1,183 results match your criteria Pediatrics Febrile Seizures


Febrile seizures with leukocytosis as a predictor for occult bacteremia.

Pediatr Int 2019 Apr 12. Epub 2019 Apr 12.

Division of Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, JPN.

Background: Febrile children 3-36 months old, who had a body temperature > 39 °C and white blood cell count > 15,000/mm were known to be at risk for occult pneumococcal bacteremia (OPB) in the pre-pneumococcal conjugate vaccine (PCV) era. However, the positive predictive value of this criteria decreased dramatically after introduction of PCV, which indicates a need for alternative criteria. Previous studies demonstrated a high rate of febrile seizures in children with OPB, suggesting that screening may still be practical in this population. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.13862
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http://dx.doi.org/10.1111/ped.13862DOI Listing
April 2019
1 Read

Top studies relevant to primary care from 2018: From PEER.

Can Fam Physician 2019 Apr;65(4):260-263

Director of Programs and Practice Support for the College of Family Physicians of Canada and Professor in the Department of Family Medicine at the University of Alberta.

Objective: To summarize high-quality studies for 10 topics from 2018 that have strong relevance to primary care practice.

Quality Of Evidence: Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching . Read More

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April 2019
1 Read

SCN1A mutations in focal epilepsy with auditory features: widening the spectrum of GEFS plus.

Epileptic Disord 2019 Apr 12. Epub 2019 Apr 12.

Medical Genetics Unit, Sant'Orsola-Malpighi University Hospital, Bologna.

Epilepsy with auditory features (EAF) is a focal epilepsy syndrome characterized by prominent auditory ictal manifestations. Two main genes, LGI1 and RELN, have been implicated in EAF, but the genetic aetiology remains unknown in half of families and most sporadic cases. We previously described a pathogenic SCN1A missense variant (p. Read More

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http://dx.doi.org/10.1684/epd.2019.1046DOI Listing
April 2019
11 Reads

Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization.

Pediatr Emerg Care 2019 Apr 3. Epub 2019 Apr 3.

Objective: A brief resolved unexplained event (BRUE) in infancy is a common reason for visiting the emergency department. However, little is known about the long-term outcomes of such an event. This study evaluates future mortality, morbidity, and/or developmental outcome after a BRUE. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001816DOI Listing
April 2019
4 Reads

Association of Hypocapnia in Children with Febrile Seizures.

J Pediatr Neurosci 2018 Oct-Dec;13(4):388-391

Department of Paediatrics, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India.

Introduction: Febrile seizure is a benign condition in children. Susceptibility genes associated with febrile convulsions have been identified, but the precise pathophysiologic mechanism that triggers febrile seizure is unclear. Using animal models, it has been demonstrated that hyperthermia causes respiratory alkalosis with consequent brain alkalosis and seizures. Read More

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http://dx.doi.org/10.4103/JPN.JPN_73_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413613PMC
April 2019
2 Reads

MEF2C-related epilepsy: Delineating the phenotypic spectrum from a novel mutation and literature review.

Seizure 2019 Mar 22. Epub 2019 Mar 22.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Purpose: MEF2C-related epilepsy has been poorly described in the literature, despite a consistent MEF2C haploinsufficiency phenotype characterized by severe language impairment and motor delay (MIM# 613443). We aimed to delineate the spectrum of electroclinical manifestations of MEF2C-related epilepsy from an illustrative case and literature review.

Methods: A retrospective chart review of our case was performed followed by a literature review on PubMed and OMIM. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.015DOI Listing
March 2019
2 Reads

Paramedic-Identified Enablers of and Barriers to Pediatric Seizure Management: A Multicenter, Qualitative Study.

Prehosp Emerg Care 2019 Mar 27:1-14. Epub 2019 Mar 27.

a Baylor College of Medicine, Department of Pediatrics, Section of Emergency Medicine , Texas Children's Hospital , 6621 Fannin Street , Houston , 77030 United States.

Background: Seizures have the potential to cause significant morbidity and mortality, and are a common reason EMS are requested for a child. An evidence-based guideline (EBG) for pediatric prehospital seizures was published and has been implemented as protocol in multiple EMS systems. Knowledge translation and protocol adherence in medicine can be incomplete. Read More

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http://dx.doi.org/10.1080/10903127.2019.1595234DOI Listing
March 2019
1 Read

A case of Dravet Syndrome with a newly defined mutation in the SCN1A gene.

Turk Pediatri Ars 2018 Dec 1;53(4):259-262. Epub 2018 Dec 1.

Department of Pediatrics, Division of Pediatric Neurology, Ankara University School of Medicine, Ankara, Turkey.

Dravet syndrome is a catastrophic progressive epileptic syndrome. De novo loss of function mutations on the SCN1A gene coding voltage-gated sodium channels are responsible. Disruption of the triggering of hippocampal GABAergic interneurons is assumed as the cause of fall in the seizure threshold. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.4197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408181PMC
December 2018
3 Reads

Severe Factor X Deficiency Presenting as Febrile Seizure in an Infant.

J Pediatr Hematol Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Corneal Surgery and Ophthalmology, SK Soni Hospital, Jaipur, Rajasthan, India.

Factor X deficiency is a severe inherited coagulation disorder, which is characterized by severe systemic bleeding manifestations in affected individuals. It is a rare disorder with a frequency of around 1:1,000,000 in the general population. We present the case of an infant with factor X deficiency who presented with complex febrile seizure. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001453DOI Listing
March 2019
2 Reads

Early administration of vitamins B1 and B6 and l-carnitine prevents a second attack of acute encephalopathy with biphasic seizures and late reduced diffusion: A case control study.

Brain Dev 2019 Mar 9. Epub 2019 Mar 9.

Division of Neurology, National Center for Child Health and Development, Japan.

Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most prevalent encephalopathy in Japanese children. AESD is characterized by a prolonged febrile seizure on day 1 followed by secondary seizures and MRI abnormality on days 4-6, resulting in high incidence of neurological sequelae. We aimed to clarify whether early administration of vitamins (vitamin B1, vitamin B6, and l-carnitine) would improve the clinical course of AESD. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.02.015DOI Listing

G327E mutation in SCN9A gene causes idiopathic focal epilepsy with Rolandic spikes: a case report of twin sisters.

Neurol Sci 2019 Mar 4. Epub 2019 Mar 4.

Department of pediatrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Foshan, 528000, Guangdong, China.

The voltage-gated sodium channel NaV1.7, encoded by the gene SCN9A, is located in peripheral neurons and plays an important role in epileptogenesis. Previous studies have identified an increasing number of SCN9A mutations in patients with variable epilepsy phenotypes. Read More

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http://dx.doi.org/10.1007/s10072-019-03752-3DOI Listing
March 2019
7 Reads

Clinico-epidemiological Study of Viral Acute Encephalitis Syndrome Cases and Comparison to Nonviral Cases in Children from Eastern India.

J Glob Infect Dis 2019 Jan-Mar;11(1):7-12

Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Objectives: The objective is to study the clinico-epidemiological features of viral acute encephalitis syndrome (AES) cases and compare them with nonviral AES cases in children from Eastern India.

Methods: This prospective observational study was conducted in the department of pediatrics of a tertiary care teaching hospital in Eastern India over 18-month period. Children (6 months to 15 years) with acute onset of fever (≥37. Read More

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http://dx.doi.org/10.4103/jgid.jgid_26_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380098PMC
March 2019
11 Reads

Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion Associated With Adenoviral Pneumonia.

Child Neurol Open 2019 5;6:2329048X19826288. Epub 2019 Feb 5.

Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Acute encephalopathy with biphasic seizures and late reduced diffusion is a subtype of acute encephalopathy described in a cohort of Japanese children. Few cases have been reported in countries other than Japan. It is characterized clinically by biphasic seizures and late reduced subcortical diffusion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1177/2329048X19826288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365989PMC
February 2019
1 Read

Incidence of hospitalisation for severe complications of influenza virus infection in Japanese patients between 2012 and 2016: a cross-sectional study using routinely collected administrative data.

BMJ Open 2019 Jan 17;9(1):e024687. Epub 2019 Jan 17.

Department of Health Sciences, University of Yamanashi, Chuo City, Japan.

Objective: To calculate the incidence of hospitalisation due to acute respiratory failure, pneumonia, acute respiratory distress syndrome (ARDS), febrile seizures and encephalitis/encephalopathy among influenza-positive patients in Japan, where point-of-care tests are routinely used to diagnose influenza.

Design: A cross-sectional study using routinely collected data.

Setting: Japanese clinics and hospitals between 2012 and 2016. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02468
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http://dx.doi.org/10.1136/bmjopen-2018-024687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340484PMC
January 2019
3 Reads

Clinical spectrum of -related epileptic disorders.

Neurology 2019 Mar 8;92(11):e1238-e1249. Epub 2019 Feb 8.

From the University of Tübingen (S. Wolking, J.M., Y.G.W., H.L., J.S.), Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, Tübingen, Germany; Luxembourg Centre for Systems Biomedicine (P.M.), University of Luxembourg, Esch-sur-Alzette; Pediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G., C.M.), Children's Hospital Anna Meyer, University of Florence, Italy; Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Services (R.S.M.), University of Southern Denmark, Odense; Department of Clinical and Experimental Epilepsy (S.B.), UCL Institute of Neurology and Epilepsy Society, UK, London; Division of Neurology (K.L.H., I.H.), Children's Hospital of Philadelphia, PA; Department of Pediatric Neurology (C.D.A.), Centre de Compétences Maladies Rares, CHU Besançon; Service de Génétique (N.C.), Hospices Civils des Lyon, Bron; GENDEV Team (N.C.), Neurosciences Research Center of Lyon, Bron, France; Neuropediatric Clinic and Clinic for Neurorehabilitation (K.S.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Beaumont Hospital (P.W.-W.), Dublin, Ireland; Department of Pediatrics, Division of Medical Genetics, Institute of Human Genetics (B.A.M.), Departments of Neurology and Pediatrics (A.N.), and Departments of Neurology and Pediatrics, and Institute of Human Genetics (M.R.C.), University of California, San Francisco; Department of Neurology (W.V.P.), University Hospitals Leuven, Belgium; Department of Pediatrics (L.L.S.), Hvidovre Hospital, Denmark; King's College Hospital (S.O., E.H., S.G., D.K.P.), London; Evelina London Children's Hospital (S.O., E.H., S.G.), London, UK; Section of Genetics (K.B., M.S.S.), Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora; Clinique Bernoise Montana (T.D.), Crans-Montana, Switzerland; Department of Neuropediatrics (H.M.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics (A.T.P., S.J.L.K., J.C.T.) and Department of Oncology (D.V.V.), University of Oxford, UK; Epilepsy Center (M.P.C.), Health Sciences Department, San Paolo Hospital, University of Milan; Child Neuropsychiatry (F.D.), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Italy; Departments of Neurology and Clinical Genomics (R.H.G.) and Health Sciences Research and Clinical Genomics (E.W.K., C.K.), Mayo Clinic, Rochester, MN; Ambry Genetics (Z.P.), Aliso Viejo, CA; Department of Clinical Neuroscience (S.T.), King's College London; New Medicines (M.A., D.M.), UCB Pharma, Slough, UK; Neuropediatric Clinic and Clinic for Neurorehabilitation (G.J.K.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Research Institute for Rehabilitation, Transition and Palliation (G.J.K.), PMU Salzburg, Austria; Department of Neurology (D.H.L.), University of California, San Francisco; Neurogenetics Group (S. Weckhuysen), Center for Molecular Neurology, VIB, Antwerp; Laboratory of Neurogenetics (S. Weckhuysen), Institute Born-Bunge, University of Antwerp; Department of Neurology (S. Weckhuysen), Antwerp University Hospital, Antwerp, Belgium; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (D.K.P.), MRC Centre for Neurodevelopmental Disorders (D.K.P.), King's College London, UK; Evelina London Children's Hospital (D.K.P.), London, UK; Department of Neuropediatrics (I.H.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; Institute of Neuroscience (R.H.T.), Henry Wellcome Building, Newcastle University; Neurology Research Group (M.I.R.), Institute of Life Science, Swansea University Medical School, Swansea, UK; Service de Génétique (G.L.), Hospices Civils des Lyon, Bron; GENDEV Team (G.L.), Neurosciences Research Center of Lyon, Bron, France; NIHR University College London Hospitals Biomedical Research Centre (S.M.S.), UCL Institute of Neurology, London, UK; Cologne Center for Genomics (D.L.), University of Cologne, Germany; Stanley Center for Psychiatric Research (D.L.) and Program in Medical and Population Genetics (D.L.), Broad Institute of MIT and Harvard, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit (D.L.), Massachusetts General Hospital and Harvard Medical School, Boston.

Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to , encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants.

Methods: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007089DOI Listing
March 2019
2 Reads

Systematic review finds that fever phobia is a worldwide issue among caregivers and healthcare providers.

Acta Paediatr 2019 Feb 4. Epub 2019 Feb 4.

Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Aim: Fever phobia describes exaggerated concerns about the consequences of childhood fever and broader awareness is needed in everyday clinical practice. We investigated the factors associated with fever phobia in caregivers and healthcare providers and the geographical distribution of the issue.

Methods: The National Library of Medicine, Excerpta Medica and Google Scholar databases were searched. Read More

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http://dx.doi.org/10.1111/apa.14739DOI Listing
February 2019
5 Reads

Mutations in and in a patient with early-onset epileptic encephalopathy and respiratory depression.

Cold Spring Harb Mol Case Stud 2019 Feb 1;5(1). Epub 2019 Feb 1.

Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

Early infantile epileptic encephalopathy (EIEE) is a severe disorder associated with epilepsy, developmental delay and intellectual disability, and in some cases premature mortality. We report the case of a female infant with EIEE and strikingly suppressed respiratory dysfunction that led to death. Postmortem research evaluation revealed hypoplasia of the arcuate nucleus of the medulla, a candidate region for respiratory regulation. Read More

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http://dx.doi.org/10.1101/mcs.a003442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371743PMC
February 2019
6 Reads

Risk Factors of Recurrence of Febrile Seizures in Children in a Tertiary Care Hospital in Kanpur: A One Year Follow Up Study.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):31-36

Department of Pediatrics, GSVM Medical College, Kanpur, Uttar Pradesh, India.

Background: Febrile seizures are commonly seen in children and about one-third of the children develop a recurrence of febrile seizures.

Objectives: The main objective is to study the risk factors associated with recurrence of febrile seizures in Indian children.

Methods: This prospective, longitudinal study was carried out in the Department of Pediatrics, GSVM Medical College, Kanpur. Read More

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http://dx.doi.org/10.4103/aian.AIAN_472_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327698PMC
January 2019
2 Reads

Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.

Epilepsy Res 2019 02 14;150:66-69. Epub 2019 Jan 14.

Research Institute of the McGill University Health Center, 2155 Guy Street, Montreal, PQ, H3H 2L9, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, PQ, H4A 3J1, Canada.

We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one individual had suffered sudden death, and two families were identified. In Family A, five males had febrile seizures and one girl had febrile seizures plus. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.009DOI Listing
February 2019
5 Reads

Reduced cerebrospinal fluid levels of interleukin-10 in children with febrile seizures.

Seizure 2019 Feb 14;65:94-97. Epub 2019 Jan 14.

Pediatric Emergency Unit, Department of Pediatrics, Okmeydani Training and Research Hospital, Istanbul, Turkey.

Purpose: The exact etiology of febrile seizures (FS) is still unclear. However, it is thought that cytokine network activation may have a causative role. Therefore, this study aimed to evaluate the levels of interleukin-12 (IL-12) as a proinflammatory cytokine, interleukin-10 (IL-10) as an anti-inflammatory cytokine, and interferon-β (IFN-β), a marker of toll-like receptor-3 activation as a host response to viruses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183061
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http://dx.doi.org/10.1016/j.seizure.2019.01.008DOI Listing
February 2019
15 Reads

Neurodevelopmental problems should be considered in children with febrile seizures.

Acta Paediatr 2019 Jan 7. Epub 2019 Jan 7.

Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg and Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

Aim: Clinical developmental phenotyping of four- to five-year-old children with febrile seizures (FSs).

Methods: Children with FS (n = 157, corresponding to 3.7% of the targeted general population of four-five-year-olds) had been identified at child healthcare centres in Gothenburg. Read More

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http://doi.wiley.com/10.1111/apa.14716
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http://dx.doi.org/10.1111/apa.14716DOI Listing
January 2019
9 Reads

Increased von Willebrand factor parameters in children with febrile seizures.

PLoS One 2019 3;14(1):e0210004. Epub 2019 Jan 3.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Introduction: Primary blood coagulation and wound sealing are orchestrated by von Willebrand factor (VWF), a large multimeric glycoprotein. Upon release of arginine vasopressin (AVP), VWF containing high molecular weight multimers is secreted. By measuring copeptin, the C-terminal part of the AVP prohormone, we recently found strongly increased AVP levels in children with febrile seizures (FS) as compared to children with fever but without seizures. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210004PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317815PMC
January 2019
2 Reads

Hemiconvulsion-Hemiplegia-Epilepsy in a girl with cobalamin C deficiency.

Epileptic Disord 2018 Dec;20(6):545-550

Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University,, Department of Neurology and Neurosurgery, McGill University,, Research Institute of the McGill University Health Centre.

Hemiconvulsion-Hemiplegia-Epilepsy initially involves an infantile presentation of febrile focal motor status epilepticus, with subsequent hemiplegia of the initially affected side. Months to years later, affected children go on to develop a chronic epilepsy with recurrent focal seizures which are often refractory to treatment. This uncommon paediatric epilepsy syndrome is poorly understood, with only a very small minority of cases associated with an underlying genetic or metabolic abnormality. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1017DOI Listing
December 2018
8 Reads

Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department.

J Pediatr 2019 Apr 7;207:213-219.e3. Epub 2018 Dec 7.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: To evaluate the proportion of children presenting to the emergency department (ED) with altered mental status who demonstrate nonconvulsive seizures on reduced-lead electroencephalography (EEG), and to further investigate the characteristics, treatment, and outcomes in these patients compared with patients without nonconvulsive seizures.

Study Design: In this retrospective cohort study, we reviewed the database and medical records of pediatric patients (aged <18 years) in a single ED between May 1, 2016, and April 30, 2018. We first determined the proportion of nonconvulsive seizures among patients with altered mental status (Glasgow Coma Scale <15). Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.11.019DOI Listing
April 2019
4 Reads

Electroencephalography in Pediatric Epilepsy.

Indian Pediatr 2018 Oct;55(10):893-901

Department of Pediatrics, BL Kapur Superspeciality Hospital, Delhi; India.

Surface electroencephalography (EEG) is a useful electrophysiological investigation for evaluating a paroxysmal event in children. It measures the electro potential difference between two points on the scalp. It is a non-invasive tool that analyzes neuronal maturation and abnormal cortical excitability. Read More

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October 2018
4 Reads

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2019 Feb 6;205:130-137. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
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http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
February 2019
25 Reads

Implementing Universal Varicella Vaccination in Europe: The Path Forward.

Pediatr Infect Dis J 2019 Feb;38(2):181-188

University of Tampere Medical School, Tampere, Finland.

Varicella is a common vaccine-preventable disease that usually presents as a mild disorder but can lead to severe complications. Before the implementation of universal varicella vaccination (UVV) in some European countries, the burden of varicella disease was broadly similar across the region. Despite this, countries adopted heterogeneous varicella vaccination strategies. Read More

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http://dx.doi.org/10.1097/INF.0000000000002233DOI Listing
February 2019
5 Reads

Myelin water fraction changes in febrile seizures.

Clin Neurol Neurosurg 2018 Dec 10;175:61-67. Epub 2018 Oct 10.

Division of Pediatric Neurosurgery, Joe DiMaggio Children's Hospital, 1150N 35th Ave, Hollywood, FL, 33021, USA. Electronic address:

Objective: The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.

Patients And Methods: As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences-T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)-and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183040
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http://dx.doi.org/10.1016/j.clineuro.2018.10.005DOI Listing
December 2018
6 Reads

Respiratory Syncytial Virus-Associated Seizures in Korean Children during 2011/01 -2016/12.

Korean J Pediatr 2018 Oct 23. Epub 2018 Oct 23.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.

Purpose: : Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that present with seizures.

Methods: : We retrospectively reviewed the medical records of patients aged less than 15 years with laboratory-confirmed RSV infections and seizures between January 2011 and December 2016 in a regional hospital in South Korea. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.07066
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http://dx.doi.org/10.3345/kjp.2018.07066DOI Listing
October 2018
11 Reads

HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.

Brain 2018 Nov;141(11):3160-3178

EuroEPINOMICS RES Consortium.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal excitability and their dysfunction has been linked to epileptogenesis but few individuals with neurological disorders related to variants altering HCN channels have been reported so far. In 2014, we described five individuals with epileptic encephalopathy due to de novo HCN1 variants. To delineate HCN1-related disorders and investigate genotype-phenotype correlations further, we assembled a cohort of 33 unpublished patients with novel pathogenic or likely pathogenic variants: 19 probands carrying 14 different de novo mutations and four families with dominantly inherited variants segregating with epilepsy in 14 individuals, but not penetrant in six additional individuals. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/brain/awy263DOI Listing
November 2018
44 Reads

Assessment of physicians knowledge and attitudes in the management of febrile seizures.

Neurosciences (Riyadh) 2018 Oct;23(4):314-319

Division of Neurology, Department of Pediatrics, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail:

Objective: To assess the knowledge and attitudes of physicians in different specialties who are involved in the care of children with FS.

Methods: We assessed knowledge and attitudes in the management of Febrile seizure (FS) among physicians working in different specialties in the Kingdom of Saudi Arabia using a questionnaire-based cross-sectional study conducted from September-December 2016.

Results: Of the 300 physicians who responded to the questionnaire, 178 (59. Read More

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http://dx.doi.org/10.17712/nsj.2018.4.20180097DOI Listing
October 2018
19 Reads
0.391 Impact Factor

Acute encephalopathy with biphasic seizures and late reduced diffusion accompanied by Takotsubo cardiomyopathy.

Brain Dev 2019 Mar 13;41(3):305-309. Epub 2018 Oct 13.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is characterized by biphasic seizures and impaired consciousness. Takotsubo cardiomyopathy (TTC), which is typically triggered by psychological or physical stress, is characterized by transient myocardial dysfunction affecting the left ventricular apex. Recent reports have suggested that seizures can also trigger TTC. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.10.002DOI Listing
March 2019
3 Reads

The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.

Sci Rep 2018 Oct 11;8(1):15123. Epub 2018 Oct 11.

Department of pediatrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Foshan, Guangdong, 528000, China.

Systemic inflammatory response has been implicated as a contributor to the onset of febrile seizures (FS). The four novel indices of the inflammatory response such as, neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet count (PLT) ratio and red blood cell distribution width (RDW) have been investigated in FS susceptibility and FS types (simple febrile seizure and complex febrile seizure). However, the potential role of these inflammatory markers and MPV/PLT ratio (MPR) in Chinese children with FS has yet to be fully determined. Read More

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http://www.nature.com/articles/s41598-018-33373-3
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http://dx.doi.org/10.1038/s41598-018-33373-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181908PMC
October 2018
3 Reads

Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode.

Pediatrics 2018 Nov 8;142(5). Epub 2018 Oct 8.

Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan.

Objectives: To confirm the safety of using acetaminophen for febrile seizures (FSs) and to assess its efficacy in preventing FS recurrence during the same fever episode.

Methods: In this single-center, prospective, open, randomized controlled study, we included children and infants (age range: 6-60 months) with FSs who visited our hospital between May 1, 2015, and April 30, 2017. The effectiveness of acetaminophen was examined by comparing the recurrence rates of patients in whom rectal acetaminophen (10 mg/kg) was administered every 6 hours until 24 hours after the first convulsion (if the fever remained >38. Read More

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http://dx.doi.org/10.1542/peds.2018-1009DOI Listing
November 2018
4 Reads

Fangjing decoction relieves febrile seizures-induced hippocampal neuron apoptosis in rats via regulating the Akt/mTOR pathway.

Biosci Rep 2018 10 31;38(5). Epub 2018 Oct 31.

Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou 310002, China.

: Fangjing decoction is a Traditional Chinese Medicine that exhibits anticonvulsive effects in treating febrile seizures (FS). Its action mechanism and the regulation on Akt/mammalian target of rapamycin (mTOR) pathway were revealed in the present study.: FS model was established in Sprague-Dawley rats with or without Fangjing decoction treatment. Read More

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http://dx.doi.org/10.1042/BSR20181206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209604PMC
October 2018
1 Read

Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?

Epilepsia 2018 11 6;59(11):2005-2018. Epub 2018 Sep 6.

Department of Anatomy/Neurobiology, University of California, Irvine, Irvine, California.

Objective: A subset of children with febrile status epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a noninvasive predictive marker of those at risk that can be identified soon after FSE, within a clinically realistic timeframe.

Methods: Longitudinal T -weighted magnetic resonance imaging (T WI MRI) of rat pups at several time points after experimental FSE (eFSE) was performed on a high-field scanner followed by long-term continuous electroencephalography. Read More

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http://dx.doi.org/10.1111/epi.14561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217797PMC
November 2018
7 Reads

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study).

Hum Vaccin Immunother 2019 5;15(2):496-502. Epub 2018 Oct 5.

p Faculty of Medicine, Department of Pediatrics , Eskisehir Osmangazi University , Eskisehir , Turkey.

Background: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. Read More

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http://dx.doi.org/10.1080/21645515.2018.1526588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422444PMC
October 2018
12 Reads
2.131 Impact Factor

National registry of patients with Fukuyama congenital muscular dystrophy in Japan.

Neuromuscul Disord 2018 Oct 10;28(10):885-893. Epub 2018 Aug 10.

Department of Pediatrics, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan; The Japan Muscular Dystrophy Association, Tokyo, Japan.

Fukuyama congenital muscular dystrophy (FCMD) is the second most common form of muscular dystrophy in the Japanese population and is caused by mutations in the fukutin (FKTN) gene. In 2011, the Japan Muscular Dystrophy Association (JMDA) developed a nationwide registry of genetically confirmed patients with FCMD. We retrospectively reviewed the registry dataset of patients with FCMD to obtain data, including age, sex, developmental milestones, intellectual level, complications, and primary treatments. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.08.001DOI Listing
October 2018
5 Reads
2.640 Impact Factor

Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis.

Epidemiol Infect 2018 Sep 13:1-6. Epub 2018 Sep 13.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System,Singapore,Singapore.

Febrile seizure (FS) in children is a common complication of infections with respiratory viruses and hand, foot and mouth disease (HFMD). We conducted a retrospective ecological time-series analysis to determine the temporal relationship between hospital attendances for FS and HFMD or respiratory virus infections. Epilepsy attendance was used as a control. Read More

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http://dx.doi.org/10.1017/S0950268818002509DOI Listing
September 2018
9 Reads

Ptosis in childhood: A clinical sign of several disorders: Case series reports and literature review.

Medicine (Baltimore) 2018 Sep;97(36):e12124

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Blepharoptosis (ptosis) is a common but often overlooked sign that may serve as a sign/manifestation of other conditions, ranging from a mild and purely cosmetic presentation to a severe and occasionally progressive disorder. Ptosis may show an acute onset or may manifest as a chronic disorder. Its presentation may vary: unilateral versus bilateral, progressive versus non-progressive, isolated versus complex which occurs in association with other symptoms, and congenital versus acquired (often concomitant with neuromuscular disorders). Read More

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http://dx.doi.org/10.1097/MD.0000000000012124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133583PMC
September 2018
6 Reads

Risk of low serum levels of ionized magnesium in children with febrile seizure.

BMC Pediatr 2018 Sep 7;18(1):297. Epub 2018 Sep 7.

Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea.

Background: Suboptimal intake of magnesium become prevalent due to the modern diet of processed food low in magnesium. Magnesium may modulate seizure activity by antagonizing excitatory calcium influx through the N-methyl-D-aspartate receptor. Although hyponatremia has been reported to be common in febrile seizures, the most common form of seizure, little is known about the status of serum ionized magnesium. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-018-1271-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128998PMC
September 2018
21 Reads

Optimal Doses of H1 Antihistamines Do Not Increase Susceptibility to Febrile Convulsions in Children.

Pediatr Neurol 2018 Oct 18;87:42-47. Epub 2018 May 18.

Department of Pediatrics, National Hospital Organization Beppu Medical Center, Oita, Japan. Electronic address:

Background: The purpose of this study was to elucidate whether H1 antihistamine administration increases susceptibility to febrile convulsions in children.

Methods: A single-center, retrospective observational study was conducted in Japan. The study included 380 children with febrile convulsions between the ages of six months and five years transported via ambulance from 2011 through 2016. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.04.013DOI Listing
October 2018
3 Reads

Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study.

Seizure 2018 Oct 27;61:164-169. Epub 2018 Aug 27.

Children's Hospital, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Purpose: Trends of epilepsy in children were correlated with febrile seizure (FS) in a previous retrospective study. In the present study, the authors obtained relevant data from a nationwide cohort database to investigate trends in subsequent epilepsy in children with a history of recurrent FS.

Methods: A total of 10,210 children with FS comprised the cohort. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.08.019DOI Listing
October 2018
5 Reads

National survey of factors associated with repeated admissions due to febrile seizure.

Seizure 2018 Oct 13;61:149-152. Epub 2018 Aug 13.

Division of Pediatric Neurology, Department of Pediatrics, UCLA Medical Center, LA, CA, USA.

Purpose: Several studies reported recent trends in febrile seizure (FS) in terms of prevalence, incidence, and hospitalization rates at a national level in the USA. However, no studies have revealed risk factors for repeated admissions due to FS.

Method: We extracted discharge records of patients with FS aged < 6 years for the years 2010-14 using the Nationwide Readmission. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.08.013DOI Listing
October 2018
3 Reads

Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus.

Brain Dev 2018 Nov 23;40(10):884-890. Epub 2018 Aug 23.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Fosphenytoin (fPHT) and continuous intravenous midazolam (cMDL) had commonly been used as second-line treatments for pediatric status epilepticus (SE) in Japan. However, there is no comparative study of these two treatments.

Methods: We included consecutive children who 1) were admitted to Kobe Children's Hospital because of convulsion with fever and 2) were treated with either fPHT or cMDL as second-line treatment for convulsive SE lasting for longer than 30 min. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183039
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http://dx.doi.org/10.1016/j.braindev.2018.08.001DOI Listing
November 2018
27 Reads

Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats.

Neurobiol Dis 2018 Nov 16;119:172-189. Epub 2018 Aug 16.

Alberta Children's Hospital Research Institute, Department of Pediatrics, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. Electronic address:

Thermal hyperpnea, a pattern of breathing during hyperthermia that is characterized by an increase in tidal volume as well as breathing frequency, is known to lead to respiratory alkalosis. Thermal hyperpnea-induced respiratory alkalosis is linked to febrile seizures (FS). The heat-sensitive transient receptor potential vanilloid-1 (TRPV1) receptors are localized in, and implicated in the heat sensitivity of peripheral and central structures involved in the respiratory response to hyperthermia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183041
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http://dx.doi.org/10.1016/j.nbd.2018.08.004DOI Listing
November 2018
15 Reads

Mesial Temporal Sclerosis in SCN1A-Related Epilepsy: Two Long-Term EEG Case Studies.

Clin EEG Neurosci 2018 Aug 17:1550059418794347. Epub 2018 Aug 17.

1 Department of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr von Haunersches Children's Hospital, University of Munich, Munich, Germany.

Patients with temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS) are eligible candidates for resective epilepsy surgery. We report on 2 male patients aged 4 years with suspected TLE due to MTS who were referred for presurgical evaluation. Both patients came to medical attention within the first year of life suffering from febrile status epileptici and subsequent unprovoked seizures. Read More

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http://journals.sagepub.com/doi/10.1177/1550059418794347
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http://dx.doi.org/10.1177/1550059418794347DOI Listing
August 2018
32 Reads

Acute Leukoencephalopathy with Restricted Diffusion.

Authors:
Mahesh Kamate

Indian J Crit Care Med 2018 Jul;22(7):519-523

Department of Pediatrics, JN Medical College, KLE University, Belgaum, Karnataka, India.

Treatment and outcome of children with acute encephalopathy depend on the cause, prompt treatment of the underlying cause, and use of adequate supportive measures. Many novel causes of acute encephalopathy are emerging where lumbar puncture, computed tomography of the head, and routine biochemical testing can be normal such as acute disseminated encephalomyelitis and febrile infection-related refractory epilepsy syndrome. Magnetic resonance imaging (MRI) plays an important role in the workup of children with acute leukoencephalopathy. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069315PMC
July 2018
3 Reads

Sociodemographic risk factors for febrile seizures: A school-based study from Izmir, Turkey.

Seizure 2018 Oct 25;61:45-49. Epub 2018 Jul 25.

Dokuz Eylül University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, İzmir, Turkey.

Purpose: Despite the fact that socioeconomic and environmental factors of a population are changing over time, there are few studies focusing on the effects of sociodemographic factors on the prevalence of febrile seizures (FS). This study was designed to find out the prevalence of FS and to investigate the effect of socio-cultural and economic factors on this prevalence among the Turkish school children.

Methods: A school-based, cross-sectional study was conducted in first and second-class children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183020
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http://dx.doi.org/10.1016/j.seizure.2018.07.019DOI Listing
October 2018
12 Reads

Genetic literacy series: genetic epilepsy with febrile seizures plus.

Epileptic Disord 2018 Aug;20(4):232-238

Epilepsy Research Centre, Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria.

Genetic epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome in which affected individuals within a family typically have a variety of epilepsy phenotypes, varying from simple febrile seizures and febrile seizures plus with a good outcome to severe epileptic encephalopathies. Here, we review the spectrum of epilepsy phenotypes, the genetic architecture of GEFS+, and the implicated genes. Using an illustrative clinical case study, we describe important steps in managing patients with GEFS+: making the diagnosis of GEFS+, appropriate genetic testing, and counselling. Read More

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http://dx.doi.org/10.1684/epd.2018.0985DOI Listing
August 2018
5 Reads