11,176 results match your criteria Pediatrics Fever


Epidemiologic, clinical, and laboratory characteristics of childhood brucellosis : A study in an Iranian children's referral hospital.

Wien Med Wochenschr 2019 Feb 18. Epub 2019 Feb 18.

Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Brucellosis is endemic in Iran. Children constitute 20-25% of cases. We determined clinical, laboratory, and epidemiologic characteristics of pediatric brucellosis patients hospitalized at the Children's Medical Center from May 2011 to December 2016. Read More

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http://dx.doi.org/10.1007/s10354-019-0685-zDOI Listing
February 2019

A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections.

JAMA Pediatr 2019 Feb 18. Epub 2019 Feb 18.

Division of Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan.

Importance: In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and meningitis, may lead to dangerous complications. However, lumbar punctures and hospitalizations involve risks and costs. Clinical prediction rules using biomarkers beyond the white blood cell count (WBC) may accurately identify febrile infants at low risk for SBIs. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2018.5501DOI Listing
February 2019
1 Read

Association of ficolin-2 (FCN2) functional polymorphisms and protein levels with rheumatic fever and rheumatic heart disease: relationship with cardiac function.

Arch Med Sci Atheroscler Dis 2018 15;3:e142-e155. Epub 2018 Dec 15.

Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Introduction: A role for ficolin (FCN) 2 gene polymorphisms in the pathogenesis of recurrent severe streptococcal infections and rheumatic carditis has been suggested. The aim of the study was to evaluate a possible relationship between single nucleotide polymorphisms located at positions -602 and -4 of the FCN2 gene and FCN2 serum levels and risk of development of rheumatic fever (RF) and rheumatic heart disease (RHD).

Material And Methods: Seventy-seven Caucasian Egyptian patients with RF were recruited with a control group of 43 healthy subjects. Read More

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http://dx.doi.org/10.5114/amsad.2018.80999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374577PMC
December 2018

Intima media thickness as an early predictor of atherosclerosis in Egyptian children with familial Mediterranean fever.

Arch Med Sci Atheroscler Dis 2018 7;3:e106-e111. Epub 2018 Aug 7.

Department of Pediatrics, National Research Centre, Dokki, Egypt.

Introduction: Familial Mediterranean fever (FMF) is an autosomal recessive disease. It is characterized by recurrent crises of fever and serosal inflammation. Although FMF patients are symptom free in between attacks, subclinical inflammation continues during the attack-free period. Read More

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http://dx.doi.org/10.5114/amsad.2018.77545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374578PMC

A case report of acute rheumatic fever and a brief review of the literature.

Arch Med Sci Atheroscler Dis 2018 28;3:e80-e82. Epub 2018 Jun 28.

Department of Pediatrics, Shanghai Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

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http://dx.doi.org/10.5114/amsad.2018.76825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374571PMC

Path analyses of risk factors for linear growth faltering in four prospective cohorts of young children in Ghana, Malawi and Burkina Faso.

BMJ Glob Health 2019 13;4(1):e001155. Epub 2019 Jan 13.

Department of Nutrition, University of California Davis, Davis, California, USA.

Stunting prevalence is an indicator of a country's progress towards United Nations' Sustainable Development Goal 2, which is to end hunger and achieve improved nutrition. Accelerating progress towards reducing stunting requires a deeper understanding of the factors that contribute to linear growth faltering. We conducted path analyses of factors associated with 18-month length-for-age z-score (LAZ) in four prospective cohorts of children who participated in trials conducted as part of the International Lipid-Based Nutrient Supplements Project in Ghana (n=1039), Malawi (n=684 and 1504) and Burkina Faso (n=2619). Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350712PMC
January 2019

First Report of a Disease by Rhazes 10 Centuries Ago.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Department of Anesthesiology and Intensive Care Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Abu Bakr Mohammad Ibn Zakariya Al-Razi (865-925 CE), who was known as "Rhazes" in the west, was a famous scientist of medieval ages. He has more than 200 books and treatises. His masterpiece on medicine "" contains around 900 case reports. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_216_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360843PMC
January 2019

Results of endoscopic nasal surgery in the treatment of invasive fungal sinusitis in children with cancer and immunosuppression.

Acta Otorrinolaringol Esp 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Otorrinolaringología, Centro Clínico de Cabeza y Cuello, Ciudad de Guatemala, Guatemala.

Background And Objective: to describe the results of the treatment of invasive fungal sinusitis with nasal endoscopic surgery in an immunocompromised paediatric oncological population.

Methods: retrospective study of all patients diagnosed with invasive fungal sinusitis operated in the National Paediatric Oncology Unit between 2012 and 2016. Data taken from their medical history included: epidemiological characteristics, oncological diagnosis, haematological data, symptoms, tomographic studies, surgical interventions, results of pathology and cultures, medications received, complications, evolution and survival. Read More

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http://dx.doi.org/10.1016/j.otorri.2018.09.001DOI Listing
February 2019

Pediatric preseptal and orbital cellulitis: A 10-year experience.

Int J Pediatr Otorhinolaryngol 2019 Feb 7;120:82-88. Epub 2019 Feb 7.

Pediatrics Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

Objective: Characterize clinical features, epidemiology and treatment of hospitalized pediatric cases of preseptal and orbital cellulitis.

Methods: Retrospective study of children/adolescents admitted to a central hospital with preseptal and orbital cellulitis between 2007 and 2017.

Results: A total of 122 cases were included, 80. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.003DOI Listing
February 2019

Severe cryopyrin-associated periodic syndrome first characterized by early childhood-onset sensorineural hearing loss - Case report and literature review.

Int J Pediatr Otorhinolaryngol 2019 Jan 28;120:68-72. Epub 2019 Jan 28.

Division of Pediatric Rheumatology, Department of Pediatrics, IWK Health Centre, 5850/5980 University Ave, PO Box 9700, Halifax, NS, B3K 6R8, Canada. Electronic address:

Infant-onset bilateral sensorineural hearing loss is a key presenting symptom of the autoinflammatory cryopyrin-associated periodic syndrome. Other symptoms include periodic fever, cold-induced urticaria-like rash, chronic aseptic meningitis, polyarticular arthralgias, and renal AA amyloidosis. Early recognition and treatment with interleukin-1 blockade are critical for preventing disabling or fatal complications. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.037DOI Listing
January 2019

Acute Respiratory Illness in Rural Haiti.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL. USA.

Objectives: Acute Respiratory Infection (ARI) is the most common cause of childhood morbidity and mortality in developing countries, including Haiti. Our objective was to detect pathogens found in children with ARI in rural Haiti to help develop evidence-based guidelines for treatment and prevention.

Methods: Retrospective study of students with ARI at four schools in rural Haiti. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.003DOI Listing
February 2019

Candida Tropicalis Renal Microabscesses in a Child with Leukemia Confirmed Using Nucleic Acid Amplification and Recovery after Prolonged Antifungal and Corticosteroid Treatment.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.002DOI Listing
February 2019

Non-occlusive intestinal ischemia in the ascending colon and rectum: a pediatric case occurring during encephalitis treatment.

Surg Case Rep 2019 Feb 15;5(1):23. Epub 2019 Feb 15.

Department of Pediatrics, Yamanashi Prefectural Central Hospital, Kofu, Japan.

Background: Non-occlusive mesenteric ischemia (NOMI) is a rare and severe pathological condition that can cause intestinal necrosis without mechanical obstruction of the mesenteric artery. NOMI often develops during the treatment of severe disease in elderly patients and mostly occurs in the intestine supplied by the superior mesenteric artery (SMA). We experienced a 12-year-old patient with NOMI that was segmentally localized in the ascending colon and rectum during encephalitis treatment. Read More

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https://surgicalcasereports.springeropen.com/articles/10.118
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http://dx.doi.org/10.1186/s40792-019-0592-yDOI Listing
February 2019
3 Reads

Introduction of Typhoid Conjugate Vaccines in Africa and Asia.

Clin Infect Dis 2019 Feb;68(Supplement_1):S27-S30

PATH, Seattle, Washington.

Typhoid fever continues to be a major public health concern, particularly in many low- and middle-income countries. The current threats of increasing antimicrobial resistance, urbanization, and climate change elevate the urgency for better prevention and control efforts for typhoid fever. In 2017, the results of ground-breaking research on typhoid conjugate vaccines (TCVs), the World Health Organization prequalification of a TCV, and global policy and financing decisions have set the stage for the introduction of TCVs into routine immunization programs in endemic countries. Read More

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https://academic.oup.com/cid/article/68/Supplement_1/S27/532
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http://dx.doi.org/10.1093/cid/ciy878DOI Listing
February 2019
1 Read

Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.

Pediatr Rheumatol Online J 2019 Feb 14;17(1). Epub 2019 Feb 14.

Division of Immunolgy, Boston Children's Hospital, Boston, MA, USA.

Background: Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HLH/MAS independently, is needed. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-019-0309-6DOI Listing
February 2019
4 Reads

Immunogenicity and safety of an intramuscular split-virion quadrivalent inactivated influenza vaccine in individuals aged ≥ 6 months in India.

Hum Vaccin Immunother 2019 Feb 14. Epub 2019 Feb 14.

i Sanofi Pasteur , Lyon , France.

A quadrivalent split-virion inactivated influenza vaccine (IIV4; Fluzone® Quadrivalent, Sanofi Pasteur) has been available in the US since 2013 for individuals aged ≥ 6 months. Here, we describe the results of an open-label, multicenter trial (WHO Universal Trial Number U1111-1143-8370) evaluating the immunogenicity and safety of IIV4 in Indian children aged 6-35 months and 3-8 years, adolescents aged 9-17 years, and adults aged ≥ 18 years (n = 100 per group). Post-vaccination hemagglutination inhibition titers for all strains in all age groups were ≥ 8 fold higher than at baseline (range, 8-51). Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1
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http://dx.doi.org/10.1080/21645515.2019.1565259DOI Listing
February 2019
2 Reads

A Controlled Human Infection Model of Group A Pharyngitis: Which Strain and Why?

mSphere 2019 Feb 13;4(1). Epub 2019 Feb 13.

Tropical Diseases, Murdoch Children's Research Institute, Melbourne, Victoria, Australia

Group A (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for strain selection is central to meeting ethical, scientific, and regulatory requirements. Read More

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http://dx.doi.org/10.1128/mSphere.00647-18DOI Listing
February 2019

The Association Between Fever and Subsequent Deterioration Among Hospitalized Children With Elevated PEWS.

Hosp Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Section of Hospital Medicine, Department of Pediatrics, School of Medicine, and.

Objectives: To evaluate the association between fever and subsequent deterioration among patients with Pediatric Early Warning Score (PEWS) elevations to ≥4 to inform improvements to care escalation processes at our institution.

Methods: We performed a cohort study of hospitalized children at a single quaternary children's hospital with PEWS elevations to ≥4 between January 1, 2014 and March 31, 2014. Bivariable analysis was used to compare characteristics between patients with and without unplanned ICU transfers and critical deterioration events (CDEs) (ie, unplanned ICU transfers with life-sustaining interventions initiated in the first 12 ICU hours). Read More

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http://dx.doi.org/10.1542/hpeds.2018-0187DOI Listing
February 2019

Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency.

Int J Hematol 2019 Feb 13. Epub 2019 Feb 13.

Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Mutation in the gene encoding tRNA nucleotidyl transferase, CCA-adding 1 (TRNT1), an enzyme essential for the synthesis of the 3'-terminal CCA sequence in tRNA molecules, results in a disorder that features sideroblastic anemia, B-cell immunodeficiency, periodic fever, and developmental delay. Mutations in TRNT1 are also linked to phenotypes including retinitis pigmentosa, cataracts, and cardiomyopathy. To date, it has remained unclear how defective TRNT1 is linked to B-cell deficiency. Read More

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http://link.springer.com/10.1007/s12185-019-02614-0
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http://dx.doi.org/10.1007/s12185-019-02614-0DOI Listing
February 2019
4 Reads

Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following S. aureus Acute Hematogenous Osteoarticular Infections in Children.

Clin Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX.

Background: Staphylococcus aureus is the most common cause of acute hematogenous osteoarticular infections (AHOAIs) in children. The risk factors for the development of orthopedic complications (OC) after AHOAI are poorly understood. We sought to describe clinical and microbiologic variables present on the index admission which may predict OC in S. Read More

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http://dx.doi.org/10.1093/cid/ciz109DOI Listing
February 2019
1 Read

Highly Sensitive Molecular Assay for Group A Streptococci Over-Identifies Carriers and May Impact Outpatient Antimicrobial Stewardship.

Pediatr Infect Dis J 2019 Feb 6. Epub 2019 Feb 6.

Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago.

Background: Timely, accurate diagnosis of streptococcal (GAS) pharyngitis prevents ARF and limits antibiotic overuse. The Illumigene® Group A Streptococcus assay (Meridian Bioscience) is a molecular test for GAS pharyngitis with high sensitivity and specificity. We sought to determine whether the Illumigene test is more likely than throat culture to be positive in patients without pharyngeal symptoms and explore the limits of detection of the test. Read More

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http://dx.doi.org/10.1097/INF.0000000000002293DOI Listing
February 2019

A Rare Case of Bartonella Encephalitis With Hemiplegia.

Child Neurol Open 2019 31;6:2329048X19826480. Epub 2019 Jan 31.

McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.

The authors describe a 12-year-old girl with an atypical presentation of encephalitis. She presented with fever and altered mental status and developed flaccid paralysis of her left upper extremity a day later. An electroencephalogram showed slowing over her right hemisphere. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X19826480
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http://dx.doi.org/10.1177/2329048X19826480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360466PMC
January 2019
3 Reads

Evaluation of hearing in pediatric familial Mediterranean fever patients during attack period and attack-free period.

Int J Pediatr Otorhinolaryngol 2019 Feb 1;119:185-192. Epub 2019 Feb 1.

Department of Pediatrics, Division of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, 06100, Sihhiye, Ankara, Turkey.

Objectives: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. It usually has a childhood onset and is characterized with recurrent attacks with irregular intervals. Few studies have been performed to investigate hearing in FMF patients ran with various tests and showed different results. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.042DOI Listing
February 2019
1 Read

Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

Pediatr Blood Cancer 2019 Feb 10:e27654. Epub 2019 Feb 10.

Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.

Background: Data on piperacillin-tazobactam pharmacokinetics and optimal dosing in children with cancer and fever are limited. Our objective was to investigate piperacillin pharmacokinetics and the probability of target attainment (PTA) with standard intermittent administration (IA), and to simulate PTA in other dosing regimens.

Procedure: This prospective pharmacokinetic study was conducted from April 2016 to January 2018. Read More

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http://dx.doi.org/10.1002/pbc.27654DOI Listing
February 2019
1 Read

A case of anhidrotic ectodermal dysplasia presenting with pyrexia, atopic eczema, and food allergy.

Asia Pac Allergy 2019 Jan 14;9(1):e3. Epub 2019 Jan 14.

Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan.

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365661PMC
January 2019
1 Read

Clinical spectrum of -related epileptic disorders.

Neurology 2019 Feb 8. Epub 2019 Feb 8.

From the University of Tübingen (S. Wolking, J.M., Y.G.W., H.L., J.S.), Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, Tübingen, Germany; Luxembourg Centre for Systems Biomedicine (P.M.), University of Luxembourg, Esch-sur-Alzette; Pediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G., C.M.), Children's Hospital Anna Meyer, University of Florence, Italy; Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Services (R.S.M.), University of Southern Denmark, Odense; Department of Clinical and Experimental Epilepsy (S.B.), UCL Institute of Neurology and Epilepsy Society, UK, London; Division of Neurology (K.L.H., I.H.), Children's Hospital of Philadelphia, PA; Department of Pediatric Neurology (C.D.A.), Centre de Compétences Maladies Rares, CHU Besançon; Service de Génétique (N.C.), Hospices Civils des Lyon, Bron; GENDEV Team (N.C.), Neurosciences Research Center of Lyon, Bron, France; Neuropediatric Clinic and Clinic for Neurorehabilitation (K.S.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Beaumont Hospital (P.W.-W.), Dublin, Ireland; Department of Pediatrics, Division of Medical Genetics, Institute of Human Genetics (B.A.M.), Departments of Neurology and Pediatrics (A.N.), and Departments of Neurology and Pediatrics, and Institute of Human Genetics (M.R.C.), University of California, San Francisco; Department of Neurology (W.V.P.), University Hospitals Leuven, Belgium; Department of Pediatrics (L.L.S.), Hvidovre Hospital, Denmark; King's College Hospital (S.O., E.H., S.G., D.K.P.), London; Evelina London Children's Hospital (S.O., E.H., S.G.), London, UK; Section of Genetics (K.B., M.S.S.), Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora; Clinique Bernoise Montana (T.D.), Crans-Montana, Switzerland; Department of Neuropediatrics (H.M.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics (A.T.P., S.J.L.K., J.C.T.) and Department of Oncology (D.V.V.), University of Oxford, UK; Epilepsy Center (M.P.C.), Health Sciences Department, San Paolo Hospital, University of Milan; Child Neuropsychiatry (F.D.), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Italy; Departments of Neurology and Clinical Genomics (R.H.G.) and Health Sciences Research and Clinical Genomics (E.W.K., C.K.), Mayo Clinic, Rochester, MN; Ambry Genetics (Z.P.), Aliso Viejo, CA; Department of Clinical Neuroscience (S.T.), King's College London; New Medicines (M.A., D.M.), UCB Pharma, Slough, UK; Neuropediatric Clinic and Clinic for Neurorehabilitation (G.J.K.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Research Institute for Rehabilitation, Transition and Palliation (G.J.K.), PMU Salzburg, Austria; Department of Neurology (D.H.L.), University of California, San Francisco; Neurogenetics Group (S. Weckhuysen), Center for Molecular Neurology, VIB, Antwerp; Laboratory of Neurogenetics (S. Weckhuysen), Institute Born-Bunge, University of Antwerp; Department of Neurology (S. Weckhuysen), Antwerp University Hospital, Antwerp, Belgium; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (D.K.P.), MRC Centre for Neurodevelopmental Disorders (D.K.P.), King's College London, UK; Evelina London Children's Hospital (D.K.P.), London, UK; Department of Neuropediatrics (I.H.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; Institute of Neuroscience (R.H.T.), Henry Wellcome Building, Newcastle University; Neurology Research Group (M.I.R.), Institute of Life Science, Swansea University Medical School, Swansea, UK; Service de Génétique (G.L.), Hospices Civils des Lyon, Bron; GENDEV Team (G.L.), Neurosciences Research Center of Lyon, Bron, France; NIHR University College London Hospitals Biomedical Research Centre (S.M.S.), UCL Institute of Neurology, London, UK; Cologne Center for Genomics (D.L.), University of Cologne, Germany; Stanley Center for Psychiatric Research (D.L.) and Program in Medical and Population Genetics (D.L.), Broad Institute of MIT and Harvard, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit (D.L.), Massachusetts General Hospital and Harvard Medical School, Boston.

Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to , encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants.

Methods: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007089DOI Listing
February 2019
1 Read

Serological and molecular detection of Bartonella henselae in specimens from patients with suspected cat scratch disease in Italy: A comparative study.

PLoS One 2019 8;14(2):e0211945. Epub 2019 Feb 8.

Microbiology section, Department of Public Health and Pediatrics, University of Torino, Turin, Italy.

Cat scratch disease (CSD) is an infectious disease caused by Bartonella henselae, usually characterized by self-limiting regional lymphadenopathy and fever. Given the low clinical diagnostic sensitivity and specificity of conventional anti-B. henselae indirect immunofluorescence assays (IFAs), real-time polymerase chain reaction (PCR)-based detection of B. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211945PLOS
February 2019
3 Reads

Immunogenicity and side-effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients.

Pediatr Int 2019 Jan;61(1):104-106

Second Department of Paediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.

The aim of this study was to compare the immunogenicity and side-effects of hepatitis A virus (HAV) vaccination between periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) patients and healthy controls who have not been previously exposed to HAV. A prospective observational study was carried out of 28 PFAPA patients and 76 controls who received two doses of the vaccine. Immunogenicity was expressed as seroconversion and seroprotection rates; mean HAV-immunoglobulin G concentration was measured at 0, 1, 7 and 18 months. Read More

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http://dx.doi.org/10.1111/ped.13719DOI Listing
January 2019
1 Read

Pediatric non-Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand.

Pediatr Int 2019 Jan;61(1):49-57

Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: In the modern era of chemotherapy, the outcome of pediatric non-Hodgkin lymphoma (NHL) continues to improve internationally. Limited data such as information on epidemiology and survival, however, are available in Asian countries.

Methods: Children (≤15 years old) diagnosed with histologically proven NHL from 1998 to 2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1111/ped.13739DOI Listing
January 2019
1 Read

Pyogenic sacroiliitis in children: don't forget the very young.

Eur J Pediatr 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Mount Scopus Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.

Pyogenic sacroiliitis (PS) is rare with less than 100 pediatric cases reported in the medical literature. To better characterize PS in the pediatric population, we investigated a series of children presenting with PS. Retrospective data analysis was done at an academic tertiary center between the years of 2000 and 2017. Read More

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http://dx.doi.org/10.1007/s00431-019-03333-8DOI Listing
February 2019
2 Reads

Safety and immunogenicity of a varicella vaccine without human serum albumin (HSA) versus a HSA-containing formulation administered in the second year of life: a phase III, double-blind, randomized study.

BMC Pediatr 2019 Feb 7;19(1):50. Epub 2019 Feb 7.

GSK, Avenue Fleming 20, B-1300, Wavre, Belgium.

Background: A new formulation of the live-attenuated varicella vaccine Varilrix (GSK) produced without human serum albumin (HSA) was developed to minimize a theoretical risk of transmission of infectious diseases. A previous study showed that the vaccine was immunologically non-inferior to the HSA-containing vaccine and well-tolerated in toddlers; low-grade fever was numerically higher in children receiving the vaccine without HSA, but the study lacked power to conclude on this difference.

Methods: In this phase III, double-blind, multi-center study, healthy 12-23-month-olds were randomized (1:1) to receive two doses of the varicella vaccine without (Var-HSA group) or with HSA (Var + HSA group) at days 0 and 42. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1425-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366055PMC
February 2019
13 Reads

Glucagon-like peptide-1 is a marker of systemic inflammation in patients treated with high-dose chemotherapy and autologous stem cell transplantation.

Biol Blood Marrow Transplant 2019 Feb 4. Epub 2019 Feb 4.

Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark; Institute for Inflammation Research, University Hospital Rigshospitalet, Copenhagen, Denmark.

Autologous stem cell transplantation (ASCT) is challenged by side effects that may be propagated by chemotherapy-induced mucositis resulting in bacterial translocation and systemic inflammation. Since gastrointestinal damage appear as an early event in this cascade of reactions, we hypothesized that markers reflecting damage to the intestinal barrier could serve as early predictive markers of toxicity. Glucagon-like peptide-1 (GLP-1), a well-known regulator of blood glucose, has been found to promote intestinal growth and repair in animal studies. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.01.036DOI Listing
February 2019

Early-Onset Neonatal Meningitis Caused by an Unusual Pathogen-.

Case Rep Pediatr 2019 9;2019:4740504. Epub 2019 Jan 9.

Professor and Head, Department of Microbiology, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Introduction: are part of the normal flora of the human respiratory tract and are known to have low pathogenic potential. The organism is rarely reported in the literature as the causative agent of meningitis. We report the first case of early-onset neonatal meningitis associated with from Nepal. Read More

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http://dx.doi.org/10.1155/2019/4740504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343129PMC
January 2019
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Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis.

Emerg Med J 2019 Feb 6. Epub 2019 Feb 6.

Division of Pediatric Emergency Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants <1 month old with bronchiolitis often receive a lumbar puncture (LP), despite limited data for this practice and lack of clinical practice guidelines for this population. The primary objective was to investigate practice patterns in performance of LPs in the ED management of febrile infants aged ≤30 days with bronchiolitis. Read More

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http://dx.doi.org/10.1136/emermed-2018-208000DOI Listing
February 2019
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Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.

Cell Rep 2019 Feb;26(6):1585-1597.e4

Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.052DOI Listing
February 2019
2 Reads

Five-day fever · elevated creatinine levels · kidney transplant 10 months prior · Dx?

J Fam Pract 2019 Jan/Feb;68(1):E12-E14

Department of Internal Medicine and Department of Pediatrics, Los Angeles County + University of Southern California Medical Center, Los Angeles, CA.

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February 2019

Nonneutropenic fever in children with cancer: A scoping review of management and outcome.

Pediatr Blood Cancer 2019 Feb 5:e27634. Epub 2019 Feb 5.

The Paediatric Integrated Cancer Service, Parkville, Victoria, Australia.

To date, very few studies have addressed nonneutropenic fever (NNF) in children with cancer, and there are no consensus guidelines. This scoping review aims to describe the rate of bacteremia, risk factors for infection and management, and outcomes of NNF in this population. Across 15 studies (n = 4106 episodes), the pooled-average bacteremia rate was 8. Read More

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http://dx.doi.org/10.1002/pbc.27634DOI Listing
February 2019

Detection of epidemic scarlet fever group A Streptococcus in Australia.

Clin Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Sentinel hospital surveillance was instituted in Australia to detect the presence of pandemic group A Streptococcus strains causing scarlet fever. Genomic and phylogenetic analyses indicated the presence of an Australian GAS emm12 scarlet fever isolate related to UK outbreak strains. National surveillance to monitor this pandemic is recommended. Read More

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http://dx.doi.org/10.1093/cid/ciz099DOI Listing
February 2019

A Toddler With Prolonged Fever and Intermittent Cough.

Glob Pediatr Health 2019 23;6:2333794X18822999. Epub 2019 Jan 23.

Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Fever of unknown origin is an important diagnostic challenge in pediatrics that requires a thoughtful approach. The differential diagnosis is broad and includes infectious, autoimmune, oncologic, neurologic, genetic, and iatrogenic causes. Infection remains the most common etiology, and uncommon presentations of infections are still more likely than classic presentations of rare conditions. Read More

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http://dx.doi.org/10.1177/2333794X18822999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348535PMC
January 2019
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Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children.

J Infect Chemother 2019 Feb 1. Epub 2019 Feb 1.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan; Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Japan.

Background: Mycoplasma pneumoniae pneumonia (MPP) is generally a self-limiting disease, but it may become refractory. It is thought that refractory MPP is linked to the excessive immunologic responses of the host. Consequently, the use of adjunctive systemic corticosteroids may have beneficial effects. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.003DOI Listing
February 2019
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Systematic review finds that fever phobia is a worldwide issue among caregivers and healthcare providers.

Acta Paediatr 2019 Feb 4. Epub 2019 Feb 4.

Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Aim: Fever phobia describes exaggerated concerns about the consequences of childhood fever and broader awareness is needed in everyday clinical practice. We investigated the factors associated with fever phobia in caregivers and healthcare providers and the geographical distribution of the issue.

Methods: The National Library of Medicine and Excerpta Medica databases were searched for papers on fever phobia, excluding those that tackled fever phobia. Read More

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http://dx.doi.org/10.1111/apa.14739DOI Listing
February 2019
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Acute rheumatic fever: A neglected diagnosis in Greece.

Hellenic J Cardiol 2019 Jan 31. Epub 2019 Jan 31.

Department of Paediatrics, "Karamandaneion"General Paediatric Hospital Patras.

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http://dx.doi.org/10.1016/j.hjc.2019.01.013DOI Listing
January 2019
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Lymph-node-first Kawasaki disease and giant coronary artery aneurysm.

Authors:
Bazlin Ramly

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Paediatric Department, University Hospital Waterford, Waterford, Ireland.

A 8-year-old Irish ethnicity girl presented with 3 days of fever with right-sided neck swelling which was first thought as acute tonsillitis with right-sided lymphadenitis. She was started on intravenous antibiotics. At day 7 of illness, she was diagnosed to have Kawasaki disease with clinical and biochemical evidence. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22689
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http://dx.doi.org/10.1136/bcr-2018-226897DOI Listing
February 2019
5 Reads

Virus load and clinical features during the acute phase of Chikungunya infection in children.

PLoS One 2019 1;14(2):e0211036. Epub 2019 Feb 1.

Department of Biotechnology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India.

Background: Chikungunya virus (CHIKV) infection is a long known mosquito-borne disease that is associated with severe morbidity, characterized by fever, headache, rashes, joint pain, and myalgia. It is believed that virus load has relation with severity of clinical features.

Objectives: We performed this study to assess the relationship between virus load and clinical features in children during the acute phase of CHIKV infection, in order to draw insights for better-informed treatment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211036PLOS
February 2019

Frequency of functional gastrointestinal disorders in children with familial Mediterranean fever.

Clin Rheumatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Saricam, 01331, Adana, Turkey.

Introduction: Familial Mediterranean fever (FMF) is characterized by self-limiting fever episodes usually accompanied by serositis, arthralgia, and arthritis. Functional gastrointestinal disorders (FGIDs) are diseases in which brain-gut axis and low-grade inflammation take part in pathogenesis. We aimed to study the FGIDs frequencies and possible risk factors for FGIDs in children with FMF. Read More

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http://dx.doi.org/10.1007/s10067-019-04452-1DOI Listing
January 2019
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Group A streptococcus endocarditis in children: 2 cases and a review of the literature.

BMC Infect Dis 2019 Jan 31;19(1):102. Epub 2019 Jan 31.

Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Department of General Pediatrics, Okinawa, Japan.

Background: Infective endocarditis (IE) is defined as endocarditis caused by microorganisms (bacteria or fungi) involving either the heart or great vessels. The clinical course of IE can be complicated by cardiac dysfunction and bacterial embolization to virtually any organ. Staphylococcus aureus and viridans group streptococci are the most common causative organisms, whereas group A Streptococcus (GAS) is less common. Read More

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http://dx.doi.org/10.1186/s12879-019-3736-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357504PMC
January 2019
2 Reads

Round pneumonia due to in a child.

Radiol Case Rep 2019 Apr 18;14(4):436-438. Epub 2019 Jan 18.

Department of Pediatrics, National Hospital Organization Saitama National Hospital, Saitama, Japan.

Round pneumonia is a disease commonly recognized in the pediatric age group, especially under the age of 8 years. is the most common agent causing this characteristic type of pneumonia. We herein report a case of a 6-year-old boy with only mild cough and low-grade fever who was then diagnosed with round pneumonia due to . Read More

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http://dx.doi.org/10.1016/j.radcr.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348194PMC
April 2019
2 Reads

An open-label, randomized prospective study to evaluate the efficacy and safety of leaf extract for thrombocytopenia associated with dengue fever in pediatric subjects.

Pediatric Health Med Ther 2019 17;10:5-11. Epub 2019 Jan 17.

Department of Medical Services, Micro Labs Ltd, Bengaluru, Karnataka, India.

Objective: Thrombocytopenia in dengue fever (DF) is a well-known complication in both adults and pediatric subjects. Management of DF primarily includes symptomatic and intensive supportive care. There are studies available on the efficacy and safety of leaf extract (CPLE) in adult patients with DF. Read More

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http://dx.doi.org/10.2147/PHMT.S176712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340360PMC
January 2019

Neurodevelopmental Impairments 1 Year After Cerebral Malaria.

Pediatrics 2019 Jan 29. Epub 2019 Jan 29.

Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.

: media-1vid110.1542/5972295739001PEDS-VA_2018-1026 BACKGROUND AND OBJECTIVES: Cerebral malaria (CM) causes significant mortality and morbidity in sub-Saharan African children. Reliable morbidity estimates are scarce because of methodological variability across studies. Read More

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http://dx.doi.org/10.1542/peds.2018-1026DOI Listing
January 2019
5.473 Impact Factor

Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal.

BMC Pediatr 2019 Jan 29;19(1):36. Epub 2019 Jan 29.

Department of Microbiology and Infectious Diseases, B. P. Koirala Institute of Health Sciences, Dharan, Sunsari, 56700, Nepal.

Background: Urinary tract infection (UTI) is one of most common pediatric infections. The study was designed to assess the clinical profile, common bacterial microorganisms causing UTI and their antimicrobial susceptibility patterns at B. P. Read More

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http://dx.doi.org/10.1186/s12887-019-1410-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350346PMC
January 2019
1 Read