2,392 results match your criteria Pediatrics Bronchiolitis


COVID-19 pandemic: Impact caused by school closure and national lockdown on pediatric visits and admissions for viral and non-viral infections, a time series analysis.

Clin Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Assistance Publique-Hôpitaux de Paris, Department of Clinical Microbiology, Necker-Enfants Malades University Hospital, Université de Paris, Paris, France.

A time series analysis of 871,543 pediatric emergency visits revealed that the COVID-19 lockdown and school closure were associated with a significant decrease in infectious diseases disseminated through airborne or fecal-oral transmissions: common cold, gastro-enteritis, bronchiolitis, acute otitis. No change was found for urinary tract infections. Read More

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http://dx.doi.org/10.1093/cid/ciaa710DOI Listing

Intensive Care Unit Utilization After Adoption of a Ward-Based High-Flow Nasal Cannula Protocol.

J Hosp Med 2020 May 21. Epub 2020 May 21.

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Hospitals are increasingly adopting ward-based high-flow nasal cannula (HFNC) protocols that allow HFNC treatment of bronchiolitis outside of the intensive care unit (ICU). Our objective was to determine whether adoption of a ward-based HFNC protocol reduces ICU utilization.

Methods: We examined a retrospective cohort of infants aged 3 to 24 months hospitalized with bronchiolitis at hospitals in the Pediatric Health Information System database. Read More

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http://dx.doi.org/10.12788/jhm.3417DOI Listing

Group-facilitated audit and feedback to improve bronchiolitis care in the emergency department.

CJEM 2020 Jun 2:1-9. Epub 2020 Jun 2.

Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB.

Objective: Despite strong evidence recommending supportive care as the mainstay of management for most infants with bronchiolitis, prior studies show that patients still receive low-value care (e.g., respiratory viral testing, salbutamol, chest radiography). Read More

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http://dx.doi.org/10.1017/cem.2020.374DOI Listing

Reply to correspondence: "Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments".

Allergy 2020 Jun;75(6):1531-1532

Women's and Children's Health Department, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1111/all.14154DOI Listing

RSV neutralizing antibodies at birth predict protection from RSV illness in infants in the first three months of life.

Clin Infect Dis 2020 May 28. Epub 2020 May 28.

Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, USA.

Background: Respiratory syncytial virus (RSV) is a leading cause of viral pneumonia and bronchiolitis during the first six months of life. Placentally-transferred antibodies can prevent severe RSV illness, and maternal immunization may reduce illness in young infants. Identifying protective antibody levels will facilitate the advancement of vaccine candidates and maternal immunization. Read More

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http://dx.doi.org/10.1093/cid/ciaa648DOI Listing

Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.

Pediatr Allergy Immunol 2020 May 27. Epub 2020 May 27.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Bronchiolitis is the leading cause of infant hospitalizations in the U.S. Growing evidence supports the heterogeneity of bronchiolitis. Read More

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http://dx.doi.org/10.1111/pai.13296DOI Listing

CCL5 persists in RSV stocks following sucrose-gradient purification.

J Leukoc Biol 2020 May 25. Epub 2020 May 25.

Departments of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Respiratory syncytial virus (RSV) is associated with bronchiolitis in infancy and the later development of asthma. Research on RSV in vitro requires preparation of a purified RSV stock. The objective for this work was to develop best methods for RSV purification, while monitoring the samples for potential contaminating proinflammatory mediators. Read More

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http://dx.doi.org/10.1002/JLB.4MA0320-621RDOI Listing

Community antibiotic prescribing for children in France from 2015 to 2017: a cross-sectional national study.

J Antimicrob Chemother 2020 May 25. Epub 2020 May 25.

Université de Paris, Epidemiology and Statistics Research Center - CRESS, INSERM, Obstetrical, Perinatal and Pediatric Epidemiology research team, F-75004 Paris, France.

Objectives: To assess recent community antibiotic prescribing for French children and identify areas of potential improvement.

Methods: We analysed 221 768 paediatric (<15 years) visits in a national sample of 680 French GPs and 70 community paediatricians (IQVIA's EPPM database), from March 2015 to February 2017, excluding well-child visits. We calculated antibiotic prescription rates per 100 visits, separately for GPs and paediatricians. Read More

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http://dx.doi.org/10.1093/jac/dkaa162DOI Listing

Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That.

Front Pediatr 2020 5;8:218. Epub 2020 May 5.

Division of Paediatrics and Child Health, Perth Children's Hospital, University of Western Australia, Nedlands, WA, Australia.

The diagnosis and management of infants and children with a significant viral lower respiratory tract illness remains the subject of much debate and little progress. Over the decades various terms for such illnesses have been in and fallen out of fashion or have evolved to mean different things to different clinicians. Terms such as "bronchiolitis," "reactive airways disease," "viral wheeze," and many more are used to describe the same condition and the same term is frequently used to describe illnesses caused by completely different dominant pathologies. Read More

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http://dx.doi.org/10.3389/fped.2020.00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214804PMC

[HYPERTONIC SALINE FOR HOSPITALIZED INFANTS WITH ACUTE BRONCHIOLITIS IN ISRAEL IN 2018].

Harefuah 2020 May;159(5):349-351

Department of Pediatrics, Laniado Medical Center, Netanya, Israel.

Introduction: Inhalations of hypertonic saline is a known therapy for infants diagnosed with acute bronchiolitis. Recent meta-analysis has shown that it can reduce the length of hospitalization and decrease the chances of admission.

Aims: To assess the extent of use of hypertonic saline inhalations in the pediatric wards in Israel in 2018. Read More

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VIRAL ETIOLOGY AND OUTCOME OF SEVERE LOWER RESPIRATORY TRACT INFECTIONS AMONG CRITICALLY ILL CHILDREN ADMITTED TO THE PICU.

Med Intensiva 2020 May 13. Epub 2020 May 13.

Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Pediatrics Istanbul, Turkey.

Objective: To determine the viral etiology of severe lower respiratory tract infections (LRTIs), their clinical significance and prognosis among critically ill children.

Design: A prospective descriptive study was carried out.

Setting: Pediatric Intensive Care Unit (PICU) of Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey. Read More

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http://dx.doi.org/10.1016/j.medin.2020.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218367PMC

Influenza and Respiratory Syncytial Bronchiolitis, Are There Any Differences?

Indian J Pediatr 2020 May 13. Epub 2020 May 13.

Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1007/s12098-020-03334-8DOI Listing

Reply to Korppi and Riikonen: From bronchiolitis to chronic obstructive lung disease; The role of bronchial hyperreactivity.

Pediatr Allergy Immunol 2020 May 8. Epub 2020 May 8.

Department of Pediatrics, Stavanger University Hospital, Stavanger, Norway.

We highly appreciate Korppi and Riikonen's comment to our article regarding trajectories of lung function and bronchial hyperreactivity (BHR) during puberty in children with bronchiolitis in infancy. Read More

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http://dx.doi.org/10.1111/pai.13272DOI Listing
May 2020
3.397 Impact Factor

Offering welcome in the kingdom of the sick: A physician guide to hospitality.

J Eval Clin Pract 2020 May 7. Epub 2020 May 7.

Department of Educational Studies, Faculty of Education, The University of British Columbia, Vancouver, British Columbia, Canada.

Rationale, Aims And Objectives: The onset of acute illness may be accompanied by a profound sense of disorientation for patients. Addressing this vulnerability is a key part of a physician's purview, yet well-intended efforts to do so may be impeded by myriad competing tasks in clinical practice. Resolving this dilemma goes beyond appealing to altruism, as its limitless demands may lead to physician burnout, disillusionment, and a narrowed focus on the biomedical aspects of care in the interest of self-preservation. Read More

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http://dx.doi.org/10.1111/jep.13410DOI Listing

Symptom-based screening tool for asthma syndrome among young children in Uganda.

NPJ Prim Care Respir Med 2020 May 6;30(1):18. Epub 2020 May 6.

The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Under-diagnosis of asthma in 'under-fives' may be alleviated by improved inquiry into disease history. We assessed a questionnaire-based screening tool for asthma among 614 'under-fives' with severe respiratory illness in Uganda. The questionnaire responses were compared to post hoc consensus diagnoses by three pediatricians who were guided by study definitions that were based on medical history, physical examination findings, laboratory and radiological tests, and response to bronchodilators. Read More

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http://dx.doi.org/10.1038/s41533-020-0175-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203121PMC

Primary immunodeficiency disorders in children with Non-Cystic Fibrosis Bronchiectasis.

Eur Ann Allergy Clin Immunol 2020 May 6. Epub 2020 May 6.

Hacettepe University Medical School, Department of Pediatric Immunology, Ankara, Turkey.

Summary: Primary Immunodeficiency diseases(PID) are common in patients with non-cystic fibrosis bronchiectasis(NCFB). Our objective was to determine ratio/types of PID in NCFB. Seventy NCFB patients followed up in a two-year period were enrolled. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.151DOI Listing

Differential asthma odds following respiratory infection in children from three minority populations.

PLoS One 2020 5;15(5):e0231782. Epub 2020 May 5.

Department of Medicine, University of California, San Francisco, CA, United States of America.

Rationale: Severe early-life respiratory illnesses, particularly those caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV), are strongly associated with the development of asthma in children. Puerto Rican children in particular have a strikingly high asthma burden. However, prior studies of the potential associations between early-life respiratory illnesses and asthma in Puerto Rican and other minority populations have been limited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231782PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199930PMC
May 2020
3.234 Impact Factor

Room Costs for Common Pediatric Hospitalizations and Cost-Reducing Quality Initiatives.

Pediatrics 2020 Jun 4;145(6). Epub 2020 May 4.

Department of Pediatrics, Children's Mercy Kansas City and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri.

Background: Improvement initiatives promote safe and efficient care for hospitalized children. However, these may be associated with limited cost savings. In this article, we sought to understand the potential financial benefit yielded by improvement initiatives by describing the inpatient allocation of costs for common pediatric diagnoses. Read More

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http://dx.doi.org/10.1542/peds.2019-2177DOI Listing

Pulmonary function sequelae after respiratory syncytial virus lower respiratory tract infection in children: A systematic review.

Pediatr Pulmonol 2020 May 4. Epub 2020 May 4.

Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) during early childhood may be associated with subsequent pulmonary sequelae, including recurrent wheezing and asthma. We undertook a systematic review to investigate the pulmonary function sequelae following RSV LRTI in the first 3 years of life. The systematic review protocol was registered on PROSPERO (CRD42018087168). Read More

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http://dx.doi.org/10.1002/ppul.24804DOI Listing

Understanding factors that contribute to variations in bronchiolitis management in acute care settings: a qualitative study in Australia and New Zealand using the Theoretical Domains Framework.

BMC Pediatr 2020 May 1;20(1):189. Epub 2020 May 1.

Children's Emergency Department, Starship Children's Hospital, Private Bag 92024, Auckland, 1142, New Zealand.

Background: Bronchiolitis is the most common reason for infants under one year of age to be hospitalised. Despite management being well defined with high quality evidence of no efficacy for salbutamol, adrenaline, glucocorticoids, antibiotics or chest x-rays, substantial variation in practice occurs. Understanding factors that influence practice variation is vital in order to tailor knowledge translation interventions to improve practice. Read More

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http://dx.doi.org/10.1186/s12887-020-02092-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193400PMC

A Durable Relationship: Respiratory Syncytial Virus Bronchiolitis and Asthma past Their Golden Anniversary.

Vaccines (Basel) 2020 Apr 26;8(2). Epub 2020 Apr 26.

Fundación INFANT, Buenos Aires 1406, Argentina.

Numerous preventive strategies against respiratory syncytial virus (RSV) are undergoing late stage evaluation in humans and, in addition to their intended benefit for acute illness, may impact long term consequences of infection in infants. Severe RSV infection has been repeatedly associated in the literature with long term complications, including impaired lung function, recurrent wheezing, and asthma. However, whether RSV lower respiratory tract infection (LRTI) causally affects the odds for developing wheezing and/or asthma during childhood requires further study, and the biological mechanisms underlying this hypothetical progression from viral illness to chronic lung disease are poorly characterized. Read More

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http://dx.doi.org/10.3390/vaccines8020201DOI Listing

The Effects of Furosemide on Oxygenation in Mechanically Ventilated Children with Bronchiolitis.

J Pediatr Intensive Care 2020 Jun 21;9(2):87-91. Epub 2019 Nov 21.

Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.

Fluid balance management, including diuretic administration, may influence outcomes among mechanically ventilated children. We retrospectively compared oxygenation saturation index (OSI) before and after the initial furosemide bolus among 65 mechanically ventilated children. Furosemide was not associated with a significant change in median OSI (6. Read More

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http://dx.doi.org/10.1055/s-0039-3400467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186015PMC

Testing for Common Respiratory Viruses in Children Admitted to Pediatric Intensive Care: Epidemiology and Outcomes.

Pediatr Crit Care Med 2020 Jun;21(6):e333-e341

Pediatric Critical Care Research Group, Child Health Research Center, The University of Queensland, Brisbane, QLD, Australia.

Objectives: Viral infections are common in children, but there is a lack of data on severe viral infections in critically ill children. We investigated testing for viral infections in children requiring PICU admission and describe the epidemiology and outcomes.

Design: Multicenter retrospective study. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002302DOI Listing

Use of Resident-Sensitive Quality Measure Data in Entrustment Decision-Making: A Qualitative Study of Clinical Competency Committee Members at One Pediatric Residency.

Acad Med 2020 Apr 21. Epub 2020 Apr 21.

D.J. Schumacher is associate professor of pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. A. Martini is a clinical research coordinator, Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. B. Sobolewski is associate professor of pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. C. Carraccio is vice president of competency-based assessment, American Board of Pediatrics, Chapel Hill, North Carolina. E. Holmboe is senior vice president for milestones development and evaluation, Accreditation Council for Graduate Medical Education, Chicago, Illinois. J. Busari is associate professor of medical education, Maastricht University, Maastricht, The Netherlands. S. Poynter is professor of pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. C. van der Vleuten is professor of education, Department of Educational Development and Research, Faculty of Health, Medicine, and Life Sciences, and scientific director, School of Health Professions Education, Maastricht University, Maastricht, The Netherlands. L. Lingard is professor and scientist, Department of Medicine, and director, Center for Education Research & Innovation, Schulich School of Medicine and Dentistry at Western University, London, Ontario, Canada.

Purpose: Resident-sensitive quality measures (RSQMs) are quality measures that are likely performed by an individual resident and are important to care quality for a given illness of interest. This study sought to explore how individual clinical competency committee (CCC) members interpret, use, and prioritize RSQMs alongside traditional assessment data when making a summative entrustment decision.

Method: In this constructivist grounded theory study, 19 members of the pediatric residency CCC at Cincinnati Children's Hospital Medical Center were purposively and theoretically sampled between February and July 2019. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003435DOI Listing

Prevalence of Continuous Pulse Oximetry Monitoring in Hospitalized Children With Bronchiolitis Not Requiring Supplemental Oxygen.

JAMA 2020 04;323(15):1467-1477

Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Importance: US national guidelines discourage the use of continuous pulse oximetry monitoring in hospitalized children with bronchiolitis who do not require supplemental oxygen.

Objective: Measure continuous pulse oximetry use in children with bronchiolitis.

Design, Setting, And Participants: A multicenter cross-sectional study was performed in pediatric wards in 56 US and Canadian hospitals in the Pediatric Research in Inpatient Settings Network from December 1, 2018, through March 31, 2019. Read More

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http://dx.doi.org/10.1001/jama.2020.2998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175084PMC
April 2020
35.289 Impact Factor

Overuse of Continuous Pulse Oximetry for Bronchiolitis: The Need for Deimplementation Science.

JAMA 2020 04;323(15):1449-1450

Boston University School of Medicine, Boston Medical Center, Department of Pediatrics, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2020.4359DOI Listing

Respiratory Complications in Children Hospitalized with Respiratory Syncytial Virus Infection.

Adv Exp Med Biol 2020 Apr 21. Epub 2020 Apr 21.

Department of Pediatrics, Medical Center of Postgraduate Medical Education, Warsaw, Poland.

The goal of this study was to define the prevalence of respiratory complications, other than bronchiolitis, such as pneumonia, acute otitis media, and conjunctivitis in children treated in a hospital due to respiratory syncytial virus (RSV) infection, with reference to the plausible risk factors. The study included 111 children, aged up to 22 months (median 3 months). Complications were observed in 68 (61%) children, with 32 (29%) children presenting more than one. Read More

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http://dx.doi.org/10.1007/5584_2020_530DOI Listing

[Predictive factors for failure of continuous positive airway pressure treatment in infants with bronchiolitis].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Apr;22(4):339-345

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

Objective: To study the predictive factors for the failure of continuous positive airway pressure (CPAP) treatment in infants with bronchiolitis.

Methods: A retrospective analysis was performed on the clinical data of 310 hospitalized children (aged 1-12 months) with bronchiolitis treated with CPAP. Their clinical features were compared between the successful treatment group (270 cases) and the failed treatment group (40 cases). Read More

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Association of rhinovirus species with nasopharyngeal metabolome in bronchiolitis infants: A multicenter study.

Allergy 2020 Apr 18. Epub 2020 Apr 18.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/all.14326DOI Listing
April 2020
6.028 Impact Factor

Review of Health Consequences of Electronic Cigarettes and the Outbreak of Electronic Cigarette, or Vaping, Product Use-Associated Lung Injury.

J Med Toxicol 2020 Apr 16. Epub 2020 Apr 16.

North Texas Poison Center, Parkland Health and Hospital System, Dallas, TX, USA.

Electronic cigarettes (e-cigarettes) are battery-operated devices to insufflate nicotine or other psychoactive e-liquid aerosols. Despite initial claims of e-cigarettes as a nicotine-cessation device, aggressive marketing of e-cigarettes has led to an explosion in adolescents' and young adults' use over the last few years. Coupled with a lack of adequate investigation and regulation of e-cigarettes, the USA is facing an outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) starting in mid-2019. Read More

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http://dx.doi.org/10.1007/s13181-020-00772-wDOI Listing

Phenotypical Sub-setting of the First Episode of Severe Viral Respiratory Infection Based on Clinical Assessment and Underlying Airway Disease: A Pilot Study.

Front Pediatr 2020 2;8:121. Epub 2020 Apr 2.

Division of Pediatric Pulmonary and Sleep Medicine. Center for Genetic Research, Children's National Medical Center, George Washington University, Washington, DC, United States.

Viral bronchiolitis is a term often used to group all infants with the first episode of severe viral respiratory infection. However, this term encompasses a collection of different clinical and biological processes. We hypothesized that the first episode of severe viral respiratory infection in infants can be subset into clinical phenotypes with distinct outcomes and underlying airway disease patterns. Read More

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http://dx.doi.org/10.3389/fped.2020.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142213PMC

Risk Factors for Respiratory Syncytial Virus Bronchiolitis Admissions.

Ir Med J 2020 01 16;113(1). Epub 2020 Jan 16.

Children's Health Ireland at Crumlin (CHI@Crumlin), Dublin, Ireland.

Aim Determine the seasonal incidence of hospital Respiratory Syncytial Virus (RSV) bronchiolitis and explore the variables associated with admission to ward versus the Paediatric Intensive Care Unit (PICU). Method Retrospective case-control study. Children, aged ≤2 years, between November and March, over a 3 year period with a positive RSV nasopharyngeal aspirate test. Read More

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January 2020

Actively Doing Less: Deimplementation of Unnecessary Interventions in Bronchiolitis Care Across Urgent Care, Emergency Department, and Inpatient Settings.

Hosp Pediatr 2020 May 13;10(5):385-391. Epub 2020 Apr 13.

Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri.

Background And Objectives: Quality improvement (QI) initiatives have increased provider adherence to individual components of a bronchiolitis clinical practice guideline (CPG). Few have evaluated complete adherence to a guideline in multiple types of care settings. Our aim with this study was to increase complete adherence to our institutional bronchiolitis CPG in urgent care center, emergency department, and inpatient settings. Read More

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http://dx.doi.org/10.1542/hpeds.2019-0284DOI Listing

Predictors for the prescription of albuterol in infants hospitalized for viral bronchiolitis.

Allergol Immunopathol (Madr) 2020 Apr 8. Epub 2020 Apr 8.

Department of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Avenida Calle 127 No. 20-78, Bogota, Colombia; Department of Pediatric Pulmonology and Pediatric Critical Care Medicine, School of Medicine, Universidad El Bosque, Bogota, Colombia. Electronic address:

Introduction And Objectives: Despite the recommendation against routine use of inhaled bronchodilators in infants with viral bronchiolitis given in the main clinical practice guidelines (CPGs) on viral bronchiolitis, albuterol is widely prescribed to patients with this disease. The aim of this study was to identify predictors of prescription of albuterol in a population of infants hospitalized for viral bronchiolitis.

Material And Methods: An analytical cross-sectional study performed during the period from March 2014 to August 2015, in a random sample of patients <2 years old hospitalized in the Fundacion Hospital La Misericordia, a hospital located in Bogota, Colombia. Read More

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http://dx.doi.org/10.1016/j.aller.2019.10.007DOI Listing

First-line oxygen therapy with high-flow in bronchiolitis is not cost saving for the health service.

Arch Dis Child 2020 Apr 10. Epub 2020 Apr 10.

Paediatric Critical Care Research Group, The University of Queensland Child Health Research Centre, South Brisbane, Queensland, Australia

Background: Bronchiolitis is the most common reason for hospital admission in infants. High-flow oxygen therapy has emerged as a new treatment; however, the cost-effectiveness of using it as first-line therapy is unknown.

Objective: To compare the cost of providing high-flow therapy as a first-line therapy compared with rescue therapy after failure of standard oxygen in the management of bronchiolitis. Read More

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http://dx.doi.org/10.1136/archdischild-2019-318427DOI Listing
April 2020
2.899 Impact Factor

High flow nasal cannula as respiratory support in treating infant bronchiolitis: a systematic review.

Eur J Pediatr 2020 May 31;179(5):711-718. Epub 2020 Mar 31.

Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.

Bronchiolitis is a common respiratory illness in early childhood, often leading to hospitalization and associated healthcare costs. Low flow 100% oxygen through nasal prongs is the standard therapy for infants with bronchiolitis and hypoxemia. Nasal continuous positive airway pressure (nCPAP) or invasive ventilation is used in case of progressive respiratory failure. Read More

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http://dx.doi.org/10.1007/s00431-020-03637-0DOI Listing

Immunological and Inflammatory Biomarkers of Susceptibility and Severity in Adult Respiratory Syncytial Virus Infections.

J Infect Dis 2020 Mar 30. Epub 2020 Mar 30.

National Heart and Lung Institute, Imperial College, London, UK.

Background: . Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in young infants. However, it is also a significant pathogen in older adults. Read More

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http://dx.doi.org/10.1093/infdis/jiaa063DOI Listing

Case Report: Exome Sequencing Reveals LRBA Deficiency in a Patient With End-Stage Renal Disease.

Front Pediatr 2020 11;8:42. Epub 2020 Mar 11.

Faculty of Medicine and University Hospital Cologne, Institute of Human Genetics, University of Cologne, Cologne, Germany.

Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency is characterized by autoimmunity, chronic diarrhea, and immunodeficiency. Minor renal manifestations have been found in a few patients, but kidney disease has not been systematically studied and may remain underdiagnosed in this highly variable entity. Our patient initially presented with pancytopenia, enteropathy, hypogammaglobulinemia, and failure to thrive at the age of 15 months. Read More

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http://dx.doi.org/10.3389/fped.2020.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078106PMC

High-Flow Nasal Cannula Therapy for Pediatric Patients With Bronchiolitis: Time to Put the Horse Back in the Barn.

Authors:
Shawn L Ralston

JAMA Pediatr 2020 Mar 23. Epub 2020 Mar 23.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jamapediatrics.2020.0040DOI Listing

Pharmacokinetics, Safety and Antiviral Effects of Multiple Doses of the Respiratory Syncytial Virus Fusion Protein Inhibitor, JNJ-53718678, in Infants Hospitalized with RSV Infection: A Randomized Phase 1b Study.

Clin Infect Dis 2020 Mar 23. Epub 2020 Mar 23.

Global Clinical Development Infectious Diseases, Janssen Research & Development, Beerse, Belgium.

Background: This Phase 1b study evaluated the pharmacokinetics, safety and antiviral effects of the respiratory syncytial virus (RSV)-specific fusion inhibitor JNJ-53718678 (JNJ8678) in hospitalized RSVinfected patients (aged >1-≤24 months).

Methods: Patients categorized by age (Cohort 1: ≥6-≤24 months; Cohort 2: ≥3-<6 months; Cohort 3: >1-<3 months) were randomized to oral JNJ-8678 or placebo once-daily for 7 days. Dose increases followed Data Review Committee recommendations (doses respectively: Cohort 1: 2/6/8/9 mg/kg; Cohort 2: 1. Read More

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http://dx.doi.org/10.1093/cid/ciaa283DOI Listing
March 2020
8.886 Impact Factor

Virus, allergic sensitisation and cortisol in infant bronchiolitis and risk of early asthma.

ERJ Open Res 2020 Jan 16;6(1). Epub 2020 Mar 16.

Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Background: Acute bronchiolitis during infancy and human rhinovirus (HRV) lower respiratory tract infections increases the risk of asthma in atopic children. We aimed to explore whether specific viruses, allergic sensitisation or cortisol levels during acute bronchiolitis in infancy increase the risk of early asthma, using recurrent wheeze as a proxy.

Methods: In 294 children with a mean (range) age of 4. Read More

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http://dx.doi.org/10.1183/23120541.00268-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073413PMC
January 2020

Does Normal Saline Have Clinical Effects in Infants with Bronchiolitis?: Pediatric Pulmonologist's Viewpoint.

Authors:
Sarika Gupta

Indian Pediatr 2020 Mar;57(3):257

Department of Pediatrics, KGMU, Lucknow, India.

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Does Normal Saline Have Clinical Effects in Infants with Bronchiolitis?: Evidence-based Medicine Viewpoint.

Authors:
Joseph L Mathew

Indian Pediatr 2020 Mar;57(3):254-257

Department of Pediatrics, PGIMER, Chandigarh, India.

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High-flow nasal cannula for bronchiolitis in an ICU and step-down unit.

Can J Respir Ther 2019 28;56:5-6. Epub 2020 Feb 28.

Department of Pediatrics, Division of Pediatric Emergency Medicine, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.29390/cjrt-2019-023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058108PMC
February 2020

Discharge Criteria Decrease Variability and Improve Efficiency.

Hosp Pediatr 2020 Apr 16;10(4):318-324. Epub 2020 Mar 16.

Department of Pediatrics, School of Medicine, Virginia Commonwealth University, Children's Hospital of Richmond, Richmond, Virginia.

Background And Objectives: To determine the effect of discharge criteria on discharge readiness and length of stay (LOS). Discharge inefficiency is a common barrier to hospital flow, affecting admissions, discharges, cost, patient satisfaction, and quality of care. Our center identified increasing discharge efficiency as a method to improve flow and better meet the needs of our patients. Read More

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http://dx.doi.org/10.1542/hpeds.2019-0244DOI Listing

Quantitative CT analysis for bronchiolitis obliterans in perinatally HIV-infected adolescents-comparison with controls and lung function data.

Eur Radiol 2020 Mar 14. Epub 2020 Mar 14.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, USA.

Objective: To compare quantitative chest CT parameters in perinatally HIV-infected adolescents with and without bronchiolitis obliterans compared with HIV-uninfected controls and their association with lung function measurements.

Materials And Methods: Seventy-eight (41 girls) HIV-infected adolescents with a mean age of 13.8 ± 1. Read More

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http://dx.doi.org/10.1007/s00330-020-06789-7DOI Listing

Club cell 10-kDa protein (CC10) inhibits cPLA2/COX2 pathway to alleviate RSV-induced airway inflammation and AHR.

Int Immunopharmacol 2020 Jun 12;83:106327. Epub 2020 Mar 12.

Department of Respiratory Medicine, Chongqing Key Laboratory of Pediatrics, Childreńs Hospital, Chongqing Medical University, Chongqing 400014, PR China. Electronic address:

Respiratory syncytial virus (RSV) is the most common viral pathogen causing acute lower respiratory tract infections (LRTI) in infants. Airway epithelial cells, including Club cells, are primary targets of RSV infection. The "Club cell 10-kDa protein" (CC10), produced mainly by Club cells, possesses anti-inflammatory and immunoregulatory properties that are relevant in infection, injury, and allergic reactions. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106327DOI Listing

Seasonality of Respiratory Syncytial Virus Hospitalization.

Adv Exp Med Biol 2020 Mar 14. Epub 2020 Mar 14.

Department of Pediatrics, Center of Postgraduate Medical Education, Warsaw, Poland.

Seasonality of respiratory syncytial virus (RSV) infection is an area of limited knowledge. In this study, we set out to get insight into the epidemic characteristics of RSV. We retrospectively evaluated medical files of 512 hospitalizations in children due to RSV infection from January 2010 to July 2017. Read More

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http://dx.doi.org/10.1007/5584_2020_503DOI Listing