3,729 results match your criteria Pediatrics Apnea


Nasal cytology in children with primary snoring and obstructive sleep apnoea syndrome.

Int J Pediatr Otorhinolaryngol 2019 Apr 17;122:133-137. Epub 2019 Apr 17.

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy. Electronic address:

Objective: Rhinitis is an acute or chronic inflammatory condition due to several causes (i.e. infections, allergens). Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.04.015DOI Listing

Enhanced interleukin-8 production in mononuclear cells in severe pediatric obstructive sleep apnea.

Allergy Asthma Clin Immunol 2019 16;15:23. Epub 2019 Apr 16.

2Department of Anesthesia, McGill University Health Center, 1001 Decarie Boulevard, Montreal, QC H4A 3J1 Canada.

Background: Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, metabolic disorders, and cognitive dysfunction. Current thinking links chronic intermittent hypoxia (CIH) with oxidative stress and systemic inflammation. However, the sequence of events leading to the morbidities associated with OSA is poorly understood in children. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-019-0338-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469051PMC
April 2019
1 Read

Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis.

Ci Ji Yi Xue Za Zhi 2019 Apr-Jun;31(2):113-117

Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Objective: Prone sleep is an identified risk factor for sudden infant death syndrome, possibly due to reduced blood pressure, cerebral oxygenation, and impaired cerebral vascular control. Cardiac and respiratory responses in neonates during supine and prone sleep have not been reported.

Materials And Methods: In this study, daytime polysomnography (PSG) data from 17 neonates aged 2-3 days during supine and prone sleep were reported and the NDN gene, an important gene for neonatal respiratory control, was sequenced for correlation with neonatal respiratory parameters. Read More

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http://www.tcmjmed.com/text.asp?2019/31/2/113/236553
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http://dx.doi.org/10.4103/tcmj.tcmj_29_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450148PMC
April 2019
1 Read

Retropharyngeal Tuberculous Abscess: A Rare Cause of Upper Airway Obstruction and Obstructive Sleep Apnea in Children: A Case Report.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

Pediatric Pulmonology, Hamburg University, Hamburg, Germany.

Retropharyngeal tuberculous abscess (RPTBA) is a rare manifestation of tuberculosis (TB) even in high TB burden areas. It rarely manifests as a cause of upper airway obstruction and obstructive sleep apnea (OSA) in children with few case reports in the literature. We report a 22 months old toddler who presented with upper airway obstruction and OSA and was diagnosed with RPTBA. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/tropej/fmz018DOI Listing
April 2019
1 Read

Sleep-related breathing disorders in young adults with Prader-Willi syndrome: a placebo-controlled, cross-over GH trial.

J Clin Endocrinol Metab 2019 Apr 18. Epub 2019 Apr 18.

Dutch Growth Research Foundation, Rotterdam, The Netherlands.

Context: Sleep-related breathing disorders (SRBD) are common in people with Prader-Willi syndrome (PWS). Young adults with PWS benefit from GH continuation after adult height by maintaining the improved body composition obtained during childhood. There are, however, no studies about the effects of GH on SRBD in young adults with PWS who were treated with GH during childhood. Read More

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http://dx.doi.org/10.1210/jc.2019-00391DOI Listing
April 2019
1 Read

What Is New about Transfusions for Preterm Infants? An Update.

Neonatology 2019 Apr 11;115(4):406-410. Epub 2019 Apr 11.

Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Currently the question of whether to maintain a higher hemoglobin level by transfusing more liberally, as opposed to a more restrictive strategy with lower hemoglobin maintenance levels, has not been answered. We review summarized conclusions of a Cochrane systematic review and meta-analysis of 614 infants in 4 randomized controlled trials (RCT) pooling data. This suggests potential benefits of higher hemoglobin levels, i. Read More

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http://dx.doi.org/10.1159/000499048DOI Listing
April 2019
2 Reads

Obesity class versus the Edmonton Obesity Staging System for Pediatrics to define health risk in childhood obesity: results from the CANPWR cross-sectional study.

Lancet Child Adolesc Health 2019 Apr 2. Epub 2019 Apr 2.

Population Health Research Institute, Hamilton, ON, Canada; Department of Pediatrics, McMaster University, Hamilton, ON, Canada; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada. Electronic address:

Background: Disease severity in paediatric obesity is usually defined using the body-mass index (BMI). Although informative at the population level, its usefulness on an individual level has limitations. The use of a clinical staging system-Edmonton Obesity Staging System for Pediatrics (EOSS-P)-in identifying health risk has been proposed. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30056-2DOI Listing
April 2019
1 Read

Persistent Central Apnea and Long-Term Outcome After Posterior Fossa Decompressive Surgery for Arnold Chiari Type 1 Malformation in a Pediatric Patient.

J Clin Sleep Med 2019 Apr 15;15(4):667-671. Epub 2019 Apr 15.

Sleep Center, Division of Respiratory Diseases, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Abstract: Arnold Chiari malformation (ACM) is the most common cause of central sleep apnea (CSA) in otherwise healthy children. Although there are several case reports and series reported on this topic, there are limited descriptions of the long-term course of these children after the surgical interventions. Posterior fossa decompression surgery to relieve pressure of the herniating cerebellum on the brainstem is generally thought to significantly improve CSA in most cases, however, there are very limited data on the natural course of CSA in children following decompression surgery. Read More

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http://dx.doi.org/10.5664/jcsm.7740DOI Listing
April 2019
2 Reads

Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome).

Genet Med 2019 Apr 3. Epub 2019 Apr 3.

PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.

Purpose: A new syndrome with hypotonia, intellectual disability, and eye abnormalities (HIDEA) was previously described in a large consanguineous family. Linkage analysis identified the recessive disease locus, and genome sequencing yielded three candidate genes with potentially pathogenic biallelic variants: transketolase (TKT), transmembrane prolyl 4-hydroxylase (P4HTM), and ubiquitin specific peptidase 4 (USP4). However, the causative gene remained elusive. Read More

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http://www.nature.com/articles/s41436-019-0503-4
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http://dx.doi.org/10.1038/s41436-019-0503-4DOI Listing
April 2019
3 Reads

Strengthening the Chain of Survival: Cardiopulmonary Resuscitation Workshop for Caregivers of Children at Risk.

Pediatr Qual Saf 2019 Jan-Feb;4(1):e141. Epub 2019 Feb 7.

Department of Pediatrics, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

Background: Parents and caregivers should receive training regarding pediatric cardiopulmonary resuscitation (CPR) because this knowledge improves survival. We conducted a study as part of a Patient Safety Project to improve caregivers' CPR knowledge and skills. We also aimed to improve the quality of patient care. Read More

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http://dx.doi.org/10.1097/pq9.0000000000000141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426491PMC
February 2019
6 Reads

Sleep-Disordered Breathing Is Associated with Reduced Mandibular Cortical Width in Children.

JDR Clin Trans Res 2019 Jan 22;4(1):58-67. Epub 2018 May 22.

1 School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Introduction:: Evidence from the adult population suggests that sleep-disordered breathing (SDB) (i.e., obstructive sleep apnea [OSA]) is negatively associated with bone mineral density. Read More

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http://dx.doi.org/10.1177/2380084418776906DOI Listing
January 2019
2 Reads

Effect of positive airway pressure therapy in children with obstructive sleep apnea syndrome: does positive airway pressure use reduce pedestrian injury risk?

Sleep Health 2019 Apr 14;5(2):161-165. Epub 2019 Jan 14.

University of Alabama at Birmingham, Department of Psychology, Birmingham, AL. Electronic address:

Introduction: Treatment with positive airway pressure (PAP) therapy reduces injury risk among adults with obstructive sleep apnea syndrome (OSAS), but the effect of PAP therapy on children's injury risk is unknown. This study investigated whether treatment of OSAS with PAP reduces children's pedestrian injury risk in a virtual reality pedestrian environment.

Methods: Forty-two children ages 8-16 years with OSAS were enrolled upon diagnosis by polysomnography. Read More

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http://dx.doi.org/10.1016/j.sleh.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443098PMC
April 2019
2 Reads

Craniofacial and occlusal development in 2.5-year-old children with obstructive sleep apnoea syndrome.

Eur J Orthod 2019 Mar 29. Epub 2019 Mar 29.

Department of Ear and Oral Diseases, Tampere University Hospital.

Objectives: Paediatric obstructive sleep apnoea syndrome (OSAS) is associated with a range of changes in craniofacial and occlusal development. There is, however, little knowledge of how early in life these changes can be found. The aim of the present study was to determine whether changes in dental arch morphology, occlusion, facial profile, tonsil size, breathing habit or body mass index (BMI) can already be found among 2. Read More

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https://academic.oup.com/ejo/advance-article/doi/10.1093/ejo
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http://dx.doi.org/10.1093/ejo/cjz009DOI Listing
March 2019
10 Reads

Intermittent hypoxia in preterm infants: Measurement using the desaturation index.

Pediatr Pulmonol 2019 Mar 28. Epub 2019 Mar 28.

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Objective: The aims of this study were to: (i) Determine in preterm infants at neonatal discharge the prevalence of intermittent hypoxia (IH), as measured by the oxygen desaturation index (DSI) recorded by pulse oximetry and (ii) Determine the change in values for very preterm infants at 1-month post discharge.

Methods: Preterm infants were recruited from the Wellington regional neonatal intensive care unit (NICU) and 24-h pulse oximetry recordings performed immediately before discharge. Infants born <32 weeks gestational age (GA) had repeat oximetry 1-month post discharge. Read More

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http://dx.doi.org/10.1002/ppul.24276DOI Listing

How OSA Evolves From Childhood to Young Adulthood: Natural History From a 10-Year Follow-up Study.

Chest 2019 Mar 26. Epub 2019 Mar 26.

Department of Pediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Background: Understanding the natural history of childhood OSA can help to determine disease prognosis and to guide risk stratification and management strategies.

Methods: To evaluate the natural history of childhood OSA and factors associated with spontaneous remission and persistent and incident OSA from childhood to late adolescence/early adulthood, a longitudinal analysis of a prospective community-based cohort was designed. Subjects from a cohort established for an OSA prevalence study were invited to participate in this 10-year follow-up study. Read More

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http://dx.doi.org/10.1016/j.chest.2019.03.007DOI Listing
March 2019
1 Read

Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.

Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205

15 Department of Research and Quality, American Academy of Otolaryngology-Head and Neck Surgery Foundation, Alexandria, Virginia, USA.

Objective: This update of a 2011 guideline developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation provides evidence-based recommendations on the pre-, intra-, and postoperative care and management of children 1 to 18 years of age under consideration for tonsillectomy. Tonsillectomy is defined as a surgical procedure performed with or without adenoidectomy that completely removes the tonsil, including its capsule, by dissecting the peritonsillar space between the tonsil capsule and the muscular wall. Tonsillectomy is one of the most common surgical procedures in the United States, with 289,000 ambulatory procedures performed annually in children <15 years of age, based on the most recent published data. Read More

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http://dx.doi.org/10.1177/0194599818807917DOI Listing
February 2019
2 Reads

Correlation between cephalometric variables and obstructive sleep apnoea severity in children.

Eur J Paediatr Dent 2019 Mar;20(1):43-47

DDS, PhD, Section of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II", Naples, Italy.

Aim: Alterations in craniofacial growth have been associated with obstructive sleep apnoea in children. The main objectives of this study were to analyse the correlation between cephalometric variables and Obstructive Apnea/Hypopnea Index (OAHI) in order to investigate if craniofacial features may influence the severity of obstructive sleep apnoea and to study the correlation between upper nasopharyngeal width and maxillomandibular skeletal discrepancy in sagittal and vertical plane.

Materials And Methods: Study Design: Correlations between cephalometric variables and obstructive sleep apnoea/hypopnea index and between upper airways space and maxillomandibular skeletal discrepancy were investigated. Read More

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http://dx.doi.org/10.23804/ejpd.2019.20.01.09DOI Listing
March 2019
2 Reads

Adherence to Guidelines for Screening Polysomnography in Children with Down Syndrome.

Otolaryngol Head Neck Surg 2019 Mar 26:194599819837243. Epub 2019 Mar 26.

1 Division of Pediatric Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Objectives: To compare the percentage and mean age of children with Down syndrome (DS) who underwent polysomnography (PSG) to evaluate for obstructive sleep apnea (OSA) before and after the introduction of the American Academy of Pediatrics guidelines recommending universal screening by age 4 years.

Study Design: Retrospective cohort study.

Setting: Single tertiary pediatric hospital. Read More

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http://dx.doi.org/10.1177/0194599819837243DOI Listing
March 2019
11 Reads

Safety and immunogenicity of pneumococcal conjugate vaccines in preterm infants.

Expert Opin Drug Saf 2019 Mar 23:1-7. Epub 2019 Mar 23.

a Translational Paediatrics and Infectious Diseases, Department of Paediatrics , Hospital Clínico Universitario de Santiago de Compostela , Santiago de Compostela , Spain.

Introduction: The introduction of pneumococcal conjugate vaccines (PCVs) in the routine immunization program has resulted in a significant decline in invasive pneumococcal diseases (IPD) around the world. Preterm infants are a special group at a high risk of invasive infection by encapsulated bacteria. However, their slow growth accrual and prolonged hospital stay frequently lead to delays in immunization, which contributes to their risk for severe infections. Read More

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http://dx.doi.org/10.1080/14740338.2019.1597849DOI Listing
March 2019
1 Read

Tracheoscopic Findings and Their Impact on Respiratory Symptoms in Children with Esophageal Atresia.

Eur J Pediatr Surg 2019 Mar 21. Epub 2019 Mar 21.

Division of Pediatric Surgery, Universitat zu Koln Medizinische Fakultat, Koln, Nordrhein-Westfalen, Germany.

Introduction:  Esophageal atresia (EA) is often accompanied by tracheobronchial malformations leading to stridor, recurrent bronchitis, and occasionally to life-threatening obstructive apnea after surgical repair. The aim of this study was to identify the presence of tracheomalacia in patients with EA and tracheoesophageal fistula (TEF) pre- and postoperatively and to find endoscopic correlates leading to clinical airway symptoms.

Methods:  In a cohort of 362 patients with EA-TEF who underwent 595 tracheoscopies at the Children's Hospital of Cologne between January 1983 and December 2002, impaired tracheal lumen, localization of TEF, tracheal pulsations, and corresponding clinical symptoms were retrospectively analyzed. Read More

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http://dx.doi.org/10.1055/s-0039-1683871DOI Listing
March 2019
5 Reads

Effect of ketofol versus propofol as an induction agent on ease of laryngeal mask airway insertion conditions and hemodynamic stability in pediatrics: an observational prospective cohort study.

BMC Anesthesiol 2019 Mar 20;19(1):41. Epub 2019 Mar 20.

Aksum University, PO box 298, Aksum City, Tigray, Ethiopia.

Background: Laryngeal mask airway is a supraglottic airway device which has led to a fundamental change in the management of modern general anesthesia. In the present study; we evaluated the laryngeal mask airway insertion conditions and hemodynamic changes comparing ketamine-propofol mixture (ketofol) with propofol. The study was to compare the ketamine-propofol mixture (ketofol) with propofolon the ease of laryngeal mask airway insertion conditions and hemodynamic effects for induction of general anesthesia. Read More

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http://dx.doi.org/10.1186/s12871-019-0711-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425569PMC
March 2019
1.333 Impact Factor

Clinical Determination of Brain Death in Children Supported by Extracorporeal Membrane Oxygenation.

Neurocrit Care 2019 Mar 19. Epub 2019 Mar 19.

Division of Neurology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA.

Background/objective: Children supported by extracorporeal membrane oxygenation (ECMO) are at risk of catastrophic neurologic injury and brain death. Timely determination of brain death is important for minimizing psychological distress for families, resource allocation, and organ donation. Reports of successful determination of brain death in pediatric patients supported by ECMO are limited. Read More

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http://dx.doi.org/10.1007/s12028-019-00700-zDOI Listing
March 2019
1 Read

Chemoreflex failure and sleep-disordered breathing in familial dysautonomia: Implications for sudden death during sleep.

Auton Neurosci 2019 May 15;218:10-15. Epub 2019 Feb 15.

Department of Neurology, Dysautonomia Center, New York University School of Medicine, New York, NY, United States of America. Electronic address:

Familial dysautonomia (Riley-Day syndrome, hereditary sensory and autonomic neuropathy type III) is a rare autosomal recessive disease characterized by impaired development of primary sensory and autonomic neurons resulting in a severe neurological phenotype, which includes arterial baroreflex and chemoreflex failure with high frequency of sleep-disordered breathing and sudden death during sleep. Although a rare disease, familial dysautonomia represents a unique template to study the interactions between sleep-disordered breathing and abnormal chemo- and baroreflex function. In patients with familial dysautonomia, ventilatory responses to hypercapnia are reduced, and to hypoxia are almost absent. Read More

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http://dx.doi.org/10.1016/j.autneu.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428199PMC
May 2019
2 Reads

Increased risk of central serous chorioretinopathy following end-stage renal disease: A nationwide population-based study.

Medicine (Baltimore) 2019 Mar;98(11):e14859

Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan.

This retrospective, nationwide, matched cohort study investigated the risk of central serous chorioretinopathy (CSCR) following end-stage renal disease (ESRD). The study cohort included 84722 ESRD patients who were registered between January 2000 and December 2009 at the Taiwan National Health Insurance Research Database. An age- and sex-matched control group comprised 84722 patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Read More

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http://dx.doi.org/10.1097/MD.0000000000014859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426587PMC
March 2019
7 Reads

Comparison of Caffeine versus Theophylline for apnea of prematurity.

Pak J Med Sci 2019 Jan-Feb;35(1):113-116

Dr. Zafar Ali Ch., MBBS, FCPS, FRCS. Department of Pediatrics, Medicine Govt. Khawaja Muhammad Safdar Medical College & Govt. Allama Iqbal Memorial Teaching Hospital, Sialkot, Pakistan.

Objective: To make a comparison between standard doses of theophylline and caffeine for the treatment of apnea of prematurity.

Methods: A randomised control trail was conducted in Department of Pediatrics Medicine Govt. Khawaja Muhammad Safdar Medical College and Govt. Read More

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http://dx.doi.org/10.12669/pjms.35.1.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408648PMC

Clinical presentation and early predictors for poor outcomes in pediatric myocarditis: A retrospective study.

World J Clin Cases 2019 Mar;7(5):548-561

Department of Pediatric Nephrology, Puerta del Mar University Hospital, Cadiz 11009, Spain.

Background: Myocarditis is an important cause of morbidity and mortality in children, leading to long-term sequelae including chronic congestive heart failure, dilated cardiomyopathy, heart transplantation, and death. The initial diagnosis of myocarditis is usually based on clinical presentation, but this widely ranges from the severe sudden onset of a cardiogenic shock to asymptomatic patients. Early recognition is essential in order to monitor and start supportive treatment prior to the development of severe adverse events. Read More

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https://www.wjgnet.com/2307-8960/full/v7/i5/548.htm
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http://dx.doi.org/10.12998/wjcc.v7.i5.548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406197PMC
March 2019
4 Reads

Immediate and delayed decrease of long term potentiation and memory deficits after neonatal intermittent hypoxia.

Int J Dev Neurosci 2019 May 9;74:27-37. Epub 2019 Mar 9.

Department of Pediatrics, NorthShore University HealthSystem Research Institute, 2650 Ridge Ave 60201, Evanston, IL, USA. Electronic address:

Apnea of prematurity is a common clinical condition that occurs in premature infants and results in intermittent hypoxia (IH) to brain and other organs. While short episodes of apnea are considered of no clinical significance, prolonged apnea with bradycardia and large oxygen desaturation is associated with adverse neurological and cognitive outcome. The mechanisms of cognitive deficits in IH are poorly understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183034
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http://dx.doi.org/10.1016/j.ijdevneu.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461389PMC
May 2019
10 Reads

Polysomnography Reference Values in Healthy Newborns.

J Clin Sleep Med 2019 Mar 15;15(3):437-443. Epub 2019 Mar 15.

Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina.

Study Objectives: Polysomnography (PSG) is increasingly used in the assessment of infants. Newborn PSG reference values based on recent standardization are not available. This study provides reference values for PSG variables in healthy newborn infants. Read More

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http://dx.doi.org/10.5664/jcsm.7670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411184PMC
March 2019
1 Read

The Use of Computer Decision Support for Pediatric Obstructive Sleep Apnea Detection in Primary Care.

J Clin Sleep Med 2019 Mar 15;15(3):453-462. Epub 2019 Mar 15.

Children's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.

Study Objectives: To (1) describe outcomes from a computer decision support system (CDSS) for pediatric obstructive sleep apnea (OSA) detection in primary care; and (2) identity the prevalence of children meeting criteria for an OSA referral.

Methods: A CDSS for OSA was implemented in two urban primary care clinics. Parents of children (age 2 to 11 years) presenting to the clinic were asked if their child snored regularly, with a positive response resulting in six additional OSA screening items. Read More

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http://dx.doi.org/10.5664/jcsm.7674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411194PMC
March 2019
1 Read

Obstructive Sleep Apnea in Children With Beckwith-Wiedemann Syndrome.

J Clin Sleep Med 2019 Mar 15;15(3):375-381. Epub 2019 Mar 15.

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Study Objectives: Beckwith-Wiedemann syndrome (BWS) is a rare pediatric overgrowth disorder that includes a spectrum of clinical findings including macroglossia, especially in those with loss of methylation at the imprinting control region (IC2 LOM) on chromosome 11. Children with BWS can have very severe obstructive sleep apnea (OSA), but the prevalence of OSA in this population is poorly understood, as is the relationship between OSA and the BWS genotype/phenotype. We hypothesized that there would be a high prevalence of OSA in children with BWS, and that OSA would be more severe in children with IC2 LOM. Read More

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http://dx.doi.org/10.5664/jcsm.7656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411187PMC
March 2019
1 Read

Oral Health and Oral Health-Related Quality of Life in Children With Obstructive Sleep Apnea.

J Clin Sleep Med 2019 Mar 15;15(3):445-452. Epub 2019 Mar 15.

Department of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Washington School of Medicine, Seattle, Washington.

Study Objectives: This aim of this study was to evaluate oral health and oral health-related quality of life (OHRQoL) in children with obstructive sleep apnea (OSA).

Methods: This cross-sectional study involved 31 children who had baseline polysomnography studies and in whom a diagnosis of OSA was made by a sleep physician. They were evaluated against 36 control patients who, based on parent responses to the Pediatric Sleep Questionnaire, were at very low risk for having sleep problems. Read More

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http://dx.doi.org/10.5664/jcsm.7672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411169PMC
March 2019
2 Reads

Screening for sleep-disordered breathing with Pediatric Sleep Questionnaire in children with underlying conditions.

J Sleep Res 2019 Mar 7. Epub 2019 Mar 7.

Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital for Children, London, UK.

The Pediatric Sleep Questionnaire described by Chervin et al. (Sleep Medicine, 2000, 1, 21-32) was originally validated for children with obstructive sleep apnoea syndrome but without other disorders. The aim of our study was to check the applicability of this questionnaire in children with underlying chronic medical conditions. Read More

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http://dx.doi.org/10.1111/jsr.12826DOI Listing
March 2019
1 Read

Pollen levels on the day of polysomnography influence sleep disordered breathing severity in children with allergic rhinitis.

Sleep Breath 2019 Mar 5. Epub 2019 Mar 5.

The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, Australia.

Purpose: Allergic rhinitis (AR) is a common risk factor for sleep disordered breathing (SDB) in children. Allergy to pollen is a trigger for allergic rhinitis, causing nasal inflammation, upper airway congestion and obstruction. We aimed to determine if the pollen count on the day of diagnostic polysomnography for SDB affected the result. Read More

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http://dx.doi.org/10.1007/s11325-019-01819-1DOI Listing
March 2019
2 Reads

Quantitative assessment of nocturnal neural respiratory drive in children with and without obstructive sleep apnoea using surface EMG.

Exp Physiol 2019 Mar 1. Epub 2019 Mar 1.

Respiratory Department, Sydney Children's Hospital, Randwick, NSW, Australia.

New Findings: What is the central question of this study? Recent studies have suggested potential utility of non-normalized respiratory muscle EMG as an index of neural respiratory drive (NRD). Whether NRD measured using non-normalized surface EMG of the lateral chest wall overlying the diaphragm (sEMGcw) recorded during nocturnal clinical polysomnography can differentiate children with and without obstructive sleep apnoea (OSA) is not known. What is the main finding and its importance? Non-normalized sEMGcw was increased in children with OSA and an additional group of snoring children without OSA but subjectively increased respiratory effort compared with primary snorers. Read More

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http://dx.doi.org/10.1113/EP087441DOI Listing
March 2019
2 Reads

Introduction to Obstructive Sleep Apnea for the Internist.

MedEdPORTAL 2018 Oct 9;14:10761. Epub 2018 Oct 9.

Assistant Professor, Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington School of Medicine.

Introduction: The prevalence of sleep-disordered breathing is increasing, and there are insufficient sleep medicine specialists to meet the clinical demand of caring for these patients. One way to meet this clinical need is to train primary care and internal medicine physicians to provide some of the care. However, trainees in these specialties often receive very little training on practical aspects of the management of obstructive sleep apnea (OSA). Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346284PMC
October 2018

Three cases of transient neonatal pseudohypoparathyroidism.

Sudan J Paediatr 2018 ;18(2):42-47

Department of Clinical Biochemistry, Klatovy Hospital, Klatovy, Czech Republic.

Neonatal hypocalcemia is defined as serum calcium (S-Ca) < 2.0 mmol/l in full-term newborns and <1.75 mmol/l in preterm newborns. Read More

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https://www.ejmanager.com/fulltextpdf.php?mno=289314
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http://dx.doi.org/10.24911/SJP.106-1516889879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378568PMC
January 2018
8 Reads

Clinical Practice Guideline: Tonsillectomy in Children (Update).

Otolaryngol Head Neck Surg 2019 Feb;160(1_suppl):S1-S42

15 Department of Research and Quality, American Academy of Otolaryngology-Head and Neck Surgery Foundation, Alexandria, Virginia, USA.

Objective: This update of a 2011 guideline developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation provides evidence-based recommendations on the pre-, intra-, and postoperative care and management of children 1 to 18 years of age under consideration for tonsillectomy. Tonsillectomy is defined as a surgical procedure performed with or without adenoidectomy that completely removes the tonsil, including its capsule, by dissecting the peritonsillar space between the tonsil capsule and the muscular wall. Tonsillectomy is one of the most common surgical procedures in the United States, with 289,000 ambulatory procedures performed annually in children <15 years of age based on the most recent published data. Read More

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http://dx.doi.org/10.1177/0194599818801757DOI Listing
February 2019
2 Reads

Utility of the Sleep Disorders Inventory for Students in Clinically Referred Youth With Insomnia: Risk Identification and Relationship With Polysomnographic Measures.

Behav Sleep Med 2019 Feb 22:1-13. Epub 2019 Feb 22.

a Division of Behavioral Medicine and Clinical Psychology/Pulmonary Medicine , Cincinnati Children's Hospital Medical Center , Cincinnati , Ohio.

Objective/background: This study evaluated the overall performance of the Sleep Disorders Inventory for Students (SDIS) in identifying sleep disorders risk and the sensitivity and specificity of specific SDIS subscales in a clinically referred sample of youth with insomnia.

Participants: Youth (N = 1,329, M = 2.5-18. Read More

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http://dx.doi.org/10.1080/15402002.2019.1578770DOI Listing
February 2019

Does care in a specialised stroke prevention clinic improve poststroke blood pressure control: a protocol for a randomised comparative effectiveness study.

BMJ Open 2019 Feb 19;9(2):e024695. Epub 2019 Feb 19.

Department of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.

Introduction: Hypertension is a major risk factor for recurrent stroke, and blood pressure (BP) reduction is associated with decreased risk of stroke recurrence. However, many stroke survivors have poorly controlled BP after their initial stroke. The Stroke Transitions Education and Prevention (STEP) Clinic was established to provide a comprehensive approach to stroke risk factor reduction. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02469
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http://dx.doi.org/10.1136/bmjopen-2018-024695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367992PMC
February 2019
12 Reads

Surgery for Obstructive Sleep Apnea in Obese Children: Literature Review and Meta-analysis.

Otolaryngol Head Neck Surg 2019 Feb 19:194599819829415. Epub 2019 Feb 19.

1 Department of Otolaryngology-Head and Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Objectives: Surgical intervention for obstructive sleep apnea (OSA) in overweight and obese children may not be as effective as it is in normal-weight children. The purpose of this study was to systematically review the effects of various surgical interventions for OSA in obese children and to meta-analyze the current data.

Data Sources: PubMed, OVID, and Cochrane databases. Read More

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http://dx.doi.org/10.1177/0194599819829415DOI Listing
February 2019
1 Read

Does drug induced sleep endoscopy-directed surgery improve polysomnography measures in children with Down Syndrome and obstructive sleep apnea?

Acta Otolaryngol 2018 Nov;138(11):1009-1013

c Pediatric Otolaryngology , Seattle Children's Hospital , Seattle , WA , USA.

Background: Children with Down Syndrome (DS) and obstructive sleep apnea (OSA) are difficult to treat, as first line therapies may not lead to significant improvement. Drug-induced sleep endoscopy (DISE) directed surgery may be particularly beneficial for these patients.

Objective: To assess change in polysomnography (PSG) measures of patients with DS who underwent DISE-directed surgery. Read More

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http://dx.doi.org/10.1080/00016489.2018.1504169DOI Listing
November 2018
1 Read

Safety and efficacy of a propofol and ketamine based procedural sedation protocol in children with cerebral palsy undergoing botulinum toxin A injections.

PM R 2019 Feb 13. Epub 2019 Feb 13.

Division of Pediatric Critical Care Medicine, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN.

Background: Pediatric patients with cerebral palsy (CP) often undergo intramuscular botulinum toxin (BoNT-A) injections. These injections can be painful and may require procedural sedation. An ideal sedation protocol has yet to be elucidated. Read More

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http://dx.doi.org/10.1002/pmrj.12146DOI Listing
February 2019
4 Reads

Assessment and treatment of pediatric obstructive sleep apnea in Canada: history and current state of affairs.

Authors:
Joanna E MacLean

Sleep Med 2019 Jan 23. Epub 2019 Jan 23.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Women & Children's Health Research Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada; Stollery Children's Hospital, Edmonton, Alberta, Canada. Electronic address:

Aim: To highlight Canada's contributions to the assessment and treatment of pediatric obstructive sleep apnea as well as outline the current state of pediatric obstructive sleep apnea in Canada.

Methods: A search was conducted in MEDLINE (Ovid) using Medical Subject Headings (MeSH) and free-text terms for 'child' and 'obstructive sleep apnea' with subsequent 'human' limit. The results were reviewed to identify publications where any author's listed a Canadian institution. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.011DOI Listing
January 2019
1 Read

The prevention of severe pertussis and pertussis deaths in young infants.

Authors:
James D Cherry

Expert Rev Vaccines 2019 Mar 22;18(3):205-208. Epub 2019 Feb 22.

a Department of Pediatrics , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Introduction: Today, in the developed world, virtually all deaths due to Bordetella pertussis illnesses occur in young infants. Areas Covered: Pertussis in young infants is characterized by an afebrile cough illness with coryza, apnea, seizures, cyanosis, and emesis. Severe illness is associated with high leukocyte and lymphocyte counts, rapid respiratory and cardiac rates and pneumonia. Read More

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
Publisher Site
http://dx.doi.org/10.1080/14760584.2019.1581065DOI Listing
March 2019
11 Reads

Preterm Infants May Better Tolerate Feeds at Temperatures Closer to Freshly Expressed Breast Milk: A Randomized Controlled Trial.

Breastfeed Med 2019 Apr 5;14(3):154-158. Epub 2019 Feb 5.

Division of Neonatology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.

Purpose: Feeding intolerance is one of the most frequent problems among preterm infants. These infants are fed with expressed breast milk or preterm formulas of which the temperature is not routinely measured. In this study, we aimed to examine the effects of feeds with warm milk versus room temperature milk in preterm infants. Read More

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http://dx.doi.org/10.1089/bfm.2018.0142DOI Listing
April 2019
2 Reads

Subjective and objective assessments of sleep problems in children with attention deficit/hyperactivity disorder and the effects of methylphenidate treatment.

Biomed J 2018 12 11;41(6):356-363. Epub 2019 Jan 11.

Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: to investigate the sleep problems in children with different ADHD presentations and effects of methylphenidate (MPH) on the sleep problems of children with ADHD by both subjective and objective measurements.

Methods: 71 children with ADHD and 30 controls were included. 35 had ADHD with predominantly inattentive presentation (ADHD-I) and 36 with predominantly hyperactive/impulsive or combined presentation (ADHD-C). Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362263PMC
December 2018
4 Reads

Sail sign in neonatal pneumomediastinum: a case report.

BMC Pediatr 2019 Jan 31;19(1):38. Epub 2019 Jan 31.

NSW Newborn & Paediatric Emergency Transport Service, Sydney, Australia.

Background: Pneumomediastinum is an uncommon cause of neonatal respiratory distress. Clinical history and examination of the neonate may be uninformative in determining the aetiology of the respiratory distress. Chest x-ray can be diagnostic of pneumomediastinum however is often difficult to interpret. Read More

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http://dx.doi.org/10.1186/s12887-019-1397-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354351PMC
January 2019
4 Reads

Polysomnographic characteristics of adolescents with asthma and low risk for sleep-disordered breathing.

Sleep Breath 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics, National Jewish Health, Denver, CO, USA.

Purpose: The aim of this study was to describe the polysomnographic characteristics of adolescents with asthma who are at low risk for sleep-disordered breathing (SDB) based on the Pediatric Sleep Questionnaire (PSQ).

Methods: Overnight polysomnography was performed on 85 adolescents with asthma and a score < 0.33 on the PSQ. Read More

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http://dx.doi.org/10.1007/s11325-018-01774-3DOI Listing
January 2019
2 Reads

Obstructive sleep apnea in children and adolescents with and without obesity.

Eur Arch Otorhinolaryngol 2019 Mar 28;276(3):871-878. Epub 2019 Jan 28.

Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Lykkebaekvej 1, 4600, Køge, Denmark.

Purpose: To investigate the prevalence of obstructive sleep apnea (OSA) in children referred for obesity treatment, and to compare the prevalence with that of a normal-weight group. Moreover, we examined the association between Body Mass Index Standard Deviation Score (BMI SDS) and the Apnea-Hypopnea Index (AHI).

Methods: This cross-sectional study included 139 children aged 7-18 years with overweight/obesity (BMI SDS >1. Read More

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http://link.springer.com/10.1007/s00405-019-05290-2
Publisher Site
http://dx.doi.org/10.1007/s00405-019-05290-2DOI Listing
March 2019
20 Reads