12,515 results match your criteria Pediatrics Fever


Clinical Manifestations of Children with COVID-19: a Systematic Review.

Pediatr Pulmonol 2020 Jun 3. Epub 2020 Jun 3.

Pediatric Intensive Care Unit, Department of Pediatrics, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Background: The coronavirus disease 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. The aim of this study was to describe the clinical, laboratorial and radiological characteristics of children with COVID-19. Read More

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http://dx.doi.org/10.1002/ppul.24885DOI Listing

Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York.

JAMA Pediatr 2020 Jun 3:e202430. Epub 2020 Jun 3.

Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.

Importance: Descriptions of the coronavirus disease 2019 (COVID-19) experience in pediatrics will help inform clinical practices and infection prevention and control for pediatric facilities.

Objective: To describe the epidemiology, clinical, and laboratory features of patients with COVID-19 hospitalized at a children's hospital and to compare these parameters between patients hospitalized with and without severe disease.

Design, Setting, And Participants: This retrospective review of electronic medical records from a tertiary care academically affiliated children's hospital in New York City, New York, included hospitalized children and adolescents (≤21 years) who were tested based on suspicion for COVID-19 between March 1 to April 15, 2020, and had positive results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

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http://dx.doi.org/10.1001/jamapediatrics.2020.2430DOI Listing

Disseminated Cat Scratch Disease in Pediatric Patients in Hawai'i.

Hawaii J Health Soc Welf 2020 May;79(5 Suppl 1):64-70

Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI.

Cat scratch disease is known to be a generally benign, self-resolving illness associated with non-specific symptoms, including lymphadenopathy, fever, fatigue, anorexia, and headaches. However, it can also cause disseminated disease with a wide range of manifestations, including liver and spleen microabscesses, osteomyelitis, encephalitis, and uveitis. Eighteen pediatric cases of disseminated cat scratch disease at a single center in Hawai'i are described. Read More

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Need for strict clinical management of patients with carnitine palmitoyltransferase II deficiency: Experience with two cases detected by expanded newborn screening.

Mol Genet Metab Rep 2020 Sep 27;24:100611. Epub 2020 May 27.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

In Japan, carnitine palmitoyltransferase II (CPTII) deficiency has been included as one of the primary target diseases in the expanded newborn mass screening program since 2018. However, many cases of the severe infantile hepatocardiomuscular form of CPTII deficiency showed severe neurodevelopmental delay or sudden death, which indicated that management of CPTII deficiency in the acute phase remains to be studied in detail. Herein, we discuss two cases diagnosed by newborn mass screening. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2020.100611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260588PMC
September 2020

Pulmonary Hemosiderosis in a Child With Systemic Lupus Erythematosus: A Rare Presentation.

Cureus 2020 Apr 29;12(4):e7890. Epub 2020 Apr 29.

Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.

Pulmonary hemorrhage is an uncommon manifestation in children and is often associated with systemic lupus erythematosus. We report a case of an adolescent girl who presented to our hospital with recurrent episodes of fever, cough, and breathlessness. Later on, she was diagnosed with pulmonary hemosiderosis as a manifestation of systemic lupus erythematosus. Read More

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http://dx.doi.org/10.7759/cureus.7890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255548PMC

Empiric Treatment for Suspected Malaria in the United States: A Case Report.

Cureus 2020 Apr 29;12(4):e7885. Epub 2020 Apr 29.

Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, USA.

Malaria in the United States is rare and most commonly presents among returning travelers from endemic areas. Diagnosis is classically dependent on a positive blood smear or polymerase chain reaction (PCR) test. The objective of this case report is to highlight a case of suspected malaria in a high-risk individual with negative diagnostic testing where a trial of empiric treatment was initiated based on clinical presentation after a thorough discussion of risks and benefits. Read More

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http://dx.doi.org/10.7759/cureus.7885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255543PMC

The clinical characteristics and risk factors for necrotizing pneumonia caused by Mycoplasma pneumoniae in children.

BMC Infect Dis 2020 Jun 1;20(1):391. Epub 2020 Jun 1.

Department of Pulmonology, Capital Institute of Pediatrics-Peking University Teaching Hospital, Beijing, China.

Background: The incidence of necrotizing pneumonia (NP) caused by Mycoplasma pneumoniae (MP) is increasing. We analyzed the clinical characteristics and the risk factors for NP caused by MP.

Methods: A retrospective observational study was conducted in 37 patients with NP caused by MP (NP group) and 74 patients diagnosed with lobar M. Read More

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http://dx.doi.org/10.1186/s12879-020-05110-7DOI Listing

Epidemiological and clinical features of 200 hospitalized patients with corona virus disease 2019 outside Wuhan, China: A descriptive study.

J Clin Virol 2020 May 26;129:104475. Epub 2020 May 26.

Department of Emergency and Critical Care Medicine, The First College of Clinical Medical Science, Three Gorges University/Yichang Central People's Hospital, Yichang, Hubei Province, 443003, China. Electronic address:

Background: The recent outbreak of coronavirus disease 2019 (COVID-19) has spread worldwide, with especially severe epidemics occurring in cities across China.

Objectives: To report the epidemiological and clinical futures of the 200 patients infected with COVID-19 in Yichang, Hubei Province, China.

Study Design: 200 patients confirmed with COVID-19 in a designated hospital in Yichang from Jan 30 to Feb 8, 2020 were investigated retrospectively. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104475DOI Listing

Case 4: Fever, Rash, and Pneumonia in a 6-year-old Boy.

Pediatr Rev 2020 Jun;41(6):303-304

Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine, Houston, TX.

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http://dx.doi.org/10.1542/pir.2018-0064DOI Listing

Gastrointestinal involvement in childhood vasculitides.

Acta Paediatr 2020 Jun 1. Epub 2020 Jun 1.

Meyer Children's University Hospital and Department, NEUROFARBA, University of Florence, Viale Pieraccini 24, Florence, 50137, Italy.

Aim: The aim of this narrative review was to provide a comprehensive summary of the characteristics of gastrointestinal (GI) involvement in the most common paediatric primary vasculitides.

Methods: We used PubMed to primarily identify papers, reviews, case series and editorials published in English from 2000 until 31 January 2020. Based on this, we report the prevalence, clinical manifestations, diagnostic approaches and management of GI involvement in each vasculitis. Read More

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http://dx.doi.org/10.1111/apa.15381DOI Listing

Characteristics of Hospitalized Pediatric COVID-19 Cases - Chicago, Illinois, March - April 2020.

J Pediatric Infect Dis Soc 2020 Jun 1. Epub 2020 Jun 1.

Chicago Department of Public Health, Chicago, IL, USA.

Background: To date, no report on COVID-19 pediatric patients in a large urban center with data on underlying comorbidities and co-infection for hospitalized cases has been published.

Methods: Case series of Chicago COVID-19 patients aged 0-17 years reported to Chicago Department of Public Health (CDPH) from 3/5/20-4/8/20. Enhanced case investigation performed. Read More

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http://dx.doi.org/10.1093/jpids/piaa070DOI Listing

Pediatric coronavirus disease 2019 (COVID-19): An insight from west of Iran.

North Clin Istanb 2020 4;7(3):284-291. Epub 2020 May 4.

Department of Pathology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Objective: To study the clinical, laboratory, and radiological characteristics of the pediatric patients infected with the new emerging 2019 coronavirus virus (SARS-CoV-2) in Hamadan and Sanandaj, west of Iran.

Methods: A descriptive study was conducted in Hamadan and Kurdistan province between March 1 to April 15, 2020. Medical records of the children diagnosed as probable or confirmed cases of COVID-19 disease were extracted and analyzed in this study. Read More

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http://dx.doi.org/10.14744/nci.2020.90277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251275PMC

Differential Expression of Putative Defensins Mediated by Tick Feeding.

Front Cell Infect Microbiol 2020 5;10:152. Epub 2020 May 5.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.

Additional research on soft ticks in the family Argasidae is needed to bridge the knowledge gap relative to hard ticks of the family Ixodidae; especially, the molecular mechanisms of biology. species are vectors of human and animal pathogens that include tick-borne relapsing fever spirochetes and African swine fever virus. Soft tick vector-pathogen interactions involving components of the tick immune response are not understood. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232577PMC

Neonatal meningitis: a case report and literature review.

Transl Pediatr 2020 Apr;9(2):174-179

Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

() is common commensal in the female genitourinary tract. Despite has been associated with chorioamnionitis, abortion, prematurity and perinatal complications, the invasive central nervous system (CNS) infection is rare in neonates. Diagnosis of meningitis can be difficult for the atypical presentations and sterile cultures by conventional methods. Read More

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http://dx.doi.org/10.21037/tp.2020.02.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237967PMC

Analysis and suggestions for the preview and triage screening of children with suspected COVID-19 outside the epidemic area of Hubei Province.

Transl Pediatr 2020 Apr;9(2):126-132

National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Background: Since December 2019, a number of patients infected with COVID-19 (SARS-CoV-2) have been identified in Wuhan, Hubei, China. As the epidemic has spread, similar cases have also been found in other parts of mainland China and abroad. The main reason for this spread is the highly contagious nature of the virus and the fact that children can also become infected during its incubation period. Read More

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http://dx.doi.org/10.21037/tp.2020.03.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237977PMC

Cephalosporin-resistant typhoid.

SAGE Open Med Case Rep 2020 27;8:2050313X20917835. Epub 2020 Apr 27.

Department of Paediatrics, Bai Jerbai Wadia Hospital for Children, Mumbai, India.

Typhoid fever is endemic in developing countries like India. An increasing prevalence of resistance to cephalosporins and fluoroquinolones by Salmonella isolates is seen. We present an 8-month-old boy with invasive disease. Read More

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http://dx.doi.org/10.1177/2050313X20917835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233889PMC

Increased Prevalence of Q703K Variant Among Patients With Autoinflammatory Diseases: An International Multicentric Study.

Front Immunol 2020 14;11:877. Epub 2020 May 14.

Pediatric Rheumatology Unit of Western Switzerland, Pediatric Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

The inflammasome has been recognized as one of the key components of innate immunity. Gain-of-function mutations in the exon 3 of gene have been implicated in inflammatory diseases suggesting the presence of functionally important sites in this region. Q703K (c. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241420PMC

The contribution of diet preference to the disease course in children with familial Mediterranean fever: a cross-sectional study.

Reumatologia 2020 30;58(2):81-86. Epub 2020 Apr 30.

Department of Pediatric Gastroenterology, Cukurova University Faculty of Medicine, Adana, Turkey.

Objectives: Familial Mediterranean fever (FMF) is characterized by recurrent, self-limiting attacks of fever and serositis. Nutrition is very important in the management of chronic diseases. Previous studies suggested that salty and fatty diet cause inflammation, therefore we aimed to investigate the effects of dietary self-efficacy and behavior about low-salt or low-fat diet on disease course in children with FMF. Read More

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http://dx.doi.org/10.5114/reum.2020.95361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249529PMC

A clinical approach to non-neutropenic fever in children with cancer.

J Oncol Pharm Pract 2020 May 31:1078155220925161. Epub 2020 May 31.

King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.

Background: There are a limited number of studies that address non-neutropenic fever episodes in children with cancer, and no standard approach exists.

Method: We opt to retrospectively analyze the efficacy of the current clinical approach for management of non-neutropenic fever episodes and the associated risk factors among children with cancer at the Princess Noorah Oncology Center from May 2016 through December 2017.

Results: A total of 480 non-neutropenic fever episodes were identified in 131 children, of which 62 episodes were triaged as high-risk non-neutropenic fever and 418 as low-risk non-neutropenic fever. Read More

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http://dx.doi.org/10.1177/1078155220925161DOI Listing

Abiotrophia defectiva as a cause of infective endocarditis with embolic complications in children.

Infection 2020 May 30. Epub 2020 May 30.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Abiotrophia defectiva is a rare pathogen of infective endocarditis (IE) but is frequently involved in embolic complication and valvular dysfunction. IE caused by A. defectiva in children is poorly studied. Read More

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http://dx.doi.org/10.1007/s15010-020-01454-zDOI Listing

Hospitalizations for tuberculous peritonitis in the United States: Results from the national inpatient sample database from 2002 to 2014.

Int J Mycobacteriol 2020 Apr-Jun;9(2):167-172

Department of Pediatrics, Adolescent and Internal Medicine, Western Michigan University Homer Stryker M D School of Medicine, Kalamazoo, MI, USA.

Background: Tuberculosis (TB) is an uncommon disease in the Western hemisphere that can present with peritoneal involvement, as tuberculous peritonitis(TBP) causing abdominal pain and fever. The healthcare and economic burden of TBP in the United States remains unknown.

Methods: The National Inpatient Sample database was utilized to investigate TBP hospitalizations from 2002 to 2014. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_68_20DOI Listing

Infant With Fever and Shortness of Breath.

Ann Emerg Med 2020 Jun;75(6):e33-e34

Department of the Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1016/j.annemergmed.2019.12.014DOI Listing

Survey on knowledge, prescription habits, and management of fever among pediatricians at a children's hospital.

Arch Argent Pediatr 2020 Jun;118(3):209-213

División Promoción y Protección de la Salud, Área de Epidemiología, Hospital de Niños Ricardo GutiérrezCiudad Autónoma de Buenos Aires, Argentina.

Introduction: There are discrepancies in relation to pediatricians' approach to fever. Our objective was to describe the knowledge, prescription habits, and drug and non-drug treatment indications for fever among physicians at a children's hospital in the Autonomous City of Buenos Aires. Material and methods. Read More

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http://dx.doi.org/10.5546/aap.2020.eng.209DOI Listing

Clinical Practice Guideline Reduces Evaluation and Treatment for Febrile Infants 0 to 56 Days of Age.

Clin Pediatr (Phila) 2020 May 29:9922820920933. Epub 2020 May 29.

Departments of Emergency Medicine and Pediatrics, Alpert Medical School of Brown University, Providence, RI, USA.

Invasive bacterial infection (IBI) is associated with significant morbidity and mortality among neonates. Clinical practice guidelines (CPGs) can expedite care and standardize management. We conducted a retrospective observational study of febrile infants aged 0 to 56 days to assess changes in clinical decision-making following febrile neonate CPG implementation in the pediatric emergency department of a tertiary care hospital. Read More

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http://dx.doi.org/10.1177/0009922820920933DOI Listing

Severe acute kidney injury in a 3-year-old boy with fever and pleural effusion: Answers.

Pediatr Nephrol 2020 May 28. Epub 2020 May 28.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

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http://dx.doi.org/10.1007/s00467-020-04591-7DOI Listing

Severe acute kidney injury in a 3-year-old boy with fever and pleural effusion: Questions.

Pediatr Nephrol 2020 May 28. Epub 2020 May 28.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

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http://dx.doi.org/10.1007/s00467-020-04583-7DOI Listing

An Infant Presenting With Fever and Thrombocytopenia.

Pediatr Infect Dis J 2020 May 26. Epub 2020 May 26.

From the Department of Pediatrics, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

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http://dx.doi.org/10.1097/INF.0000000000002780DOI Listing

A Particular Form of "Urolithiasis" in a Toddler.

Pediatrics 2020 Jun;145(6)

Department of Woman, Child and General and Specialist Surgery, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.

Milk of calcium is a viscous colloidal suspension of calcium salts that forms in dilated cysts or cavities. We present, for the first time in literature, a toddler with isolated milk of calcium and treated with a conservative approach. A boy with a history of one urinary tract infection and recurrent fever without vesicoureteral reflux showed at the age of 14 months a left obstructive staghorn stone. Read More

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http://dx.doi.org/10.1542/peds.2019-3190DOI Listing

Late onset group B streptococcus disease manifesting as acute suppurative parotitis.

IDCases 2020 11;21:e00799. Epub 2020 May 11.

Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.

Few patients with acute suppurative parotitis (ASP) due to group B streptococcus (GBS) have been documented. Limited data on clinical and microbiological features and infectious route are available. We present a 21-day-old boy with invasive GBS disease manifesting as ASP. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242865PMC

Detection of circulating fungal DNA by polymerase chain reaction in a fatal case of infection.

IDCases 2020 11;20:e00760. Epub 2020 May 11.

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Introduction: although rarely causing mucormycosis, is responsible for the highest mortality among mucormycetes. The diagnosis of mucormycosis is challenged by the absence of specific biomarkers. Herein, we report a fatal case of infection and detection of its DNA in the serum by polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240320PMC

Bilateral Optic Neuritis: A Rare Complication of Mumps.

Cureus 2020 Apr 21;12(4):e7768. Epub 2020 Apr 21.

Pediatrics, United Medical and Dental College, Creek General Hospital, Karachi, PAK.

Mumps is a contagious viral illness that classically presents with fever, parotid gland swelling, headache, and vomiting in unimmunized children. The complications of mumps most commonly include orchitis, pancreatitis, encephalitis, and meningitis. Optic neuritis, which refers to the inflammation of the optic nerve, in rare cases, can present after mumps meningoencephalitis and causes pain in the eye, and a decrease in visual acuity. Read More

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http://dx.doi.org/10.7759/cureus.7768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243626PMC

Dengue Virus and Yellow Fever Virus Detection Using Reverse Transcription-Insulated Isothermal PCR and Comparison with Real-Time RT-PCR.

Am J Trop Med Hyg 2020 May 26. Epub 2020 May 26.

Department of Global Health, Rollins School of Public Health, Atlanta, Georgia.

Real-time reverse transcriptase PCR (rRT-PCR) is the most accurate method for the detection of dengue virus (DENV) and yellow fever virus (YFV) in acute illness. However, performing rRT-PCR is not feasible for many laboratories in regions of endemicity. The current study compared new reverse transcription-insulated isothermal PCRs (the POCKIT DENV and YFV reagent sets) with laboratory-developed rRT-PCRs for both viruses using clinical samples and viral strains from different endemic regions. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0892DOI Listing

Temperatures, diagnostics and treatment in pediatric cancer patients with fever in neutropenia, NCT01683370.

Sci Data 2020 May 26;7(1):156. Epub 2020 May 26.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, Freiburgstrasse 15, 3010, Bern, Switzerland.

In pediatric oncology, there is no evidence-based definition of the temperature limit defining fever (TLDF), which itself is essential for the definition of fever in chemotherapy-induced severe neutropenia (FN). Lowering the TLDF can increase the number of FN episodes diagnosed. This prospective, single center observational study collected data on all temperature measurements, complete blood counts (CBCs), and measures of diagnostics and therapy performed at and after FN diagnosis in pediatric oncology patients using a high standard TLDF (39 °C ear temperature). Read More

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http://dx.doi.org/10.1038/s41597-020-0504-9DOI Listing

Retrospective Descriptive Analysis of West Nile Neuroinvasive Disease (WNND) in Northwest Louisiana.

Int J Microbiol 2020 8;2020:3513859. Epub 2020 May 8.

Infectious Diseases, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.

Aims: The aim of the study was to describe the presentation characteristics and epidemiology of WNND in Louisiana to improve future recognition of cases and decrease inappropriate antibiotic use. . It was a retrospective descriptive-analytic cohort study. Read More

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http://dx.doi.org/10.1155/2020/3513859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231183PMC

Cefepime Versus Cefepime Plus Amikacin as an Initial Antibiotic Choice for Pediatric Cancer Patients With Febrile Neutropenia in an Era of Increasing Cefepime Resistance.

Pediatr Infect Dis J 2020 May 20. Epub 2020 May 20.

Department of Pediatrics.

Background: We investigated the treatment outcomes before and after the addition of amikacin to cefepime monotherapy as an initial empirical antibiotic treatment in pediatric cancer patients with febrile neutropenia.

Methods: This was a retrospective historical cohort study. The subjects were pediatric cancer patients who visited the emergency room at the Samsung Medical Center, Seoul, Korea, due to chemotherapy-induced febrile neutropenia, between January 2011 and December 2016. Read More

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http://dx.doi.org/10.1097/INF.0000000000002751DOI Listing

Extra-respiratory manifestations of COVID-19.

Int J Antimicrob Agents 2020 May 22:106024. Epub 2020 May 22.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global health threat. Although most patients with COVID-19 manifest fever and respiratory tract symptoms, SARS-CoV-2 infection may also involve other organs/systems and present with extra-respiratory manifestations, including cardiac, gastrointestinal, hepatic, renal, neurological, olfactory, gustatory, ocular, cutaneous and haematological symptoms. Occasionally, these extra-respiratory symptoms/signs represent the initial presentation of SARS-CoV-2 infection, prior to fever or respiratory manifestations. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243791PMC

Prediction Model for the Differential Diagnosis of Kawasaki Disease and Acute Cervical Lymphadenitis in Patients Initially Presenting with Fever and Cervical Lymphadenitis.

J Pediatr 2020 May 22. Epub 2020 May 22.

Department of Pediatrics, Hallym University College of Medicine, Kangdong Sacred Heart Hospital. Electronic address:

Objectives: To distinguish early-stage LFKD from ACL, we developed an algorithm using sequential laboratory marker levels and radiologic findings.

Study Design: Data were obtained from pediatric inpatients initially presenting with fever and cervical lymphadenopathy. Discriminative factors for the differential diagnosis of ACL and LFKD were identified from intergroup comparison or univariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.05.031DOI Listing

Nephrological disorders and neurological involvement in pediatric primary Sjogren syndrome:a case report and review of literature.

Pediatr Rheumatol Online J 2020 May 24;18(1):39. Epub 2020 May 24.

Department of Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, People's Republic of China.

Background: Sjögren syndrome (SS) is a rare disease in pediatrics, and little attention has been paid to the clinical feature in these patients. To date, there are few cases concern about neurological and nephrological disorders in childhood Sjögren syndrome. We describe a case of Sjögren syndrome in a 12-year-old girl who developed neurological disorders and interstitial nephritis and review the literature currently available on this topic. Read More

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http://dx.doi.org/10.1186/s12969-020-00431-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245745PMC

Pediatric COVID-19-associated rhabdomyolysis: a case report.

Pediatr Nephrol 2020 May 23. Epub 2020 May 23.

Division of Pediatric Nephrology, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA.

COVID-19 is the illness caused by infection with the novel coronavirus SARS-CoV-2. Although myalgia is common in adults, it has not been noted as a common symptom in children. There have been a few reported cases of COVID-19-associated rhabdomyolysis in adults. Read More

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http://dx.doi.org/10.1007/s00467-020-04617-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244938PMC

Clinical Characteristics of COVID-19 Infection in Newborns and Pediatrics: A Systematic Review.

Arch Acad Emerg Med 2020 18;8(1):e50. Epub 2020 Apr 18.

PhD Student of Nursing, Student Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: World Health Organization has declared COVID-19 a pandemic and a global health emergency. Thus, it is necessary to clearly characterize clinical manifestations and management of COVID-19 infection in children to provide accurate information for healthcare workers. Accordingly, the present study was designed to review articles published on clinical manifestations and characteristics of children and infants with COVID-19. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212072PMC

Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever.

J Clin Med 2020 May 19;9(5). Epub 2020 May 19.

Division of Emergency Medicine, Carman and Ann Adams Department of Pediatrics, Children's Hospital of MI, Detroit, MI 48201, USA.

Sickle cell disease (SCD) patients are thought to be at higher risk for urinary tract infections (UTIs) compared to the general population secondary to increased sickling, abnormal urinary acidification, and an inability to concentrate the urine. The incidence of UTI in febrile children with SCD in the United States is unknown. Our objectives were to determine the rate of UTI among febrile SCD children and describe the risk factors for UTI in this population. Read More

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http://dx.doi.org/10.3390/jcm9051531DOI Listing

The immunologic status of newborns born to SARS-CoV2-infected mothers in Wuhan, China.

J Allergy Clin Immunol 2020 May 10. Epub 2020 May 10.

Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, China.

Background: Immunologic dysfunction due to COVID-19 is closely related to clinical prognosis, and the inflammatory response of pregnant women may affect the directional differentiation and function of fetal immune cells.

Objective: To analyze the immune status of newborns from mothers with COVID-19 in the third trimester.

Methods: Along with collecting the clinical data from 51 newborns and their respective mothers, we also recorded the immunophenotypes and cytokine and immunoglobulin levels of the newborns. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211641PMC

Ebola-Specific CD8+ and CD4+ T Cell Responses in Sierra Leonean Ebola Virus Survivors with and without Post Viral Sequelae.

J Infect Dis 2020 May 21. Epub 2020 May 21.

Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, Scripps Research, La Jolla, USA.

Background: Ebola virus disease has killed thousands of West and Central Africans over the past several decades. Many who survive the acute disease later suffer from post Ebola syndrome (PES), a constellation of symptoms whose causative pathogenesis is unclear.

Methods: We investigated Ebola virus (EBOV)-specific CD8+ and CD4+ T cell responses in 37 Sierra Leonean EBOV disease survivors with (N=19) and without sequelae (N=18) of arthralgia and ocular symptoms. Read More

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http://dx.doi.org/10.1093/infdis/jiaa268DOI Listing
May 2020
5.997 Impact Factor

Late-onset argininosuccinic aciduria associated with hyperammonemia triggered by influenza infection in an adolescent: A case report.

Mol Genet Metab Rep 2020 Sep 15;24:100605. Epub 2020 May 15.

Department of Pediatrics, Gunma University Graduate School of Medicine, Japan.

Hyperammonemia is a typical symptom of urea cycle disorders. While early-onset argininosuccinic aciduria (ASA) can often be detected by hyperammonemia, patients with late-onset ASA predominantly present with psychomotor retardation and mental disorders. However, in late-onset ASA that develops during early childhood, hyperammonemia can sometimes be caused by acute infections, stress, and reduced dietary intake. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2020.100605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232106PMC
September 2020

Relation between Febrile Seizure Recurrence and Hyponatremia in Children: A Single-center Trial.

J Pediatr Neurosci 2020 Jan-Mar;15(1):5-8. Epub 2020 Feb 18.

Pediatric Division, Bou Ali-Sina Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Febrile seizure (FS) is one of the most common types of seizure in pediatrics.

Objective: The aim of this study was to compare serum sodium in children with simple or recurrent FS and seizure without fever.

Materials And Methods: This was a cross-sectional prospective study conducted between September 2015 and April 2017 in patients aged between 6 months and 6 years, who were admitted to a tertiary educational medical center in the north of Iran. Read More

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http://dx.doi.org/10.4103/JPN.JPN_4_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227756PMC
February 2020

[SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS CAUSED BY A HUMIDIFIER INDUCED IN SPRING, IN A 5-YEAR-OLD GIRL LIVING IN FUKUSHIMA-A CASE REPORT].

Arerugi 2020 ;69(3):204-208

Department of Pediatrics, Hoshi General Hospital.

A 5-year-old girl living in Koriyama, Fukushima Prefecture was admitted in April with cough persisting for 1 month and fever. Chest X-ray showed diffuse ground-glass shadows in both lungs. After treatment with antibiotics, her fever went down on the 2 day, and her cough subsided gradually. Read More

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http://dx.doi.org/10.15036/arerugi.69.204DOI Listing
January 2020

[Clinical features of coronavirus disease 2019 in children aged <18 years in Jiangxi, China: an analysis of 23 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):419-424

Department of Pediatrics, Jiangxi Provincial Children's Hospital/Children's Hospital, Nanchang University, Nanchang 330006, China.

Objective: To study the clinical features of coronavirus disease 2019 (COVID-19) in children aged <18 years.

Methods: A retrospective analysis was performed from the medical data of 23 children, aged from 3 months to 17 years and 8 months, who were diagnosed with COVID-19 in Jiangxi, China from January 21 to February 29, 2020.

Results: Of the 23 children with COVID-19, 17 had family aggregation. Read More

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Classic Hodgkin Lymphoma: A Nonclassic Presentation.

J Pediatr Hematol Oncol 2020 May 19. Epub 2020 May 19.

Division of Pediatric Hematology/Oncology, University of California Davis Medical Center, Sacramento, CA.

Hodgkin lymphoma classically presents as lymphadenopathy with contiguous spread with or without associated B symptoms including night sweats, weight loss, and fever. With timely diagnosis and treatment, this is a potentially curable disease. This report describes a unique case of Hodgkin lymphoma that presented with localized back pain without overt evidence of lymph node involvement. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001825DOI Listing