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J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Allergy and Immunology, Department of Pediatrics, McGill University, Montreal, QC, Canada. Electronic address:

Background: This study focuses on side effects of cow's milk oral immunotherapy (CM-OIT) using consensus definitions of food-induced anaphylaxis.

Objective: To evaluate the risk of allergic reactions (ARs) and to identify risk factors associated with higher risk of anaphylactic ARs (AARs) during CM-OIT in children.

Methods: Clinical charts of children receiving CM-OIT were carefully reviewed. Read More

Pediatrics 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics, Nagasaki University Hospital, Nagasaki, Japan.

A 14-year-old girl developed 4 episodes of anaphylaxis of unknown etiology, which required intramuscular adrenaline administration each time. She had eaten pizza and a cheeseburger immediately before the first 2 episodes, respectively, but had not eaten anything for several hours before the last 2 episodes. It turned out that she had eaten the same ice lolly 4 hours before the first 3 episodes and a Café au lait Swirkle (a half-frozen beverage) 4 hours before the last episode. Read More

Clin Pediatr Endocrinol 2019 31;28(1):1-7. Epub 2019 Jan 31.

Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.

Congenital generalized lipodystrophy type 4 (CGL4) is a rare disease caused by mutations in the gene polymerase I and transcript release factor (), the main symptoms of which are systemic reductions in adipose tissue and muscular dystrophy. The strategy of treating CGL4 is to improve the insulin resistance and hypertriglyceridemia that result from systemic reductions in adipose tissue. Metreleptin, a synthetic analog of human leptin, is effective against generalized lipodystrophies; however, there are no reports of the use of metreleptin in the treatment of CGL4. Read More

Allergol Immunopathol (Madr) 2019 Feb 8. Epub 2019 Feb 8.

Division of Pediatric Allergy and Immunology, Kocaeli University Faculty of Medicine, Turkey. Electronic address:

Background: Limited studies conducted on children <2 years old and/or involving a skin prick test (SPT) for fresh milk (FM) have examined the predictive value of allergometric tests for outgrowth of cow's milk allergy (CMA). We investigated the optimal decision points for outgrowth (ODP) with SPT for commercial cow's milk extract (CE) and FM and specific immunoglobulin E (sIgE) levels for milk proteins to predict outgrowing allergy in children <2 years old.

Methods: SPTs for CE and FM, tests for sIgEs (cow's milk, casein, α-lactoalbumin, β-lactoglobulin) and oral food challenges (OFC) were performed in children referred for evaluation of suspected CMA, and 15 months after diagnosis. Read More

Asia Pac Allergy 2019 Jan 29;9(1):e1. Epub 2018 Oct 29.

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077.

Background: Peanut allergy is an increasing problem in Singapore and strict avoidance is difficult as peanut is ubiquitous in Asian cuisine.

Objective: We aimed to assess the efficacy and safety of peanut oral immunotherapy (OIT) in children with obvious peanut allergy in Singapore.

Methods: This was an open-label study of peanut OIT in children living in Singapore, with 2 weekly dose escalation until final maintenance dose of 3,000 mg of peanut protein and a maintenance phase of 12 months. Read More

J Allergy Clin Immunol Pract 2019 Feb 5. Epub 2019 Feb 5.

Division of Allergy and Immunology, University of Tennessee Health Science Center, Memphis, Tenn.

Infant anaphylaxis is an emerging risk, with food allergy the most common cause. Although the presentation of anaphylaxis involves the same systems as in older children and adults, there are real-world challenges to identifying symptoms of an allergic emergency in nonverbal children, as well as implementing optimal treatment. Recognition of anaphylaxis in infants can be challenging because allergic symptoms and certain normal infant behaviors may overlap. Read More

Allergol Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Pediatrics and Adolescent Medicine, Juntendo University, School of Medicine, Tokyo, Japan.

Background: Anaphylaxis is a severe and potentially fatal allergic response. Early-life exposure to rural environments may help protect against allergic reaction. This study assesses urban/rural differences by age and race/ethnicity in emergency department (ED) pediatric visit rates for food-induced anaphylaxis. Read More

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Geneva University Hospitals, Department of child and adolescent, Pediatric Allergy Unit, Geneva, Switzerland.

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Read More

J Allergy Clin Immunol Pract 2019 Feb;7(2):345-355.e2

Section of Allergy and Immunology, Children's Hospital Colorado, Food Challenge and Research Unit, University of Colorado School of Medicine, Aurora, Colo.

Peanut allergy is a growing public health concern in westernized countries. Peanut allergy is characterized as an often severe and lifelong allergy, which can have detrimental effects on quality of life and trigger anxiety. Although multiple therapeutic options are emerging, the focus of current management strategies is strict peanut avoidance and carriage of self-injectable epinephrine. Read More

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, 3052, Australia.

Background: Despite an increasing number of publications from individual countries and regions, there is still no systematic review of the global epidemiology of anaphylaxis in the general paediatric population.

Methods: We conducted a systematic review, using a protocol registered and published with the international prospective register of systematic reviews (PROSPERO). Results were reported following PRISMA guidelines. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14114

Division of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, Korea.

Anaphylaxis can cause death and requires immediate management. For prevention and education programs for anaphylaxis, it is important to be aware of the common triggering factors. We investigated the triggers of anaphylaxis in the emergency departments (EDs) of community hospitals in Korea. Read More

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

Division of Allergy Immunology and Dermatology, Department of Paediatrics, McGill University Health Centre, Montreal, Quebec, Canada.

Patent blue V dye (PBV) is frequently used as a perioperative drug for lymphangiography, as well as a food additive. Hypersensitivity to PBV is poorly documented in adults and had not been previously described in children. The diagnosis of PBV allergy depends on corroboration of history consistent with an IgE-mediated reaction and confirmatory skin tests. Read More

Ital J Pediatr 2019 Jan 14;45(1):13. Epub 2019 Jan 14.

Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy.

Background: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. Read More

Allergy 2019 Jan 12. Epub 2019 Jan 12.

Allergy Vigilance Network®, Vandoeuvre les Nancy, France.

Cleve Clin J Med 2019 01;86(1):66-72

Department of Medicine and Pediatrics, University of Tennessee College of Medicine, Memphis, TN, USA.

Patients who have had anaphylaxis or who are at risk of it (eg, due to food allergy or Hymenoptera hypersensitivity) should carry an epinephrine autoinjector at all times. However, the risks and benefits must be considered on an individual basis, especially in patients with atherosclerotic heart disease, elderly patients on polypharmacy, patients receiving allergen immunotherapy, those with large local reactions to insect stings, and individuals with oral allergy syndrome. Read More

Int Arch Allergy Immunol 2019 Jan 3:1-5. Epub 2019 Jan 3.

Department of Paediatrics, Allergy Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Introduction: Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity in a population of children with suspected HRs to this drug and their tolerance toward amoxi-cillin/clavulanic acid (AMX/CLV). Read More

Clin Exp Allergy 2018 Dec 31. Epub 2018 Dec 31.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.

Background: Mobile technology may help to better understand the adherence to treatment MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centered ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.

Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Read More

Pediatr Allergy Immunol 2018 Dec 27. Epub 2018 Dec 27.

CHU Lille, Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, F-59000, Lille, France.

Background: Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow-up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis.

Methods: We conducted a telephone survey of 166 children (≤18y) hospitalized from 2003 to 2013. Read More

J Allergy Clin Immunol Pract 2018 Dec 21. Epub 2018 Dec 21.

Department of Pediatrics, Section of Pediatric Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Department of Pediatrics, Section of Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, Texas. Electronic address:

Allergol Immunopathol (Madr) 2018 Dec 17. Epub 2018 Dec 17.

Allergy Unit, Pediatrics Area, Department of Woman and Child Health, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacre Hearth, Rome, Italy. Electronic address:

Background: Children with IgE-mediated cow's milk allergy (IgE-CMA) with gastrointestinal symptoms tolerate yogurt at 100%. Yogurt tolerance in children with IgE-CMA with urticaria and anaphylaxis was 7%.

Methods: We enrolled children with IgE-CMA with cutaneous, respiratory, gastrointestinal and anaphylactic symptoms. Read More

BMJ Case Rep 2018 Dec 14;11(1). Epub 2018 Dec 14.

Application Lab, R&D Department, Roxall Group, Bilbao, Spain.

We report a 10-year-old patient with haemophilia A developing anaphylaxis to recombinant factor VIII (octocog alfa). Allergic reactions, and especially anaphylactic events, are rare in patients with haemophilia A. The nature of these reactions is not fully understood. Read More

Immunity 2018 Dec;49(6):999-1001

Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

In allergic patients, small amounts of allergen activate mast cells and trigger an immune cascade that can result in anaphylactic shock. In a recent issue of Science, Choi et al. (2018) show that dendritic cells sample the lumen of blood vessels and use microvesicles to trigger mast cell degranulation and anaphylaxis. Read More

Allergy 2018 Dec 18. Epub 2018 Dec 18.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.

Pharmacists are trusted health professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact of allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. Read More

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.

Background: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; however, the epidemiology, mechanisms, and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.

Objective: Our objective was to better understand the mechanism, cross-reactivity, and scope of PEG hypersensitivity. Read More

Genet Med 2018 Dec 14. Epub 2018 Dec 14.

Departments of Molecular and Medical Genetics and Pediatrics, Oregon Health & Science University, Portland, OR, USA.

Purpose: Phenylketonuria (PKU) is a rare metabolic disorder that requires life-long management to reduce phenylalanine (Phe) concentrations within the recommended range. The availability of pegvaliase (PALYNZIQ™, an enzyme that can metabolize Phe) as a new therapy necessitates the provision of guidance for its use.

Methods: A Steering Committee comprising 17 health-care professionals with experience in using pegvaliase through the clinical development program drafted guidance statements during a series of face-to-face meetings. Read More

Hosp Pediatr 2019 Jan 12;9(1):16-23. Epub 2018 Dec 12.

Department of Pediatrics, Herman and Walter Samuelson Children's Hospital at Sinai, Baltimore, Maryland.

Background And Objectives: Anaphylaxis is rare but life-threatening. Its incidence during pediatric procedural sedation outside of the operating room is unknown. We used data from the Pediatric Sedation Research Consortium (PSRC) to determine the incidence and nature of allergic and anaphylactic reactions in this practice. Read More

Curr Treat Options Allergy 2018 1;5(4):436-444. Epub 2018 Oct 1.

2Erasmus Medical Center, Department of Internal Medicine, Section of Allergology, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Purpose Of Review: To describe and understand the links and interactions between food allergy and asthma.

Recent Findings: Food allergy and asthma are characterized by an increasing prevalence. Moreover, food allergy and asthma often coexist. Read More

J Paediatr Child Health 2019 Feb 6;55(2):143-151. Epub 2018 Dec 6.

Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Food allergy and anaphylaxis is increasing in Australian children, and anaphylaxis is relatively common in Australian schools. This review aims to provide an overview of current policies and practices for anaphylaxis management in Australian schools, including approaches to risk mitigation and anaphylaxis training. We reviewed literature related to anaphylaxis training in the school setting published between 2010 and 2018. Read More

J Investig Allergol Clin Immunol 2018 Dec;28(6):436-438

Erciyes University, School of Medicine, Department of Pediatrics, Division of Allergy, Kayseri, Turkey.

J Allergy Clin Immunol Pract 2018 Nov 23. Epub 2018 Nov 23.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada.

Background: Anaphylaxis due to unknown trigger (AUT) is anaphylaxis not explained by a proved or presumptive cause or stimulus at the time of the reaction. Research describing the management and follow-up of AUT is limited.

Objective: To assess and compare the demographic and clinical characteristics and the management of adult and pediatric AUT cases across Canada. Read More

J Allergy Clin Immunol Pract 2019 Feb 22;7(2):381-386. Epub 2018 Nov 22.

Department of Child and Adolescent, Medical School of the University of Geneva, University Hospitals of Geneva, Geneva, Switzerland.

Peanut is an allergenic legume that can cross-react with other plant-based foods, notably other legumes and tree nuts. Peanut-allergic individuals can be both cosensitized and coallergic to such items, requiring foresight when eliciting a clinical history of a reaction, in the diagnostic evaluation of such allergies, and in the counseling of patients as to food avoidances after a diagnosis is made. Legume allergens belong to the Fabaceae family and encompass the cupin, prolamin, PR-10, and lipid transfer protein families, which mediate cross-sensitization including that between peanut and tree nut. Read More

Turk Pediatri Ars 2018 Sep 1;53(3):149-154. Epub 2018 Sep 1.

Department of Pediatrics, Division of Pediatric Allergy and Asthma, Gazi University School of Medicine, Ankara, Turkey.

Aim: It has been shown by a great number of studies that the correct use of adrenaline auto injectors prescribed to patients with anaphylaxis is associated with the design of the auto injector, in addition to training. The aim of this study was to compare the skills of adults in using two different auto injectors prescribed to patients with anaphylaxis.

Material And Methods: Parents of patients aged between 1 and 18 years who referred to allergy outpatients were included in the study. Read More

Asian Pac J Allergy Immunol 2018 Oct 15. Epub 2018 Oct 15.

Samitivej Allergy Institute, Samitivej Thonburi Hospital, Thonburi, Bangkok, Thailand.

Background: The standard method for diagnosing immediate wheat allergy is oral food challenge test (OFC). However, OFC can provoke anaphylaxis during the challenge process. Skin prick test (SPT) using commercial wheat extract yielded unsatisfactory result for diagnosis of wheat allergy. Read More

Asian Pac J Allergy Immunol 2018 Oct 15. Epub 2018 Oct 15.

Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: The study of anaphylaxis in different geographic areas raises the awareness to improve prevention and medical care.

Objective: To investigate the incidence, causes, characteristics, and management of anaphylaxis in Chiang Mai, Thailand METHODS: We performed a retrospective review, based on ICD-10 electronic medical records of patients who attended the Out-Patient and Emergency Departments at Chiang Mai University Hospital from January 2007 to December 2016.

Results: A total of 441 episodes of anaphylaxis in 433 patients were analyzed. Read More

Arch Dis Child Educ Pract Ed 2018 Nov 15. Epub 2018 Nov 15.

Department of Paediatrics, Northumbria Healthcare NHS Foundation Trust, Newcastle, UK.

Am J Manag Care 2018 Oct;24(19 Suppl):S419-S427

Assistant Professor of Pediatrics and Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, TX. Email:

The management of peanut allergy involves strict avoidance, prompt recognition of allergic reactions, and rapid initiation of epinephrine and other supportive therapy for anaphylaxis. Avoidance presents several challenges and burdens to quality of life and daily activities. Currently, no treatment options are available for peanut allergy apart from epinephrine, which is the treatment of choice for severe allergic reactions. Read More

J Vis Exp 2018 10 25(140). Epub 2018 Oct 25.

Department of Chemistry, University of Alberta; Department of Medical Microbiology and Immunology, University of Alberta;

Antibody responses provide critical protective immunity to a wide array of pathogens. There remains a high interest in generating robust antibodies for vaccination as well as understand how pathogenic antibody responses develop in allergies and autoimmune disease. Generating robust antigen-specific antibody responses is not always trivial. Read More

J Allergy Clin Immunol 2018 Nov 9. Epub 2018 Nov 9.

Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

Ann Allergy Asthma Immunol 2019 Feb 7;122(2):189-192. Epub 2018 Nov 7.

Division of Allergy and Immunology, Department of Pediatrics, Elliot and Roslyn Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

Background: Diagnosis of almond allergy is complicated by a high rate of false-positive test results. Accurate diagnosis of almond allergy is critical because almond is a source of nutrition and milk products for children with other food allergies.

Objective: We reviewed the outpatient almond oral food challenges (OFCs) performed at our institution to analyze the pass rate and identify variables that predict OFC outcome. Read More

Allergy Asthma Clin Immunol 2018 3;14:79. Epub 2018 Nov 3.

1Division of Allergy & Immunology, Department of Pediatrics, University of British Columbia, British Columbia Children's Hospital, 4480 Oak St., Vancouver, BC V6H3N1 Canada.

Background: Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, (Korean or Asian ginseng), and (American ginseng). Although cases of allergy due to Korean ginseng have been reported in adults, there are no reported cases of allergy to American ginseng, and no reported cases of ginseng allergy in pediatric patients. Read More

Autoimmun Rev 2019 Jan 5;18(1):15-20. Epub 2018 Nov 5.

University of Toronto, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.

In recent years, the cross talk between the liver and the immune system is being uncovered, in part by studying liver involvement in primary immune deficiencies (PID) and in part by investigating the alterations of the immune system following orthotopic liver transplantation (OLT). Here we review some of the reciprocal interactions between the liver and the immune system. Patients with PID, particularly those involving inherited defects in T and B cells or innate immunity are prone to infections and inflammatory responses that often involve the liver. Read More

Asia Pac Allergy 2018 Oct 18;8(4):e37. Epub 2018 Oct 18.

Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba 261-0012, Japan.

Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication including tipepidine hibenzate, the patient presented with generalized erythema and urticaria, swollen face, coughing, wheezing and vomiting, together with hypotension and a decreased level of consciousness. Read More

Allergy 2018 Nov 5. Epub 2018 Nov 5.

Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: The preventive effect of allergen immunotherapy (AIT) on allergy and asthma development is currently assessed using primary and secondary AIT approaches. Knowledge of the immunological effects of these interventions is limited and the impact on epitope diversity remains to be defined.

Methods: We used high-density peptide arrays that included all known Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) allergens and the whole proteome of Der f to study changes in House Dust Mite (HDM) linear peptide recognition during a 2-year preventive double-blind placebo-controlled sublingual HDM AIT pilot study in 2-5-year-old children with sensitization to HDM but without symptoms. Read More

Allergy 2019 Jan 28;74(1):53-63. Epub 2018 Nov 28.

Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

Mast cells are typically linked to immediate hypersensitivity and anaphylaxis. This review looks beyond this narrow role, focusing on how these cells have evolved and diversified via natural selection promoting serine protease gene duplication, augmenting their innate host defense function against helminths and snake envenomation. Plasticity of mast cell genes has come at a price. Read More

J Allergy Clin Immunol 2019 Feb 30;143(2):651-661.e9. Epub 2018 Oct 30.

Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, Kravis Children's Hospital, New York, NY. Electronic address:

Background: Wheat is a common food allergen that can cause anaphylaxis.

Objective: We sought to determine the efficacy and safety of vital wheat gluten (VWG) oral immunotherapy (OIT).

Methods: After baseline double-blind, placebo-controlled food challenge (DBPCFC), 46 patients with wheat allergy (median age, 8. Read More

Clin Transl Allergy 2018 25;8:45. Epub 2018 Oct 25.

100Nova Southeastern University, Fort Lauderdale, Florida USA.

mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Read More

Allergy Asthma Clin Immunol 2018 29;14:64. Epub 2018 Oct 29.

3Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, 4480 Oak St, Rm 1C31B, Vancouver, BC V6H 3V4 Canada.

Background: Lupine is a member of the legume family and is often used in many food products in Europe (e.g. pasta, pizza, sauces, etc. Read More

J Allergy Clin Immunol Pract 2018 Oct 29. Epub 2018 Oct 29.

Division of Immunology, Boston Children's Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass. Electronic address:

Background: Acquired cold-induced urticaria (ACU) has not been well evaluated in pediatrics.

Objective: To further evaluate the presentation of ACU in children and associated risk of anaphylaxis.

Methods: A retrospective chart review was performed in children 18 years or younger diagnosed with ACU at Boston Children's Hospital (US, Northeast) from 1996 to 2017. Read More

Eur J Pediatr 2019 Feb 30;178(2):181-188. Epub 2018 Oct 30.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.

Cow's milk is one of the most common food allergens among children. Oral food challenge tests determine the threshold dose of allergens, but have not been standardized. To reduce the severe reactions, we developed a practical model of the test. Read More

Korean J Pediatr 2019 Feb 30;62(2):75-78. Epub 2018 Oct 30.

Department of Pediatrics, Kangwon National University Hospital, chuncheon, Korea.

Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g. Read More