Search Our Scientific Publications & Authors

Front Nutr 2022 9;9:868273. Epub 2022 Jun 9.

Dietetic and Clinical Nutrition Unit, Paediatric Hospital Regina Margherita, University of Turi, Turin, Italy.

Background And Aims: Chronic intestinal failure (CIF) therapy changed significantly in recent decades, and both survival and complication rates improved over time. International guidelines claim that early referral of long-term home parenteral nutrition (HPN) patients to an expert center with specific standards of care may positively affect long-term outcomes. Herein, we retrospectively analyse the long-term outcomes of a cohort of pediatric patients with CIF followed-up since our Pediatric Intestinal Failure Unit foundation, in 1989. Read More

Rev Chilena Infectol 2022 02;39(1):95-99

Hospital Universitario Miguel Servet, Zaragoza, España.

Parvovirus B19 is the cause of a variety of exanthematous diseases during childhood and adolescence, such as erythema infectiosum and papular purpuric gloves and socks syndrome. This is an unusual, benign and acute acrodermatitis. Aphtous stomatitis, fever and other systemic symptoms can be associated with the eruption of the purpuric rash. Read More

Curr Med Sci 2022 Jun 21. Epub 2022 Jun 21.

Department of Pulmonology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.

Objective: To determine the clinical characteristics and prognosis of primary tracheobronchial tumors (PTTs) in children, and to explore the most common tumor identification methods.

Methods: The medical records of children with PTTs who were hospitalized at the Children's Hospital of Chongqing Medical University from January 1995 to January 2020 were reviewed retrospectively. The clinical features, imaging, treatments, and outcomes of these patients were statistically analyzed. Read More

Dis Markers 2022 6;2022:5286820. Epub 2022 Jun 6.

Department of General Surgery, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.

Background: CYP26A1 has been reported in multiple cancers. However, the role of CYP26A1 in pancreatic cancer (PC) has not been explored.

Method: The public data used for this study was obtained from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Cancer Cell Line Encyclopedia (CCLE) cell lines. Read More

Front Endocrinol (Lausanne) 2022 27;13:895458. Epub 2022 May 27.

Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Aims: This study aimed to assess the impact of different antidiabetic agents on individuals with diabetes and COVID-19.

Methods: We searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to October 31, 2021 and included seven antidiabetic agents. The data were pooled traditional pairwise meta-analysis and Bayesian network meta-analysis. Read More

Front Microbiol 2022 24;13:914181. Epub 2022 May 24.

Department of Virology, University of Helsinki, Helsinki, Finland.

Parvoviruses are single-stranded DNA viruses, infecting many animals from insects to humans. Human parvovirus B19 (B19V) causes erythema infectiosum, arthropathy, anemia, and fetal death, and human bocavirus (HBoV) 1 causes respiratory tract infections, while HBoV2-4 are enteric. Parvoviral genomes can persist in diverse non-permissive tissues after acute infection, but the host-cell tropism and the impact of their tissue persistence are poorly studied. Read More

Am J Cardiol 2022 Jul 31;175:127-130. Epub 2022 May 31.

Sports Cardiology, Baker Heart and Diabetes Institute, Melbourne, Australia; Cardiology Department, Alfred Hospital, Melbourne, Australia; Cardiology Department, St. Vincent's Hospital, Melbourne, Australia.

Coronary artery anomalies (CAAs) have been previously implicated as a major cause of young sudden cardiac death (SCD), particularly in exercise-related SCD, with a prevalence of up to 33%. A state-wide prospective out-of-hospital cardiac arrest registry identified all patients aged 1 to 50 years who experienced an SCD and underwent autopsy from April 2019 to April 2021. Rates of normal anatomy, normal variants, and CAAs were identified, and circumstances and causes of death for patients with CAAs examined. Read More

BMC Pediatr 2022 Jun 3;22(1):327. Epub 2022 Jun 3.

Department of Surgery, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Background: Despite the relative prevalence of small bowel and proximal colon perforation in the neonatal period, recto-sigmoid perforation is extremely rare. Full-term neonates experience intestinal perforation less frequently than premature infants. Here we report a neonate with sigmoid perforation and simultaneous Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. Read More

J Med Cases 2022 May 23;13(5):229-234. Epub 2022 Apr 23.

Department of Pediatrics, Kitami Red Cross Hospital, Kitami, Hokkaido 090-8666, Japan.

Human parvovirus B19 (B19) is a single-stranded DNA virus that targets erythroid progenitor cells in the bone marrow. B19 causes erythema infectiosum in children, transient aplastic anemia, pure red cell aplasia, hydrops fetalis, and contributes to other illnesses. An association between B19 infection and hypocomplementemia and rheumatoid arthritis has been reported, but the underlying mechanisms remain unclear. Read More

Pathogens 2022 Apr 21;11(5). Epub 2022 Apr 21.

Clinical and Applied Virology Group, Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg.

Primate erythroparvovirus 1, commonly referred to as Parvovirus B19 (B19V), is a DNA virus that normally results in a mild childhood infection called "erythema infectiosum". Besides respiratory spread, B19V can also be transmitted through transfusions, which may result in persistent anemia in immunodeficient hosts. Dialysis patients often face acute or chronic anemia after infection with B19V. Read More

Mediterr J Hematol Infect Dis 2022 1;14(1):e2022044. Epub 2022 May 1.

Department of Surgery, Faculty of Medicine, Thammasat University. 95 M 8 Phahonyothin Rd, Khlong nueng, Khlong Luang District, Pathum Thani, 12120, Thailand.

Background: Few studies had focused on the epidemiological and clinical characteristics of pediatric COVID-19 (SARS-CoV-2) during Delta and pre-Delta eras in Asia, despite it being a pandemic.

Objective: To study the epidemiological and clinical characteristics of three waves of pediatric COVID-19 infections in a tertiary-care setting in Thailand.

Methods: This retrospective study reviewed all PCR-confirmed pediatric (0-18 years of age) COVID-19 infections between January 13, 2020, and October 31, 2021, in a tertiary care system in Thailand. Read More

Pharmacology 2022 May 24:1-12. Epub 2022 May 24.

Department of Anesthesiology, The Fifth People's Hospital of Jinan, Jinan, China.

Introduction: Sufentanil is used with ropivacaine in labor pain management but it can have respiratory depression. Dexmedetomidine is effective to maintain hemodynamic stability in parturient women and allow awake intubation. However, dexmedetomidine is suggested only in patients with major cardiovascular disease that mandates stable hemodynamics (Reference ID: 3987541-USFDA). Read More

Pediatr Int 2022 Jan;64(1):e15145

Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Owing to the lack of data, we aimed to determine the etiology and outcome of acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) in children in Southeast Asia.

Methods: This retrospective study was conducted at a university hospital in Bangkok, Thailand. We included patients aged <18 years who were diagnosed with pancreatitis from 2000 to 2021. Read More

Rinsho Shinkeigaku 2022 May 26;62(5):363-368. Epub 2022 Apr 26.

Department of Neurology, Hyogo Prefectural Awaji Medical Center.

We have reported a case of a 44-year-old woman with anti-signal recognition particle (SRP) antibody-positive immune-mediated necrotizing myopathy triggered by human parvovirus B19 (PVB19) infection. She was admitted to the hospital because of lower leg edema and muscle weakness after erythema infectiosum. Magnetic resonance imaging of the lower extremities revealed high signals in the proximal muscles and subcutaneous edema on STIR. Read More

Epidemiol Infect 2022 Apr 27:1-19. Epub 2022 Apr 27.

Department of Infectious Disease, Wuxi Children's Hospital, Wuxi, China.

JCI Insight 2022 Jun 8;7(11). Epub 2022 Jun 8.

Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Hangzhou, China.

Inherited kidney diseases are the fifth most common cause of end-stage renal disease (ESRD). Mitochondrial dysfunction plays a vital role in the progression of inherited kidney diseases, while mitochondrial-transfer RNA (mt-tRNA) variants and their pathogenic contributions to kidney disease remain largely unclear. In this study, we identified the pathogenic mt-tRNAPhe 616T>C mutation in 3 families and documented that m. Read More

Front Genet 2022 8;13:848879. Epub 2022 Apr 8.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Rubinstein-Taybi Syndrome (RSTS) is a rare congenital disease with distinctive facial features, broadening of the thumbs and halluces, and developmental delay. RSTS is caused by genetic alterations in and the homologous genes. In this study, we established a genetic diagnostic protocol by integrating multiplex ligation-dependent probe amplification (MLPA) and whole-exome sequencing (WES). Read More

Oncologist 2022 Apr 15. Epub 2022 Apr 15.

Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.

Background: Young adults (YA) diagnosed with rectal cancer are disproportionately impacted by the gonadotoxic effects of treatment and potential subsequent infertility.

Objective: The purpose of this study was to characterize the prevalence of fertility preservation measures used, reasons why such measures were not used, and correlates of discussion between providers and YA rectal cancer survivors.

Design: An online, cross-sectional survey was administered on the Facebook page of a national colorectal cancer (CRC) advocacy organization. Read More

Dis Markers 2022 4;2022:2159660. Epub 2022 Apr 4.

Department of Pediatrics, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, China.

Objective: To study and explore the effect of double-heart nursing combined with seaweed polysaccharide on improving the self-efficacy and quality of life of patients with coronary heart disease and diabetes.

Methods: Eligible 214 patients with coronary heart disease and diabetes who were diagnosed and treated in our hospital between year 2017 and 2020 were randomized at a ratio of 1 : 1 to either control group (seaweed polysaccharide) or observation group (double-heart nursing combined with seaweed polysaccharide). The self-efficacy and quality of life of the two groups of patients after treatment were compared. Read More

Pediatrics 2022 05;149(5)

Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

Objectives: National guidelines call for annual testing for certain sexually transmitted infections (STIs) among specific adolescent populations, yet we have limited population-based data on STI testing prevalence among adolescents. With inclusion of a new item in the 2019 national Youth Risk Behavior Survey, we provide generalizable estimates of annual STI testing among sexually active high school students.

Methods: We report weighted prevalence estimates of STI testing (other than HIV) in the past 12 months among sexually active students (n = 2501) and bivariate associations between testing and demographic characteristics (sex, age, race and ethnicity, sexual identity, and sex of sexual contact). Read More

Kidney Med 2022 Mar 21;4(3):100415. Epub 2022 Jan 21.

Center for Translational Research, The Children's Research Institute, Children's National Health System, Washington, DC.

Rationale & Objective: Little is known about symptoms and disease impacts in adolescents with autosomal dominant polycystic kidney disease (ADPKD). The objective of the study was to explore these issues from the adolescent patient's perspective.

Study Design: Observational, qualitative study. Read More

Clin Ter 2022 Apr;173(2):104-106

Near East University Hospital Radiology Department, Nicosia, Cyprus.

Abstract: Parvovirus B19 infection can be associated with a wide spec-trum of clinical manifestations that mainly depends on the clinical background of the patient. Infection causes severe aplastic effects on bone marrow in immunosuppressive patients. Our patient was using Azathioprine for Crohn Disease when she admitted with malaise and fatigue laboratory tests revealed pancytopenia due to Parvovirus B19 infection . Read More

Curr Pediatr Rev 2022 Apr 1. Epub 2022 Apr 1.

Microbiology, Balram Ji Omar, All India Institute of Medical Science, Rishikesh, Uttarakhand, India.

The fifth malaria parasite causing human malaria- Plasmodium knowlesi (Pk), is not a newly emergent species but was an undiagnosed species before availability of molecular methods as diagnostic tool and was often confused with morphologically similar human malaria parasite P. malariae or P. falciparum. Read More

ERJ Open Res 2022 Jan 14;8(1). Epub 2022 Mar 14.

Dept of Paediatrics and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.

Objective: Exercise-induced laryngeal obstruction is an important cause of exertional dyspnoea. The diagnosis rests on visual judgement of relative changes of the laryngeal inlet during continuous laryngoscopy exercise (CLE) tests, but we lack objective measures that reflect functional consequences. We aimed to investigate repeatability and normal values of translaryngeal airway resistance measured at maximal intensity exercise. Read More

Acta Radiol 2022 Mar 21:2841851221085685. Epub 2022 Mar 21.

Department of Pediatrics, 117872Hebei General Hospital, Shijiazhuang, Hebei, PR China.

Background: Coronary artery distension and aneurysm are complications of Kawasaki disease in children.

Purpose: To develop a Z-score regression model for coronary artery diameter in children that could be used as reference.

Material And Methods: This retrospective analysis included children with normal heart structure between March 2013 and April 2017. Read More

Biomed Res Int 2022 3;2022:9916325. Epub 2022 Mar 3.

Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.

As the most common form of developmental malformation affecting the heart and endothoracic great vessels, congenital heart disease (CHD) confers substantial morbidity and mortality as well as socioeconomic burden on humans globally. Aggregating convincing evidence highlights the genetic origin of CHD, and damaging variations in over 100 genes have been implicated with CHD. Nevertheless, the genetic basis underpinning CHD remains largely elusive. Read More

J Immunol 2022 04 11;208(7):1642-1651. Epub 2022 Mar 11.

Center for Infection and Immunity, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China.

The immunoregulation of platelets and platelet-monocyte aggregates (PMAs) is increasingly recognized, but it roles in tuberculosis (TB) remain to be elucidated. In this study, we found that CD14CD41 PMAs were increased in peripheral blood of patients with active TB. CD14CD41 PMAs highly expressed triggering receptors expressed on myeloid cells (TREMs)-like transcript-1 (TLT-1), P-selectin (CD62P), and CD40L. Read More

BMC Infect Dis 2022 Mar 7;22(1):231. Epub 2022 Mar 7.

Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.

Background: Infection with human parvovirus B19 (PB19) is very common in pediatric patients. Symptoms and signs depend on the infected patient's immune and hematopoietic status and can range from an asymptomatic condition to life-threatening disease.

Case Presentation: A 69-year-old man received elective mitral valvular replacement and tricuspid valvuloplasty under cardiopulmonary bypass and suffered acute respiratory distress syndrome on postoperative day 8. Read More

Prague Med Rep 2022 ;123(1):48-55

2nd Neonatal Department and Neonatal Intensive Care Unit, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital of Thessaloniki, Thessaloniki, Greece.

Parvovirus B19 infection in pregnancy may have a poor outcome for the fetus. Ocular anomalies, brain damage with hydrocephalus and central nervous system (CNS) scarring, cleft lip and hypospadias, as well myocarditis and congenital heart disease have been reported. We present a case of a preterm female neonate born with ascites, hydrothorax and congenital diaphragmatic eventration (CDE), with a prenatal diagnosis of congenital diaphragmatic hernia (CDH). Read More

Clin Transl Med 2022 02;12(2):e746

The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics; Tianjin Key Laboratory of Cellular Homeostasis and Human Diseases; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, China.

Background: Aging-associated osteoporosis is frequently seen in the elderly in clinic, but efficient managements are limited because of unclear nosogenesis. The current study aims to investigate the role of melatonin on senescent bone marrow stromal cells (BMSCs) and the underlying regulating mechanism.

Methods: Melatonin levels were tested by ELISA. Read More