO) Research Institute, University of Ottawa.

Objectives: Biliary atresia (BA) is the most common reason for liver transplant in childhood, and outcomes worsen with older age at hepatoportoenterostomy (HPE). We determined direct health care costs in children with BA, compared to controls in a population-based cohort of children in Ontario, Canada.

Methods: We used health administrative data to identify all children diagnosed with BA between 2002 and 2016 (n = 121) and matched controls (n = 602). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002582DOI Listing

Stress Ulcer Prophylaxis in Critically Ill Children: A Multicenter Observational Study.

Pediatr Crit Care Med 2020 02;21(2):e107-e113

St. Joseph's Healthcare, Hamilton, ON, Canada.

Objective: To describe current stress ulcer prophylaxis practice in Canadian PICUs.

Design: Multicenter cohort study. We defined stress ulcer prophylaxis as the use of a proton-pump inhibitor, histamine-2 receptor antagonist, or sucralfate within the first 2 PICU days among children who had not been on these medications at home and had no evidence of gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002202DOI Listing
February 2020

Juvenile Polyp associated with Hypovolemic Shock Due to Massive Lower Gastrointestinal Bleeding.

Pediatr Gastroenterol Hepatol Nutr 2019 Nov 7;22(6):613-618. Epub 2019 Nov 7.

Department of Pediatrics, Konyang University College of Medicine, Daejeon, Korea.

Juvenile polyps are the most common types of polyps in children, and patients usually present with lower gastrointestinal (GI) bleeding as the predominant symptom. These lesions, which are referred to as hamartomas, usually measure approximately 2 cm in size and are benign tumors located mainly in the rectum and sigmoid colon. The most common symptom of a juvenile polyp is mild intermittent rectal bleeding. Read More

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http://dx.doi.org/10.5223/pghn.2019.22.6.613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856507PMC
November 2019

Acute gastrointestinal hemorrhage in Kawasaki disease occurring before aspirin therapy.

Pediatr Int 2019 Nov;61(11):1177-1178

Department of Gastroenterology, Kyoto Chubu Medical Center, Kyoto, Japan.

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http://dx.doi.org/10.1111/ped.13989DOI Listing
November 2019

Use of alarm features in predicting significant endoscopic findings in Nigerian patients with dyspepsia.

Pan Afr Med J 2019 2;34:66. Epub 2019 Oct 2.

Arrive Alive Diagnostic and Imaging Services, Surulere, Lagos, Nigeria.

Introduction: Dyspepsia is prevalent in the community. Guidelines recommend early endoscopy in dyspeptic patients who are older than 55 years, or have alarm features. There is a lack of data on endoscopy in patients with alarm features in Nigeria. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.66.18848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859056PMC
December 2019

Intravenous Bevacizumab Reduces Transfusion Requirements and Endoscopic Interventions in Patients With Gastric Antral Vascular Ectasia and Small Bowel Angioectasia.

Gastroenterology 2020 03 21;158(4):1162-1163.e4. Epub 2019 Nov 21.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.11.027DOI Listing

Effect of Aspiration and Evaluation of Gastric Residuals on Intestinal Inflammation, Bleeding, and Gastrointestinal Peptide Level.

J Pediatr 2020 Feb 19;217:165-171.e2. Epub 2019 Nov 19.

Department of Pediatrics, University of Florida, Gainesville, FL.

Objective: To determine the effect of gastric residual aspiration and evaluation on preterm very low birth weight infants' gastrointestinal function, intestinal inflammation, and gastrointestinal mucosal bleeding.

Study Design: This single-center, randomized trial compared omission of gastric residuals vs prefeed gastric residuals in 143 infants ≤32 weeks of gestation with a birthweight of ≤1250 g for 6 weeks after birth. Serum levels of gastrin and motilin were collected between 14 and 21 days of life. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012706PMC
February 2020

The influence on renal function of ibuprofen treatment for patent ductus arteriosus in extremely low birthweight infants.

Pediatr Int 2020 Feb 3;62(2):193-199. Epub 2020 Feb 3.

Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: Ibuprofen (IBU) has been used recently for the treatment of patent ductus arteriosus (PDA) in Japan. We aimed to investigate the efficacy and adverse events of IBU and compare them with those of indomethacin (IND) as PDA treatment for extremely low-birthweight infants (ELBWIs), focusing on short-term renal function.

Methods: A case-control study was conducted on 16 ELBWIs. Read More

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http://dx.doi.org/10.1111/ped.14057DOI Listing
February 2020