17,666 results match your criteria Pediatrics Chicken Pox or Varicella


Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus.

J Neuroinflammation 2019 Feb 18;16(1):42. Epub 2019 Feb 18.

Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Varicella-zoster virus (VZV) is a common viral agent causing central nervous system (CNS) infections including encephalitis, meningitis, and Ramsay Hunt syndrome. Neurological complications occur frequently despite antiviral treatment. Matrix metalloproteinases (MMPs) and cytokines are involved in the neuroinflammatory response during CNS infection. Read More

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http://dx.doi.org/10.1186/s12974-019-1428-1DOI Listing
February 2019

Epidemiological and clinical characteristics and the approach to infant chickenpox in primary care.

Eur J Pediatr 2019 Feb 14. Epub 2019 Feb 14.

Primary health care Miralbueno, Servicio Aragonés de Salud, Zaragoza, Spain.

Chickenpox is not common in the first year of life (infant varicella) and there is a lack of data on its presentation, especially in primary care. A year-long observational study (July 2015-2016) carried out by a research network of primary care pediatricians throughout Spain.Two hundred and sixty-four pediatricians gathered data from 358 cases of clinically diagnosed chickenpox in infants. Read More

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http://dx.doi.org/10.1007/s00431-019-03332-9DOI Listing
February 2019

Corrigendum: Aromatase Derived Estradiol Within the Thalamus Modulates Pain Induced by Varicella Zoster Virus.

Front Integr Neurosci 2018 31;12:66. Epub 2019 Jan 31.

Department of Ophthalmology and of Molecular Microbiology and Genetics, Eye and Ear Foundation, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

[This corrects the article DOI: 10.3389/fnint.2018. Read More

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http://dx.doi.org/10.3389/fnint.2018.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366361PMC
January 2019

Association between statin use and herpes zoster: systematic review and meta-analysis.

BMJ Open 2019 Feb 13;9(2):e022897. Epub 2019 Feb 13.

Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: Statins are commonly prescribed worldwide. In addition to being potent lipid-lowering agents, statins have immunomodulating properties that may increase the risk of varicella zoster virus reactivation. This adverse effect may have substantial public health implications. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022897DOI Listing
February 2019

Long-term protection against varicella with two-dose combination measles-mumps-rubella-varicella vaccine.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

National Centre for Immunisation Research and Surveillance, Westmead, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30797-7DOI Listing
February 2019

Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

University of Defence, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic.

Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella.

Methods: This was a phase 3b follow-up of an observer-blinded, randomised, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183071
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http://dx.doi.org/10.1016/S1473-3099(18)30716-3DOI Listing
February 2019
3 Reads

Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants.

Vaccine 2019 Feb 11. Epub 2019 Feb 11.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed To Be University), Pune, India. Electronic address:

Background: Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193011
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http://dx.doi.org/10.1016/j.vaccine.2019.01.043DOI Listing
February 2019
1 Read

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.

Eur Neurol 2019 Feb 14;80(5-6):283-288. Epub 2019 Feb 14.

Medical School of Chinese PLA, Beijing, China.

Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population.

Materials And Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Read More

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http://dx.doi.org/10.1159/000497319DOI Listing
February 2019

Herpes Zoster-induced Progressive Heart Block: A Case Report.

Cureus 2018 Dec 3;10(12):e3674. Epub 2018 Dec 3.

Cardiology, Aventura Hospital and Medical Center, Aventura, USA.

Varicella-zoster virus (VZV) can produce painful, cutaneous lesions in human beings. Reactivation of this neurotropic virus leads to herpes zoster or shingles: a painful, unilateral, vesicular eruption in a restricted dermatomal distribution. Rarely, reactivation of this virus can lead to cardiac complications, such as myocarditis and even conduction abnormalities. Read More

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http://dx.doi.org/10.7759/cureus.3674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367108PMC
December 2018
1 Read

Infectious complications and NK cell depletion following daratumumab treatment of Multiple Myeloma.

PLoS One 2019 13;14(2):e0211927. Epub 2019 Feb 13.

Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Treatment with Daratumumab (Dara), a monoclonal anti-CD38 antibody of IgG1 subtype, is effective in patients with multiple myeloma (MM). However, Dara also impairs the cellular immunity, which in turn may lead to higher susceptibility to infections. The exact link between immune impairment and infectious complications is unclear. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211927PLOS
February 2019
1 Read

Effectiveness of acyclovir prophylaxis against varicella zoster virus disease after allogeneic hematopoietic cell transplantation: A systematic review and meta-analysis.

Transpl Infect Dis 2019 Feb 13:e13061. Epub 2019 Feb 13.

Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan, 236-0004.

Background: Varicella zoster virus (VZV) disease is a common complication after hematopoietic cell transplantation (HCT). The mortality rate for disseminated VZV infection is 34%. Acyclovir has been used for the prophylaxis of VZV disease after HCT, but the effectiveness of prophylaxis is controversial. Read More

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http://dx.doi.org/10.1111/tid.13061DOI Listing
February 2019
1 Read

Fatal disseminated visceral Varicella Zoster Virus infection in a renal transplant recipient.

Transpl Infect Dis 2019 Feb 12:e13062. Epub 2019 Feb 12.

Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia.

We report a case of fatal disseminated varicella zoster virus (VZV) with delayed-onset rash in a 66-year-old female more than two years following uncomplicated deceased donor renal transplantation. Whilst on a stable regimen of maintenance immunosuppression, the patient presented with chest and abdominal pain with concomitant hepatitis and pancreatitis. After pursuing multiple other potential causes of her symptoms, the correct diagnosis of VZV was only suspected after the development of a widespread vesicular rash - 11 days after her initial symptoms. Read More

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http://dx.doi.org/10.1111/tid.13062DOI Listing
February 2019

Timeliness and completeness of routine childhood vaccinations in young children residing in a district with recurrent vaccine-preventable disease outbreaks, Jerusalem, Israel.

Euro Surveill 2019 Feb;24(6)

Chief Scientist, Ministry of Health, Jerusalem, Israel.

BackgroundChildhood vaccination schedules recommend vaccine doses at predefined ages.AimWe evaluated vaccination completeness and timeliness in Jerusalem, a district with recurrent vaccine-preventable disease outbreaks.MethodsVaccination coverage was monitored by the up-to-date method (vaccination completeness at age 2 years). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1800004DOI Listing
February 2019
1 Read

Incidence and risk factors for herpes zoster after adult liver transplantation.

Ann Surg Treat Res 2019 Feb 30;96(2):95-99. Epub 2018 Jan 30.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus, which occurs frequently in liver transplant recipients with impaired cellular immunity. The purpose of this study was to evaluate the incidence and risk factors for HZ after adult liver transplantation (LT).

Methods: In our institution, 993 patients underwent adult LT from January 1997 to December 2013. Read More

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http://dx.doi.org/10.4174/astr.2019.96.2.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358591PMC
February 2019

Symptomatic improvement using everolimus in infants with cardiac rhabdomyoma.

Ann Pediatr Cardiol 2019 Jan-Apr;12(1):45-48

Department of Pediatric Cardiology, Care Hospital, Hyderabad, Telangana, India.

Background: Cardiac rhabdomyoma (CR) often shows spontaneous regression and needs close follow-up. These tumors may be associated with tuberous sclerosis complex (TSC), caused by the disinhibition of m-TOR protein.

Objective: The aim of the study is to observe the efficacy of everolimus in infants with significant CR. Read More

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http://dx.doi.org/10.4103/apc.APC_79_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343372PMC
February 2019
1 Read

Herpes Zoster in Pregnancy.

J Midwifery Womens Health 2019 Feb 10. Epub 2019 Feb 10.

Vanderbilt University School of Nursing, Nashville, Tennessee.

Herpes zoster (shingles) is the reactivation of dormant varicella zoster virus in individuals who previously experienced varicella infection or vaccination. Herpes zoster can occur in pregnancy, although it is rare. This case report describes the clinical presentation and diagnosis of herpes zoster and reviews current recommendations for treatment. Read More

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http://dx.doi.org/10.1111/jmwh.12953DOI Listing
February 2019
1 Read

Safety and immunogenicity of a varicella vaccine without human serum albumin (HSA) versus a HSA-containing formulation administered in the second year of life: a phase III, double-blind, randomized study.

BMC Pediatr 2019 Feb 7;19(1):50. Epub 2019 Feb 7.

GSK, Avenue Fleming 20, B-1300, Wavre, Belgium.

Background: A new formulation of the live-attenuated varicella vaccine Varilrix (GSK) produced without human serum albumin (HSA) was developed to minimize a theoretical risk of transmission of infectious diseases. A previous study showed that the vaccine was immunologically non-inferior to the HSA-containing vaccine and well-tolerated in toddlers; low-grade fever was numerically higher in children receiving the vaccine without HSA, but the study lacked power to conclude on this difference.

Methods: In this phase III, double-blind, multi-center study, healthy 12-23-month-olds were randomized (1:1) to receive two doses of the varicella vaccine without (Var-HSA group) or with HSA (Var + HSA group) at days 0 and 42. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1425-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366055PMC
February 2019
13 Reads

A case report of severe recurrent varicella in an ankylosing spondylitis patient treated with adalimumab - a new side effect after 15 years of usage.

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367735PMC
February 2019
2 Reads

Comparison of the whole genome sequence of an Oka varicella vaccine from China with other Oka vaccine strains reveals sites putatively critical for vaccine efficacy.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention), WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, People's Republic of China.

Varicella-Zoster Virus (VZV) infection results in varicella mostly in children. Reactivation of the virus causes Herpes Zoster (HZ) mostly in adults. A live attenuated vaccine (vOka-Biken hereafter) was originally derived from the parental strain pOka. Read More

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http://dx.doi.org/10.1128/JVI.02281-18DOI Listing
February 2019
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The impact of childhood varicella vaccination on the incidence of herpes zoster in the general population: modelling the effect of exogenous and endogenous varicella-zoster virus immunity boosting.

BMC Infect Dis 2019 Feb 6;19(1):126. Epub 2019 Feb 6.

Department of Experimental Virology, University Hospital Jena, Jena, Germany.

Background: A controversy exists about the potential effect of childhood varicella vaccination on Herpes Zoster (HZ) incidence. Mathematical models projected temporary HZ incidence increase after vaccine introduction that was not confirmed by real-world evidence. These models assume that absence of contacts with infected children would prevent exogenous boosting of Varicella-Zoster-Virus (VZV) immunity and they do not include an endogenous VZV immunity-boosting mechanism following asymptomatic VZV reactivation. Read More

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http://dx.doi.org/10.1186/s12879-019-3759-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366068PMC
February 2019
2 Reads

Paediatric Active Enhanced Disease Surveillance (PAEDS) annual report 2016: Prospective hospital-based surveillance for serious paediatric conditions

Commun Dis Intell (2018) 2019 Feb 1;43. Epub 2019 Feb 1.

Director, National Centre for Immunisation Research and Surveillance, Kids Research Institute, The Children’s Hospital at Westmead, New South Wales

Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS data is used to better understand these conditions, inform policy and practice under the National Immunisation Program, and enable rapid public health responses for certain conditions of public health importance. PAEDS enhances data available from other Australian surveillance systems by providing prospective, detailed clinical and laboratory information on children with selected conditions. Read More

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February 2019

Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.

J Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Centre for Individualized Infection Medicine, Hannover, Germany.

Background: The tryptophan-kynurenine-NAD+ pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in CNS infections would improve our understanding of pathophysiology and end-organ damage, and, furthermore, open doors to its evaluation as a source of diagnostic and/or prognostic biomarkers.

Methods: We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 220 cerebrospinal fluid samples from patients with bacterial and viral (herpes simplex, varicella zoster, enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (anti-NMDA-R encephalitis, multiple sclerosis), and noninflamed controls (Bell's palsy, normal pressure hydrocephalus, Tourette syndrome). Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz048DOI Listing
February 2019
7 Reads

Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy.

Mayo Clin Proc 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ. Electronic address:

Postherpetic neuralgia (PHN) is the most common complication of varicella zoster virus (VZV) reactivation and a cause of considerable physical and psychosocial morbidity. No known treatment effectively prevents the development of PHN in patients with VZV reactivation. In this study, our objective was to evaluate the efficacy of premedication with gabapentin for reducing the risk of PHN in patients with diabetic and nondiabetic neuropathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00256196183088
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http://dx.doi.org/10.1016/j.mayocp.2018.11.004DOI Listing
February 2019
6 Reads

Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies.

Arch Soc Esp Oftalmol 2019 Feb 1. Epub 2019 Feb 1.

Departamento de Oftalmología, Hospital Ramón y Cajal, Madrid, España.

Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. This leads to epithelial defects, ulceration and, eventually, perforation. Both herpes simplex and varicella zoster keratitis are reported to be the main causes of NK. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.01.002DOI Listing
February 2019
1 Read

Hospital Onset Varicella Central Nervous System Vasculitis in a Patient with HIV Infection.

AIDS Res Hum Retroviruses 2019 Feb 4. Epub 2019 Feb 4.

4 Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1089/aid.2018.0262DOI Listing
February 2019

Identification of the Epstein Barr Virus portal.

Virology 2019 Jan 10;529:152-159. Epub 2019 Jan 10.

Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA.

Little is known about Epstein Barr Virus (EBV) proteins that participate in viral DNA cleavage and packaging. Genes encoding potential terminase subunit and portal protein homologs include BGRF1/BDRF1, BALF3, BFRF1A and BBRF1 respectively. EBV mutants with deletions in one or more of these genes were impaired for DNA packaging (Pavlova et al. Read More

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http://dx.doi.org/10.1016/j.virol.2019.01.003DOI Listing
January 2019
1 Read

Rethinking the causes of pain in herpes zoster and postherpetic neuralgia: the ectopic pacemaker hypothesis.

Authors:
Marshall Devor

Pain Rep 2018 Nov 7;3(6):e702. Epub 2018 Nov 7.

Department of Cell and Developmental Biology, Institute of Life Sciences, and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.

Introduction: Pain in herpes zoster (HZ) and postherpetic neuralgia (PHN) is traditionally explained in terms of 2 processes: irritable nociceptors in the rash-inflamed skin and, later, deafferentation due to destruction of sensory neurons in one virally infected dorsal root ganglion.

Objectives And Methods: Consideration of the evidence supporting this explanation in light of contemporary understanding of the pain system finds it wanting. An alternative hypothesis is proposed as a replacement. Read More

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http://dx.doi.org/10.1097/PR9.0000000000000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344138PMC
November 2018
1 Read

Reliability and accuracy of smartphones for paediatric infectious disease consultations for children with rash in the paediatric emergency department.

BMC Pediatr 2019 Jan 31;19(1):40. Epub 2019 Jan 31.

Department of Pediatric Emergency Department, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Objective: Smartphones and associated messaging applications have become the most common means of communication among health care workers and the general population. The aim of this study was to evaluate the reliability and accuracy of smartphones for the diagnosis of rash in children admitted to emergency departments during the night shift.

Methods: The images of the children who were admitted to the paediatric emergency department with rash were included in this study, and at least two images taken with smartphones by residents or paediatric infectious disease fellows were re-directed to the chief consultant of the Paediatric-Infectious Department via smartphone. Read More

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http://dx.doi.org/10.1186/s12887-019-1416-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354364PMC
January 2019
1 Read

Recognition of aerosol transmission of infectious agents: a commentary.

BMC Infect Dis 2019 Jan 31;19(1):101. Epub 2019 Jan 31.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

Although short-range large-droplet transmission is possible for most respiratory infectious agents, deciding on whether the same agent is also airborne has a potentially huge impact on the types (and costs) of infection control interventions that are required.The concept and definition of aerosols is also discussed, as is the concept of large droplet transmission, and airborne transmission which is meant by most authors to be synonymous with aerosol transmission, although some use the term to mean either large droplet or aerosol transmission.However, these terms are often used confusingly when discussing specific infection control interventions for individual pathogens that are accepted to be mostly transmitted by the airborne (aerosol) route (e. Read More

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http://dx.doi.org/10.1186/s12879-019-3707-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357359PMC
January 2019
1 Read

Ramsay Hunt syndrome with pontine lesion: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14260

Department of Neurological Function Examination.

Rationale: The coexistence of Ramsay Hunt syndrome (RHS) and varicella-zoster virus (VZV) encephalitis is rare. A patient who developed RHS after being infected with VZV, along with a pontine lesion, is reported in the present study.

Patient Concerns: A 41-year-old male patient presented with his mouth askew for 7 days, and dizziness, accompanied by hearing loss for 3 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000014260DOI Listing
February 2019
1 Read
5.723 Impact Factor

CLINICAL-PATHOGENETICAL ROLE OF TOLL-LIKE RECEPTOR 2 (RS 5743708) AND INTERLEUKIN-10 (RS 1800896) GENES POLYMORPHISM IN THE COURSE OF HERPES ZOSTER IN ADULTS.

Georgian Med News 2018 Dec(285):81-86

Zaporizhzhya State Medical University, Ukraine.

The study included 50 adult patients with shingles by which analyzed the clinical course of the disease depending on the gene polymorphism of interleukin-10 (rs 1800896) and toll-like receptor 2 (rs 5743708). According to the results of our study, it was established that genotype AA of gene Toll-like receptor 2 was associated with a high risk of Varicella-Zoster virus reactivation and manifestation of herpes zoster, moderate course. Analysis of the IL-10 gene polymorphism showed that genotype TT was associated with a risk of the development severe complicated course of shingles. Read More

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December 2018
2 Reads

Central nervous system varicella zoster vasculopathy in an immunocompromised patient.

IDCases 2019 29;15:e00483. Epub 2018 Dec 29.

Infectious Diseases Department, Centro Hospitalar Universitário São João, Oporto, Portugal.

Central nervous system (CNS) vasculopathy associated with Varicella Zoster Virus (VZV) infection, usually manifesting as stroke due to ischemic lesions by involvement of small arteries, is frequently misdiagnosed. Immunocompromised patients have a particularly higher risk of severe disease and also CNS involvement during or following VZV presentations. We report a case of an 84-year-old man, with myelodysplastic syndrome, who presented with herpes zoster ophthalmicus complicated with left periocular cellulitis and an abnormal neurological exam. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348231PMC
December 2018
1 Read

Anti-NMDAR encephalitis with concomitant varicella zoster virus detection and nonteratomatous malignancy.

Neurol Neuroimmunol Neuroinflamm 2019 Mar 9;6(2):e537. Epub 2018 Jan 9.

Department of Internal Medicine (P.A.P., K.M.), Department of Neurology (J.J., T.G., J.S.K.), Department of Anesthesia (W.C.T.), and Department of Pulmonary, Critical Care, and Sleep Medicine (P.P.), Baylor College of Medicine; and National School of Tropical Medicine (J.E.W.), Baylor College of Medicine, Houston, TX.

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http://dx.doi.org/10.1212/NXI.0000000000000537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340333PMC
March 2019
1 Read

Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study.

Bone Marrow Transplant 2019 Jan 29. Epub 2019 Jan 29.

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. Read More

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http://dx.doi.org/10.1038/s41409-019-0457-9DOI Listing
January 2019
2 Reads

Herpes zoster presenting as unilateral vasculitis.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Department of Dermatology, Oregon Health and Science University, Portland, Oregon.

Vasculitis can be a primary disorder or a cutaneous manifestation of a viral infection. The present case describes an atypical localized cutaneous varicella-zoster virus infection inducing a small vessel vasculitis in a patient with multisystem sarcoidosis. Additionally, we discuss the differential diagnoses and treatment options. Read More

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November 2018
1 Read

Serological and T Cell Responses After Varicella Zoster Virus Vaccination in HIV-Positive Patients Undergoing Renal Dialysis.

Viral Immunol 2019 Jan 29. Epub 2019 Jan 29.

1 Infectious Diseases Division, Udine Healthcare and University Integrated Trust, Udine, Italy.

Limited data on varicella zoster virus (VZV) vaccine responses are available in HIV-positive adults, especially among those with end-stage renal disease on dialysis or undergoing kidney transplantation (KT). Serological and T cell responses were analyzed using anti-VZV IgG titers, enzyme-linked immunosorbent assay and flow cytometric intracellular cytokine staining (ICS) in two HIV-positive kidney transplant candidates undergoing dialysis and receiving VZV immunization. The results were compared with two HIV-positive and two HIV-negative VZV-seropositive patients (two kidney transplant candidates and two kidney transplant recipients), and with one HIV-negative vaccinee. Read More

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http://dx.doi.org/10.1089/vim.2018.0112DOI Listing
January 2019
1 Read

Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking.

J Gen Virol 2019 Jan 29. Epub 2019 Jan 29.

1​Laboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.

Bovine herpesvirus 1 (BoHV-1)-encoded UL49.5 (a homologue of herpesvirus glycoprotein N) can combine different functions, regulated by complex formation with viral glycoprotein M (gM). We aimed to identify the mechanisms governing the immunomodulatory activity of BoHV-1 UL49. Read More

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http://dx.doi.org/10.1099/jgv.0.001224DOI Listing
January 2019
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Safety of live attenuated varicella-zoster vaccine in patients with underlying illnesses compared with healthy adults: a prospective cohort study.

BMC Infect Dis 2019 Jan 28;19(1):95. Epub 2019 Jan 28.

Kanonji Institute, Research Foundation for Microbial Diseases of Osaka University, 4-1-70, Seto-Cho, Kanonji, Kagawa, 768-0065, Japan.

Background: In Japan, freeze-dried live attenuated varicella-zoster vaccine is available for adults aged ≥50 years to prevent herpes zoster. However, limited evidence has been accumulated regarding vaccine safety for patients with underlying illnesses, who have been considered as the high-risk group for herpes zoster.

Methods: A prospective cohort study of 1200 healthy adults and 300 patients with underlying illnesses such as malignancy, diabetes mellitus, autoimmune diseases, and renal diseases was conducted. Read More

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http://dx.doi.org/10.1186/s12879-019-3719-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350288PMC
January 2019
2 Reads

Current In Vitro Models to Study Varicella Zoster Virus Latency and Reactivation.

Viruses 2019 Jan 26;11(2). Epub 2019 Jan 26.

Institute of Virology, Hannover Medical School, 30625 Hannover, Germany.

Varicella zoster virus (VZV) is a highly prevalent human pathogen that causes varicella (chicken pox) during primary infection and establishes latency in peripheral neurons. Symptomatic reactivation often presents as zoster (shingles), but it has also been linked to life-threatening diseases such as encephalitis, vasculopathy and meningitis. Zoster may be followed by postherpetic neuralgia, neuropathic pain lasting after resolution of the rash. Read More

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http://dx.doi.org/10.3390/v11020103DOI Listing
January 2019
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Hemorrhagic shock resulting from varicella zoster gastritis in a non-immunocompromised patient.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France; Groupe de Recherche Clinique CARMAS, Université Paris-Est Créteil, IMRB, Créteil, France.

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http://dx.doi.org/10.1016/j.ijid.2019.01.042DOI Listing
January 2019
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Seroprevalence of varicella-zoster virus among pregnant women in Fayoum Governorate, Egypt.

J Egypt Public Health Assoc 2019 7;94(1). Epub 2019 Jan 7.

3Obstetric and Gynecological Department, Faculty of Medicine, Fayoum University, Faiyum, Egypt.

Background: Chickenpox infection acquired during pregnancy is a serious condition. There may be congenital malformations and neonatal varicella syndrome with significant morbidity and mortality. Egypt has no routine varicella-zoster vaccination program. Read More

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http://dx.doi.org/10.1186/s42506-018-0002-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325979PMC
January 2019
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Wild banana [Ensete superbum (Roxb.) Cheesman.]: Ethnomedicinal, phytochemical and pharmacological overview.

J Ethnopharmacol 2019 Apr 25;233:218-233. Epub 2019 Jan 25.

National Innovation Foundation-India (Autonomous Body of Department of Science and Technology, Govt. of India), Grambharti, Amarapur, Gandhinagar, Gujarat 382650, India. Electronic address:

Ethnopharmacological Relevance: Ensete superbum (Roxb.) Cheesman. (Family: Musaceae), commonly known as "Wild Banana" is well recorded as popular ethnomedicine for medicinal and nutritional uses by different people and communities native to India, Ethiopia, Thailand, Myanmar and Vietnam. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183297
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http://dx.doi.org/10.1016/j.jep.2018.12.048DOI Listing
April 2019
4 Reads

Antiviral activity spectrum of phenoxazine nucleoside derivatives.

Antiviral Res 2019 Mar 23;163:117-124. Epub 2019 Jan 23.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia. Electronic address:

The phenoxazine scaffold is widely used to stabilize nucleic acid duplexes, as a part of fluorescent probes for the study of nucleic acid structure, recognition, and metabolism, etc. Here we present the synthesis of phenoxazine-based nucleoside derivatives and their antiviral activity against a panel of structurally diverse viruses: enveloped DNA herpesviruses varicella zoster virus (VZV) and human cytomegalovirus, enveloped RNA tick-borne encephalitis virus (TBEV), and non-enveloped RNA enteroviruses. Studied compounds were effective against DNA and RNA viruses reproduction in cell culture. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.01.010DOI Listing
March 2019
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Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin.

BMC Infect Dis 2019 Jan 25;19(1):91. Epub 2019 Jan 25.

GEPAMOL, Centro de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia.

Background: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools.

Methods: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Read More

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http://dx.doi.org/10.1186/s12879-018-3613-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347798PMC
January 2019
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Varicella healthcare resource utilization in middle income countries: a pooled analysis of the multi-country MARVEL study in Latin America & Europe.

Hum Vaccin Immunother 2019 Jan 25. Epub 2019 Jan 25.

j JSS Medical Research , Montreal , Quebec , Canada.

Varicella is a mild and self-limited illness in children, but can result in significant healthcare resource utilization (HCRU). To quantify/contrast varicella-associated HCRU in five middle-income countries (Hungary, Poland, Argentina, Mexico, and Peru) where universal varicella vaccination was unimplemented, charts were retrospectively reviewed among 1-14 year-olds. Data were obtained on management of primary varicella between 2009-2016, including outpatient/inpatient visits, allied healthcare contacts, tests/procedures, and medications. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
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http://dx.doi.org/10.1080/21645515.2018.1559687DOI Listing
January 2019
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Vaccine strain varicella zoster virus transmitted within a family from a child with shingles results in varicella meningitis in an immunocompetent adult.

Intern Med J 2019 Jan;49(1):132-133

Sunshine Coast University Hospital, Sunshine Coast, Queensland, Australia.

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http://dx.doi.org/10.1111/imj.14178DOI Listing
January 2019
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The risk of infections in multiple myeloma before and after the advent of novel agents: a 12-year survey.

Ann Hematol 2019 Mar 24;98(3):713-722. Epub 2019 Jan 24.

Klinik für Innere Medizin II, Abt. Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.

Infections represent a major cause of morbidity and mortality in multiple myeloma and are linked to both therapy- and disease-related factors. Although it has been suggested that the rate of infections increased since the introduction of novel agents, controversies still exist. To better assess the risk factors associated with infections in the era of novel agents, we conducted a large retrospective analysis of 479 myeloma patients treated at Jena University Hospital over a period of 12 years. Read More

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http://dx.doi.org/10.1007/s00277-019-03621-1DOI Listing
March 2019
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Quadruplex real-time PCR for rapid detection of human alphaherpesviruses.

Med Microbiol Immunol 2019 Jan 24. Epub 2019 Jan 24.

Sektion Experimentelle Virologie, Institut für Medizinische Mikrobiologie, Universitätsklinikum Jena, Hans-Knöll-Strasse 2, 07745, Jena, Germany.

Infections with the herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) as well as with the varicella-zoster virus (VZV) may take a serious course. Thus, rapid and reliable detection of these alphaherpesviruses is urgently needed. For this, we established a qualitative quadruplex real-time polymerase chain reaction (PCR) covering HSV-1, HSV-2, VZV and endogenous human glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Read More

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http://dx.doi.org/10.1007/s00430-019-00580-2DOI Listing
January 2019
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Customs officers in relation to viral infections, tuberculosis, psittacosis and environmental health risk.

Exp Ther Med 2019 Feb 10;17(2):1149-1153. Epub 2018 Dec 10.

Department of Virology, School of Medicine, University of Crete, 71110 Heraklion, Greece.

Customs Service is a financial authority responsible for controlling the flow of importation and exportation goods in each country and for collecting the relevant taxes. Customs officers are considered as 'high-demand' and 'high-responsibility' governmental officials, which constitute members of multidisciplinary teams at the local, as well as international level and collaborate with different authorities, including medical officers. Despite limited data in the medical literature, customs officers are considered as a 'high-risk' occupational group for infections and environmental health risk. Read More

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http://dx.doi.org/10.3892/etm.2018.7077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327673PMC
February 2019
2 Reads