11,339 results match your criteria Pediatrics Fever


Genetic and phenotypic characteristics of SCN1A-related epilepsy in Chinese children.

Neuroreport 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Children's Hospital of Chongqing Medical University.

SCN1A gene mutations are associated with epilepsy and neurodevelopmental disorders. This study aimed to explore the genotype and phenotype spectrum of SCN1A gene related epilepsy. Epileptic patients who were treated in the Children's Hospital of Chongqing Medical University from January 2015 to July 2018 and identified as having SCN1A mutations by targeted next-generation sequencing were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNR.0000000000001259DOI Listing

Postvaccination Fever Response Rates in Children Derived Using the Fever Coach Mobile App: A Retrospective Observational Study.

JMIR Mhealth Uhealth 2019 Apr 22;7(4):e12223. Epub 2019 Apr 22.

Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Postvaccination fever is a mild adverse event that naturally improves without complications, but is highly prevalent and can be accompanied by febrile convulsions in some cases. These adverse effects may cause parents to delay or avoid vaccinating their children.

Objective: This study aimed to identify postvaccination fever patterns and the ability of antipyretics to affect changes in these patterns from data collected from a mobile app named Fever Coach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/12223DOI Listing

[Macrophage activation syndrome revealing subcutaneous T-cell lymphoma in a 16-year old adolescent].

Pan Afr Med J 2018 2;31:74. Epub 2018 Oct 2.

Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah, Service de Pédiatrie CHU Hassan II, Fès, Maroc.

Macrophage activation syndrome (MAS) is a multisystemic disorder resulting from an over-activation of the immune system leading to a more or less diffuse macrophagic infiltration into the tussues. Clinical signs including fever, hepatosplenomegaly, adenopathy are associated with abnormal values in laboratory test results (bi or pancytopenia, hepatic cytolysis, elevated LDH levels, coagulopathy) and hemophagocytosis. In children, it can be primary or secondary to several disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2018.31.74.14686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457733PMC
October 2018

Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Paediatric Rheumatology and Immunology, University of Münster, Münster, Germany

Objectives: The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a 'window of opportunity' to abrogate the development of chronic arthritis. Read More

View Article

Download full-text PDF

Source
http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21505
Publisher Site
http://dx.doi.org/10.1136/annrheumdis-2019-215051DOI Listing
April 2019
1 Read

Anterior cingulate cortex involvement in non-paraneoplastic limbic encephalitis.

Brain Dev 2019 Apr 17. Epub 2019 Apr 17.

Department of Pediatrics, Asahi General Hospital, Chiba, Japan.

Background: Non-paraneoplastic limbic encephalitis is characterized by attention deficit, loss of emotion control, and impaired memory. Viral infection can cause acute encephalitis in children, occasionally exhibiting clinical features of limbic dysfunction. However, how viral infection affects the limbic system remains to be elucidated. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03877604183052
Publisher Site
http://dx.doi.org/10.1016/j.braindev.2019.04.006DOI Listing

Abdominal Lymphoma Presenting as Terminal Ileitis: A Case Report.

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Most pediatric patients with lymphoma do not have classic symptoms of fever, night sweats, and weight loss. Lymphoma can present as vague symptoms and may mimic common pediatric abdominal emergencies. In this case report, we present a child who presented with abdominal pain and who was initially misdiagnosed as having a surgical emergency. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07364679193013
Publisher Site
http://dx.doi.org/10.1016/j.jemermed.2019.03.004DOI Listing
April 2019
2 Reads

Long-Term Retention Rate of Anakinra in Adult Onset Still's Disease and Predictive Factors for Treatment Response.

Front Pharmacol 2019 2;10:296. Epub 2019 Apr 2.

Research Centre of Systemic Autoinflammatory Diseases, Behçet's Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Anakinra (ANA) is an effective treatment choice in patients with adult onset Still's disease (AOSD). Variables affecting treatment survival include loss of efficacy or adverse events, but also the decision to discontinue treatment after long-term clinical remission. Aims of this study were: (i) to assess the drug retention rate (DRR) of ANA during a long-term follow-up looking for any difference related to the line of biologic treatment, the concomitant use of conventional disease modifying anti-rheumatic drugs (cDMARDs) and the different type of AOSD (systemic versus chronic articular); (ii) to identify predictive factors of lack of efficacy, loss of efficacy, and ANA withdrawal owing to long-term remission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454864PMC

Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review.

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

View Article

Download full-text PDF

Source
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3963-xDOI Listing
April 2019
1 Read

Kikuchi-Fujimoto Disease: An Atypical Presentation of a Rare Disease.

Cureus 2019 Feb 1;11(2):e3999. Epub 2019 Feb 1.

Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Kikuchi-Fujimoto disease (KFD), or necrotizing histiocytic lymphadenitis, is a rare cause of lymphadenopathy and fever. Although the clinical course is usually benign, KFD is often mistaken for malignancy or infection. Recognition of typical and atypical cases of KFD is necessary to avoid unnecessary interventions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445562PMC
February 2019
2 Reads

Increased Incidence of Kawasaki Disease in Taiwan in Recent Years: A 15 Years Nationwide Population-Based Cohort Study.

Front Pediatr 2019 29;7:121. Epub 2019 Mar 29.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Kawasaki disease (KD) is diagnosed in children suffering from fever for more than five days and five clinical characteristic symptoms. The aim of this article was to research the clinical characteristics among KD children in Taiwan in recent years through a population-based cohort study. We carried out a nationwide retrospective cohort study by analyzing the data of KD patients (ICD-9-CM code 4461) from Taiwan's National Health Insurance Research Database (NHIRD) during the period of 1996-2011. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2019.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450208PMC

Febrile seizures with leukocytosis as a predictor for occult bacteremia.

Pediatr Int 2019 Apr 12. Epub 2019 Apr 12.

Division of Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, JPN.

Background: Febrile children 3-36 months old, who had a body temperature > 39 °C and white blood cell count > 15,000/mm were known to be at risk for occult pneumococcal bacteremia (OPB) in the pre-pneumococcal conjugate vaccine (PCV) era. However, the positive predictive value of this criteria decreased dramatically after introduction of PCV, which indicates a need for alternative criteria. Previous studies demonstrated a high rate of febrile seizures in children with OPB, suggesting that screening may still be practical in this population. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.13862
Publisher Site
http://dx.doi.org/10.1111/ped.13862DOI Listing
April 2019
1 Read

Identification of influenza C virus in young South Korean children, from October 2013 to September 2016.

J Clin Virol 2019 Mar 27;115:47-52. Epub 2019 Mar 27.

Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Asia Pacific Influenza Institute, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Background: Influenza C virus has been largely neglected, compared to influenza A orB viruses, and is not routinely tested in clinical practices. However, several studies have indicated that influenza C virus causes severe acute respiratory illness and pneumonia in all ages.

Objective: We conducted a study to identify influenza C virus among young children in South Korea. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13866532193007
Publisher Site
http://dx.doi.org/10.1016/j.jcv.2019.03.016DOI Listing
March 2019
5 Reads

A rare case of osteomyelitis of the clavicle in a child due to Group A streptococcal infection.

BMJ Case Rep 2019 Apr 11;12(4). Epub 2019 Apr 11.

Paediatrics, University Hospitals of Leicester, Leicester, UK.

Acute osteomyelitis of the clavicle is rare in the paediatric age group. We treated a 5-year-old boy who presented initially with fever and left shoulder pain, and subsequently developed swelling in the region of the left clavicle. Group A (GAS) was isolated in blood culture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227090DOI Listing
April 2019
1 Read

A systematic review of necrotising fasciitis in children from its first description in 1930 to 2018.

BMC Infect Dis 2019 Apr 11;19(1):317. Epub 2019 Apr 11.

Department of Paediatric Surgery, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, 26 Chris Hani Road, Johannesburg, ZA-1860, South Africa.

Background: Necrotising fasciitis is a rapidly progressing soft-tissue infection with a low incidence that carries a relevant risk of morbidity and mortality. Although necrotising fasciitis is often fatal in adults, its case fatality rate seems to be lower in children. A highly variable clinical presentation makes the diagnosis challenging, which often results in misdiagnosis and time-delay to therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-3941-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458701PMC
April 2019
1 Read

Early Blood Biomarkers to Improve Sepsis/Bacteremia Diagnostics in Pediatric Emergency Settings.

Medicina (Kaunas) 2019 Apr 10;55(4). Epub 2019 Apr 10.

Lithuanian University of Health Sciences, Medical Academy, 44307 Kaunas, Lithuania.

Sepsis is the leading cause of death in children worldwide. Early recognition and treatment are essential for preventing progression to lethal outcomes. CRP and Complete Blood Count (CBC) are the initial preferred tests to distinguish between bacterial and viral infections. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/1010-660X/55/4/99
Publisher Site
http://dx.doi.org/10.3390/medicina55040099DOI Listing
April 2019
4 Reads

Development of an RT-LAMP assay for the detection of Lassa viruses in southeast and south-central Nigeria.

J Virol Methods 2019 Apr 8;269:30-37. Epub 2019 Apr 8.

Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan; Graduate School of Biomedical Sciences and Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan. Electronic address:

Lassa virus (LASV) causes Lassa fever (LF), a viral hemorrhagic fever endemic in West Africa. LASV strains are clustered into six lineages according to their geographic location. To confirm a diagnosis of LF, a laboratory test is required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jviromet.2019.04.010DOI Listing
April 2019
1 Read

Case report: A retrospective serological analysis indicating human exposure to tick-borne relapsing fever spirochetes in Sonora, Mexico.

PLoS Negl Trop Dis 2019 Apr 11;13(4):e0007215. Epub 2019 Apr 11.

Laboratorio de Genética Microbiana, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de Mexico, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0007215DOI Listing
April 2019
1 Read

Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis.

Pharmacogenomics J 2019 Apr 11. Epub 2019 Apr 11.

Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.

Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) treatment effectively attenuates the fever and systemic inflammation. However, 10-20% patients are unresponsive to IVIG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41397-019-0085-1DOI Listing
April 2019
1 Read
4.229 Impact Factor

Hematopoietic stem cell transplantation in children with Griscelli Syndrome type 2: Experience and outcomes.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):279-282

Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.

Griscelli syndrome is a rare autosomal recessive inherited disorder characterized by hypopigmentation, silver colored hair, and associated immunological deficiency, which proves fatal in the absence of timely intervention. Our patients diagnosed with Griscelli syndrome-2 presented with fever, hepatosplenomegaly, and deranged hematological and biochemical parameters. Both cases underwent detailed investigations comprising of hair mount microscopic examination, degranulation assay, and mutational studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_645_18DOI Listing
April 2019
1 Read

Frenotomy for tongue-tie (frenulum linguae breve) showed improved symptoms in the short and long term follow-up.

Acta Paediatr 2019 Apr 10. Epub 2019 Apr 10.

Clinic for Pediatrics I, Medical University of Innsbruck, Austria.

Aim: To evaluate clinical manifestations of tongue-tie as well as short-term and long-term outcomes following frenotomy.

Methods: In this retrospective study, for 329 patients (295 infants and 34 children) who underwent frenotomy between 2011 and 2017, symptoms, short-term and long-term outcomes were evaluated.

Results: Of the 295 infants (median age 6 weeks), 199 (= 60%) showed inadequate breastfeeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.14811DOI Listing
April 2019
1 Read

Prolonged PR interval in a patient with acute rheumatic fever.

QJM 2019 Apr 9. Epub 2019 Apr 9.

Division of Cardiology, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center 2-8-29 Musashidai, Fuchu, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/qjmed/hcz082DOI Listing
April 2019
1 Read

Rubella (German measles) revisited.

Hong Kong Med J 2019 Apr 10;25(2):134-141. Epub 2019 Apr 10.

Department of Pediatric Institute, Kuala Lumpur General Hospital, Malaysia.

Rubella is generally a mild and self-limited disease in children. During pregnancy, rubella can have potentially devastating effects on the developing fetus. Postnatal rubella is transmitted primarily by inhalation of virus-laden airborne droplets or direct contact with infected nasopharyngeal secretions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12809/hkmj187785DOI Listing
April 2019
1 Read

Rare case of a 3-year-old with skull base osteomyelitis: lessons to be learnt.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Ear, Nose and Throat Surgery, Lister Hospital, Stevenage, UK.

Skull base osteomyelitis (SBO) is a serious and rare condition most commonly seen in elderly diabetic or immunocompromised patients as a complication of otitis externa. We present the case of a previously healthy 3-year-old girl who presented to the paediatric emergency department with vomiting, fever, lethargy, headache and left-sided facial nerve palsy. The initial CT head revealed left-sided otitis media with otomastoiditis and she was managed with intravenous antibiotics and myringotomy with grommet insertion with initial improvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228026DOI Listing
April 2019
1 Read

Pathoadaptive alteration of biofilm formation in response to the gallbladder environment.

J Bacteriol 2019 Apr 8. Epub 2019 Apr 8.

Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, Ohio, USA.

Typhoid fever, a human-specific disease, is primarily caused by the pathogen serovar Typhi ( Typhi). It is estimated that 3-5% of people infected with typhoid fever become chronic carriers. Studies have demonstrated that a mechanism of chronic carriage involves biofilm formation on gallstone surfaces. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.00774-18DOI Listing
April 2019
1 Read

Clinical characteristics and etiologies of bronchiectasis in Korean children: A multicenter retrospective study.

Respir Med 2019 Apr 6;150:8-14. Epub 2019 Feb 6.

Department of Pediatrics, Eulji General Hospital, Eulji University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Bronchiectasis is a chronic pulmonary disease characterized by progressive and irreversible bronchial dilatation. The aim of the present study was to investigate the etiologies and clinical features of bronchiectasis in Korean children.

Methods: We performed a retrospective review of the medical records for children diagnosed with bronchiectasis between 2000 and 2017 at 28 secondary or tertiary hospitals in South Korea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmed.2019.01.018DOI Listing
April 2019
3 Reads

Cold-induced urticaria in a child with familial Mediterranean fever.

J Allergy Clin Immunol Pract 2019 Apr;7(4):1376

Division of Allergy and Clinical Immunology, Department of Pediatrics, University of Health Sciences, Ankara Health Research and Application Center, Ankara, Turkey.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22132198193007
Publisher Site
http://dx.doi.org/10.1016/j.jaip.2019.01.019DOI Listing
April 2019
4 Reads

From uncertainty to gradually managing and awaiting recovery of a periodic condition- a qualitative study of parents´ experiences of PFAPA syndrome.

BMC Pediatr 2019 Apr 8;19(1):99. Epub 2019 Apr 8.

Department of Pediatrics, NU-Hospital Group, Uddevalla, Sweden.

Background: The prevalence of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is unknown. Although an uncommon condition, it is considered to be the most common autoinflammatory disease among children in many parts of the world. The knowledge of the consequences of the recurrent fever episodes for the child and its family are limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1458-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454720PMC

Secondary Adrenal Insufficiency due to Intra-articular Glucocorticoid Injections.

Indian Pediatr 2019 Mar;56(3):242-243

Department of Pediatric and Adolescent Endocrinology, Institute of Pediatrics, Jagiellonian University Medical College, and Children's University Hospital, Krakow, Poland.

Background: The most common cause of hypothalamic-pituitary-adrenal axis suppression is systemic glucocorticoids administration.

Case Characteristics: A 14-year-old boy with juvenile idiopathic arthritis receiving repeated intra-articular steroids for last 3 years developed fever, fatigue, nausea and abdominal pain. Stimulation with low-dose Synathen revealed low adrenal reserve, suggesting secondary adrenal insufficiency. Read More

View Article

Download full-text PDF

Source
March 2019
2 Reads

Characteristics of regulatory T-cell populations before and after Ty21a typhoid vaccination in children and adults.

Clin Immunol 2019 Apr 4;203:14-22. Epub 2019 Apr 4.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA; Molecular Microbiology and Immunology Department, University of Maryland Graduate Program in Life Sciences, Baltimore, MD, USA; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Typhoid fever, caused by the pathogen Salmonella enterica serovar Typhi (S. Typhi), is a serious global health concern. Challenge studies with wild type S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.04.002DOI Listing
April 2019
3 Reads

A Healthy Toddler With Fever and Lethargy.

Pediatrics 2019 Apr 5. Epub 2019 Apr 5.

Division of Hospital Medicine and

A 21-month-old previously healthy girl presented to the emergency department initially with fever, rhinorrhea, and poor oral intake. She was subsequently discharged from the hospital on amoxicillin for treatment of acute otitis media but presented hours later on the same day with continued poor oral intake, decreased urine output, and lethargy. The patient was afebrile on examination without a focal source of infection or evidence of meningismus, but she was lethargic and minimally responsive to pain and had reduced strength in the upper and lower extremities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2018-0412DOI Listing
April 2019
1 Read

Diversity of Salmonella Typhi-responsive CD4 and CD8 T cells before and after Ty21a typhoid vaccination in children and adults.

Int Immunol 2019 Apr 5. Epub 2019 Apr 5.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Typhoid fever is a life-threatening disease caused by the human-restricted pathogen Salmonella enterica serovar Typhi (S. Typhi). The oral live attenuated Ty21a typhoid vaccine protects against this severe disease by eliciting robust, multifunctional cell-mediated immunity (CMI), shown to be associated with protection in wild-type S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/intimm/dxz011DOI Listing
April 2019
2 Reads

Roseamonas gilardii Bacteremia in a Patient With HbSβ0-thalassemia: Clinical Implications and Literature Review.

J Pediatr Hematol Oncol 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatrics, Division of Pediatric Hematology and Oncology.

Roseamonas gilardii is a gram-negative coccobacillus identified in immunocompromised pediatric patients. A 5-year-old male with a history of HbSβ thalassemia status postsurgical splenectomy presented to the emergency department with fever. Blood cultures grew R. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPH.0000000000001476DOI Listing
April 2019
1 Read

Tofacitinib Treatment of Refractory Systemic Juvenile Idiopathic Arthritis.

Pediatrics 2019 Apr 4. Epub 2019 Apr 4.

Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China; and

Systemic juvenile idiopathic arthritis (sJIA) is an aggressive form of childhood arthritis accompanied by persistent systemic inflammation. Patients with sJIA often exhibit poor response to conventional disease-modifying antirheumatic drugs, and chronic glucocorticoid use is associated with significant adverse effects. Although biologics used to target interleukin 1 and interleukin 6 are efficacious, the long-term commitment to frequent injections or infusions remains a challenge in young children. Read More

View Article

Download full-text PDF

Source
http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
Publisher Site
http://dx.doi.org/10.1542/peds.2018-2845DOI Listing
April 2019
4 Reads

Onychomadesis in a 20-Month-Old Child with Kawasaki Disease.

Case Rep Pediatr 2019 3;2019:3156736. Epub 2019 Mar 3.

Clinical Associate Professor of Pediatrics and Associate Member at the Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, Canada.

Kawasaki disease is characterized by fever for ≥ five days, bilateral bulbar conjunctival injection without exudate, polymorphous rash changes in the extremities, oral mucosal changes, and cervical lymphadenopathy. We report a 20-month-old boy with Kawasaki disease who had onychomadesis affecting the fingernails and toenails bilaterally. To our knowledge, there were three reported cases of onychomadesis associated with Kawasaki disease, to which we add another one. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/3156736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421722PMC
March 2019
1 Read

Protocol for a systematic review of time to antibiotics (TTA) in patients with fever and neutropenia during chemotherapy for cancer (FN) and interventions aiming to reduce TTA.

Syst Rev 2019 Apr 3;8(1):82. Epub 2019 Apr 3.

Centre for Reviews and Dissemination, University of York, York, UK.

Background: Fever and neutropenia (FN) is a common complication of chemotherapy for cancer. Prompt empiric broad-spectrum antibiotic therapy in FN is typically considered standard of care, but the definition of prompt is not clear. We seek to systematically review the available data on the association between time to antibiotics (TTA) administration and clinical outcomes in patients with FN being treated with chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13643-019-1006-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446276PMC
April 2019
2 Reads

Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children.

BMC Pulm Med 2019 Apr 2;19(1):71. Epub 2019 Apr 2.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.

Background: Differentiating bacterial from viral pneumonia is important for guiding targeted management and judicious use of antibiotics. We assessed if clinical characteristics and blood inflammatory biomarkers could be used to distinguish bacterial from viral pneumonia.

Methods: Western Australian children (≤17 years) hospitalized with radiologically-confirmed community-acquired pneumonia were recruited and clinical symptoms and management data were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0835-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444754PMC
April 2019
1 Read

Acute rheumatic fever associated with tenosynovitis and a unique cytokine profile.

Immunol Med 2018 Mar 3;41(1):43-45. Epub 2018 Apr 3.

a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.

Acute rheumatic fever (ARF), caused by group A β-hemolytic streptococcus infection, is characterized by inflammation affecting several organs. There are few reports on magnetic resonance imaging (MRI) findings in patients with ARF. An 8-year-old Japanese boy presented with a prolonged fever of unknown cause and swelling of his right hand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09114300.2018.1451617DOI Listing
March 2018
10 Reads

State of care for patients with systemic autoinflammatory diseases - Results of a tertiary care survey.

World Allergy Organ J 2019 14;12(3):100019. Epub 2019 Mar 14.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: Systemic autoinflammatory diseases (SAIDs) are rare debilitating disorders of which there is limited awareness and a significant delay in diagnosis. There is no uniform approach in the diagnosis and treatment of these disorders and the real life state of SAID patient care is poorly characterized. The aim of this study was to obtain data on the epidemiology, state of care and the perception of physicians who are involved in the care of SAID patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.waojou.2019.100019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439415PMC
March 2019
6 Reads

Association of Hypocapnia in Children with Febrile Seizures.

J Pediatr Neurosci 2018 Oct-Dec;13(4):388-391

Department of Paediatrics, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India.

Introduction: Febrile seizure is a benign condition in children. Susceptibility genes associated with febrile convulsions have been identified, but the precise pathophysiologic mechanism that triggers febrile seizure is unclear. Using animal models, it has been demonstrated that hyperthermia causes respiratory alkalosis with consequent brain alkalosis and seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JPN.JPN_73_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413613PMC
April 2019
3 Reads

Case 3: Two Preschoolers with Fever.

Pediatr Rev 2019 Apr;40(4):197-201

Children's Hospital of Philadelphia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/pir.2016-0202DOI Listing

Human bile-mediated regulation of curli fimbriae.

J Bacteriol 2019 Apr 1. Epub 2019 Apr 1.

Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA

Typhoid fever is caused primarily by serovar Typhi ( Typhi). Approximately 3-5% of individuals infected with Typhi become chronic carriers with the gallbladder (GB) as the site of persistence, as gallstones within the GB are a platform on which the bacteria form a biofilm. Typhi is a human-restricted pathogen; therefore, asymptomatic carriers represent a critical reservoir for further spread of disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.00055-19DOI Listing
April 2019
1 Read

Modification of the vaccine manufacturing process improves the pyrogenicity profile of inactivated influenza vaccines in young children.

Vaccine 2019 Apr 29;37(18):2447-2454. Epub 2019 Mar 29.

Clinical Development, Seqirus Pty Ltd, Parkville, Victoria, Australia. Electronic address:

Background: There were increased reports of fevers and febrile reactions in young children (particularly children aged <5 years) receiving the Seqirus/CSL Southern Hemisphere 2010 trivalent inactivated influenza vaccine (IIV3). Modifying the vaccine manufacturing process by increasing the minimum concentration of splitting agent (sodium taurodeoxycholate [TDOC]) from 0.5% w/v to 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2019.03.056DOI Listing

Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study.

BMC Pediatr 2019 Apr 1;19(1):87. Epub 2019 Apr 1.

Department of Pediatrics, Faculty of Medicine, Colombo, Sri Lanka.

Background: Series of biochemical and haematological changes occur during the course of dengue infection, which vary depending on the clinical disease. The patterns of change are not well documented and identifying these patterns in children with dengue infection would help to anticipate the progression to different clinical stages thus enabling effective management.

Methods: A prospective follow up study was conducted during the period of July 2013 - April 2014 at Professorial Pediatric unit, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1451-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442420PMC
April 2019
1 Read

Effects of Smoking on the Prevalence of Allergic Disorders in Russian Adolescents: A Retrospective Cross-sectional Study.

Cureus 2019 Jan 18;11(1):e3912. Epub 2019 Jan 18.

Pediatrics, Central Clinical Hospital of Russian Academy of Sciences, Moscow, RUS.

Introduction Smoking is one of the leading causes of death. Smoking also decreases lung efficiency and impairs lung function in children of all ages. Second-hand tobacco smoking increases both the frequency and severity of childhood asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426574PMC
January 2019
1 Read

Expert panel diagnosis demonstrated high reproducibility as reference standard in infectious diseases.

J Clin Epidemiol 2019 Mar 28. Epub 2019 Mar 28.

Division of Pediatric Immunology and Infectious Diseases, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

Objective: If a gold standard is lacking in a diagnostic test accuracy study, expert diagnosis is frequently used as reference standard. However, inter- and intra-observer agreements are imperfect. The aim of this study was to quantify the reproducibility of a panel diagnosis for pediatric infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinepi.2019.03.010DOI Listing
March 2019
3 Reads

Predicting the outcomes of targeted temperature management for children with seizures and/or impaired consciousness accompanied by fever without known etiology.

Brain Dev 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Seizures and/or impaired consciousness accompanied by fever without known etiology (SICF) is common in the pediatric emergency setting. No optimal strategy for the management of SICF in childhood currently exists. We previously demonstrated the effectiveness of targeted temperature management (TTM) against SICF with a high risk of morbidity; however, some patients with SICF develop neurological sequelae despite TTM, which necessitate additional neuroprotective treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2019.03.007DOI Listing
March 2019
2 Reads

The Changing Concepts Regarding the Mediterranean Fever Gene: Toward a Spectrum of Pyrin-Associated Autoinflammatory Diseases with Variable Heredity.

J Pediatr 2019 Mar 27. Epub 2019 Mar 27.

AP-HP, CHU de Bicetre, Pediatric Rheumatology, CEREMAIA, Le Kremlin Bicetre, Bicetre, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2019.02.039DOI Listing
March 2019
2 Reads

Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.

Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205

15 Department of Research and Quality, American Academy of Otolaryngology-Head and Neck Surgery Foundation, Alexandria, Virginia, USA.

Objective: This update of a 2011 guideline developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation provides evidence-based recommendations on the pre-, intra-, and postoperative care and management of children 1 to 18 years of age under consideration for tonsillectomy. Tonsillectomy is defined as a surgical procedure performed with or without adenoidectomy that completely removes the tonsil, including its capsule, by dissecting the peritonsillar space between the tonsil capsule and the muscular wall. Tonsillectomy is one of the most common surgical procedures in the United States, with 289,000 ambulatory procedures performed annually in children <15 years of age, based on the most recent published data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0194599818807917DOI Listing
February 2019
1 Read

A medical records and data capture and management system for Lassa fever in Sierra Leone: Approach, implementation, and challenges.

PLoS One 2019 28;14(3):e0214284. Epub 2019 Mar 28.

Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, United States of America.

Situated in southeastern Sierra Leone, Kenema Government Hospital (KGH) maintains one of the world's only Lassa fever isolation wards and was a strategic Ebola virus disease (EVD) treatment facility during the 2014 EVD outbreak. Since 2006, the Viral Hemorrhagic Fever Consortium (VHFC) has carried out research activities at KGH, capturing clinical and laboratory data for suspected cases of Lassa fever. Here we describe the approach, progress, and challenges in designing and maintaining a data capture and management system (DCMS) at KGH to assist infectious disease researchers in building and sustaining DCMS in low-resource environments. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214284PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438490PMC
March 2019
2 Reads

Diagnostic accuracy of pediatric atypical appendicitis: Three case reports.

Medicine (Baltimore) 2019 Mar;98(13):e15006

Department of Pediatrics, Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital.

Rationale: Acute appendicitis is one of the most common causes of acute abdomen in children, yet it is difficult to diagnose in young children because its clinical manifestations may be atypical. Here, 3 atypical clinical cases associated with appendicitis in children are reported.

Patient Concern: The 1st case corresponds to a 5-year-old male patient who presented with abdominal discomfort, intermittent fevers, and vomiting, have increased white blood cell (WBC) count and C-reactive protein (CRP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015006DOI Listing
March 2019
3 Reads