1,502 results match your criteria Pediatrics Anaphylaxis


Anaphylaxis after wheat ingestion in a patient with coeliac disease: two kinds of reactions and the same culprit food.

Eur J Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

In recent years, the role of atopic dermatitis epidermal skin barrier defects in inducing a transcutaneous allergic sensitization is highly debated, possibly explaining why some children with eczema are sensitized to foods they have never eaten. In our specific situation, the association between coeliac disease and wheat allergy might be particularly harmful owing to unavoidable strict food avoidance. We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001421DOI Listing
April 2019
2 Reads

Analysis of allergens in corn-dependent exercise-induced anaphylaxis.

Ann Allergy Asthma Immunol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Fujita Health University General Allergy Center, Nagoya, Japan.

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http://dx.doi.org/10.1016/j.anai.2019.04.005DOI Listing
April 2019
1 Read

Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies.

Allergy Asthma Clin Immunol 2019 29;15:19. Epub 2019 Mar 29.

1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of dual latex and chlorhexidine allergies which caused anaphylaxis after pelvic examination in a woman with a history of latex-related fruits allergy. Read More

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http://dx.doi.org/10.1186/s13223-019-0335-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441184PMC
March 2019
2 Reads

Analysis of Oral Food Challenge Outcomes in IgE-mediated Food Allergies to Almond in a Large Cohort.

J Allergy Clin Immunol Pract 2019 Apr 8. Epub 2019 Apr 8.

Massachusetts General Hospital for Children, Food Allergy Center, Department of Pediatrics, Massachusetts General Hospital, Boston, MA.

Background: While almond-specific IgE-mediated food allergies have traditionally been equated with other tree nut allergies, outcomes of oral food challenges to almond and the utility of clinical testing to predict IgE-mediated almond hypersensitivity is not well known.

Objective: To describe almond oral challenge outcomes and assess the predictive value of clinical testing.

Methods: 603 almond challenges performed for 590 patients, aged 1 to 66 years, were analyzed from Massachusetts General Hospital allergy practices. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.03.049DOI Listing
April 2019
2 Reads

Safety and Efficacy of Buccal Dexmedetomidine for MRI Sedation in School-Aged Children.

Hosp Pediatr 2019 Apr 10. Epub 2019 Apr 10.

Departments of Pediatrics and.

Objectives: Intranasal, intramuscular, and intravenous (IV) dexmedetomidine routes have been used successfully for pediatric MRI studies. We designed this retrospective study to determine efficacy and safety of buccal dexmedetomidine for pediatric MRI sedation.

Methods: Medical records were reviewed of outpatient children ages 5 to 18 years who received buccal dexmedetomidine with or without oral midazolam for MRI sedation at a freestanding children's hospital sedation program in 2015 and 2016. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0162DOI Listing
April 2019
1 Read

Safety of Oral and Intravenous Iron.

Acta Haematol 2019 Apr 10;142(1):8-12. Epub 2019 Apr 10.

Division of Hematology/Medical Oncology, Department of Pathology and Pediatrics, Oregon Health and Science University, Portland, Oregon, USA,

As the adverse effects of iron deficiency are better recognized, the use of oral and intravenous iron has increased dramatically. Oral iron is often poorly tolerated, with up to 70% or more of patients noting gastrointestinal issues; this may affect adherence to therapy. In addition, many patients will not respond to oral iron due to their underlying illness. Read More

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http://dx.doi.org/10.1159/000496966DOI Listing
April 2019
1 Read

Mobile technology offers novel insights on control and treatment of allergic rhinitis. The MASK study.

J Allergy Clin Immunol 2019 Apr 2. Epub 2019 Apr 2.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France; Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France; INSERM U 1168, VIMA : Ageing and chronic diseases Epidemiological and public health approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France and Euforea, Brussels, Belgium. Electronic address:

Background: Mobile health may be used to generate innovative insights into optimizing treatment to improve allergic rhinitis control.

Objectives: A cross-sectional real world observational study was undertaken in 22 countries to complement a pilot study and bring novel information on medication use, disease control and work productivity in everyday life of patients with allergic rhinitis.

Methods: A mobile phone app (Allergy Diary, freely available Google Play and Apple stores) was used to collect data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all allergy medications (prescribed and over-the-counter (OTC)) customized for 22 countries. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.053DOI Listing
April 2019
8 Reads
11.476 Impact Factor

Can sIgE Levels to Food Allergens Predict Food-induced Anaphylaxis in Infants?

Authors:
Young Yoo

J Korean Med Sci 2019 Apr 8;34(13):e109. Epub 2019 Apr 8.

Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3346/jkms.2019.34.e109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449599PMC
April 2019
2 Reads

Infantile Anaphylaxis in Korea: a Multicenter Retrospective Case Study.

J Korean Med Sci 2019 Apr 8;34(13):e106. Epub 2019 Apr 8.

Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Background: Anaphylaxis is increasing in young children. The aim of the present study was to analyze the clinical characteristics of anaphylaxis in Korean infants, with a focus on food triggers.

Methods: The study analyzed the medical records of infants aged 0 to 2 years old who had been diagnosed with anaphylaxis in 23 secondary or tertiary hospitals in Korea. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449600PMC
April 2019
1 Read

An update on allergic emergencies.

Curr Opin Pediatr 2019 Apr 1. Epub 2019 Apr 1.

The Geisel School of Medicine at Dartmouth, Hanover.

Purpose Of Review: To provide an updated framework of management for allergic emergencies.

Recent Findings: The most frequent causes of anaphylaxis include medications, foods, and stinging insects. Early and appropriate administration of epinephrine is critical to managing anaphylaxis. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000769DOI Listing
April 2019
1 Read

Rocuronium anaphylaxis in a 7-year-old boy during the induction of anesthesia.

Immunol Med 2018 Jun 30;41(2):85-88. Epub 2018 Jul 30.

a Department of Pediatrics , JCHO Kyoto Kuramaguchi Medical Center , Kyoto , Japan.

We report a case of rocuronium-induced anaphylaxis in a previously healthy 7-year-old boy. The first presenting sign of anaphylaxis was bronchospasm, appearing 11 min after he received intravenous doses of rocuronium (1 mg/kg) (Eslax, MSD Co. Ltd. Read More

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http://dx.doi.org/10.1080/13497413.2018.1481580DOI Listing
June 2018
4 Reads

The Efficacy of Antivenin Latrodectus (Black Widow) Equine Immune F(ab') Versus Placebo in the Treatment of Latrodectism: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.

Ann Emerg Med 2019 Mar 26. Epub 2019 Mar 26.

Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO.

Study Objective: The antivenom currently available for treatment of systemic black widow envenomation (latrodectism) is composed of equine whole immunoglobin. Although considered effective, it has been associated with anaphylaxis and 2 reported fatalities. We test the efficacy and safety of new equine antivenom composed of purified F(ab') antibody fragments. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2019.02.007DOI Listing
March 2019
1 Read
4.676 Impact Factor

Alpha-gal phenotypes- lessons from various patient populations.

Ann Allergy Asthma Immunol 2019 Mar 25. Epub 2019 Mar 25.

Division of Allergy & Clinical Immunology, University of Virginia, Charlottesville, VA.

Galactose alpha-1,3-galactose (alpha-gal) is a carbohydrate epitope found on proteins and lipids in non-primate mammals and present in foods (particularly organ or fat-rich red meat) and medications, where it causes delayed onset and immediate onset anaphylaxis respectively. Several species of ticks contain alpha-gal epitopes and possibly salivary adjuvants that promote high titre sensitisation and clinical reactivity. Risk factors for alpha-gal syndrome include exposure to ticks of particular species. Read More

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http://dx.doi.org/10.1016/j.anai.2019.03.021DOI Listing
March 2019
2 Reads

Health-related quality of life in children and adolescents after systemic sting reaction.

Ann Agric Environ Med 2019 Mar 19;26(1):103-108. Epub 2018 Sep 19.

Department of Paediatrics, Jagiellonian University Medical College, Krakow, Poland.

Introduction And Objectives: Insect stings are the second trigger of anaphylaxis in children and adolescents, causing a potentially life-threatening reactions. Hence health-related quality of life (HRQoL) is an important issue for Hymenoptera venom allergy (HVA) patients. The aim of this cross-sectional study was to evaluate the impact of HVA on young patients' HRQoL, including their socio-demographic characteristics. Read More

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http://dx.doi.org/10.26444/aaem/93747DOI Listing

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma.

Clin Transl Allergy 2019 11;9:16. Epub 2019 Mar 11.

115Nova Southeastern University, Fort Lauderdale, FL USA.

Aims: Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases.

Methods: MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. Read More

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http://dx.doi.org/10.1186/s13601-019-0252-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413444PMC
March 2019
1 Read

National School Nurse Survey of Food Allergy and Anaphylaxis Policies and Education.

J Allergy Clin Immunol Pract 2019 Mar 22. Epub 2019 Mar 22.

Division of Allergy and Immunology, Department of Pediatrics, The Elliot and Roslyn Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1016/j.jaip.2019.03.013DOI Listing

Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses.

Int Arch Allergy Immunol 2019 Mar 20:1-7. Epub 2019 Mar 20.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria,

Peanut allergy is considered to be the most common cause for food-induced anaphylaxis. Currently, no approved treatment is available. Avoidance is the only measure to prevent anaphylactic reactions to peanuts. Read More

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http://dx.doi.org/10.1159/000496438DOI Listing
March 2019
1 Read

A perspective on the pediatric death from oral food challenge reported from the Allergy Vigilance Network.

Allergy 2019 Mar 20. Epub 2019 Mar 20.

Stanford University, Pediatrics, Stanford, California, United States.

The current edition of Allergy contains a report of 18 food allergy deaths from the French Anaphylaxis Vigilance Network (AVN) from 2002-2018 . The AVN maintains a database of food allergy related severe anaphylaxis formed of voluntary, structured reports of anonymous patients submitted by allergists. Therefore, no population estimates can be made, but important cases can be revealed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13791
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http://dx.doi.org/10.1111/all.13791DOI Listing
March 2019
7 Reads

An update on shellfish allergy.

Curr Opin Allergy Clin Immunol 2019 Mar 18. Epub 2019 Mar 18.

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Purpose Of Review: Shellfish is an important cause of food allergy worldwide, and a major cause of food-triggered anaphylaxis. Despite the wide variety of shellfish, there is considerable serological and clinical cross-reactivity of major shellfish allergens, and accurate diagnosis remains a challenge in the management of shellfish allergy.

Recent Findings: Novel minor allergens have been discovered and characterized, and advances in component resolved diagnostics have provided insights into the prevalence of sensitization and their clinical importance in shellfish allergy. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000532DOI Listing
March 2019
13 Reads

Food-dependent exercise-induced anaphylaxis.

Curr Opin Allergy Clin Immunol 2019 Mar 18. Epub 2019 Mar 18.

Children's Allergy Service, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust.

Purpose Of Review: The following article provides an overview of food-dependent exercise-induced anaphylaxis (FD-EIAn). The review focuses on the epidemiology, pathophysiology, and clinical findings of FD-EIAn and details current practice in terms of the investigation, management, and treatment options available.

Recent Findings: The management of FD-EIAn has not changed significantly over the last few years and still requires careful investigation by an experienced clinician to ensure that the correct diagnosis is made and appropriate treatment is given. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000531DOI Listing
March 2019
6 Reads

Rate of Recurrence of Adverse Events Following Immunization: Results of 19 Years of Surveillance In Quebec, Canada.

Pediatr Infect Dis J 2019 Apr;38(4):377-383

From the Department of Social and Preventive Medicine, Laval University, Quebec, Canada.

Background: While adverse events following immunization (AEFI) are frequent, there are limited data on the safety of reimmunizing patients who had a prior AEFI. Our objective was to estimate the rate and severity of AEFI recurrences.

Methods: We analyzed data from the AEFI passive surveillance system in Quebec, Canada, that collects information on reimmunization of patients who had a prior AEFI. Read More

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http://dx.doi.org/10.1097/INF.0000000000002162DOI Listing
April 2019
3 Reads

A systematic review of epinephrine stability and sterility with storage in a syringe.

Allergy Asthma Clin Immunol 2019 21;15. Epub 2019 Feb 21.

1Seattle Children's Hospital, 4800 Sandpoint Way NE, Seattle, WA 98105 USA.

Background: Epinephrine is a lifesaving medication in the treatment of anaphylaxis. Epinephrine auto-injectors are the preferred method of epinephrine administration, but are not universally available or affordable. Little is known about the effects on epinephrine when it is drawn up in advance and stored as prefilled syringes. Read More

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http://dx.doi.org/10.1186/s13223-019-0324-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383228PMC
February 2019
1 Read

Anaphylaxis after Elosulfase A infusion: Omalizumab as coadyuvant for enzyme replacement therapy desensitization.

Pediatr Allergy Immunol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, Complejo Hospitalario de Navarra. C/ Irunlarrea 4. Planta Baja. Pamplona., 31008, Spain.

Type IV A Mucopolysaccharidosis (MPS IV A) is a lysosomal storage disease caused by an autosomal recessive mutation in the gene encoding the enzyme galactosamine-6-sulfatase, which catalyses the degradation of glycosaminoglycans (GAGs). It leads to the accumulation of GAGs keratan sulfate. Symptoms include skeletal dysplasia, atlantoaxial instability, pectus carinatum, short stature, laxity of joints, cervical spinal cord compression, cardiac and pulmonary complications, corneal opacity, impaired hearing but normal cognitive development. Read More

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http://dx.doi.org/10.1111/pai.13049DOI Listing
February 2019
2 Reads

Utilization of high-fidelity simulation for medical student and resident education of allergic-immunologic emergencies.

Ann Allergy Asthma Immunol 2019 Feb 23. Epub 2019 Feb 23.

Hasbro Children's Hospital, Department of Pediatrics, Allergy & Immunology Section, Providence, Rhode Island.

Background: The advantages of clinical simulation used in medical education include the acquisition of clinical skills in a controlled setting, promoting a multidisciplinary approach to patient care, and a high degree of learner satisfaction.

Objective: We aimed to identify knowledge gaps among Internal Medicine residents and students in the diagnosis and treatment of anaphylaxis and angiotensin-converting enzyme (ACE)-inhibitor-induced angioedema through their participation in a simulation course.

Methods: We conducted a cohort study involving clinical simulations with a high-fidelity, patient-simulator. Read More

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http://dx.doi.org/10.1016/j.anai.2019.02.013DOI Listing
February 2019

Pediatric Simulation Cases for Primary Care Providers: Asthma, Anaphylaxis, Seizure in the Office.

MedEdPORTAL 2018 Oct 5;14:10762. Epub 2018 Oct 5.

Associate Professor, Department of Pediatrics, Division of Emergency Medicine, University of Washington School of Medicine.

Introduction: Although pediatric emergencies commonly occur in the outpatient setting, studies show that primary care providers often rely on hospitals or the emergency medical system to evaluate the distressed patient. This simulation-based curriculum addresses pediatric emergencies encountered by primary care providers. The cases were facilitated by faculty at an annual conference on urgent pediatric problems. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342362PMC
October 2018
1 Read

Hypoallergenic Proteins for the Treatment of Food Allergy.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):15. Epub 2019 Feb 22.

School of Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, 3330 Thurston Building, CB# 7280, Chapel Hill, NC, 27599-7280, USA.

Purpose Of Review: Food allergy is a growing health problem worldwide that impacts millions of individuals. Current treatment options are limited and strict dietary avoidance remains the standard of care. Immunotherapy using whole, native allergens is under active clinical investigation but harbors the risk of severe side effects including anaphylaxis. Read More

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http://dx.doi.org/10.1007/s11882-019-0846-6DOI Listing
February 2019
1 Read

Anaphylaxis to hidden pea protein: A Canadian pediatric case series.

J Allergy Clin Immunol Pract 2019 Feb 19. Epub 2019 Feb 19.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jaip.2019.02.010DOI Listing
February 2019
1 Read

[A CASE OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS BY SHRIMP: FRUCTOSE 1, 6- BISPHOSPHATE ALDOLASE IS SUPPOSED AS CAUSATIVE COMPONENT DESPITE NEGATIVE ALLERGEN-SPECIFIC IGE TEST (IMMUNOCAP)].

Arerugi 2019;68(1):48-53

Department of Dermatology, Osaka Habikino Medical Center.

A 16-year-old male high-school student experienced generalized itchy wheal and dyspnea during physical exercise after lunch. Each food material of his lunch was examined using a prick-prick test, allergen-specific IgE test (ImmunoCAP), and provocation test. The prick-prick test was positive for black tiger shrimp (raw and heated) and white leg shrimp (heated). Read More

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http://dx.doi.org/10.15036/arerugi.68.48DOI Listing
January 2019
1 Read

[THE ANALYSIS OF ANAPHYLAXIS DIAGNOSED AT DERMATOLOGY OF TOKYO MEDICAL UNIVERSITY HOSPITAL].

Arerugi 2019;68(1):43-47

Department of Dermatology, Tokyo Medical University.

Objective: There are few epidemiological reports of anaphylaxis since childhood. We herein examined cases of anaphylaxis diagnosed in our department.

Methods: One hundred-thirty-two patients who were examined at the Dermatology Department of Tokyo Medical University Hospital between January 2011 and March 2017 and were prescribed epinephrine autoinjector (EpiPen) for treatment were enrolled. Read More

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https://www.jstage.jst.go.jp/article/arerugi/68/1/68_43/_art
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http://dx.doi.org/10.15036/arerugi.68.43DOI Listing
January 2019
2 Reads

Adverse Events in Oral Immunotherapy for the Desensitization of Cow's Milk Allergy in Children: A Randomized Controlled Trial.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Allergy and Immunology, Department of Pediatrics, McGill University, Montreal, QC, Canada.

Background: This study focuses on the side effects of cow's milk oral immunotherapy (CM-OIT) using consensus definitions of food-induced anaphylaxis.

Objective: To evaluate the risk of allergic reactions (ARs) and to identify risk factors associated with higher risk of anaphylactic ARs (AARs) during CM-OIT in children.

Methods: Clinical charts of children receiving CM-OIT were carefully reviewed. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.007DOI Listing
February 2019
2 Reads

Anaphylaxis to Carboxymethylcellulose: Add Food Additives to the List of Elicitors.

Pediatrics 2019 Mar 14;143(3). Epub 2019 Feb 14.

Department of Pediatrics, Nagasaki University Hospital, Nagasaki, Japan.

A 14-year-old girl developed 4 episodes of anaphylaxis of unknown etiology, which required intramuscular adrenaline administration each time. She had eaten pizza and a cheeseburger immediately before the first 2 episodes, respectively, but had not eaten anything for several hours before the last 2 episodes. It turned out that she had eaten the same ice lolly 4 hours before the first 3 episodes and a Café au lait Swirkle (a half-frozen beverage) 4 hours before the last episode. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1180DOI Listing
March 2019
17 Reads

Metreleptin treatment for congenital generalized lipodystrophy type 4 (CGL4): a case report.

Clin Pediatr Endocrinol 2019 31;28(1):1-7. Epub 2019 Jan 31.

Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.

Congenital generalized lipodystrophy type 4 (CGL4) is a rare disease caused by mutations in the gene polymerase I and transcript release factor (), the main symptoms of which are systemic reductions in adipose tissue and muscular dystrophy. The strategy of treating CGL4 is to improve the insulin resistance and hypertriglyceridemia that result from systemic reductions in adipose tissue. Metreleptin, a synthetic analog of human leptin, is effective against generalized lipodystrophies; however, there are no reports of the use of metreleptin in the treatment of CGL4. Read More

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http://dx.doi.org/10.1297/cpe.28.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356095PMC
January 2019
3 Reads

Predicting outgrowth of IgE-mediated cow's milk allergy: Diagnostic tests in children under two years of age.

Allergol Immunopathol (Madr) 2019 Feb 8. Epub 2019 Feb 8.

Division of Pediatric Allergy and Immunology, Kocaeli University Faculty of Medicine, Turkey. Electronic address:

Background: Limited studies conducted on children <2 years old and/or involving a skin prick test (SPT) for fresh milk (FM) have examined the predictive value of allergometric tests for outgrowth of cow's milk allergy (CMA). We investigated the optimal decision points for outgrowth (ODP) with SPT for commercial cow's milk extract (CE) and FM and specific immunoglobulin E (sIgE) levels for milk proteins to predict outgrowing allergy in children <2 years old.

Methods: SPTs for CE and FM, tests for sIgEs (cow's milk, casein, α-lactoalbumin, β-lactoglobulin) and oral food challenges (OFC) were performed in children referred for evaluation of suspected CMA, and 15 months after diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.007DOI Listing
February 2019
2 Reads

Efficacy and safety of oral immunotherapy for peanut allergy: a pilot study in Singaporean children.

Asia Pac Allergy 2019 Jan 29;9(1):e1. Epub 2018 Oct 29.

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077.

Background: Peanut allergy is an increasing problem in Singapore and strict avoidance is difficult as peanut is ubiquitous in Asian cuisine.

Objective: We aimed to assess the efficacy and safety of peanut oral immunotherapy (OIT) in children with obvious peanut allergy in Singapore.

Methods: This was an open-label study of peanut OIT in children living in Singapore, with 2 weekly dose escalation until final maintenance dose of 3,000 mg of peanut protein and a maintenance phase of 12 months. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365660PMC
January 2019
2 Reads

Home-based cow's milk reintroduction using a milk ladder in children less than 3 years old with IgE-mediated cow's milk allergy.

Clin Exp Allergy 2019 Feb 8. Epub 2019 Feb 8.

Children's Allergy Service, University Hospitals of Leicester NHS Trust, Leicester, UK.

Background: The development of tolerance to cow's milk in allergic children is best determined by supervised baked milk exposure. Widely recommended hospital-based challenges can potentially delay contact because of resource limitations.

Objective: We sought to determine the efficacy and safety of our low-dose home-based reintroduction programme. Read More

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http://dx.doi.org/10.1111/cea.13366DOI Listing
February 2019
3 Reads

Guiding Principles for the Recognition, Diagnosis, and Management of Infants with Anaphylaxis: An Expert Panel Consensus.

J Allergy Clin Immunol Pract 2019 Apr 5;7(4):1148-1156.e5. Epub 2019 Feb 5.

Division of Allergy and Immunology, University of Tennessee Health Science Center, Memphis, Tenn.

Infant anaphylaxis is an emerging risk, with food allergy the most common cause. Although the presentation of anaphylaxis involves the same systems as in older children and adults, there are real-world challenges to identifying symptoms of an allergic emergency in nonverbal children, as well as implementing optimal treatment. Recognition of anaphylaxis in infants can be challenging because allergic symptoms and certain normal infant behaviors may overlap. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.10.052DOI Listing
April 2019
5 Reads

Urban/rural residence effect on emergency department visits arising from food-induced anaphylaxis.

Allergol Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Pediatrics and Adolescent Medicine, Juntendo University, School of Medicine, Tokyo, Japan.

Background: Anaphylaxis is a severe and potentially fatal allergic response. Early-life exposure to rural environments may help protect against allergic reaction. This study assesses urban/rural differences by age and race/ethnicity in emergency department (ED) pediatric visit rates for food-induced anaphylaxis. Read More

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http://dx.doi.org/10.1016/j.alit.2018.12.007DOI Listing
February 2019
14 Reads

Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Geneva University Hospitals, Department of child and adolescent, Pediatric Allergy Unit, Geneva, Switzerland.

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Read More

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http://dx.doi.org/10.1111/pai.13034DOI Listing
February 2019
2 Reads

Management of Peanut Allergy.

J Allergy Clin Immunol Pract 2019 Feb;7(2):345-355.e2

Section of Allergy and Immunology, Children's Hospital Colorado, Food Challenge and Research Unit, University of Colorado School of Medicine, Aurora, Colo.

Peanut allergy is a growing public health concern in westernized countries. Peanut allergy is characterized as an often severe and lifelong allergy, which can have detrimental effects on quality of life and trigger anxiety. Although multiple therapeutic options are emerging, the focus of current management strategies is strict peanut avoidance and carriage of self-injectable epinephrine. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.10.043DOI Listing
February 2019
3 Reads

The global incidence and prevalence of anaphylaxis in children in the general population: A systematic review.

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Background: Despite an increasing number of publications from individual countries and regions, there is still no systematic review of the global epidemiology of anaphylaxis in the general paediatric population.

Methods: We conducted a systematic review, using a protocol registered and published with the international prospective register of systematic reviews (PROSPERO). Results were reported following PRISMA guidelines. Read More

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http://dx.doi.org/10.1111/all.13732DOI Listing
January 2019
4 Reads

Common causes of emergency department visits for anaphylaxis in Korean community hospitals: A cross-sectional study.

Medicine (Baltimore) 2019 Jan;98(4):e14114

Division of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, Korea.

Anaphylaxis can cause death and requires immediate management. For prevention and education programs for anaphylaxis, it is important to be aware of the common triggering factors. We investigated the triggers of anaphylaxis in the emergency departments (EDs) of community hospitals in Korea. Read More

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http://dx.doi.org/10.1097/MD.0000000000014114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358383PMC
January 2019
12 Reads

Anaphylaxis to patent blue dye in a 17-year-old boy.

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

Division of Allergy Immunology and Dermatology, Department of Paediatrics, McGill University Health Centre, Montreal, Quebec, Canada.

Patent blue V dye (PBV) is frequently used as a perioperative drug for lymphangiography, as well as a food additive. Hypersensitivity to PBV is poorly documented in adults and had not been previously described in children. The diagnosis of PBV allergy depends on corroboration of history consistent with an IgE-mediated reaction and confirmatory skin tests. Read More

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http://dx.doi.org/10.1136/bcr-2018-226191DOI Listing
January 2019
3 Reads

Omalizumab in children with severe allergic disease: a case series.

Ital J Pediatr 2019 Jan 14;45(1):13. Epub 2019 Jan 14.

Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy.

Background: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. Read More

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http://dx.doi.org/10.1186/s13052-019-0602-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332555PMC
January 2019
4 Reads
1.236 Impact Factor

Who needs to carry an epinephrine autoinjector?

Cleve Clin J Med 2019 01;86(1):66-72

Department of Medicine and Pediatrics, University of Tennessee College of Medicine, Memphis, TN, USA.

Patients who have had anaphylaxis or who are at risk of it (eg, due to food allergy or Hymenoptera hypersensitivity) should carry an epinephrine autoinjector at all times. However, the risks and benefits must be considered on an individual basis, especially in patients with atherosclerotic heart disease, elderly patients on polypharmacy, patients receiving allergen immunotherapy, those with large local reactions to insect stings, and individuals with oral allergy syndrome. Read More

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http://dx.doi.org/10.3949/ccjm.86a.17123DOI Listing
January 2019
4 Reads

Authors' reply - anaphylactic shock with methylprednisolone, Kounis syndrome and Hypersitivity to corticosteroids: a clinical paradox.

Ital J Pediatr 2019 01 7;45(1). Epub 2019 Jan 7.

Respiratory Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, 00165, Rome, Italy.

In our letter, we comment the paper of Kounis et al., that highlights a poor-known clinical entity determined by systemic use of corticosteroids, the so-called "Kounis syndrome type I". We appreciated and shared the intent of Authors to treat the important issue of high risk of adverse drug reaction in patients with atopic diathesis and we confirm the need to administer corticosteroids with caution in patients suffering from allergic disease. Read More

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http://dx.doi.org/10.1186/s13052-018-0600-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323731PMC
January 2019
2 Reads
1.236 Impact Factor

The Diagnosis of Ceftriaxone Hypersensitivity in a Paediatric Population.

Int Arch Allergy Immunol 2019 3;178(3):272-276. Epub 2019 Jan 3.

Department of Paediatrics, Allergy Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Introduction: Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity in a population of children with suspected HRs to this drug and their tolerance toward amoxi-cillin/clavulanic acid (AMX/CLV). Read More

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http://dx.doi.org/10.1159/000495302DOI Listing
January 2019
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Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study.

Clin Exp Allergy 2019 Apr 12;49(4):442-460. Epub 2019 Mar 12.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.

Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Read More

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http://dx.doi.org/10.1111/cea.13333DOI Listing
April 2019
14 Reads

Anaphylaxis admissions in pediatric intensive care units: Follow-up and risk of recurrence.

Pediatr Allergy Immunol 2018 Dec 27. Epub 2018 Dec 27.

Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, CHU Lille, Lille, France.

Background: Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow-up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis.

Methods: We conducted a telephone survey of 166 children (≤18 years) hospitalized from 2003 to 2013. Read More

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http://dx.doi.org/10.1111/pai.13015DOI Listing
December 2018
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Insights from 275 Cases of Childhood Anaphylaxis in the United States.

J Allergy Clin Immunol Pract 2018 Dec 21. Epub 2018 Dec 21.

Department of Pediatrics, Section of Pediatric Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Department of Pediatrics, Section of Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.12.013DOI Listing
December 2018
2 Reads