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Cureus 2020 Jun 4;12(6):e8435. Epub 2020 Jun 4.

Pediatric Endocrinology, Nemours Children's Hospital, Orlando, USA.

Severe hypercalcemia in diabetic ketoacidosis (DKA) among children is rare and can be life-threatening. Its exact etiology is not clear and several mechanisms related to dehydration and metabolic acidosis have been proposed. Rigorous hydration with the correct fluid choice usually corrects the hypercalcemia in those without other underlying causes of hypercalcemia such as hyperparathyroidism. Read More

Diabetes Care 2020 Jul 2. Epub 2020 Jul 2.

The Lundquist Institute for Biomedical Innovation, Torrance, CA.

Objective: This study aims to describe differences in health care utilization between homeless and nonhomeless minors with diabetes.

Research Design And Methods: Data from the Healthcare Cost and Utilization Project's Statewide Inpatient Database from New York for years 2009-2014 were examined to identify pediatric patients <18 years old with diabetes. Outcomes of interest included hospitalization rate, in-hospital mortality, admission through the emergency department (ED), diabetic ketoacidosis (DKA), hospitalization cost, and length of stay (LOS). Read More

Acta Diabetol 2020 Jun 27. Epub 2020 Jun 27.

Department of Public Health and Pediatrics, University of Study of Torino, Piazza Polonia 94, 10126, Turin, Italy.

Aims: The incidence of type 1 diabetes has increased over the last decades. The pathological pathway is not yet clear, even if genetic and environmental risk factors are known. An early diagnosis can avoid ketoacidosis and its complications. Read More

Diagnosis (Berl) 2020 Jun 25. Epub 2020 Jun 25.

Division of General Pediatrics, Boston Children's Hospital, Boston, MA, USA.

Objectives Using case review to determine whether a patient experienced a delayed diagnosis is challenging. Measurement would be more accurate if case reviewers had access to multi-expert consensus on grading the likelihood of delayed diagnosis. Our objective was to use expert consensus to create a guide for objectively grading the likelihood of delayed diagnosis of appendicitis, new-onset diabetic ketoacidosis (DKA), and sepsis. Read More

Medicine (Baltimore) 2020 Jun;99(25):e20553

Clinical Pharmacology & Toxicology, University Hospital / Inselspital Bern, Bern, Switzerland.

There is a paucity of information on real world management of African adult patients with type 1 diabetes mellitus (T1DM). We aimed to describe a cohort of African adults with T1DM.The International Diabetes Management Practices Study is an observational survey conducted from 2005 to 2017. Read More

Pediatr Emerg Care 2020 Jun 11. Epub 2020 Jun 11.

From the Department of Pediatrics, McMaster Children's Hospital.

Objectives: This study aims to better understand factors that impact management of patients with diabetic ketoacidosis (DKA) in the pediatric emergency department (ED) by novel application of the threat-and-error model, commonly used in the aviation industry.

Methods: This study was a retrospective chart review of all patients diagnosed with DKA and managed in our pediatric ED during a 1-year period. A "flight plan" was created for each patient's ED visit, from triage to final disposition. Read More

Nat Metab 2020 Feb 17;2(2):142-152. Epub 2020 Feb 17.

Laboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", Consiglio Nazionale delle Ricerche, Naples 80131, Italy.

An unresolved issue in autoimmunity is the lack of surrogate biomarkers of immunological self-tolerance for disease monitoring. Here, we show that peripheral frequency of a regulatory T cell population, characterized by the co-expression of CD3 and CD56 molecules (T), is reduced in subjects with new-onset type 1 diabetes (T1D). In three independent T1D cohorts, we find that low frequency of circulating T cells is associated with reduced β-cell function and with the presence of diabetic ketoacidosis. Read More

Acta Diabetol 2020 Jun 2. Epub 2020 Jun 2.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology (ZIBMT), Ulm University, Albert-Einstein-Allee 41, 89081, Ulm, Germany.

Aims: To compare diabetes patients with hyperglycaemic hyperosmolar state (HHS), diabetic ketoacidosis (DKA), and patients without decompensation (ND).

Methods: In total, 500,973 patients with type 1 or type 2 diabetes of all ages registered in the diabetes patient follow-up (DPV) were included. Analysis was stratified by age (≤ / > 20 years) and by manifestation/follow-up. Read More

Pediatr Diabetes 2020 May 29. Epub 2020 May 29.

Department of Medicine, Valley Children's Hospital, Madera, California.

Objective: To determine the causes, predictors, and trends of 30-day readmissions following hospitalizations for pediatric diabetic ketoacidosis (DKA) in the United States (US) from 2010 to 2014.

Research Design And Methods: We used International Classification of Diseases, ninth revision, Clinical Modification codes to identify children with DKA aged 2 to 18 years from the National Readmission Database in the US. Patients who had readmission within 30 days after an index admission for DKA were included in the study. Read More

Acta Diabetol 2020 May 28. Epub 2020 May 28.

Department of Pediatrics, Santa Maria delle Croci Hospital, Ravenna, Italy.

J Pediatr Endocrinol Metab 2020 May 24;33(6):751-759. Epub 2020 May 24.

German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.

Background To investigate longitudinal trends of admissions with diabetic ketoacidosis (DKA) in new-onset type 1 diabetes (T1D) and subsequent duration of hospitalization in association with structural health care properties, such as size of treatment facility, population density and linear distance between home and treatment centers. Methods Data from 24,321 German and Austrian pediatric patients with newly-diagnosed T1D between 2008 and 2017 within the DPV registry were analyzed. Results Onset-DKA rates fluctuated at around 19% and slightly increased over the observation period (p<0. Read More

J Pediatr 2020 Jun;221:165-173.e2

Divisions of Diabetes and Endocrinology, British Columbia Children's Hospital and Department of Pediatrics, University of British Columbia, Vancouver, Canada. Electronic address:

Objectives: To estimate the 11-year incidence trend of diabetic ketoacidosis (DKA) at and after the diagnosis of type 1 diabetes.

Study Design: A retrospective cohort study using a population-based administrative cohort diagnosed with type 1 diabetes at <20 years of age from 2002 to 2012 in British Columbia, Canada. DKA at (1 episode per individual) and DKA after (multiple episodes per individual) the diagnosis of diabetes were defined as DKA occurring ≤14 days or >14 days, respectively, from diagnosis, identified using International Classification of Diseases,9th and 10theditions codes. Read More

Pediatr Qual Saf 2020 Mar-Apr;5(2):e260. Epub 2020 Feb 15.

Children's Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, Philadelphia, Pa.

Introduction: In many centers, children with diabetic ketoacidosis (DKA) receive care either in an endocrinology ward or a pediatric intensive care unit (PICU). We conducted a quality improvement (QI) initiative to reduce potentially avoidable PICU admissions of children with DKA without increasing endocrinology ward-to-PICU transfers.

Methods: A survey of providers demonstrated opportunities to increase awareness of institutional criteria for PICU admissions of children with DKA. Read More

BMC Pediatr 2020 May 18;20(1):228. Epub 2020 May 18.

Department of Paediatrics, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, India.

Background: Although hyperglycemia and pancreatitis are known side effects of L-asparaginase, both contributing to the development of diabetic ketoacidosis (DKA) is unfamiliar in literature.

Case Presentation: We report a case of an adolescent girl, recently diagnosed with ALL, who presented with pain in abdomen and breathing difficulty following chemotherapy with L-asparaginase. On subsequent evaluation, she was found to have high anion gap metabolic acidosis, hyperglycemia and ketonuria. Read More

Pediatr Diabetes 2020 May 16. Epub 2020 May 16.

Department of Medical and Surgical Sciences of the Mother, Children and Adults, Pediatric Unit - University of Modena and Reggio Emilia, Modena, Italy.

Objective: To determine if the diabetes-specific health-related quality of life (D-HRQOL) of young people with type 1 diabetes (T1D) and their parents is influenced by migrant status.

Subjects And Methods: One hundred and twenty-five patients (12.4 ± 3. Read More

Nat Rev Dis Primers 2020 May 14;6(1):40. Epub 2020 May 14.

Diabetes & Endocrinology, Emory University School of Medicine, Atlanta, GA, USA.

Diabetic ketoacidosis (DKA) is the most common acute hyperglycaemic emergency in people with diabetes mellitus. A diagnosis of DKA is confirmed when all of the three criteria are present - 'D', either elevated blood glucose levels or a family history of diabetes mellitus; 'K', the presence of high urinary or blood ketoacids; and 'A', a high anion gap metabolic acidosis. Early diagnosis and management are paramount to improve patient outcomes. Read More

J Pediatr 2020 May 6. Epub 2020 May 6.

Department of Pediatrics, University of California Davis Health, University of California Davis, School of Medicine. Electronic address:

Objectives: To characterize hemodynamic alterations occurring during diabetic ketoacidosis (DKA) in a large cohort of children and to identify clinical and biochemical factors associated with hypertension.

Study Design: This was a planned secondary analysis of data from the Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in DKA (FLUID) Study, a randomized clinical trial of fluid resuscitation protocols for children in DKA. Hemodynamic data (heart rate, blood pressure) from children with DKA were assessed in comparison with normal values for age and sex. Read More

Diabetes Technol Ther 2020 Jun 5;22(6):449-453. Epub 2020 May 5.

Professor of Medicine and Pediatrics, Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, Colorado, USA.

The Stay at Home order in Colorado and The Stay Safe at Home order in California during COVID-19 pandemic have forced a majority of the endocrinologists/diabetologists to adapt to providing diabetes care remotely through telehealth. This may provide increased access to diabetes health care in certain settings. However, health care disparities continue to challenge availability of diabetes technologies for underprivileged communities. Read More

Diabetologia 2020 Aug 8;63(8):1530-1541. Epub 2020 May 8.

Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Aims/hypothesis: The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 diabetes in 13 countries over three continents.

Methods: An international retrospective study on DKA at diagnosis of diabetes was conducted. Data on age, sex, date of diabetes diagnosis, ethnic minority status and presence of DKA at diabetes onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA and the UK (Wales). Read More

J Paediatr Child Health 2020 May 4. Epub 2020 May 4.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Psychosom Med 2020 05;82(4):359-365

From the Medical Psychological Center, The Second Xiangya Hospital (J. He, J. Zhu, Du, Sh. Li, Si. Li, X. Zhu), Central South University, Changsha, China; Department of Psychology (J. He), The First Normal University, Changsha, China; Hunan Key Laboratory of Children's Psychological Development and Brain Cognitive Science (J. He), Changsha, China; Medical Psychological Institute of Central South University (J. Zhu, Du, Sh. Li, Si. Li, X. Zhu), Changsha, China; National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital (X. Zhu), Changsha, China; Department of Metabolism and Endocrinology, The Second Xiangya Hospital (Xie, X. Li, Zhou), Central South University, Changsha, China; National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital (Xie, X. Li, Zhou), Changsha, China; and Children's Healthcare Institution, Hu Nan Children's Hospital (W. He), The University of South China Academy of Pediatrics, Changsha, China.

Objective: Diabetic ketoacidosis (DKA) in patients with type 1 diabetes mellitus (T1DM) is known to affect memory function, but little is known about its impact on executive function. This study aimed to determine whether a history of DKA was associated with changes in executive function in children with T1DM.

Methods: The sample consisted of 99 patients with T1DM with histories of DKA, 82 patients with T1DM without DKA, and 100 healthy controls aged 7 to 18 years. Read More

J Pediatr Intensive Care 2020 Jun 8;9(2):113-118. Epub 2020 Jan 8.

Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States.

A retrospective study was done to determine the effect of potassium (K ) infusions on serum levels in children admitted to the pediatric intensive care unit (PICU) with diabetic ketoacidosis (DKA). Eighty-two percent of 92 cases studied received 40 mEq/L K infusion over the treatment period of median 13.0 (interquartile range [IQR]: 7-18) hours. Read More

J Diabetes Complications 2020 Apr 13:107584. Epub 2020 Apr 13.

Section on Endocrinology & Genetics (SEGEN), National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.

Mitochondrial disorders refer to the complex group of conditions affecting energy metabolism. A number of mitochondrial disorders can lead to the development of diabetes mellitus, and mitochondrial diabetes is thought to account for up to 3% of all diabetes mellitus cases. Depending on the degree of preservation of beta cell secretory capacity and peripheral muscle insulin sensitivity, the phenotype of mitochondrial diabetes may resemble that of type 1 or type 2 diabetes. Read More

Orphanet J Rare Dis 2020 Apr 22;15(1):100. Epub 2020 Apr 22.

Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

Background: Wolcott-Rallison syndrome (WRS) is characterized by permanent early-onset diabetes, skeletal dysplasia and several additional features, e.g. recurrent liver failure. Read More

Endocrinol Diabetes Metab Case Rep 2020 Mar 25;2020. Epub 2020 Mar 25.

Brehm Center for Diabetes Research and Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan, USA.

Summary: A patient with atypical partial lipodystrophy who had a transient initial response to metreleptin experienced acute worsening of her metabolic state when neutralizing antibodies against metreleptin appeared. Because her metabolic status continued to deteriorate, a therapeutic trial with melanocortin-4 receptor agonist setmelanotide, that is believed to function downstream from leptin receptor in the leptin signaling system, was undertaken in an effort to improve her metabolic status for the first time in a patient with lipodystrophy. To achieve this, a compassionate use (investigational new drug application; IND) was initiated (NCT03262610). Read More

Arch Argent Pediatr 2020 Apr;118(2):135-138

Hospital Niño de Saltillo. Saltillo, Coahuila, México.

Acute kidney injury is a cause of morbidity in children with diabetes in developing countries, especially in patients with diabetic ketoacidosis. The objective of this study was to identify the risk factors for acute kidney injury in patients with diabetic ketoacidosis. This was a retrospective cohort study. Read More

Pediatr Diabetes 2020 Aug 31;21(5):791-799. Epub 2020 Mar 31.

Department of Pediatrics, Fundación Universitaria de Ciencias de la Salud, Hospital Universitario Infantil de San José, Bogotá, Colombia.

Objective: To compare the duration (hours until  ≥ 15 mmol/L) of diabetic ketoacidosis (DKA) episodes that are the first manifestation of new type 1 diabetes (NT1D) and those that are a complication in patients with previously diagnosed type 1 diabetes (PT1D).

Methods: A multicenter retrospective cohort study was designed. The duration of DKA was measured from the start of the treatment. Read More

J Med Virol 2020 Feb 28. Epub 2020 Feb 28.

Department of Pediatric Endocrinology and Metabolism, Istanbul Medipol University, Istanbul, Turkey.

We aimed to identify the determinants of partial remission in patients with type 1 diabetes mellitus (DM), and whether there is an influence of vaccination against measles on partial remission. This was a retrospective study consisting of consecutive patients diagnosed with type 1 DM followed-up from 1 September 2010, through 30 November 2011. The study included children vaccinated within 3 months after diagnosis, and children unvaccinated during the first 12 months of the disease. Read More

Comb Chem High Throughput Screen 2020 ;23(3):185-190

Department of Pediatrics, University of Hacettepe, Pediatric Intensive Care Unit, İhsan Doğramacı Children Hospital, Ankara, Turkey.

Aims And Objective: This study aimed to investigate the value of Thiol/Disulfide homeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus.

Materials And Methods: This study featured children who were diagnosed with diabetic ketoacidosis and who were consecutively admitted to pediatric intensive care within one year of their diagnosis. Thiol/disulfide homeostasis was evaluated in 45 pediatric patients suffering from DKA, as well as 45 healthy controls of parallel gender and age. Read More

Pediatrics 2020 03 13;145(3). Epub 2020 Feb 13.

Departments of Emergency Medicine.

Background And Objectives: Children with established type 1 diabetes (T1D) who present to the emergency department (ED) with mild diabetic ketoacidosis (DKA) are often hospitalized, although outpatient management may be appropriate. Our aim was to reduce hospitalization rates for children with established T1D presenting to our ED with mild DKA who were considered low risk for progression of illness.

Methods: We conducted a quality improvement initiative between January 1, 2012, and December 31, 2018 among children and young adults ≤21 years of age with established T1D presenting to our tertiary care ED with low-risk DKA. Read More

Endocr Pract 2020 May 11;26(5):508-513. Epub 2020 Feb 11.

Every year, 500,000 youths in the U.S. with chronic disease turn 18 years of age and eventually require transfer to adult subspecialty care. Read More

Pediatr Emerg Care 2020 Feb 1. Epub 2020 Feb 1.

From the Divisions of Endocrinology.

Objective: Diabetic ketoacidosis (DKA) is a common emergency department presentation of both new-onset and established diabetes mellitus (DM). β-Hydroxybutyrate (BOHB) provides a direct measure of the pathophysiologic derangement in DKA as compared with the nonspecific measurements of blood pH and bicarbonate. Our objective was to characterize the relationship between BOHB and DKA. Read More

Nephrol Dial Transplant 2020 01;35(Suppl 1):i24-i32

Section of Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

Diabetic kidney disease (DKD) is a common complication of type 1 diabetes (T1D) and a major risk factor for premature death from cardiovascular disease (CVD). Current treatments, such as control of hyperglycaemia and hypertension, are beneficial, but only partially protect against DKD. Finding new, safe and effective therapies to halt nephropathy progression has proven to be challenging. Read More

JAMA 2020 Jan;323(4):339-351

Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.

Importance: Public health screening for type 1 diabetes in its presymptomatic stages may reduce disease severity and burden on a population level.

Objective: To determine the prevalence of presymptomatic type 1 diabetes in children participating in a public health screening program for islet autoantibodies and the risk for progression to clinical diabetes.

Design, Setting, And Participants: Screening for islet autoantibodies was offered to children aged 1. Read More

Diabetes Care 2020 Mar 22;43(3):e40-e42. Epub 2020 Jan 22.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Pediatr Diabetes 2020 Jan 14. Epub 2020 Jan 14.

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.

Background: There is significant global variation in the prevalence of diabetic ketoacidosis (DKA) at diagnosis among youth with type 1 diabetes (T1D). However, data for youth with type 2 diabetes (T2D) are limited, even in developed countries. We compared the prevalence of DKA at diagnosis among individuals with T1D and T2D from the SEARCH for Diabetes in Youth (SEARCH) and the Registry of Youth Onset Diabetes in India (YDR) registries. Read More

World J Diabetes 2020 Jan;11(1):13-25

Department of Pathology, Johns Hopkins Medical Center, Baltimore, MD 21205, United States.

Type 1 diabetes (T1D) is an autoimmune disease that usually strikes early in life, but can affect individuals at almost any age. It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas. Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5% annually worldwide. Read More

J Pediatr Endocrinol Metab 2020 Feb;33(2):319-322

Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland.

Background Cerebral edema (CE) is one of the most serious complications of diabetic ketoacidosis (DKA) and can result in central nervous system (CNS) disorders and even lead to death of the patient. Case presentation We present the case of a 11-year-old boy with severe DKA in the course of newly diagnosed type 1 diabetes (T1D). The delay in the diagnosis of DKA and some therapeutic problems contributed to the development of CE and direct life-threatening conditions. Read More

Ann Pediatr Endocrinol Metab 2019 Dec 31;24(4):257-261. Epub 2019 Dec 31.

Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea.

In recent years, reports of diabetes mellitus (DM) cases that do not fit the traditional classification system have increased in prevalence. While insulin deficiency appears as type 1 DM (T1DM), the new type also has the clinical features of type 2 DM (T2DM); as such, this new type of DM is called ketosis-prone diabetes (KPD) and is correlated with findings of severe hyperglycemia and ketoacidosis. To provide a clear, clinical classification of DM, new classification systems are being studied. Read More

Crit Care 2020 01 2;24(1). Epub 2020 Jan 2.

Division of Pediatric Allergy & Immunology, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

Background: Acute kidney injury (AKI) is an important complication encountered during the course of diabetic ketoacidosis (DKA). Plasma-Lyte with lower chloride concentration than saline has been shown to be associated with reduced incidence of AKI in adults with septic shock. No study has compared this in DKA. Read More

Int J Pediatr Adolesc Med 2019 Dec 28;6(4):125-130. Epub 2019 May 28.

Department of Pediatrics, College of Medicine, Qassim University, Qassim, Saudi Arabia.

Diabetes in children has increased globally, and the World Health Organization ranks Saudi Arabia 7th in prevalence and 5th in incidence of type 1 diabetes (T1D). Type 2 diabetes (T2D) in children and adolescents has been identified in Saudi Arabia but its prevalence is still unknown. Despite advances in diabetes management including new insulins, insulin delivery systems, glucose monitoring and easy access to media for disease awareness, diabetes in children continues to be challenging in many aspects. Read More

Horm Res Paediatr 2019 20;92(3):179-185. Epub 2019 Dec 20.

Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Introduction: Insulin degludec (IDeg) is the longest-acting basal insulin available. Whether IDeg compared to shorter-acting basal insulins like insulin glargine U100 (IGlarU100) reduces the rate of diabetic ketoacidosis (DKA) in adolescents with type 1 diabetes is unknown.

Objective: We hypothesized that adolescents with type 1 diabetes would have lower DKA rates and mean hemoglobin A1c (HbA1c) when using IDeg as compared to IGlarU100. Read More

Diabetes Metab Syndr Obes 2019 12;12:2355-2361. Epub 2019 Nov 12.

Division of Pediatric Emergency and Intensive Care, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Diabetic ketoacidosis (DKA) is a preventable life-threatening complication of type 1 diabetes. Fluids form a crucial component of DKA therapy, goals being the restoration of intravascular, interstitial and intracellular compartments. Hydration reduces hyperglycemia by decreased counter-regulatory hormones, enhanced renal glucose clearance and augmented insulin sensitivity. Read More

J Pediatr Endocrinol Metab 2020 Feb;33(2):179-184

Eastern Virginia Medical School/Children's Hospital of the King's Daughters, Department of Pediatrics, Division of Pediatric Endocrinology, Norfolk, VA, USA.

Background Insulin pumps are a frequently used technology among youth with type 1 diabetes. Air bubbles within insulin pump tubing are common, preventing insulin delivery and increasing the risk of large glycemic excursions and diabetic ketoacidosis (DKA). We sought to determine the prevalence of air bubbles in insulin pump tubing and identify factors associated with clinically significant air bubbles. Read More

Biomed Res Int 2019 24;2019:6128410. Epub 2019 Oct 24.

Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Medical University of Białystok, Białystok, Poland.

Introduction: The increasing knowledge of adropin, afamin, and neudesin and the regulation of glucose metabolism and insulin resistance allows for the assessment of the differences in their concentrations between the groups with varied duration of diabetes mellitus (DM).

Aim Of The Study: Assessment of serum levels of adropin, afamin, and neudesin in children with type 1 diabetes, with respect to the disease duration.

Materials And Methods: The study consisted of 138 patients aged 5-18 years (M 40. Read More

Clin Chem 2019 12;65(12):1610-1612

Metabolic Unit, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Transl Behav Med 2019 Nov 25. Epub 2019 Nov 25.

Children's National Health System, Washington, DC, USA.

Psychosocial guidelines recommend routine screening of depressive symptoms in adolescents and young adults (AYA) with diabetes. Best practices for screening in routine care and patient characteristics associated with depressive symptoms require further investigation. The purpose of this study was to examine psychometric properties of the Patient Health Questionnaire (PHQ-2 and PHQ-9); document rates of depressive symptoms and related clinical actions; and evaluate associations with patient characteristics. Read More

Minerva Pediatr 2019 Nov 11. Epub 2019 Nov 11.

Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

Background: Hepatitis B virus (HBV) vaccine reduced the incidence of Hepatitis B worldwide. Genetic variability , by the presence of specific haplotypes of HLA system (HLA-DR3, HLA-DR4) , influences the response to the vaccination. Subjects affected by T1D, contrary to non-diabetics, have a high prevalence of Hepatitis B. Read More

J Clin Res Pediatr Endocrinol 2020 06 14;12(2):189-196. Epub 2019 Nov 14.

Ege University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Emergency, İzmir, Turkey

Objective: Despite the guidelines, significant variations can be encountered in initial therapy for pediatric diabetic ketoacidosis (DKA) in the prehospital setting. These variations occur mostly in fluid administration, insulin dosing, route of administration, and other aspects of the initial resuscitation and stabilization. The aim was to identify the effect of transport care on outcomes in children with DKA admitted to the emergency department (ED). Read More

Indian J Pediatr 2020 01 12;87(1):89-90. Epub 2019 Nov 12.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.