9,825 results match your criteria Pediatrics Gastroenteritis


Trends in Pediatric Primary Care Visits during the COVID-19 Pandemic.

Acad Pediatr 2021 May 10. Epub 2021 May 10.

Department of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. Electronic address:

Objective: Months after the declaration of the COVID-19 national emergency, visits among children remained suppressed for unclear reasons, which we sought to understand by examining child visit rates.

Methods: Using de-identified claims data for children <18 years old from OptumLabs® Data Warehouse, a large commercial claims database, we compared monthly primary care visit and vaccination rates from January-October 2020 to January-October 2018 and 2019. Visit rates were analyzed by visit reason and by the month after (e. Read More

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Retraction Note: Childhood iron deficiency anemia leads to recurrent respiratory tract infections and gastroenteritis.

Sci Rep 2021 May 11;11(1):10421. Epub 2021 May 11.

Department of Microbiology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.

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Epidemiology and genetic diversity of group A rotaviruses in pre-vaccination period in Thailand, 2018-2019.

Infect Genet Evol 2021 May 7:104898. Epub 2021 May 7.

Department of Microbiology, Chiang Mai University, Chiang Mai, Thailand; Emerging and Re-emerging Diarrheal Viruses Cluster, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Group A rotaviruses (RVAs) are the major viruses that cause acute gastroenteritis in young children worldwide. The objective of this study was to investigate the prevalence and genotype diversity of RVAs circulating in children with acute gastroenteritis in Thailand before the implementation of RVA vaccine in the childhood immunization programme. A total of 1170 stool specimens were obtained in 2018-2019 from children admitted to hospitals with diarrhea and screened for RVAs by nested RT-PCR. Read More

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Rotavirus disease and health care utilisation among children under 5 years of age in highly developed countries: A systematic review and meta-analysis.

Vaccine 2021 Apr 29. Epub 2021 Apr 29.

Institute of Social and Preventive Medicine, University of Bern, Mittlestrasse 43, 3012 Bern, Switzerland; Paediatric Respiratory Medicine, Children's University Hospital of Bern, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland. Electronic address:

Background: Rotavirus (RV) infection is the leading cause of diarrhoea-associated morbidity and mortality globally among children under 5 years of age. RV vaccination is available, but has not been implemented in many national immunisation plans, especially in highly developed countries. This systematic review aimed to estimate the prevalence and incidence of health care use for RV gastroenteritis (RVGE) among children aged under 5 years in highly developed countries without routine RV vaccination. Read More

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Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses.

Viruses 2021 Apr 22;13(5). Epub 2021 Apr 22.

Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.

Astroviruses are single stranded, positive-sense RNA viruses that have been historically associated with diseases of the gastrointestinal tract of vertebrates, including humans. However, there is now a multitude of evidence demonstrating the capacity of these viruses to cause extraintestinal diseases. The most striking causal relationship is neurological diseases in humans, cattle, pigs, and other mammals, caused by astrovirus infection. Read More

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Rotavirus Strain Distribution before and after Introducing Rotavirus Vaccine in India.

Pathogens 2021 Apr 1;10(4). Epub 2021 Apr 1.

The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore 632004, India.

In April 2016, an indigenous monovalent rotavirus vaccine (Rotavac) was introduced to the National Immunization Program in India. Hospital-based surveillance for acute gastroenteritis was conducted in five sentinel sites from 2012 to 2020 to monitor the vaccine impact on various genotypes and the reduction in rotavirus positivity at each site. Stool samples collected from children under 5 years of age hospitalized with diarrhea were tested for group A rotavirus using a commercial enzyme immunoassay, and rotavirus strains were characterized by RT-PCR. Read More

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Apolipoprotein E variants correlate with the clinical presentation of paediatric inflammatory bowel disease: A cross-sectional study.

World J Gastroenterol 2021 Apr;27(14):1483-1496

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań 60-572, Poland.

Background: It has been suggested that apolipoprotein E ( polymorphisms are associated with the risk of developing inflammatory bowel disease (IBD) and the early age of disease onset. However, there are no reports regarding the relationship with clinical characteristics and disease severity.

Aim: To summarise that APOE polymorphisms are associated with the risk of developing IBD and the early age of disease onset. Read More

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Gut Microbiota Characteristics in Children After the Use of Proton Pump Inhibitors.

Turk J Gastroenterol 2021 Jan;32(1):70-75

Division of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University School of Medicine, Thailand.

Background/aims: Prolonged acid suppression from proton pump inhibitor (PPI) has been shown to cause gut microbiota alteration which may increase risk of various infections in adults. We aimed to characterize gut microbiota profiles in children after a short-term use of PPI.

Materials And Methods: Children aged 1-18 years who underwent PPI therapy were included during April-December 2017. Read More

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January 2021

Phylogenetic molecular evolution and recombination analysis of complete genome of human parechovirus in Thailand.

Sci Rep 2021 Apr 21;11(1):8572. Epub 2021 Apr 21.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Human parechovirus (HPeV), which is a member of the Picornavirus group of viruses, is a pathogen that is reported to be associated with manifestations that include respiratory tract involvement, gastroenteritis, sepsis-like symptom, and central nervous system complication. Until now, nineteen genotypes have been identified. The lack of proofreading property of viral RNA-dependent RNA polymerase (RdRp) together with recombination among the intra- and inter-genotypes of the virus results in high diversity. Read More

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Prevalence, Clinical Characteristics and Changes of Antibiotic Resistance in Children with Nontyphoidal Infections from 2009-2018 in Chongqing, China.

Infect Drug Resist 2021 13;14:1403-1413. Epub 2021 Apr 13.

Department of Gastroenterology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.

Purpose: Nontyphoidal (NTS) is a leading bacterial cause for acute gastroenteritis in children. With the increasing use of antibiotics worldwide, antibiotic resistance has become a global problem. However, data on NTS infections and changes in antibiotic resistance among children remain limited in China. Read More

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Study on the effectiveness and safety of Xingpi Yanger granule combined with Saccharomyces boulardii for rotavirus enteritis in children: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25593

Department of Pediatrics, Haikou Hospital of the Matemal and Child Health, NO.6 Wentan Road, Guoxing Avenue, Qiongshan District, Haikou City, Hainan Province, China.

Background: To systematically evaluate the effectiveness and safety of traditional Chinese medicine preparation XPYEG combined with SBI and SBI alone in the treatment of REC, and to provide the reference in drugs for the clinical treatment of children with rotavirus enteritis.

Methods: Retrieving the English databases: PubMed, Cochrane Library and Embase; Chinese databases: CNKI, CBM and WANFANG Data. Retrieving a randomized controlled trial of XPYEG and SBI in the treatment of REC. Read More

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Effect of Lactobacillus reuteri LRE02-Lactobacillus rhamnosus LR04 combination and gastrointestinal functional disorders in an Emergency Department pediatric population.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3097-3104

Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: Probiotics are living microorganisms that, when administered per os in adequate amounts, may confer a health benefit on the host by the regularization of an unbalanced gastroenteric microbiota. The objective of this study was to evaluate treatment effectiveness, safety, and palatability of a probiotic's combination (Lactobacillus reuteri LRE02-DSM 23878 and Lactobacillus rhamnosus LR04-DSM 16605) in a pediatric Emergency Department setting with functional gastrointestinal disorders.

Patients And Methods: Three groups were enrolled: children with functional abdominal pain; children with gastroenteritis; children with gas colic. Read More

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Variables Associated With Intravenous Rehydration and Hospitalization in Children With Acute Gastroenteritis: A Secondary Analysis of 2 Randomized Clinical Trials.

JAMA Netw Open 2021 Apr 1;4(4):e216433. Epub 2021 Apr 1.

Sections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatric Medicine, Alberta Children's Hospital, Alberta, Canada.

Importance: Despite guidelines endorsing oral rehydration therapy, intravenous fluids are commonly administered to children with acute gastroenteritis in high-income countries.

Objective: To identify factors associated with intravenous fluid administration and hospitalization in children with acute gastroenteritis.

Design, Setting, And Participants: This study is a planned secondary analysis of the Pediatric Emergency Research Canada (PERC) and Pediatric Emergency Care Applied Research Network (PECARN) probiotic trials. Read More

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Rotavirus vaccination in Japan: Efficacy and safety of vaccines, changes in genotype, and surveillance efforts.

J Infect Chemother 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, 060-8543, Japan.

In Japan, a monovalent rotavirus vaccine (RV1) and a pentavalent rotavirus vaccine (RV5) were launched as voluntary vaccinations in November 2011 and July 2012, respectively. Rotavirus (RV) vaccine coverage in Japan increased from 30.0% in 2012 to 78. Read More

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associated mucositis.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Emergency Service, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

A 9-year-old boy presented to the emergency department of a paediatric hospital with non-painful lesions on his lips and inside his mouth, associated with lip swelling. On examination, his oral mucosa and lips showed numerous blisters with yellowish serofibrinous content and lip oedema. An eye examination revealed bilateral conjunctival injection. Read More

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Maternal mesalazine-induced neonatal gastrointestinal bleeding.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Neonatology, Shikoku Medical Center for Children and Adults, Zentsuji, Kagawa, Japan.

Ulcerative colitis often develops in the reproductive age women and can cause exacerbation by pregnancy. Mesalazine (5-aminosalicylic acid) is recommended as a safe anti-inflammatory drug during pregnancy. However, maternal mesalazine is transferred to the fetus through the placenta and may cause allergic events. Read More

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Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.

BMC Gastroenterol 2021 Apr 13;21(1):167. Epub 2021 Apr 13.

Department of Gastroenterology, Children's Hospital of Fudan University, 399 Wanyuan Road, Minhang District, Shanghai, 201102, China.

Background: Defects in interleukin 10 (IL10) and its receptors are particularly involved in very early onset inflammatory bowel disease (VEOIBD). However, large fragment deletions of IL10 receptor A (IL10RA) are rare.

Methods: VEOIBD patients with confirmed mutations in the IL10RA gene were enrolled from January 1, 2019 to June 30, 2020. Read More

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Telemedicine Medical Screening Evaluation Expedites the Initiation of Emergency Care for Children.

Pediatr Emerg Care 2021 Apr 9. Epub 2021 Apr 9.

From the *Division of Pediatric Emergency Medicine, Department of Pediatrics, New York City Health and Hospitals, Jacobi Medical Center; Division of Pediatric Emergency Medicine Departments of †Emergency Medicine ‡Pediatrics §Department of Emergency Medicine, NewYork-Presbyterian, Weill Cornell Medicine, New York, NY.

Objective: Prior studies show that staffing a physician at triage expedites care in the emergency department. Our objective was to describe the novel application and effect of a telemedicine medical screening evaluation (Tele-MSE) at triage on quality metrics in the pediatric emergency department (PED).

Methods: We conducted a retrospective quasi-experimental pre-post intervention study of patients presenting to an urban PED from December 2017 to November 2019 who received a Tele-MSE at triage. Read More

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Molecular characterization of the first human G15 rotavirus strain of zoonotic origin from the bovine species.

J Gen Virol 2021 Apr;102(4)

Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.

Group A rotaviruses (RVAs) infect a wide variety of mammalian and avian species. Animals act as a potential reservoir to RVA human infections by direct virion transmission or by contributing genes to reassortants. Here, we report the molecular characterization of a rare human RVA strain Ni17-46 with a genotype G15P[14], isolated in Japan in 2017 during rotavirus surveillance in a paediatric outpatient clinic. Read More

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Invasive salmonellosis in paediatric patients in the Northern Territory, Australia, 2005-2015.

J Paediatr Child Health 2021 Apr 13. Epub 2021 Apr 13.

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Aim: To describe the epidemiology of invasive Salmonella disease in children in the Northern Territory, Australia.

Methods: Design: A retrospective review of invasive salmonellosis cases identified by pathology records and the Northern Territory Notifiable Disease Surveillance System. Case definitions: Those aged 18 years or under, with Salmonella cultured from a usually sterile site, collected in the Northern Territory between 1 July 2005 and 30 June 2015. Read More

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Fatal case of hospital-acquired hypernatraemia in a neonate: lessons learned from a tragic error.

Clin Kidney J 2021 Apr 6;14(4):1277-1283. Epub 2020 Jul 6.

Division of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

A 3-week-old boy with viral gastroenteritis was by error given 200 mL 1 mmol/mL hypertonic saline intravenously instead of isotonic saline. His plasma sodium concentration (PNa) increased from 136 to 206 mmol/L. Extreme brain shrinkage and universal hypoperfusion despite arterial hypertension resulted. Read More

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[Role of fecal calprotectin in the diagnosis of neonatal necrotizing enterocolitis: a Meta analysis].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):381-389

Department of Pediatrics, First Hospital of Hebei Medical University, Shijiazhuang 050030, China.

Objective: To study the value of fecal calprotectin (FC) in the diagnosis of neonatal necrotizing enterocolitis (NEC) through a Meta analysis.

Methods: Web of Science, Cochrane Library, PubMed, Embase, China National Knowledge Infrastructure, Weipu Periodical Database, Wanfang Data, Chinese Biomedical Literature Database were searched for related studies published up to May 2020, with manual search as supplementation. The QUADAS criteria were used to evaluate the quality of the articles included. Read More

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How COVID-19 pandemic influences paediatric acute appendicitis cases?

Orv Hetil 2021 04 7;162(16):608-610. Epub 2021 Apr 7.

1 Heim Pál Országos Gyermekgyógyászati Intézet, Sebészeti és Traumatológiai Osztály, Budapest, Üllői út 86., 1089.

Összefoglaló. Bevezetés: A COVID-19-pandémia miatt a gyermekkori appendicitisek kezelésében számos változás történt (laparoszkópia helyett nyílt műtét, antibiotikumkezelés). Világszerte emelkedett a szövődményes appendicitisek aránya. Read More

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Worse impact of second wave COVID-19 pandemic in adults but not in children with inflammatory bowel disease: an Italian single tertiary center experience.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2744-2747

Divisions of Gastroenterology and Pediatrics, "Casa Sollievo della Sofferenza" Hospital, IRCCS, San Giovanni Rotondo (FG), Italy.

Objective: From September 2020, a second wave of COVID-19 pandemic started. We aimed at exploring the impact of SARS-CoV-2 infection in IBD patients during the two waves.

Patients And Methods: All IBD patients with a confirmed diagnosis of SARS-CoV-2 infection were enrolled. Read More

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Paediatrics: how to manage viral gastroenteritis.

Drugs Context 2021 26;10. Epub 2021 Mar 26.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Viral gastroenteritis is the most common diarrhoeal disorder seen in general practice and emergency departments. This article aims to provide a narrative updated review on the evaluation and management of viral gastroenteritis in children.

Methods: A PubMed search was performed with Clinical Queries using the key term 'viral gastroenteritis'. Read More

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Impact of SARS-CoV-2 pandemic on emergency department activity at the pediatric surgery unit of a third-level hospital.

Cir Pediatr 2021 Apr 1;34(2):85-89. Epub 2021 Apr 1.

Pediatric Surgery Unit. La Paz Pediatric Hospital, Madrid (Spain). La Paz Biomedical Research Institute (IdiPaz), Maternal, Child, and Development Health (SAMID) network.

Introduction: As a result of the emergence of the SARS-CoV-2 respiratory virus in Wuhan in December 2019, the Spanish Government declared the state of emergency with restrictions such as stay-at-home lockdown. The objective of this study was to analyze emergency activity at a referral pediatric surgery unit in its territory and determine whether surgical pathologies had decreased or not.

Methods: A retrospective study of pediatric patients presenting at the emergency department and referred to the pediatric surgery unit from March 14, 2020 to April 20, 2020 was carried out. Read More

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Effectiveness of probiotics and synbiotics in reducing duration of acute infectious diarrhea in pediatric patients in developed countries: a systematic review and meta-analysis.

Eur J Pediatr 2021 Apr 6. Epub 2021 Apr 6.

Department of Pediatrics, Venizeleion General Hospital of Heraklion, 71409, Heraklion, Crete, Greece.

Acute diarrhea is one of the most frequent causes of doctor visits and hospital admissions for children. Our objective was to evaluate the association between probiotics administration and reduction of acute infectious diarrhea duration in children dwelling in developed countries. Bibliographic databases, gray literature, and reference lists were searched up to September 29, 2019. Read More

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Rotavirus Genotype Trends and Gastrointestinal Pathogen Detection in the United States, 2014-16: Results from the New Vaccine Surveillance Network.

J Infect Dis 2021 Apr 2. Epub 2021 Apr 2.

Centers for Disease Control and Prevention, Atlanta, Georgia, United States.

Background: Following the implementation of rotavirus vaccination in 2006, severe acute gastroenteritis (AGE) due to group A rotavirus (RVA) has substantially declined in USA (US) children. We report the RVA genotype prevalence as well as co-infection data from seven US New Vaccine Surveillance Network (NVSN) sites during three consecutive RVA seasons, 2014-2016.

Methods: A total of 1041 stool samples that tested positive for RVA by Rotaclone enzyme immunoassay (EIA) were submitted to the Centers for Disease Control and Prevention (CDC) for RVA genotyping and multipathogen testing. Read More

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Characterisation of a G2P[4] Rotavirus Outbreak in Western Australia, Predominantly Impacting Aboriginal Children.

Pathogens 2021 Mar 16;10(3). Epub 2021 Mar 16.

Enteric Diseases Group, Murdoch Children's Research Institute, Parkville 3052, Australia.

In May, 2017, an outbreak of rotavirus gastroenteritis was reported that predominantly impacted Aboriginal children ≤4 years of age in the Kimberley region of Western Australia. G2P[4] was identified as the dominant genotype circulating during this period and polyacrylamide gel electrophoresis revealed the majority of samples exhibited a conserved electropherotype. Full genome sequencing was performed on representative samples that exhibited the archetypal DS-1-like genome constellation: G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 and phylogenetic analysis revealed all genes of the outbreak samples were closely related to contemporary Japanese G2P[4] samples. Read More

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Benign Convulsions with Mild Rotavirus and Norovirus Gastroenteritis: Nationwide Data from the Health Insurance Review and Assessment Service in South Korea.

Children (Basel) 2021 Mar 30;8(4). Epub 2021 Mar 30.

Department of Pediatrics, Inha University School of Medicine, Incheon 22332, Korea.

There have been no large-scale studies on the epidemiology of benign convulsions with mild gastroenteritis (CwG) since the introduction of the rotavirus vaccine in South Korea in 2007. This study aimed to analyze the trends in rotavirus gastroenteritis (RVGE) and rotavirus-associated CwG (RaCwG) after rotavirus vaccination. Further, we aimed to analyze changes in norovirus gastroenteritis (NVGE) and norovirus-associated CwG (NaCwG) using nationwide data from the Korean Health Insurance Review and Assessment Service. Read More

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