17,771 results match your criteria Pediatrics Chicken Pox or Varicella


Trends in varicella and herpes zoster epidemiology before and after the implementation of universal one-dose varicella vaccination over one decade in South Korea, 2003-2015.

Hum Vaccin Immunother 2019 Apr 22. Epub 2019 Apr 22.

b Vaccine Bio Research Institute, College of Medicine , The Catholic University of Korea , Seoul , Republic of Korea.

Background In South Korea, one-dose varicella vaccine was included in the National Immunization Program for children aged 12-15 months in 2005, and the vaccine coverage reached >95%. The impact of varicella vaccination on varicella and herpes zoster (HZ) was investigated, accounting for demographic changes over time. Methods We calculated the crude and age-sex standardized incidence rates (IRs) and age-specific IRs of varicella and HZ from 2003 to 2015, using the National Health Information Database including approximately 50 million Koreans. Read More

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http://dx.doi.org/10.1080/21645515.2019.1603985DOI Listing

[Methodology of the 2nd seroprevalence study in Spain].

Rev Esp Salud Publica 2019 Apr 22;93. Epub 2019 Apr 22.

Subdirección General de Promoción de la Salud y Vigilancia en Salud Pública. Dirección General de Salud Pública, Calidad e Innovación. Ministerio de Sanidad, Consumo y Bienestar Social. Madrid. España.

Seroprevalence studies are designed in population samples to assess the level and distribution of immunity induced by natural infection of certain infectious agents or by immunization against them. The purpose of the 2nd Seroprevalence Study in Spain is to assess the prevalence and distribution of immune status against vaccine-preventable diseases and generated by natural infection by other microorganisms. Pathologies specifically included in the study are: poliomyelitis, diphtheria, tetanus, pertussis, measles, rubella, mumps, varicella, invasive meningococcal disease by serogroup C, hepatitis A, hepatitis B, hepatitis E, hepatitis C and HIV. Read More

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[Trends on the epidemics of acute meningitis and encephalitis among population under 18 years-old in Shijiazhuang city, 2007-2017].

Authors:
J H Guo J Li X Zhang

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):417-421

Hebei Provincial Children Hospital, Shijiazhuang 050030, China.

To understand the trends on the epidemics of acute meningitis and encephalitis (AME) among children under 18 years-old in Shijiazhuang city, 2007-2017. Surveillance programs on acute meningitis and encephalitis (AMES) had been conducted in population less than 18 years-old, since 2007. Hospitals at county level or above in Shijiazhuang had been included to carry out the epidemiologic surveillance, including 6 on pathogens, regarding AMES. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.009DOI Listing

Vaccination of the Stem Cell Transplant Recipient and the Hematologic Malignancy Patient.

Infect Dis Clin North Am 2019 Jun;33(2):593-609

Infectious Disease Service, Department of Medicine, Weill Cornell Medical College, 275 York Avenue, Box 420, New York, NY 10065, USA.

Patients with hematologic malignancy or those who undergo hematopoietic stem cell transplantation experience variable degrees of immunosuppression, dependent on underlying disease, therapy received, time since transplant, and complications, such as graft-versus-host disease. Vaccination is an important strategy to mitigate onset and severity of certain vaccine-preventable illnesses, such as influenza, pneumococcal disease, or varicella zoster infection, among others. This article highlights vaccines that should and should not be used in this patient population and includes general guidelines for timing of vaccination administration and special considerations in the context of newer therapies, recent vaccine developments, travel, and considerations for household contacts. Read More

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http://dx.doi.org/10.1016/j.idc.2019.02.007DOI Listing

Herpes Virus Infections Other than Cytomegalovirus in the Recipients of Hematopoietic Stem Cell Transplantation.

Infect Dis Clin North Am 2019 Jun;33(2):467-484

City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address:

This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. Read More

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http://dx.doi.org/10.1016/j.idc.2019.02.012DOI Listing

Severe Herpes Zoster Requiring Intravenous Antiviral Treatment in Allogeneic Hematopoietic-cell Transplantation Recipients on Standard Acyclovir Prophylaxis.

Biol Blood Marrow Transplant 2019 Apr 17. Epub 2019 Apr 17.

Brigham and Women's Hospital, Department of Infectious Diseases, Boston, Massachusetts; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts.

Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk for varicella zoster virus reactivation and associated complications. The incidence, timing, and risk factors for severe herpes zoster (HZ) are not well described in the era of acyclovir (ACV) prophylaxis. We performed a retrospective cohort study of all patients who underwent first allogeneic HCT from October 2006 to December 2015 at our institution. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.015DOI Listing

Vaccination of Solid Organ Transplant Candidates and Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Apr 19:e13563. Epub 2019 Apr 19.

Transplant Infectious Diseases, University Health Network, Toronto, ON.

These updated guidelines of the AST IDCOP review vaccination of solid organ transplant candidates and recipients. General principles of vaccination as well as the use of specific vaccines in this population are discussed. Vaccination should be reviewed in the pre-transplant setting and appropriate vaccines updated. Read More

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http://dx.doi.org/10.1111/ctr.13563DOI Listing

Varicella complicated by necrotizing soft tissue infection in childhood: an argument for systematic childhood varicella vaccination in France?

Eur J Dermatol 2019 Feb;29(1):91-93

CHU of Clermont-Ferrand, Estaing Hospital, Oral and Maxillofacial Department, 1, place Lucie-Aubrac, 63003 Clermont-Ferrand cedex 1, France, University of Auvergne, Faculty of Medicine, 28, place Henri-Dunant, BP 38, 63001 Clermont-Ferrand cedex 1, France, University of Lille Nord de France, UMR Inserm U1008, Controlled Drug Delivery Systems and Biomaterials, 59000 Lille, France.

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http://dx.doi.org/10.1684/ejd.2018.3462DOI Listing
February 2019

The 2017 human monkeypox outbreak in Nigeria-Report of outbreak experience and response in the Niger Delta University Teaching Hospital, Bayelsa State, Nigeria.

PLoS One 2019 17;14(4):e0214229. Epub 2019 Apr 17.

Nigerian Centre for Disease Control, Abuja, Nigeria.

Background: In September 2017, Nigeria experienced a large outbreak of human monkeypox (HMPX). In this study, we report the outbreak experience and response in the Niger Delta University Teaching Hospital (NDUTH), Bayelsa state, where the index case and majority of suspected cases were reported.

Methods: In a cross-sectional study between September 25th and 31st December 2017, we reviewed the clinical and laboratory characteristics of all suspected and confirmed cases of HMPX seen at the NDUTH and appraised the plans, activities and challenges of the hospital in response to the outbreak based on documented observations of the hospital's infection control committee (IPC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214229PLOS
April 2019
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Today's vaccination policies in Italy: The National Plan for Vaccine Prevention 2017-2019 and the Law 119/2017 on the mandatory vaccinations.

Ann Ig 2019 Mar-Apr;31(2 Supple 1):54-64

Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Italy.

The National Plan for Vaccine Prevention 2017-2019 has expanded the vaccination offer including new vaccines, enlarging the target population and introducing for the first time in Italy a life-course approach to vaccination. A "lifetime immunization schedule" is aimed to reduce the burden and the related costs of vaccine-preventable diseases through effective vaccination programs. However, to counteract the national steady downward trend in the uptake of vaccinations that caused a drop of the vaccination coverage below the 95% threshold to allow herd immunity, it was decided to make 10 vaccinations mandatory by the law 119/2017. Read More

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http://dx.doi.org/10.7416/ai.2019.2277DOI Listing
April 2019
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Epidemiology of viral infections among children undergoing hematopoietic stem cell transplant: Α prospective single- center study.

Transpl Infect Dis 2019 Apr 16:e13095. Epub 2019 Apr 16.

Pediatric Clinic, "P & A Kyriakou" Children's Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece.

Background: Viral infections are a significant cause of morbidity and mortality in pediatric transplant populations. We analyzed the epidemiology of viral infections in pediatric hematopoietic stem cell transplant (HSCT) patients, including their incidence, associated risk factors, and outcome.

Methods: In a prospective study from September 2011 to September 2015 blood, urine and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected, by use of real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1111/tid.13095DOI Listing
April 2019
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Ramsay Hunt Syndrome Associated with True Vocal Cord Palsy- A Case Report.

Iran J Otorhinolaryngol 2019 Mar;31(103):115-118

Departments of Otorhinolaryngology, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Varicella-zoster virus may cause an infectious disease called Ramsay Hunt syndrome. The related symptoms include facial nerve palsy (FNP), otalgia, the vesicular eruptions of the auricle and external auditory canal, less common ocular movement disorder, facial hypoesthesia, myofascial pain, vestibular symptoms, hearing loss, dysphasia, vocal cord paralysis, as well as tongue paralysis due to cranial neuropathies.

Case Report: Herein, we presented the case of a 55-year-old man with left peripheral facial nerve palsy, profound hearing loss, and true vocal cord paralysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449524PMC
March 2019
4 Reads

[Cutaneous Herpesvirus Infection].

Authors:
Daisuke Watanabe

Brain Nerve 2019 Apr;71(4):302-308

Dermatology, Aichi Medical University.

Among human herpes viruses, those known to cause neurological symptoms are the herpes simplex virus (HSV) types 1 and 2 and the varicella-zoster virus (VZV), which remain latent in the dorsal root ganglion. HSV causes herpes labialis, genital herpes, etc. VZV causes varicella during the primary infection, and shingles when reactivated. Read More

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https://webview.isho.jp/journal/detail/abs/10.11477/mf.14162
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http://dx.doi.org/10.11477/mf.1416201266DOI Listing
April 2019
2 Reads

Varicella-Zoster Virus-Induced Hepatitis in a Liver Transplant Recipient: A Case Report.

Transplant Proc 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastroenterology and Organ Transplantation Center, Koc University School of Medicine, Istanbul, Turkey.

Infections after solid organ transplantation are a major cause of mortality and morbidity. Varicella-zoster virus (VZV) infection after solid organ transplantation is rare. Here we present a case presenting with acute hepatitis and shingles after a liver transplantation (LT). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183172
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http://dx.doi.org/10.1016/j.transproceed.2019.01.092DOI Listing
February 2019
2 Reads

Acute truncal ataxia in a healthy adult with varicella zoster virus cerebellitis: A case report and literature review.

J Neurol Sci 2019 May 2;400:186-187. Epub 2019 Apr 2.

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Acute cerebellitis is a well recognized complication of varicella zoster virus (VZV) infection in children. It has been described in adults in the setting of virus reactivation with a preceding herpes zoster rash, but it is exceedingly rare in adults who are not elderly or immunocompromised, particularly in the absence of a rash. To our knowledge, there has been only one reported case of acute cerebellitis in an immunocompetent adult less than age 65 with virological confirmation of acute VZV infection. Read More

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http://dx.doi.org/10.1016/j.jns.2019.04.001DOI Listing
May 2019
1 Read

Chronic-relapsing varicella zoster meningitis - successfully treated with varicella vaccine.

J Infect 2019 Apr 10. Epub 2019 Apr 10.

Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester; Respiratory Sciences, University of Leicester, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.04.009DOI Listing
April 2019
3 Reads

Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe.

Pediatr Blood Cancer 2019 Apr 12:e27752. Epub 2019 Apr 12.

Department of Pediatric Hematology and Oncology, Justus Liebig University Giessen, Giessen, Germany.

Background: Epstein-Barr virus (EBV) is linked to a variety of malignancies; most endemic Burkitt lymphoma (BL) harbor EBV, whereas only a subset of the cases of sporadic BL is EBV positive.

Procedure: We retrospectively determined the herpesvirus seroprevalence at the time of diagnosis in pediatric non-Hodgkin lymphoma (NHL) patients enrolled in NHL-BFM (Berlin-Frankfurt-Muenster) studies. We accessed the seroepidemiological data from 1147 patients that became available during 1990-2007. Read More

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http://dx.doi.org/10.1002/pbc.27752DOI Listing
April 2019
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An ODE-based mixed modelling approach for B- and T-cell dynamics induced by Varicella-Zoster Virus vaccines in adults shows higher T-cell proliferation with Shingrix than with Varilrix.

Vaccine 2019 May 8;37(19):2537-2553. Epub 2019 Apr 8.

Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium; Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium; Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium.

Clinical trials covering the immunogenicity of a vaccine aim to study the longitudinal dynamics of certain immune cells after vaccination. The corresponding immunogenicity datasets are mainly analyzed by the use of statistical (mixed effects) models. This paper proposes the use of mathematical ordinary differential equation (ODE) models, combined with a mixed effects approach. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.075DOI Listing
May 2019
1 Read

Infectious causes of stroke.

Curr Opin Infect Dis 2019 Apr 9. Epub 2019 Apr 9.

Cerebrovascular Center, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: Stroke continuous to be a leading cause of debility in the world. Infections have been associated with stroke, but are not considered as directly causal, and so they are not often included in the traditional stroke workup and management. They are especially important in patients with stroke of undetermined etiology, and in certain patient populations, such as young patients without traditional risk factors, and immunocompromised patients. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000547DOI Listing
April 2019
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Understanding the immunology of the Zostavax shingles vaccine.

Curr Opin Immunol 2019 Apr 7;59:25-30. Epub 2019 Apr 7.

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

Zostavax is a live-attenuated varicella zoster virus (VZV) vaccine recommended for use in adults >50 years of age to prevent shingles. The main risk factor for the development of shingles is age, which correlates with decreasing cell-mediated immunity. These data suggest a predominant role of T cell immunity in controlling VZV latency. Read More

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http://dx.doi.org/10.1016/j.coi.2019.02.005DOI Listing
April 2019
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Risks and risk management in modern multiple sclerosis immunotherapeutic treatment.

Ther Adv Neurol Disord 2019 1;12:1756286419836571. Epub 2019 Apr 1.

Department of Neurology with Institute of Translational Neurology, University of Münster, Building A1, Albert Schweitzer Campus 1, 48149 Münster, Germany.

In recent years, there has been a paradigm shift in the treatment of multiple sclerosis (MS) owing to the approval of a number of new drugs with very distinct mechanisms of action. All approved disease-modifying drugs primarily work directly on the immune system. However, the identification of an 'optimal choice' for individual patients with regard to treatment efficacy, treatment adherence and side-effect profile has become increasingly complex including conceptual as well as practical considerations. Read More

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http://dx.doi.org/10.1177/1756286419836571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444778PMC
April 2019
4 Reads

A step beyond the hygiene hypothesis-immune-mediated classes determined in a population-based study.

BMC Med 2019 Apr 9;17(1):75. Epub 2019 Apr 9.

Department of Psychiatry, Center for Research in Psychiatric Epidemiology and Psychopathology, Lausanne University Hospital, Prilly, Switzerland.

Background: Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Read More

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http://dx.doi.org/10.1186/s12916-019-1311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454751PMC
April 2019
1 Read
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Safety and seropositivity after live attenuated vaccine in adult patients receiving hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2019 Apr 5. Epub 2019 Apr 5.

Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka. Electronic address:

Vaccination against vaccine-preventable diseases (VPDs) is highly recommended for hematopoietic stem cell transplantation (HSCT) recipients by several guidelines; however, the safety and seropositivity after live attenuated vaccines remain unclear in adult HSCT recipients. We analyzed titers of antibodies against measles, rubella, mumps, and varicella zoster virus (VZV) from Japanese adult patients who underwent allogeneic HSCT (allo-HSCT) (n = 74), autologous HSCT (auto-HSCT) (n = 39), or chemotherapy (n = 93). The seropositive rates for measles, rubella, mumps, and VZV in allo-HSCT recipients were 20. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.006DOI Listing
April 2019
1 Read

Post-total knee arthroplasty herpes zoster activation.

BMJ Case Rep 2019 Apr 5;12(4). Epub 2019 Apr 5.

Department of Trauma and Emergency (Anesthesia), All India Institute of Medical Sciences Bhubaneswar, Orissa, India.

Herpes zoster is a clinical manifestation of reactivation of varicella-zoster virus (VZV) that lies dormant in the dorsal root ganglia after a past primary infection. It can be associated with severe pain, a crop of vesicles in typical dermatomal distribution but the neuralgic pain persists long, making the patient uncomfortable and often disturbing patient's sleep. There are cases reported after trauma or post surgeries that are mainly related to organ transplant or malignancy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228639DOI Listing
April 2019
2 Reads

Pericarditis caused by herpes zoster.

J Cardiol Cases 2019 Mar 23;19(3):77-80. Epub 2018 Dec 23.

Department of Cardiovascular Medicine, Tokyo Teishin Hospital, Tokyo, Japan.

A 53-year-old immunocompetent male visited our hospital complaining of chest pain which persisted for 6 h. After detailed examination, the patient was diagnosed with viral pericarditis and treated with aspirin. On day 3 after admission, rash with blisters appeared on the right side of chest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18785409183010
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http://dx.doi.org/10.1016/j.jccase.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429528PMC
March 2019
4 Reads

Varicella gangrenosum in adult: a fatal chickenpox complication.

BMJ Case Rep 2019 Apr 4;12(4). Epub 2019 Apr 4.

Urology, King George's Medical University, Lucknow, Uttar-Pradesh, India.

Varicella gangrenosum is a gangrenous ulceration of varicella lesions involving the skin and soft tissues of the body. The term was coined more than 100 years ago. This occurs due to superimposed bacterial infection. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22636
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http://dx.doi.org/10.1136/bcr-2018-226363DOI Listing
April 2019
6 Reads

Acute ataxia in paediatric emergency departments: a multicentre Italian study.

Arch Dis Child 2019 Apr 4. Epub 2019 Apr 4.

Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Objectives: To evaluate the causes and management of acute ataxia (AA) in the paediatric emergency setting and to identify clinical features predictive of an underlying clinically urgent neurological pathology (CUNP).

Study Design: This is a retrospective medical chart analysis of children (1-18 years) attending to 11 paediatric emergency departments (EDs) for AA in an 8-year period. A logistic regression model was applied to identify clinical risk factors for CUNP. Read More

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http://adc.bmj.com/lookup/doi/10.1136/archdischild-2018-3154
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http://dx.doi.org/10.1136/archdischild-2018-315487DOI Listing
April 2019
13 Reads

Zoster vaccination in older adults: efficacy and public health implications.

J Gerontol A Biol Sci Med Sci 2019 Apr 4. Epub 2019 Apr 4.

Health Sciences North Research Institute, Sudbury, ON, Canada.

Shingles and its most common disabling complication, post-herpetic neuralgia (PHN), represents a serious public health challenge in the older population. The decline in the T-cell-mediated immune response to Varicella Zoster Virus after age 50 is clearly associated with increased risk of viral reactivation, causing an acutely painful zoster rash which may have a severe prodrome of dermatomal pain and persist as seriously debilitating PHN well beyond the resolution of the rash. However, new vaccines and adjuvants are being developed and trialed, and are now more effective in preventing shingles and the sequelae of PHN. Read More

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http://dx.doi.org/10.1093/gerona/glz085DOI Listing

Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction.

BMC Ophthalmol 2019 Apr 3;19(1):87. Epub 2019 Apr 3.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist, Kaohsiung, 833, Taiwan.

Background: To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan.

Methods: A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Read More

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http://dx.doi.org/10.1186/s12886-019-1093-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448235PMC
April 2019
2 Reads

Intravenous Immunoglobulin: A Good Choice for Acute Cerebellar Ataxia Associated with Varicella.

J Pediatr Neurosci 2018 Oct-Dec;13(4):512-513

Department of Radiology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.

Postinfectious cerebellar ataxia is the most common cause of acute ataxia in childhood. The most frequently associated viral agent is varicella. Acute cerebellar ataxia is considered benign, and its symptoms usually diminish within several weeks. Read More

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http://dx.doi.org/10.4103/JPN.JPN_79_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413601PMC
April 2019
2 Reads

Bullous varicella in an immunocompetent infant.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Dermatology, CHU IBN Sina de Rabat Morocco, Rabat, Morocco.

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http://dx.doi.org/10.1136/bcr-2018-229025DOI Listing
March 2019
1 Read

Multi-organ involvement secondary to varicella zoster virus, herpes simplex virus and cytomegalovirus in an immunocompromised patient.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Division of Pulmonaryand Critical Care Medicine, University of South Florida, Tampa, Florida, USA.

The use of immunosuppressing agents can act as a catalyst for viral reactivation, promoting systemic infection with organ involvement. Current literature remains sparse on this topic but does provide individual case reports involving single viruses. We present the case of an immunocompromised patient with skin lesions, pancreatitis, colitis and hepatitis. Read More

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http://dx.doi.org/10.1136/bcr-2018-228150DOI Listing
March 2019
3 Reads

Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials.

Vaccine 2019 Apr 29;37(18):2482-2493. Epub 2019 Mar 29.

GSK, Wavre, Belgium. Electronic address:

Background: The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.

Methods: Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.043DOI Listing
April 2019
3 Reads

Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses-A systematic review.

Complement Ther Med 2019 Apr 22;43:81-84. Epub 2019 Jan 22.

Ortenau Klinikum Offenburg und Gengenbach, Ebertplatz 12, 77654, Offenburg, Germany. Electronic address:

Objectives: To assess the value of bee products with respect to antiviral efficacy against herpes viruses.

Design: A systematic review was done using the JUSTfind System of the Justus-Liebig-University Gießen and Scopus.

Results: Three trials on honey and 6 trials on propolis were conducted. Read More

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http://dx.doi.org/10.1016/j.ctim.2019.01.014DOI Listing
April 2019
1 Read

Varicella Zoster Virus and Neurological Complications.

J Assoc Physicians India 2019 Jan;67(1):99

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January 2019
2 Reads

Invasive Group A Streptococcus Infection in Children in Southern Israel Before and After the Introduction of Varicella Vaccine.

J Pediatric Infect Dis Soc 2019 Mar 31. Epub 2019 Mar 31.

Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel.

The annual rates of group A Streptococcus bacteremia per 100 000 children in southern Israel declined after introduction of the varicella vaccine to the national immunization program, from 2.43 (95% confidence interval, 1.73-3. Read More

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http://dx.doi.org/10.1093/jpids/piz013DOI Listing

Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia.

Haematologica 2019 Mar 28. Epub 2019 Mar 28.

Justus Liebig University, Giessen, Germany;

Platelet autoantibody-induced platelet clearance represents a major pathomechanism in immune thrombocytopenia. Evidence for clinical differences between anti-glycoprotein IIb/IIIa and anti-glycoprotein Ib/IX mediated immune thrombocytopenia is currently accumulating. Glycoprotein V is a well characterized target antigen in Varicella-associated and drug-induced thrombocytopenia. Read More

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http://dx.doi.org/10.3324/haematol.2018.211086DOI Listing
March 2019
1 Read

School, child care and camp exclusion policies for chickenpox: A rational approach.

Paediatr Child Health 2018 Sep 16;23(6):420-427. Epub 2018 Aug 16.

Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario.

Widespread varicella vaccination in Canada since 2007 has changed the epidemiology of chickenpox, with a significant decline in varicella-related hospitalizations. However, there will always be a varicella-susceptible population because of immune-compromising treatments or conditions and/or parental vaccine refusal. This document updates and replaces a 1999 statement by the Canadian Paediatric Society. Read More

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http://dx.doi.org/10.1093/pch/pxy096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234420PMC
September 2018
1 Read

[Varicella is not always benign].

Pan Afr Med J 2018 13;31:30. Epub 2018 Sep 13.

Service de Pédiatrie, Centre Hospitalier Universitaire Mohamed VI, Faculté de Médecine et de Pharmacie, Université Mohammed Premier, Oujda, Maroc.

Varicella is a rash illness caused by the varicella-zoster virus. It mainly affects children with usually a benign outcome. However, several complications of variable severity can be observed including bacterial infectious complications and neurological complications. Read More

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http://www.panafrican-med-journal.com/content/article/31/30/
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http://dx.doi.org/10.11604/pamj.2018.31.30.16730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430838PMC
April 2019
3 Reads

A Case of Varicella-zoster Virus Related Pulmonary Granulomas in Which Varicella-zoster Virus DNA was Demonstrated in a Thoracoscopic Lung Biopsy Specimen.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Japan.

A 43-year-old man with malignant lymphoma who had been treated with the C-MOPP regimen was admitted to our hospital with skin eruption. He was diagnosed to have varicella, and treatment with acyclovir and immune globulin was started. Chest computed tomography revealed multiple nodules in the both lung fields. Read More

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http://dx.doi.org/10.2169/internalmedicine.2021-18DOI Listing
March 2019
1 Read

Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner.

J Virol 2019 Mar 27. Epub 2019 Mar 27.

Department of Microbiology and Immunology, and Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932

The major immediate-early IE62 protein of varicella-zoster virus (VZV) is delivered to newly infected cell nuclei, where it initiates VZV replication by transactivating viral immediate-early (IE), early (E), and late (L) genes. Interferon gamma (IFN-γ) is a potent cytokine produced following primary VZV infection. Furthermore, VZV reactivation correlates with a decline in IFN-γ-producing immune cells. Read More

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http://dx.doi.org/10.1128/JVI.00257-19DOI Listing
March 2019
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Herpes zoster vaccination efficacy in the long-term care facility population: a qualitative systematic review.

Curr Med Res Opin 2019 Mar 27. Epub 2019 Mar 27.

e Baycrest Health Sciences , Toronto , Canada.

Background: The Varicella Zoster virus (VZV) can reactivate later in life as Herpes Zoster infection (HZI), a severe disease resulting in painful complications such as post-herpetic neuralgia (PHN). The Herpes Zoster (HZ) vaccine has been indicated for use among adults 50 years and older for prevention of HZI. Currently, no clinical practice guideline or funding exists specifically for HZ immunization in long-term care facilities (LTCF) for adults age >60 years. Read More

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https://www.tandfonline.com/doi/full/10.1080/03007995.2019.1
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http://dx.doi.org/10.1080/03007995.2019.1600482DOI Listing
March 2019
7 Reads

[Seroepidemiology of varicella among the healthy population aged 1-19 years in Harbin, China].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Mar;21(3):203-207

Division of Immunization Program, Harbin Center for Disease Control and Prevention, Harbin 150056, China.

Objective: To investigate the level of IgG antibody to varicella in the healthy population aged 1-19 years in Harbin, China.

Methods: Random sampling was performed to select 1 203 healthy individuals aged 1-19 years in Harbin. According to age, they were divided into ≥1 years group (n=240), ≥4 years group (n=396), ≥7 years group (n=364) and 14-19 years group (n=203). Read More

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March 2019
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[Epidemiological and clinical features of vaccine-preventable diseases in vaccine era].

Authors:
Qi-Ru Su Kai-Hu Yao

Zhongguo Dang Dai Er Ke Za Zhi 2019 Mar;21(3):195-198

Department of Pediatric Research Institute, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, China.

In countries and regions with high vaccination coverage, several vaccine-preventable diseases have been resurged in recent years, such as measles, varicella, pertussis and mumps. Some studies have found that the clinical manifestation and epidemiological characteristics of these diseases were different from those in pre-vaccine era. This article reviewed the clinical and epidemiological features of vaccine-preventable diseases before and after wide immunization implementation, focusing on the situation in China, in order to attract the attention of clinicians, raise awareness, strengthen prevention and control, and promote in-depth research for these diseases. Read More

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March 2019
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An Association Between Herpes Zoster Vaccination and Stroke Reduction Among Elderly Individuals.

Mil Med 2019 Mar;184(Supplement_1):126-132

Defense Health Agency-Immunization Healthcare Branch Regional Office, Building 1-2532 Armistead St, Fort Bragg, NC.

Herpes zoster (HZ, shingles) affects individuals (60+ years) by reactivation of varicella virus from primary infection. Approximately one-third of the general population will develop HZ and are at increased risk of stroke. Our objective was describing possible associations between self-reported HZ vaccination and stroke with the Centers for Disease Control and Prevention's Behavioral Risk Factors Surveillance System, a cross-sectional nationwide telephone survey. Read More

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https://academic.oup.com/milmed/article/184/Supplement_1/126
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http://dx.doi.org/10.1093/milmed/usy343DOI Listing
March 2019
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Risk of herpes zoster with IL-17 inhibitor therapy for psoriasis and other inflammatory conditions.

J Dermatolog Treat 2019 Mar 22:1-7. Epub 2019 Mar 22.

d Dermatology Research and Education Foundation , Irvine , CA , USA.

Background: Psoriasis is a chronic inflammatory skin disease that has been associated with a significantly higher risk of herpes zoster (HZ). Several newer biologics such as secukinumab, ixekizumab, and brodalumab inhibit IL-17 and have been highly effective for treatment of psoriasis. However, adverse events related to the immunosuppressive properties of these biologics have been observed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1597246DOI Listing
March 2019
2 Reads

Simultaneous parotitis and ipsilateral herpes zoster ophthalmicus: coincidence?

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Family Medicine, Ascension Providence Hospital, Novi, Michigan, USA.

A 43-year-old previously healthy man presented to the primary care clinic with concurrent ipsilateral viral parotitis and herpes zoster ophthalmicus. The patient experienced painful swelling below the right ear as well as painful vesicles on the right forehead, eyelid and cheek in the V1 dermatomal region. There were no lesions in the oral cavity or nose. Read More

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http://dx.doi.org/10.1136/bcr-2018-228897DOI Listing
March 2019
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Prevalence and etiology of molar-incisor hypomineralization (MIH) in the city of Istanbul.

J Dent Sci 2018 Dec 11;13(4):318-328. Epub 2018 Jun 11.

Istanbul University, Faculty of Dentistry, Department of Pedodontics, Istanbul, Turkey.

Background/purpose: Molar-Incisor-Hypomineralisation (MIH) is the term used to depict a condition in which one or more of the permanent molar teeth and usually no less than one incisor tooth is hypomineralised and the prevalence rates vary from 2.4 to 40.2%. Read More

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http://dx.doi.org/10.1016/j.jds.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388839PMC
December 2018
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Human herpesvirus infections and dementia or mild cognitive impairment: a systematic review and meta-analysis.

Sci Rep 2019 Mar 18;9(1):4743. Epub 2019 Mar 18.

Faculty of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.

Interest is growing in the role of infectious agents in the pathogenesis of dementia, but current evidence is limited. We conducted a systematic review and meta-analysis to investigate the effect of any of eight human herpesviruses on development of dementia or mild cognitive impairment (MCI). We searched the Cochrane Library, Embase, Global Health, Medline, PsycINFO, Scopus, Web of Science, clinical trials registers and grey literature sources from inception to December 2017 for observational studies with cohort, case control or self-controlled designs, or randomised controlled trials of interventions against herpesviruses. Read More

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http://dx.doi.org/10.1038/s41598-019-41218-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426940PMC
March 2019
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Herpes zoster onset 9 years after first varicella zoster vaccination in a 11 year old child - a case report.

Curr Pediatr Rev 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, University General Hospital of Patras. Greece.

Background: Herpes zoster (HZ) tends to affect the elderly population and immunocompromised younger patients. However, HZ cases in healthy children have also been reported.

Objective: This paper is a reminder to physicians, that Herpes Zoster can still present in children, even in the era after the development of the varicella vaccine and its introduction in the national immunization programs globally. Read More

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http://dx.doi.org/10.2174/1573396315666190318163927DOI Listing
March 2019
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