1,427 results match your criteria Pediatrics Dehydration


Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration.

Sci Rep 2019 Feb 12;9(1):1873. Epub 2019 Feb 12.

Institute for Integrative Toxicology at Michigan State University, East Lansing, 48824, MI, USA.

The lateral hypothalamic area (LHA) is essential for ingestive behavior but it remains unclear how LHA neurons coordinate feeding vs. drinking. Most LHA populations promote food and water consumption but LHA neurotensin (Nts) neurons preferentially induce water intake while suppressing feeding. Read More

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http://www.nature.com/articles/s41598-018-38143-9
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http://dx.doi.org/10.1038/s41598-018-38143-9DOI Listing
February 2019
5 Reads

Vomiting and Dehydration in a 2-Year-Old.

Pediatrics 2019 Feb 12. Epub 2019 Feb 12.

Divisions of Emergency Medicine and.

A 2-year-old girl with a past medical history of cutaneous mastocytosis and eczema presented with 1 day of yellow-green, nonbloody vomiting, bradycardia, and listlessness. She was evaluated by her pediatrician and sent to the emergency department because of concern for dehydration. In the emergency department, she improved with fluid rehydration but still had decreased energy and bradycardia. Read More

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http://dx.doi.org/10.1542/peds.2018-0504DOI Listing
February 2019

Medical Assessment and Triage of Pediatric Patients with Anorexia Nervosa in Primary Care.

J Dev Behav Pediatr 2019 Feb/Mar;40(2):92-98

Division of Internal Medicine and Pediatrics, University of California, Los Angeles, CA.

Objective: To examine the medical assessment and triage of pediatric patients with anorexia nervosa (AN) initially seen in primary care.

Methods: A retrospective cohort study was conducted for all pediatric patients with AN who had eating/weight concerns and initially identified symptoms in primary care in a single health care system between January 1, 2010, and December 31, 2016. Information on presenting concern, medical assessment/laboratory tests, clinical diagnoses, treatment recommendations, and referrals were abstracted from the medical record. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000629DOI Listing
February 2019
1 Read

Celiac crisis, a rare occurrence in adult celiac disease: A systematic review.

World J Clin Cases 2019 Feb;7(3):311-319

Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.

Background: Celiac crisis (CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease (CD). Several cases have been documented in the literature, mostly in children.

Aim: To perform a review of CC cases reported in adult CD patients. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i3.311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369385PMC
February 2019
1 Read

Congenital adrenal hyperplasia with salt-wasting crisis and arrhythmia: a case study.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Paediatrics, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.

We report a case of a 10-day-old male infant who presented to the emergency department with severe electrolyte imbalance and life-threatening arrhythmia. The parents reported a 3-day history of poor feeding and lethargy. On examination, he was bradycardic (heart rate of 65 beats/min) with signs of dehydration. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22756
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http://dx.doi.org/10.1136/bcr-2018-227565DOI Listing
January 2019
20 Reads

Does the addition of dextrose to IV crystalloid therapy provide clinical benefit in acute dehydration? A systematic review and meta-analysis.

CJEM 2019 Jan 30:1-8. Epub 2019 Jan 30.

†Department of Emergency Medicine,Indiana University School of Medicine,Indianapolis, IN.

CLINICIAN'S CAPSULEWhat is known about the topic?Intravenous dextrose halts endogenous ketone production and is commonly recommended in dehydrated patients unable to tolerate oral intake.What did this study ask?Is there evidence that the addition of dextrose to intravenous fluids provides a clinically meaningful benefit in dehydrated patients?What did this study find?Intravenous dextrose has not been shown to provide any important benefit to patients in this setting, but further research is needed.Why does this study matter to clinicians?In dehydrated patients, clinicians should not feel obligated towards dextrose containing solutions, which may be more expensive and less readily available. Read More

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http://dx.doi.org/10.1017/cem.2018.500DOI Listing
January 2019
1 Read

Congenital glucose-galactose malabsorption: A case report with a novel mutation.

Clin Case Rep 2019 Jan 11;7(1):51-53. Epub 2018 Nov 11.

Department of Pediatrics, School of Medicine The university of Jordan Amman Jordan.

A three-day-old newborn girl presented with decreased feeding and dehydration. She was sick and in shock. She had renal impairment and hypernatremia. Read More

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http://doi.wiley.com/10.1002/ccr3.1913
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http://dx.doi.org/10.1002/ccr3.1913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333054PMC
January 2019
14 Reads

Body hydration assessment using bioelectrical impedance vector analysis in neurologically impaired children.

Eur J Clin Nutr 2019 Jan 16. Epub 2019 Jan 16.

Paediatric Surgery Department, Children's Hospital "G. Di Cristina", ARNAS Civico-di Cristina-Benfratelli", Palermo, Italy.

Dehydration is common and frequently under-diagnosed in chronic malnourished children, leading to life-threatening conditions. In this pilot study we applied bioimpedance vector analysis (BIVA) to determine hydration status in 52 neurologically impaired (NI) paediatric patients (14.08 ± 5. Read More

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http://dx.doi.org/10.1038/s41430-018-0384-7DOI Listing
January 2019
3 Reads

Infant Botulism With Asymmetric Cranial Nerve Palsies.

Pediatr Neurol 2018 Nov 30. Epub 2018 Nov 30.

Baylor College of Medicine, Department of Pediatrics, Section of Neurology and Developmental Neuroscience, Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.016DOI Listing
November 2018
2 Reads

Malignant gastrointestinal neuroectodermal tumor (clear cell sarcoma-like tumor of the gastrointestinal tract) of the small intestine in a 12-year-old boy.

Dev Period Med 2018 ;22(4):358-363

Department of General Pathomorphology, Medical University of Białystok, Białystok, Poland.

The aim of this paper is a clinical and anatomopathological demonstration of a malignant lesion, a gastrointestinal neuroectodermal tumor (GNET), as an exceedingly rare cause of ileus in the pediatric population. Specifically, we present the case of a 12-year-old boy who showed dramatic weight loss, hypochromic anemia, fever, dehydration, exaggerated granulation of the terminal ileum, and mechanical ileus due to the obstruction by an intramural tumor of the small intestine. A 50cm-long part of the small intestine with pathological stricture was surgically removed, sampled and routinely fixed and stained with hematoxylin and eosin. Read More

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January 2018
1 Read

Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients.

Kidney Res Clin Pract 2018 Dec 31;37(4):347-355. Epub 2018 Dec 31.

Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.

Background: Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) is a common complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression of NS. However, the incidence and risk factors of childhood-onset NS in Korea are unclear. Read More

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http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krc
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http://dx.doi.org/10.23876/j.krcp.18.0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312784PMC
December 2018
5 Reads

Collodion baby treated at a tertiary hospital in Tanzania: a case report.

J Med Case Rep 2018 Dec 31;12(1):385. Epub 2018 Dec 31.

Department of Paediatrics and Child health, School of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), 9 United Nations Road, Upanga West, P.O. Box 65001, Dar-es-salaam, Tanzania.

Background: The term "collodion baby" is used to describe a newborn covered with a translucent, parchment-like skin sheet. It is an extremely rare condition with an estimated incidence of 1 in 300,000 live births. Clinically, the baby will present with a collodion membrane with fissures, ectropium, eclabium, and hypoplastic digits. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1912-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311898PMC
December 2018
8 Reads

Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.

Minerva Pediatr 2019 Feb;71(1):82-99

Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.

Unlike fever, which is often over-treated especially in children, pain is underestimated and under-treated in pediatric age. The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years. Paracetamol and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen are the most used at this purpose. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05453-1DOI Listing
February 2019
2 Reads

Milk feed osmolality and adverse events in newborn infants and animals: a systematic review.

Arch Dis Child Fetal Neonatal Ed 2018 Dec 6. Epub 2018 Dec 6.

Danone Nutricia Research, Utrecht, The Netherlands.

Background: High feed osmolality (or osmolarity) is often suggested to be linked with adverse gastrointestinal events in preterm infants.

Aim: To systematically review the literature on milk feed osmolality and adverse gastrointestinal events in newborn and low birthweight infants and animals.

Methods: MEDLINE, Embase, CAB Abstracts, Current Contents, BIOSIS Previews and SciSearch were searched from inception to May 2018 to identify potentially relevant studies. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315946DOI Listing
December 2018
2 Reads
3.120 Impact Factor

Introduction of an Oral Fluid Challenge Protocol in the Management of Children with Acute Gastroenteritis: A Regional Hospital Experience.

Ir Med J 2018 06 7;111(6):775. Epub 2018 Jun 7.

Academic Department of Paediatrics, National University of Ireland, Galway, Ireland

Oral rehydration therapy (ORT) remains the ideal first line therapy for acute gastroenteritis (AGE). Our aim was to assess the impact of introducing an Oral Fluid Challenge (OFC) protocol on outcomes such as intravenous fluid use and documentation in our institution. A single centre study with data collected retrospectively pre-implementation (April 2015) of the OFC protocol and post implementation (April 2016). Read More

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June 2018
4 Reads

Fanconi Syndrome.

Authors:
John W Foreman

Pediatr Clin North Am 2019 02;66(1):159-167

Department of Pediatrics, Duke University School of Medicine, Erwin Road, Durham, NC 27710, USA. Electronic address:

Fanconi syndrome, also known as the DeToni, Debré, Fanconi syndrome is a global dysfunction of the proximal tubule characterized by glucosuria, phosphaturia, generalized aminoaciduria, and type II renal tubular acidosis. Often there is hypokalemia, sodium wasting, and dehydration. In children, it typically is caused by inborn errors of metabolism, principally cystinosis. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.09.002DOI Listing
February 2019
1 Read

Paediatric deaths in a tertiary government hospital setting, Malawi.

Paediatr Int Child Health 2018 Nov 19:1-9. Epub 2018 Nov 19.

g Centre for Medical Education , Queen's University , Belfast , UK.

Background: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS.

Aims: To determine the causes of inpatient child death including microbiological aetiologies in Malawi. Read More

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https://www.tandfonline.com/doi/full/10.1080/20469047.2018.1
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http://dx.doi.org/10.1080/20469047.2018.1536873DOI Listing
November 2018
12 Reads

Needs Assessment for Simulation Training for Prehospital Providers in Botswana.

Prehosp Disaster Med 2018 Dec 13;33(6):621-626. Epub 2018 Nov 13.

5Emergency Medical Services,Botswana Ministry of Health and Wellness,Gaborone,Botswana.

Background: In June 2012, the Botswana Ministry of Health and Wellness (MOHW; Gaborone, Botswana) initiated a national Emergency Medical Services (EMS) system in response to significant morbidity and mortality associated with prehospital emergencies. The MOHW requested external expertise to train its developing workforce. Simulation-based training was planned to equip these health care providers with clinical knowledge, procedural skills, and communication techniques. Read More

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http://dx.doi.org/10.1017/S1049023X18001024DOI Listing
December 2018
13 Reads

Oral Ondansetron Administration to Nondehydrated Children With Diarrhea and Associated Vomiting in Emergency Departments in Pakistan: A Randomized Controlled Trial.

Ann Emerg Med 2018 Nov 1. Epub 2018 Nov 1.

Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.

Study Objective: We determine whether single-dose oral ondansetron administration to children with vomiting as a result of acute gastroenteritis without dehydration reduces administration of intravenous fluid rehydration.

Methods: In this 2-hospital, double-blind, placebo-controlled, emergency department-based, randomized trial conducted in Karachi Pakistan, we recruited children aged 0.5 to 5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960644183126
Publisher Site
http://dx.doi.org/10.1016/j.annemergmed.2018.09.011DOI Listing
November 2018
7 Reads

Magnitude and pattern of improvement in processes of care for hospitalised children with diarrhoea and dehydration in Kenyan hospitals participating in a clinical network.

Trop Med Int Health 2019 Jan 11;24(1):73-80. Epub 2018 Nov 11.

Kenya Medical Research Institute/Wellcome Trust Research Programme, Nairobi, Kenya.

Objective: WHO recommends optimisation of available interventions to reduce deaths of under-five children with diarrhoea and dehydration (DD). Clinical networks may help improve practice across many hospitals but experience with such networks is scarce. We describe magnitude and patterns of changes in processes of care for children with DD over the first 3 years of a clinical network. Read More

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http://doi.wiley.com/10.1111/tmi.13176
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http://dx.doi.org/10.1111/tmi.13176DOI Listing
January 2019
9 Reads

Pediatric Dehydration Assessment at Triage: Prospective Study on Refilling Time.

Pediatr Gastroenterol Hepatol Nutr 2018 Oct 10;21(4):278-288. Epub 2018 Oct 10.

Pediatric Department, Ospedale "F. Del Ponte", University of Insubria, Varese, Italy.

Purpose: Dehydration is a paediatric medical emergency but there is no single standard parameter to evaluate it at the emergency department. Our aim was to evaluate the reliability and validity of capillary refilling time as a triage parameter to assess dehydration in children.

Methods: This was a prospective pilot cohort study of children who presented to two paediatric emergency departments in Italy, with symptoms of dehydration. Read More

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http://dx.doi.org/10.5223/pghn.2018.21.4.278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182472PMC
October 2018
2 Reads

The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis.

Curr Opin Pharmacol 2018 Dec 16;43:152-165. Epub 2018 Oct 16.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA; The Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Cystic fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR dysfunction is characterized by abnormal mucociliary transport due to a dehydrated airway surface liquid (ASL) and hyperviscous mucus, among other pathologies of host defense. ASL depletion is caused by the absence of CFTR mediated chloride secretion along with continued activity of the epithelial sodium channel (ENaC) activity, which can also be affected by CFTR mediated anion conductance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14714892183004
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http://dx.doi.org/10.1016/j.coph.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294660PMC
December 2018
13 Reads

Bronchiolitis clinics and medical treatment.

Minerva Pediatr 2018 Dec 18;70(6):600-611. Epub 2018 Oct 18.

Department of Pediatrics, Sapienza University, Rome, Italy.

Bronchiolitis is the most common acute lower respiratory tract infection in infants and the first cause of hospitalization in this age group. Despite it has been studied for over 70 years, its management remains controversial and nowadays the treatment is only supportive. Pediatricians should be well acquainted with the clinical course of the disease. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05334-3DOI Listing
December 2018
11 Reads

Severe Acute Kidney Injury and Multiple Organ Failure in a 17-Day-Old Newborn: When Pathology Makes the Difference.

Can J Kidney Health Dis 2018 6;5:2054358118804834. Epub 2018 Oct 6.

Division of Nephrology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, QC, Canada.

Rationale: Acute tubulointerstitial nephritis (ATIN) in children is most commonly due to allergic drug reactions. In neonates, diagnosis of ATIN is clinically suspected and a kidney biopsy is not routinely performed.

Presenting Concern: A 17-day-old newborn presented with vomiting and dehydration, along with anuric acute kidney injury, severe electrolyte disturbances, hypocomplementemia, and thrombocytopenia. Read More

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http://dx.doi.org/10.1177/2054358118804834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174648PMC
October 2018
3 Reads

Chinese clinical practice guidelines for acute infectious diarrhea in children.

World J Pediatr 2018 Oct 29;14(5):429-436. Epub 2018 Sep 29.

Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China.

Background: The guidelines addressed the evidence-based indications for the management of children with acute infectious diarrhea in Chinese pediatric population.

Data Sources: The experts group of evidence development put forward clinical problems, collects evidence, forms preliminary recommendations, and then uses open-ended discussions to form recommendations. The literature review was done for developing this guideline in databases including PubMed, Cochrane, EMBASE, China Biomedical Database, and Chinese Journal Full-text Database up to June 2013. Read More

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http://dx.doi.org/10.1007/s12519-018-0190-2DOI Listing
October 2018
10 Reads

Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study.

Eur J Pediatr 2018 Dec 24;177(12):1837-1844. Epub 2018 Sep 24.

Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.

Diarrhea-associated hemolytic uremic syndrome is characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury secondary to enteric infection, typically Shiga toxin-producing Escherichia coli. Shiga toxin 2 is able to activate alternative complement pathways; therefore, the aim of the study was to analyze C3 as a predictor of clinical courses in patients with diarrhea-associated hemolytic uremic syndrome. We hypothesized that the patients with increased complement activation at admission suffered from a more severe course. Read More

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http://dx.doi.org/10.1007/s00431-018-3255-2DOI Listing
December 2018
8 Reads
1.983 Impact Factor

Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stressed humans.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 19;316(2):R145-R156. Epub 2018 Sep 19.

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas , Dallas, Texas.

Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses would be increased by passive heat stress, as well as exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult. In aim 1, subjects were exposed to passive heating or normothermic time control, each followed by progressive lower-body negative pressure (LBNP) to presyncope. Read More

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http://dx.doi.org/10.1152/ajpregu.00223.2018DOI Listing
February 2019
22 Reads

Maternal and environmental risk factors for neonatal AKI and its long-term consequences.

Nat Rev Nephrol 2018 Nov;14(11):688-703

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Acute kidney injury (AKI) is a common and life-threatening complication in critically ill neonates. Gestational risk factors for AKI include premature birth, intrauterine growth restriction and low birthweight, which are associated with poor nephron development and are often the consequence of pre-gestational and gestational factors, such as poor nutritional status. Our understanding of how to best optimize renal development and prevent AKI is in its infancy; however, the identification of pre-gestational and gestational factors that increase the risk of adverse neonatal outcomes and the implementation of interventions, such as improving nutritional status early in pregnancy, have the potential to optimize fetal growth and reduce the risk of preterm birth, thereby improving kidney health. Read More

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http://dx.doi.org/10.1038/s41581-018-0054-yDOI Listing
November 2018
18 Reads

Exclusive breast feeding and dehydration fever in newborns during the first days of life.

J Matern Fetal Neonatal Med 2018 Sep 10:1-5. Epub 2018 Sep 10.

a Division of Pediatrics , Thomas Jefferson University/Nemours , Philadelphia , PA , USA.

Objectives: To determine the prevalence of dehydration fever in infants admitted to the Neonatal Intensive Care Unit (NICU) from the well newborn nursery with fever in the first days of life.

Study Design: Retrospective data analysis of term infants admitted to the NICU from the well newborn nursery with fever (n = 75). Infants were divided into two groups based on hydration status using clinical and laboratory signs of dehydration. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1497605DOI Listing
September 2018
12 Reads

Filtered sunlight versus intensive electric powered phototherapy in moderate-to-severe neonatal hyperbilirubinaemia: a randomised controlled non-inferiority trial.

Lancet Glob Health 2018 Oct 28;6(10):e1122-e1131. Epub 2018 Aug 28.

Bowen University Teaching Hospital, Ogbomosho, Oyo, Nigeria.

Background: Kernicterus resulting from severe neonatal hyperbilirubinaemia is a leading cause of preventable deaths and disabilities in low-income and middle-income countries, partly because high-quality intensive phototherapy is unavailable. Previously, we showed that filtered-sunlight phototherapy (FSPT) was efficacious and safe for treatment of mild-to-moderate neonatal hyperbilirubinaemia. We aimed to extend these studies to infants with moderate-to-severe hyperbilirubinaemia. Read More

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http://dx.doi.org/10.1016/S2214-109X(18)30373-5DOI Listing
October 2018
5 Reads

Incidence of pathologic postobstructive diuresis after resolution of ureteropelvic junction obstruction with a normal contralateral kidney.

J Pediatr Urol 2018 Dec 24;14(6):557.e1-557.e6. Epub 2018 Jul 24.

Division of Pediatric Urology, Riley Hospital for Children, Indiana University School of Medicine, 705 Riley Hospital Drive, Suite 4230, Indianapolis, IN, 46202, USA.

Introduction: Postobstructive diuresis (POD) after unilateral pyeloplasty or percutaneous nephrostomy (PCN) tube insertion for ureteropelvic junction obstruction (UPJO) in patients with a normal contralateral kidney is not well described.

Objective: The objective of this study was to determine the incidence and characteristics of POD after relief of unilateral UPJO in patients with a normal contralateral kidney.

Study Design: Children who underwent a unilateral pyeloplasty or PCN for UPJO from 2010 to 2017 with a normal contralateral kidney were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.07.012DOI Listing
December 2018
17 Reads

Predicting Escalated Care in Infants With Bronchiolitis.

Pediatrics 2018 Sep 20;142(3). Epub 2018 Aug 20.

Division of Pediatric Emergency Medicine, and

Background And Objectives: Early risk stratification of infants with bronchiolitis receiving airway support is critical for focusing appropriate therapies, yet the tools to risk categorize this subpopulation do not exist. Our objective was to identify predictors of "escalated care" in bronchiolitis. We hypothesized there would be a significant association between escalated care and predictors in the emergency department. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2017-4253DOI Listing
September 2018
20 Reads
5.473 Impact Factor

Remnant Small Bowel Length in Pediatric Short Bowel Syndrome and the Correlation with Intestinal Dysbiosis and Linear Growth.

J Am Coll Surg 2018 Oct 2;227(4):439-449. Epub 2018 Aug 2.

Department of Surgery, Washington University, School of Medicine, St Louis, MO. Electronic address:

Background: Pediatric short bowel syndrome (SBS) is a malabsorptive state placing patients at risk for malnutrition, dehydration, and bacterial overgrowth. These patients are often dependent on parenteral nutrition (PN) while intestinal adaptation is underway. The aim of this study was to characterize the effect of remnant small bowel length on the gut microbiome. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.07.657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162148PMC
October 2018
4 Reads

Thirty-day hospital readmissions after augmentation cystoplasty: A Nationwide readmissions database analysis.

J Pediatr Urol 2018 Dec 4;14(6):533.e1-533.e9. Epub 2018 Jul 4.

Department of Pediatrics, Mercy Hospital St. Louis, St. Louis, MO, USA.

Introduction: Reducing hospital readmissions is a growing priority for hospitals and clinicians in their efforts to improve quality of care and curtail costs. Augmentation cystoplasty is among the most complex and high-morbidity operations in pediatric urology, with up to 25% of patients experiencing a postoperative complication. However, there is a paucity of literature addressing the incidence and characteristics of hospital readmissions after these procedures. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.05.028DOI Listing
December 2018
2 Reads

Influence of physical activity on hydration state in children with obesity before and after a weight loss program.

Acta Clin Belg 2018 Jul 20:1-6. Epub 2018 Jul 20.

f Pediatric nephrology , Zeepreventorium De Haan , De Haan , Belgium.

Objective: Evaluate the effect of a 1-year standardized residential slimming program on exercise-induced dehydration in children with obesity.

Method: At the start (T) and end (T) of the program, urine samples, weight, blood pressure and pulse were collected before (T) and after a Cooper test (T). Urinary samples were analyzed for volume, Na (U), Cl, K (U), urea, creatinine (U), protein and osmolality (U). Read More

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http://dx.doi.org/10.1080/17843286.2018.1493167DOI Listing
July 2018
16 Reads

Recurrent Encephalopathy During Febrile Illnesses in a 6-Year-Old Boy.

Glob Pediatr Health 2018 10;5:2333794X18784203. Epub 2018 Jul 10.

Wake Forest University, Winston-Salem, NC, USA.

Acute onset of encephalopathy is often due to infections or intoxications, but a high index of suspicion should exist for metabolic or autoimmune causes particularly in recurrent cases. A 6-year-old previously healthy Caucasian male presented with confusion and somnolence. He had several days of fever, myalgia, headaches, and rhinorrhea and was influenza-A positive. Read More

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http://dx.doi.org/10.1177/2333794X18784203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041993PMC
July 2018
10 Reads

Fetal gene therapy for neurodegenerative disease of infants.

Nat Med 2018 Sep 16;24(9):1317-1323. Epub 2018 Jul 16.

UCL School of Pharmacy, University College London, London, UK.

For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal pathological change. To explore this, we studied neuronopathic Gaucher disease (nGD), caused by mutations in GBA. In adult patients, the milder form presents with hepatomegaly, splenomegaly and occasional lung and bone disease; this is managed, symptomatically, by enzyme replacement therapy. Read More

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http://dx.doi.org/10.1038/s41591-018-0106-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130799PMC
September 2018
17 Reads
27.363 Impact Factor

Maternal knowledge, attitude and practices during childhood diarrhoea.

Trop Doct 2018 Oct 17;48(4):298-300. Epub 2018 Jul 17.

3 Resident, Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

Diarrhoea and pneumonia account for most deaths in children aged < 5 years. However, most diarrhoeal deaths are preventable with appropriate hygienic measures and timely initiation of rehydration therapy. A cross-sectional study was conducted on 280 mothers with children aged 2-59 months with acute watery diarrhoea at a tertiary hospital. Read More

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http://dx.doi.org/10.1177/0049475518787425DOI Listing
October 2018
24 Reads

Inflammation in cystic fibrosis: An update.

Pediatr Pulmonol 2018 Nov 12;53(S3):S30-S50. Epub 2018 Jul 12.

Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio.

Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease progression making it an active area of research and important therapeutic target. In this review, we explore the most recent research on the major contributors to the exuberant inflammatory response seen in CF as well as potential therapeutics to combat this response. Absence of functional cystic fibrosis transmembrane conductance regulator (CFTR) alters anion transport across CF airway epithelial cells and ultimately results in dehydration of the airway surface liquid. Read More

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http://dx.doi.org/10.1002/ppul.24129DOI Listing
November 2018
8 Reads

Clinical Scales for Assessment of Dehydration in Children with Diarrhea: Pediatrician's Viewpoint.

Authors:
Shivani Deswal

Indian Pediatr 2018 06;55(6):517-518

Department of Pediatrics, PGIMER and Dr RML Hospital, New Delhi, India.

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June 2018
14 Reads

Clinical Scales for Assessment of Dehydration in Children with Diarrhea: Evidence-based Medicine Viewpoint.

Authors:
Joseph L Mathew

Indian Pediatr 2018 06;55(6):513-516

Department of Pediatrics, PGIMER, Chandigarh, India.

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June 2018
4 Reads

Risk factors for mortality and effect of correct fluid prescription in children with diarrhoea and dehydration without severe acute malnutrition admitted to Kenyan hospitals: an observational, association study.

Lancet Child Adolesc Health 2018 Jul;2(7):516-524

Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

Background: Diarrhoea causes many deaths in children younger than 5 years and identification of risk factors for death is considered a global priority. The effectiveness of currently recommended fluid management for dehydration in routine settings has also not been examined.

Methods: For this observational, association study, we analysed prospective clinical data on admission, immediate treatment, and discharge of children age 1-59 months with diarrhoea and dehydration, which were routinely collected from 13 Kenyan hospitals. Read More

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http://dx.doi.org/10.1016/S2352-4642(18)30130-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004535PMC
July 2018
17 Reads

Caregiver oral rehydration solution fluid monitoring charts versus standard care for the management of some dehydration among Kenyan children: a randomized controlled trial.

Int Health 2018 11;10(6):442-450

Department of Paediatrics and Child Health, University of Nairobi, Kenya.

Background: Diarrhoea is a major cause of child mortality. Although oral rehydration solution (ORS) is an efficacious intervention for correcting dehydration, inadequate monitoring may limit its effectiveness in routine settings. We evaluated the effect of using a caregiver-administered chart to monitor oral fluid therapy on hydration status among children with some dehydration. Read More

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https://academic.oup.com/inthealth/article/10/6/442/5046090
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http://dx.doi.org/10.1093/inthealth/ihy040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204764PMC
November 2018
10 Reads

Involvement of bilateral posterior limb of internal capsule in hypernatraemic dehydration.

BMJ Case Rep 2018 Jun 23;2018. Epub 2018 Jun 23.

Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh UT, India.

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http://dx.doi.org/10.1136/bcr-2018-225101DOI Listing
June 2018
5 Reads

Long-term outcomes after cholecystocolostomy for progressive familial intrahepatic cholestasis.

Hepatol Res 2018 Dec 27;48(13):1163-1171. Epub 2018 Jul 27.

Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, China.

Aim: To evaluate the long-term efficacy of cholecystocolostomy surgery for progressive familial intrahepatic cholestasis (PFIC).

Methods: From August 2003 to November 2014, 34 clinically diagnosed children, including 11 with familial intrahepatic cholestasis-1 (FIC1), 13 with bile salt export pump (BSEP) disease, five with low γ-glutamyl transpeptidase (GGT) disease (levels <100 U/L), and five with multidrug resistance class III (MDR3) disease with high GGT (>100 U/L), were identified in our center. Data were collected retrospectively from individuals who collectively had 36 surgical operations and two orthotopic liver transplantations (OLT). Read More

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http://dx.doi.org/10.1111/hepr.13222DOI Listing
December 2018
17 Reads

[Rotavirus prevalence and genotype distribution in children with acute gastroenteritis in Adana province].

Mikrobiyol Bul 2018 Apr;52(2):156-165

Ankara Yildirim Beyazit University Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.

Rotavirus is the most common agent of acute gastroenteritis in children under five years of age and still a major cause of mortality and morbidity mainly in devoloping countries. The aim of this study was to determine the circulating rotavirus genotypes in children less than five years of age with acute gastroenteritis in Adana province, before the introduction of the rotavirus vaccine into the national immunization programme. Fecal specimens were collected from children enrolled between December 2012 and November 2016 and rotavirus antigen was searched by a rapid immunochromatographic test method. Read More

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http://dx.doi.org/10.5578/mb.66648DOI Listing
April 2018
7 Reads

Ischaemic Haemorrhagic Stroke in a Child with New Onset Type 1 Diabetes Mellitus.

Eur Endocrinol 2018 Apr 18;14(1):59-61. Epub 2018 Apr 18.

University Malaya Pediatric and Child Health Research Group, University Malaya, Kuala Lumpur, Malaysia.

Cerebral oedema is the most common neurological complication of diabetic ketoacidosis (DKA). However, ischaemic and haemorrhagic brain injury has been reported infrequently. A 10-year old girl who was previously well presented with severe DKA. Read More

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http://dx.doi.org/10.17925/EE.2018.14.1.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954598PMC
April 2018
3 Reads