3,679 results match your criteria Pediatrics Apnea


Safety and efficacy of a propofol and ketamine based procedural sedation protocol in children with cerebral palsy undergoing botulinum toxin A injections.

PM R 2019 Feb 13. Epub 2019 Feb 13.

Division of Pediatric Critical Care Medicine, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN.

Background: Pediatric patients with cerebral palsy (CP) often undergo intramuscular botulinum toxin (BoNT-A) injections. These injections can be painful and may require procedural sedation. An ideal sedation protocol has yet to be elucidated. Read More

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http://dx.doi.org/10.1002/pmrj.12146DOI Listing
February 2019

Assessment and treatment of pediatric obstructive sleep apnea in Canada: history and current state of affairs.

Authors:
Joanna E MacLean

Sleep Med 2019 Jan 23. Epub 2019 Jan 23.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Women & Children's Health Research Institute, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada; Stollery Children's Hospital, Edmonton, Alberta, Canada. Electronic address:

Aim: To highlight Canada's contributions to the assessment and treatment of pediatric obstructive sleep apnea as well as outline the current state of pediatric obstructive sleep apnea in Canada.

Methods: A search was conducted in MEDLINE (Ovid) using Medical Subject Headings (MeSH) and free-text terms for 'child' and 'obstructive sleep apnea' with subsequent 'human' limit. The results were reviewed to identify publications where any author's listed a Canadian institution. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.011DOI Listing
January 2019
1 Read

The prevention of severe pertussis and pertussis deaths in young infants.

Authors:
James D Cherry

Expert Rev Vaccines 2019 Feb 8. Epub 2019 Feb 8.

a Department of Pediatrics , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Introduction: Today, in the developed world, virtually all deaths due to Bordetella pertussis illnesses occur in young infants. Therefore, it is important to discuss severe pertussis and its prevention. Areas Covered: These infant deaths are frequently misdiagnosed. Read More

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
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http://dx.doi.org/10.1080/14760584.2019.1581065DOI Listing
February 2019
4 Reads

Preterm Infants May Better Tolerate Feeds at Temperatures Closer to Freshly Expressed Breast Milk: A Randomized Controlled Trial.

Breastfeed Med 2019 Feb 5. Epub 2019 Feb 5.

Division of Neonatology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.

Purpose: Feeding intolerance is one of the most frequent problems among preterm infants. These infants are fed with expressed breast milk or preterm formulas of which the temperature is not routinely measured. In this study, we aimed to examine the effects of feeds with warm milk versus room temperature milk in preterm infants. Read More

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http://dx.doi.org/10.1089/bfm.2018.0142DOI Listing
February 2019
1 Read

Subjective and objective assessments of sleep problems in children with attention deficit/hyperactivity disorder and the effects of methylphenidate treatment.

Biomed J 2018 Dec 11;41(6):356-363. Epub 2019 Jan 11.

Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: to investigate the sleep problems in children with different ADHD presentations and effects of methylphenidate (MPH) on the sleep problems of children with ADHD by both subjective and objective measurements.

Methods: 71 children with ADHD and 30 controls were included. 35 had ADHD with predominantly inattentive presentation (ADHD-I) and 36 with predominantly hyperactive/impulsive or combined presentation (ADHD-C). Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362263PMC
December 2018
3 Reads

Sail sign in neonatal pneumomediastinum: a case report.

BMC Pediatr 2019 Jan 31;19(1):38. Epub 2019 Jan 31.

NSW Newborn & Paediatric Emergency Transport Service, Sydney, Australia.

Background: Pneumomediastinum is an uncommon cause of neonatal respiratory distress. Clinical history and examination of the neonate may be uninformative in determining the aetiology of the respiratory distress. Chest x-ray can be diagnostic of pneumomediastinum however is often difficult to interpret. Read More

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http://dx.doi.org/10.1186/s12887-019-1397-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354351PMC
January 2019
3 Reads

Polysomnographic characteristics of adolescents with asthma and low risk for sleep-disordered breathing.

Sleep Breath 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics, National Jewish Health, Denver, CO, USA.

Purpose: The aim of this study was to describe the polysomnographic characteristics of adolescents with asthma who are at low risk for sleep-disordered breathing (SDB) based on the Pediatric Sleep Questionnaire (PSQ).

Methods: Overnight polysomnography was performed on 85 adolescents with asthma and a score < 0.33 on the PSQ. Read More

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http://dx.doi.org/10.1007/s11325-018-01774-3DOI Listing
January 2019
1 Read

Obstructive sleep apnea in children and adolescents with and without obesity.

Eur Arch Otorhinolaryngol 2019 Jan 28. Epub 2019 Jan 28.

Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Lykkebaekvej 1, 4600, Køge, Denmark.

Purpose: To investigate the prevalence of obstructive sleep apnea (OSA) in children referred for obesity treatment, and to compare the prevalence with that of a normal-weight group. Moreover, we examined the association between Body Mass Index Standard Deviation Score (BMI SDS) and the Apnea-Hypopnea Index (AHI).

Methods: This cross-sectional study included 139 children aged 7-18 years with overweight/obesity (BMI SDS >1. Read More

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http://link.springer.com/10.1007/s00405-019-05290-2
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http://dx.doi.org/10.1007/s00405-019-05290-2DOI Listing
January 2019
11 Reads

Sleep-disordered breathing is common among term and near term infants in the NICU.

Pediatr Pulmonol 2019 Jan 27. Epub 2019 Jan 27.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

Objective: Among older infants and children, sleep-disordered breathing (SDB) has negative neurocognitive consequences. We evaluated the frequency and potential impact of SDB among newborns who require intensive care.

Study Design: Term and near-term newborns at risk for seizures underwent 12-h attended polysomnography in the neonatal intensive care unit (NICU). Read More

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http://dx.doi.org/10.1002/ppul.24266DOI Listing
January 2019
1 Read

Early sleep deprivation and attention-deficit/hyperactivity disorder.

Pediatr Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong.

Background: This study aims to study prospectively specific sleep patterns and risk of ADHD after adjusting for potential confounders such as obstructive sleep apnoea (OSA) and methylphenidate use.

Methods: A population-representative sample of 514 Chinese preschool children was recruited when in kindergarten (K3). Parents reported on their socioeconomic status and children's sleep duration. Read More

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http://www.nature.com/articles/s41390-019-0280-4
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http://dx.doi.org/10.1038/s41390-019-0280-4DOI Listing
January 2019
3 Reads

Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity.

Obesity (Silver Spring) 2019 Feb;27(2):190-204

Department of Medicine, Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.

A growing number of youth suffer from obesity and in particular severe obesity for which intensive lifestyle intervention does not adequately reduce excess adiposity. A treatment gap exists wherein effective treatment options for an adolescent with severe obesity include intensive lifestyle modification or metabolic and bariatric surgery while the application of obesity pharmacotherapy remains largely underutilized. These youth often present with numerous obesity-related comorbid diseases, including hypertension, dyslipidemia, prediabetes/type 2 diabetes, obstructive sleep apnea, nonalcoholic fatty liver disease, musculoskeletal problems, and psychosocial issues such as depression, anxiety, and social stigmatization. Read More

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http://doi.wiley.com/10.1002/oby.22385
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http://dx.doi.org/10.1002/oby.22385DOI Listing
February 2019
13 Reads

Paediatric intensive care admissions during the 2015-2016 Queensland human parechovirus outbreak.

J Paediatr Child Health 2019 Jan 24. Epub 2019 Jan 24.

Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Aim: The human parechovirus (HPeV) has emerged as a pathogen causing sepsis-like presentations in young infants, but there is a lack of data on HPeV presentations requiring intensive care support. We aimed to characterise the clinical presentation, disease severity, management and outcome of a population-based cohort of children with microbiologically confirmed HPeV infection requiring admission to paediatric intensive care units (PICUs) in Queensland, Australia during a recent outbreak.

Methods: This was a multicentre retrospective study of children admitted to PICU between 1 January 2015 and 31 December 2016 with confirmed HPeV infection. Read More

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http://doi.wiley.com/10.1111/jpc.14336
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http://dx.doi.org/10.1111/jpc.14336DOI Listing
January 2019
4 Reads

Nocturnal oximetry in children with obstructive lung disease or sleep-disordered breathing.

Pediatr Pulmonol 2019 Jan 22. Epub 2019 Jan 22.

Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.

Objectives: Although progress has been made in the standardized interpretation of nocturnal oximetry in children with obstructive sleep-disordered breathing (SDB), no evidence exists on oximetry abnormalities in other respiratory disorders. We aimed to compare obstructive lung disease (OLD) and SDB regarding nocturnal oximetry parameters.

Methods: We analyzed oximetry recordings from children with (i) OLD (obliterative bronchiolitis; cystic fibrosis); (ii) snoring and adenotonsillar hypertrophy (SDB); and (iii) no respiratory disorder (controls). Read More

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http://dx.doi.org/10.1002/ppul.24259DOI Listing
January 2019
4 Reads

Effect of Adenotonsillectomy on Ambulatory Blood Pressure in Pediatric Obstructive Sleep Apnea: 6-Month Follow-up Study.

Otolaryngol Head Neck Surg 2019 Jan 22:194599818825462. Epub 2019 Jan 22.

1 Department of Otolaryngology, National Taiwan University Hospital and Children's Hospital, Taipei, Taiwan.

Objective: To investigate 24-hour ambulatory blood pressure changes 6 months after surgery among children with obstructive sleep apnea.

Study Design: Prospective interventional study.

Setting: Tertiary medical hospital. Read More

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http://dx.doi.org/10.1177/0194599818825462DOI Listing
January 2019
5 Reads

Can standard deviation of overnight pulse oximetry be used to screen childhood obstructive sleep apnea.

Int J Pediatr Otorhinolaryngol 2019 Jan 7;119:27-31. Epub 2019 Jan 7.

Division of Pediatric Pulmonology, Department of Pediatrics, and Ramathibodi Hospital Sleep Disorder Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Objectives: Pulse oximetry (PO) has been frequently used as an alternative test to polysomnography (PSG) in children. We conducted this study to determine which statistical parameters obtained from overnight PO monitoring would be most suitable and to evaluate its diagnostic performance.

Methods: We prospectively recruited children with snoring referred for PSG. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.003DOI Listing
January 2019
2 Reads

Identifying Pathways Mediating Obstructive Sleep Apnea and Obesity in Indian Children.

Indian J Pediatr 2019 Jan 19;86(Suppl 1):15-19. Epub 2019 Jan 19.

Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Objective: Overweight and obesity in children is associated with several metabolic and cardiovascular impairments, including obstructive sleep apnea (OSA). However, the causal pathway from OSA to obesity is not fully known yet. The aim of this study was to explore the association between OSA and obesity-related metabolic outcomes in obese Indian children. Read More

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http://link.springer.com/10.1007/s12098-018-2828-4
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http://dx.doi.org/10.1007/s12098-018-2828-4DOI Listing
January 2019
5 Reads

Early-onset of symptoms and clinical course of Pompe disease associated with the c.-32-13 T > G variant.

Mol Genet Metab 2019 Feb 23;126(2):106-116. Epub 2018 Aug 23.

Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, 905 S. LaSalle street, GSRB1, Durham, NC, USA. Electronic address:

Background: Individuals with late-onset Pompe disease (LOPD) and the common c.-32-13 T > G variant are widely thought to have milder, adult-onset disease. This belief, and the consequent low suspicion of clinical involvement in children, has led to delays in diagnosis and treatment initiation in patients with early onset of symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183028
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http://dx.doi.org/10.1016/j.ymgme.2018.08.009DOI Listing
February 2019
8 Reads

Investigating the Sleep-Pain Relationship in Youth with Sickle Cell Utilizing mHealth Technology.

J Pediatr Psychol 2019 Jan 10. Epub 2019 Jan 10.

Department of Pediatrics, East Carolina University.

Objectives: The current study utilized mHealth technologies that were objective (e.g., sleep actigraphy and pulse oximetry) and time-sensitive (e. Read More

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http://dx.doi.org/10.1093/jpepsy/jsy105DOI Listing
January 2019
1 Read

Maxillary protraction to treat pediatric obstructive sleep apnea and maxillary retrusion: a preliminary report.

Sleep Med 2018 Dec 26. Epub 2018 Dec 26.

Division of Sleep Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.

Introduction: Midface retrusion creates a size deficiency problem in the upper airway that has been improved in children using surgical midface advancement and orthopedic protraction of the maxilla. The results of these treatments have been mostly promising at enlarging the pharyngeal airway. Recently introduced bone anchored maxillary protraction (BAMP) uses implant inserted devices in the jaws to pull the maxilla forward against a backward pressure to the lower jaw. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13899457183041
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http://dx.doi.org/10.1016/j.sleep.2018.12.005DOI Listing
December 2018
5 Reads

Polysomnography Findings and Sleep Disorders in Children With Alternating Hemiplegia of Childhood.

J Clin Sleep Med 2019 Jan 15;15(1):65-70. Epub 2019 Jan 15.

Division of Pediatric Neurology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

Study Objectives: Patients with alternating hemiplegia of childhood (AHC) experience bouts of hemiplegia and other paroxysmal spells that resolve during sleep. Patients often have multiple comorbidities that could negatively affect sleep, yet sleep quality and sleep pathology in AHC are not well characterized. This study aimed to report sleep data from both polysomnography (PSG) and clinical evaluations in children with AHC. Read More

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http://dx.doi.org/10.5664/jcsm.7572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329557PMC
January 2019
6 Reads

Mother Knows Best? Comparing Child Report and Parent Report of Sleep Parameters With Polysomnography.

J Clin Sleep Med 2019 Jan 15;15(1):111-117. Epub 2019 Jan 15.

Department of Medicine, University of Arizona, Tucson, Arizona.

Study Objectives: Parent report or child report is commonly used to obtain information on sleep in children. Data are lacking comparing the validity of parent-reported versus child-reported sleep parameters.

Methods: A total of 285 children (age 9 to 17 years) from the Tucson Children's Assessment of Sleep Apnea community cohort study were assessed. Read More

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http://dx.doi.org/10.5664/jcsm.7582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329554PMC
January 2019
2 Reads

Genotypic and phenotypic correlations of biotinidase deficiency in the Chinese population.

Orphanet J Rare Dis 2019 Jan 7;14(1). Epub 2019 Jan 7.

Department of Medical Genetics, National Taiwan University Hospital, No. 8, Chung-Shan S. Rd., Zhongzheng Dist., Taipei, 10041, Taiwan.

Biotinidase deficiency is an autosomal recessive disorder that affects the endogenous recycling and release of biotin from dietary protein. This disease was thought to be rare in East Asia. In this report, we delineate the phenotype of biotinidase deficiency in our cohort. Read More

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http://dx.doi.org/10.1186/s13023-018-0992-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323711PMC
January 2019
1 Read

Predictors of sleep hypoxemia in children with cystic fibrosis.

Pediatr Pulmonol 2019 Mar 4;54(3):273-279. Epub 2019 Jan 4.

Division of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Dallas, Texas.

Objectives: To identify the determinants of nocturnal hypoxemia in children with CF using clinical parameters, polysomnography (PSG), and lung function.

Hypothesis: Sleep hypoxemia in children with CF is predicted by both apnea hypopnea index (AHI) and percent predicted forced expiratory volume in one second (pFEV1).

Design: Retrospective case series. Read More

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http://doi.wiley.com/10.1002/ppul.24233
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http://dx.doi.org/10.1002/ppul.24233DOI Listing
March 2019
8 Reads

Successful Use of Quality Improvement Methodology to Reduce Inpatient Length of Stay in Bronchiolitis Through Judicious Use of Intermittent Pulse Oximetry.

Hosp Pediatr 2019 Feb 3;9(2):73-78. Epub 2019 Jan 3.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background And Objectives: The American Academy of Pediatrics 2014 bronchiolitis guidelines recommend against the routine use of continuous pulse oximetry (CPO) because it has been implicated in prolonging the length of stay (LOS). At our institution, infants admitted with bronchiolitis were monitored by using CPO during the entire hospital stay and intermittent desaturations <90% appeared to delay discharge. This quality improvement initiative was designed to reduce the LOS by decreasing the use of CPO in stable infants with nonsevere bronchiolitis. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0023DOI Listing
February 2019
4 Reads

Overnight oximetry as a screening tool for moderate to severe obstructive sleep apnoea in South African children.

S Afr Med J 2018 Dec 13;109(1):23-26. Epub 2018 Dec 13.

Division of Paediatric Pulmonology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Faculty of Health Sciences, University of Cape Town, South Africa.

Background: Obstructive sleep apnoea (OSA) is common in children yet often overlooked, as symptom-based screening is unreliable. Polysomnography is regarded as the gold standard for the diagnosis of OSA, but is not widely available in South Africa (SA). Overnight oximetry is a validated screening tool for OSA. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v109i1.13033DOI Listing
December 2018
5 Reads

Comparison of Physiological Performance of Four Adaptive Servo Ventilation Devices in Patients With Complex Sleep Apnea.

Am J Respir Crit Care Med 2019 Jan 3. Epub 2019 Jan 3.

Univiversity of Arizona and Southern Arizona VA Health Care System, Tucson, Arizona, United States ;

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http://dx.doi.org/10.1164/rccm.201807-1303LEDOI Listing
January 2019
2 Reads

The potential role of vascular alterations and subsequent impaired liver blood flow and hepatic hypoxia in the pathophysiology of non-alcoholic steatohepatitis.

Med Hypotheses 2019 Jan 22;122:188-197. Epub 2018 Nov 22.

Laboratory of Experimental Medicine and Paediatrics (LEMP), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disease ranging from steatosis to steatohepatitis (NASH) and fibrosis, but the underlying pathophysiological mechanisms remain largely unknown. As there is currently no approved pharmacological therapy and the prevalence of NAFLD keeps increasing, understanding of its pathophysiology is crucial. We hypothesise that vascular alterations in early NAFLD play a role in the progression of the disease by inducing an increased intrahepatic vascular resistance and consequently relative hypoxia in the liver. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183098
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http://dx.doi.org/10.1016/j.mehy.2018.11.014DOI Listing
January 2019
6 Reads

Critical care resources utilized in high-risk adenotonsillectomy patients.

Laryngoscope 2018 Dec 24. Epub 2018 Dec 24.

Division of Pediatric Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, U.S.A.

Objective: Children at high risk for respiratory complication after adenotonsillectomy are often admitted to a pediatric intensive care unit (PICU) postoperatively. Although many patients receive care in such units, it is unknown how many utilize critical care resources.

Methods: A review was conducted to audit intensive care needs of postadenotonsillectomy patients admitted to the PICU at a tertiary, academic, pediatric hospital between July 2013, and March 2017. Read More

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http://dx.doi.org/10.1002/lary.27623DOI Listing
December 2018
2 Reads

P-wave dispersion as a simple tool for screening childhood obstructive sleep apnea syndrome.

Sleep Med 2018 Nov 7;54:159-163. Epub 2018 Nov 7.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok, Thailand.

Introduction: The gold standard for the diagnosis of childhood obstructive sleep apnea syndrome (OSAS) diagnosis is polysomnography; however, electrocardiography (ECG) may provide a simpler alternative. P-wave dispersion (PWD), the difference between the maximum and minimum P-wave duration measured by 12-lead ECG, is increased in adult OSAS but has not been researched in childhood OSAS. The aims of this study were to determine the PWD and cut-off value for the diagnosis of childhood OSAS and its association with severity. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.032DOI Listing
November 2018
1 Read

Sleep and sleep disordered breathing in children with down syndrome: Effects on behaviour, neurocognition and the cardiovascular system.

Sleep Med Rev 2018 Nov 22;44:1-11. Epub 2018 Nov 22.

The Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University, Melbourne, Australia.

Down syndrome (DS), the most common human chromosomal malformation, has an estimated annual incidence of one in 1000 live births worldwide. Sleep problems are common in children with DS, reported by parents in up to 65% of school-aged children, significantly higher rates than in typically developing (TD) children. Problems include difficulty in sleep initiation and maintenance together with obstructive sleep apnoea (OSA) which affects up to over 90%, of DS children compared with 1-5% in the general paediatric population. Read More

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http://dx.doi.org/10.1016/j.smrv.2018.11.002DOI Listing
November 2018
2 Reads

Systematic review of hormonal and genetic factors involved in the nonsyndromic disorders of the lower jaw.

Dev Dyn 2019 Feb 9;248(2):162-172. Epub 2019 Jan 9.

Center for Craniofacial Research, Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas.

Mandibular disorders are among the most common birth defects in humans, yet the etiological factors are largely unknown. Most of the neonates affected by mandibular abnormalities have a sequence of secondary anomalies, including airway obstruction and feeding problems, that reduce the quality of life. In the event of lacking corrective surgeries, patients with mandibular congenital disorders suffer from additional lifelong problems such as sleep apnea and temporomandibular disorders, among others. Read More

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http://dx.doi.org/10.1002/dvdy.8DOI Listing
February 2019
1 Read

Polysomnography outcomes in children with small tonsils undergoing drug-induced sleep endoscopy-directed surgery.

Laryngoscope 2018 Dec 21. Epub 2018 Dec 21.

Department of Otolaryngology-Head and Neck Surgery, Seattle, Washington.

Objectives/hypothesis: The optimal surgical treatment to improve sleep apnea in children with small tonsils is not known. Drug-induced sleep endoscopy (DISE) may be useful in selecting effective surgical procedures for this patient population. This study compared polysomnography (PSG) measures before and after DISE-directed surgery in children with small tonsils. Read More

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http://dx.doi.org/10.1002/lary.27759DOI Listing
December 2018
3 Reads

Contributing factors of mortality in Prader-Willi syndrome.

Am J Med Genet A 2019 Feb 19;179(2):196-205. Epub 2018 Dec 19.

Department of Pediatrics, Division of Genetics and Genomics, University of California Irvine, Irvine, California.

Prader-Willi syndrome (PWS) is a multi-system disorder resulting from a lack of paternal gene expression in the 15q11.2-q13 region. Using databases compiled through response questionnaires completed by families known to the Prader-Willi Syndrome Association (USA), this study tested the hypothesis that PWS genetic subtype, BMI, age of diagnosis, clinical symptoms, and growth hormone treatment differ among deceased and living individuals with PWS. Read More

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http://doi.wiley.com/10.1002/ajmg.a.60688
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http://dx.doi.org/10.1002/ajmg.a.60688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349475PMC
February 2019
7 Reads

Perflubron Distribution During Transition From Gas to Total Liquid Ventilation.

Front Physiol 2018 30;9:1723. Epub 2018 Nov 30.

Departments of Pediatrics and Pharmacology/Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada.

Total liquid ventilation (TLV) using perfluorocarbons has shown promising results for the management of neonatal respiratory distress. However, one important safety consideration for TLV is a better understanding of the early events during the transition to TLV, especially regarding the fate of residual air in the non-dependent-lung regions. Our objective was to assess perflubron distribution during transition to TLV using electrical impedance tomography, complemented by fluoroscopy, in a neonatal lamb model of induced surfactant deficiency. Read More

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http://dx.doi.org/10.3389/fphys.2018.01723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283896PMC
November 2018
1 Read

The role of polysomnography in decannulation of children with brain and spinal cord injuries.

Pediatr Pulmonol 2019 Mar 11;54(3):333-341. Epub 2018 Dec 11.

Department of Pediatric Rehabilitation Medicine, Kennedy Krieger Institute, Baltimore, Maryland.

Objective: The objective of this retrospective review was to determine the utility of polysomnography (PSG) in influencing the decision to decannulate pediatric patients with brain and spinal cord injuries in an inpatient rehabilitation hospital setting.

Methods: Between 2010 and 2016, data were collected on pediatric patients with brain and/or spinal cord injuries who had PSG performed with the goal of decannulation. Patients underwent a decannulation protocol involving toleration of continuous tracheostomy capping and bedside tracheoscopy by otolaryngology. Read More

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http://dx.doi.org/10.1002/ppul.24208DOI Listing
March 2019
2 Reads

A pilot study of limb stimulation for the treatment of neonatal apnea.

Medicine (Baltimore) 2018 Dec;97(49):e12827

Department of Neonatology, Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, China.

This study explored the feasibility effect and safety of the limb stimulation (LS) for the treatment of neonatal apnea (NAP).The cases of 30 eligible premature infants with NAP were included in this retrospective study. These cases were equally divided into an intervention group (n = 15) and a control group (n = 15). Read More

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http://dx.doi.org/10.1097/MD.0000000000012827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310573PMC
December 2018

KCNQ2 mutation in an infant with encephalopathy of infancy with migrating focal seizures.

Epileptic Disord 2018 Dec;20(6):541-544

Department of Pediatrics (Neurology), McMaster University, 1280 Main St., W. Hamilton, Ontario L8S 4K1, Canada.

A male neonate presented with seizures at 18 hours of life, characterized by tonic posturing with eye deviation to the right, apnoea, bradycardia, and oxygen desaturation. Initial structural, metabolic, and infectious work-up was unremarkable. He continued to have seizures refractory to a variety of antiepileptic medications. Read More

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http://dx.doi.org/10.1684/epd.2018.1011DOI Listing
December 2018
1 Read

Intractable apnoeic seizures in a child with a deletion typically associated with Williams syndrome.

Epileptic Disord 2018 Dec;20(6):530-534

Division of Pediatric Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto.

Williams-Beuren syndrome is rarely associated with epilepsy. One previously reported case showed an association with apnoeic seizures while a few other cases showed an association with infantile epileptic spasms and generalized and focal seizures. We report the case of a 13-month-old boy with a deletion typically associated with Williams-Beuren syndrome, who presented with isolated apnoeic seizures which were refractory to multiple antiepileptic drugs but partially responsive to the ketogenic diet. Read More

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http://dx.doi.org/10.1684/epd.2018.1013DOI Listing
December 2018
6 Reads

Obstructive events in children with Prader-Willi syndrome occur predominantly during rapid eye movement sleep.

Sleep Med 2018 Oct 28;54:43-47. Epub 2018 Oct 28.

Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece. Electronic address:

Objective: Children with Prader-Willi syndrome (PWS) have a high prevalence of obstructive sleep apnea syndrome (OSAS). In most typically developing children with OSAS, more obstructive apneas and hypopneas occur during rapid eye movement (REM) than during non-REM (NREM) sleep. It was hypothesized that patients with PWS are even more prone to obstructive events in REM sleep than otherwise healthy subjects with OSAS. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.026DOI Listing
October 2018
1 Read

Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants.

Pediatrics 2019 Jan 5;143(1). Epub 2018 Dec 5.

Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background: Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes in preterm infants.

Methods: Infants of <29 weeks' gestation born between April 2009 and September 2011 and admitted to Canadian Neonatal Network units and then assessed at Canadian Neonatal Follow-up Network centers were studied. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1348DOI Listing
January 2019
38 Reads

Clinical Use of a Home Sleep Apnea Test: An Updated American Academy of Sleep Medicine Position Statement.

J Clin Sleep Med 2018 Dec 15;14(12):2075-2077. Epub 2018 Dec 15.

University of Michigan Sleep Disorders Center, University of Michigan, Ann Arbor, Michigan.

Abstract: The diagnosis and effective treatment of obstructive sleep apnea (OSA) in adults is an urgent health priority. It is the position of the American Academy of Sleep Medicine (AASM) that only a medical provider can diagnose medical conditions such as OSA and primary snoring. Throughout this statement, the term "medical provider" refers to a licensed physician and any other health care professional who is licensed to practice medicine in accordance with state licensing laws and regulations. Read More

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http://dx.doi.org/10.5664/jcsm.7540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287732PMC
December 2018
2 Reads
3.053 Impact Factor

The Accuracy of an Ambulatory Level III Sleep Study Compared to a Level I Sleep Study for the Diagnosis of Sleep-Disordered Breathing in Children With Neuromuscular Disease.

J Clin Sleep Med 2018 Dec 15;14(12):2013-2020. Epub 2018 Dec 15.

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Study Objectives: Polysomnography (PSG) surveillance recommendations are not being met for children with neuromuscular disease (NMD) because of limited diagnostic facilities. We evaluated the diagnostic accuracy of an ambulatory level III device as compared to a level I PSG.

Methods: A cross-sectional study was conducted at a tertiary pediatric institution. Read More

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http://dx.doi.org/10.5664/jcsm.7526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287726PMC
December 2018
2 Reads
3.053 Impact Factor

Potential Anatomic Markers of Obstructive Sleep Apnea in Prepubertal Children.

J Clin Sleep Med 2018 Dec 15;14(12):1979-1986. Epub 2018 Dec 15.

Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

Study Objectives: Adenotonsillar hypertrophy is the major cause of obstructive sleep apnea (OSA) in prepubertal children, but children without enlarged lymphoid tissues may still suffer from OSA. This study aimed to identify other potential anatomic features associated with childhood OSA.

Methods: This prospective study took place between January 2010 and April 2014. Read More

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http://dx.doi.org/10.5664/jcsm.7518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287721PMC
December 2018
9 Reads

Prothrombotic state in children with obstructive sleep apnea.

Sleep Med 2019 Jan 13;53:101-105. Epub 2018 Oct 13.

Institut d'Investigació Sanitària de les Illes Balears (IdISBa), Palma de Mallorca, Spain; CIBER Enfermedades Respiratorias (CibeRes) (CB06/06), Spain; Department of Respiratory Medicine, Hospital Universitari Son Espases, Palma de Mallorca, Spain.

Objective: Increased blood coagulation might be one important mechanism linking obstructive sleep apnea (OSA) with cardiovascular diseases. We tested the association between several hemostatic parameters and sleep breathing-related variables in a representative pediatric population with a clinical suspicion of OSA.

Methods: Polysomnography was performed in 152 snoring children to diagnose OSA. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.022DOI Listing
January 2019
1 Read

The impact of adenotonsillectomy on pediatric asthma.

Pediatr Pulmonol 2019 Jan 29;54(1):20-26. Epub 2018 Nov 29.

Research Division, State University of New York Downstate Medical Center, Brooklyn, New York.

Objective: To determine asthma outcomes in children undergoing adenotonsillectomy (T&A) for treatment of sleep-disordered breathing (SDB).

Hypothesis: Asthmatic children will demonstrate improvement in asthma control after T&A compared to asthmatic children not undergoing surgical treatment.

Study Design: Prospective cohort. Read More

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http://dx.doi.org/10.1002/ppul.24207DOI Listing
January 2019
2 Reads

Nocturnal enuresis in children is associated with differences in autonomic control.

Sleep 2018 Nov 26. Epub 2018 Nov 26.

Department of Pediatrics, Edmonton, Alberta, Canada.

Study Objectives: To assess the relationship between urine osmolality, cardiovascular parameters, and nocturnal enuresis in a population of children undergoing polysomnographic assessment.

Methods: This prospective observational study included consecutive children aged 5-17 years presenting for overnight polysomnography. Children were evaluated using continuous ambulatory blood pressure monitoring to assess heart rate and blood pressure. Read More

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http://dx.doi.org/10.1093/sleep/zsy239DOI Listing
November 2018
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Sleep-disordered breathing, craniofacial development, and neurodevelopment in premature infants: a 2-year follow-up study.

Sleep Med 2018 Oct 29. Epub 2018 Oct 29.

Stanford University Sleep Medicine Division, Stanford, CA, USA. Electronic address:

Introduction: Sleep problems, neuro-developmental development, and sleep-disordered-breathing (SDB), are reported as more prevalent in premature infants than in full-term infants. We investigated the relationship between neuro-development, and SDB in preterm infants at 24 months corrected age (CA) with a narrow palatal presentation over time.

Methods: We enrolled infants 40 weeks or younger at birth collecting obstetric and birth data. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.015DOI Listing
October 2018
2 Reads

Clinical cascades as a novel way to assess physical readiness of facilities for the care of small and sick neonates in Kenya and Uganda.

PLoS One 2018 21;13(11):e0207156. Epub 2018 Nov 21.

Institute of Global Health Sciences, University of California San Francisco, San Francisco, California, United States of America.

Background: Globally, there were 2.7 million neonatal deaths in 2015. Significant mortality reduction could be achieved by improving care in low- and middle-income countries (LMIC), where the majority of deaths occur. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207156PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248954PMC
November 2018
6 Reads
3.234 Impact Factor

Obstructive sleep disordered breathing in children - an important problem in the light of current European guidelines.

Otolaryngol Pol 2018 Jun;72(5):9-16

Medical Center in Ostrołęka, Branch in Różan.

Obstructive sleep-disordered breathing (SDB) is a common clinical problem. An unrecognized and untreated SDB is a serious threat for an intensively developing organism of a child. The consequences of SDB include cardiovascular and neurological complications, growth disorders and enuresis. Read More

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http://dx.doi.org/10.5604/01.3001.0012.1570DOI Listing
June 2018
10 Reads