1,732 results match your criteria Pediatrics Anaphylaxis


EAACI Biologicals Guidelines - Recommendations for severe asthma.

Allergy 2020 Jun 2. Epub 2020 Jun 2.

University of Wroclaw, Department of Clinical Immunology, Wroclaw, Poland.

Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, comorbidities, complexity in care pathways and differences between national or regional healthcare systems. Better understanding of the mechanisms has enabled a stratified approach to the management of severe asthma, supporting the use of targeted treatments with biologicals. Read More

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http://dx.doi.org/10.1111/all.14425DOI Listing

The need for improved transition and services for adolescent and young adult patients with allergy and asthma in all settings.

Allergy 2020 Jun 2. Epub 2020 Jun 2.

Asociación Española de Personas con Alergia a Alimentos y Látex, Madrid, Spain.

Adolescence is a challenging time for both patients and healthcare providers. Adolescent patients need to learn all the knowledge and skills required to competently and confidently self-manage their allergy and asthma. They have to negotiate the challenging transition from being children, whose medical care is supervised by their parents, to independent expert adult patients. Read More

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http://dx.doi.org/10.1111/all.14427DOI Listing

Seafood graded oral food challenge outcomes in a pediatric tertiary care center.

World Allergy Organ J 2020 May 13;13(5):100121. Epub 2020 May 13.

Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine in St. Louis, USA.

Background: There are sparse data regarding the predictors of positive oral food challenges and reaction severity for seafood in children.

Objective: Identify clinical characteristics in children with seafood allergy who were most likely to experience a negative oral food challenge (OFC).

Methods: A retrospective chart review was performed for children who had a graded OFC to seafood at a pediatric tertiary care center from 2008 through 2019. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248448PMC

Anaphylaxis related to disinfection with chlorhexidine in a teenager treated for cancer.

J Oncol Pharm Pract 2020 May 31:1078155220925531. Epub 2020 May 31.

Division of Pediatric Haemato-Oncology and Stem Cell Transplantation, Department of Pediatrics, Ghent University Hospital, Ghent, Belgium.

Introduction: Literature shows upcoming allergy to chlorhexidine due to the widespread use of the disinfectant within and outside surgical settings. Only a few case reports have been published regarding the use of topical chlorhexidine disinfectant outside surgery and only a minority of these within the pediatric population.

Case Report: We present a case-report of a teenager, treated for acute lymphoblastic leukemia who developed an anaphylactic shock after repeated chlorhexidine use for skin disinfection at the insertion of a central venous catheter during his chemotherapy treatment. Read More

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http://dx.doi.org/10.1177/1078155220925531DOI Listing

Poor asthma control remains a risk factor for severe anaphylaxis.

J Pediatr 2020 May 24. Epub 2020 May 24.

University of Trieste, Department of Pediatrics, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2020.05.045DOI Listing
May 2020
3.790 Impact Factor

Venom allergy and knowledge about anaphylaxis among beekeepers and their families.

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Immunology, Istanbul, Turkey.

Background: Beekeepers and their families are at an increased risk of life-threatening anaphylaxis due to recurrent bee-sting exposures.

Objective: The aim of this study is to evaluate the demographic features, previous history of anaphylaxis among beekeepers and their family members, and their knowledge about the symptoms and management of anaphylaxis.

Methods: A standardized questionnaire was administered to beekeepers during the 6th International Beekeeping and Pine Honey Congress held in 2018, in Mugla, Turkey. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.008DOI Listing

Food allergy: epidemiology, pathogenesis, diagnosis, prevention, and treatment.

Curr Opin Immunol 2020 May 19;66:57-64. Epub 2020 May 19.

Jaffe Food Allergy Institute, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Food allergy affects up to 10% of the population. The identification of modifiable risk factors including skin barrier dysfunction, vitamin D deficiency, microbiome, and route and timing of allergen exposure is leading to effective prevention strategies, and some of which are now included in public health guidelines. An increasing understanding of the pathophysiology has improved diagnostic options and revealed novel manifestations such as delayed anaphylaxis to mammalian meat related to sensitization to a sugar moiety triggered by tick bites. Read More

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http://dx.doi.org/10.1016/j.coi.2020.03.014DOI Listing

APPEAL-1: A pan-European survey of patient/caregiver perceptions of peanut allergy management.

Allergy 2020 May 21. Epub 2020 May 21.

Department of Allergy, Hospital Clínico San Carlos, Universidad Complutense de Madrid, IdISSC, ARADyAL, Madrid, Spain.

Background: Peanut allergy (PA) is associated with marked quality-of-life (QoL) impairment. However, data are lacking on the experience and impact of living with PA from the perspectives of persons with PA (PwPA) and their caregivers. Allergy to Peanuts imPacting Emotions And Life study 1 (APPEAL-1) was a pan-European survey investigating these perspectives. Read More

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http://dx.doi.org/10.1111/all.14414DOI Listing

Conversion from tacrolimus to sirolimus as a treatment modality in de novo allergies and immune-mediated disorders in pediatric liver transplant recipients.

Pediatr Transplant 2020 May 19:e13737. Epub 2020 May 19.

Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

De novo PTAID may develop in pediatric solid organ transplant recipients, have a diverse spectrum, and are occasionally treatment resistant. Previous reports showed resolution of immune cytopenias in solid organ transplant recipients following replacement of the calcineurin inhibitor tacrolimus with the mTOR inhibitor sirolimus. Herein we describe a retrospective review (2000-2017) of subjects who developed PTAID in whom immunosuppression was changed to sirolimus. Read More

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http://dx.doi.org/10.1111/petr.13737DOI Listing

Establishing Standardized Documentation for Anaphylaxis Treatment in a Tertiary Care Pediatric Allergy Clinic.

Pediatr Qual Saf 2020 Mar-Apr;5(2):e261. Epub 2020 Feb 15.

Division of Allergy and Immunology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio.

Introduction: Anaphylaxis is a potentially life-threatening allergic reaction. Common allergy clinic procedures, including oral food challenges and subcutaneous immunotherapy, carry a risk of anaphylaxis, the treatment for which is epinephrine. Our goal was to develop a standardized process for the management and documentation of allergic reactions that occur in a tertiary care pediatric allergy clinic. Read More

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http://dx.doi.org/10.1097/pq9.0000000000000261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190245PMC
February 2020

Health and Economic Outcomes of Home Maintenance Allergen Immunotherapy in Select Patients with High Health Literacy during the COVID-19 Pandemic: A Cost-Effectiveness Analysis During Exceptional Times.

J Allergy Clin Immunol Pract 2020 May 14. Epub 2020 May 14.

Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colo. Electronic address:

Background: Allergen immunotherapy (AIT) is safe and effective but is typically administered under strict clinic observation to mitigate the risk of a systemic reaction to immunotherapy (SRIT). However, in the setting of the global coronavirus disease 2019 pandemic, alternative care models should be explored.

Objective: To evaluate the cost-effectiveness of home immunotherapy self-administration (HITSA) in a highly idealized circumstance for provision of maintenance AIT in a shelter-in-place or other scenarios of unforeseen reduction in nonessential medical services. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224677PMC

A potential role of gliadin extract skin prick test in IgE-mediated wheat allergy.

Asian Pac J Allergy Immunol 2020 May 17. Epub 2020 May 17.

Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhonpathom, Thailand.

Background: Wheat extracts containing both water/salt and alcohol soluble proteins may increase extract's accuracy for diagnosing IgE-mediated wheat allergy.

Objective: This study aimed to determine the performance of new invented in-house prepared wheat extracts for skin prick test (SPT).

Methods: Children aged 1-18 years with history of immediate wheat allergy were recruited. Read More

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http://dx.doi.org/10.12932/AP-291119-0703DOI Listing

Patient characteristics of suspected mast-cell activation syndrome with sinonasal obstruction: a single institution experience.

Int Forum Allergy Rhinol 2020 May 14. Epub 2020 May 14.

Rick and Tina Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA.

Background: Mast-cell activation syndrome (MCAS) is increasingly recognized. Sinonasal obstruction is common among these patients. There is a paucity of literature describing the characteristics of MCAS and treatment outcomes. Read More

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http://dx.doi.org/10.1002/alr.22558DOI Listing

Pollen-food allergy syndrome in children.

Authors:
You Hoon Jeon

Clin Exp Pediatr 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Pollen-food allergy syndrome (PFAS) is an immunoglobulin E-mediated immediate allergic reaction caused by cross-reactivity between pollen and the antigens of foods-such as fruits, vegetables, or nuts-in patients with pollen allergy. A 42.7% prevalence of PFAS in Korean pediatric patients with pollinosis was recently reported. Read More

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http://dx.doi.org/10.3345/cep.2019.00780DOI Listing

APPEAL-1: A multiple country European survey assessing the psychosocial impact of peanut allergy.

Allergy 2020 May 13. Epub 2020 May 13.

Department of Paediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London, and Guy's and St, Thomas' NHS Foundation Trust, London, UK.

Background: Peanut allergy (PA) is a common, potentially life-threatening, and typically lifelong condition with a significant burden of illness. However, information is lacking on how persons with PA (PwPA) and their caregivers perceive the psychosocial impact of living with PA. The Allergy to Peanuts imPacting Emotions And Life study 1 (APPEAL-1) survey, conducted across Europe, investigated the experience and impact of living with PA. Read More

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http://dx.doi.org/10.1111/all.14363DOI Listing

Combined Effects of and Egg Oral Immunotherapy in a Mouse Model of Egg Allergy.

Allergy Asthma Immunol Res 2020 Jul;12(4):701-711

Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, Korea.

Purpose: Recent clinical trials have successfully used oral immunotherapy (OIT) to treat food allergies. Probiotics have immunomodulatory effects by balancing Th1/Th2 immunity and enhancing regulatory T-cell activity. In this study, we analyzed the effects of OIT, probiotics alone, and probiotics administered simultaneously with OIT in a mouse model of egg allergy. Read More

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http://dx.doi.org/10.4168/aair.2020.12.4.701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225004PMC

Preventing food allergy in infancy and childhood: systematic review of randomised controlled trials.

Pediatr Allergy Immunol 2020 May 12. Epub 2020 May 12.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: This systematic review of ways to prevent immediate-onset/IgE-mediated food allergy will inform guidelines by the European Academy of Allergy and Immunology (EAACI).

Methods: The GRADE approach was used. Eleven databases were searched from 1946 to October 2019 for randomised controlled trials (and large prospective cohort studies in the case of breastfeeding). Read More

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http://dx.doi.org/10.1111/pai.13273DOI Listing

Anaphylaxis to MMR Vaccine Mediated by IgE Sensitivity to Gelatin.

Mil Med 2020 May 12. Epub 2020 May 12.

Allergy and Immunology, Wilford Hall Medical Center, 59th Medical Group, 2200 Bergquist Drive Lackland Air Force Base, San Antonio, TX 78236.

The measles-mumps-rubella (MMR) vaccine is generally well tolerated, and reports of anaphylaxis to the vaccine are rare. IgE-mediated reactions to vaccines are often caused by additives or residual vaccine components. An inability to obtain proper immunizations can be a disqualifying component to military service. Read More

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http://dx.doi.org/10.1093/milmed/usaa058DOI Listing

Anaphylaxis as a presenting symptom of food allergy in children with no known food allergy.

J Allergy Clin Immunol Pract 2020 Apr 26. Epub 2020 Apr 26.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.jaip.2020.04.033DOI Listing

Food allergy 2020: learning from the past, looking to the future.

Ann Allergy Asthma Immunol 2020 05;124(5):409-410

Department of Pediatrics, Allergy and Immunology, New York University Langone Health, New York, New York; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180025PMC

Clinical and in vitro cross-reactivity of cereal grains in children with IgE-mediated wheat allergy.

Allergol Immunopathol (Madr) 2020 Apr 20. Epub 2020 Apr 20.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Introduction And Objectives: Wheat and cereal grains have a broad range of cross-reactivity, but the clinical relevance of this cross-reactivity is uncertain. This study aimed to evaluate clinical and in vitro cross-reactivity with barley, oat, and Job's tears among wheat-allergic patients.

Materials And Methods: Patients aged 5 to 15 years with IgE-mediated wheat allergy were enrolled. Read More

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http://dx.doi.org/10.1016/j.aller.2019.11.008DOI Listing

Acute At Home Management of Anaphylaxis During the Covid-19 Pandemic.

J Allergy Clin Immunol Pract 2020 Apr 18. Epub 2020 Apr 18.

Allergy and Immunology, Department of Pediatrics, Hassenfeld Children's Hospital, New York University School of Medicine, New York, NY; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.

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http://dx.doi.org/10.1016/j.jaip.2020.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166008PMC

In-vivo diagnostic test allergens in Europe: A call to action and proposal for recovery plan - An EAACI position paper.

Allergy 2020 Apr 19. Epub 2020 Apr 19.

Allergy Section, Department of Internal Medicine, Hospital Valld'Hebron, 08035, Barcelona, Spain.

Diagnostic allergens are defined as medicinal products in the EU. Marketing authorization by national authorities is necessary, howeverdiagnostic allergensare not homogeneously regulated in different EU member states. Allergen manufacturers argue with increasing costs forcing them to continuously reduce the diagnostic allergen portfolios offeredto allergists. Read More

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http://dx.doi.org/10.1111/all.14329DOI Listing

Peanut Allergy: New Advances and Ongoing Controversies.

Pediatrics 2020 May 17;145(5). Epub 2020 Apr 17.

Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Peanut allergy is one of the most common food allergies in children, with increasing prevalence over time. The dual-allergen exposure hypothesis now supports transcutaneous sensitization to peanut as a likely pathophysiologic mechanism for peanut allergy development. As a result, there is emerging evidence that early peanut introduction has a role in peanut allergy prevention. Read More

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http://dx.doi.org/10.1542/peds.2019-2102DOI Listing

Prehospital Treatment and Emergency Department Outcomes in Young Children with Food Allergy.

J Allergy Clin Immunol Pract 2020 Apr 14. Epub 2020 Apr 14.

Permanente Medical Group, Department of Emergency Medicine, Kaiser Permanente Oakland Medical Center, Oakland, Calif.

Background: Studies assessing food-induced allergic reactions and prehospital treatments in infants and young children are scarce.

Objective: To describe differences in clinical characteristics in children aged 0 to 4 years presenting to the emergency department (ED) with food allergy (FA) reactions and investigate the association between prehospital epinephrine use and clinical outcomes.

Methods: Retrospective cohort study of FA ED visits in Kaiser Permanente Northern California from January 2016 to December 2018. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.03.047DOI Listing

An adolescent girl with signs and symptoms of anaphylaxis and negative immunologic workup: a case report.

J Med Case Rep 2020 Apr 17;14(1):49. Epub 2020 Apr 17.

Department of Psychiatry, University of California San Diego, San Diego, CA, 92121, USA.

Background: The increasing incidence of allergies and allergic reactions among children and adults has become a major public health concern. The etiology of allergic reactions can often be confirmed based on a detailed history and supportive testing. However, there are cases where the underlying factors are more complex and difficult to identify. Read More

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http://dx.doi.org/10.1186/s13256-020-02371-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164209PMC

Achieving the Quadruple Aim to deliver value-based allergy care in an ever-evolving health care system.

Ann Allergy Asthma Immunol 2020 Apr 11. Epub 2020 Apr 11.

Section of Allergy and Immunology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Departments of Pediatrics, Medicine, and Community and Family Medicine, Dartmouth Geisel School of Medicine, Hanover, New Hampshire. Electronic address:

Objective: To define the concept of value-based care in allergy, and to review challenges and opportunities in value-based health care delivery for allergists and immunologists.

Data Sources: Articles describing practice variation, health care financing and reimbursement, shared decision-making, cost-effective health care delivery, patient-reported outcome measures, social determinants of health, and screening.

Study Selections: A narrative review detailing concepts and approaches to improve value-based health care in the context of the Quadruple Aim to address the patient and physician experience, cost, and population health. Read More

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http://dx.doi.org/10.1016/j.anai.2020.04.007DOI Listing

GENDER AND OCCUPATIONAL ALLERGY (GOA): Report from the task force of the EAACI Environmental & Occupational Allergy Interest Group.

Allergy 2020 Apr 12. Epub 2020 Apr 12.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bochum, Germany.

Women's work has traditionally been considered less hazardous to health in comparison with men's work. The increased women's participation in the workforce has led to an increased attention to women's working conditions. Women and men are unequally represented in individual professions or sectors (horizontal segregation), with women also under-represented in leadership positions (vertical segregation). Read More

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http://dx.doi.org/10.1111/all.14317DOI Listing

The state of vaccine safety science: systematic reviews of the evidence.

Lancet Infect Dis 2020 May 9;20(5):e80-e89. Epub 2020 Apr 9.

Department of International Health, Johns Hopkins University, Baltimore, MD, USA; Institute of Vaccine Safety, Johns Hopkins University, Baltimore, MD, USA; Department of Health, Behavior & Society, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

This Review updates the scientific evidence assessing possible causal associations of adverse events following immunisation (AEFI) compiled in the 2012 report from the Institute of Medicine and the 2014 report from the Agency for Healthcare Research and Quality. For 12 of 46 AEFI examined, a causal relationship has been established with at least one vaccine currently routinely recommended to the general USA population: anaphylaxis, arthralgia or arthritis (mild, acute, and transient, not chronic), deltoid bursitis (when vaccine is administered improperly), disseminated varicella infection (in immune deficient individuals for whom the varicella vaccine is contraindicated), encephalitis, febrile seizures, Guillain-Barré syndrome, hepatitis (in immune deficient individuals for whom the varicella vaccine is contraindicated), herpes zoster, immune thrombocytopenic purpura, meningitis, and syncope. Other than mild acute and transient arthralgia or arthritis, which is very common in adult women after rubella vaccine, these adverse reactions are rare or very rare. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30130-4DOI Listing

Epinephrine in the Management of Anaphylaxis.

J Allergy Clin Immunol Pract 2020 Apr;8(4):1186-1195

Division of Immunology, Department of Pediatrics, Harvard Medical School, Boston, Mass; Boston Children's Hospital, Boston, Mass.

Epinephrine is life-saving and the only first-line medication in the management of anaphylaxis. At therapeutic doses, it acts rapidly to reverse nearly all symptoms of anaphylaxis, and stabilize mast cells. The standard approved doses administered intramuscularly in the lateral thigh have a long track record for safe and effective use, but more information is needed on epinephrine pharmacokinetics and pharmacodynamics to ensure that current dosing strategies are optimal. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.12.015DOI Listing

Diagnostic Challenges in Anaphylaxis.

J Allergy Clin Immunol Pract 2020 Apr;8(4):1177-1184

Department of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY.

Anaphylaxis is a severe and potentially life-threatening allergic reaction. Since its discovery over 100 years ago, research has led to great strides in describing pathophysiologic mechanisms of anaphylaxis; however, there is still imprecision regarding its definition and a lack of reliable, confirmatory testing. In this paper, we review definitions of anaphylaxis, highlighting studies examining the utility of the current clinical consensus definition. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.11.003DOI Listing

Microfluidic methods for precision diagnostics in food allergy.

Biomicrofluidics 2020 Mar 3;14(2):021503. Epub 2020 Apr 3.

Department of Mechanical Engineering, Stanford University, Stanford, California 94305, USA.

Food allergy has reached epidemic proportions and has become a significant source of healthcare burden. Oral food challenge, the gold standard for food allergy assessment, often is not performed because it places the patient at risk of developing anaphylaxis. However, conventional alternative food allergy tests lack a sufficient predictive value. Read More

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http://dx.doi.org/10.1063/1.5144135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127910PMC

T follicular regulatory cells and IL-10 promote food antigen-specific IgE.

J Clin Invest 2020 Apr 7. Epub 2020 Apr 7.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States of America.

Food allergies are a major clinical problem and are driven by IgE antibodies specific for food antigens. T follicular regulatory (TFR) cells are a specialized subset of Foxp3+ T cells that modulate antibody responses. Here we analyzed the role of TFR cells in regulating antigen-specific IgE using a peanut-based food allergy model in mice. Read More

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http://dx.doi.org/10.1172/JCI132249DOI Listing
April 2020
13.215 Impact Factor

Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis.

Asian Pac J Allergy Immunol 2020 Mar 29. Epub 2020 Mar 29.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: The number of children presenting with IgE-mediated wheat reactions to academic medical centers in Thailand continues to increase.

Objective: Improved knowledge about the clinical characteristic of wheat allergy is urgently needed to better understand the risk factors and to improve proper treatment in this patient population.

Methods: A cross-sectional study using questionnaire review of children who presented with IgE-mediated wheat allergy during 2001 to 2015 was performed. Read More

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http://dx.doi.org/10.12932/AP-130919-0645DOI Listing

Rates of anaphylaxis for the most common food allergies.

J Allergy Clin Immunol Pract 2020 Mar 31. Epub 2020 Mar 31.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.jaip.2020.03.014DOI Listing

Peanut applied to the skin of nonhuman primates induces antigen-specific IgG but not IgE.

Immun Inflamm Dis 2020 Jun 27;8(2):211-215. Epub 2020 Mar 27.

Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Introduction: Previous studies in humans support the dual-allergen exposure hypothesis, and several studies in mouse models have demonstrated that cutaneous exposure to disrupted or intact skin can lead to sensitization to peanut. However, the field lacks definitive evidence that cutaneous exposure leads to peanut allergy in humans or other primates.

Methods: Peanut extract was applied to the shaved back of the neck of four male and four female African green monkeys three times per week for 4 weeks. Read More

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http://dx.doi.org/10.1002/iid3.296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212195PMC

MALT1 Protease Plays a Dual Role in the Allergic Response by Acting in Both Mast Cells and Endothelial Cells.

J Immunol 2020 May 25;204(9):2337-2348. Epub 2020 Mar 25.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224;

The signaling protein MALT1 plays a key role in promoting NF-κB activation in Ag-stimulated lymphocytes. In this capacity, MALT1 has two functions, acting as a scaffolding protein and as a substrate-specific protease. MALT1 is also required for NF-κB-dependent induction of proinflammatory cytokines after FcεR1 stimulation in mast cells, implicating a role in allergy. Read More

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http://dx.doi.org/10.4049/jimmunol.1900281DOI Listing

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.

J Exp Med 2020 Jun;217(6)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Paris, France.

Autosomal dominant hyper-IgE syndrome (AD-HIES) is typically caused by dominant-negative (DN) STAT3 mutations. Patients suffer from cold staphylococcal lesions and mucocutaneous candidiasis, severe allergy, and skeletal abnormalities. We report 12 patients from 8 unrelated kindreds with AD-HIES due to DN IL6ST mutations. Read More

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http://dx.doi.org/10.1084/jem.20191804DOI Listing
June 2020
12.515 Impact Factor

Making the GRADE in anaphylaxis management: Toward recommendations integrating values, preferences, context, and shared decision making.

Ann Allergy Asthma Immunol 2020 Jun 19;124(6):526-535.e2. Epub 2020 Mar 19.

Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective: To review GRADE (Grading of Recommendations Assessment, Development, and Evaluation) methods and discuss the clinical application of conditional recommendations in clinical guidelines, specifically in the context of anaphylaxis.

Data Sources: Articles that described GRADE, evidence synthesis, evidence to recommendation frameworks, and shared decision making were used to discuss conditional recommendations of the 2020 Anaphylaxis GRADE guideline.

Study Selections: A narrative review detailing concepts of GRADE and approaches to translate conditional recommendations to individualized and contextualized patient care. Read More

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http://dx.doi.org/10.1016/j.anai.2020.03.009DOI Listing

Erratum: Correction for affiliation of 3rd author Randomized comparison of caregivers' ability to use epinephrine autoinjectors and prefilled syringes for anaphylaxis.

Authors:

Asian Pac J Allergy Immunol 2020 03;38(1):67

Corrected affiliation of 3rd author Pediatric Allergy & Clinical Immunology Research Unit, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand. Read More

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Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice.

J Allergy Clin Immunol 2020 Mar 16. Epub 2020 Mar 16.

Department of Pediatrics, Boston Children's Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass. Electronic address:

Background: Patients with eosinophilic esophagitis have increased numbers of mucosal mast cells. Administration of the proton pump inhibitor omeprazole can reduce both esophageal mast cell and eosinophil numbers and attenuate type 2 inflammation in these subjects.

Objective: Given that maintenance of an acidic environment within granules is important for mast cell homeostasis, we sought to evaluate the effects of omeprazole on mast cell functions including development, IgE:FcεRI-mediated activation, and responses to food allergen. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.02.032DOI Listing

Characteristics and Treatment of Anaphylaxis in Children Visiting a Pediatric Emergency Department in Korea.

Biomed Res Int 2020 27;2020:2014104. Epub 2020 Feb 27.

Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University, Gyeonggi-do, Republic of Korea.

Anaphylaxis is a serious life-threatening allergic disease in children. This study is aimed at determining the characteristics of pediatric patients who experienced anaphylaxis along with treatments administered in order to determine the usefulness of tryptase level assessment as a marker of anaphylaxis in Korean children. A total of 107 patients who were diagnosed with anaphylaxis in a single pediatric emergency center over a 3-year period were included in the study. Read More

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http://dx.doi.org/10.1155/2020/2014104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064841PMC
February 2020

Hooked epinephrine auto-injector devices in children: four case reports with three different proposed mechanisms.

Allergy Asthma Clin Immunol 2020 14;16:19. Epub 2020 Mar 14.

3Division of Pediatric Emergency Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA USA.

Background: The prevalence of epinephrine auto-injectors (EAI) use is on the rise. Our objective was to describes children with hooked EAI needles that were embedded in soft tissues.

Case Presentation: Results: Two children self-injected in their shins. Read More

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http://dx.doi.org/10.1186/s13223-020-00418-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071737PMC

Biologicals in atopic disease in pregnancy: an EAACI position paper.

Allergy 2020 Mar 18. Epub 2020 Mar 18.

Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Departments of Paediatrics and Immunology, University of Toronto, Toronto, ON, Canada.

Biologicals have transformed the management of severe disease phenotypes in asthma, atopic dermatitis, and chronic spontaneous urticaria. As a result, the number of approved biologicals for the treatment of atopic diseases is continuously increasing. Although atopic diseases are among the most common diseases in the reproductive age, investigations, and information on half-life, pharmacokinetics defining the neonatal Fc receptors (FcRn) and most important safety of biologicals in pregnancy are lacking. Read More

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http://dx.doi.org/10.1111/all.14282DOI Listing
March 2020
6.028 Impact Factor

Transfer and loss of allergen-specific responses via stem cell transplantation: a prospective observational study.

Allergy 2020 Mar 17. Epub 2020 Mar 17.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: Currently, no estimates can be made on the impact of hematopoietic stem cell transplantation on allergy transfer or cure of the disease. By using component-resolved diagnosis we prospectively investigated fifty donor-recipient pairs undergoing allogeneic stem cell transplantation. This allowed calculating the rate of transfer or maintenance of allergen-specific responses in the context of stem cell transplantation. Read More

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http://dx.doi.org/10.1111/all.14278DOI Listing

Successful desensitization of Pegvaliase (Palynziq®) in a patient with phenylketonuria.

Mol Genet Metab Rep 2020 Jun 6;23:100575. Epub 2020 Mar 6.

Department of Human Genetics, Emory University, School of Medicine, Atlanta, GA, United States of America.

Pegvaliase (Palynziq®) was FDA approved in 2018 as an enzyme substitution therapy in patients with Phenylketonuria. However, various drug induced hypersensitivity adverse events (HAEs) have been reported. We present a case of Pegvaliase (Palynziq®) induced anaphylaxis and successful desensitization. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2020.100575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063228PMC

Shellfish allergy is a risk factor for cricket anaphylaxis.

J Allergy Clin Immunol Pract 2020 Mar 12. Epub 2020 Mar 12.

Division of Clinical Immunology and Allergy, Department of Medicine, St Michael's Hospital, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.02.039DOI Listing