Ann Surg 2020 Dec 29. Epub 2020 Dec 29.
*Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit, Amsterdam, The Netherlands †University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK; Department of Paediatric Surgery and Urology, Southampton Children's Hospital, Southampton, UK ‡Parent and Patient representative, USA §Pediatric clinical Research Office, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands ¶Knowledge Institute of the Dutch Association of Medical Specialists, Utrecht, The Netherlands ||Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada **Center for Surgical Outcomes Research, Abigail Wexner Research Institute and Department of Surgery, Nationwide Children's Hospital, Columbus, OH, USA ††Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden ‡‡Department of Surgery, Children's Mercy Hospital, Kansas City, MO, USA §§Department of Pediatric Surgery, Sydney Children's Hospital, Randwick, NSW, Australia, School of Women's and Children's Health, University of New South Wales ¶¶Department of Pediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore ||||Division of Paediatric Surgery, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ***Department of Pediatric Surgery, British Columbia Children's Hospital, Vancouver, BC, Canada †††Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada ‡‡‡Department of Surgery, University of Toronto, Toronto, ON, Canada §§§Harvey E. Beardmore Division of Pediatric Surgery, Montreal Children's Hospital, Montreal, QC, Canada ¶¶¶Department of Pediatric Surgery, Helsinki Children's Hospital, Helsinki, Finland ||||||Department of Pediatric Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia ****Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Objective:: To develop an international Core Outcome Set (COS), a minimal collection of outcomes that should be measured and reported in all future clinical trials evaluating treatments of acute simple appendicitis in children.
Summary Background Data: A previous systematic review identified 115 outcomes in 60 trials and systematic reviews evaluating treatments for children with appendicitis, suggesting the need for a COS.
Methods: The development process consisted of four phases: (1) an updated systematic review identifying all previously reported outcomes, (2) a two-stage international Delphi study in which parents with their children and surgeons rated these outcomes for inclusion in the COS, (3) focus groups with young people to identify missing outcomes, and (4) international expert meetings to ratify the final COS. Read More