1,438 results match your criteria Pediatrics Dehydration


Diarrhea, Dehydration, and the Associated Mortality in Children with Complicated Severe Acute Malnutrition: A Prospective Cohort Study in Uganda.

J Pediatr 2019 Apr 13. Epub 2019 Apr 13.

Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen, Denmark.

Objective: To assess predictors of diarrhea and dehydration and to investigate the role of diarrhea in mortality among children with complicated severe acute malnutrition.

Study Design: A prospective cohort study, nested in a probiotic trial, was conducted in children with complicated severe acute malnutrition. Children were treated according to World Health Organization and national guidelines, and diarrhea and dehydration were assessed daily. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.03.014DOI Listing

Initiating the ketogenic diet in infants with treatment refractory epilepsy while maintaining a breast milk diet.

Seizure 2019 Mar 26;69:41-43. Epub 2019 Mar 26.

Children's Mercy Hospital, Division of Neurology, Kansas City, United States.

Purpose: The ketogenic diet has been found to be safe and effective in the treatment of drug resistant epilepsy in childhood. The age range of children undergoing this treatment has steadily been going down. There is strong evidence that it is a safe alternative in infants with drug resistant seizures. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.017DOI Listing
March 2019
1 Read

Surveys of parents and clinicians concerning the minimally important difference of probiotic therapy for prevention of paediatric antibiotic-associated diarrhoea.

BMJ Open 2019 Apr 2;9(4):e024651. Epub 2019 Apr 2.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To establish the minimally important difference (MID) that would prompt parents and clinicians to use probiotics for prevention of paediatric antibiotic-associated diarrhoea (AAD) and to obtain parent and clinician opinion about the most important outcomes in clinical trials of AAD.

Methods: In this survey, parents of children presenting to the emergency department of a Canadian tertiary care children's hospital and paediatricians working in that hospital were approached. A range of potential MIDs were presented and participants selected one that they would require to use probiotics for AAD prevention. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024651DOI Listing
April 2019
2 Reads
2.063 Impact Factor

Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.

Ann Pediatr Endocrinol Metab 2019 Mar 31;24(1):64-67. Epub 2019 Mar 31.

Department of Pediatrics, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Idiopathic infantile hypercalcemia is characterized by hypercalcemia, dehydration, vomiting, and failure to thrive, and it is due to mutations in 24-hydroxylase (CYP24A1). Recently, mutations in sodium-phosphate cotransporter (SLC34A1) expressed in the kidney were discovered as an additional cause of idiopathic infantile hypercalcemia. This report describes a female infant admitted for evaluation of nephrocalcinosis. Read More

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http://dx.doi.org/10.6065/apem.2019.24.1.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449619PMC
March 2019
1 Read

Methamphetamine-Induced Tachydysrhythmia in an Adolescent in Diabetic Ketoacidosis.

J Emerg Med 2019 Mar 14. Epub 2019 Mar 14.

Division of Emergency and Transport Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: Diabetic ketoacidosis (DKA) is a common complication affecting patients with type 1 diabetes, and DKA is associated with dehydration and electrolyte abnormalities. Supraventricular tachycardia (SVT), although a common tachydysrhythmia in the pediatric population, remains a rare entity in patients presenting with DKA.

Case Report: We describe a case of first-time SVT in an adolescent patient with DKA and recent methamphetamine abuse, with both factors likely predisposing him to develop a tachydysrhythmia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679193003
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http://dx.doi.org/10.1016/j.jemermed.2019.01.031DOI Listing
March 2019
6 Reads

Exclusive breastfeeding and postnatal changes in blood sodium, ketone, and glucose levels.

Pediatr Int 2019 Mar 10. Epub 2019 Mar 10.

Department of Pediatrics, Toyama Prefectural Central Hospital.

Background: Blood sodium and ketone levels are parameters of dehydration and fasting, respectively. However, little is known about the postnatal changes in these parameters that occur in healthy, term, exclusively breastfed neonates.

Methods: Capillary blood sodium, beta-hydroxybutyrate (βOHB), and glucose levels in 628 samples obtained from 392 healthy, term, exclusively breastfed neonates during the first 12 to 143 hours of life were examined. Read More

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http://dx.doi.org/10.1111/ped.13824DOI Listing
March 2019
2 Reads

Preventive effect of purgative manna on neonatal jaundice: A double blind randomized controlled clinical trial.

J Ethnopharmacol 2019 May 8;236:240-249. Epub 2019 Mar 8.

Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Ethnopharmacological Relevance: Cotoneaster nummularioides Pojark manna (Shir-e-Khesht) is popular in Persian medicine. Different effects of some Cotoneaster species manna include antibacterial, antioxidant, anticancer, and hepatoprotective effects, as well as bilirubin serum levels reduction. Cotoneaster species manna is used in many parts of Iran as a laxative and accelerates the passage of meconium. Read More

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http://dx.doi.org/10.1016/j.jep.2019.03.009DOI Listing
May 2019
1 Read
2.998 Impact Factor

Prevalence and factors associated with renal dysfunction in children admitted to two hospitals in northwestern Tanzania.

BMC Nephrol 2019 Mar 5;20(1):79. Epub 2019 Mar 5.

Department of Pediatrics and Child Health, Bugando Medical Centre, P. O. Box 1370, Mwanza, Tanzania.

Background: It is evident that renal dysfunction (RD) is associated with unique infectious and non-infectious causes in African children. However, little data exists about the prevalence and factors associated with RD in children admitted to African hospitals.

Methods: In this cross-sectional study, we enrolled all children admitted to pediatric wards of Bugando Medical Centre (BMC) and Sekou-Toure Regional Referral hospital (SRRH) during a 6 month time period. Read More

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http://dx.doi.org/10.1186/s12882-019-1254-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402082PMC
March 2019
7 Reads
1.520 Impact Factor

Hyperglycemic hyperosmolar state in an adolescent with type 1 diabetes mellitus.

Endocrinol Diabetes Metab Case Rep 2019 Mar 5;2019. Epub 2019 Mar 5.

Department of Pediatrics, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.

Hyperglycemic hyperosmolar state (HHS) and diabetic ketoacidosis (DKA) are the most severe acute complications of diabetes mellitus (DM). HHS is characterized by severe hyperglycemia and hyperosmolality without significant ketosis and acidosis. A 14-year-old Japanese boy presented at the emergency room with lethargy, polyuria and polydipsia. Read More

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http://dx.doi.org/10.1530/EDM-18-0131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432974PMC
March 2019
4 Reads

Comparison of Risk Factors for Pediatric Kidney Stone Formation: The Effects of Sex.

Front Pediatr 2019 12;7:32. Epub 2019 Feb 12.

Division of Nephrology, Akron Children's Hospital, Akron, OH, United States.

Urinary stones are affecting more children, and pediatric stone formers have unique pathophysiology compared to adults. While adult stone formers are most frequently male, children have an age dependent sex prevalence. Under 10 years, a majority of stone formers are boys; adolescent stone formers are mostly female. Read More

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http://dx.doi.org/10.3389/fped.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379338PMC
February 2019
2 Reads

Dehydration: A Multidisciplinary Case-Based Discussion for First-Year Medical Students.

MedEdPORTAL 2018 Jun 26;14:10725. Epub 2018 Jun 26.

Assistant Professor, Pediatrics and Cancer Biology and Pharmacology Department, University of Illinois College of Medicine.

Introduction: As many medical school curricula shift to integrated learning of multiple basic science topics as well as clinical concepts, there is an increasing need for instructional materials that incorporate multiple topics yet are targeted to the knowledge basis of first-year medical students. This interactive case-based session for first-year medical students centers on the clinical presentation and initial evaluation of a patient experiencing dehydration after running a marathon in a high-altitude city.

Methods: After completion of assigned out-of-class preparation, students followed the patient from a healthy state to moderate dehydration over the course of two 2-hour class sessions. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342389PMC

Hypovolemic Shock in a Child: A Pediatric Simulation Case.

MedEdPORTAL 2018 Mar 16;14:10694. Epub 2018 Mar 16.

Professor, Department of Pediatrics, Robert Larner, MD, College of Medicine at the University of Vermont.

Introduction: Volume depletion is a common problem in pediatrics. Interns need to be able to recognize critical illness such as hypovolemic shock, obtain access, and manage complications. This simulation case involves a child with hypovolemic shock who requires intraosseous (IO) needle placement. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342355PMC
March 2018
2 Reads

Approaches to Reduce Sports Drink Consumption Among Adolescents.

Authors:
Nicole D White

Am J Lifestyle Med 2019 Mar-Apr;13(2):145-147. Epub 2018 Dec 10.

Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska.

Sports drinks originally developed to improve performance and prevent or treat dehydration, heat stroke, and muscle cramps in elite athletes are consumed regularly by nearly 60% of the adolescent population. Sports drinks are often perceived as healthy, and marketing campaigns fail to delineate the types and amount of activity that warrant appropriate use. Current trends in adolescent consumption of sports drinks will be reviewed and approaches to reduce consumption, including counseling on the appropriate use of sports drinks, will be discussed. Read More

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http://dx.doi.org/10.1177/1559827618815808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378499PMC
December 2018

Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration.

Sci Rep 2019 Feb 12;9(1):1873. Epub 2019 Feb 12.

Institute for Integrative Toxicology at Michigan State University, East Lansing, 48824, MI, USA.

The lateral hypothalamic area (LHA) is essential for ingestive behavior but it remains unclear how LHA neurons coordinate feeding vs. drinking. Most LHA populations promote food and water consumption but LHA neurotensin (Nts) neurons preferentially induce water intake while suppressing feeding. Read More

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http://www.nature.com/articles/s41598-018-38143-9
Publisher Site
http://dx.doi.org/10.1038/s41598-018-38143-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372669PMC
February 2019
6 Reads

Vomiting and Dehydration in a 2-Year-Old.

Pediatrics 2019 Mar 12;143(3). Epub 2019 Feb 12.

Divisions of Emergency Medicine and.

A 2-year-old girl with a past medical history of cutaneous mastocytosis and eczema presented with 1 day of yellow-green, nonbloody vomiting, bradycardia, and listlessness. She was evaluated by her pediatrician and sent to the emergency department because of concern for dehydration. In the emergency department, she improved with fluid rehydration but still had decreased energy and bradycardia. Read More

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http://dx.doi.org/10.1542/peds.2018-0504DOI Listing
March 2019
7 Reads

Medical Assessment and Triage of Pediatric Patients with Anorexia Nervosa in Primary Care.

J Dev Behav Pediatr 2019 Feb/Mar;40(2):92-98

Division of Internal Medicine and Pediatrics, University of California, Los Angeles, CA.

Objective: To examine the medical assessment and triage of pediatric patients with anorexia nervosa (AN) initially seen in primary care.

Methods: A retrospective cohort study was conducted for all pediatric patients with AN who had eating/weight concerns and initially identified symptoms in primary care in a single health care system between January 1, 2010, and December 31, 2016. Information on presenting concern, medical assessment/laboratory tests, clinical diagnoses, treatment recommendations, and referrals were abstracted from the medical record. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000629DOI Listing
February 2019
4 Reads

Celiac crisis, a rare occurrence in adult celiac disease: A systematic review.

World J Clin Cases 2019 Feb;7(3):311-319

Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.

Background: Celiac crisis (CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease (CD). Several cases have been documented in the literature, mostly in children.

Aim: To perform a review of CC cases reported in adult CD patients. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i3.311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369385PMC
February 2019
3 Reads

Congenital adrenal hyperplasia with salt-wasting crisis and arrhythmia: a case study.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of Paediatrics, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK.

We report a case of a 10-day-old male infant who presented to the emergency department with severe electrolyte imbalance and life-threatening arrhythmia. The parents reported a 3-day history of poor feeding and lethargy. On examination, he was bradycardic (heart rate of 65 beats/min) with signs of dehydration. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22756
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-227565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352754PMC
January 2019
48 Reads

Does the addition of dextrose to IV crystalloid therapy provide clinical benefit in acute dehydration? A systematic review and meta-analysis.

CJEM 2019 Jan 30:1-8. Epub 2019 Jan 30.

†Department of Emergency Medicine,Indiana University School of Medicine,Indianapolis, IN.

Objectives: Intravenous dextrose aids in the resolution of ketosis in dehydrated patients not tolerating oral glucose and is often recommended in this clinical scenario. Our aim was to determine whether the addition of dextrose to intravenous rehydration solutions results in decreased hospital admissions or other clinically important benefits among dehydrated children or adults.

Methods: MEDLINE, EMBASE, Web of Science, SCOPUS, and the Cochrane Library were searched by a medical librarian from inception through November 2017. Read More

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http://dx.doi.org/10.1017/cem.2018.500DOI Listing
January 2019
5 Reads

Congenital glucose-galactose malabsorption: A case report with a novel mutation.

Clin Case Rep 2019 Jan 11;7(1):51-53. Epub 2018 Nov 11.

Department of Pediatrics, School of Medicine The university of Jordan Amman Jordan.

A three-day-old newborn girl presented with decreased feeding and dehydration. She was sick and in shock. She had renal impairment and hypernatremia. Read More

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http://doi.wiley.com/10.1002/ccr3.1913
Publisher Site
http://dx.doi.org/10.1002/ccr3.1913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333054PMC
January 2019
22 Reads

Body hydration assessment using bioelectrical impedance vector analysis in neurologically impaired children.

Eur J Clin Nutr 2019 Jan 16. Epub 2019 Jan 16.

Paediatric Surgery Department, Children's Hospital "G. Di Cristina", ARNAS Civico-di Cristina-Benfratelli", Palermo, Italy.

Dehydration is common and frequently under-diagnosed in chronic malnourished children, leading to life-threatening conditions. In this pilot study we applied bioimpedance vector analysis (BIVA) to determine hydration status in 52 neurologically impaired (NI) paediatric patients (14.08 ± 5. Read More

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http://dx.doi.org/10.1038/s41430-018-0384-7DOI Listing
January 2019
4 Reads

Infant Botulism With Asymmetric Cranial Nerve Palsies.

Pediatr Neurol 2019 Mar 30;92:71-72. Epub 2018 Nov 30.

Baylor College of Medicine, Department of Pediatrics, Section of Neurology and Developmental Neuroscience, Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.016DOI Listing
March 2019
4 Reads

Malignant gastrointestinal neuroectodermal tumor (clear cell sarcoma-like tumor of the gastrointestinal tract) of the small intestine in a 12-year-old boy.

Dev Period Med 2018 ;22(4):358-363

Department of General Pathomorphology, Medical University of Białystok, Białystok, Poland.

The aim of this paper is a clinical and anatomopathological demonstration of a malignant lesion, a gastrointestinal neuroectodermal tumor (GNET), as an exceedingly rare cause of ileus in the pediatric population. Specifically, we present the case of a 12-year-old boy who showed dramatic weight loss, hypochromic anemia, fever, dehydration, exaggerated granulation of the terminal ileum, and mechanical ileus due to the obstruction by an intramural tumor of the small intestine. A 50cm-long part of the small intestine with pathological stricture was surgically removed, sampled and routinely fixed and stained with hematoxylin and eosin. Read More

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January 2018
2 Reads

Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients.

Kidney Res Clin Pract 2018 Dec 31;37(4):347-355. Epub 2018 Dec 31.

Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.

Background: Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) is a common complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression of NS. However, the incidence and risk factors of childhood-onset NS in Korea are unclear. Read More

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http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krc
Publisher Site
http://dx.doi.org/10.23876/j.krcp.18.0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312784PMC
December 2018
17 Reads

Collodion baby treated at a tertiary hospital in Tanzania: a case report.

J Med Case Rep 2018 Dec 31;12(1):385. Epub 2018 Dec 31.

Department of Paediatrics and Child health, School of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), 9 United Nations Road, Upanga West, P.O. Box 65001, Dar-es-salaam, Tanzania.

Background: The term "collodion baby" is used to describe a newborn covered with a translucent, parchment-like skin sheet. It is an extremely rare condition with an estimated incidence of 1 in 300,000 live births. Clinically, the baby will present with a collodion membrane with fissures, ectropium, eclabium, and hypoplastic digits. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13256-018-1912-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311898PMC
December 2018
13 Reads

Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.

Minerva Pediatr 2019 Feb;71(1):82-99

Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.

Unlike fever, which is often over-treated especially in children, pain is underestimated and under-treated in pediatric age. The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years. Paracetamol and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen are the most used at this purpose. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05453-1DOI Listing
February 2019
8 Reads

Milk feed osmolality and adverse events in newborn infants and animals: a systematic review.

Arch Dis Child Fetal Neonatal Ed 2018 Dec 6. Epub 2018 Dec 6.

Danone Nutricia Research, Utrecht, The Netherlands.

Background: High feed osmolality (or osmolarity) is often suggested to be linked with adverse gastrointestinal events in preterm infants.

Aim: To systematically review the literature on milk feed osmolality and adverse gastrointestinal events in newborn and low birthweight infants and animals.

Methods: MEDLINE, Embase, CAB Abstracts, Current Contents, BIOSIS Previews and SciSearch were searched from inception to May 2018 to identify potentially relevant studies. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315946DOI Listing
December 2018
3 Reads
3.120 Impact Factor

Introduction of an Oral Fluid Challenge Protocol in the Management of Children with Acute Gastroenteritis: A Regional Hospital Experience.

Ir Med J 2018 06 7;111(6):775. Epub 2018 Jun 7.

Academic Department of Paediatrics, National University of Ireland, Galway, Ireland

Oral rehydration therapy (ORT) remains the ideal first line therapy for acute gastroenteritis (AGE). Our aim was to assess the impact of introducing an Oral Fluid Challenge (OFC) protocol on outcomes such as intravenous fluid use and documentation in our institution. A single centre study with data collected retrospectively pre-implementation (April 2015) of the OFC protocol and post implementation (April 2016). Read More

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June 2018
8 Reads

Fanconi Syndrome.

Authors:
John W Foreman

Pediatr Clin North Am 2019 02;66(1):159-167

Department of Pediatrics, Duke University School of Medicine, Erwin Road, Durham, NC 27710, USA. Electronic address:

Fanconi syndrome, also known as the DeToni, Debré, Fanconi syndrome is a global dysfunction of the proximal tubule characterized by glucosuria, phosphaturia, generalized aminoaciduria, and type II renal tubular acidosis. Often there is hypokalemia, sodium wasting, and dehydration. In children, it typically is caused by inborn errors of metabolism, principally cystinosis. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.09.002DOI Listing
February 2019
2 Reads

Paediatric deaths in a tertiary government hospital setting, Malawi.

Paediatr Int Child Health 2018 Nov 19:1-9. Epub 2018 Nov 19.

g Centre for Medical Education , Queen's University , Belfast , UK.

Background: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS.

Aims: To determine the causes of inpatient child death including microbiological aetiologies in Malawi. Read More

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https://www.tandfonline.com/doi/full/10.1080/20469047.2018.1
Publisher Site
http://dx.doi.org/10.1080/20469047.2018.1536873DOI Listing
November 2018
19 Reads

Needs Assessment for Simulation Training for Prehospital Providers in Botswana.

Prehosp Disaster Med 2018 Dec 13;33(6):621-626. Epub 2018 Nov 13.

5Emergency Medical Services,Botswana Ministry of Health and Wellness,Gaborone,Botswana.

Background: In June 2012, the Botswana Ministry of Health and Wellness (MOHW; Gaborone, Botswana) initiated a national Emergency Medical Services (EMS) system in response to significant morbidity and mortality associated with prehospital emergencies. The MOHW requested external expertise to train its developing workforce. Simulation-based training was planned to equip these health care providers with clinical knowledge, procedural skills, and communication techniques. Read More

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http://dx.doi.org/10.1017/S1049023X18001024DOI Listing
December 2018
18 Reads

Oral Ondansetron Administration to Nondehydrated Children With Diarrhea and Associated Vomiting in Emergency Departments in Pakistan: A Randomized Controlled Trial.

Ann Emerg Med 2019 Mar 2;73(3):255-265. Epub 2018 Nov 2.

Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.

Study Objective: We determine whether single-dose oral ondansetron administration to children with vomiting as a result of acute gastroenteritis without dehydration reduces administration of intravenous fluid rehydration.

Methods: In this 2-hospital, double-blind, placebo-controlled, emergency department-based, randomized trial conducted in Karachi Pakistan, we recruited children aged 0.5 to 5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960644183126
Publisher Site
http://dx.doi.org/10.1016/j.annemergmed.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390170PMC
March 2019
7 Reads

Magnitude and pattern of improvement in processes of care for hospitalised children with diarrhoea and dehydration in Kenyan hospitals participating in a clinical network.

Trop Med Int Health 2019 Jan 11;24(1):73-80. Epub 2018 Nov 11.

Kenya Medical Research Institute/Wellcome Trust Research Programme, Nairobi, Kenya.

Objective: WHO recommends optimisation of available interventions to reduce deaths of under-five children with diarrhoea and dehydration (DD). Clinical networks may help improve practice across many hospitals but experience with such networks is scarce. We describe magnitude and patterns of changes in processes of care for children with DD over the first 3 years of a clinical network. Read More

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http://doi.wiley.com/10.1111/tmi.13176
Publisher Site
http://dx.doi.org/10.1111/tmi.13176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378700PMC
January 2019
13 Reads

Pediatric Dehydration Assessment at Triage: Prospective Study on Refilling Time.

Pediatr Gastroenterol Hepatol Nutr 2018 Oct 10;21(4):278-288. Epub 2018 Oct 10.

Pediatric Department, Ospedale "F. Del Ponte", University of Insubria, Varese, Italy.

Purpose: Dehydration is a paediatric medical emergency but there is no single standard parameter to evaluate it at the emergency department. Our aim was to evaluate the reliability and validity of capillary refilling time as a triage parameter to assess dehydration in children.

Methods: This was a prospective pilot cohort study of children who presented to two paediatric emergency departments in Italy, with symptoms of dehydration. Read More

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http://dx.doi.org/10.5223/pghn.2018.21.4.278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182472PMC
October 2018
2 Reads

The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis.

Curr Opin Pharmacol 2018 Dec 16;43:152-165. Epub 2018 Oct 16.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA; The Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Cystic fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR dysfunction is characterized by abnormal mucociliary transport due to a dehydrated airway surface liquid (ASL) and hyperviscous mucus, among other pathologies of host defense. ASL depletion is caused by the absence of CFTR mediated chloride secretion along with continued activity of the epithelial sodium channel (ENaC) activity, which can also be affected by CFTR mediated anion conductance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14714892183004
Publisher Site
http://dx.doi.org/10.1016/j.coph.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294660PMC
December 2018
19 Reads

Bronchiolitis clinics and medical treatment.

Minerva Pediatr 2018 Dec 18;70(6):600-611. Epub 2018 Oct 18.

Department of Pediatrics, Sapienza University, Rome, Italy.

Bronchiolitis is the most common acute lower respiratory tract infection in infants and the first cause of hospitalization in this age group. Despite it has been studied for over 70 years, its management remains controversial and nowadays the treatment is only supportive. Pediatricians should be well acquainted with the clinical course of the disease. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05334-3DOI Listing
December 2018
12 Reads

Severe Acute Kidney Injury and Multiple Organ Failure in a 17-Day-Old Newborn: When Pathology Makes the Difference.

Can J Kidney Health Dis 2018 6;5:2054358118804834. Epub 2018 Oct 6.

Division of Nephrology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, QC, Canada.

Rationale: Acute tubulointerstitial nephritis (ATIN) in children is most commonly due to allergic drug reactions. In neonates, diagnosis of ATIN is clinically suspected and a kidney biopsy is not routinely performed.

Presenting Concern: A 17-day-old newborn presented with vomiting and dehydration, along with anuric acute kidney injury, severe electrolyte disturbances, hypocomplementemia, and thrombocytopenia. Read More

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http://dx.doi.org/10.1177/2054358118804834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174648PMC
October 2018
4 Reads

Chinese clinical practice guidelines for acute infectious diarrhea in children.

World J Pediatr 2018 Oct 29;14(5):429-436. Epub 2018 Sep 29.

Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China.

Background: The guidelines addressed the evidence-based indications for the management of children with acute infectious diarrhea in Chinese pediatric population.

Data Sources: The experts group of evidence development put forward clinical problems, collects evidence, forms preliminary recommendations, and then uses open-ended discussions to form recommendations. The literature review was done for developing this guideline in databases including PubMed, Cochrane, EMBASE, China Biomedical Database, and Chinese Journal Full-text Database up to June 2013. Read More

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http://dx.doi.org/10.1007/s12519-018-0190-2DOI Listing
October 2018
20 Reads

Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study.

Eur J Pediatr 2018 Dec 24;177(12):1837-1844. Epub 2018 Sep 24.

Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.

Diarrhea-associated hemolytic uremic syndrome is characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury secondary to enteric infection, typically Shiga toxin-producing Escherichia coli. Shiga toxin 2 is able to activate alternative complement pathways; therefore, the aim of the study was to analyze C3 as a predictor of clinical courses in patients with diarrhea-associated hemolytic uremic syndrome. We hypothesized that the patients with increased complement activation at admission suffered from a more severe course. Read More

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http://dx.doi.org/10.1007/s00431-018-3255-2DOI Listing
December 2018
13 Reads
1.983 Impact Factor

Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stressed humans.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 19;316(2):R145-R156. Epub 2018 Sep 19.

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital of Dallas , Dallas, Texas.

Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses would be increased by passive heat stress, as well as exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult. In aim 1, subjects were exposed to passive heating or normothermic time control, each followed by progressive lower-body negative pressure (LBNP) to presyncope. Read More

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http://dx.doi.org/10.1152/ajpregu.00223.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397353PMC
February 2019
31 Reads

Maternal and environmental risk factors for neonatal AKI and its long-term consequences.

Nat Rev Nephrol 2018 Nov;14(11):688-703

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Acute kidney injury (AKI) is a common and life-threatening complication in critically ill neonates. Gestational risk factors for AKI include premature birth, intrauterine growth restriction and low birthweight, which are associated with poor nephron development and are often the consequence of pre-gestational and gestational factors, such as poor nutritional status. Our understanding of how to best optimize renal development and prevent AKI is in its infancy; however, the identification of pre-gestational and gestational factors that increase the risk of adverse neonatal outcomes and the implementation of interventions, such as improving nutritional status early in pregnancy, have the potential to optimize fetal growth and reduce the risk of preterm birth, thereby improving kidney health. Read More

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http://dx.doi.org/10.1038/s41581-018-0054-yDOI Listing
November 2018
21 Reads

Exclusive breast feeding and dehydration fever in newborns during the first days of life.

J Matern Fetal Neonatal Med 2018 Sep 10:1-5. Epub 2018 Sep 10.

a Division of Pediatrics , Thomas Jefferson University/Nemours , Philadelphia , PA , USA.

Objectives: To determine the prevalence of dehydration fever in infants admitted to the Neonatal Intensive Care Unit (NICU) from the well newborn nursery with fever in the first days of life.

Study Design: Retrospective data analysis of term infants admitted to the NICU from the well newborn nursery with fever (n = 75). Infants were divided into two groups based on hydration status using clinical and laboratory signs of dehydration. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1497605DOI Listing
September 2018
14 Reads

Filtered sunlight versus intensive electric powered phototherapy in moderate-to-severe neonatal hyperbilirubinaemia: a randomised controlled non-inferiority trial.

Lancet Glob Health 2018 10 28;6(10):e1122-e1131. Epub 2018 Aug 28.

Bowen University Teaching Hospital, Ogbomosho, Oyo, Nigeria.

Background: Kernicterus resulting from severe neonatal hyperbilirubinaemia is a leading cause of preventable deaths and disabilities in low-income and middle-income countries, partly because high-quality intensive phototherapy is unavailable. Previously, we showed that filtered-sunlight phototherapy (FSPT) was efficacious and safe for treatment of mild-to-moderate neonatal hyperbilirubinaemia. We aimed to extend these studies to infants with moderate-to-severe hyperbilirubinaemia. Read More

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http://dx.doi.org/10.1016/S2214-109X(18)30373-5DOI Listing
October 2018
6 Reads

Incidence of pathologic postobstructive diuresis after resolution of ureteropelvic junction obstruction with a normal contralateral kidney.

J Pediatr Urol 2018 Dec 24;14(6):557.e1-557.e6. Epub 2018 Jul 24.

Division of Pediatric Urology, Riley Hospital for Children, Indiana University School of Medicine, 705 Riley Hospital Drive, Suite 4230, Indianapolis, IN, 46202, USA.

Introduction: Postobstructive diuresis (POD) after unilateral pyeloplasty or percutaneous nephrostomy (PCN) tube insertion for ureteropelvic junction obstruction (UPJO) in patients with a normal contralateral kidney is not well described.

Objective: The objective of this study was to determine the incidence and characteristics of POD after relief of unilateral UPJO in patients with a normal contralateral kidney.

Study Design: Children who underwent a unilateral pyeloplasty or PCN for UPJO from 2010 to 2017 with a normal contralateral kidney were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.07.012DOI Listing
December 2018
22 Reads

Predicting Escalated Care in Infants With Bronchiolitis.

Pediatrics 2018 Sep 20;142(3). Epub 2018 Aug 20.

Division of Pediatric Emergency Medicine, and

Background And Objectives: Early risk stratification of infants with bronchiolitis receiving airway support is critical for focusing appropriate therapies, yet the tools to risk categorize this subpopulation do not exist. Our objective was to identify predictors of "escalated care" in bronchiolitis. We hypothesized there would be a significant association between escalated care and predictors in the emergency department. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2017-4253DOI Listing
September 2018
23 Reads
5.473 Impact Factor

Remnant Small Bowel Length in Pediatric Short Bowel Syndrome and the Correlation with Intestinal Dysbiosis and Linear Growth.

J Am Coll Surg 2018 Oct 2;227(4):439-449. Epub 2018 Aug 2.

Department of Surgery, Washington University, School of Medicine, St Louis, MO. Electronic address:

Background: Pediatric short bowel syndrome (SBS) is a malabsorptive state placing patients at risk for malnutrition, dehydration, and bacterial overgrowth. These patients are often dependent on parenteral nutrition (PN) while intestinal adaptation is underway. The aim of this study was to characterize the effect of remnant small bowel length on the gut microbiome. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.07.657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162148PMC
October 2018
5 Reads

Thirty-day hospital readmissions after augmentation cystoplasty: A Nationwide readmissions database analysis.

J Pediatr Urol 2018 Dec 4;14(6):533.e1-533.e9. Epub 2018 Jul 4.

Department of Pediatrics, Mercy Hospital St. Louis, St. Louis, MO, USA.

Introduction: Reducing hospital readmissions is a growing priority for hospitals and clinicians in their efforts to improve quality of care and curtail costs. Augmentation cystoplasty is among the most complex and high-morbidity operations in pediatric urology, with up to 25% of patients experiencing a postoperative complication. However, there is a paucity of literature addressing the incidence and characteristics of hospital readmissions after these procedures. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.05.028DOI Listing
December 2018
2 Reads