1,848 results match your criteria Pediatrics Fifth Disease or Erythema Infectiosum


Prevalence of Human Parvovirus B19 in Neurological Patients: Findings from Region of Western Saudi Arabia.

Curr Health Sci J 2020 Jan-Mar;46(1):16-22. Epub 2020 Mar 31.

Department of Neurology, Al Noor Specialists Hospital, Makkah, Saudi Arabia.

Human parvovirus (B19) infection causes Erythema infectiosum in persons with other hematological disorders like aplastic anemia and complications such as hydrops fetalis, spontaneous abortions. This study aimed to determine the prevalence of IgG and IgM antibodies in B19 infected neurological patients and to assess possible transmission related risk factors. This cross-sectional descriptive study comprised 140 neurological patients. Read More

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http://dx.doi.org/10.12865/CHSJ.46.01.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323727PMC

Child-Adult Transition in Sarcoidosis: A Series of 52 Patients.

J Clin Med 2020 Jul 3;9(7). Epub 2020 Jul 3.

AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Armand Trousseau Hospital, 75012 Paris, France.

(1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. Read More

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http://dx.doi.org/10.3390/jcm9072097DOI Listing

Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study.

Front Endocrinol (Lausanne) 2020 16;11:310. Epub 2020 Jun 16.

Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Different metabolic phenotypes of obesity are related to cardiometabolic risk factors in children and adolescents. Vitamin D, as one important factor, could be related to different subgroups of metabolic obesity and might affect metabolic disorders. The purpose of this study was to evaluate the relationship between serum 25-hydroxyvitamin D concentration and subsets of metabolic phenotypes of obesity in children and adolescents. Read More

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http://dx.doi.org/10.3389/fendo.2020.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308554PMC

In Vitro Lymphocyte Functions in Undernourished Children With Sickle Cell Anemia.

Ochsner J 2020 ;20(2):151-160

Department of Pediatrics, Division of Hematology/Oncology, Louisiana State University Health Sciences Center, New Orleans, LA.

Children with sickle cell disease (SCD) often suffer from growth deficits and impaired immunity. However, the association between mild to moderate malnutrition and in vitro lymphocyte function has not been well studied. The goal of this study was to investigate the effects of undernutrition on lymphocyte functions in children with SCD. Read More

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http://dx.doi.org/10.31486/toj.19.0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310185PMC
January 2020

Advanced imaging tools for childhood tuberculosis: potential applications and research needs.

Lancet Infect Dis 2020 Jun 23. Epub 2020 Jun 23.

Tuberculosis Clinic, Pima County Health Department, Tucson, AZ, USA; Division of Infectious Diseases, University of Arizona College of Medicine, Tucson, AZ, USA.

Tuberculosis is the leading cause of death globally that is due to a single pathogen, and up to a fifth of patients with tuberculosis in high-incidence countries are children younger than 16 years. Unfortunately, the diagnosis of childhood tuberculosis is challenging because the disease is often paucibacillary and it is difficult to obtain suitable specimens, causing poor sensitivity of currently available pathogen-based tests. Chest radiography is important for diagnostic evaluations because it detects abnormalities consistent with childhood tuberculosis, but several limitations exist in the interpretation of such results. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30177-8DOI Listing

Implementation Patterns of Two Evidence-Based Psychotherapies in Veterans Affairs Residential Posttraumatic Stress Disorder Programs: A Five-Point Longitudinal National Investigation.

J Trauma Stress 2020 Jun 25. Epub 2020 Jun 25.

Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

The present study examined the patterns of adoption of two evidence-based psychotherapies (EBPs)-prolonged exposure (PE) and cognitive processing therapy (CPT)-in U.S. Department of Veterans Affairs (VA) residential posttraumatic stress disorder (PTSD) treatment programs. Read More

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http://dx.doi.org/10.1002/jts.22557DOI Listing

Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of Cellular Autophagy.

iScience 2020 Jun 10;23(7):101256. Epub 2020 Jun 10.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, MUH 628 NW, Pittsburgh, PA 15213, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

Respiratory syncytial virus (RSV) infection can cause severe bronchiolitis in infants requiring hospitalization, whereas the elderly and immunocompromised are prone to RSV-induced pneumonia. RSV primarily infects lung epithelial cells. Given that no vaccine against RSV is currently available, we tested the ability of the epithelial-barrier protective cytokine interleukin-22 (IL-22) to control RSV production. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317237PMC

Proceedings of the 4 BEAT-PCD Conference and 5 PCD Training School.

BMC Proc 2020 19;14(Suppl 8). Epub 2020 Jun 19.

Primary Ciliary Dyskinesia Centre, Royal Brompton Hospital, Sydney Street, London, UK.

Primary ciliary dyskinesia (PCD) is an inherited ciliopathy leading to chronic suppurative lung disease, chronic rhinosinusitis, middle ear disease, sub-fertility and abnormalities. As PCD is rare, it is important that scientists and clinicians foster international collaborations to share expertise in order to provide the best possible diagnostic and management strategies. 'Better Experimental Approaches to Treat Primary Ciliary Dyskinesia' (BEAT-PCD) is a multidisciplinary network funded by EU COST Action (BM1407) to coordinate innovative basic science and clinical research from across the world to drive advances in the field. Read More

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http://dx.doi.org/10.1186/s12919-020-00191-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304082PMC

[Advances in molecular biology research on human parvovirus B19].

Sheng Wu Gong Cheng Xue Bao 2020 May;36(5):879-890

College of Medical, Hubei University of Arts and Science, Xiangyang 441053, Hubei, China.

Human parvovirus B19 (B19 virus) is one of the two parvoviruses that cause human diseases. As an important pathogen to humans, it causes infectious erythema in children, acute aplastic anemia, fetal edema and death. In this review, we focus on the recent advances in the molecular virology of B19V, such as viral genotypes, viral receptor, genomic features and viral replication, viral transcription and post-transcription regulation, viral nonstructural and structural protein features and functions, viral diagnosis and antiviral agents, to provide reference for further study of B19 pathogenesis mechanisms, treatment and diagnostic strategies. Read More

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http://dx.doi.org/10.13345/j.cjb.190380DOI Listing

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study.

Lancet 2020 Jun 11. Epub 2020 Jun 11.

Division of Primary Care, Geneva University Hospitals, Geneva, Switzerland; Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Background: Assessing the burden of COVID-19 on the basis of medically attended case numbers is suboptimal given its reliance on testing strategy, changing case definitions, and disease presentation. Population-based serosurveys measuring anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies provide one method for estimating infection rates and monitoring the progression of the epidemic. Here, we estimate weekly seroprevalence of anti-SARS-CoV-2 antibodies in the population of Geneva, Switzerland, during the epidemic. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)31304-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289564PMC

Healthcare-Associated Transmission of Parvovirus B19 Arthropathy.

Bull Hosp Jt Dis (2013) 2020 Jun;78(2):140-143

Human parvovirus B19 (B19V) is well known for its infectivity. However, the risk for communicability to previously unexposed healthcare professionals is controversial. We report here a small outbreak of B19V infection among physicians and family members in an adult rheumatology practice that occurred after providing care for a patient with B19V arthropathy. Read More

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Clinical Manifestation of Juvenile and Pediatric HD Patients: A Retrospective Case Series.

Brain Sci 2020 Jun 3;10(6). Epub 2020 Jun 3.

Department of Neurology, Huntington Centre North Rhine-Westphalia, St. Josef-Hospital Bochum, Ruhr-University Bochum, 44791 Bochum, Germany.

Background: Studies on the clinical manifestation and course of disease in children suffering from Huntington's disease (HD) are rare. Case reports of juvenile HD (onset ≤ 20 years) describe heterogeneous motoric and non-motoric symptoms, often accompanied with a delay in diagnosis. We aimed to describe this rare group of patients, especially with regard to socio-medical aspects and individual or common treatment strategies. Read More

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http://dx.doi.org/10.3390/brainsci10060340DOI Listing

Effects of gut microbiome and environment on the development of eczema in Chinese infants.

Medicine (Baltimore) 2020 May;99(21):e20327

The Nethersole School of Nursing.

Background: Eczema is a relapsing and persistent inflammatory skin disease affecting about one-fifth of children worldwide. As in other developed countries, the prevalence of this chronic disease in Hong Kong is approximately 30%. Moreover, the number of local cases reported has been on a rising trend since 1995. Read More

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http://dx.doi.org/10.1097/MD.0000000000020327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250058PMC

Reverse-Transcription Recombinase-Aided Amplification Assay for Rapid Detection of the 2019 Novel Coronavirus (SARS-CoV-2).

Anal Chem 2020 Jul 10. Epub 2020 Jul 10.

Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, P. R. China.

A novel coronavirus (SARS-CoV-2) was recently identified in patients with acute respiratory disease and spread quickly worldwide. A specific and rapid diagnostic method is important for early identification. The reverse-transcription recombinase-aided amplification (RT-RAA) assay is a rapid detection method for several pathogens. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c01032DOI Listing

Kawasaki disease presented with status epilepticus and diffusion MRI abnormalities in the subcortical white matter.

Turk J Pediatr 2020 ;62(2):315-319

Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

Background: Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and young children. Encephalitis/encephalopathy is an extremely rare complication of KD.

Case: A previously healthy 8-month-old Japanese boy had a prolonged seizure after febrile illness for one day. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.020DOI Listing
January 2020

COVID-19: The first documented coronavirus pandemic in history.

Biomed J 2020 May 5. Epub 2020 May 5.

The Research Center for Emerging Viral Infection, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Clinical Virology Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Electronic address:

The novel human coronavirus disease COVID-19 has become the fifth documented pandemic since the 1918 flu pandemic. COVID-19 was first reported in Wuhan, China, and subsequently spread worldwide. The coronavirus was officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses based on phylogenetic analysis. Read More

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http://dx.doi.org/10.1016/j.bj.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199674PMC

Clinical profile and predictors of mortality among the referred neonates at a tertiary care centre in north India: a prospective observational study.

Trop Doct 2020 May 7:49475520921675. Epub 2020 May 7.

Professor, Department of Pediatrics, PGIMS, Rohtak, Haryana, India.

The National Family Health Survey (NFHS-4) shows encouraging improvement in infant and under-five mortality rates in India. However, the neonatal mortality rate (NMR) still remains high as India contributes to about one-fifth of global deaths. This prospective study was conducted from 15 January to 30 April 2016 to examine the clinical profile and predictors of mortality among referred neonates at our centre. Read More

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http://dx.doi.org/10.1177/0049475520921675DOI Listing

Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project.

Eur J Nutr 2020 May 6. Epub 2020 May 6.

Division of Metabolic and Nutritional Medicine, Department of Paediatrics, Dr. von Hauner Children's Hospital, LMU-Ludwig-Maximilians-Universität Munich, Lindwurmstr. 4, 80337, Munich, Germany.

Purpose: We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood.

Methods: Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Read More

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http://dx.doi.org/10.1007/s00394-020-02229-wDOI Listing

Uncertainty of Prenatally Diagnosed Congenital Heart Disease: A Qualitative Study.

JAMA Netw Open 2020 May 1;3(5):e204082. Epub 2020 May 1.

Division of General Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Parents who receive a prenatal diagnosis of congenital heart disease may experience more short- and long-term stress than those who receive a postnatal diagnosis. To identify potential interventions to ameliorate that stress, the longitudinal emotional experience of parents must first be understood.

Objective: To better understand parents' accounts of their own prenatal experience, particularly aspects they found to be stressful or challenging, and to identify strategies to improve support. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.4082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201310PMC

Association of sleep duration and snack consumption in children and adolescents: The CASPIAN-V study.

Food Sci Nutr 2020 Apr 19;8(4):1888-1897. Epub 2020 Feb 19.

Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Isfahan Iran.

Objectives: The relationship between sleep deprivation and the risk of overweight and obesity is somewhat known in children and adolescents. This study aimed to investigate the relationship between sleep duration and eating snacks in a national sample of children and adolescents aged 6-18 years old.

Methods: This cross-sectional study was carried out on the data of the fifth survey of the national school-based surveillance system entitled the "Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable Disease" (CASPIAN-V) study. Read More

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http://dx.doi.org/10.1002/fsn3.1471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174214PMC

Long Non-Coding RNA (lncRNA) CRNDE Regulated Lipopolysaccharides (LPS)-Induced MRC-5 Inflammation Injury Through Targeting MiR-141.

Med Sci Monit 2020 Apr 22;26:e920928. Epub 2020 Apr 22.

Department of Thoracic Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, China (mainland).

BACKGROUND Pneumonia is a common disease with high morbidity and even death. In our country, pneumonia is the leading cause of child death. Therefore, research on the pathogenesis of pneumonia can help improve the treatment of pneumonia. Read More

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http://dx.doi.org/10.12659/MSM.920928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191950PMC

FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).

Front Cell Dev Biol 2020 2;8:223. Epub 2020 Apr 2.

Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.

The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD). Recently, research interest has been raised in the immunomodulatory function of FGF2 in asthma and COPD, through its involvement in not only the regulation of inflammatory cells but also its participation as a mediator between immune cells and airway structural cells. Read More

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http://dx.doi.org/10.3389/fcell.2020.00223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142218PMC

Autosomal dominant GCH1 mutations causing spastic paraplegia at disease onset.

Parkinsonism Relat Disord 2020 05 1;74:12-15. Epub 2020 Apr 1.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

Background: Autosomal dominant GCH1 mutations are known to cause dopa-responsive dystonia (DRD). In this case series, we confirm a variant phenotype, characterized by predominant spastic paraplegia at disease onset with development of dystonia and/or parkinsonism only decades later.

Methods: Clinical trajectories of four patients from three families with pathogenic variants in GCH1 are described, illustrated by videos of the motor phenotype before and during treatment with levodopa. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.03.019DOI Listing

Tri-ponderal mass index and body mass index in prediction of pediatric metabolic syndrome: the CASPIAN-V study.

Arch Endocrinol Metab 2020 Apr 27;64(2):171-178. Epub 2020 Mar 27.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective Body mass index (BMI) and tri-ponderal mass index (TMI) are anthropometric measures to evaluate body adiposity in the various age groups. The present study aims to compare the predictive value of TMI and BMI for metabolic syndrome (Mets) in children and adolescents of both genders. Subjects and methods A cross-sectional study conducted on 3731 Iranian children and adolescents aged 7-18 years obtained from the fifth survey of 'Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease' (CASPIAN-V) study. Read More

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http://dx.doi.org/10.20945/2359-3997000000206DOI Listing

Treatment change and coronary artery abnormality in incomplete Kawasaki disease.

Pediatr Int 2020 Mar 27. Epub 2020 Mar 27.

Department of Public Health, Jichi Medical University, Tochigi, Japan.

Background: Incomplete Kawasaki disease (iKD) showed a higher incidence of coronary artery abnormalities (CAAs) compared with complete KD (cKD). However, the incidence of CAAs among iKD patients may have changed recently METHODS: We examined KD patients of recent nationwide surveys conducted between 2013 and 2016 and compared with the results of previous survey (2001-2002).

Results: Among 63,270 KD patients, 13,770 patients (22%) were iKD. Read More

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http://dx.doi.org/10.1111/ped.14242DOI Listing

The rash with mucosal ulceration.

Clin Dermatol 2020 Jan - Feb;38(1):35-41. Epub 2019 Oct 25.

Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Brazil. Electronic address:

A rash is a disseminated eruption of cutaneous lesions with great variation in appearance, cause, and severity. When the physician is facing a rash, the history and physical examination of the patient are extremely important for the identification of the disease and its causal agent. There are various causes for a rash, which may be infectious, allergic, or rheumatologic, besides many others. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.019DOI Listing
October 2019

A novel pathogenic variant in MYO18B associating early-onset muscular hypotonia, and characteristic dysmorphic features, delineation of the phenotypic spectrum of MYO18B-related conditions.

Gene 2020 Jun 14;742:144542. Epub 2020 Mar 14.

Institute of Human Genetics, Technical University of Munich, Munich, Germany; Institute of Neurogenomics, Helmholtz Zentrum Munich, Neuherberg, Germany.

Homozygous loss-of-function variants in MYO18B have been associated with congenital myopathy, facial dysmorphism and Klippel-Feil anomaly. So far, only four patients have been reported. Comprehensive description of new cases that help to highlight recurrent features and to further delineate the phenotypic spectrum are still missing. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144542DOI Listing

[Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):269-274

Department of Pediatric Internal Medicine, Xi'an Children's Hospital, Xi'an 710003, China.

To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus (2019-nCoV) infection in children from six provinces (autonomous region) in northern China. A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. The patients were diagnosed between January 25th, 2020 and February 21st, 2020 in 21 hospitals in 17 cities of six provinces (autonomous region) of Shaanxi, Gansu, Ningxia, Hebei, Henan and Shandong. Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20200225-00138DOI Listing

The Validity and Reliability of the Japanese Version of the Cornell Assessment of Pediatric Delirium.

Pediatr Crit Care Med 2020 05;21(5):e267-e273

Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Objectives: To examine validity and reliability of the Japanese version of the Cornell Assessment of Pediatric Delirium.

Design: Prospective double-blinded observational cohort study.

Setting: Eight-bed mixed PICU (post-surgical and internal medicine) from May 2017 to June 2018. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002274DOI Listing

Ultrasound-Responsive Materials for Drug/Gene Delivery.

Front Pharmacol 2019 31;10:1650. Epub 2020 Jan 31.

Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Read More

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http://dx.doi.org/10.3389/fphar.2019.01650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005489PMC
January 2020

Quality of whole genome sequencing from blood versus saliva derived DNA in cardiac patients.

BMC Med Genomics 2020 01 29;13(1):11. Epub 2020 Jan 29.

Genetics and Genome Biology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada.

Background: Whole-genome sequencing (WGS) is becoming an increasingly important tool for detecting genomic variation. Blood derived DNA is the current standard for WGS for research or clinical purposes but may not always be feasible to acquire. The usability of DNA from saliva for WGS is not known. Read More

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http://dx.doi.org/10.1186/s12920-020-0664-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988365PMC
January 2020

[Impact of hypoxic-ischemic injury on brain development in neonatal rats of different sexes].

Zhonghua Er Ke Za Zhi 2020 Jan;58(1):30-34

Department of Pediatrics, Third Affiliated Hospital of Anhui Medical University, First People's Hospital of Hefei City, Hefei 230061, China.

To investigate the impact of hypoxic-ischemic brain injury (HIBI) on brain development in neonatal rats of different sexes. From January 1 to December 31, 2018, 60 7-day-old SD rats were randomly divided into HIBI-F group (20 rats), HIBI-M group (20 rats), and control group (20 rats, 10 females and 10 males). The animal model of HIBI was established with Rice-Vannucci method, with the rats' left common carotid artery double-ligated and severed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2020.01.008DOI Listing
January 2020

IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection.

Cytokine 2020 Mar 3;127:154965. Epub 2020 Jan 3.

Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. Electronic address:

Background: Mechanisms influencing severity of acute lower respiratory infection (ALRI) in children are not established. We aimed to assess the role of inflammatory markers and respiratory viruses in ALRI severity.

Methods: Concentrations of interleukin(IL)-33, soluble suppression of tumorigenicity (sST)2, IL-1ß, tumor necrosis factor α, IL-4, IL-6 and IL- 8 and types of respiratory viruses were evaluated in children at the first and fifth days after hospital admission. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.154965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129023PMC

Laundering CNV data for candidate process prioritization in brain disorders.

Mol Cytogenet 2019 26;12:54. Epub 2019 Dec 26.

Mental Health Research Center, Russia Moscow, 115522.

Background: Prioritization of genomic data has become a useful tool for uncovering the phenotypic effect of genetic variations (e.g. copy number variations or CNV) and disease mechanisms. Read More

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http://dx.doi.org/10.1186/s13039-019-0468-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933640PMC
December 2019

A Meta-Analysis on the Seroprevalence of Parvovirus B19 among Patients with Sickle Cell Disease.

Biomed Res Int 2019 9;2019:2757450. Epub 2019 Dec 9.

Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Background: Parvovirus B19 (B19 V) infection had been reported to be more frequent with serious clinical outcomes in patients with sickle cell disease (SCD) than in the general population. There is a wide variation in data among the existing literature regarding the seroprevalence of B19 V in patients with SCD. These data require further summary and analyses for better accuracy. Read More

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http://dx.doi.org/10.1155/2019/2757450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925911PMC

Equivalent schedules of intradermal fractional dose versus intramuscular full dose of inactivated polio vaccine for prevention of poliomyelitis.

Cochrane Database Syst Rev 2019 12 19;12:CD011780. Epub 2019 Dec 19.

Postgraduate Institute of Medical Education and Research, Department of Pediatrics, Sector 12, Chandigarh, India, 160012.

Background: Poliomyelitis is a debilitating and deadly infection. Despite exponential growth in medical science, there is still no cure for the disease, which is caused by three types of wild polioviruses: types 1, 2, and 3. According to the Global Polio Eradication Initiative (GPEI), wild poliovirus is still in circulation in three countries, and fresh cases have been reported even in the year 2018. Read More

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http://dx.doi.org/10.1002/14651858.CD011780.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923520PMC
December 2019

Assessment of treatment responses in children and adolescents with Ewing sarcoma with metabolic tumor parameters derived from F-FDG-PET/CT and circulating tumor DNA.

Eur J Nucl Med Mol Imaging 2020 Jun 18;47(6):1564-1575. Epub 2019 Dec 18.

Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Purpose: The purpose of this study was to perform a prospective integrated analysis of F-fluorodeoxyglucose (F-FDG)-positron emission tomography (PET)/computed tomography (CT) and circulating tumor DNA (ctDNA) to assess responses to multimodal chemotherapy in children and adolescents suffering from Ewing sarcoma (EwS).

Methods: A total of 20 patients with histologically confirmed EwS underwent multiple F-FDG-PET/CT, performed at the time of each patient's initial diagnosis and after the second and fifth induction chemotherapy block (EWING2008 treatment protocol, NCT00987636). Additional PET examinations were performed as clinically indicated in some patients, e. Read More

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http://dx.doi.org/10.1007/s00259-019-04649-1DOI Listing

The Role of Human Parvovirus B19 in the Pediatric Patients with Pancytopenia?

Clin Lab 2019 Dec;65(12)

Background: Parvoviruses are small DNA viruses causing erythema infectiosum, which is known as the fifth disease. The aim of this study was to investigate the presence of Parvovirus B19 DNA by Real-Time-PCR retrospectively in clinical samples of children diagnosed as acute leukemia and aplastic anemia when investigating the cause of pancytopenia and to investigate its relationship with the clinical manifestations.

Methods: The study samples were collected between March 2014 and March 2018 in Gazi University, Faculty of Medicine, Department of Pediatric Hematology. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190311DOI Listing
December 2019

The Use of Biopsy and "No-Biopsy" Approach for Diagnosing Paediatric Coeliac Disease in the Central European Region.

Gastroenterol Res Pract 2019 15;2019:9370397. Epub 2019 Nov 15.

University Medical Centre Maribor, Department of Paediatrics, Gastroenterology, Hepatology and Nutrition Unit, Maribor, Slovenia.

Objectives: The current European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines introduced the option to diagnose coeliac disease (CD) in children and adolescents without upper endoscopy if the defined criteria are met. The aim of our study was to evaluate how frequently paediatric gastroenterologists in Central Europe used the "no-biopsy" approach and how often the duodenal biopsy could have been omitted.

Methods: Medical records of patients aged < 19 years diagnosed with CD in 2016 from five European countries were analysed, focusing on levels of transglutaminase antibodies (TGA) at the time of diagnosis and on whether the diagnosis was confirmed using duodenal biopsy or "no-biopsy" approach. Read More

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http://dx.doi.org/10.1155/2019/9370397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885281PMC
November 2019

Discriminatory ability of visceral adiposity index as an indicator for modeling cardio-metabolic risk factors in pediatric population: the CASPIAN-V study.

J Cardiovasc Thorac Res 2019 24;11(4):280-286. Epub 2019 Oct 24.

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

The purpose of this study was to obtain the cutoff points of visceral adiposity index (VAI), a new marker of indirect evaluation of visceral fat, to assess its association with metabolic syndrome (MetS) in a population of children and adolescents. This cross sectional study was conducted on children and adolescents aged 7-18 years attended in the fifth phase of a national school-based surveillance survey. The odds ratio (OR) of cardiometabolic risk factors across tertile categories of VAI was determined using the logistic regression models and the valid cut-off values of VAI for predicting MetS was obtained using the receiver operation characteristic (ROC) curve analysis. Read More

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http://dx.doi.org/10.15171/jcvtr.2019.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891043PMC
October 2019

The Challenge of Treatment in Potential Celiac Disease.

Gastroenterol Res Pract 2019 20;2019:8974751. Epub 2019 Oct 20.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

Potential celiac disease (PCD) is defined by the presence of positive serum antibodies, HLA-DQ2/DQ8 haplotypes, and a normal small intestinal mucosa (Marsh grade 0-1). This condition occurs in one-fifth of celiac disease (CD) patients and usually represents a clinical challenge. We reviewed genetic, histologic, and clinical features of this specific condition by performing a systematic search on MEDLINE, Embase, and Scholar database. Read More

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http://dx.doi.org/10.1155/2019/8974751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854910PMC
October 2019

A Novel SLC1A4 Mutation (p.Y191*) Causes Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM) With Seizure Disorder.

Child Neurol Open 2019 8;6:2329048X19880647. Epub 2019 Oct 8.

Department of Paediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.

Spastic tetraplegia, thin corpus callosum, and progressive microcephaly is a recently described very rare autosomal recessive neurodevelopmental disorder. This disease was first described in 2015 in several families from the Ashkenazi Jewish ancestry with a founder mutation in (p.E256K) as the underlying genetic cause. Read More

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http://dx.doi.org/10.1177/2329048X19880647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852354PMC
October 2019

Pulmonary hypertension in paediatrics. A feasible approach to bridge the gap between real world and guidelines.

J Matern Fetal Neonatal Med 2019 11 19:1-211. Epub 2019 Nov 19.

, "Tor Vergata" University of Rome, Rome, Italy.

Pulmonary hypertension (PH) is quite infrequent in paediatric age and its most common aetiologies include idiopathic pulmonary arterial hypertension, PH related to congenital heart diseases, bronchopulmonary dysplasia (chronic lung disease), persistence of pulmonary hypertension of the newborn, and congenital diaphragmatic hernia. The developed for adult patients PH classification shows limitations when applied to paediatric subjects, since the underlying causes are markedly different between the two ages. In 2011, the Pulmonary Vascular Research Institute Panama Task Force outlined the first specific paediatric pulmonary hypertensive vascular disease diagnostic classification, including 10 main categories and 109 subcategories, thus testifying PH complex pathophysiology during newborns/children growth and development. Read More

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http://dx.doi.org/10.1080/14767058.2019.1695770DOI Listing
November 2019

Return of Menses in Previously Overweight Patients with Eating Disorders.

J Pediatr Adolesc Gynecol 2020 Apr 9;33(2):133-138. Epub 2019 Nov 9.

Department of General Pediatrics and Adolescent Medicine, Cleveland Clinic Children's Hospital, Cleveland, Ohio.

Study Objective: Adolescents with eating disorders and a history of overweight present with higher weights, longer duration of disease, but equally severe symptomatology compared with previously normal weight patients. To better delineate treatment goals for this understudied population, we compared weight at menses resumption with premorbid maximum weight among previously overweight and normal weight patients.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.11.002DOI Listing

Parvovirus B19 Infection With Positive Rumpel-Leede Sign.

Authors:
Junki Mizumoto

Am J Med 2020 05 9;133(5):e195-e196. Epub 2019 Nov 9.

Ehime Prefectural Central Hospital, Ehime, Japan; Ehime Seikyou Hospital, Ehime, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.10.021DOI Listing

Resveratrol treatment improves the altered metabolism and related dysbiosis of gut programed by prenatal high-fat diet and postnatal high-fat diet exposure.

J Nutr Biochem 2020 01 27;75:108260. Epub 2019 Oct 27.

Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

A maternal high-fat (HF) diet sensitizes offspring to the adverse effects of postnatal HF intake and can lead to metabolic dysregulation. Resveratrol, a natural polyphenolic compound found in grapes and red wine, could help to relieve metabolic syndrome dysregulation. Since the gut microbiota is known to be closely related to metabolic homeostasis, this study aimed to investigate the impact of a combination of maternal and postweaning HF diets on the gut microbiota and whether resveratrol could relieve the gut dysbiosis associated with metabolic dysregulation. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.108260DOI Listing
January 2020
3.794 Impact Factor

Therapeutic plasma exchange for neuromyelitis optica spectrum disorder: A multicenter retrospective study by the ASFA neurologic diseases subcommittee.

J Clin Apher 2020 Jan 9;35(1):25-32. Epub 2019 Nov 9.

Department of Coagulation, Quest Diagnostics Nichols Institute, Chantilly, Virginia.

Importance: Neuromyelitis optica/neuromyelitis optica spectrum disorder patients' response to therapeutic plasma exchange (TPE) is currently incompletely characterized.

Objective: Our study aims to understand the clinical status improvement of neuromyelitis optica/neuromyelitis optica spectrum disorder patients treated with TPE.

Design, Setting, And Participants: This is a multicenter retrospective study conducted between 1 January 2003 and 31 July 2017 at 13 US hospitals performing apheresis procedures. Read More

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http://dx.doi.org/10.1002/jca.21754DOI Listing
January 2020
1.579 Impact Factor

The Impact of Surgical Intervention on Neurodevelopmental Outcomes in Very Low Birth Weight Infants: a Nationwide Cohort Study in Korea.

J Korean Med Sci 2019 Nov 11;34(43):e271. Epub 2019 Nov 11.

Department of Pediatrics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.

Background: To investigate the incidence of surgical intervention in very low birth weight (VLBW) infants and the impact of surgery on neurodevelopmental outcomes at corrected ages (CAs) of 18-24 months, using data from the Korean Neonatal Network (KNN).

Methods: Data from 7,885 VLBW infants who were born and registered with the KNN between 2013 to 2016 were analyzed in this study. The incidences of various surgical interventions and related morbidities were analyzed. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838604PMC
November 2019
1 Read

Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.

Lancet Infect Dis 2019 12 5;19(12):e405-e421. Epub 2019 Nov 5.

Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Mucormycosis is a difficult to diagnose rare disease with high morbidity and mortality. Diagnosis is often delayed, and disease tends to progress rapidly. Urgent surgical and medical intervention is lifesaving. Read More

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http://dx.doi.org/10.1016/S1473-3099(19)30312-3DOI Listing
December 2019
6 Reads
22.433 Impact Factor