1,159 results match your criteria Pediatrics Febrile Seizures


Hemiconvulsion-Hemiplegia-Epilepsy in a girl with cobalamin C deficiency.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University,, Department of Neurology and Neurosurgery, McGill University,, Research Institute of the McGill University Health Centre.

Hemiconvulsion-Hemiplegia-Epilepsy initially involves an infantile presentation of febrile focal motor status epilepticus, with subsequent hemiplegia of the initially affected side. Months to years later, affected children go on to develop a chronic epilepsy with recurrent focal seizures which are often refractory to treatment. This uncommon paediatric epilepsy syndrome is poorly understood, with only a very small minority of cases associated with an underlying genetic or metabolic abnormality. Read More

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http://dx.doi.org/10.1684/epd.2018.1017DOI Listing
December 2018

Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department.

J Pediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: To evaluate the proportion of children presenting to the emergency department (ED) with altered mental status who demonstrate nonconvulsive seizures on reduced-lead electroencephalography (EEG), and to further investigate the characteristics, treatment, and outcomes in these patients compared with patients without nonconvulsive seizures.

Study Design: In this retrospective cohort study, we reviewed the database and medical records of pediatric patients (aged <18 years) in a single ED between May 1, 2016, and April 30, 2018. We first determined the proportion of nonconvulsive seizures among patients with altered mental status (Glasgow Coma Scale <15). Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.11.019DOI Listing
December 2018

Electroencephalography in Pediatric Epilepsy.

Indian Pediatr 2018 Oct;55(10):893-901

Department of Pediatrics, BL Kapur Superspeciality Hospital, Delhi; India.

Surface electroencephalography (EEG) is a useful electrophysiological investigation for evaluating a paroxysmal event in children. It measures the electro potential difference between two points on the scalp. It is a non-invasive tool that analyzes neuronal maturation and abnormal cortical excitability. Read More

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October 2018
2 Reads

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
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http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
November 2018
7 Reads

Implementing Universal Varicella Vaccination in Europe: The Path Forward.

Pediatr Infect Dis J 2018 Nov 7. Epub 2018 Nov 7.

University of Tampere Medical School, Biokatu 10, 33014, Tampere, Finland.

Varicella is a common vaccine-preventable disease that usually presents as a mild disorder but can lead to severe complications. Before the implementation of universal varicella vaccination (UVV) in some European countries, the burden of varicella disease was broadly similar across the region. Despite this, countries adopted heterogeneous varicella vaccination strategies. Read More

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http://dx.doi.org/10.1097/INF.0000000000002233DOI Listing
November 2018
3 Reads

Myelin water fraction changes in febrile seizures.

Clin Neurol Neurosurg 2018 Dec 10;175:61-67. Epub 2018 Oct 10.

Division of Pediatric Neurosurgery, Joe DiMaggio Children's Hospital, 1150N 35th Ave, Hollywood, FL, 33021, USA. Electronic address:

Objective: The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.

Patients And Methods: As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences-T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)-and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183040
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http://dx.doi.org/10.1016/j.clineuro.2018.10.005DOI Listing
December 2018
3 Reads

Respiratory Syncytial Virus-Associated Seizures in Korean Children during 2011/01 -2016/12.

Korean J Pediatr 2018 Oct 23. Epub 2018 Oct 23.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, Republic of Korea.

Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that are presented with seizures.

Methods: We retrospectively reviewed the medical records of patients younger than 15 years who had laboratory-confirmed RSV infections and seizures from January 2011 to December 2016 in a regional hospital in South Korea. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.07066
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http://dx.doi.org/10.3345/kjp.2018.07066DOI Listing
October 2018
1 Read

HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.

Brain 2018 Nov;141(11):3160-3178

EuroEPINOMICS RES Consortium.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal excitability and their dysfunction has been linked to epileptogenesis but few individuals with neurological disorders related to variants altering HCN channels have been reported so far. In 2014, we described five individuals with epileptic encephalopathy due to de novo HCN1 variants. To delineate HCN1-related disorders and investigate genotype-phenotype correlations further, we assembled a cohort of 33 unpublished patients with novel pathogenic or likely pathogenic variants: 19 probands carrying 14 different de novo mutations and four families with dominantly inherited variants segregating with epilepsy in 14 individuals, but not penetrant in six additional individuals. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/brain/awy263DOI Listing
November 2018
11 Reads

Assessment of physicians knowledge and attitudes in the management of febrile seizures.

Neurosciences (Riyadh) 2018 Oct;23(4):314-319

Division of Neurology, Department of Pediatrics, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail:

Objective: To assess the knowledge and attitudes of physicians in different specialties who are involved in the care of children with FS.

Methods: We assessed knowledge and attitudes in the management of Febrile seizure (FS) among physicians working in different specialties in the Kingdom of Saudi Arabia using a questionnaire-based cross-sectional study conducted from September-December 2016.

Results: Of the 300 physicians who responded to the questionnaire, 178 (59. Read More

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October 2018
8 Reads

Acute encephalopathy with biphasic seizures and late reduced diffusion accompanied by Takotsubo cardiomyopathy.

Brain Dev 2018 Oct 13. Epub 2018 Oct 13.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is characterized by biphasic seizures and impaired consciousness. Takotsubo cardiomyopathy (TTC), which is typically triggered by psychological or physical stress, is characterized by transient myocardial dysfunction affecting the left ventricular apex. Recent reports have suggested that seizures can also trigger TTC. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.10.002DOI Listing
October 2018
1 Read

The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.

Sci Rep 2018 Oct 11;8(1):15123. Epub 2018 Oct 11.

Department of pediatrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Foshan, Guangdong, 528000, China.

Systemic inflammatory response has been implicated as a contributor to the onset of febrile seizures (FS). The four novel indices of the inflammatory response such as, neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet count (PLT) ratio and red blood cell distribution width (RDW) have been investigated in FS susceptibility and FS types (simple febrile seizure and complex febrile seizure). However, the potential role of these inflammatory markers and MPV/PLT ratio (MPR) in Chinese children with FS has yet to be fully determined. Read More

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http://www.nature.com/articles/s41598-018-33373-3
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http://dx.doi.org/10.1038/s41598-018-33373-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181908PMC
October 2018
2 Reads

Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode.

Pediatrics 2018 Nov 8;142(5). Epub 2018 Oct 8.

Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan.

Objectives: To confirm the safety of using acetaminophen for febrile seizures (FSs) and to assess its efficacy in preventing FS recurrence during the same fever episode.

Methods: In this single-center, prospective, open, randomized controlled study, we included children and infants (age range: 6-60 months) with FSs who visited our hospital between May 1, 2015, and April 30, 2017. The effectiveness of acetaminophen was examined by comparing the recurrence rates of patients in whom rectal acetaminophen (10 mg/kg) was administered every 6 hours until 24 hours after the first convulsion (if the fever remained >38. Read More

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http://dx.doi.org/10.1542/peds.2018-1009DOI Listing
November 2018
2 Reads

Fangjing decoction relieves febrile seizures-induced hippocampal neuron apoptosis in rats via regulating the Akt/mTOR pathway.

Biosci Rep 2018 Oct 31;38(5). Epub 2018 Oct 31.

Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou 310002, China.

: Fangjing decoction is a Traditional Chinese Medicine that exhibits anticonvulsive effects in treating febrile seizures (FS). Its action mechanism and the regulation on Akt/mammalian target of rapamycin (mTOR) pathway were revealed in the present study.: FS model was established in Sprague-Dawley rats with or without Fangjing decoction treatment. Read More

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http://dx.doi.org/10.1042/BSR20181206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209604PMC
October 2018

Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?

Epilepsia 2018 Nov 6;59(11):2005-2018. Epub 2018 Sep 6.

Department of Anatomy/Neurobiology, University of California, Irvine, Irvine, California.

Objective: A subset of children with febrile status epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a noninvasive predictive marker of those at risk that can be identified soon after FSE, within a clinically realistic timeframe.

Methods: Longitudinal T -weighted magnetic resonance imaging (T WI MRI) of rat pups at several time points after experimental FSE (eFSE) was performed on a high-field scanner followed by long-term continuous electroencephalography. Read More

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http://dx.doi.org/10.1111/epi.14561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217797PMC
November 2018
4 Reads

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study).

Hum Vaccin Immunother 2018 Sep 20:1-7. Epub 2018 Sep 20.

p Faculty of Medicine, Department of Pediatrics , Eskisehir Osmangazi University , Eskisehir , Turkey.

Background: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. Read More

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http://dx.doi.org/10.1080/21645515.2018.1526588DOI Listing
September 2018
4 Reads

National registry of patients with Fukuyama congenital muscular dystrophy in Japan.

Neuromuscul Disord 2018 Oct 10;28(10):885-893. Epub 2018 Aug 10.

Department of Pediatrics, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan; The Japan Muscular Dystrophy Association, Tokyo, Japan.

Fukuyama congenital muscular dystrophy (FCMD) is the second most common form of muscular dystrophy in the Japanese population and is caused by mutations in the fukutin (FKTN) gene. In 2011, the Japan Muscular Dystrophy Association (JMDA) developed a nationwide registry of genetically confirmed patients with FCMD. We retrospectively reviewed the registry dataset of patients with FCMD to obtain data, including age, sex, developmental milestones, intellectual level, complications, and primary treatments. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.08.001DOI Listing
October 2018
1 Read
2.640 Impact Factor

Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis.

Epidemiol Infect 2018 Sep 13:1-6. Epub 2018 Sep 13.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System,Singapore,Singapore.

Febrile seizure (FS) in children is a common complication of infections with respiratory viruses and hand, foot and mouth disease (HFMD). We conducted a retrospective ecological time-series analysis to determine the temporal relationship between hospital attendances for FS and HFMD or respiratory virus infections. Epilepsy attendance was used as a control. Read More

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http://dx.doi.org/10.1017/S0950268818002509DOI Listing
September 2018
7 Reads

Ptosis in childhood: A clinical sign of several disorders: Case series reports and literature review.

Medicine (Baltimore) 2018 Sep;97(36):e12124

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Blepharoptosis (ptosis) is a common but often overlooked sign that may serve as a sign/manifestation of other conditions, ranging from a mild and purely cosmetic presentation to a severe and occasionally progressive disorder. Ptosis may show an acute onset or may manifest as a chronic disorder. Its presentation may vary: unilateral versus bilateral, progressive versus non-progressive, isolated versus complex which occurs in association with other symptoms, and congenital versus acquired (often concomitant with neuromuscular disorders). Read More

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http://dx.doi.org/10.1097/MD.0000000000012124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133583PMC
September 2018
1 Read

Risk of low serum levels of ionized magnesium in children with febrile seizure.

BMC Pediatr 2018 Sep 7;18(1):297. Epub 2018 Sep 7.

Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea.

Background: Suboptimal intake of magnesium become prevalent due to the modern diet of processed food low in magnesium. Magnesium may modulate seizure activity by antagonizing excitatory calcium influx through the N-methyl-D-aspartate receptor. Although hyponatremia has been reported to be common in febrile seizures, the most common form of seizure, little is known about the status of serum ionized magnesium. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-018-1271-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128998PMC
September 2018
10 Reads

Optimal Doses of H1 Antihistamines Do Not Increase Susceptibility to Febrile Convulsions in Children.

Pediatr Neurol 2018 Oct 18;87:42-47. Epub 2018 May 18.

Department of Pediatrics, National Hospital Organization Beppu Medical Center, Oita, Japan. Electronic address:

Background: The purpose of this study was to elucidate whether H1 antihistamine administration increases susceptibility to febrile convulsions in children.

Methods: A single-center, retrospective observational study was conducted in Japan. The study included 380 children with febrile convulsions between the ages of six months and five years transported via ambulance from 2011 through 2016. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.04.013DOI Listing
October 2018
1 Read

Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study.

Seizure 2018 Oct 27;61:164-169. Epub 2018 Aug 27.

Children's Hospital, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Purpose: Trends of epilepsy in children were correlated with febrile seizure (FS) in a previous retrospective study. In the present study, the authors obtained relevant data from a nationwide cohort database to investigate trends in subsequent epilepsy in children with a history of recurrent FS.

Methods: A total of 10,210 children with FS comprised the cohort. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.08.019DOI Listing
October 2018
1 Read

National survey of factors associated with repeated admissions due to febrile seizure.

Seizure 2018 Oct 13;61:149-152. Epub 2018 Aug 13.

Division of Pediatric Neurology, Department of Pediatrics, UCLA Medical Center, LA, CA, USA.

Purpose: Several studies reported recent trends in febrile seizure (FS) in terms of prevalence, incidence, and hospitalization rates at a national level in the USA. However, no studies have revealed risk factors for repeated admissions due to FS.

Method: We extracted discharge records of patients with FS aged < 6 years for the years 2010-14 using the Nationwide Readmission. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.08.013DOI Listing
October 2018
1 Read

Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus.

Brain Dev 2018 Nov 23;40(10):884-890. Epub 2018 Aug 23.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Fosphenytoin (fPHT) and continuous intravenous midazolam (cMDL) had commonly been used as second-line treatments for pediatric status epilepticus (SE) in Japan. However, there is no comparative study of these two treatments.

Methods: We included consecutive children who 1) were admitted to Kobe Children's Hospital because of convulsion with fever and 2) were treated with either fPHT or cMDL as second-line treatment for convulsive SE lasting for longer than 30 min. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183039
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http://dx.doi.org/10.1016/j.braindev.2018.08.001DOI Listing
November 2018
16 Reads

Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats.

Neurobiol Dis 2018 Nov 16;119:172-189. Epub 2018 Aug 16.

Alberta Children's Hospital Research Institute, Department of Pediatrics, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. Electronic address:

Thermal hyperpnea, a pattern of breathing during hyperthermia that is characterized by an increase in tidal volume as well as breathing frequency, is known to lead to respiratory alkalosis. Thermal hyperpnea-induced respiratory alkalosis is linked to febrile seizures (FS). The heat-sensitive transient receptor potential vanilloid-1 (TRPV1) receptors are localized in, and implicated in the heat sensitivity of peripheral and central structures involved in the respiratory response to hyperthermia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183041
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http://dx.doi.org/10.1016/j.nbd.2018.08.004DOI Listing
November 2018
8 Reads

Mesial Temporal Sclerosis in SCN1A-Related Epilepsy: Two Long-Term EEG Case Studies.

Clin EEG Neurosci 2018 Aug 17:1550059418794347. Epub 2018 Aug 17.

1 Department of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr von Haunersches Children's Hospital, University of Munich, Munich, Germany.

Patients with temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS) are eligible candidates for resective epilepsy surgery. We report on 2 male patients aged 4 years with suspected TLE due to MTS who were referred for presurgical evaluation. Both patients came to medical attention within the first year of life suffering from febrile status epileptici and subsequent unprovoked seizures. Read More

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http://journals.sagepub.com/doi/10.1177/1550059418794347
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http://dx.doi.org/10.1177/1550059418794347DOI Listing
August 2018
18 Reads

Acute Leukoencephalopathy with Restricted Diffusion.

Authors:
Mahesh Kamate

Indian J Crit Care Med 2018 Jul;22(7):519-523

Department of Pediatrics, JN Medical College, KLE University, Belgaum, Karnataka, India.

Treatment and outcome of children with acute encephalopathy depend on the cause, prompt treatment of the underlying cause, and use of adequate supportive measures. Many novel causes of acute encephalopathy are emerging where lumbar puncture, computed tomography of the head, and routine biochemical testing can be normal such as acute disseminated encephalomyelitis and febrile infection-related refractory epilepsy syndrome. Magnetic resonance imaging (MRI) plays an important role in the workup of children with acute leukoencephalopathy. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069315PMC
July 2018
2 Reads

Sociodemographic risk factors for febrile seizures: A school-based study from Izmir, Turkey.

Seizure 2018 Oct 25;61:45-49. Epub 2018 Jul 25.

Dokuz Eylül University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, İzmir, Turkey.

Purpose: Despite the fact that socioeconomic and environmental factors of a population are changing over time, there are few studies focusing on the effects of sociodemographic factors on the prevalence of febrile seizures (FS). This study was designed to find out the prevalence of FS and to investigate the effect of socio-cultural and economic factors on this prevalence among the Turkish school children.

Methods: A school-based, cross-sectional study was conducted in first and second-class children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183020
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http://dx.doi.org/10.1016/j.seizure.2018.07.019DOI Listing
October 2018
8 Reads

Genetic literacy series: genetic epilepsy with febrile seizures plus.

Epileptic Disord 2018 Aug;20(4):232-238

Epilepsy Research Centre, Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria.

Genetic epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome in which affected individuals within a family typically have a variety of epilepsy phenotypes, varying from simple febrile seizures and febrile seizures plus with a good outcome to severe epileptic encephalopathies. Here, we review the spectrum of epilepsy phenotypes, the genetic architecture of GEFS+, and the implicated genes. Using an illustrative clinical case study, we describe important steps in managing patients with GEFS+: making the diagnosis of GEFS+, appropriate genetic testing, and counselling. Read More

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http://dx.doi.org/10.1684/epd.2018.0985DOI Listing
August 2018
3 Reads

The effects of antihistamines on the semiology of febrile seizures.

Brain Dev 2019 Jan 29;41(1):72-76. Epub 2018 Jul 29.

Department of Pediatrics, Aichi Medical University, Nagakute, Aichi, Japan. Electronic address:

Objective: The aim of this study was to clarify the effects of antihistamines on the semiology of febrile seizures.

Methods: The manifestations of febrile seizures were recorded using a structured questionnaire immediately after patients arrived at the hospital. We focused on events at seizure commencement, including changes in behavior and facial expression, and ocular and oral symptoms. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.07.005DOI Listing
January 2019
2 Reads

Febrile seizures: an overview.

Drugs Context 2018 16;7:212536. Epub 2018 Jul 16.

Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Background: Febrile seizures are the most common neurologic disorder in childhood. Physicians should be familiar with the proper evaluation and management of this common condition.

Objective: To provide an update on the current understanding, evaluation, and management of febrile seizures. Read More

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http://dx.doi.org/10.7573/dic.212536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052913PMC
July 2018
11 Reads

Children infected by human herpesvirus 6B with febrile seizures are more likely to develop febrile status epilepticus: A case-control study in a referral hospital in Zambia.

J Med Virol 2018 Nov 13;90(11):1757-1764. Epub 2018 Aug 13.

HerpeZ, University Teaching Hospital, Lusaka, Zambia.

Background: Human herpesvirus 6B (HHV-6B) is the causative agent of Roseola infantum, and has also been suggested to play a role in the pathogenesis of febrile seizures in young children, a percentage of whom go on to develop febrile status epilepticus (FSE), but the existing data is conflicting and inconclusive. HHV-6A is a distinct species, rarely detected in most parts of the world, but prior studies suggest a higher prevalence in febrile African children. We describe a case-control study comparing the frequency of HHV-6A and/or HHV-6B infections in children with febrile seizures (including FSE) and a control group of febrile children without seizures. Read More

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http://dx.doi.org/10.1002/jmv.25269DOI Listing
November 2018
4 Reads
2.350 Impact Factor

[Phenotype study of SCN2A gene related epilepsy].

Zhonghua Er Ke Za Zhi 2018 Jul;56(7):518-523

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize the phenotype of epileptic children with SCN2A mutations. Epileptic patients who were treated in the Pediatric Department of Peking University First Hospital from September 2006 to October 2017 and detected with SCN2A mutations by targeted next-generation sequencing were enrolled. Clinical manifestations of all patients were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.07.009DOI Listing
July 2018
5 Reads

An evidence-based approach to evaluation and management of the febrile child in Indian emergency department.

Int J Crit Illn Inj Sci 2018 Apr-Jun;8(2):63-72

Department of Emergency Medicine, University of Florida, Jacksonville, FL, USA.

Fever is the most common complaint for a child to visit hospital. Under the aegis of INDO-US Emergency and Trauma Collaborative, Pediatric Emergency Medicine chapter of Academic College of Emergency Experts in India developed evidence-based consensus for evaluation and management of febrile child in emergency department. An extensive literature search and further online communication of the group led to the development of a detailed approach for the evaluation and management of individual conditions associated with fever. Read More

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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_3_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018255PMC
July 2018
7 Reads

De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy.

Brain 2018 Jun 28. Epub 2018 Jun 28.

Department of Human Genetics, Emory University, Atlanta, Georgia, 30322, USA.

GABAA receptors are ligand-gated anion channels that are important regulators of neuronal inhibition. Mutations in several genes encoding receptor subunits have been identified in patients with various types of epilepsy, ranging from mild febrile seizures to severe epileptic encephalopathy. Using whole-genome sequencing, we identified a novel de novo missense variant in GABRA5 (c. Read More

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http://dx.doi.org/10.1093/brain/awy171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061692PMC
June 2018
3 Reads

Metabolic profile of oxidative stress and trace elements in febrile seizures among children.

Metab Brain Dis 2018 Oct 9;33(5):1509-1515. Epub 2018 Jun 9.

Department of Pediatrics, Faculty of Medicine Al-Azhar University (Assiut Branch), Assiut, Egypt.

Febrile seizures (FS) are frequent convulsive disorders, occurring in infants and young children. The present study aims to assess and compare the serum levels of oxidative stress markers and some essential trace minerals in FS with normal or abnormal EEG and evaluate the effect of antioxidant therapy on the clinical outcome. This study has been carried out on 80 children with FS (40 with simple FS and 40 with complex FS) and 40 febrile children without seizures. Read More

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http://dx.doi.org/10.1007/s11011-018-0258-7DOI Listing
October 2018
2 Reads

Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study.

Ital J Pediatr 2018 Jun 15;44(1):70. Epub 2018 Jun 15.

Department of Pediatrics, Chinese PLA General Hospital, Beijing, 100853, China.

Background: In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge.

Methods: Patients with frequent FS were assigned to undergo Electroencephalogram (EEG). Read More

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http://dx.doi.org/10.1186/s13052-018-0507-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003147PMC
June 2018
9 Reads

[Study of GRIN2A mutation in epilepsy-aphasia spectrum disorders].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Jun;35(3):314-318

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

Objective: To detect potential mutations of the glutamate receptor subunit (GRIN2A) gene and delineate the clinical-genetic characteristics of patients with epilepsy-aphasia spectrum (EAS) disorders.

Methods: One hundred twenty two patients with Landau-Kleffner syndrome (LKS), epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS), benign childhood epilepsy with centrotemporal spikes (BECT) and BECT variants were recruited. Potential mutations of the GRIN2A gene were screened with Sanger sequencing. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2018.03.002DOI Listing
June 2018
29 Reads

Differential diagnosis of nonepileptic twilight state with convulsive manifestations after febrile seizures.

Brain Dev 2018 Oct 14;40(9):781-785. Epub 2018 Jun 14.

Department of Pediatrics, Kurashiki Central Hospital, Japan.

Background: Nonepileptic twilight state with convulsive manifestations (NETC) is a nonepileptic state following a febrile seizure (FS), which may be misdiagnosed as a prolonged seizure and result in overtreatment. We aimed to describe clinical manifestations of NETC and to determine characteristics that are helpful to distinguish NETC from other pathological conditions.

Methods: We conducted a retrospective chart review from January 2010 to December 2016 and selected the patients who presented with symptoms resembling status epilepticus with fever and a confirmed diagnosis using an electroencephalogram (EEG). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183022
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http://dx.doi.org/10.1016/j.braindev.2018.05.014DOI Listing
October 2018
3 Reads

Hemiconvulsion Hemiplegia Syndrome in a young boy with developmental delay.

J Pak Med Assoc 2018 Apr;68(4):656-659

Department of Neurology, Shifa International Hospital, Islamabad.

Hemiconvulsion hemiplegia epilepsy (HHE) syndrome is a rare complication of prolonged focal seizures in children upto 4 years of age. It is usually idiopathic and seen in the setting of febrile seizures in otherwise normal children but less commonly is also associated with structural, infective, traumatic and degenerative diseases that predispose to seizures. It has 3 stages, the first of prolonged focal seizures, then the development of hemiplegia and then followed by final stage of development of epilepsy after a variable latent period. Read More

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April 2018
5 Reads

Benign and severe early-life seizures: a round in the first year of life.

Ital J Pediatr 2018 May 15;44(1):54. Epub 2018 May 15.

University-Hospital 'Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy.

Background: At the onset, differentiation between abnormal non-epileptic movements, and epileptic seizures presenting in early life is difficult as is clinical diagnosis and prognostic evaluation of the various seizure disorders presenting at this age. Seizures starting in the first year of life including the neonatal period might have a favorable course, such as in infants presenting with benign familial neonatal epilepsy, febrile seizures simplex or acute symptomatic seizures. However, in some cases, the onset of seizures at birth or in the first months of life have a dramatic evolution with severe cerebral impairment. Read More

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http://dx.doi.org/10.1186/s13052-018-0491-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952424PMC

Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.

Recent Pat Inflamm Allergy Drug Discov 2018 ;12(2):128-135

Department of Pediatrics, Division of Child Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, United States.

Background: New-Onset Refractory Status Epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile Infection-Related Epilepsy Syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient. The literature on FIRES is scarce. Read More

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http://dx.doi.org/10.2174/1872213X12666180508122450DOI Listing
December 2018
3 Reads
1 Citation

Dynamic thiol/disulphide homeostasis in children with febrile seizure.

Seizure 2018 Jul 31;59:34-37. Epub 2018 Jan 31.

Deparment of Biochemistry, Ankara Yıldırım Beyazıt University Atatürk Training and Research Hospital, Ankara, Turkey. Electronic address:

Purpose: Febrile seizure (FS) is the most common type of seizure in children and its etiopathogenesis is still not fully understood. We aimed to investigate the thiol/disulphide balance in children who had experienced FS in our study.

Methods: We included 40 FS and 40 control group subjects in the study. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.01.012DOI Listing
July 2018
5 Reads
2.060 Impact Factor

Interleukin-4 and tumor necrosis factor-alpha levels in children with febrile seizures.

Seizure 2018 May 6;58:156-162. Epub 2018 Apr 6.

Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea; International Healthcare Research Institute, Konkuk University, Seoul, Korea. Electronic address:

Purpose: The pathophysiology of febrile seizures remains unclear. Cytokines have been suggested to play a role in the pathogenesis of febrile seizures. We compared TNF-α and IL-4 levels in patients with febrile seizure (FS) with those in controls and identified the relationship between cytokines and various other factors. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.04.004DOI Listing
May 2018
3 Reads

Cytokine levels in febrile seizure patients: A systematic review and meta-analysis.

Seizure 2018 Jul 27;59:5-10. Epub 2018 Apr 27.

Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: Febrile seizures (FSs) are the most common form of childhood seizures. During infection, both pro-inflammatory and anti-inflammatory cytokines are produced. Complex interactions among immune-inflammatory process, cytokine activation, and genetic factors are involved in the pathogenesis of FSs. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.04.023DOI Listing

Serum Procalcitonin Levels in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion.

Dis Markers 2018 14;2018:2380179. Epub 2018 Mar 14.

Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF-, and IFN-) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group). Read More

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http://dx.doi.org/10.1155/2018/2380179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872605PMC
September 2018
3 Reads

Complex Febrile Seizures, Lumbar Puncture, and Central Nervous System Infections: A National Perspective.

Acad Emerg Med 2018 Apr 27. Epub 2018 Apr 27.

Department of Emergency Medicine and Cardiovascular Research Institute, Integrated Biosciences Center, Wayne State University School of Medicine, Detroit, MI.

Objectives: The objective was to determine the national lumbar puncture (LP) practice patterns relative to the incidence of central nervous system (CNS) infections among children presenting to the emergency department (ED) with complex febrile seizures (CFS).

Methods: This was a retrospective study of ED visits for CFS from 2007 to 2014 in patients aged 0 to 5 years using a national sample. Primary outcomes include the frequency of LP, incidence of CNS infections, and ED disposition. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/acem.13441
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http://dx.doi.org/10.1111/acem.13441DOI Listing
April 2018
34 Reads

Genetic (idiopathic) epilepsy with photosensitive seizures includes features of both focal and generalized seizures.

Sci Rep 2018 Apr 19;8(1):6254. Epub 2018 Apr 19.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Clinically, some patients having genetic (idiopathic) epilepsy with photosensitive seizures were difficult to be diagnosed. We aimed to discuss whether the genetic (idiopathic) epilepsy with photosensitive seizures is a focal entity, a generalized entity or a continuum. Twenty-two patients with idiopathic epilepsies and photoconvulsive response (PCR) were retrospectively recruited. Read More

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http://dx.doi.org/10.1038/s41598-018-24644-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908879PMC
April 2018
5 Reads

De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy.

Brain 2018 Jun;141(6):1703-1718

Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy.

V-type proton (H+) ATPase (v-ATPase) is a multi-subunit proton pump that regulates pH homeostasis in all eukaryotic cells; in neurons, v-ATPase plays additional and unique roles in synapse function. Through whole exome sequencing, we identified de novo heterozygous mutations (p.Pro27Arg, p. Read More

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http://dx.doi.org/10.1093/brain/awy092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972584PMC
June 2018
4 Reads

Prevalence, Incidence, and Recurrence of Febrile Seizures in Korean Children Based on National Registry Data.

J Clin Neurol 2018 Jan;14(1):43-47

Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.

Background And Purpose: Febrile seizures (FS) are the most common type of seizure during childhood, reportedly occurring in 2-5% of children aged 6 months to 5 years. However, there are no national data on the prevalence of FS in Korea. This study determined the prevalence, incidence, and recurrence rates of FS in Korean children using national registry data. Read More

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http://dx.doi.org/10.3988/jcn.2018.14.1.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765255PMC
January 2018
3 Reads

Spinal Fluid Cytokine Levels and Single-Photon Emission Computed Tomography Findings in Complex Febrile Seizures.

J Child Neurol 2018 May 4;33(6):417-421. Epub 2018 Apr 4.

1 Department of Pediatrics, Tokyo Medical University, Tokyo, Japan.

In this study, the authors assessed cerebrospinal fluid cytokine levels and single-photon emission computed tomography (SPECT) findings in complex febrile seizures. This study included 23 Japanese patients with complex febrile seizures. Twenty patients underwent SPECT and 12 underwent analysis of cerebrospinal fluid cytokine levels (interleukin [IL]-6, interleukin-10, interleukin-17, interleukin-1β, tumor necrosis factor-α, and interferon-γ); 9 patients underwent both studies. Read More

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http://dx.doi.org/10.1177/0883073818760890DOI Listing
May 2018
15 Reads