1,311 results match your criteria Pediatrics Gastrointestinal Bleeding


Efficacy and safety of direct oral anticoagulants for treatment of left ventricular thrombus; a systematic review.

Acta Cardiol 2021 May 10:1-5. Epub 2021 May 10.

Department of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Michigan State University, Kalamazoo, MI, USA.

Introduction: Left ventricular thrombus (LVT) is a well-recognised complication of ischaemic and non-ischaemic heart disease. The incidence of this complication has drastically reduced due to reperfusion therapies. Current guidelines recommend using warfarin for at least three months. Read More

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Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance.

J Clin Oncol 2021 May 4:JCO2002636. Epub 2021 May 4.

Lebanese American University Medical Center-Rizk, Beirut, Lebanon.

Purpose: Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals.

Patients And Methods: Data were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium. Read More

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Diagnosis and management of extrahepatic oesophageal variceal bleed in children in a low resourced setting.

Ghana Med J 2020 Dec;54(4):274-278

Department of Child Health, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra.

Extrahepatic portal vein obstruction (EHPVO) is a major cause of portal hypertension (PH) in children. Portal vein thrombosis (PVT) is the most common cause accounting for up to 75% of cases in developing countries. Upper gastrointestinal bleeding is the most dreaded and commonest presentation of portal hypertension. Read More

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December 2020

Prescribing patterns, indications and adverse events of ibuprofen in children: results from a national survey among Italian pediatricians.

Ital J Pediatr 2021 Apr 21;47(1):98. Epub 2021 Apr 21.

Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Via S. Pansini, 5, 80131, Naples, Italy.

Background: Despite ibuprofen widely recognized safety profile, an increase of suspected adverse events has been reported in the last decade in parallel with its growing over-the-counter use. The aims of this study were to assess the therapeutic approach to the feverish child and to evaluate the main indications and the most frequent adverse events related to ibuprofen administration in children.

Methods: A specific questionnaire-form regarding the management of ibuprofen therapy in children was distributed among a sample of pediatricians all over the Italian territory between September and October 2020. Read More

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Association of Oral Corticosteroid Bursts With Severe Adverse Events in Children.

JAMA Pediatr 2021 Apr 19. Epub 2021 Apr 19.

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Importance: The adverse effects from the long-term use of oral corticosteroids are known, but, to our knowledge, few studies have reported the risk of corticosteroid bursts, particularly among children.

Objective: To quantify the associations of corticosteroid bursts with severe adverse events, including gastrointestinal (GI) bleeding, sepsis, pneumonia, and glaucoma, in children.

Design, Setting, And Participants: This cohort study used data derived from the National Health Insurance Research Database in Taiwan from January 1, 2013, to December 31, 2017, on children younger than 18 years of age and used a self-controlled case series design. Read More

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Maternal mesalazine-induced neonatal gastrointestinal bleeding.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Neonatology, Shikoku Medical Center for Children and Adults, Zentsuji, Kagawa, Japan.

Ulcerative colitis often develops in the reproductive age women and can cause exacerbation by pregnancy. Mesalazine (5-aminosalicylic acid) is recommended as a safe anti-inflammatory drug during pregnancy. However, maternal mesalazine is transferred to the fetus through the placenta and may cause allergic events. Read More

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Can Cost-effectiveness Analysis Inform Genotype-Guided Aspirin Use for Primary Colorectal Cancer Prevention?

Cancer Epidemiol Biomarkers Prev 2021 Apr 13. Epub 2021 Apr 13.

Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.

Background: Inherited genetic variants can modify the cancer-chemopreventive effect of aspirin. We evaluated the clinical and economic value of genotype-guided aspirin use for colorectal cancer chemoprevention in average-risk individuals.

Methods: A decision analytical model compared genotype-guided aspirin use versus no genetic testing, no aspirin. Read More

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"Endoshield": A Physical Protective Box for Pediatric Endoscopy during the COVID-19 Pandemic.

Clin Endosc 2021 Apr 1. Epub 2021 Apr 1.

Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand.

Background/aims: The coronavirus disease (COVID)-19 pandemic presents challenges for gastrointestinal endoscopy. Although the virus is transmitted through contact and droplets, aerosol-generating procedures produce aerosols that can spread through airborne routes. Several gastrointestinal societies have released statements to protect patients and health care providers (HCPs). Read More

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Acute Upper Gastrointestinal Bleeding in Hexagenerians or Older (≥60 Years) Versus Younger (<60 Years) Patients: Clinico-Endoscopic Profile and Outcome.

Cureus 2021 Feb 23;13(2):e13521. Epub 2021 Feb 23.

Internal Medicine, Dr. Sampurnanand Medical College, Jodhpur, IND.

Background and aims Acute upper gastrointestinal (UGI) bleeding is one of the serious and potentially life-threatening medical emergencies, causing significant mortality and morbidity. This study aimed to evaluate the clinico-endoscopic profile and outcome among patients aged <60 years who presented for UGI bleeding compared to those aged ≥60 years. Methods This prospective observational study was conducted among 194 patients who presented with symptoms or signs of UGI bleed. Read More

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February 2021

Twenty-four-hour pretreatment with low dose (0.25 mg/kg/dose) versus high dose (0.5 mg/kg/dose) dexamethasone in reducing the risk of postextubation airway obstruction in children: A randomized open-label noninferiority trial.

Pediatr Pulmonol 2021 Mar 25. Epub 2021 Mar 25.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objective: Multidose dexamethasone pretreatment reduces risk of postextubation airway obstruction (PEAO). However, its optimal dose is not known. We planned to compare 24 h pretreatment with low-dose dexamethasone (LDD) (0. Read More

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The Incidence of Erosive Esophagitis as a Complication of Pediatric Diabetic Ketoacidosis.

Case Rep Endocrinol 2021 5;2021:6636383. Epub 2021 Mar 5.

Division of Pediatric Endocrinology and Diabetes, Rhode Island Hospital, Providence, RI, USA.

Introduction: Gastrointestinal (GI) symptoms commonly occur during diabetic ketoacidosis (DKA) and typically resolve with treatment. However, GI complications can persist after DKA resolves. The incidence of upper GI bleeding during DKA in adults has been described, with erosive esophagitis one of the most common lesions. Read More

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Unusual cause of severe iron deficiency anaemia in a child: paraoesophageal hernia.

BMJ Case Rep 2021 Mar 4;14(3). Epub 2021 Mar 4.

Radiodiagnosis, AIIMS Rishikesh, Rishikesh, Uttarakhand, India.

Iron deficiency anaemia is a known complication of a large hiatal hernia in adults. It occurs as a result of erosions on the gastric mucosa secondary to traction at the hiatus during respiration and/or gastric acid-related injuries to the mucosa. Even though anaemia occurs as a result of chronic gastrointestinal blood loss, testing for faecal occult blood is often negative and upper gastrointestinal endoscopy normal as the bleeding is intermittent. Read More

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Clinical variability in multifocal lymphangioendotheliomatosis with thrombocytopenia: a review of the literature.

Pediatr Hematol Oncol 2021 May 27;38(4):367-377. Epub 2021 Feb 27.

Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.

Multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) is a recently recognized disorder characterized by vascular lesions marked by distinct endothelial proliferation. Lesions affect multiple tissues, and MLT can be associated with refractory thrombocytopenia resulting in life-threatening bleeding. Diagnosing MLT may be challenging given its rarity and phenotypic variability. Read More

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Transient abnormal myelopoiesis in pediatrics with trisomy 21.

Clin Case Rep 2021 Feb 29;9(2):605-608. Epub 2020 Nov 29.

Student of Research Committee Lorestan University of Medical Sciences Khorramabad Iran.

Transient abnormal myelopoiesis is common among Down syndrome patients. Although no therapeutic measures are required, close monitoring of comorbidities such as gastrointestinal bleeding is required. Long-term follow-up is promising for a healthy future and reduced requirement of unnecessary therapeutic measures including chemotherapy and remission of the pathology. Read More

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February 2021

Successful use of long-acting octreotide for protracted gastrointestinal bleeding related to protein-losing enteropathy after the Fontan procedure: a case report.

Cardiol Young 2021 Feb 16:1-3. Epub 2021 Feb 16.

Department of Paediatrics, The Jikei University School of Medicine, Tokyo, Japan.

Gastrointestinal bleeding complicated with protein-losing enteropathy after the Fontan procedure has been often reported in recent years, but there is no established therapy for it.We report the case of an 18-year-old boy who suffered from abdominal pain, melena, and anaemia due to intractable haemorrhagic protein-losing enteropathy after the Fontan procedure. He was successfully treated with octreotide therapy. Read More

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February 2021

Ruxolitinib-combined doxorubicin-etoposide-methylprednisolone regimen as a salvage therapy for refractory/relapsed haemophagocytic lymphohistiocytosis: a single-arm, multicentre, phase 2 trial.

Br J Haematol 2021 May 9;193(4):761-768. Epub 2021 Feb 9.

Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

We performed a multicentre, non-randomised trial (NCT03533790) to investigate the efficacy of ruxolitinib combined with the doxorubicin-etoposide-methylprednisolone (Ru-DEP) regimen as a salvage therapy for refractory/relapsed haemophagocytic lymphohistiocytosis (HLH). All patients failing to achieve a complete or partial response 2 weeks after initial HLH-94/HLH-04 regimen or relapsed after remission were enrolled in the study between June 2018 and June 2019. The efficacy was evaluated 2 weeks after initiating Ru-DEP salvage therapy. Read More

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Severe Liver Disorder Following Liver Transplantation in STING-Associated Vasculopathy with Onset in Infancy.

J Clin Immunol 2021 Feb 5. Epub 2021 Feb 5.

Division of Immunology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Purpose: STING-associated vasculopathy with onset in infancy (SAVI) is a type-I interferonopathy, characterized by systemic inflammation, peripheral vascular inflammation, and pulmonary manifestations. There are three reports of SAVI patients developing liver disease, but no report of a SAVI patient requiring liver transplantation. Therefore, the relevance of liver inflammation is unclear in SAVI. Read More

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February 2021

Gastroenterology manifestations and COVID-19 outcomes: A meta-analysis of 25,252 cohorts among the first and second waves.

J Med Virol 2021 05 23;93(5):2740-2768. Epub 2021 Feb 23.

Division of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.

A meta-analysis was performed to identify patients with coronavirus disease 2019 (COVID-19) presenting with gastrointestinal (GI) symptoms during the first and second pandemic waves and investigate their association with the disease outcomes. A systematic search in PubMed, Scopus, Web of Science, ScienceDirect, and EMBASE was performed up to July 25, 2020. The pooled prevalence of the GI presentations was estimated using the random-effects model. Read More

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Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis.

Cochrane Database Syst Rev 2021 Jan 26;1:CD011561. Epub 2021 Jan 26.

Gastroenterology and Nutrition Department, Division of Paediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including bleeding (haemorrhage) from oesophageal and gastrointestinal varices. Variceal bleeding commonly occurs in children and adolescents with chronic liver disease or portal vein thrombosis. Prevention is, therefore, important. Read More

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January 2021

Beta-blockers versus placebo or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis.

Cochrane Database Syst Rev 2021 Jan 26;1:CD011973. Epub 2021 Jan 26.

Gastroenterology and Nutrition Department, Division of Paediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including haemorrhage from oesophageal and gastrointestinal varices. Variceal haemorrhage commonly occurs in children with chronic liver disease or portal vein thrombosis. Therefore, prevention is important. Read More

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January 2021

Point-of-Care Laboratory Data Collection During Critical Care Transport.

Air Med J 2021 Jan-Feb;40(1):81-83. Epub 2020 Nov 3.

Duke University Hospital, Durham, NC.

Objective: Critical care transport involves a high level of intensive clinical care in a resource-limited environment. These patients require multiple assessments guiding specialty treatments, including blood product administration, intravenous electrolyte replacement, ventilator management, and extracorporeal membrane oxygenation. This study aims to measure the usage of point-of-care (POC) laboratory data during critical care transport. Read More

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November 2020

Indomethacin for symptomatic patent ductus arteriosus in preterm infants.

Cochrane Database Syst Rev 2021 01 15;1:CD013133. Epub 2021 Jan 15.

Departments of Pediatrics, Community Health & Epidemiology, Dalhousie University & IWK Health Centre, Halifax, Canada.

Background: Symptomatic patent ductus arteriosus (PDA) is associated with mortality and morbidity in preterm infants. In these infants, prophylactic use of indomethacin, a non-selective cyclooxygenase inhibitor, has demonstrated short-term clinical benefits. The effect of indomethacin in preterm infants with a symptomatic PDA remains unexplored. Read More

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January 2021

Meckel's diverticulum in adults: seldom suspected and frequently found.

J Investig Med 2021 Mar 18;69(3):789-791. Epub 2020 Dec 18.

Children's Hospital Association, Overland Park, Kansas, USA.

Meckel's diverticulum (MD) is a well-defined diagnosis in children presenting with either bleeding or obstruction. Although anecdotally adult patients may present with complications from MD, their presentation seems to be different, with a reported predominance of non-bleed-related presentations. Reports in this population, however, are limited, and little is known of the epidemiology of MD in older patients. Read More

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Postoperative Intestinal Fistula in Primary Advanced Ovarian Cancer Surgery.

Cancer Manag Res 2021 6;13:13-23. Epub 2021 Jan 6.

Multidisciplinary Unit of Abdominal Pelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, Castellón, Spain.

Background: Advanced ovarian cancer (AOC) requires an aggressive surgery with large visceral resections in order to achieve an optimal or complete cytoreduction and increase the patient's survival. However, the surgical aggressiveness in the treatment of AOC is not exempt from major complications, such as the gastrointestinal fistula (GIF), which stands out among others due to its high morbidity and mortality.

Methods: We evaluated the clinicopathological features in patients with AOC and their association with GI. Read More

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January 2021

Severe Enteritis as the Sole Manifestation of Novel Coronavirus Disease 2019 (COVID-19) in Adolescent Patients.

Case Rep Infect Dis 2020 23;2020:8823622. Epub 2020 Dec 23.

Pediatric Infectious Diseases, Department of Pediatrics, St. Joseph's Children's Hospital, 703 Main Street, Paterson, New Jersey 07503, USA.

Enteritis as the only manifestation of novel coronavirus disease 2019 (COVID-19) in adolescents without features of multisystem inflammatory syndrome in children (MIS-C) or a prior history of inflammatory bowel disease (IBD) has not been described. We report two adolescent patients (a 14-year-old male and a 20-year-old pregnant female) presenting to tertiary-care centers in the United States with severe enteritis as the only manifestation of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The patients were hospitalized with acute abdominal pain and gastrointestinal (GI) bleeding, with no evidence of MIS-C, and were previously healthy with no history of IBD. Read More

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December 2020

Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study.

Am J Gastroenterol 2021 05;116(5):1044-1052

State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Introduction: Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic venous malformation (VM) disease. The characteristic gastrointestinal (GI) bleeding from multiple VM lesions causes severe chronic anemia which renders most patients depend on lifelong blood transfusion and frequent endoscopic treatment with dismayed outcomes. Although recent case reports suggest that oral sirolimus (rapamycin) is effective, a comprehensive evaluation of its efficacy and safety is in need. Read More

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Eosinophilic colitis in children: a new and elusive enemy?

Pediatr Surg Int 2021 Apr 7;37(4):485-490. Epub 2021 Jan 7.

Pediatric Surgery Unit, Department of Maternal and Child Health, Fondazione IRCCS-Policlinico San Matteo, Pavia, Italy.

Purpose: Eosinophilic gastrointestinal disorders are rare in children and present with a broad spectrum of non-specific symptoms. To date, no guidelines for diagnosis, therapy and follow-up are validated. Aim of our study is to focus on eosinophilic colitis (EC), to determine a possible correlation between associated disorders, macroscopic findings and treatment/follow up. Read More

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Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor.

In Vivo 2021 Jan-Feb;35(1):81-93

Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background/aim: Inflammatory fibroid polyp (IFP) is a rare, usually solitary and intraluminal polypoid benign tumor that can affect any part of the gastrointestinal (GI) tract, although in the majority of cases it affects the stomach. This lesion is characterized by proliferation of highly vascular fibrous tissue and infiltration by a variable number of different inflammatory cells. Its etiology is unknown. Read More

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September 2020