15,406 results match your criteria Pediatrics Fever


Nomogram for diagnosing acute pyelonephritis in pediatric urinary tract infection.

Pediatr Neonatol 2022 Apr 12. Epub 2022 Apr 12.

Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung and School of Medicine, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Background: For risk stratification and individualized treatment for children with urinary tract infection (UTI), they must be assessed for the presence of acute pyelonephritis (APN). Our study aimed to combine variables that can predict APN and establish a nomogram for clinical use.

Methods: In total, 111 children <5 years old hospitalized at Kaohsiung Veterans General Hospital for UTI were classified into APN and simple UTI groups based on a technetium-99 m dimercaptosuccinic acid scan. Read More

View Article and Full-Text PDF

Editorial to: Advance in the Treatment of Pediatric Leukemia.

J Clin Med 2022 Apr 22;11(9). Epub 2022 Apr 22.

Department I-General Pediatrics, Hematology/Oncology, Children's Hospital, University Hospital Tübingen, 72076 Tübingen, Germany.

The history of leukemia goes back many years and John Bennet, a Scottish physician, described in 1845 a 28-year old patient with swelling of the spleen who then developed fever, bleeding and increasing swellings in his neck, groin and armpits [... Read More

View Article and Full-Text PDF

The Effective Management of Fever in Pediatrics and Insights on Remote Management: Experts' Consensus Using a Delphi Approach.

Front Pediatr 2022 26;10:834673. Epub 2022 Apr 26.

Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.

Background: Even after the publication of the 2017 update of Italian guidelines on treatment of fever in pediatrics, some fundamental questions are still open and new ones emerged during the COVID-19 pandemic.

Objective: To assess the level of consensus among Italian pediatricians on different topics related to treatment of fever in children by using the Delphi technique.

Methods: A Delphi study was undertaken between June and September 2021, when two questionnaires were consecutively sent to a panel of experts to be answered anonymously. Read More

View Article and Full-Text PDF

Risk Factors and Outcomes Associated With Antibiotic Therapy in Children Hospitalized With Asthma Exacerbation.

J Pediatr Pharmacol Ther 2022 9;27(4):366-372. Epub 2022 May 9.

Department of Pediatrics (AP), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Objective: Despite lack of benefit, antibiotics are overused in management of asthma exacerbation in children. In this study, data from a single children's hospital were analyzed to identify factors and outcomes associated with antibiotic use in children hospitalized with asthma.

Methods: The study population was identified by using administrative data from 2012 to 2015, with subsequent verification of asthma. Read More

View Article and Full-Text PDF

Biomarker combinations in predicting sepsis in hospitalized children with fever.

BMC Pediatr 2022 May 12;22(1):272. Epub 2022 May 12.

Department of Pediatrics, Riga Stradins University, Riga, LV1007, Latvia.

Sepsis is among the leading causes of critical illness worldwide. It includes physiologic, pathologic, and biochemical abnormalities, induced by infection. Novel methods for recognizing a dysregulated inflammatory response and predicting associated mortality must be developed. Read More

View Article and Full-Text PDF

Bartonella endocarditis and diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition.

BMC Nephrol 2022 May 12;23(1):181. Epub 2022 May 12.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: Bartonella endocarditis is often a diagnostic challenge due to its variable clinical manifestations, especially when it is first presented with involvement of organs other than skin and lymph nodes, such as the kidney.

Case Presentation: This was a 13-year-old girl presenting with fever, chest and abdominal pain, acute kidney injury, nephrotic-range proteinuria and low complement levels. Her kidney biopsy showed diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition shown by immunofluorescence, which was initially considered consistent with systemic lupus erythematous-associated glomerulonephritis (lupus nephritis). Read More

View Article and Full-Text PDF

The Added Value of a Multidisciplinary Clinic for Systemic Autoinflammatory Diseases.

J Multidiscip Healthc 2022 4;15:999-1010. Epub 2022 May 4.

Pediatric Rheumatology Unit, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Background: Systemic autoinflammatory diseases (SAID) are characterized by inappropriate activation of the innate immune system and include not only monogenic periodic fever syndromes but also multifactorial conditions. As SAID are rare and represent a diagnostic challenge, a multidisciplinary approach is important to ensure successful diagnosis and adequate follow-up of these patients.

Objective: To describe the organization of our multidisciplinary SAID clinic and to characterize our clinical experience, highlighting the benefits of multidisciplinary team management. Read More

View Article and Full-Text PDF

Integrating Clinical Signs at Presentation and Clinician's Non-analytical Reasoning in Prediction Models for Serious Bacterial Infection in Febrile Children Presenting to Emergency Department.

Front Pediatr 2022 25;10:786795. Epub 2022 Apr 25.

Department of Pediatrics, Riga Stradins University, Riga, Latvia.

Objective: Development and validation of clinical prediction model (CPM) for serious bacterial infections (SBIs) in children presenting to the emergency department (ED) with febrile illness, based on clinical variables, clinician's "gut feeling," and "sense of reassurance.

Materials And Methods: Febrile children presenting to the ED of Children's Clinical University Hospital (CCUH) between April 1, 2017 and December 31, 2018 were enrolled in a prospective observational study. Data on clinical signs and symptoms at presentation, together with clinician's "gut feeling" of something wrong and "sense of reassurance" were collected as candidate variables for CPM. Read More

View Article and Full-Text PDF

Supporting the gastrointestinal microenvironment during high-dose chemotherapy and stem cell transplantation by inhibiting IL-1 signaling with anakinra.

Sci Rep 2022 May 11;12(1):6803. Epub 2022 May 11.

Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.

High-dose chemotherapy causes intestinal inflammation and subsequent breakdown of the mucosal barrier, permitting translocation of enteric pathogens, clinically manifesting as fever. Antibiotics are mainstay for controlling these complications, however, they are increasingly recognized for their detrimental effects, including antimicrobial resistance and dysbiosis. Here, we show that mucosal barrier injury induced by the mucotoxic chemotherapeutic agent, high-dose melphalan (HDM), is characterized by hyper-active IL-1b/CXCL1/neutrophil signaling. Read More

View Article and Full-Text PDF

Next-Generation Sequencing Analysis of MVK, NLRP3, TNFRSF1A, and PSTPIP1 Genes in Patients without MEFV Gene Variation and Genotype-Phenotype Correlation.

Eur J Rheumatol 2022 04;9(2):62-67

Department of Pediatrics, Divisionof Molecular Biology, Ege University School of Medicine, İzmir, Turkey.

Objective: In this study, we aimed to evaluate other interleukin-1b-mediated monogenic autoinflam- matory diseases (AIDs) (tumor necrosis factor receptor-1-associated periodic syndrome, hyperimmuno- globulin D syndrome, cryopyrin-associated periodic syndrome (CAPS), pyogenic arthritis, pyoderma gangrenosum, and acne syndrome) by the next-generation sequencing method (NGS) in cases with clinical Familial Mediterranean Fever symptoms, and no variant detected in the MEFV gene. Methods: The cases included in this study and their parents were interviewed and filled in a survey form. The targeted genetic panel for interleukin-1b-mediated AIDs covering four genes (MVK, NLRP3,TNFRSF1A, and PSTPIP1) was studied for cases with a negative result from the MEFV gene analysis. Read More

View Article and Full-Text PDF

COVID-19 infections in infants.

Sci Rep 2022 May 11;12(1):7765. Epub 2022 May 11.

Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

The study aimed to analyse the clinical course of COVID-19 in 300 infants, selected from 1283 children diagnosed with COVID-19 between March and December 2020, registered in the SARSTerPED multicenter database. Most of the infants were registered in October and November 2020. 44% of the group were girls, and 56% were boys. Read More

View Article and Full-Text PDF

Antibody Seronegativity in COVID-19 RT-PCR-Positive Children.

Pediatr Infect Dis J 2022 May 9. Epub 2022 May 9.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

This substudy of a prospective case-ascertained household transmission study investigated severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction-positive individuals without antibody development and factors associated with nonseroconversion. Approximately 1 of 8 individuals with coronavirus disease 2019 did not seroconvert. Children, particularly the youngest, were approximately half as likely to seroconvert compared with adults. Read More

View Article and Full-Text PDF

Prevalence of Cardiac Dysfunction in Malawian Children With Severe Febrile Illness.

Pediatr Crit Care Med 2022 May 11. Epub 2022 May 11.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

Objectives: To investigate the prevalence of left ventricular systolic dysfunction (LVSD) in Malawian children with severe febrile illness and to explore associations between LVSD and mortality and lactate levels.

Design: Prospective observational study.

Setting: Pediatric ward of a tertiary government referral hospital in Malawi. Read More

View Article and Full-Text PDF

Dengue: A Growing Problem With New Interventions.

Pediatrics 2022 May 11. Epub 2022 May 11.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico.

Dengue is the disease caused by 1 of 3 distinct, but closely related dengue viruses (DENV-1-4) that are transmitted by Aedes spp. mosquito vectors. It is the most common arboviral disease worldwide, with the greatest burden in tropical and sub-tropical regions. Read More

View Article and Full-Text PDF

Diagnosis and Prognostic Analysis of Pneumonia in Children Based on High-Resolution Computed Tomography.

Contrast Media Mol Imaging 2022 22;2022:1985531. Epub 2022 Apr 22.

Department of Pediatrics, Funan County People's Hospital, Funan County, Fuyang City 236300, Anhui Province, China.

Mycoplasma (MP) is defined as a common cause of pulmonary infections and accounts for up to four over ten of pneumonia in children over age 5. This study was aimed to explore the diagnosis and prognosis of mycoplasma pneumonia (MPP) in children using high-resolution computed tomography (CT) (HRCT). 71 children hospitalized with MPP were undertaken as the research objects to observe the incidence rate, occurrence time, and duration of the clinical symptoms and pathological signs. Read More

View Article and Full-Text PDF

COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI - the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases.

RMD Open 2022 May;8(1)

Sorbonne University, AP-HP, Tenon Hospital, Internal Medicine Department, 4 rue de la Chine, 75020, Paris, France; national Reference center for autoinflammatory diseases and AA amyloidosis (CEREMAIA), Tenon Hospital, Paris, France

Objective: There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared. Read More

View Article and Full-Text PDF

Short Stature as an Initial Presenting Presentation of Unicentric Castleman Disease in a Child: A Case Report With Long-Term Follow-Up and a Literature Review.

Mod Rheumatol Case Rep 2022 May 10. Epub 2022 May 10.

Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.

Short stature is a common clinical condition in pediatric outpatient clinics and is associated with various clinical conditions, ranging from normal variants to severe diseases. Short stature is known to be caused by chronic inflammatory conditions, in which over-produced inflammatory cytokines are reported to be involved in growth suppression. Castleman disease is a rare lymphoproliferative disorder known as a chronic inflammatory disease with overproduction of interleukin 6 (IL-6), which often causes systemic symptoms such as fever, fatigue, weight loss, and night sweats. Read More

View Article and Full-Text PDF

Molecular Study of Adenovirus Genotypes 40 and 41 in Children with Acute Gastroenteritis.

Infect Disord Drug Targets 2022 May 9. Epub 2022 May 9.

Department of Clinical Pathology, Mansoura Faculty of Medicine.

Background: Adenovirus is a common virus associated with acute gastroenteritis in children. There are certain genotypes that are prevalent in these infections such as genotypes 40 and 41.

Objective: The aim of the present study was to investigate the incidence of adenovirus genotypes 40 and 41 in children with acute gastroenteritis by polymerase chain reaction (PCR) and also to determine the possibility of Adenovirus co-infections with Rota virus. Read More

View Article and Full-Text PDF

Infection-Induced Elevated Plasma Perampanel in a Patient with Hemimegalencephaly.

Case Rep Pediatr 2022 29;2022:9844820. Epub 2022 Apr 29.

National Hospital Organization Kumamoto Saishun Medical Center, Department of Pediatrics, Koshi, Japan.

Perampanel is a noncompetitive, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor antagonist. Herein, we report a case of increased perampanel plasma concentration and impaired consciousness triggered by an infection. The patient had refractory epilepsy associated with hemimegalencephaly. Read More

View Article and Full-Text PDF

Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions.

Front Pediatr 2022 21;10:858945. Epub 2022 Apr 21.

Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, AOU "Policlinico", PO "G. Rodolico", Catania, Italy.

In addition to central nervous system infections, seizures and fever may occur together in several neurological disorders. Formerly, based on the clinical features and prognostic evolution, the co-association of seizure and fever included classical febrile seizures (FS) divided into simple, complex, and prolonged FS (also called febrile status epilepticus). Later, this group of disorders has been progressively indicated, with a more inclusive term, as "fever-associated seizures or epilepsy" (FASE) that encompasses: (a) FS divided into simple, complex, and prolonged FS; (b) FS plus; (c) severe myoclonic epilepsy in infancy (Dravet syndrome); (d) genetic epilepsy with FS plus; and (e) febrile infection-related epilepsy syndrome (FIRES). Read More

View Article and Full-Text PDF

Prevalence and predicting factors of Group A beta-hemolytic state in primary schoolchildren.

Ann Pediatr Cardiol 2021 Oct-Dec;14(4):471-475. Epub 2022 Mar 25.

Molecular Bacteriology Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia.

Introduction: Transmission of Group A from asymptomatic children to their surrounding carries a risk of acute rheumatic fever in susceptible people.

Aim And Objectives: We aimed to investigate the prevalence and predictors of GAS carrier state and evaluate the antibiotic sensitivity pattern of GAS in Jakarta, Indonesia.

Material And Methods: We enrolled 201 asymptomatic schoolchildren (6-12 years) using stratified random sampling from a primary school in Jakarta. Read More

View Article and Full-Text PDF

[Clinical features of children with colorectal polyps and the efficacy of endoscopic treatment: an analysis of 1 351 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2022 Apr;24(4):354-359

Department of Gastroenterology/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics/Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Objectives: To study the clinical features of children with colorectal polyps and the efficacy of endoscopic treatment.

Methods: A retrospective analysis was performed on the medical data of 1 351 children with colorectal polyps who were admitted and received colonoscopy and treatment in the past 8 years, including clinical features and the pattern and outcomes of endoscopic treatment.

Results: Among the 1 351 children, 893 (66. Read More

View Article and Full-Text PDF

A 16-Year-Old-Girl With Asthma, Palpable Purpura, and Hypereosinophilia.

Chest 2022 May;161(5):e305-e308

Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India.

Case Presentation: A 16-year-old girl presented to the ED with complaints of loose stools, abdominal pain, and rash over her legs for the last 7 days. There was no history of fever, vomiting, oral ulcers, or mucosal bleeds. In the past, she had received a diagnosis of asthma. Read More

View Article and Full-Text PDF

Neurological manifestations in mevalonate kinase deficiency: A systematic review.

Mol Genet Metab 2022 Apr 30. Epub 2022 Apr 30.

Sorbonne University, Department of Internal Medicine, AP-HP, Hôpital Tenon, Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses Inflammatoire (CEREMAIA), Paris, France. Electronic address:

Introduction: Mevalonate kinase deficiency (MKD) is a monogenic auto-inflammatory disease. Its manifestations range from partial MKD to mevalonic aciduria (MVA). All patients display a periodic fever, and MVA patients additionally exhibit severe neurological involvement. Read More

View Article and Full-Text PDF

A prediction model for bacteremia and transfer to intensive care in pediatric and adolescent cancer patients with febrile neutropenia.

Sci Rep 2022 May 6;12(1):7429. Epub 2022 May 6.

Department of Pediatrics, Division of Infectious Diseases, University of Chicago Medicine, Chicago, IL, USA.

Febrile neutropenia (FN) is a common condition in children receiving chemotherapy. Our goal in this study was to develop a model for predicting blood stream infection (BSI) and transfer to intensive care (TIC) at time of presentation in pediatric cancer patients with FN. We conducted an observational cohort analysis of pediatric and adolescent cancer patients younger than 24 years admitted for fever and chemotherapy-induced neutropenia over a 7-year period. Read More

View Article and Full-Text PDF

Predictors of hematoma as a complication in pediatric kidney biopsies.

Pediatr Int 2022 Jan;64(1):e15189

Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Background: Kidney biopsies are crucial in the diagnosis of kidney diseases but they carry the risk of various complications, most commonly hematoma. Here we tried to identify the predictors of hematomas as a complication of kidney biopsies and we constructed an algorithm to stratify the risk.

Methods: The present report retrospectively reviewed 118 pediatric percutaneous kidney biopsies of native kidneys in 102 children (59 females) with the median age of 9 years (range: 1-19 years) at Kumamoto University Hospital between August 2008 and October 2019. Read More

View Article and Full-Text PDF
January 2022

Drivers of long-lasting insecticide-treated net utilisation and parasitaemia among under-five children in 13 States with high malaria burden in Nigeria.

PLoS One 2022 6;17(5):e0268185. Epub 2022 May 6.

High Impact Africa 1 Department, Global Fund to Fight AIDS, TB and Malaria, Geneva, Switzerland.

Background: Although Nigeria has made some progress in malaria control, there are variations across States. We investigated the factors associated with utilisation of long-lasting insecticide-treated net (LLIN) and parasitaemia among under-five children in 13 States with high malaria burden.

Method: Data from the 2015 Nigeria Malaria Indicator Survey and 2018 Demographic and Health Survey were obtained and analysed. Read More

View Article and Full-Text PDF

Multiple tuberculomas and cavitating pulmonary tuberculosis in an infant.

J Family Med Prim Care 2022 Apr 18;11(4):1536-1538. Epub 2022 Mar 18.

Department of Pediatrics, Bangalore Baptist Hospital, Bengaluru, Karnataka, India.

A five-month-old infant presented with fever and cough for 3 weeks. She was diagnosed with multiple tuberculomas and cavitating pulmonary tuberculosis. She was a household contact of an open case of tuberculosis (TB) and developed severe disease, although she had received the Bacillus Calmette-Guérin (BCG) vaccine and had no primary or secondary immunodeficiency. Read More

View Article and Full-Text PDF

An Observational Study on Clinical and Epidemiological Profile of Pediatric Patients with Coronavirus Disease 2019 (COVID-19) Presenting With Comorbidities at RIMS, Ranchi.

J Family Med Prim Care 2022 Apr 18;11(4):1493-1496. Epub 2022 Mar 18.

Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

Introduction: SARS COVID-19 infection leads to wide range of symptoms in comorbid pediatric patient. In view of its susceptibility affecting pediatric age groups with comorbidities and its potential to increase the mortality rate, it may have adverse effects on the outcome of such children. This study aims at better understanding of clinical profile and its outcome of pediatric population. Read More

View Article and Full-Text PDF

Interventional closure of a bronchopleural fistula in a 2 year old child with detachable coils.

BMC Pediatr 2022 05 5;22(1):250. Epub 2022 May 5.

Department Paediatrics 2, Pulmonology, Cardiology, Intensive Care, Children's Hospital, University of Tuebingen, Hoppe-Seyler-Strasse 1, 72076, Tuebingen, Germany.

Background: Bronchopleural fistula (BPF) is a severe complication following pneumonia or pulmonary surgery, resulting in persistent air leakage (PAL) and pneumothorax. Surgical options include resection, coverage of the fistula by video-assisted thoracoscopic surgery (VATS), or pleurodesis. Interventional bronchoscopy is preferred in complex cases and involves the use of sclerosants, sealants and occlusive valve devices. Read More

View Article and Full-Text PDF