8,005 results match your criteria Pediatrics Gastroenteritis


Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.

PLoS Pathog 2019 Apr 24;15(4):e1007709. Epub 2019 Apr 24.

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed that protective STAT1 signaling controls viral replication and pathogenesis, but the immune mechanisms that noroviruses exploit to induce pathology are elusive. Here, we show that gastrointestinal MNV infection leads to widespread IL-1β maturation in MNV-susceptible STAT1-deficient mice. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007709DOI Listing

Infection Triggering Acute Relapse in Pediatric Crohn's Disease.

Case Rep Infect Dis 2019 20;2019:2094372. Epub 2019 Mar 20.

Department of Pediatrics, Western University, London, Ontario, Canada N6A 3K7.

Crohn's disease exacerbations can often be associated with bacterial infections causing gastroenteritis. We report a child who experienced exacerbation of his Crohn's disease associated with a positive stool culture for . Endoscopy showed features of moderate inflammation similar to exacerbation of Crohn's disease. Read More

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http://dx.doi.org/10.1155/2019/2094372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446101PMC

Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium.

Am J Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Objectives: The literature related to eosinophilic gastritis (EG), gastroenteritis (EGE), and colitis (EC) is limited. We aimed to characterize rates of diagnosis, clinical features, and initial treatments for patients with EG, EGE, and EC.

Methods: In this retrospective study, data were collected from 6 centers in the Consortium of Eosinophilic Gastrointestinal Researchers from 2005 to 2016. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000228DOI Listing

Validation of parental reports of rotavirus vaccination of their children compared to the national immunization registry.

Vaccine 2019 Apr 16. Epub 2019 Apr 16.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. Electronic address:

Background: The introduction of rotavirus vaccines into national immunization programs necessitates vaccine effectiveness evaluations. Parental report of vaccination status is a simple and accessible source of information; however, its validity is unclear.

Aims: To validate parental reports of rotavirus immunization compared to documentation of vaccination in national immunization registry, and to assess vaccine effectiveness by each method. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193049
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http://dx.doi.org/10.1016/j.vaccine.2019.04.037DOI Listing
April 2019
1 Read

Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review.

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3963-xDOI Listing
April 2019
1 Read
2.613 Impact Factor

Comparative Evaluation of Enteric Bacterial Culture and a Molecular Multiplex Syndromic Panel in Children with Acute Gastroenteritis.

J Clin Microbiol 2019 Apr 10. Epub 2019 Apr 10.

Sections of Pediatric Emergency Medicine and Gastroenterology, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

: Although enteric multianalyte syndromic panels are increasingly employed, direct comparisons with traditional methods and the inclusion of host phenotype correlations are limited.: 3089 children with gastroenteritis submitted stool, rectal-swab specimens, and clinical data. Primary outcome was bacterial pathogen detection agreement for shared targets between culture and the Luminex xTAG® Gastrointestinal Pathogen Panel (GPP). Read More

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http://dx.doi.org/10.1128/JCM.00205-19DOI Listing
April 2019
2 Reads

[What have we learnt about rotavirus in Spain in the last 10 years?]

An Pediatr (Barc) 2019 Apr 7. Epub 2019 Apr 7.

Servicio de Pediatría, Hospital Clínico Universitario, Santiago de Compostela, España.

Introduction: Vaccines against rotavirus (RV) have been available in Spain since 2006, but they are neither recommended nor financed by the National Health System. Nevertheless, through recommendations of the Spanish Association of Paediatrics vaccination has achieved intermediate coverage.

Material And Methods: A systematic literature review was performed on studies carried out in Spain in the last 12 years (2006-2018) on RV infection and vaccination. Read More

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http://dx.doi.org/10.1016/j.anpedi.2019.01.024DOI Listing
April 2019
1 Read

Efficacy of phenobarbital for benign convulsions with mild gastroenteritis: A randomized, placebo-controlled trial.

Brain Dev 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatrics, Japanese Red Cross Society Himeji Hospital, Hyogo, Japan.

Objective: This study was performed to evaluate the efficacy and safety of intravenous phenobarbital (PB) for benign convulsions with mild gastroenteritis (CwG).

Methods: A randomized, single-blind, placebo-controlled trial involving patients with CwG was conducted at the Japanese Red Cross Society Himeji Hospital. Patients with CwG who had experienced two or more seizures were eligible. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.03.014DOI Listing
April 2019
1 Read

No evidence of increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel.

Hum Vaccin Immunother 2019 Apr 4. Epub 2019 Apr 4.

a Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine , Tel Aviv University , Ramat Aviv, Tel Aviv , Israel.

Following the introduction of universal immunization against rotavirus, concerns were raised regarding pathogen-replacement of rotavirus by norovirus. The study aim was to examine the incidence and characteristics and norovirus gastroenteritis before and after the introduction of universal rotavirus immunization in Israel. We studied 1179 stool samples collected between November 2007 and December 2014 for a prospective hospital-based surveillance study of children aged 0-59 months hospitalized for gastroenteritis. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1
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http://dx.doi.org/10.1080/21645515.2019.1599522DOI Listing
April 2019
4 Reads

Pigment Visibility on Rectal Swabs Used to Detect Enteropathogens: A Prospective Cohort Study.

J Clin Microbiol 2019 Apr 3. Epub 2019 Apr 3.

Sections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Data are lacking regarding the impact of visible pigment on rectal swab diagnostic accuracy. We describe the test characteristics of rectal swabs with and without pigment in children with gastroenteritis. Between December 2014 and September 2017, children <18 years with ≥3 episodes of vomiting and/or diarrhea in a 24-hour period and symptoms <7 days were enrolled through two pediatric emergency departments, and from a province-wide nursing telephone advice line in Alberta, Canada. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.00213-19
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http://dx.doi.org/10.1128/JCM.00213-19DOI Listing
April 2019
2 Reads

Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter Injury in Newborns.

Neuropediatrics 2019 Apr 2. Epub 2019 Apr 2.

Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.

Recent reports have suggested an association between rotavirus infection and a distinctive pattern of white matter injury (WMI) in neonates with seizures; however, the connection between the two is not fully understood. To evaluate the underlying mechanism, we profiled and compared eight cytokines (IL [interleukin]-1, IL-6, IL-8, IL-10, IFN- [interferon- ], MCP-1 [monocyte chemoattractant protein-1], MIP-1 [macrophage inflammatory protein-1], and TNF- [tumor necrosis factor-]) in the cerebrospinal fluid (CSF) of 33 neonates with seizures who had no other well-known causes of seizures and 13 control patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 neonates with seizures, 9 showed WMI and all were infected with rotavirus (R + W + ). Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1677516
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http://dx.doi.org/10.1055/s-0038-1677516DOI Listing
April 2019
8 Reads

Diagnostic accuracy of pediatric atypical appendicitis: Three case reports.

Medicine (Baltimore) 2019 Mar;98(13):e15006

Department of Pediatrics, Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital.

Rationale: Acute appendicitis is one of the most common causes of acute abdomen in children, yet it is difficult to diagnose in young children because its clinical manifestations may be atypical. Here, 3 atypical clinical cases associated with appendicitis in children are reported.

Patient Concern: The 1st case corresponds to a 5-year-old male patient who presented with abdominal discomfort, intermittent fevers, and vomiting, have increased white blood cell (WBC) count and C-reactive protein (CRP). Read More

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http://dx.doi.org/10.1097/MD.0000000000015006DOI Listing
March 2019
3 Reads

Three case reports of collagenous gastritis in children: Lessons for an endoscopic and histologic approach to mucosal nodularity of the stomach.

Medicine (Baltimore) 2019 Mar;98(11):e14870

Department of Pediatrics, Kangwon National University School of Medicine, Chuncheon, Republic of Korea.

Rationale: Collagenous gastritis (CG) is a rare form of chronic gastritis defined histologically by a thickened subepithelial collageneous band in the lamina propria. However, the clinical features and endoscopic findings of CG have not been clearly established in the pediatric population.

Presenting Concerns: We report the cases of 3 children who presented with intractable anemia and minimal or no gastrointestinal (GI) symptoms and were followed up without definitive diagnosis determination even through diagnostic endoscopic evaluations. Read More

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http://dx.doi.org/10.1097/MD.0000000000014870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426568PMC
March 2019
7 Reads
5.723 Impact Factor

Impaired Health-Related Quality of Life in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Impact of Core Symptoms.

Front Pediatr 2019 15;7:26. Epub 2019 Feb 15.

Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

The objectives of this study were to compare the health-related quality of life (HRQOL) of a North American population of adolescents and young adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to (1) healthy controls (HC), (2) adolescents with ME/CFS in other countries, and (3) other forms of pediatric chronic illness, and (4) to examine the influence of the core illness symptoms in the Institute of Medicine (IOM) case definition on impaired HRQOL. Cross-sectional study comparing individuals with ME/CFS referred to a tertiary care Chronic Fatigue clinic and HC. Eligible participants were age 10-30 years and met the Fukuda criteria for CFS. Read More

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http://dx.doi.org/10.3389/fped.2019.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385524PMC
February 2019
1 Read

Anti-NMDA receptor encephalitis in a toddler: A diagnostic challenge.

Int J Pediatr Adolesc Med 2018 Jun 30;5(2):75-77. Epub 2018 Apr 30.

Distinguished Professor of Pediatrics and Infectious Disease, Department of Pediatrics, Faculty of Medicine, The University of Jordan, Amman, Jordan.

Anti N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder and is considered to be one of the most common causes of encephalitis in children. Despite the fact that around half of all reported cases are of children, the number of studies that report infants and toddlers is very small. Furthermore, reports on children from the Middle East particularly are extremely rare. Read More

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http://dx.doi.org/10.1016/j.ijpam.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363247PMC
June 2018
3 Reads

A nationwide survey of norovirus-associated encephalitis/encephalopathy in Japan.

Brain Dev 2019 Mar;41(3):263-270

Department of Pediatrics, Juntendo University Faculty of Medicine, Japan.

Background: Norovirus is a major pathogen of gastroenteritis and is known to cause encephalitis/encephalopathy. The aim of this national survey was to clarify the clinical features of norovirus-associated encephalitis/encephalopathy (NoVE) among children in Japan.

Methods: A nationwide survey of children with NoVE was conducted using a structured research form. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.11.001DOI Listing
March 2019
2 Reads

Kommerell Diverticulum: Right Aortic Arch with Anomalous Origin of Left Subclavian Artery and Duplicity of Right Vertebral Artery in a 16-Year-Old Girl.

Am J Case Rep 2019 Feb 21;20:228-232. Epub 2019 Feb 21.

Departmet of Catdiology, Universidade Nove de Julho, São Paulo, SP, Brazil.

BACKGROUND Kommerell diverticulum with a right-sided aortic arch is a rare congenital anatomical condition most often observed in adults. A possible etiology of the subclavian artery's anomalous origin would be an abnormality in regression of the fourth primitive aortic arch during embryonic development. CASE REPORT We report on the case of a 16-year-old female patient presenting with complaints of occasional tachycardia and mild non-specific dyspnea after anxiety crises. Read More

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http://dx.doi.org/10.12659/AJCR.912053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394145PMC
February 2019
1 Read

Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study.

Hum Vaccin Immunother 2019 Feb 20:1-9. Epub 2019 Feb 20.

h Medicines Development Division , GSK , Tokyo , Japan.

Rotavirus infections have been reported to account for 40-50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
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http://dx.doi.org/10.1080/21645515.2018.1564441DOI Listing
February 2019
10 Reads

Eosinophilic Gastrointestinal Diseases in Childhood.

Ann Nutr Metab 2018 19;73 Suppl 4:18-28. Epub 2019 Feb 19.

Division on Gastroenterology, Hepatology and Nutrition, First Department of Pediatrics, University of Athens, Children's Hospital "Agia Sofia", Athens, Greece,

Eosinophilic gastrointestinal diseases (EGIDs) comprise a group of chronic, inflammatory diseases of the gastrointestinal (GI) tract, that are characterized, clinically, by symptoms related to the dysfunction of the involved segment(s) of the GI tract, and histologically, by dense eosinophilic inflammation, in the absence of an identifiable secondary cause. The group of EGIDs comprises eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC). EoE is the most common and the best described EGID compared to EG, EGE, and EC. Read More

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http://dx.doi.org/10.1159/000493668DOI Listing
February 2019
2 Reads

Changes in norovirus genotype diversity in gastroenteritis outbreaks in Alberta, Canada: 2012-2018.

BMC Infect Dis 2019 Feb 19;19(1):177. Epub 2019 Feb 19.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

Background: The emergence of norovirus genotype GII.4 variants has been associated with gastroenteritis pandemics worldwide, prompting molecular surveillance for early detection of novel strains. In this study, we aimed to analyze the outbreak activity of norovirus and characterize the norovirus strains circulating in Alberta between July 2012 and February 2018. Read More

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http://dx.doi.org/10.1186/s12879-019-3792-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381812PMC
February 2019
1 Read

The impact of allergic rhinitis on gastrointestinal disorders among young adults.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

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http://dx.doi.org/10.1111/jep.13108DOI Listing
February 2019
2 Reads

Cannabis, a potential treatment option in pediatric IBD? Still a long way to go.

Expert Rev Clin Pharmacol 2019 Apr 26;12(4):355-361. Epub 2019 Feb 26.

b Department of Paediatric Gastroenterology , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.

Introduction: The onset of inflammatory bowel disease (IBD) in children is rising. Current treatment options are based on immunomodulatory therapy. Alternative treatment options are upcoming since they appear to be effective in individual patients. Read More

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http://dx.doi.org/10.1080/17512433.2019.1582330DOI Listing
April 2019
3 Reads

Equity and impact: Ontario's infant rotavirus immunization program five years following implementation. A population-based cohort study.

Vaccine 2019 Apr 11;37(17):2408-2414. Epub 2019 Feb 11.

Public Health Ontario, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Background: Ontario implemented a publicly-funded rotavirus (RV) immunization program in 2011. Our objectives were to evaluate its impact on hospitalizations and emergency department (ED) visits for acute gastroenteritis (AGE) five years after implementation.

Methods: We performed a population-based longitudinal retrospective cohort study to identify hospitalizations and ED visits for RV-AGE and overall AGE in all age groups using ICD-10 codes between August 1, 2005 and March 31, 2016. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.061DOI Listing
April 2019
1 Read
3.624 Impact Factor

Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pa.

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http://dx.doi.org/10.1016/j.jaip.2019.01.053DOI Listing
February 2019
10 Reads

Prevalence, levels and seasonal variations of human enteric viruses in six major rivers in Alberta, Canada.

Water Res 2019 Apr 1;153:349-356. Epub 2019 Feb 1.

Department of Paediatrics, University of Alberta, 1405-87 Ave, Edmonton, AB, T6G 1C9, Canada.

The prevalence and seasonal variation of 7 viruses in 6 major rivers in Alberta were assessed using a combination of qPCR, cell culture and integrated cell culture with qPCR (ICC-qPCR). Water samples were collected monthly from rivers at different sites upstream and downstream of major urban centers. Seven viruses including rotavirus, adenovirus, astrovirus, norovirus, sapovirus, JC virus and enterovirus, were detected in at least one of the water samples at each site using qPCR. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.034DOI Listing
April 2019
4 Reads

A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots.

Front Immunol 2019 25;10:58. Epub 2019 Jan 25.

Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare condition of primary immunodeficiency disorder. Interleukin-12 receptor β1 (IL12RB1) deficiency, is the most common genetic etiology of MSMD, which is characterized by the selective predisposition to clinical disease caused by weakly-virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccines, and environmental non-tuberculous mycobacteria (NTM). To the best of our knowledge, this is the first case of deficiency to be reported from Iraq. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355664PMC
January 2019
4 Reads

Diagnostic challenges in late-presenting congenital diaphragmatic hernia: a 16-year experience from tertiary care centre in North India.

Trop Doct 2019 Feb 10:49475519827109. Epub 2019 Feb 10.

3 Professor, Department of Paediatrics, PGIMS, Rohtak, Haryana, India.

With increasing use of ultrasound screening, the prenatal diagnosis of congenital diaphragmatic hernia (CDH) in better resourced areas has become the norm. However, early diagnosis is still not universal in resource-poor settings and late presentations of CDH continue. We retrospectively analysed the medical records of children operated for late-presenting CDH from 2001 to 2016 at our tertiary care centre in North India. Read More

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http://dx.doi.org/10.1177/0049475519827109DOI Listing
February 2019
4 Reads

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis.

Ital J Pediatr 2019 Feb 6;45(1):23. Epub 2019 Feb 6.

University of Trieste, Piazzale Europa, 1, 34127, Trieste, Italy.

Background: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. Read More

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http://dx.doi.org/10.1186/s13052-019-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366080PMC
February 2019
11 Reads

Does the addition of dextrose to IV crystalloid therapy provide clinical benefit in acute dehydration? A systematic review and meta-analysis.

CJEM 2019 Jan 30:1-8. Epub 2019 Jan 30.

†Department of Emergency Medicine,Indiana University School of Medicine,Indianapolis, IN.

Objectives: Intravenous dextrose aids in the resolution of ketosis in dehydrated patients not tolerating oral glucose and is often recommended in this clinical scenario. Our aim was to determine whether the addition of dextrose to intravenous rehydration solutions results in decreased hospital admissions or other clinically important benefits among dehydrated children or adults.

Methods: MEDLINE, EMBASE, Web of Science, SCOPUS, and the Cochrane Library were searched by a medical librarian from inception through November 2017. Read More

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http://dx.doi.org/10.1017/cem.2018.500DOI Listing
January 2019
5 Reads

[Educational intervention in Primary Care to reduce and improve the adequacy of pediatric consultations].

Rev Esp Salud Publica 2019 Jan 29;93. Epub 2019 Jan 29.

Centro de Salud Medina del Campo. Valladolid. España.

Objective: Many parents visit paediatric health services due to unimportant reasons (ignorance of health problems of their children and psychosocial and emotional conditionings). The objective was to determine the effectiveness of a health education program, on the number and adequacy of pediatric consultations, in the first 6 months of the child´s life.

Methods: Quasi-experimental study of an educational intervention aimed at pregnant women in the last trimester of pregnancy and their partners. Read More

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January 2019
3 Reads

Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2-5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study.

Lancet Respir Med 2019 Apr 24;7(4):325-335. Epub 2019 Jan 24.

Division of Respiratory Diseases, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Background: The efficacy, safety, and tolerability of lumacaftor and ivacaftor are established in patients aged 6 years and older with cystic fibrosis, homozygous for the F508del-CFTR mutation. We assessed the safety, pharmacokinetics, pharmacodynamics, and efficacy of lumacaftor and ivacaftor in children aged 2-5 years.

Methods: In this multicentre, phase 3, open-label, two-part study, we enrolled children aged 2-5 years, weighing at least 8 kg at enrolment, with a confirmed diagnosis of cystic fibrosis who were homozygous for the F508del-CFTR mutation. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30460-0DOI Listing
April 2019
2 Reads

Missed Diagnosis of New-Onset Systolic Heart Failure at First Presentation in Children with No Known Heart Disease.

J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics, Section of Pediatric Cardiology, Baylor College of Medicine, Houston, TX.

Objective: To determine frequency of missed heart failure diagnosis at first presentation among children with no known heart disease admitted with new-onset heart failure.

Study Design: Using a retrospective design, we reviewed electronic medical records of all patients aged <21 years with no known heart disease, hospitalized with new-onset heart failure during 2003-2015 at a tertiary-quaternary care institution. We assessed records for missed diagnosis of heart failure (primary outcome), associated process breakdowns, and clinical outcomes using a structured data collection instrument. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.029DOI Listing
January 2019
5 Reads
3.790 Impact Factor

The use of bedside echocardiography for measuring cardiac index and systemic vascular resistance in pediatric patients with septic shock.

Rev Bras Ter Intensiva 2018 Oct-Dec;30(4):460-470

Department of Pediatrics, Faculty of Medicine, Cairo University - Cairo, Egypt.

Objective: Follow-up of cardiac index and systemic vascular resistance index by bedside echocardiography until resuscitation.

Methods: A set of hemodynamic parameters was obtained, including cardiac output, stroke volume, cardiac index, systemic vascular resistance index, velocity time integral, myocardial performance index, capillary refill time, and heart rate at 0 hours after fluid boluses before the start of inotropes, and followed up after 6 hours and 24 hours.

Results: Included were 45 patients with community-acquired septic shock. Read More

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http://dx.doi.org/10.5935/0103-507X.20180067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334480PMC
April 2018
3 Reads

The International Collaborative on Fatigue Following Infection (COFFI).

Fatigue 2018 19;6(2):106-121. Epub 2018 Jan 19.

Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilizing COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF.

Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. Read More

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https://www.tandfonline.com/doi/full/10.1080/21641846.2018.1
Publisher Site
http://dx.doi.org/10.1080/21641846.2018.1426086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333416PMC
January 2018
15 Reads

Factors Associated With Rotavirus Vaccine Coverage.

Pediatrics 2019 Feb 17;143(2). Epub 2019 Jan 17.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Rotavirus vaccines (RVVs) were included in the US immunization program in 2006 and are coadministered with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine, yet their coverage lags behind DTaP. We assessed timing, initiation, and completion of the RVV series among children enrolled in active gastroenteritis surveillance at 7 US medical institutions during 2014-2016.

Methods: We compared coverage and timing of each vaccine series and analyzed characteristics associated with RVV initiation and completion. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1824DOI Listing
February 2019
16 Reads

A rare case report of fungal esophagitis combined with giant gastric ulcer in an immunocompetent patient.

Medicine (Baltimore) 2019 Jan;98(3):e14158

Department of Digestive Disease, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University.

Rationale: Fungal infection of gastrointestinal (GI) tract is usually seen in immunocompromised patients, but can rarely occur in immunocompetent people in whom no permissive factor is present.

Patient Concerns: We describe a 68-year-old male immunocompetent patient presenting with simultaneous fungal esophagitis and giant gastric ulcer.

Diagnoses: Repeated endoscopic biopsies were taken from the giant gastric ulcer edge and base and histology demonstrated granulation tissue and pseudohyphal fungal forms. Read More

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http://dx.doi.org/10.1097/MD.0000000000014158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370008PMC
January 2019
12 Reads

Acute Infectious Diarrhea.

Adv Exp Med Biol 2019 Jan 17. Epub 2019 Jan 17.

Department of Translational Medical Sciences - Section of Pediatrics, University of Naples Federico II, Naples, Italy.

Acute infectious diarrhea (AID) is one of the most common diseases in pediatric age with relevant burden both in high- and in low-income countries.Thanks to their direct action on enterocyte functions and indirect actions on mucosal and systemic immune system and intestinal microenvironment, probiotics are an ideal intervention to manage AID in childhood. However, their efficacy is strictly related to strains and indications, and practitioners should take this information into account in clinical practice. Read More

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http://link.springer.com/10.1007/5584_2018_320
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http://dx.doi.org/10.1007/5584_2018_320DOI Listing
January 2019
14 Reads

Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016.

BMC Public Health 2019 Jan 15;19(1):69. Epub 2019 Jan 15.

Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Background: In 2016, the Government of India introduced the oral rotavirus vaccine (ROTAVAC, Bharat Biotech, India) in 4 states of India as part of the Universal Immunization Programme, and expanded to 5 more states in 2017. We report four years of data on rotavirus gastroenteritis in hospitalized children < 5 years of age prior to vaccine introduction.

Methods: Children from 7 sites in southern and northern India hospitalized for diarrhoea were recruited between July 2012 and June 2016. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-6406-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334384PMC
January 2019
13 Reads

Gelatin tannate versus other antidiarrheal medication in children with acute gastroenteritis: a retrospective, observational study.

J Comp Eff Res 2019 Feb 15;8(3):187-194. Epub 2019 Jan 15.

Clinical Research & Regulatory Division, CEBIS International, Bucharest, Romania.

Aim: To evaluate the effectiveness and safety of gelatin tannate (GT) for acute gastroenteritis (AGE) in children.

Materials & Methods: In this retrospective, observational study, children admitted for AGE received GT ± oral rehydration solution (ORS; n = 46) or other antidiarrheal medications ± ORS (n = 46). Number and consistency of stools were recorded. Read More

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http://dx.doi.org/10.2217/cer-2018-0082DOI Listing
February 2019
5 Reads

GG can protect malnourished children.

Benef Microbes 2019 Apr 14;10(3):237-244. Epub 2019 Jan 14.

3 Department of Pediatrics, Regional Training and Research Hospital, 25280 Erzurum, Turkey.

Malnutrition affects virtually all organ systems, and malnourished children are more prone to infections. These children have dysbiosis, but probiotics can restore the disrupted gut microbiome. We investigated the protective effects of GG in malnourished children in terms of incidence of infection, and anthropometric and metabolic parameters. Read More

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http://dx.doi.org/10.3920/BM2018.0071DOI Listing
April 2019
1 Read

How Different is AMAN from AIDP in Childhood GBS? A Prospective Study from North India.

Indian J Pediatr 2019 Apr 12;86(4):329-334. Epub 2019 Jan 12.

Pediatric Neurology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Objectives: To compare the clinical profile and short-term outcome of children with axonal and demyelinating subtypes of childhood Guillain Barré syndrome (GBS).

Methods: This is a prospective observational study conducted in a tertiary care teaching hospital in North India. Consecutive children with Guillain Barré syndrome were recruited to compare the clinical profile and short term outcome among the subtypes. Read More

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http://dx.doi.org/10.1007/s12098-018-2835-5DOI Listing
April 2019
3 Reads
0.919 Impact Factor

Infantile-onset inflammatory bowel disease in a patient with Hermansky-Pudlak syndrome: a case report.

BMC Gastroenterol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.

Background: Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten genetic subtypes of this autosomal recessive condition have been described to date. Some patients with Hermansky-Pudlak syndrome type 1, 4, or 6 develop Crohn's-like inflammatory bowel disease at any age including early childhood, but most often in adolescence or young adulthood. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s12876-019-0929-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329123PMC
January 2019
15 Reads

Antiamoebic drugs for treating amoebic colitis.

Cochrane Database Syst Rev 2019 01 9;1:CD006085. Epub 2019 Jan 9.

Department of Pediatrics, University of the Philippines Manila College of Medicine-Philippine General Hospital, Taft Avenue, Manila, National Capital Region, Philippines, 1000.

Background: Infection with the protozoan Entamoeba histolytica is common in low- and middle-income countries, and up to 100,000 people with severe disease die every year. Adequate therapy for amoebic colitis is necessary to reduce illness, prevent development of complicated disease and extraintestinal spread, and decrease transmission.

Objectives: To evaluate antiamoebic drugs for treating amoebic colitis. Read More

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http://dx.doi.org/10.1002/14651858.CD006085.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326239PMC
January 2019
4 Reads

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II.

Front Microbiol 2018 18;9:3070. Epub 2018 Dec 18.

Graduate School of Health Sciences, Gunma Paz University, Takasaki, Japan.

Noroviruses are the leading cause of viral gastroenteritis in humans across the world. RNA-dependent RNA polymerase (RdRp) plays a critical role in the replication of the viral genome. Although there have been some reports on a limited number of genotypes with respect to the norovirus evolution of the region, no comprehensive molecular evolution examination of the norovirus GII genotype has yet been undertaken. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305289PMC
December 2018
3 Reads

Urological Problems in Patients with Menkes Disease.

J Korean Med Sci 2019 Jan 26;34(1):e4. Epub 2018 Dec 26.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Background: Menkes disease (MD) is a rare X-linked hereditary multisystemic disorder that is caused by dysfunction of copper metabolism. Patients with MD typically present with progressive neurodegeneration, some connective tissue abnormalities, and characteristic "kinky" hair. In addition, various types of urological complications are frequent in MD because of underlying connective tissue abnormalities. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2019.3
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http://dx.doi.org/10.3346/jkms.2019.34.e4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318444PMC
January 2019
13 Reads

IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission during Chronic Infection.

J Immunol 2019 Feb 7;202(3):956-965. Epub 2019 Jan 7.

The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada;

The cytokine IL-22 is rapidly induced at barrier surfaces where it regulates host-protective antimicrobial immunity and tissue repair but can also enhance disease severity in some chronic inflammatory settings. Using the chronic gastroenteritis model, Ab-mediated neutralization of IL-22 impaired intestinal epithelial barrier integrity and, consequently, exaggerated expression of proinflammatory cytokines. As disease normally resolved, neutralization of IL-22 caused luminal narrowing of the cecum-a feature reminiscent of fibrotic strictures seen in Crohn disease patients. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801308
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http://dx.doi.org/10.4049/jimmunol.1801308DOI Listing
February 2019
17 Reads

The epidemiology of non-viral gastroenteritis in New Zealand children from 1997 to 2015: an observational study.

BMC Public Health 2019 Jan 5;19(1):18. Epub 2019 Jan 5.

Department of Paediatrics, University of Otago, PO Box 4345, Christchurch Mail Centre, Christchurch, 8140, New Zealand.

Background: Acute gastroenteritis is a substantial cause of hospitalization in children. Shigella, Salmonella, Campylobacter, Yersinia, enterotoxigenic Escherichia coli (ETEC), Giardia and Cryptosporidium are gastrointestinal pathogens that are notifiable in New Zealand (NZ). The impact of these infections in the pediatric population has not yet been analyzed. Read More

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http://dx.doi.org/10.1186/s12889-018-6229-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321731PMC
January 2019
2 Reads

Appendicitis: Role of MRI.

Authors:
Manoj K Mittal

Pediatr Emerg Care 2019 Jan;35(1):63-66

Attending Physician, Pediatric Emergency Medicine, Children's Hospital of Philadelphia; Associate Professor of Clinical Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

The diagnosis of pediatric appendicitis can be difficult, with a substantial proportion misdiagnosed based on clinical features and laboratory tests alone. Accordingly, advanced imaging with ultrasound (US), computed tomography (CT), and/or magnetic resonance imaging has become routine for most children undergoing diagnostic evaluation for appendicitis. There is increasing interest in the use of US as the primary imaging modality and reserving CT as a secondary diagnostic modality in equivocal cases. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001710DOI Listing
January 2019
2 Reads

Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases.

Microbiome 2019 01 3;7(1). Epub 2019 Jan 3.

CEGIIR, University of Alberta, Edmonton, AB, T6G 2X8, Canada.

Background: Inflammatory bowel diseases (IBD) are a group of complex and multifactorial disorders with unknown etiology. Chronic intestinal inflammation develops against resident intestinal bacteria in genetically susceptible hosts. We hypothesized that host intestinal immunoglobulin (Ig) G can be used to identify bacteria involved in IBD pathogenesis. Read More

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http://dx.doi.org/10.1186/s40168-018-0604-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317230PMC
January 2019
3 Reads

Human bocavirus in children with acute gastroenteritis in Piedmont, Italy.

Minerva Pediatr 2019 Jan 2. Epub 2019 Jan 2.

Citoimmunodiagnostics Laboratory, Department of Public Health and Pediatric Sciences, Medical School, University of Turin, Turin, Italy.

Background: Gastroenteritis is a common disease in children, characterized by diarrhea, vomiting, abdominal pain, and fever. Co-detection of HBoV with other gastroenteric viruses was reported a lot in patients with acute gastroenteritis.

Methods: This paper presents the real-time RT-PCR Taqman assay for the detection and quantification of HBoV for clinical fecal samples collected from hospitalized children with acute gastroenteritis in Piedmont. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05365-3DOI Listing
January 2019
12 Reads