4,123 results match your criteria Pediatrics Apnea


Isolated Central Hypothyroidism in an Adolescent With Narcolepsy.

Cureus 2020 Jun 7;12(6):e8496. Epub 2020 Jun 7.

Pediatric Endocrinology, State University of New York Downstate Medical Center, Brooklyn, USA.

Isolated central hypothyroidism (ICH) and narcolepsy are conditions rarely seen in the pediatric population which are usually characterized by delayed diagnosis and treatment due to their variable presentation and subclinical onset. We describe an unusual case of an adolescent male diagnosed with narcolepsy and central hypothyroidism. A 15-year-old obese boy presented with the complaint of excessive daytime sleepiness, fatigue, and snoring. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343299PMC

Aberrant DNA methylation levels of the 1/2/3 genes are associated with obstructive sleep apnea and its clinical phenotypes.

Am J Transl Res 2020 15;12(6):2521-2537. Epub 2020 Jun 15.

Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 83301, Taiwan.

Background: FPR1 over-expression and insufficiency of FPR2 and FPR3 are associated with disease severity of obstructive sleep apnea (OSA). We hypothesized that epigenetic modification of the genes may underlie intermittent hypoxia with re-oxygenation (IHR) injury in OSA.

Methods: DNA methylation levels over 17 CpG sites of the genes and their gene expression levels in the peripheral blood mononuclear cells were determined in 40 treatment-naïve OSA patients, 12 severe OSA patients under long-term continuous positive airway pressure treatment, 16 primary snoring (PS) subjects, and 10 healthy non-snorers (HS). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344102PMC

The efficacy of adenotonsillectomy on oxidative stress evaluated bythiol/disulfide balance.

Pediatr Int 2020 Jul 12. Epub 2020 Jul 12.

Ankara Yıldırım Beyazıt University, Atatürk Training and Research Hospital, Medical Biochemistry Department, Ankara, Turkey.

Background: Oxidative stress plays a role in the pathogenesis of many chronic diseases. Upper airway obstruction has been identified as a risk factor for increased oxidative stress-related disorders such as obstructive sleep apnea. The effect of adenotonsillar hypertrophywhich may result in a narrowing of the upper airways, on oxidative stress can be a valuablesubject of research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.14389DOI Listing

Successful containment of horizontal enterovirus infection in a neonatal unit in Singapore through diagnosis by polymerase chain reaction (PCR) and direct sequence analysis.

J Infect Public Health 2020 Jul 8. Epub 2020 Jul 8.

Department of Neonatology, KK Women's and Children's Hospital, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Lee Kong Chian School of Medicine, National Technological University, Singapore.

Background: Enterovirus (EV) outbreaks often coincide with seasonal peaks in the community. However, they may also sporadically occur in neonatal units. Identification of EV infection in neonates can be challenging, as they tend to present with mild or nonspecific symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiph.2020.06.029DOI Listing

A variable presentation of Joubert syndrome: Case report and a brief review.

J Neonatal Perinatal Med 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Metropolitan Hospital Center, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/NPM-180144DOI Listing

Transient Hypoxia Model Revealed Cerebrovascular Impairment in Anemia Using BOLD MRI and Near-Infrared Spectroscopy.

J Magn Reson Imaging 2020 Jul 9. Epub 2020 Jul 9.

Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.

Background: Obstructive sleep apnea and nocturnal oxygen desaturations, which are prevalent in sickle cell disease (SCD) and chronic anemia disorders, have been linked to risks of stroke and silent cerebral infarcts (SCI). Cerebrovascular response to intermittent desaturations has not been well studied and may identify patients at greatest risk.

Purpose: To investigate the cerebral dynamic response to induced desaturation in SCD patients with and without SCI, chronic anemia, and healthy subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmri.27210DOI Listing

Mechanisms of bradycardia in premature infants: Aerodigestive-cardiac regulatory-rhythm interactions.

Physiol Rep 2020 Jul;8(13):e14495

Innovative Neonatal and Infant Feeding Disorders Research Program, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

Objective: Eating difficulties coupled with cardiorespiratory spells delay acquisition of feeding milestones in convalescing neonates, and the mechanisms are unclear. Aims were to examine and compare the pharyngoesophageal-cardiorespiratory (PECR) response characteristics: (a) in control neonates and those with recurrent bradycardia spells; and (b) during pharyngeal stimulation when bradycardia occurs versus when no bradycardia occurs.

Methods: Preterm infants (N = 40, 27 ± 3 weeks gestation), underwent concurrent pharyngoesophageal manometry, electrocardiography, respiratory inductance plethysmography, and nasal airflow thermistor to evaluate pharyngoesophageal motility, heart rate (HR), and respiration during graded abrupt pharyngeal sterile water stimuli. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14814/phy2.14495DOI Listing

Variation in Car Seat Tolerance Screen Performance in Newborn Nurseries.

Pediatrics 2020 Jul 8. Epub 2020 Jul 8.

Division of Neonatology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: Currently, car seat tolerance screens (CSTSs) are recommended for all infants born prematurely in the United States. Although many late-preterm infants are cared for exclusively in newborn nurseries (NBNs), data on implementation of CSTS in nurseries are limited. Our objective for this study was to determine management strategies and potential variation in practice of CSTS in NBNs across the nation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2019-3593DOI Listing

Caffeine citrate maintenance doses effect on extubation and apnea post-ventilation in preterm infants.

Pediatr Pulmonol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatrics,, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, P.R. China.

Background: Caffeine citrate is used to prevent apnea in premature infants and help in extubation of invasive ventilation, but the optimal dose remains undetermined.

Methods: Neonates born at less than 30 weeks gestation who had received invasive ventilation for at least 48 hours and a loading dose of 20 mg/kg caffeine citrate, were randomly assigned into high (10 mg/kg daily) or low (5 mg/kg daily) maintenance dose groups. The drug was discontinued if no apnea occurred for seven consecutive days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24948DOI Listing

Altered slow-wave sleep activity in children with ROHHAD syndrome.

J Clin Sleep Med 2020 Jul 8. Epub 2020 Jul 8.

Sleep-Wake Disorders Unit, Soroka Medical Center, Beer-Sheva, Israel.

Study Objectives: Rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare condition. Little is known about sleep/wake and slow-wave activity (SWA) in this condition, although the central hypothalamic dysfunction associated with autonomic dysregulation would make the occurrence of SWA deregulation most likely.

Methods: Two children with clinical presentation of ROHHAD syndrome were evaluated, diagnosed, and treated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5664/jcsm.8678DOI Listing

Respiratory polygraphy data of children investigated for sleep-disordered breathing with different congenital or respiratory diseases.

Data Brief 2020 Aug 15;31:105859. Epub 2020 Jun 15.

Pediatric Pulmonology Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.

This short report describes respiratory indices of polygraphies (PG) performed to investigate several sleep-related disorders of breathing in children. It refers to the work of Michelet et al., Successful home respiratory polygraphy to investigate sleep-disordered breathing in children, Sleep Medicine [1]. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dib.2020.105859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327810PMC

Long Term Non-invasive Ventilation in Children With Central Hypoventilation.

Front Pediatr 2020 19;8:288. Epub 2020 Jun 19.

Pediatric Pulmonology & Regional Reference Centre for Pediatric Respiratory Failure and Cystic Fibrosis, Regina Margherita's Hospital, AOU Città della Salute e della Scienza, Turin, Italy.

Central hypoventilation (CH) is a quite rare disorder caused by some congenital or acquired conditions. It is featured by increased arterial concentration of serum carbon dioxide related to an impairment of respiratory drive. Patients affected by CH need to be treated by mechanical ventilation in order to achieve appropriate ventilation and oxygenation both in sleep and wakefulness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2020.00288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316889PMC

Inspiratory Muscle Training in Obstructive Sleep Apnea Associating Diabetic Peripheral Neuropathy: A Randomized Control Study.

Biomed Res Int 2020 12;2020:5036585. Epub 2020 Jun 12.

Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.

Objective: This work is aimed at assessing the effects of inspiratory muscle training on lung functions, inspiratory muscle strength, and aerobic capacity in diabetic peripheral neuropathy (DPN) patients with obstructive sleep apnea (OSA).

Methods: A randomized control study was performed on 55 patients diagnosed with DPN and OSA. They were assigned to the training group (IMT, = 28) and placebo training group (P-IMT, = 27). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/5036585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306097PMC

Nasogastric versus Orogastric Bolus Tube Feeding in Preterm Infants: Pilot Randomized Clinical Trial.

Am J Perinatol 2020 Jul 3. Epub 2020 Jul 3.

Neonatal Intensive Care Unit, Mansoura University Children's Hospital, Mansoura, Egypt.

Objective:  According to the most recent metanalysis, the best way to establish safe enteral feeding in preterm babies using nasogastric or orogastric tubes is still not well understood. This study aimed to determine the effects of bolus nasal tubes versus bolus orogastric tubes on the time required to reach full enteral feeding in preterm infants, as well as to compare the incidence rates of adverse events including nonintentional removal or displacement of the feeding tube, aspiration pneumonia/pneumonitis, apnea, necrotizing enterocolitis, gastric residual, and growth parameters between the studied cohort of preterm infants.

Study Design:  We conducted an unblinded pilot randomized clinical trial on hemodynamically stable preterm infants (>28 weeks) recruited from level 2 neonatal intensive care unit at Mansoura University Children's Hospital from June 2015 to May 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1713865DOI Listing

Machine learning for automatic identification of thoracoabdominal asynchrony in children.

Pediatr Res 2020 Jul 3. Epub 2020 Jul 3.

Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

Background: The current methods for assessment of thoracoabdominal asynchrony (TAA) require offline analysis on the part of physicians (respiratory inductance plethysmography (RIP)) or require experts for interpretation of the data (sleep apnea detection).

Methods: To assess synchrony between the thorax and abdomen, the movements of the two compartments during quiet breathing were measured using pneuRIP. Fifty-one recordings were obtained: 20 were used to train a machine-learning (ML) model with elastic-net regularization, and 31 were used to test the model's performance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-020-1032-1DOI Listing

Seizures in Pre-term Infants Less than 29 Weeks: Incidence, Etiology, and Response to Treatment.

Kans J Med 2020 25;13:134-142. Epub 2020 Jun 25.

Department of Pediatrics, University of Kansas School of Medicine-Wichita, KS.

Introduction: Seizures are neurological emergencies with short-and long-term adverse effects in pre-term infants. They may present with or without abnormal movements (clinical versus subclinical). Thus, the true incidence of seizures may be under-reported. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324056PMC

Differences in Anthropometric and Clinical Features among Preschoolers, School-Age Children, and Adolescents with Obstructive Sleep Apnea-A Hospital-Based Study in Taiwan.

Int J Environ Res Public Health 2020 Jun 29;17(13). Epub 2020 Jun 29.

Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan.

Pediatric obstructive sleep apnea (OSA) is associated with adverse health outcomes; however, little is known about the diversity of this population. This retrospective study aims to investigate age-related differences in the anthropometric and clinical features of this population. A total of 253 Taiwanese children (70 (27. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17134663DOI Listing

[Research progress on the predictive factors for the outcomes of adenotonsillectomy in children with obstructive sleep apnea syndrome].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jun;55(6):630-634

Department of Respiratory, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn115330-20191105-00666DOI Listing

Study protocol for the ACT response pilot intervention: development, implementation and evaluation of a systems-based Agitation Code Team (ACT) in the emergency department.

BMJ Open 2020 Jun 30;10(6):e036982. Epub 2020 Jun 30.

Department of Emergency Medicine, Yale University, New Haven, Connecticut, USA.

Introduction: Emergency department (ED) visits for behavioural conditions are rising, with 1.7 million associated episodes of patient agitation occurring annually in acute care settings. When de-escalation techniques fail during agitation management, patients are subject to use of physical restraints and sedatives, which are associated with up to 37% risk of hypotension, apnoea and physical injuries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2020-036982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328814PMC
June 2020
2.063 Impact Factor

Neonatal SCN2A encephalopathy: A peculiar recognizable electroclinical sequence.

Epilepsy Behav 2020 Jun 27;111:107187. Epub 2020 Jun 27.

Services d'explorations fonctionnelles, Centre de médecine du sommeil, Hôpital Antoine-Béclère, AP-HP, Clamart, France; Service de pédiatrie, Centre hospitalier intercommunal André Grégoire, Montreuil, France. Electronic address:

Introduction: Sodium voltage-gated channel alpha subunit 2 (SCN2A) gene encodes the Nav1.2 subunit of voltage-gated sodium channel in pyramidal neurons. SCN2A gain-of-function mutations are identified more and more often with gene panels and whole exome sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2020.107187DOI Listing

Apnoeic oxygenation in paediatric anaesthesia: a narrative review.

Authors:
C Lyons M Callaghan

Anaesthesia 2020 Jun 27. Epub 2020 Jun 27.

Department of Anaesthesia, Galway University Hospitals, Galway, Ireland.

Apnoeic oxygenation refers to oxygenation in the absence of any patient or ventilator effort to move the lungs. This phenomenon was first described in humans in the mid-20th century but has seen renewed interest in the last decade following the demonstration of apnoeic oxygenation with low-flow, and subsequently high-flow, nasal oxygen. This narrative review summarises our understanding of apnoeic oxygenation in the paediatric population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/anae.15107DOI Listing

The Mammalian Diving Response: Inroads to Its Neural Control.

Front Neurosci 2020 5;14:524. Epub 2020 Jun 5.

Department of Pharmacological and Physiological Science, School of Medicine, Saint Louis University, St. Louis, MO, United States.

The mammalian diving response (DR) is a remarkable behavior that was first formally studied by Laurence Irving and Per Scholander in the late 1930s. The DR is called such because it is most prominent in marine mammals such as seals, whales, and dolphins, but nevertheless is found in all mammals studied. It consists generally of breathing cessation (apnea), a dramatic slowing of heart rate (bradycardia), and an increase in peripheral vasoconstriction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2020.00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290049PMC

Caffeine prevents prostaglandin E1-induced disturbances in respiratory control in neonatal rats: implications for infants with critical congenital heart disease.

Am J Physiol Regul Integr Comp Physiol 2020 Jun 24. Epub 2020 Jun 24.

Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, United States.

Continuous infusion of prostaglandin E1 (PGE1) is used to maintain ductus arteriosus patency in infants with critical congenital heart disease, but it can also cause central apnea suggesting an effect on respiratory neural control. In this study, we investigated whether: 1) PGE1 inhibits the various phases of the acute hypoxic ventilatory response (HVR, an index of respiratory control dysfunction) and increases apnea incidence in neonatal rats; and 2) whether these changes would be reversible with caffeine pretreatment. Whole-body plethysmography was used to assess the HVR and apnea incidence in neonatal rats 2 hours following a single bolus intraperitoneal injection of PGE1 with and without prior caffeine treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00316.2019DOI Listing

Central Apnea of Prematurity: Does Sex Matter?

Am J Perinatol 2020 Jun 18. Epub 2020 Jun 18.

Department of Pediatrics, University of Virginia, Charlottesville, Virginia.

Objective:  Apnea is common among infants in the neonatal intensive care unit (NICU). Our group previously developed an automated algorithm to quantitate central apneas with associated bradycardia and desaturation (ABDs). Sex differences in lung disease are well described in preterm infants, but the influence of sex on apnea has not been established. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1713405DOI Listing

Prevalence of Sleep-Disordered Breathing in a Cohort of Adult Fontan Patients.

Pediatr Cardiol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pediatrics, Section of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA.

Sleep-disordered breathing (SDB) is described in patients with acquired heart failure but its prevalence in adults with congenital heart disease is not well documented. It is likely that single-ventricle patients who have undergone Fontan palliation poorly tolerate the additional stress of SDB on their fragile cardiac physiology. This study sought to determine the prevalence of SDB in a population of adult Fontan patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00246-020-02403-1DOI Listing

Symptoms of Daytime Sleepiness and Sleep Apnea among Pregnant Women.

Oman Med J 2020 May 21;35(3):e132. Epub 2020 Jun 21.

King Saud bin Abdulaziz University for Health Sciences, College of Medicine, Riyadh, Saudi Arabia.

Objectives: Despite the fact that sleep disturbances have been associated with poor maternal and neonatal health outcomes in pregnancy, no studies have assessed excessive daytime sleepiness or the risk for sleep apnea among pregnant Saudi Arabian women. We sought to estimate the prevalence of excessive daytime sleepiness (EDS) and the high risk for sleep apnea (OSA) in a sample of pregnant Saudi women.

Methods: An anonymous self-report questionnaire was completed by 517 pregnant women who attended obstetric outpatient clinics at King Abdulaziz Medical City, Riyadh, Saudi Arabia, for a routine pregnancy check. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5001/omj.2020.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306166PMC

Obstructive Sleep Apnea In a Lean Child with Type 1 Diabetes: Is It Linked to Diabetes?

Endocr Pract 2020 Jun;26(6):691

Division of Pediatric Endocrinology, Department of Pediatrics, Georgetown University, 4200 Wisconsin Avenue, Washington, DC 20016, E-mail: edu .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4158/1934-2403-26.6.691DOI Listing

Iatrogenic nasal synechiae in a premature newborn.

Turk J Pediatr 2020 ;62(3):505-508

Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: Nasal obstruction may cause short- and long-term problems such as respiratory distress, cyanosis, apnea, difficulty during feeding, and failure to thrive during the newborn period; since newborns are obligatory nasal breathers. Compression effect of the nasal cannulas and prongs used during respiratory support and nasal aspiration applications to clear the airways of secretions may result in nasal synechiae and acquired iatrogenic nasal obstruction.

Case: In this case report, we present a premature newborn with nasal synechiae secondary to long-term nasal continuous positive airway pressure (nasal CPAP) applications and routine upper airway nursing care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24953/turkjped.2020.03.023DOI Listing
January 2020

Copy number variation, gene expression and histological localization of human beta-defensin 2 in patients with adeno-tonsillar hypertrophy.

Biotech Histochem 2020 Jun 18:1-7. Epub 2020 Jun 18.

Department of Advance Diagnostics, Institute for Maternal and Child Health IRCCS Burlo Garofolo , Trieste, Italy.

Both bacterial infections and innate oral immunity response participate in development of adeno-tonsillar hypertrophy (ATH). ATH can lead to obstructive sleep apnea. We investigated the beta-defensin 2 (hBD-2) encoding gene, , by analyzing the copy number variations (CNVs) of the defensin gene cluster in patients with ATH and by correlating CNV with gene expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10520295.2020.1752936DOI Listing

A novel mutation in the gene c.3306dup; p.(Gln1103Thrfs*10) is associated to Weiss-Kruszka syndrome. A case report.

Acta Clin Belg 2020 Jun 16:1-4. Epub 2020 Jun 16.

Dept. of Pediatrics, Neurometabolism Unit, University Hospital Miguel Servet , Zaragoza, Spain.

Background Weiss-Kruszka syndrome (WSKA) is a rare disorder caused by mutations in the gene or deletion of 9p31.2 chromosome region, involving . The prevalence of WSKA is unknown as only 24 affected individuals have been described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17843286.2020.1780391DOI Listing

Profile of Retinopathy of Prematurity in Outborn and Inborn Babies at a Tertiary Eye Care Hospital.

Indian Pediatr 2020 Jun 12. Epub 2020 Jun 12.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Objectives: To study the profile of retinopathy of prematurity (ROP) among outborn and inborn babies at a tertiary-care centre.

Methodology: In a prospective observational study from 2015-2016, outborn and inborn babies eligible for ROP screening were evaluated for ROP profile and treatment results.

Results: 532 outborns and 38 inborns had ROP. Read More

View Article

Download full-text PDF

Source
June 2020
1.014 Impact Factor

Measures of nocturnal oxyhemoglobin desaturation in children with neuromuscular disease or Prader-Willi syndrome.

Pediatr Pulmonol 2020 Jun 11. Epub 2020 Jun 11.

Division of Pediatric Pulmonology and Sleep Disorders Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.

Objectives: Evidence for nocturnal oximetry interpretation in patients with abnormal neuromuscular function is limited. We aimed to compare children with neuromuscular disease (NMD) or Prader-Willi syndrome (PWS) to otherwise healthy subjects with obstructive sleep-disordered breathing (SDB) or without respiratory disorder (controls) regarding nocturnal oximetry parameters.

Methods: We analyzed recordings from children with: (a) NMD; (b) PWS; (c) snoring and adenotonsillar hypertrophy and/or obesity (SDB); and (d) controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24899DOI Listing

Subjective and polysomnographic evaluation of sleep in mitochondrial optic neuropathies.

J Sleep Res 2020 Jun 10:e13051. Epub 2020 Jun 10.

Department of Pediatrics and Adolescent Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Leber hereditary optic neuropathy and Dominant optic atrophy are associated with a selective loss of retinal ganglion cells (RGC). A subtype of RGC is responsible for light-dependent physiological processes. The aim of our study was to evaluate both subjective and objective sleep parameters in 36 (18 males; mean age 33. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jsr.13051DOI Listing

Psychosocial, behavioral and clinical correlates of children with overweight and obesity.

BMC Pediatr 2020 Jun 10;20(1):291. Epub 2020 Jun 10.

Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.

Background: Psychological and behavioral correlates are considered important in the development and persistence of obesity in both adults and youth. This study aimed to identify such features in youth with severe obesity (BMI ≥ 120% of 95percentile of sex-specific BMI-for-age) compared to those with overweight or non-severe obesity.

Methods: Youth with BMI ≥ 85 percentile were invited to participate in a prospective research registry where data was collected on attributes such as family characteristics, eating behaviors, dietary intake, physical activity, perception of health and mental well-being, and cardiometabolic parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-020-02145-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285533PMC
June 2020
1.918 Impact Factor

Interpreting CPAP device respiratory indices in children.

J Clin Sleep Med 2020 Jun 9. Epub 2020 Jun 9.

Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Australia.

Study Objectives: An increasing number of children with obstructive sleep apnea (OSA) require treatment with continuous positive airway pressure (CPAP). This study aimed to determine whether automatic respiratory indices from a CPAP device accurately predict manually determined respiratory indices derived from overnight polysomnography (PSG) in children.

Methods: Consecutive children undergoing manual CPAP titration PSG using a ResMed VPAP ST-A (S9) were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5664/jcsm.8618DOI Listing

Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway.

Respir Res 2020 Jun 8;21(1):140. Epub 2020 Jun 8.

Department of Pediatrics, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Zhejiang, Hangzhou, China.

Background: Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants and hyperoxia exposure is a major cause. In hyperoxic lung injury animal model, alveolar simplification and pro-inflammatory cells infiltration are the main pathophysiologic changes. Caffeine is a drug used to treat apnea in premature infants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-020-01403-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278162PMC

Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.

EBioMedicine 2020 Jun 5;56:102803. Epub 2020 Jun 5.

Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA.

Background: Sleep Disordered Breathing (SDB) is associated with a wide range of pathophysiological changes due, in part, to hypoxemia during sleep. We sought to identify gene transcription associations with measures of SDB and hypoxemia during sleep, and study their response to treatment.

Methods: In two discovery cohorts, Framingham Offspring Study (FOS; N = 571) and the Multi-Ethnic Study of Atherosclerosis (MESA; N = 580), we studied gene expression in peripheral blood mononuclear cells in association with three measures of SDB: Apnea Hypopnea Index (AHI); average oxyhemoglobin saturation (avgO2) during sleep; and minimum oxyhemoglobin saturation (minO2) during sleep. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2020.102803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276515PMC

Sleep surgery in syndromic and neurologically impaired children.

Am J Otolaryngol 2020 Jul - Aug;41(4):102566. Epub 2020 May 27.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, United States of America. Electronic address:

Purpose: To examine surgery performed for obstructive sleep apnea (OSA) in children with syndromic or neurologic comorbidities.

Material And Methods: Medical records of 375 children with OSA were retrospectively reviewed, including 142 patients with trisomy 21, 105 with cerebral palsy, 53 with muscular dystrophy, 32 with spinal muscular atrophy, 18 with mucopolysaccharidoses, 14 with achondroplasia, and 11 with Prader-Willi.

Outcome Measures: Apnea-hypopnea index (AHI), complications, length of postoperative stay, and endoscopic findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjoto.2020.102566DOI Listing

Posterior fossa subdural hematoma in a neonate with cleidocranial dysostosis after a spontaneous vaginal delivery: a case report.

Childs Nerv Syst 2020 Jun 5. Epub 2020 Jun 5.

Department of Neurosurgery, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.

Background: Cleidocranial dysostosis (CCD) is an anomaly characterized by delayed closure of the cranial sutures, midface hypoplasia, moderately short stature, hypoplastic or aplastic clavicles, dental abnormalities, and other complications.

Case Presentation: We report a case of posterior fossa subdural hematoma (PFSDH) after vaginal delivery in a neonate with CCD, which presented with several clinical symptoms such as apnea, vomiting, and bradycardia. Our patient, who had a family history of CCD, developed apnea and vomiting shortly after birth; PFSDH was detected by head computed tomography, and the patient recovered well following standard medical treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00381-020-04689-1DOI Listing

Can overnight portable pulse oximetry be used to stratify obstructive sleep apnea risk in infants? A correlation analysis.

Pediatr Pulmonol 2020 Jun 5. Epub 2020 Jun 5.

Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Introduction: There is limited evidence on the accuracy of oximetry in the evaluation of infant obstructive sleep apnea (OSA). We aimed to determine the utility of overnight oximetry to stratify infants at risk for OSA, to determine urgency for definitive screening with an overnight in-laboratory polysomnogram (PSG).

Methods: Retrospective single-institution cohort study of infants undergoing PSG and a separate overnight oximetry over an 8-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24887DOI Listing

Approach to the snoring child.

Singapore Med J 2020 Apr;61(4):170-175

Respiratory Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore.

Sleep is an important component in a child's growth and development. Snoring is common in children and often perceived as benign, but habitual snoring may be an indication of obstructive sleep apnoea (OSA). OSA can have health, developmental and cognitive consequences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11622/smedj.2020054DOI Listing

Pericardial Effusion/Cardiac Tamponade Induced by Peripherally Inserted Central Catheters in Very Low Birth Weight Infants: A Case Report and Literature Review.

Authors:
Ana Hou Jianhua Fu

Front Pediatr 2020 15;8:235. Epub 2020 May 15.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Although pericardial effusion/cardiac tamponade (PCE/CT) is a rare complication of peripherally inserted central catheters (PICCs), with an incidence of 0. 07-2%, it is associated with high mortality and is often life threatening. We sought to improve understanding of PICC-induced PCE/CT among pediatricians. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2020.00235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242726PMC

Treatment of superimposed preeclampsia on chronic hypertension in a twin pregnancy with automatic continuous positive airway pressure: a case report.

BMC Pulm Med 2020 Jun 3;20(1):157. Epub 2020 Jun 3.

Department of Obstetrics and Gynecology, CHA Bundang Medical Center, 59 Yatap-ro, Seongnam, 13496, Republic of Korea.

Background: Obstructive sleep apnoea (OSA) is related with adverse pregnancy outcomes, including preeclampsia. However, there are small studies about treatment of OSA with automatic continuous positive airway pressure (CPAP) in adverse obstetric outcomes.

Case Presentation: We introduce a case of 34 year old twin pregnant woman diagnosed with superimposed preeclampsia on chronic hypertension at 28 + 1/7 weeks of gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01196-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268687PMC

Respiratory Dysfunction and Sleep-Disordered Breathing in Children With Myasthenia Gravis.

J Child Neurol 2020 Aug 2;35(9):600-606. Epub 2020 Jun 2.

Department of Pediatrics, Division of Respirology, University of Toronto, Toronto, Ontario, Canada.

Objectives: The purpose of this study was to prospectively evaluate sleep patterns and the presence of sleep-disordered breathing in children with myasthenia gravis. We further aimed to examine the relationship between sleep and daytime respiratory function using spirometry tests including upright and supine forced vital capacity, sniff nasal inspiratory pressure, and maximal inspiratory pressure.

Methods: Eleven children between 3 and 18 years old with confirmed myasthenia gravis were recruited from The Hospital for Sick Children Neuromuscular Clinic in this prospective observational study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0883073820924213DOI Listing

Health Supervision for People With Achondroplasia.

Pediatrics 2020 Jun;145(6)

Department of Pediatrics, University of California, San Diego and Rady Children's Hospital, San Diego, California.

Achondroplasia is the most common short-stature skeletal dysplasia, additionally marked by rhizomelia, macrocephaly, midface hypoplasia, and normal cognition. Potential medical complications associated with achondroplasia include lower extremity long bone bowing, middle-ear dysfunction, obstructive sleep apnea, and, more rarely, cervicomedullary compression, hydrocephalus, thoracolumbar kyphosis, and central sleep apnea. This is the second revision to the original 1995 health supervision guidance from the American Academy of Pediatrics for caring for patients with achondroplasia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2020-1010DOI Listing

Age and Upper Airway Obstruction: A Challenge to the Clinical Approach in Pediatric Patients.

Int J Environ Res Public Health 2020 05 18;17(10). Epub 2020 May 18.

Division of Neonatology and Neonatal Intensive Care Unit, "F. Del Ponte" Hospital, 21100 Varese, Italy.

Upper airway abnormalities increase the risk of pediatric morbidity in infants. A multidisciplinary approach to obstructive sleep apnea syndrome (OSAS) poses challenges to clinical practice. The incidence and causes of OSA are poorly studied in children under 2 years of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17103531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277641PMC

NMDAR Encephalitis Associated With Acute Chikungunya Virus Infection: A New Trigger?

Front Pediatr 2020 30;8:176. Epub 2020 Apr 30.

Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil.

Anti-NMDAR encephalitis is the most frequent cause of autoimmune encephalitis. Chikungunya (CHIK) is an arbovirus responsible for outbreaks of fever, cutaneous rash and arthritis in underdeveloped countries, and a trigger for autoimmunity. We report a five-year-old male patient with fever, myalgia, headache and conjunctivitis for 5 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2020.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204150PMC

Apnea in preterm neonates: what's the role of gastroesophageal reflux? A systematic review.

Dig Liver Dis 2020 Jul 15;52(7):723-729. Epub 2020 May 15.

Pediatric Department, Ospedale "F. Del Ponte", University of Insubria, Varese, Italy.

A causal relationship between gastro-esophageal reflux (GER) and apnea in preterm infants has been frequently hypothesized and is currently debated. The present study aims at reviewing the currently available scientific evidence, in order to clarify the role of GER on the occurrence of apnea and to help improving the clinical management of apneic preterm neonates. We performed a systematic literature search to identify all the clinical studies on preterm neonates that properly assessed the relationship between apnea and GER. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dld.2020.03.032DOI Listing
July 2020
2.963 Impact Factor

Feasibility study of determining a risk assessment model for obstructive sleep apnea in children based on local findings and clinical indicators.

Int J Pediatr Otorhinolaryngol 2020 Aug 6;135:110081. Epub 2020 May 6.

Private Practice of Otorhinolaryngology, Split, Croatia.

Objective: To test a feasible and reliable model for diagnosing obstructive sleep apnea (OSA) in children, based on the clinically relevant parameters, in comparison to a polysomnography.

Methods: A total of 94 children with the suspected underlying OSA were included in the analyses. An association between clinical parameters (modified Mallampati score, tonsil size, adenoid size, age, gender, and body mass index) and apnea-hypopnea index (AHI) obtained following an overnight polysomnography was assessed, and significant variables were incorporated in the logistic regression model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2020.110081DOI Listing
August 2020
1.319 Impact Factor