1,505 results match your criteria Pediatrics Febrile Seizures


Neuroimaging for Pediatric Non-First-Time Seizures in the Emergency Department.

Neurol Clin Pract 2022 Jun;12(3):e7-e13

Section of Neurology (EM, SR, ES, JJ, JM, RM, MS), Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora; Section of Emergency Medicine Department of Pediatrics (RDM, JL), University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora; and Division of Neurology (CAP), Department of Pediatrics, Children's Hospital of Philadelphia, PA.

Background And Objectives: Neuroimaging is often part of the workup for a pediatric patient presenting with a seizure to an emergency department (ED). We aim to evaluate when neuroimaging in the ED for children with a non-first-time seizure, or nonindex seizure (NIS), is associated with an acute change in management (ACM).

Methods: This is a retrospective cohort study of all pediatric patients presenting to an ED from 2008 to 2018 with a NIS, excluding repeat febrile seizures, who underwent neuroimaging. Read More

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Snotwatch: an ecological analysis of the relationship between febrile seizures and respiratory virus activity.

BMC Pediatr 2022 Jun 22;22(1):359. Epub 2022 Jun 22.

Department of Paediatrics, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.

Background: Febrile seizures are the commonest type of seizure in occurring in the first few years of life, mostly affecting children aged six months to five years old. While largely benign, the incidence of each febrile seizure increases the risk of recurrence, afebrile seizures and epilepsy. Viruses are the most frequent cause of febrile illnesses in which a febrile seizure occurs. Read More

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Risk factors for acute encephalitis and early seizure recurrence in complex febrile seizures.

Eur J Pediatr 2022 Jun 17. Epub 2022 Jun 17.

Department of Pediatrics, National Hospital Organization Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu, Oita, 874-0011, Japan.

The purpose of this study is to elucidate risk factors for central nervous system infection and early seizure recurrence in children with febrile seizures (FSs) and thus facilitate outpatient management of complex FS. This single-center, retrospective cohort study investigated 688 children (6-60 months old) with FSs in Japan during 2011-2021. We investigated the incidence and clinical manifestations of children with acute encephalitis or bacterial meningitis. Read More

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Association of rs16944 Polymorphism With Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion Is Opposite to That of Febrile Seizures.

Front Neurol 2022 30;13:891721. Epub 2022 May 30.

Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Objective: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a severe neurologic complication of febrile infectious diseases in children. At the onset, AESD is clinically manifested as febrile status epilepticus. Subsequent damage to the cerebral cortex is ascribed to neurotoxicity. Read More

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Efficacy of Oral vs. Intravenous Calcium Supplementation for Continuation Therapy in Hypocalcemic Seizures: A Randomized, Controlled Trial.

Indian J Pediatr 2022 Jun 15. Epub 2022 Jun 15.

Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India.

Objective: To evaluate efficacy of oral vs. intravenous calcium supplementation for continuation therapy in hypocalcemic seizures.

Methods: Sixty children between 1 mo and 5 y presenting with hypocalcemic seizures without any other underlying febrile, chronic systemic disease, or acute neurological illness were included. Read More

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Anti-inflammatory and immune-mediated therapy for a case of febrile infection-related epilepsy syndrome with rapid recurrence.

Clin Case Rep 2022 Jun 7;10(6):e5952. Epub 2022 Jun 7.

Pediatrics Department Okinawa Prefectural Nanbu Medical Center and Children's Medical Center Shimajiri-gun Okinawa Japan.

Febrile infection-related epilepsy syndrome (FIRES) is a disease of unknown etiology, characterized by refractory frequent focal seizures, which require prolonged intensive care. We successfully treated a boy with FIRES with anti-inflammatory and immunosuppressive therapy. This case suggests that an autoimmune mechanism may play a role in the development of FIRES. Read More

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Simple and complex febrile seizures: is there such a difference? Management and complications in an emergency department.

Neurologia (Engl Ed) 2022 Jun 27;37(5):317-324. Epub 2021 May 27.

Hospital Universitario Gregorio Marañón, Madrid, Spain.

Objective: We aimed to analyse the prevalence, characteristics, and management of simple and complex febrile seizures. The secondary objective was to compare the risk of underlying organic lesion and epilepsy in both types of seizures, with a particular focus on the different subtypes defining a complex febrile seizure.

Material And Methods: We performed a retrospective cohort study including patients aged 0--16 years who were treated for febrile seizures in the paediatric emergency department of a tertiary hospital over a period of 5 years. Read More

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-Related Epilepsy: Novel Mutations and Rare Phenotypes.

Front Mol Neurosci 2022 19;15:826183. Epub 2022 May 19.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: To expand the genotypes and phenotypes of sodium voltage-gated channel alpha subunit 1 (SCN1A)-related epilepsy.

Methods: We retrospectively collected the clinical and genetic information of 22 epilepsy patients (10 males, 12 females; mean: 9.2 ± 3. Read More

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Febrile Seizures among Children Admitted to the Department of Paediatrics of a Tertiary Care Centre: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2022 Apr 15;60(248):348-351. Epub 2022 Apr 15.

Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.

Introduction: Febrile seizure is the most common convulsive event in children younger than 60 months. Fever plays an important role in causing disturbances in fluid and electrolyte balance, also hyponatremia has been thought to enhance the susceptibility to seizures. The objective of this study is to find out the prevalence of febrile seizures among children admitted to the Department of Paediatrics of a tertiary care centre. Read More

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Variants as the Underlying Cause of Genetic Epilepsy with Febrile Seizures Plus in Two Multi-Generational Colombian Families.

Genes (Basel) 2022 Apr 25;13(5). Epub 2022 Apr 25.

Center for Statistical Genetics, Gertrude H. Sergievsky Center, and the Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.

Genetic epilepsy with febrile seizures plus (GEFS+) is an autosomal dominant disorder with febrile or afebrile seizures that exhibits phenotypic variability. Only a few variants in have been previously characterized for GEFS+, in Latin American populations where studies on the genetic and phenotypic spectrum of GEFS+ are scarce. We evaluated members in two multi-generational Colombian Paisa families whose affected members present with classic GEFS+. Read More

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Recessive Mutations Are Associated With Febrile Seizures and Epilepsy With Antecedent Febrile Seizures and the Genotype-Phenotype Correlation.

Front Mol Neurosci 2022 10;15:861159. Epub 2022 May 10.

Department of Neurology, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Objective: The encodes polycystin-1, a large transmembrane protein that plays important roles in cell proliferation, apoptosis, and cation transport. Previous studies have identified mutations in autosomal dominant polycystic kidney disease (ADPKD). However, the expression of in the brain is much higher than that in the kidney. Read More

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Hyponatremia and Recurrent Febrile Seizures During Febrile Episodes: A Meta-Analysis.

Cureus 2022 Apr 22;14(4):e24398. Epub 2022 Apr 22.

Department of Pediatrics, Haibara General Hospital, Shizuoka, JPN.

Several studies have investigated the potential effects of hyponatremia on recurrent febrile seizures (RFS) during febrile illness. Because findings were inconsistent across studies, we aimed to evaluate the serum sodium levels in febrile seizures (FS) of children with or without RFS during the same episode. We conducted electronic searches in three databases (PubMed, EMBASE, Cochrane Library) and one scholarly search engine (Google Scholar) up to June 2021 for studies on FS. Read More

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Is Associated With Febrile Seizures and Epilepsy With Febrile Seizures Plus.

Front Mol Neurosci 2022 6;15:889534. Epub 2022 May 6.

Department of Neurology, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Purpose: To identify novel genetic causes of febrile seizures (FS) and epilepsy with febrile seizures plus (EFS+).

Methods: We performed whole-exome sequencing in a cohort of 32 families, in which at least two individuals were affected by FS or EFS+. The probands, their parents, and available family members were recruited to ascertain whether the genetic variants were co-segregation. Read More

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The Negative Association between Breastfeeding Duration and Infant Febrile Seizure: A Retrospective Case-Control Study.

Int J Environ Res Public Health 2022 05 1;19(9). Epub 2022 May 1.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan.

Two to five percent of infants and children experience febrile seizures (FS). Breastfeeding is beneficial to the health of mothers and children. Nevertheless, the benefits of breastfeeding in reducing FS remain unclear; thus, the present study aimed to evaluate this association. Read More

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Establishment of achievable benchmarks of care in the neurodiagnostic evaluation of simple febrile seizures.

J Hosp Med 2022 May 13;17(5):327-341. Epub 2022 May 13.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.

Background: Current guidelines recommend against neurodiagnostic testing for the evaluation of simple febrile seizures.

Objectives: (1) Assess overall and institutional rates of neurodiagnostic testing and (2) establish achievable benchmarks of care (ABCs) for children evaluated for simple febrile seizures at children's hospitals.

Design, Setting, And Participants: Cross-sectional study of children 6 months to 5 years evaluated in the emergency department (ED) 2016-2019 with simple febrile seizures at 38 children's hospitals in Pediatric Health Information System database. Read More

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Provoked seizures and status epilepticus in a pediatric population with COVID-19 disease.

Epilepsia 2022 May 9. Epub 2022 May 9.

Departments of Neurology and Pediatrics, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.

We are reporting 16 pediatric patients (ages 0-18-years-old) who presented to our urban hospital emergency room with seizures and coronavirus disease 2019 (COVID-19) during the surge of the Omicron variant. There was an increased number of pediatric patients with seizures and COVID-19 during this period as compared to prior COVID-19 surges. The 16 patients ranged in age from 3 months to 12 years of age. Read More

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Fever-Associated Seizures or Epilepsy: An Overview of Old and Recent Literature Acquisitions.

Front Pediatr 2022 21;10:858945. Epub 2022 Apr 21.

Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, AOU "Policlinico", PO "G. Rodolico", Catania, Italy.

In addition to central nervous system infections, seizures and fever may occur together in several neurological disorders. Formerly, based on the clinical features and prognostic evolution, the co-association of seizure and fever included classical febrile seizures (FS) divided into simple, complex, and prolonged FS (also called febrile status epilepticus). Later, this group of disorders has been progressively indicated, with a more inclusive term, as "fever-associated seizures or epilepsy" (FASE) that encompasses: (a) FS divided into simple, complex, and prolonged FS; (b) FS plus; (c) severe myoclonic epilepsy in infancy (Dravet syndrome); (d) genetic epilepsy with FS plus; and (e) febrile infection-related epilepsy syndrome (FIRES). Read More

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Liraglutide Is Protective against Brain Injury in Mice with Febrile Seizures by Inhibiting Inflammatory Factors.

Comput Math Methods Med 2022 29;2022:7563281. Epub 2022 Apr 29.

Department of Pediatrics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China.

The febrile seizure (FS) is a common disease in emergency pediatrics, and about 30% of patients are children aged between 6 months and 5 years. Therefore, we aim to observe the protective impact of liraglutide (LIR) on brain injury in mice with FS and to explore its relevant mechanisms. Male SD mice were selected, and the FS model was established by heat bath method. Read More

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Background incidence rates of adverse events of special interest related to COVID-19 vaccines in Ontario, Canada, 2015 to 2020, to inform COVID-19 vaccine safety surveillance.

Vaccine 2022 May 27;40(24):3305-3312. Epub 2022 Apr 27.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; ICES, Toronto, ON, Canada; Public Health Ontario, ON, Canada; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada. Electronic address:

Background: Background incidence rates are critical in pharmacovigilance to facilitate identification of vaccine safety signals. We estimated background incidence rates of 11 adverse events of special interest related to COVID-19 vaccines in Ontario, Canada.

Methods: We conducted a population-based retrospective observational study using linked health administrative databases for hospitalizations and emergency department visits among Ontario residents. Read More

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Profiles of indigenous patients with epilepsy in a Brazilian village.

Epilepsy Behav 2022 06 5;131(Pt A):108703. Epub 2022 May 5.

Department of Neuroscience and Behavioral Science, Division of Neurology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

Introduction: Identifying epilepsy in local indigenous populations and describing its epidemiological, etiological, electroencephalographic, and therapeutic aspects can assist public health policies planning toward epilepsy in indigenous communities.

Methods: This descriptive, cross-sectional study investigated epilepsy among indigenous people residing in Jaguapirú Village, Dourados, Mato Grosso do Sul, Brazil. Participants had their clinical histories reviewed and physical examination performed, as well as one or more electroencephalograms (EEG) registered. Read More

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International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions.

Epilepsia 2022 06 3;63(6):1398-1442. Epub 2022 May 3.

Robert Debré Hospital, Public Hospital Network of Paris, NeuroDiderot, National Institute of Health and Medical Research, Department Medico-Universitaire Innovation Robert-Debré, Pediatric Neurology, University of Paris, Paris, France.

The 2017 International League Against Epilepsy classification has defined a three-tier system with epilepsy syndrome identification at the third level. Although a syndrome cannot be determined in all children with epilepsy, identification of a specific syndrome provides guidance on management and prognosis. In this paper, we describe the childhood onset epilepsy syndromes, most of which have both mandatory seizure type(s) and interictal electroencephalographic (EEG) features. Read More

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Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures.

Epilepsia 2022 Apr 29. Epub 2022 Apr 29.

Department of General Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Objective: This study was undertaken to evaluate the efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen in comparison with as-needed acetaminophen alone for prevention of seizure recurrence during the same fever episode in suspected pediatric simple febrile seizures (SFS).

Methods: This single-center, prospective, observational study was conducted from July 29, 2019 to February 15, 2021 at a children's hospital. Children aged 6 months to 60 months presenting to the emergency department with suspected SFS were included. Read More

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Multifocal multilobar focal cortical dysplasia type IIa in Febrile Infection Related Epilepsy Syndrome (FIRES).

Clin Neurol Neurosurg 2022 06 11;217:107247. Epub 2022 Apr 11.

Department of Neurology, Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, RI, United States; Division of Child Neurology, Department of Pediatrics, Hasbro Children's Hospital, Providence, RI, United States.

A seven-year-old girl with history of type I diabetes and no history of seizures presented for altered mental status with convulsions nearly one week after a febrile illness. Serum and laboratory studies were normal with EEG showing biparietal fast activity and seizures originating from right occipital lobe consistent with FIRES. A collaborative decision was ultimately made to withdraw care. Read More

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-Related Epilepsy: The Phenotypic Spectrum, Treatment and Prognosis.

Front Mol Neurosci 2022 30;15:809951. Epub 2022 Mar 30.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Objective: The aim of this study was to analyze the phenotypic spectrum, treatment, and prognosis of 72 Chinese children with variants.

Methods: The variants were detected by next-generation sequencing. All patients were followed up at a pediatric neurology clinic in our hospital or by telephone. Read More

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Surgery for intractable epilepsy after severe encephalopathy with reversible splenial lesion and new onset hippocampal lesion associated with parechovirus.

Brain Dev 2022 Jun 4;44(6):410-414. Epub 2022 Apr 4.

Department of Neurosurgery, Epilepsy Center, Juntendo University, Tokyo, Japan. Electronic address:

We describe a case of severe encephalopathy with reversible splenial lesion associated with parechovirus, followed by intractable temporal lobe epilepsy (TLE), which was improved by epilepsy surgery. A 3-year-old girl was admitted because of fever, consciousness disturbance and generalized tonic clonic seizure. Her seizure lasted for four hours. Read More

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Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies.

Nat Commun 2022 04 5;13(1):1822. Epub 2022 Apr 5.

Brain and Mind Centre, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Many patients with developmental and epileptic encephalopathies present with variants in genes coding for GABA receptors. These variants are presumed to cause loss-of-function receptors leading to reduced neuronal GABAergic activity. Yet, patients with GABA receptor variants have diverse clinical phenotypes and many are refractory to treatment despite the availability of drugs that enhance GABAergic activity. Read More

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Phenotypic Spectrum and Prognosis of Epilepsy Patients With Variants.

Front Mol Neurosci 2022 14;15:809163. Epub 2022 Mar 14.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Objective: This study aimed to obtain a comprehensive understanding of the genetic and phenotypic aspects of -related epilepsy and its prognosis and to explore the potential prospects for personalized medicine.

Methods: Through a multicenter collaboration in China, we analyzed the genotype-phenotype correlation and antiseizure medication (ASM) of patients with -related epilepsy. The three-dimensional protein structure of the variant was modeled to predict the effect of missense variants using PyMOL 2. Read More

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Pediatric Encephalopathy and Complex Febrile Seizures.

Clin Pediatr (Phila) 2022 Jul 30;61(7):493-498. Epub 2022 Mar 30.

Division of Neurology, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and Stollery Children's Hospital, Edmonton, AB, Canada.

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Effect of the COVID-19 Lockdown on Asthma Biological Rhythms.

J Biol Rhythms 2022 Apr 23;37(2):152-163. Epub 2022 Mar 23.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

Asthma has a striking temporal character, in which time-of-day, patient age, and season each influence disease activity. The extent to which rhythms in asthma activity reflect exposure to specific disease triggers remains unclear. In this study, we examined how virus mitigation strategies enacted during the COVID-19 pandemic ("lockdown measures") affected rhythms in asthma clinical activity in children. Read More

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The baseline risk of multiple febrile seizures in the same febrile illness: a meta-analysis.

Eur J Pediatr 2022 Jun 16;181(6):2201-2213. Epub 2022 Mar 16.

Department of Neurology, Children's Hospital of Richmond, VCU Health System, Richmond, VA, USA.

The baseline risk for multiple febrile seizures within the same febrile illness is largely unknown. Estimates range from 5 to 30%. Imprecise estimates can lead to incorrectly powering studies investigating the management of febrile seizures. Read More

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