13,965 results match your criteria Pediatrics Fever


Serum sodium level is inversely correlated with body temperature in children.

Pediatr Int 2021 May 15. Epub 2021 May 15.

Department of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

Background: Several studies have demonstrated that non-osmotic antidiuretic hormone activity contributes to the development of hyponatremia in children with common febrile diseases. However the relationship between hyponatremia and body temperature has remained unclear. Therefore, we examined this relationship in children with common diseases. Read More

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Factors associated with complicated pneumonia in children.

Pediatr Pulmonol 2021 May 15. Epub 2021 May 15.

Pediatric Pulmonary Institute and CF Center, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Introduction: CAP (community acquired pneumonia) is a leading cause of morbidity in children, despite advances in healthcare and anti-pneumococcal vaccine. Complicated pneumonia accounts for a significant burden with prolonged hospitalization. Finding risk factors for complicated pneumonia may help in tailoring management. Read More

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Case Report: Resection of Giant Endotracheal Hamartoma by Electrosurgical Snaring via Fiberoptic Bronchoscopy in a 9-Year-Old Boy.

Front Pediatr 2021 27;9:528966. Epub 2021 Apr 27.

Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Endotracheal hamartomas are rarely encountered in children. The symptoms of endotracheal hamartoma may include cough, dyspnea, hemoptysis, chest pain, purulent sputum, and fever. The non-specific symptoms often result in a delayed diagnosis. Read More

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Successful laparoscopic resection of ovarian abscess caused by Staphylococcus aureus in a 13-year-old girl: a case report and review of literature.

BMC Womens Health 2021 May 13;21(1):198. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan.

Background: Ovarian abscesses, which occur mostly in sexually active women via recurrent salpingitis, occur rarely in virginal adolescent girls. Here, we present a case of an ovarian abscess in a virginal adolescent girl who was diagnosed and treated by laparoscopy.

Case Presentation: A 13-year-old healthy girl presented with fever lasting for a month without abdominal pain. Read More

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A prediction model of risk factors for complications among SARS-CoV2 positive patients: Cases from Jordan.

J Infect Public Health 2021 Mar 6;14(6):689-695. Epub 2021 Mar 6.

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.

Background: The number of COVID-19 infected patients has been soaring in the Middle East countries. The disease poses a significant threat, decisions about prioritizing care should be made in accordance with the proven risk factors for complications.

Objective: The present study provides the first bespoke prediction model in the Middle East to identify COVID-19 patients, who are at higher risk for complications. Read More

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An investment case for the prevention and management of rheumatic heart disease in the African Union 2021-30: a modelling study.

Lancet Glob Health 2021 May 10. Epub 2021 May 10.

Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA; Program in Global Noncommunicable Disease and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA; Partners In Health, Boston, MA, USA. Electronic address:

Background: Despite declines in deaths from rheumatic heart disease (RHD) in Africa over the past 30 years, it remains a major cause of cardiovascular morbidity and mortality on the continent. We present an investment case for interventions to prevent and manage RHD in the African Union (AU).

Methods: We created a cohort state-transition model to estimate key outcomes in the disease process, including cases of pharyngitis from group A streptococcus, episodes of acute rheumatic fever (ARF), cases of RHD, heart failure, and deaths. Read More

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Molecular Epidemiology and Clinical Features of Enteroviruses-Associated Hand, Foot, and Mouth Disease and Herpangina Outbreak in Zunyi, China, 2019.

Front Med (Lausanne) 2021 26;8:656699. Epub 2021 Apr 26.

Department of Clinical Laboratory, Zunyi Medical University Third Affiliated Hospital, Zunyi, China.

Hand, foot and mouth disease (HFMD) and herpangina (HA), two of the most common childhood infectious diseases, are associated with enteroviruses (EVs) infection. The aim of this study was to identify the molecular epidemiology of enterovirus causing HFMD/HA in Zunyi, China, during 2019, and to describe the clinical features of the cases. We collected the information on demographic and clinical characteristics, laboratory data of laboratory-confirmed EVs associated HFMD/HA cases in Zunyi Medical University Third Affiliated Hospital between March 1 and July 31, 2019. Read More

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Giant intracardiac thrombosis in an infant with leukaemia and prolonged COVID-19 viral RNA shedding: a case report.

Thromb J 2021 May 12;19(1):31. Epub 2021 May 12.

Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Children's Medical Center Hospital, Dr. Gharib Street, Keshavarz Boulevard, Tehran, Iran.

Background: COVID-19 can induce thrombotic disease both in the venous and arterial circulations, as a result of inflammation, platelet activation, endothelial dysfunction, and stasis. Although several studies have described the coagulation abnormalities and thrombosis in adult patients with COVID-19, there is limited data in children. Here, we present an 18-month-old boy with a prolonged SARS-CoV-2 RNA shedding and chronic right atrial and superior vena cava (SVC) thrombosis. Read More

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Prevalence of Bacterial Meningitis Among Febrile Infants Aged 29-60 Days With Positive Urinalysis Results: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 May 3;4(5):e214544. Epub 2021 May 3.

Division of Pediatric Emergency Medicine, Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

Importance: Fever in the first months of life remains one of the most common pediatric problems. Urinary tract infections are the most frequent serious bacterial infections in this population. All published guidelines and quality initiatives for febrile young infants recommend lumbar puncture (LP) and cerebrospinal fluid (CSF) testing on the basis of a positive urinalysis result to exclude bacterial meningitis as a cause. Read More

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Delayed-Onset ADA1 (ADA) Deficiency Not Detected by TREC Screen.

Pediatrics 2021 May 11. Epub 2021 May 11.

Division of Allergy and Immunology, Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus, Ohio; and.

A 9-month-old boy presented to a community pediatrician with a recent history of failure to thrive. Workup revealed neutropenia and lymphopenia. Subsequent admission for fever and pneumonia revealed an absolute neutrophil count of 860 and absolute lymphocyte count of 214. Read More

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Pediatric liver and kidney transplantation in the era of COVID-19: a follow-up study from a tertiary referral center in Iran.

BMC Surg 2021 May 11;21(1):240. Epub 2021 May 11.

Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: We aimed to evaluate the impact of COVID-19 pandemic on pediatric transplant outcomes and determine whether to continue pediatric transplant activity or not, and how policies intended our center has been effective in preventing COVID-19 among organ transplant recipients.

Methods: We conducted a single-center, retrospective, cohort study of hospitalized pediatrics after organ transplantation at Shiraz transplant center since March to August 2020. All liver and kidney transplanted children were included the study and their laboratory and clinical related COVID-19 characteristics were followed up till 3 months after transplantation during hospitalization period and then weekly by the transplant committee. Read More

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Risk Factors of Outcomes of COVID-19 Patients in Korea: Focus on Early Symptoms.

J Korean Med Sci 2021 May 10;36(18):e132. Epub 2021 May 10.

Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.

Background: Coronavirus disease 2019 (COVID-19) has spread around the globe, and it is important to determine the risk factors of death in the general population. Our study aimed to determine the risk factors of death and severe illness requiring supplemental oxygen therapy based on the demographic and clinical characteristics of COVID-19 patients in Korea.

Methods: In this study, we used data provided by the Korea Disease Control and Prevention Agency (KDCA) and analyzed a total of 5,068 patients with COVID-19, excluding 19 pregnant women and 544 individuals with missing data. Read More

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Re-thinking yellow fever vaccines: fighting old foes with new generation vaccines.

Hum Vaccin Immunother 2021 May 11:1-9. Epub 2021 May 11.

The Jenner Institute, Nuffield Department of Medicine, University of Oxford. The Henry Wellcome Building for Molecular Physiology, Oxford, UK.

Despite the existence of a highly efficient yellow fever vaccine, yellow fever reemergence throughout Africa and the Americas has put 900 million people in 47 countries at risk of contracting the disease. Although the vaccine has been key to controlling yellow fever epidemics, its live-attenuated nature comes with a range of contraindications that prompts advising against its administration to pregnant and lactating women, immunocompromised individuals, and those with hypersensitivity to chicken egg proteins. Additionally, large outbreaks have highlighted problems with insufficient vaccine supply, whereby manufacturers rely on slow traditional manufacturing processes that prevent them from ramping up production. Read More

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[Clinical and genetic analysis of a patient with Mowat-Wilson syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 May;38(5):465-468

Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, Shandong 266035, China.

Objective: To summarize the clinical phenotype and genotype of a Chinese child affected with Mowat-Wilson syndrome (MWS).

Methods: Clinical data of the patient were collected. The patient was analyzed by whole-exome sequencing (WES) as well as Sanger sequencing. Read More

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Predictors of failed enema reduction in children with intussusception: a systematic review and meta-analysis.

Eur Radiol 2021 May 11. Epub 2021 May 11.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Objective: To identify predictors of failed enema reduction in children with intussusception.

Methods: PubMed and EMBASE were searched for all studies published over a 20-year time frame, prior to March 25, 2020. Original articles that reported predictors of failed enema reduction were included. Read More

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Sodium-containing versus sodium-trace preparations of IVIG for children with Kawasaki disease in the acute phase.

Eur J Pediatr 2021 May 10. Epub 2021 May 10.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Kawasaki disease (KD) is an acute systemic vasculitis that most commonly causes acquired cardiac disease in children in developed countries. The most highly recommended treatment for KD is 2 g/kg intravenous immunoglobulin (IVIG). There are two types of IVIG, sodium-containing (high-Na) and sodium-trace (low-Na) preparations. Read More

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Pandemics throughout the centuries.

Clin Dermatol 2021 Jan-Feb;39(1):5-8. Epub 2020 Dec 17.

Departments of Dermatology, Pathology, and Pediatrics, Rutgers New Jersey Medical School, Infectious Diseases, Newark, New Jersey, USA. Electronic address:

Pandemics have ravished the globe periodically, often associated with war, at times commencing as fever and rash, beginning in recorded history in the crowded walled city of Athens during the Peloponnesian War as described in great detail by the Athenian historian and military general Thucydides in 430 BCE. As the world now faces the first major pandemic of the 21st century, we focus on the "plague" commencing in Athens in 430 BCE and the 2 pandemics of the more recent century, which killed more than one million, the Spanish flu of 1918 and the Asian flu of 1957. The latter linked with successful vaccine development thanks to the heroic efforts of microbiologist Maurice Hilleman. Read More

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December 2020

A dermatologic perspective on multisystem inflammatory syndrome in children.

Clin Dermatol 2021 Jan-Feb;39(1):163-168. Epub 2020 Sep 23.

Departments of Dermatology and Pediatrics, Columbia University Medical Center, New York, New York, USA.

As of May 2020, an emerging immune-mediated syndrome mainly affecting children has been detected primarily in Europe and the United States. The incidence of this syndrome appears to mirror the initial infectious assault, with a delay of several weeks. This syndrome has been termed "multisystem inflammatory syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019 (COVID-19). Read More

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September 2020

[Antibacterial Prophylaxis in Children and Adolescents Undergoing Therapy for Cancer - Statement of the Society of Pediatric Oncology and Hematology (GPOH) and of the German Society for Pediatric Infectious Diseases (DGPI) on Two Current International Guidelines].

Klin Padiatr 2021 May 10;233(3):101-106. Epub 2021 May 10.

Infectious Disease Research Program, Center for Bone Marrow Transplantation, Department of Pediatric Hematology/Oncology, University Children's Hospital, Muenster, Muenster, Germany.

Immunocompromised children and adolescents receiving treatment for cancer have an increased risk for potentially life-threatening infectious complications such as blood stream infections with Gram-positive and Gram-negative pathogens. Therefore, several centers for Pediatric Hematology and Oncology administer antibacterial prophylaxis to these patients to lower morbidity and mortality. Two pediatric specific guidelines on antibacterial prophylaxis were recently published. Read More

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Case Report: Granulomatous Amebic Encephalitis due to Acanthamoeba spp. in an Immunocompetent Pediatric Patient.

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

2Department of Pediatrics, Hospital Universitario "Dr. José Eleuterio González," Universidad Autonoma de Nuevo León, Monterrey, Mexico.

Granulomatous amebic encephalitis (GAE) caused by Acanthamoeba is a rare infection with central nervous system (CNS) involvement usually with fatal consequences. Currently, information regarding GAE in children is scarce and is limited only to case reports and case series. A 13-year-old immunocompetent male patient with a 6-month history of progressive and intermittent headaches presented to our institution. Read More

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Using community-led development to build health communication about rheumatic heart disease in Aboriginal children: a developmental evaluation.

Aust N Z J Public Health 2021 May 10. Epub 2021 May 10.

Menzies School of Health Research, Charles Darwin University, Northern Territory.

Objective: A high prevalence of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) among Aboriginal children in northern Australia is coupled with low understanding among families. This has negative impacts on children's health, limits opportunities for prevention and suggests that better health communication is needed.

Methods: During an RHD echocardiography screening project, Aboriginal teachers in a remote community school created lessons to teach children about RHD in their home languages, drawing on principles of community-led development. Read More

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Distinctive clinical and laboratory features of COVID-19 and H1N1 influenza infections among hospitalized pediatric patients.

World J Pediatr 2021 May 10. Epub 2021 May 10.

Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Background: It had been documented in many studies that pediatric coronavirus disease 2019 (COVID-19) is characterized by low infectivity rates, low mortalities, and benign disease course. On the other hand, influenza type A viruses are recognized to cause severe and fatal infections in children populations worldwide. This study is aimed to compare the clinical and laboratory characteristics of COVID-19 and H1N1 influenza infections. Read More

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Congenital Coccidioidomycosis: A Case Report and Review of the Literature.

J Pediatric Infect Dis Soc 2021 May 10. Epub 2021 May 10.

Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Coccidioidomycosis in neonates is rare and the acquisition of disease in this age group is not well understood. Congenital coccidioidomycosis is very rare, usually associated with coccidioidal placentitis. Only a handful of cases of congenital coccidioidomycosis have been described in the literature. Read More

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SARS-CoV-2 RNAaemia in children: An Iranian referral hospital-based study.

J Med Virol 2021 May 10. Epub 2021 May 10.

Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is generally detected in nasopharyngeal swabs, viral RNA can be found in other samples including blood. Recently, associations between SARS-CoV-2 RNAaemia and disease severity and mortality have been reported in adults, while no reports are available in pediatric patients with coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the mortality, severity, clinical, and laboratory findings of SARS-CoV-2 RNA detection in blood in 96 pediatric patients with confirmed COVID-19. Read More

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Clinical diagnosis of severe COVID-19: A derivation and validation of a prediction rule.

World J Clin Cases 2021 May;9(13):2994-3007

Shenzhen Hospital, Southern Medical University, Shenzhen 518000, Guangdong Province, China.

Background: The widespread coronavirus disease 2019 (COVID-19) has led to high morbidity and mortality. Therefore, early risk identification of critically ill patients remains crucial.

Aim: To develop predictive rules at the time of admission to identify COVID-19 patients who might require intensive care unit (ICU) care. Read More

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Acetaminophen and ibuprofen in the treatment of pediatric fever: A narrative review.

Curr Med Res Opin 2021 May 9. Epub 2021 May 9.

Department of Clinical Pharmacology, University Medical Center at Georg-August-Universität, Göttingen, Germany.

Objective: A narrative review of randomized, blinded, controlled studies assessing the antipyretic effect of ibuprofen versus acetaminophen or combined or alternating treatment in children was conducted.

Methods: Searches of the PubMed and Embase literature databases were conducted to identify relevant articles. Selected articles were limited to studies published in English that investigated OTC oral tablet and syrup formulations of acetaminophen and ibuprofen; there were no publication date limits. Read More

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Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry.

Pediatr Crit Care Med 2021 May 10. Epub 2021 May 10.

Division of Pediatric Critical Care, Department of Pediatrics, Children's Hospital of Illinois, OSF St Francis Medical Centre at Peoria, IL. Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO. Division of Pediatric Nephrology, Department of Pediatrics, University of Alabama at Birmingham, AL. Department of Anesthesia and Critical Care, Mayo Clinic, Rochester, MN. Society of Critical Care Medicine, Mount Prospect, IL. Division of Pediatric Critical Care, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA. Division of Pediatric Critical Care. Department of Pediatrics, Advocate Children's Hospital, IL. Division of Pediatric Critical Care, Department of Pediatrics. Hassenfield Children's Hospital at NYU Langone, NY. Baylor College of Medicine, Houston, TX. Division of Pediatric Critical Care, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN. Division of Pediatric Cardiology, Department of Pediatrics. Lincoln Medical and Mental Health Center, Lincoln Hospital, Bronx, NY. Division of Pediatric Critical Care, Department of Pediatrics, Beaumont Children's Hospital, Royal Oak, MI. Division of Pediatric Nephrology, Department of Pediatrics. Seattle Children's Hospital/University of Washington, Seattle Children's Hospital, Seattle, WA. Division of Pediatric Critical Care, Department of Pediatrics, University of Oklahoma College of Medicine, Oklahoma City, OK. Division of Pediatric Critical Care, Department of Pediatrics, The Children's Hospital of San Antonio, San Antonio and Baylor College of Medicine, Houston, TX.

Objectives: To compare clinical characteristics and outcomes of children admitted to the PICU for severe acute respiratory syndrome coronavirus 2-related illness with or without multisystem inflammatory syndrome in children. The secondary objective was to identify explanatory factors associated with outcome of critical illness defined by a composite index of in-hospital mortality and organ system support requirement.

Design: Retrospective cohort study. Read More

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Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Pediatrics and Adolescent Health, Rigshospitalet, Copenhagen, Denmark.

Background: Serum insulin-like growth factor 1 (sIGF-1) is an important growth factor in childhood. However, studies on sIGF-1 among children from low-income countries are few, and the role of body composition is unknown.

Objectives: To assess the associations of anthropometry, body composition, inflammation, and breastfeeding with sIGF-1 among children with moderate acute malnutrition (MAM). Read More

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The pyrin inflammasome aggravates inflammatory cell migration in patients with familial Mediterranean fever.

Pediatr Res 2021 May 7. Epub 2021 May 7.

Department of Medical Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by pathogenic variants of the MEFV gene, which encodes pyrin. Leukocyte migration to serosal sites is a key event during inflammation in FMF. The pyrin inflammasome is a multiprotein complex involved in inflammation. Read More

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