Search our Database of Scientific Publications and Authors

I’m looking for a

    1615 results match your criteria Pediatrics Fifth Disease or Erythema Infectiosum

    1 OF 33

    Focal segmental glomerulosclerosis in children complicated by posterior reversible encephalopathy syndrome.
    J Int Med Res 2018 Jan 1:300060517746559. Epub 2018 Jan 1.
    Department of Pediatrics, St. Maria Children's Hospital, University of Medicine and Pharmacy "Grigore T. Popa" Iasi, România.
    An uncommon side effect of cyclosporine A (CsA) use is posterior reversible encephalopathy syndrome (PRES). PRES usually develops because of disturbed capacity of posterior cerebral blood flow to autoregulate an acute rise in blood pressure. We present the case of a 10-year-old girl who was previously diagnosed in our department with focal segmental glomerulosclerosis. Read More

    Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis.
    Pediatr Neonatol 2017 Oct 19. Epub 2017 Oct 19.
    Department of Pediatrics, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address:
    Background: Adequate functions of immunoregulation, mediated by regulatory cells such as IL-10 producing CD19+CD38hiCD24hi transitional B cells (Trans), play an important role in control of excessive inflammatory response. Yet, the role of Trans in neonatal sepsis is incompletely understood. We investigated the role of Trans in late-onset sepsis (LOS). Read More

    Report of the 5th European expert meeting on rotavirus vaccination (EEROVAC).
    Hum Vaccin Immunother 2017 Dec 6:1-8. Epub 2017 Dec 6.
    a Julius Center for Health Sciences, University Medical Center Utrecht , Utrecht , The Netherlands.
    The Fifth European Expert Meeting on Rotavirus Vaccination was convened in Utrecht, The Netherlands, in March 2017. The 2-day meeting included invited lectures as well as original oral and poster presentations and brought together experts from 21 countries. Summary findings of the meeting include: Rotavirus vaccination programmes in Europe have resulted in reductions of 60-90% in rotavirus outpatient visits and hospitalizations. Read More

    Validity of a continuous metabolic syndrome score as an index for modeling metabolic syndrome in children and adolescents: the CASPIAN-V study.
    Diabetol Metab Syndr 2017 9;9:89. Epub 2017 Nov 9.
    Child Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: The purpose of the present study was to assess the validity of continuous metabolic syndrome score (cMetS) for predicting metabolic syndrome (MetS) and to determine the cutoff values in a representative sample of Iranian children and adolescents.

    Methods: This national study was conducted among 3843 students, aged 7-18 years country during the fifth survey of a national school-based surveillance program. The cMetS was computed by standardizing the residuals of waist circumference, mean arterial blood pressure, high-density lipoprotein cholesterol, triglycerides, and glucose by regressing them according to age and sex and aggregating them. Read More

    Preterm Birth Associated With Group B Streptococcus Maternal Colonization Worldwide: Systematic Review and Meta-analyses.
    Clin Infect Dis 2017 Nov;65(suppl_2):S133-S142
    Global Alliance to Prevent Prematurity and Stillbirth, Seattle, Washington.
    Background: Preterm birth complications are the leading cause of deaths among children <5 years of age. Studies have suggested that group B Streptococcus (GBS) maternal rectovaginal colonization during pregnancy may be a risk factor for preterm delivery. This article is the fifth of 11 in a series. Read More

    Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?
    Epilepsy Behav 2018 Jan 31;78:302-312. Epub 2017 Oct 31.
    Brain Repair Center, Life Science Research Institute, Dalhousie University, Room 229, PO Box 15000, Halifax, NS B3H4R2, Canada. Electronic address:
    There is common agreement that many disorders of the central nervous system are 'complex', that is, there are many potential factors that influence the development of the disease, underlying mechanisms, and successful treatment. Most of these disorders, unfortunately, have no cure at the present time, and therapeutic strategies often have debilitating side effects. Interestingly, some of the 'complexities' of one disorder are found in another, and the similarities are often network defects. Read More

    EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis.
    Allergy 2017 Sep 23. Epub 2017 Sep 23.
    Department of Women and Child Health, Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, University of Padua, Padua, Italy.
    Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Read More

    Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress.
    Biomed Pharmacother 2017 Nov 6;95:1177-1186. Epub 2017 Oct 6.
    Department of Dermatology, Hainan Provincial Dermatology Disease Hospital, 15 LongKun-Nan Road, Haikou 570206, China. Electronic address:
    Curcumin, a polyphenol compound, possesses potent pharmacological properties in preventing cancers, which make it as a potential anti-cancer mediator. However, it is still unknown that whether Curcumin induced melanoma A375 cell was associated with oxidative stress. Here, we firstly found a fascinating result that Curcumin could reduce the proliferation and induced apoptosis of human melanoma A375 cells. Read More

    Analysis of Epidemiology and Risk Factors of Atopic Dermatitis in Korean Children and Adolescents from the 2010 Korean National Health and Nutrition Examination Survey.
    Biomed Res Int 2017 22;2017:5142754. Epub 2017 Aug 22.
    Department of Pediatrics, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
    Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease, but only few studies involved samples of children and adolescents that are representative of the entire Korean population. This study aimed to estimate the prevalence and risk factors of AD among children and adolescents in Korea by using nationally representative data.

    Methods: We used data from the fifth Korean National Health and Nutrition Examination Survey in 2010 and retrospectively evaluated 2,116 children and adolescents. Read More

    Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis.
    Braz J Med Biol Res 2017 Aug 31;50(10):e6148. Epub 2017 Aug 31.
    Department of Pediatrics, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. Read More

    LDL cholesterol level in fifth-grade schoolchildren associates with stature.
    J Lipid Res 2017 Nov 4;58(11):2197-2201. Epub 2017 Sep 4.
    Department of Pediatrics, West Virginia University School of Medicine, Morgantown, WV.
    Short stature is associated with increased LDL-cholesterol levels and coronary artery disease in adults. We investigated the relationship of stature to LDL levels in children in the West Virginia Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project to determine whether the genetically determined inverse relationship observed in adults would be evident in fifth graders. A cross-sectional survey of schoolchildren was assessed for cardiovascular risk factors. Read More

    Natural History of Aromatic L-Amino Acid Decarboxylase Deficiency in Taiwan.
    JIMD Rep 2017 Aug 31. Epub 2017 Aug 31.
    Department of Pediatrics and Medical Genetics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Objectives: Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare inherited disorder of monoamine neurotransmitter synthesis; this deficiency leads to psychomotor delay, hypotonia, oculogyric crises, dystonia, and extraneurological symptoms. This study aimed to provide further insight into the clinical course of AADC deficiency in Taiwan.

    Patients And Methods: We present a retrospective, descriptive, single-center study of 37 children with a confirmed diagnosis of AADC deficiency. Read More

    Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine.
    Sci Rep 2017 Aug 23;7(1):9214. Epub 2017 Aug 23.
    Fifth Affiliated Hospital, Sun Yat-sen University-BGI Laboratory, Department of Experimental Medicine, The Fifth Affiliated Hospital,Sun Yat-sen University, Zhuhai, China.
    SLC10A1 codes for the sodium-taurocholate cotransporting polypeptide (NTCP), which is a hepatocellular transporter for bile acids (BAs) and the receptor for hepatitis B and D viruses. NTCP is also a target of multiple drugs. We aimed to evaluate the medical consequences of the loss of function mutation p. Read More

    History of parvovirus B19 infection is associated with silent cerebral infarcts.
    Pediatr Blood Cancer 2018 Jan 17;65(1). Epub 2017 Aug 17.
    Department of Medicine and Pediatrics, Vanderbilt-Meharry Sickle Cell Center of Excellence, Vanderbilt University Medical Center, Nashville, Tennessee.
    Background: The relationship between silent cerebral infarcts (SCIs) and history of parvovirus B19 (B19V) has not been systematically evaluated. As an ancillary study from the Silent Cerebral Infarct Trial (SIT) (NCT00072761), we tested the hypothesis that a history of B19V infection is associated with an increased prevalence of SCIs in children with sickle cell anemia.

    Procedure: We used a retrospective cross-sectional cohort study design; each participant underwent a brain magnetic resonance imaging (MRI) scan and medical record review for prior B19V infection (n = 958). Read More

    Scrub Typhus as an Etiology of Acute Febrile Illness in Gorakhpur, Uttar Pradesh, India, 2016.
    Am J Trop Med Hyg 2017 Nov 18;97(5):1313-1315. Epub 2017 Aug 18.
    National Institute of Epidemiology, Chennai, India.
    Seasonal outbreaks of acute encephalitis syndrome (AES) with high mortality occur every year in Gorakhpur region of Uttar Pradesh, India. Earlier studies indicated the role of scrub typhus as the important etiology of AES in the region. AES cases were hospitalized late in the course of their illness. Read More

    Autism Spectrum Disorder in Fragile X Syndrome: Cooccurring Conditions and Current Treatment.
    Pediatrics 2017 Jun;139(Suppl 3):S194-S206
    Departments of Pediatrics, Neurological Sciences, and Biochemistry, Rush University Medical Center, Chicago, Illinois.
    Background And Objective: Individuals with fragile X syndrome (FXS) are frequently codiagnosed with autism spectrum disorder (ASD). Most of our current knowledge about ASD in FXS comes from family surveys and small studies. The objective of this study was to examine the impact of the ASD diagnosis in a large clinic-based FXS population to better inform the care of people with FXS. Read More

    Germline EMSY sequence alterations in hereditary breast cancer and ovarian cancer families.
    BMC Cancer 2017 Jul 24;17(1):496. Epub 2017 Jul 24.
    Institute of Biosciences and Medical Technology - BioMediTech, University of Tampere, Lääkärinkatu 1, FI-33520, Tampere, Finland.
    Background: BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susceptibility in high-risk Finnish hereditary breast and ovarian cancer (HBOC) families. EMSY is located in the breast cancer-associated chromosomal region 11q13. The EMSY gene encodes a BRCA2-interacting protein that has been implicated in DNA damage repair and genomic instability. Read More

    Prevalence of Persistent Renal Dysfunction in Perinatally HIV-infected Thai Adolescents.
    Pediatr Infect Dis J 2018 Jan;37(1):66-70
    From the The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Excellence center in Pediatric Infectious Diseases and Vaccines, Chulalongkorn University, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, and Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Background: Persistent renal dysfunction (PRD) has been reported in up to 22% of perinatally HIV-infected adolescents (PHAs) in the United States and Europe. There are limited data available on PRD among PHAs in resource-limited settings regarding access to antiretroviral therapy (ART) at more advanced HIV stages.

    Methods: We retrospectively described the prevalence of PRD and associated factors in a Thai PHA cohort. Read More

    The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.
    Am J Respir Cell Mol Biol 2017 Dec;57(6):711-720
    4 Pulmonary and Respiratory Diseases, and.
    Cystic fibrosis (CF) remains the most lethal genetic disease in the Caucasian population. However, there is great variability in clinical phenotypes and survival times, even among patients harboring the same genotype. We identified five patients with CF and a homozygous F508del mutation in the CFTR gene who were in their fifth or sixth decade of life and had shown minimal changes in lung function over a longitudinal period of more than 20 years. Read More

    Immunohistochemical Demonstration of Parvovirus B19 Viral Protein 2 in Periflexural Exanthema in an Adult, Supporting Antibody-Dependent Enhancement as Means of Endothelial Uptake of the Virus.
    Am J Dermatopathol 2017 Jul 6. Epub 2017 Jul 6.
    Departments of *Pathology, †Dermatology, and ‡Internal Medicine, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; and §Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
    Human parvovirus B19 (B19V) causes a number of skin exanthemas and has been related to both cutaneous and systemic diseases. Tropism of the virus for the rapidly proliferating erythroid progenitor cells in the bone marrow and fetal liver explains the pathogenesis of anemia and fetal hydrops. The cutaneous lesions of erythema infectiosum and other B19V-related exanthemas have been attributed to the deposition of immune complexes in the skin. Read More

    Performance of Pediatric Risk of Mortality Score Among Critically Ill Children With Heart Disease.
    World J Pediatr Congenit Heart Surg 2017 07;8(4):427-434
    5 Division of Pediatric Cardiology, Department of Pediatrics, College of Medicine, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Objective: To evaluate the performance of the Pediatric Risk of Mortality 3 (PRISM-3) score in critically ill children with heart disease.

    Methods: Patients <18 years of age admitted with cardiac diagnoses (cardiac medical and cardiac surgical) to one of the participating pediatric intensive care units in the Virtual Pediatric Systems, LLC, database were included. Performance of PRISM-3 was evaluated with discrimination and calibration measures among both cardiac surgical and cardiac medical patients. Read More

    Early Desquamating Perineal Erythema in a Febrile Infant: A Characteristic Clinical Feature of Kawasaki Disease.
    Int J Environ Res Public Health 2017 Jun 30;14(7). Epub 2017 Jun 30.
    Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06132 Perugia, Italy.
    Background: The occurrence of a distinctive perineal eruption that appears early in infants with Kawasaki disease (KD), the most relevant type of febrile vasculitis of childhood, has received little attention in pediatric reports. KD diagnosis is based on clinical criteria, which can be supported by laboratory abnormalities or positive echocardiography findings: difficulty in diagnosis can be increased by incomplete or atypical presentations, but a timely diagnostic process is essential in the youngest patients who are more prone to the risk of cardiac sequelae resulting from KD. Case Presentation: In this report, we present the case of a 2-month-old infant with an unusual presentation of KD, in whom diagnosis was made despite fever remission on the fourth day of hospitalization following intravenous corticosteroid therapy to treat concomitant bronchoconstriction. Read More

    MicroRNA-122a Regulates Zonulin by Targeting EGFR in Intestinal Epithelial Dysfunction.
    Cell Physiol Biochem 2017 23;42(2):848-858. Epub 2017 Jun 23.
    Department of Center Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    Background/aims: This study aimed to investigate the role of microRNA (miR)-122a in regulating zonulin during the modulation of intestinal barrier.

    Methods: Zonulin proteins and their target gene expression were analyzed in miR-122a-overexpressing cell lines and in the target gene of epidermal growth factor receptor (EGFR). An mmu-miR-122a intestinal epithelial conditional transgenic (miR-122a-TG) mouse model was established to investigate EGFR and zonulin expression. Read More

    The Most Common Comorbidities in Dandy-Walker Syndrome Patients: A Systematic Review of Case Reports.
    J Child Neurol 2017 Sep 21;32(10):886-902. Epub 2017 Jun 21.
    1 Society of Junior Doctors, Athens, Greece.
    Objective: Dandy-Walker syndrome (DWS) is a rare neurologic multi-entity malformation. This review aimed at reporting its main nonneurologic comorbidities.

    Methods: Following PRISMA guidelines, search in Medline was conducted (2000-2014, keyword: dandy-walker). Read More

    Acute diplopia in the pediatric Emergency Department. A cohort multicenter Italian study.
    Eur J Paediatr Neurol 2017 Sep 3;21(5):722-729. Epub 2017 Jun 3.
    Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
    Background: Acute diplopia (AD) is an uncommon and distressing symptom of numerous ocular and neurological conditions, with potentially serious sequelaes. No data are present in pediatrics on the presentation and management of AD.

    Aim: This study investigated characteristics, etiology and health care utilization of the pediatric population with AD accessed to pediatric Emergency Departments (ED), trying to identify "red flags" associated with potentially life-threatening (LT) conditions. Read More

    Novel truncating variant in DNA2-related congenital onset myopathy and ptosis suggests genotype-phenotype correlation.
    Neuromuscul Disord 2017 Jul 6;27(7):616-618. Epub 2017 Apr 6.
    Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA, USA. Electronic address:
    DNA2 encodes a protein with nuclease, ATPase, and helicase domains, and serves to maintain mitochondrial DNA integrity. Mutations in DNA2 cause autosomal dominant progressive ophthalmoplegia with mitochondrial DNA deletions. This disorder was first reported in four patients with heterozygous, missense mutations in DNA2. Read More

    Attention Deficit Hyperactivity Disorder in Children With Sickle Cell Disease Referred for an Evaluation.
    J Pediatr Hematol Oncol 2017 Jul;39(5):350-354
    *Department of Pediatrics, Section of Hematology/Oncology, University of South Dakota Sanford School of Medicine, Sanford Children's Hospital, Sioux Falls, SD †Section of Pediatric Hematology ‡Department of Psychiatry and Behavioral Medicine §Department of Neurology ∥Section of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI.
    Neuropsychological deficits, including difficulties with attention, are well described in children with sickle cell disease (SCD). Very little is known about attention deficit hyperactivity disorder (ADHD) in children with SCD. The objective of this study was to determine the proportion of ADHD in children with SCD referred for neuropsychological evaluation. Read More

    Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis.
    Case Reports Hepatol 2017 20;2017:1359486. Epub 2017 Apr 20.
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan.
    Human parvovirus (HPV) B19 is linked to a variety of clinical manifestations, such as erythema infectiosum, nonimmune hydrops fetalis, and transient aplastic anemia. Although a few cases have shown HPVB19 infection as a possible causative agent for hepatitis-associated aplastic anemia (HAAA) in immunocompetent patients, most reported cases of HAAA following transient hepatitis did not have delayed remission. Here we report a rare case of severe aplastic anemia following acute hepatitis with prolonged jaundice due to HPVB19 infection in a previously healthy young male. Read More

    First-Line Antiretroviral Treatment Outcomes and Durability in HIV-Infected Children Treated Through the Universal Coverage Health Program in Thailand.
    J Acquir Immune Defic Syndr 2017 Jun;75(2):219-225
    *HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; †Kirby Institute, University of New South Wales, Sydney, Australia; ‡Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; §Research Unit in Pediatric Infectious Diseases and Vaccines, Chulalongkorn University, Bangkok, Thailand; ‖Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute of Global Health and Development, Amsterdam, the Netherlands; ¶Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; #The HIV/AIDS, Tuberculosis and Infectious Diseases Program, National Health Security Office (NHSO), Bangkok, Thailand; and **Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: We assessed the treatment outcomes on first-line antiretroviral therapy (ART), and factors associated with switching regimen in HIV-infected children treated through the universal coverage health program (UC) in Thailand.

    Methods: Children aged <15 years at ART initiation who had been receiving ART for at least 6 months between 2008 and 2014 through UC were included in the analysis. The Kaplan-Meier method was used to estimate immunological recovery (IMR), immunological failure, and virological failure (VF). Read More

    Genotype 1 of human parvovirus B19 in clinical cases.
    Rev Assoc Med Bras (1992) 2017 Mar;63(3):224-228
    PhD, Scientific Researcher, Núcleo de Doenças Respiratórias, Instituto Adolfo Lutz, São Paulo, SP, Brazil.
    Introduction:: Virus surveillance strategies and genetic characterization of human parvovirus B19 (B19V) are important tools for regional and global control of viral outbreak. In São Paulo, Brazil, we performed a study of B19V by monitoring the spread of this virus, which is an infectious agent and could be mistakenly reported as a rash and other types of infection.

    Method:: Serum samples were subjected to enzyme immunoassay, real time polymerase chain reaction, and sequencing. Read More

    Tumor treating fields in pediatric high-grade glioma.
    Childs Nerv Syst 2017 Jul 3;33(7):1043-1045. Epub 2017 May 3.
    Program in Neuro-Oncology, Center for Cancer and Blood Disorders, Children's Hospital Colorado, 12800 E. 19th Ave. RC1-N, Mail Stop 8302, Aurora, CO, 80045, USA.
    Purpose: Tumor treating fields (TTF) are alternating electric fields applied continuously to the scalp. The treatment is approved for both primary and recurrent supratentorial adult glioblastoma but unstudied in children.

    Methods: We report a feasibility case series of five pediatric high-grade glioma patients (ages 10-20 years) treated at our institution with TTF along with chemotherapy and/or radiation. Read More

    A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.
    Nat Commun 2017 Apr 20;8:14828. Epub 2017 Apr 20.
    Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.
    Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component. Here, we report a genome-wide association study that included 1,122 PBC cases and 4,036 controls of Han Chinese descent, with subsequent replication in a separate cohort of 907 PBC cases and 2,127 controls. Our results show genome-wide association of 14 PBC risk loci including previously identified 6p21 (HLA-DRA and DPB1), 17q12 (ORMDL3), 3q13. Read More

    Contribution of the TP53 R337H mutation to the cancer burden in southern Brazil: Insights from the study of 55 families of children with adrenocortical tumors.
    Cancer 2017 Aug 7;123(16):3150-3158. Epub 2017 Apr 7.
    Department of Global Medicine, International Outreach Program, St Jude Children's Research Hospital, Memphis, Tennessee.
    Background: The tumor protein p53 (TP53) arginine-to-histidine mutation at codon 337 (R337H) predisposes children to adrenocortical tumors (ACTs) and, rarely, to other childhood tumors, but its impact on adult cancer remains undetermined. The objective of this study was to investigate the frequency and types of cancer in relatives of children with ACT who carry the TP53 R337H mutation.

    Methods: TP53 R337H testing was offered to relatives of probands with ACT. Read More

    NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease.
    Mediators Inflamm 2017 28;2017:8316560. Epub 2017 Feb 28.
    Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai 200011, China.
    Background and Aims. The nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role in glomerular injury and tubulointerstitial fibrosis is still undefined. The present study was performed to identify the function of NLRP3 in modulating renal injury and fibrosis and the potential involvement of mitochondrial dysfunction in the murine unilateral ureteral obstruction (UUO) model of CKD. Read More

    sRAGE Is Elevated in the Lungs of Premature Infants Receiving Mechanical Ventilation.
    Am J Perinatol 2017 Jul 20;34(9):911-917. Epub 2017 Mar 20.
    Division of Neonatal Medicine, Department of Pediatrics, University of Mississippi, Jackson, Mississippi.
    Background Soluble receptor for advanced glycation end-products (sRAGE), a soluble isoform of the RAGE receptor, is elevated in lungs from patients with acute conditions such as acute respiratory distress syndrome and bronchiolitis. This study investigated whether sRAGE is present in ventilated infants. Methods Tracheal aspirates from the first week or the fifth week of life were obtained from intubated very low birth weight subjects and analyzed by Western blot. Read More

    Methodology and Early Findings of the Fifth Survey of Childhood and Adolescence Surveillance and Prevention of Adult Noncommunicable Disease: The CASPIAN-V Study.
    Int J Prev Med 2017 23;8. Epub 2017 Jan 23.
    Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: This paper presents the methodology and early findings of the fifth survey of a school-based surveillance program in Iran.

    Methods: This nationwide study was conducted in 2015 as the fifth survey of a surveillance program entitled "Childhood and Adolescence Surveillance and PreventIon of Adult Non- communicable disease" (CASPIAN-V) study. The protocol was mainly based on the World Health Organization-Global School student Health Survey. Read More

    Risk Factors for Health Care-Associated Bloodstream Infections in a Neonatal Intensive Care Unit.
    Iran J Pediatr 2016 Oct 27;26(5):e5213. Epub 2016 Jul 27.
    Clinical Microbiology and Infectious Disease, Medical Faculty, Dicle University, Diyarbakir, Turkey.
    Background: Healthcare-associated bloodstream infections (HCA-BSI) are a major cause of morbidity and mortality in neonatal intensive care units (NICUs).

    Objectives: We aimed to determine the causative organisms and risk factors of HCA-BSIs in NICUs.

    Methods: This study was performed between January 2011 and December 2014 in the neonatal intensive care unit of Dicle university, Turkey. Read More

    Ischemic stroke in Kawasaki disease.
    Pediatr Int 2017 Jan;59(1):92-96
    Division of Pediatric Cardiology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Pediatric stroke is considered to be rare. Stroke resulting from cerebral vasculitis is also uncommon in young children. With the increasing prevalence of Kawasaki disease (KD) diagnosis, this acquired vasculitis has been reported with various clinical presentations including neurological symptoms. Read More

    Novel genetic loci associated with hippocampal volume.
    Nat Commun 2017 Jan 18;8:13624. Epub 2017 Jan 18.
    Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
    The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Read More

    Short-acting erythropoiesis-stimulating agents for anaemia in predialysis patients.
    Cochrane Database Syst Rev 2017 01 9;1:CD011690. Epub 2017 Jan 9.
    Sydney School of Public Health, The University of Sydney, Edward Ford Building A27, Sydney, NSW, Australia, 2006.
    Background: The benefits of erythropoiesis-stimulating agents (ESA) for chronic kidney disease (CKD) patients have been previously demonstrated. However, the efficacy and safety of short-acting epoetins administered at larger doses and reduced frequency as well as of new epoetins and biosimilars remains uncertain.

    Objectives: This review aimed to evaluate the benefits and harms of different routes, frequencies and doses of epoetins (epoetin alpha, epoetin beta and other short-acting epoetins) for anaemia in adults and children with CKD not receiving dialysis. Read More

    Congenital miliary tuberculosis in an 18-day-old boy.
    Korean J Pediatr 2016 Nov 30;59(Suppl 1):S64-S67. Epub 2016 Nov 30.
    Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.; Allergy and Immunology Center, Korea University, Seoul, Korea.
    Congenital tuberculosis (TB) is a rare disease that is associated with high mortality. Mycobacterium tuberculosis, the causative agent, may be transmitted from the infected mother to the fetus by the transplacental route or by aspiration of infected amniotic fluid. Clinical symptoms and signs are not specific. Read More

    Screening of renal dysfunction among Burkitt lymphoma survivors by novel markers.
    Hematology 2017 Jun 16;22(5):265-273. Epub 2016 Dec 16.
    a Faculty of Medicine , Zagazig University , Egypt.
    Background: Burkitt lymphoma (BL) represents the most common pathological type of non-Hodgkin lymphoma in our region. Recently, high success rates have been achieved in BL treatment. Little is known about long-term renal dysfunction in this vulnerable group. Read More

    Atypical Presentation and Treatment Response in a Child with Familial Hypercholesterolemia Having a Novel LDLR Mutation.
    JIMD Rep 2017 9;35:67-70. Epub 2016 Dec 9.
    Robarts Research Institute and Department of Medicine, Schulich School of Medicine, Western University, London, ON, Canada, N6A 5B7.
    Familial hypercholesterolemia (FH) is an autosomal codominantly inherited disease. The severity of clinical presentation depends on the zygosity of the mutations in the LDLR, APOB, or PCSK9 genes. The homozygous form (HoFH) is associated with high mortality rate by third decade of life, while individuals with HeFH begin to suffer from premature cardiovascular disease in fourth or fifth decade of life. Read More

    Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil.
    Braz J Infect Dis 2017 Jan - Feb;21(1):102-106. Epub 2016 Nov 30.
    Universidade Federal Fluminense, Faculdade de Medicina, Programa de Pós Graduação em Ciências Médicas, Niterói, RJ, Brazil; Universidade Federal Fluminense, Faculdade de Medicina, Disciplina de Doenças Infecciosas e Parasitárias, Niterói, RJ, Brazil.
    This study was conducted to provide information on the genetic diversity of human parvovirus B19 (B19V) circulating in the municipality of Niterói, Rio de Janeiro, Southeast Brazil during 1996-2006, a period with two distinct outbreaks of B19V infection: 1999-2000 and 2004-2005. A total of 27 sera from patients with erythema infectiosum and five sera from HIV-infected patients that tested positive for B19V DNA during the study period were analyzed. To genotype B19V strains, a semi-nested PCR for partial amplification of the capsid gene was performed and sequence analysis revealed that 31 sequences belonged to subgenotype 1a (G1a) of the main genotype 1 and one sequence was characterized as subgenotype 3b (G3b). Read More

    Combining Cell and Gene Therapy in an Effort to Eradicate HIV.
    AIDS Patient Care STDS 2016 Dec;30(12):534-538
    1 Department of Pediatrics, University of Washington , Seattle, Washington.
    More than 30 million people are infected with HIV, and HIV remains the fifth leading cause of disability-adjusted life years worldwide. Antiretroviral therapy (ART) dramatically decreases mortality rate, but there are side effects, long-term toxicities, expenses, stigmas, and inconveniences associated with chronic treatment, and HIV-infected individuals on ART have an increased risk of malignancies, cardiovascular disease, neurologic disease, and shortened life expectancy. Therefore, a cure for HIV remains an important goal. Read More

    Pure red cell aplasia.
    Blood 2016 11;128(21):2504-2509
    Office of the Dean, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.
    Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Read More

    DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain.
    Biochemistry 2016 Nov 17;55(47):6577-6593. Epub 2016 Nov 17.
    Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
    Infection with human parvovirus B19 (B19V) has been associated with a myriad of illnesses, including erythema infectiosum (Fifth disease), hydrops fetalis, arthropathy, hepatitis, and cardiomyopathy, and also possibly the triggering of any number of different autoimmune diseases. B19V NS1 is a multidomain protein that plays a critical role in viral replication, with predicted nuclease, helicase, and gene transactivation activities. Herein, we investigate the biochemical activities of the nuclease domain (residues 2-176) of B19V NS1 (NS1-nuc) in sequence-specific DNA binding of the viral origin of replication sequences, as well as those of promoter sequences, including the viral p6 and the human p21, TNFα, and IL-6 promoters previously identified in NS1-dependent transcriptional transactivation. Read More

    J Biol Chem 2016 Dec 25;291(50):26126-26137. Epub 2016 Oct 25.
    From the MitoCare Center for Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107,
    The relevance of mitochondrial phosphate carrier (PiC), encoded by SLC25A3, in bioenergetics is well accepted. However, little is known about the mechanisms mediating the cellular impairments induced by pathological SLC25A3 variants. To this end, we investigated the pathogenicity of a novel compound heterozygous mutation in SLC25A3 First, each variant was modeled in yeast, revealing that substituting GSSAS for QIP within the fifth matrix loop is incompatible with survival on non-fermentable substrate, whereas the L200W variant is functionally neutral. Read More

    Not the Usual Viral Suspects: Parvovirus B19, West Nile Virus, and Human T-Cell Lymphotrophic Virus Infections After Kidney Transplantation.
    Semin Nephrol 2016 Sep;36(5):428-434
    Division of Infectious Diseases and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN. Electronic address:
    Kidney transplant recipients are at increased risk of developing clinical disease due to uncommon opportunistic viral pathogens. Refractory anemia is classically associated with parvovirus B19 infection. West Nile virus has the propensity to cause fever and neurologic symptoms, while spastic paresis and lymphoma can be triggered by human T cell lymphotrophic virus. Read More

    The Economic Burden of Road Traffic Injuries on Households in South Asia.
    PLoS One 2016 21;11(10):e0164362. Epub 2016 Oct 21.
    Nossal Institute for Global Health, The University of Melbourne, 161 Barry Street, 4th Floor, Carlton, VIC 3053, Australia.
    Globally, road traffic injuries accounted for about 1.36 million deaths in 2015 and are projected to become the fourth leading cause of disability-adjusted life years (DALYs) lost by 2030. One-fifth of these deaths occurred in South Asia where road traffic injuries are projected to increase by 144% by 2020. Read More

    1 OF 33