1,071 results match your criteria Pediatrics Gastrointestinal Bleeding


A phase III study comparing secondary long-term prophylaxis versus on-demand treatment with vWF/FVIII concentrates in severe inherited von Willebrand disease.

Blood Transfus 2019 Feb 4:1-8. Epub 2019 Feb 4.

Division of Haematology and Transfusion Medicine, "Luigi Sacco" University Hospital, Milan, Italy.

Background: There is a lack of prospective clinical trials specifically designed to evaluate the benefits of prophylaxis with vWF/FVIII concentrates in patients with inherited von Willebrand disease (vWD). The aim of the study was to compare efficacy of secondary long-term prophylaxis (PRO) with vWF/FVIII in the prevention of bleeding episodes in severe vWD patients to standard of care (on-demand treatment; ODT).

Materials And Methods: In this 12-month, phase III, open-label study (PRO. Read More

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http://dx.doi.org/10.2450/2019.0183-18DOI Listing
February 2019

Bleeding and safety outcomes in persons with haemophilia A without inhibitors: Results from a prospective non-interventional study in a real-world setting.

Haemophilia 2019 Feb 6. Epub 2019 Feb 6.

Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and NHLS, Parktown, Johannesburg, South Africa.

Introduction: Prospectively collected real-world data on bleeds, haemophilia treatment and safety in persons with haemophilia A (PwHA) without factor VIII (FVIII) inhibitors are limited. A global, non-interventional study (NIS; NCT02476942) prospectively collected real-world data in PwHA who were treated per local routine clinical practice.

Aim: Assess annualized bleeding rate (ABR), haemophilia treatment practices and adverse events (AEs) in adult/adolescent PwHA without inhibitors. Read More

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http://dx.doi.org/10.1111/hae.13655DOI Listing
February 2019
1 Read

Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.

Front Pediatr 2018 21;6:426. Epub 2019 Jan 21.

Immunodeficiencies Research Unit at the National Institute of Pediatrics (INP), Mexico City, Mexico.

DNA repair defects are inborn errors of immunity that result in increased apoptosis and oncogenesis. DNA Ligase 4-deficient patients suffer from a wide range of clinical manifestations since early in life, including: microcephaly, dysmorphic facial features, growth failure, developmental delay, mental retardation; hip dysplasia, and other skeletal malformations; as well as a severe combined immunodeficiency, radiosensitivity, and progressive bone marrow failure; or, they may present later in life with hematological neoplasias that respond catastrophically to chemo- and radiotherapy; or, they could be asymptomatic. We describe the clinical, laboratory, and genetic features of five Mexican patients with LIG4 deficiency, together with a review of 36 other patients available in PubMed Medline. Read More

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http://dx.doi.org/10.3389/fped.2018.00426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348249PMC
January 2019
2 Reads

Significant Hematochezia and Intracranial Bleeding in Neonatal Hereditary Hemorrhagic Telangiectasia.

AJP Rep 2019 Jan 29;9(1):e10-e14. Epub 2019 Jan 29.

Department of Human Genetics, Emory University, Atlanta, Georgia.

Hereditary hemorrhagic telangiectasia (HHT) is an underreported autosomal dominant vascular dysplasia. Neonatal presentations of HHT are rare, as this disorder typically presents in adolescence or beyond with epistaxis. We report a female neonate with hematochezia on the 1st day of life secondary to multiple gastrointestinal arteriovenous malformations (AVMs) along with intracranial hemorrhage. Read More

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http://dx.doi.org/10.1055/s-0039-1677735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351274PMC
January 2019
1 Read

Meckel's Diverticulum Diagnosed in a Child with Suspected Small Bowel Crohn's Disease.

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):98-104. Epub 2019 Jan 10.

Department of Pediatrics, Jeju National University School of Medicine, Jeju, Korea.

We report a rare case of Meckel's diverticulum in a boy who initially presented with chronic iron deficiency anemia (IDA) without any history of gastrointestinal (GI) bleeding at 8 years-old. Isolated small bowel Crohn's disease was suspected based on findings of small bowel ulcers on capsule endoscopy. At four years from initial presentation, he developed massive GI bleeding. Read More

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http://dx.doi.org/10.5223/pghn.2019.22.1.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333590PMC
January 2019
1 Read

The Characteristics and Outcomes of Abernethy Syndrome in Korean Children: A Single Center Study.

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):80-85. Epub 2019 Jan 10.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Abernethy malformation is a rare condition, which was first described in 1793 as a congenital extrahepatic porto-systemic shunt (CEPS) directing splanchnic blood flow into the inferior vena cava. Eighty cases have been published so far that reported CEPS, while in Korea, very few cases have been reported. Through this study, we present 6 cases of patients diagnosed with CEPS at Samsung Medical Center and compare these with other such cases published in France and China. Read More

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http://dx.doi.org/10.5223/pghn.2019.22.1.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333588PMC
January 2019
1 Read

Usefulness of Ultrasonography in the Diagnosis of Peptic Ulcer Disease in Children.

Pediatr Gastroenterol Hepatol Nutr 2019 Jan 10;22(1):57-62. Epub 2019 Jan 10.

Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea.

Purpose: This study was performed to assess the clinical usefulness of transabdominal ultrasonography (TUS) in detecting peptic ulcer disease (PUD) in children.

Methods: Twenty-four patients (19 boys, 5 girls; mean age, 10.6±4. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5223/pghn.2019.2
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http://dx.doi.org/10.5223/pghn.2019.22.1.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333589PMC
January 2019
4 Reads

Various initial presentations of Epstein-Barr virus infection-associated post-transplant lymphoproliferative disorder in pediatric liver transplantation recipients: Case series and literature review.

Pediatr Transplant 2019 Jan 20:e13357. Epub 2019 Jan 20.

Faculty of Medicine Ramathibodi Hospital, Department of Pediatrics, Division of Gastroenterology, Mahidol University, Bangkok, Thailand.

PTLD is a rare but potentially life-threatening condition, which shows a higher prevalence in children than in adults. From 129 children who underwent LT, we reported 5 cases with biopsy-proven PTLD at a single teaching hospital. Four patients had shared clinical presentations including fever, lymphadenopathy, and splenomegaly. Read More

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http://doi.wiley.com/10.1111/petr.13357
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http://dx.doi.org/10.1111/petr.13357DOI Listing
January 2019
6 Reads

Ranitidine-Induced Delirium in a 7-Year-Old Girl: A Case Report.

Pediatrics 2019 Jan 11. Epub 2019 Jan 11.

Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Ranitidine is a histamine-2 blocker commonly prescribed in PICUs for the prophylaxis of gastrointestinal bleeding and stress ulcers. However, it can be associated to central nervous system side effects, such as delirium, in adults. We present the first case of a child presenting delirium possibly caused by anticholinergic toxidrome secondary to the use of ranitidine, resolving after drug discontinuation. Read More

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http://dx.doi.org/10.1542/peds.2018-2428DOI Listing
January 2019
1 Read

Infantile-onset inflammatory bowel disease in a patient with Hermansky-Pudlak syndrome: a case report.

BMC Gastroenterol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.

Background: Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten genetic subtypes of this autosomal recessive condition have been described to date. Some patients with Hermansky-Pudlak syndrome type 1, 4, or 6 develop Crohn's-like inflammatory bowel disease at any age including early childhood, but most often in adolescence or young adulthood. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0929-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329123PMC
January 2019
10 Reads

Management of Peutz-Jeghers syndromes in children and adolescents: A Position Paper from the ESPGHAN Polyposis Working Group.

J Pediatr Gastroenterol Nutr 2018 Dec 19. Epub 2018 Dec 19.

St Mark's Hospital Polyposis Registry UK.

Peutz-jeghers syndrome (PJS) is a well-described inherited syndrome, characterised by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. Development of small bowel intestinal polyps may lead to intussusception in children may require emergency laparotomy with potential loss of bowel. Gastrointestinal (GI) polyps may lead to bleeding and anaemia. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002248DOI Listing
December 2018
7 Reads

Small Bowel Mucosal Involvement and Mesenteric Mass Formation in a Young Female with Type 3 Gaucher Disease. A Case Report.

J Gastrointestin Liver Dis 2018 Dec;27(4):459-463

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC., USA.

Gaucher Disease arises due to a deficiency in the enzyme glucocerebrosidase and is the most common lysosomal storage disease. This enzyme deficiency leads to the accumulation of glucocerebroside within macrophages (Gaucher cells) and the resulting infiltration of these cells into organs can cause clinical symptoms. There are three types of Gaucher Disease that differ based on the clinical course and the presence or absence of neurological involvement, but classically, Gaucher cell infiltrates impact a patient's spleen, liver, bone marrow and cortex. Read More

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http://dx.doi.org/10.15403/jgld.2014.1121.274.bowDOI Listing
December 2018
3 Reads

Ibuprofen, a Potential Cause of Acute Hemorrhagic Gastritis in Children - A Case Report.

J Crit Care Med (Targu Mures) 2018 Oct 1;4(4):143-146. Epub 2018 Oct 1.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania.

Introduction: Upper gastrointestinal bleeding is an uncommon but possible life-threatening entity in children, frequently caused by erosive gastritis. Non-steroidal anti-inflammatory drugs are one of the most common class of drugs which can cause gastrointestinal complications, including hemorrhagic gastritis.

Case Report: The case of a 6-year-old male, admitted for hematemesis, abdominal pain and loss of appetite. Read More

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http://content.sciendo.com/view/journals/jccm/4/4/article-p1
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http://dx.doi.org/10.2478/jccm-2018-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296277PMC
October 2018
11 Reads

Catheter-directed therapy for acute pulmonary embolism in children.

Cardiol Young 2018 Dec 21:1-7. Epub 2018 Dec 21.

1Division of Cardiology,Children's Hospital of Michigan,Carman and Ann Adams Department of Pediatrics,Wayne State University School of Medicine,Detroit,MI,USA.

Background: Acute pulmonary embolism is a life-threatening condition and rarely occurs in children. In adults, catheter-directed therapy emerges as a potentially safer and effective therapeutic option. However, there is a paucity of data on the safety and efficacy of catheter-directed therapy for pulmonary embolism in children. Read More

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http://dx.doi.org/10.1017/S1047951118002135DOI Listing
December 2018
1 Read

A case report of endoscopic therapy for radiation-induced hemorrhagic gastritis in patient with recurrent hepatocellular carcinoma.

Medicine (Baltimore) 2018 Dec;97(51):e13535

Department of Digestive Disease, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University.

Rationale: Radiation-induced hemorrhagic gastritis is an infrequent cause of upper gastrointestinal bleeding and difficult to manage. The current standard treatment has not been well established.

Patient Concerns: We described a 32-year-old male patient with hemorrhagic gastritis induced by external radiotherapy for hepatocellular carcinoma recurrence. Read More

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http://dx.doi.org/10.1097/MD.0000000000013535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320029PMC
December 2018
2 Reads

Eating disorder or disordered eating: undiagnosed inflammatory bowel disease mimicking eating disorder.

Arch Dis Child 2018 Dec 19. Epub 2018 Dec 19.

Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children Glasgow, Glasgow, UK.

We describe the case of a patient with ongoing weight loss, low mood and previously undisclosed gastrointestinal (GI) symptoms initially diagnosed with an eating disorder and subsequently diagnosed with ulcerative colitis over a year following initial presentation. This patient exhibited disordered eating secondary to the worsening symptoms of undiagnosed inflammatory bowel disease (IBD) and had altered her eating habits to reduce the diarrhoea and rectal bleeding she was experiencing, contributing to significant weight loss.The implications of a delayed diagnosis of IBD or incorrect diagnosis of eating disorder are severe both physically and psychologically. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316324DOI Listing
December 2018
3 Reads

Small Bowel Hemangioma in a 2-Year-Old Female With Recurrent Anemia.

Ochsner J 2018 ;18(4):428-432

The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.

Background: Hemangiomas of the small bowel are rare tumors that present with melena, hematochezia, or signs of anemia. Because of the rarity of gastrointestinal hemangiomas, they are not commonly considered in the differential diagnosis for pediatric patients with anemia.

Case Report: We present a case of small bowel hemangioma in a 2-year-old female with recurrent episodes of severe anemia. Read More

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http://dx.doi.org/10.31486/toj.18.0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292466PMC
January 2018
1 Read

Platelet transfusion practices in immune thrombocytopenia related hospitalizations.

Transfusion 2019 Jan 5;59(1):169-176. Epub 2018 Dec 5.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Division of Hematology/Oncology, Emory University School of Medicine, Atlanta, Georgia.

Background: The role of platelet transfusions in management of Immune Thrombocytopenia (ITP) remains controversial. Current guidelines recommend that platelet transfusions in ITP be reserved for catastrophic hemorrhage or invasive surgical procedures. This study assesses the nationwide platelet transfusion practices in hospitalized children and adults with ITP. Read More

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http://doi.wiley.com/10.1111/trf.15069
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http://dx.doi.org/10.1111/trf.15069DOI Listing
January 2019
18 Reads

Increasing Pediatricians' Awareness of the Association between Anal Skin Tags and Earlier Diagnosis of Crohn's Disease.

Inflamm Intest Dis 2018 Nov 4;3(1):40-42. Epub 2018 Oct 4.

Department of Biostatistics, Lenox Hill Hospital, New York, New York, USA.

Objective: To seek the habits of pediatricians by which anorectal skin tags (AST) of Crohn's disease might be overlooked.

Methods: Questionnaires were sent to pediatricians affiliated with the Northwell Health System.

Results: Based on the responses, the majority of pediatricians did feel the abdomen of children presenting with abdominal pain or diarrhea but did not spread the buttocks to seek the presence of AST unless there was rectal pain, rectal bleeding, or, in some cases, loose stools. Read More

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http://dx.doi.org/10.1159/000492921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266026PMC
November 2018
6 Reads

Patients Prescribed Direct-acting Oral Anticoagulants Have Low Risk of Post-Polypectomy Complications.

Clin Gastroenterol Hepatol 2018 Nov 29. Epub 2018 Nov 29.

Division of Gastroenterology, San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA, United States.

Background & Aims: Use of direct-acting oral anticoagulants (DOACs) is increasing, but little is known about the associated risks in patients undergoing colonoscopy with polypectomy. We aimed to determine the risk of post-polypectomy complications in patients prescribed DOACs.

Methods: We performed a retrospective analysis using the Clinformatics Data Mart Database (a de-identified administrative database from a large national insurance provider) to identify adults who underwent colonoscopy with polypectomy or endoscopic mucosal resection (EMR) from January 1, 2011, through December 31, 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565183132
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http://dx.doi.org/10.1016/j.cgh.2018.11.051DOI Listing
November 2018
12 Reads

External validation of a clinical prediction rule for very low risk pediatric blunt abdominal trauma.

Am J Emerg Med 2018 Nov 23. Epub 2018 Nov 23.

Department of Pediatrics, Division of Pediatric Emergency Medicine, Vanderbilt University Medical Center, 2200 Children's Way Suite 1025, Nashville, TN 37232, USA. Electronic address:

Background: Computed tomography (CT) is frequently used to identify intra-abdominal injuries in children with blunt abdominal trauma (BAT). The Pediatric Emergency Care Applied Research Network (PECARN) proposed a prediction rule to identify children with BAT who are at very low risk for clinically-important intra-abdominal injuries (CIIAI) in whom CT can be avoided.

Objective: To determine the sensitivity of this prediction rule in identifying patients at very low risk for CIIAI in our pediatric trauma registry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757183094
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http://dx.doi.org/10.1016/j.ajem.2018.11.031DOI Listing
November 2018
8 Reads

Treating Infantile Spasms with High-Dose Oral Corticosteroids: A Retrospective Review of 87 Children.

Pediatr Neurol 2018 Oct 3;87:30-35. Epub 2018 Aug 3.

Departments of Neurology and Pediatrics, The Johns Hopkins Hospital, Baltimore, Baltimore, Maryland. Electronic address:

Background: Hormonal therapy is the treatment of choice in most patients with infantile spasms, but the optimal way to provide this therapy is unclear. Intramuscular adrenocorticotropic hormone (ACTH) has historically used first-line; however, there are significant logistical and financial issues. Our institution has used high-dose prednisolone as the first-line hormonal treatment of infantile spasms since 2006 and published our early experience with 15 infants in 2009. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.06.011DOI Listing
October 2018
5 Reads

The Application of a Shorter Loop in Kasai Portoenterostomy Reconstruction for Ohi Type III Biliary Atresia: A Prospective Randomized Controlled Trial.

J Surg Res 2018 Dec 25;232:492-496. Epub 2018 Jul 25.

Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China. Electronic address:

Background: A 30-40 cm Roux loop is widely accepted in Kasai portoenterostomy in infants with Ohi Type III biliary atresia (BA), regardless of patient's size, to avoid reflux cholangitis. However, the redundant length of the jejunal limb may lead to complications; hence, we compared the outcome of a shorter Roux loop with the standard loop length in Kasai portoenterostomy in infants with Ohi Type III BA.

Methods: There were 166 patients with Ohi Type III BA who underwent the Kasai procedure and were prospectively randomized into two groups: (1) the long Roux loop group (LRLG) contained 91 patients, where a standard 30-40 cm Roux loop was used regardless of the child's size and (2) the short Roux loop group (SRLG) included 75 patients in which the Roux loop length was based on the distance between hepatic hilum and umbilicus. Read More

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http://dx.doi.org/10.1016/j.jss.2018.07.002DOI Listing
December 2018
16 Reads

Clinical Safety and Utility of Pediatric Balloon Assisted Enteroscopy; A Multicenter Prospective Study in Japan.

J Pediatr Gastroenterol Nutr 2018 Nov 15. Epub 2018 Nov 15.

Department of Pediatrics, Shinshu University School of Medicine.

Objectives: The benefit of balloon-assisted enteroscopy (BAE) had been recently documented in pediatric patients, but previous reports are based on single institution experiences. We evaluated the feasibility of pediatric BAE in 8 tertiary referral hospitals throughout Japan.

Methods: This was a prospective, multi-institutional study. Read More

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http://Insights.ovid.com/crossref?an=00005176-900000000-9663
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http://dx.doi.org/10.1097/MPG.0000000000002181DOI Listing
November 2018
8 Reads
2.625 Impact Factor

Analysis of Patients with Ventricular Assist Devices Presenting to an Urban Emergency Department.

West J Emerg Med 2018 Nov 10;19(6):907-911. Epub 2018 Sep 10.

Harvard University, Massachusetts General Hospital, Department of Emergency Medicine, Boston, Massachusetts.

Introduction: Left ventricular assist device (LVAD) insertion is an increasingly common intervention for patients with advanced heart failure; however, published literature on the emergency department (ED) presentation of this population is limited. The objective of this study was to characterize ED presentations of patients with LVADs with a focus on device-specific complications to inform provider education and preparation initiatives.

Methods: This was a retrospective chart review of all patients with LVADs followed at an urban academic medical center presenting to the ED over a five-year period (July 1, 2009, to June 30, 2014). Read More

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http://escholarship.org/uc/item/0854m7q3
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http://dx.doi.org/10.5811/westjem.2018.8.38851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225934PMC
November 2018
12 Reads

Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus.

Case Rep Pediatr 2018 8;2018:7654278. Epub 2018 Oct 8.

Division of Pediatric Hematology/Oncology, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free. Read More

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http://dx.doi.org/10.1155/2018/7654278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196891PMC
October 2018
11 Reads

A Newborn with Gastric Hemangioma Treated Using Propranolol.

Pediatr Gastroenterol Hepatol Nutr 2018 Oct 10;21(4):341-346. Epub 2018 Oct 10.

Division of Neonatology, Department of Pediatrics, Turgut Ozal Medical Center, Inonu University School of Medicine, Malatya, Turkey.

Gastric hemangiomas are rare benign vascular tumors that can cause severe gastrointestinal system bleeding. We presented the case of a neonate with fresh bleeding and melena from the orogastric tube and detected gastric hemangioma in esophagogastroduodenoscopic examination. Propranolol is widely used in treatment of cutaneous hemangiomas and non-gastric gastrointestinal system hemangiomas. Read More

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http://dx.doi.org/10.5223/pghn.2018.21.4.341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182481PMC
October 2018
2 Reads

Long-term Complications and Management of Gastrointestinal Bleeding in Multifocal Lymphangioendotheliomatosis.

J Pediatr Hematol Oncol 2018 Oct 16. Epub 2018 Oct 16.

Departments of Pediatrics, Division of Pediatric, Gastroenterology, Hepatology, and Nutrition.

Multifocal lymphangioendotheliomatosis with thrombocytopenia is a rare disease characterized by multiple cutaneous and gastrointestinal (GI) vascular lesions and thrombocytopenia refractory to platelet and blood cell transfusions. GI bleeding can become life-threatening in this condition. We report a case of multifocal lymphangioendotheliomatosis with thrombocytopenia in a male infant with isolated GI involvement, diagnosed when he was 3 months old. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001324DOI Listing
October 2018
2 Reads

Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis.

Front Immunol 2018 27;9:2211. Epub 2018 Sep 27.

Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital Research Institute (BCCHRI), University of British Columbia, Vancouver, BC, Canada.

Current ulcerative colitis (UC) treatments are focused on symptom management primarily via immune suppression. Despite the current arsenal of immunosuppressant treatments, the majority of patients with UC still experience disease progression. Importantly, aggressive long-term inhibition of immune function comes with consequent risk, such as serious infections and malignancy. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02211
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http://dx.doi.org/10.3389/fimmu.2018.02211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170651PMC
September 2018
6 Reads

Successful azathioprine treatment in an adolescent with chronic enteropathy associated with SLCO2A1 gene: A case report.

Medicine (Baltimore) 2018 Oct;97(41):e12811

Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan.

Introduction: Chronic nonspecific multiple ulcers of the small intestine (CNSU), an entity with female preponderance and manifestations including anemia and hypoproteinemia reflecting persistent gastrointestinal bleeding and intestinal protein loss, has been considered idiopathic. Umeno et al recently reported that CNSU is caused by loss-of-function mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) encoding a prostaglandin transporter, renaming the disorder "chronic enteropathy associated with SLCO2A1 gene mutation" (CEAS). Treatments for chronic enteropathies such as inflammatory bowel disease, including 5-aminosalicylic acid, corticosteroids, azathioprine, and anti-tumor necrosis factor-α antibody, often are ineffective in CEAS, which frequently requires surgery. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0009
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http://dx.doi.org/10.1097/MD.0000000000012811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203590PMC
October 2018
3 Reads

Incidence of immune thrombocytopenia in Taiwan: a nationwide population-based study.

Transfusion 2018 Nov 12;58(11):2712-2719. Epub 2018 Oct 12.

Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: The incidence of immune thrombocytopenia (ITP) is not well known in Asians. The aims of this study were to survey incidences and clinical features of ITP in Taiwan.

Study Design And Methods: This study identified 4855 incident ITP cases from the population-based National Health Insurance Research Database from mid-2006 to mid-2013, and compared incidences, patient characteristics, and clinical manifestations of ITP by age. Read More

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http://doi.wiley.com/10.1111/trf.14915
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http://dx.doi.org/10.1111/trf.14915DOI Listing
November 2018
11 Reads

Increased age and proton pump inhibitors are associated with severe Clostridium difficile infections in children.

J Microbiol Immunol Infect 2018 Sep 20. Epub 2018 Sep 20.

Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background: Clostridium difficile infection (CDI) is increasing in children. We aimed to compare the clinical characteristics between CDI and colonization and to identify the risk factors for severe diseases of CDI in children.

Method: We retrospectively reviewed 124 children (1-18 years old) from 2011 to 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16841182183018
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http://dx.doi.org/10.1016/j.jmii.2018.09.002DOI Listing
September 2018
5 Reads

Faecal Occult Blood Point-of-Care Tests.

J Gastrointest Cancer 2018 Dec;49(4):402-405

Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka St 265, 30-663, Cracow, Poland.

Background: Early detection of colorectal cancer decreases the risk of mortality. Faecal occult blood tests (FOBT) are recognised as a useful tool for colorectal cancer screening. These non-invasive, rapid, and easy-to-carry assays are very often used as a point-of-care test and for self-testing. Read More

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http://link.springer.com/10.1007/s12029-018-0169-1
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http://dx.doi.org/10.1007/s12029-018-0169-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208834PMC
December 2018
4 Reads

Enteroscopy in children.

United European Gastroenterol J 2018 Aug 12;6(7):961-969. Epub 2018 Jul 12.

Department of Medical and Surgical Sciences, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.

Introduction: Device-assisted enteroscopy is a new endoscopic technique for the evaluation of small bowel in adults and children. Data in pediatric population are limited. This review aims to identify diagnostic and therapeutic benefits of enteroscopy in children. Read More

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http://dx.doi.org/10.1177/2050640618789853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137589PMC
August 2018
5 Reads

Non-exposed endoscopic wall-inversion surgery for pediatric gastrointestinal stromal tumor: A case report.

Asian J Endosc Surg 2018 Aug 30. Epub 2018 Aug 30.

Departments of Surgery, Jichi Medical University, Shimotsuke, Japan.

Gastrointestinal stromal tumors (GIST) in patients under 18 years of age are classified as pediatric GIST. Pediatric GIST are extremely rare, and there are no reports of laparoscopic-endoscopic cooperative surgery for these lesions. We report the use of non-exposed endoscopic wall-inversion surgery as a laparoscopic-endoscopic cooperative surgery-related procedure for the treatment of a pediatric GIST. Read More

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http://dx.doi.org/10.1111/ases.12641DOI Listing
August 2018
2 Reads

Understanding the evolving phenotype of vascular complications in telomere biology disorders.

Angiogenesis 2019 Feb 25;22(1):95-102. Epub 2018 Aug 25.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, 6E456, Bethesda, MD, 20892-6772, USA.

Vascular complications such as bleeding due to gastrointestinal telangiectatic anomalies, pulmonary arteriovenous malformations, hepatopulmonary syndrome, and retinal vessel abnormalities are being reported in patients with telomere biology disorders (TBDs) more frequently than previously described. The international clinical care consortium of telomere-associated ailments and family support group Dyskeratosis Congenita Outreach, Inc. held a workshop on vascular abnormalities in the TBDs at the National Cancer Institute in October 2017. Read More

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http://dx.doi.org/10.1007/s10456-018-9640-7DOI Listing
February 2019
7 Reads

Intellectual Disability and Psychotropic Medications.

J Dev Behav Pediatr 2018 Sep;39(7):591-593

Division of Developmental Behavioral Pediatrics, University of Michigan Medical School, Ann Arbor, MI.

Case: Andrew is a 17-year-old male with trisomy 21, commonly known as Down syndrome, and accompanying severe intellectual disability who presents to your primary care office with his father for the first time to establish care and assistance with transition. Andrew has a history of a complete atrioventricular canal that was repaired as an infant and poorly controlled infantile spasms. Currently, he struggles with constipation, esophageal strictures, medullary nephrocalcinosis, urinary retention, sleep dysregulation, G-tube dependency, and hip dysplasia. Read More

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http://Insights.ovid.com/crossref?an=00004703-900000000-9926
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http://dx.doi.org/10.1097/DBP.0000000000000613DOI Listing
September 2018
23 Reads

Risk factors of long hospital stay for immunoglobulin A vasculitis: Single-center study.

Pediatr Int 2018 Oct;60(10):918-922

Department of Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.

Background: Immunoglobulin A (IgA) vasculitis is a common, systemic childhood disease that occasionally interferes with oral intake of food and necessitates hospitalization. In Japan, there are no reports on the length of hospitalization or factors related to long-term hospitalization in children with IgA vasculitis. In this study, we investigated the factors related to long-term hospitalization. Read More

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http://dx.doi.org/10.1111/ped.13685DOI Listing
October 2018
12 Reads

Simultaneous Serial Transverse Enteroplasty (STEP) in Size Mismatch Small Bowel Transplantations.

J Gastrointest Surg 2018 Aug 8. Epub 2018 Aug 8.

Department of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.

Background: Small bowel transplantation (SBTX) in children receiving larger grafts from adults can be challenging because of size mismatch. The aim of the present study was to assess whether a simultaneous serial transverse enteroplasty (STEP) can address the problem of size mismatch.

Methods: Three different size ratio groups between donors and recipients were compared in a porcine model with a 14-day follow-up. Read More

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http://dx.doi.org/10.1007/s11605-018-3893-8DOI Listing
August 2018
4 Reads

Case 2: Hemolacria, Hematochezia, and Hematuria in an 11-month-old Boy.

Pediatr Rev 2018 Aug;39(8):418-420

Department of Pediatrics, Cohen Children's Medical Center at Northwell Health, New Hyde Park, NY.

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http://dx.doi.org/10.1542/pir.2016-0155DOI Listing
August 2018
2 Reads

Small intestine polypoid arteriovenous malformation: a stepwise approach to diagnosis in a paediatric case.

BMJ Case Rep 2018 Jul 24;2018. Epub 2018 Jul 24.

Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

We report a case of acute gastrointestinal haemorrhage due to a small intestine polypoid arteriovenous malformation (AVM) in a patient with a remote history of obscure gastrointestinal bleeding (OGIB) 8 years earlier. The diagnosis of a small intestine AVM was made using video capsule endoscopy (VCE) and confirmed using single-balloon push enteroscopy. The lesion was marked with submucosal tattoo to aid in subsequent surgical resection of the lesion with primary duodenoduodenostomy. Read More

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http://dx.doi.org/10.1136/bcr-2018-224536DOI Listing
July 2018
4 Reads

Gastrointestinal Vascular Malformations in Patients with Turner's Syndrome: A Systematic Review of Case Reports.

Horm Res Paediatr 2018 24;90(1):39-43. Epub 2018 Jul 24.

Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warsaw, Poland.

Background/aim: There is a paucity of data on gastrointestinal (GI) vascular abnormalities in patients with Turner's syndrome (TS). Therefore, this literature review aimed to characterize the nature of GI vascular malformations in patients with TS, their localization in the GI tract, and their clinical and laboratory manifestations.

Methods: A systematic search for articles was conducted using Medline and Embase (until August 2017). Read More

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http://dx.doi.org/10.1159/000490425DOI Listing
December 2018
7 Reads

Evaluation of intestinal injury, inflammatory response and oxidative stress following intracerebral hemorrhage in mice.

Int J Mol Med 2018 Oct 4;42(4):2120-2128. Epub 2018 Jul 4.

Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.

Intestinal injury is a common complication following intracerebral hemorrhage (ICH), which leads to malnutrition, impaired immunity and unsatisfactory prognosis. Previous studies have revealed the pathogenesis of intestinal injury following traumatic brain injury using ischemic stroke models. However, the effects of ICH on intestinal injury remain unknown. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3755DOI Listing
October 2018
13 Reads

Medical Child Abuse: A Case Presenting as Anogenital Bleeding of Unknown Origin in an Older Child.

J Pediatr Adolesc Gynecol 2018 Dec 7;31(6):637-639. Epub 2018 Jul 7.

Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Background: Medical child abuse is a challenging diagnosis to make, particularly in older children with unusual presenting symptoms.

Case: A 7-year-old child with complex medical history presented with anogenital bleeding of unknown origin. Extensive laboratory testing, imaging studies, and diagnostic procedures were negative for any etiology. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10833188183025
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http://dx.doi.org/10.1016/j.jpag.2018.06.011DOI Listing
December 2018
13 Reads

Neutrophil-to-lymphocyte ratio to predict gastrointestinal bleeding in Henoch: Schönlein purpura.

Pediatr Int 2018 Sep 5;60(9):791-795. Epub 2018 Sep 5.

Department of Pediatrics, Chonnam National University Hospital, Gwangju, Korea.

Background: Henoch-Schönlein purpura (HSP) is a common form of vasculitis in children. It typically involves small vessels of the skin, the gastrointestinal (GI) tract, joints, and kidneys. GI involvement is the most severe short-term complication and GI bleeding is a major complication of HSP, but there is no established predictive marker of GI bleeding. Read More

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http://dx.doi.org/10.1111/ped.13652DOI Listing
September 2018
16 Reads

RBC Exposure in Pediatric Extracorporeal Membrane Oxygenation: Epidemiology and Factors Associated With Large Blood Transfusion Volume.

Pediatr Crit Care Med 2018 Aug;19(8):767-774

Department of Cardiology, Boston Children's Hospital, Boston, MA.

Objectives: To quantify and identify factors associated with large RBC exposure in children supported with extracorporeal membrane oxygenation.

Design: Retrospective cohort study.

Setting: Single tertiary care children's hospital. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001596DOI Listing
August 2018
8 Reads

A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review.

Medicine (Baltimore) 2018 Jun;97(22):e10873

Department of Pediatrics, West China Second University Hospital.

Rationale: Blue rubber bleb nevus syndrome (BRBNS) is a rare vascular disorder consisting of multifocal venous malformations. Delayed diagnosis or misdiagnosis frequently occurs in patients without typical cutaneous lesions or gastrointestinal bleeding symptoms. This article reports a 10-year case of delayed diagnosis of BRBNS detected by capsule endoscopy. Read More

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http://dx.doi.org/10.1097/MD.0000000000010873DOI Listing
June 2018
6 Reads

Acute Variceal Bleeding Causes Significant Morbidity.

J Pediatr Gastroenterol Nutr 2018 Sep;67(3):371-376

Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics.

Background And Aims: The need for primary prophylaxis of variceal bleeding in children is unclear due to insufficient evidence of the efficacy of prophylactic therapy and the mortality and morbidity associated with the first bleeding event. Previous studies have provided estimates of mortality. We aimed to investigate the morbidity associated with acute variceal bleeding (AVB) in children and to identify contributing factors. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002039DOI Listing
September 2018
8 Reads