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Ther Drug Monit 2022 May 13. Epub 2022 May 13.

Laboratoire de Pharmacologie, Toxicologie et Gaz du Sang, CHU de Saint Etienne, France.

Introduction: The accepted treatment for patients with acetaminophen/paracetamol overdose includes risk assessment based on the Rumack-Matthew (R-M) nomogram. Inaccurate use of the nomogram may result in improper treatment. Clinicians were surveyed to determine their understanding and proper use of this risk assessment tool in practice. Read More

Ital J Pediatr 2022 May 16;48(1):76. Epub 2022 May 16.

Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

BNT162b2 vaccine, developed by BioNTech and Pfizer ha recently approved for use in children aged 5 to 11 years. Recent data show evidence of safety on the administration and serious adverse events have been rarely reported. However, allergic systemic reactions could occur. Read More

Asia Pac Allergy 2022 Apr 15;12(2):e14. Epub 2022 Apr 15.

Department of Pediatrics, National Hospital Organization Fukuoka National Hospital, Fukuoka, Japan.

Background: Despite being frequently recommended, adrenaline auto-injectors (AAIs) are insufficiently prescribed and used for the prehospital management of anaphylaxis.

Objective: This study aimed to investigate recent changes in the clinical features and prehospital management of food-related anaphylaxis in children.

Methods: We retrospectively compared the clinical features of children who were hospitalized for food-related anaphylaxis in 2013 and 2018. Read More

Arerugi 2022 ;71(3):231-241

Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital.

Background: The epidemiology of drug-induced anaphylaxis (AN) using the Japanese nationwide database has not been reported, even though drugs are a common trigger of AN.

Objective: This study aimed to describe the epidemiological profile of drug-induced AN, including fatal cases, using the Japanese Adverse Drug Event Report database (JADER).

Methods: We extracted data regarding drug-induced adverse events between April 2004 and February 2018 published in JADER by the Pharmaceuticals and Medical Devices Agency. Read More

J Allergy Clin Immunol Pract 2022 May 12. Epub 2022 May 12.

Department of Pediatrics, NYU Langone Health; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.

The appropriate at home management of anaphylaxis begins with patient education on recognition and treatment, especially when and how to use epinephrine. Delayed administration of epinephrine as well as having severe symptoms and needing multiple doses of epinephrine to treat symptoms are risk factors for biphasic anaphylaxis. The successful implementation of at home management of anaphylaxis requires appropriate patient selection and an algorithmic approach that recommends activation of emergency medical services (EMS) when the patient does not adequately respond to at home administration of epinephrine or there are extenuating patient related circumstances. Read More

World Allergy Organ J 2022 Apr 23;15(4):100646. Epub 2022 Apr 23.

Pediatric Primary Care, National Pediatric Health Care System, Milan, Italy.

Background: The prevalence of cow's milk allergy (CMA) is approximately 2-4.5% in infants and less than 0.5% in adults. Read More

Elife 2022 May 10;11. Epub 2022 May 10.

Department of Paediatrics, University of Melbourne, Parkville, Australia.

Background: The risk of adult onset cardiovascular and metabolic (cardiometabolic) disease accrues from early life. Infection is ubiquitous in infancy and induces inflammation, a key cardiometabolic risk factor, but the relationship between infection, inflammation, and metabolic profiles in early childhood remains unexplored. We investigated relationships between infection and plasma metabolomic and lipidomic profiles at age 6 and 12 months, and mediation of these associations by inflammation. Read More

Allergy 2022 May 9. Epub 2022 May 9.

Food Allergy Research and Resource Program, University of Nebraska, Lincoln, Nebraska, USA.

Vaccine 2022 May 27;40(24):3305-3312. Epub 2022 Apr 27.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; ICES, Toronto, ON, Canada; Public Health Ontario, ON, Canada; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada. Electronic address:

Background: Background incidence rates are critical in pharmacovigilance to facilitate identification of vaccine safety signals. We estimated background incidence rates of 11 adverse events of special interest related to COVID-19 vaccines in Ontario, Canada.

Methods: We conducted a population-based retrospective observational study using linked health administrative databases for hospitalizations and emergency department visits among Ontario residents. Read More

J Allergy Clin Immunol Pract 2022 May 5. Epub 2022 May 5.

Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Background: Hereditary angioedema (HAE) is known for its mortality when not treated properly. Many advances have occurred over the last decades that impacted the patients' lives. However, not all patient populations have access to the same diagnosis and treatment resources. Read More

Clin Exp Allergy 2022 May 7. Epub 2022 May 7.

Section of Pediatrics, Department of Health Sciences, University of Florence and Meyer Children's Hospital, Florence, Italy.

Allergy 2022 May 7. Epub 2022 May 7.

Baylor College of Medicine, Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Retrovirology, Houston, Texas, USA.

S Afr Med J 2021 Dec 24;112(2b):13486. Epub 2021 Dec 24.

South African Medical Research Council, South Africa; Department of Paediatrics and Child Health, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa.

Sisonke is a multicentre, open-label, single-arm phase 3B vaccine implementation study of healthcare workers (HCWs) in South Africa, with prospective surveillance for 2 years. The primary endpoint is the rate of severe COVID‑19, including hospitalisations and deaths. The  Sisonke study enrolled and vaccinated participants nationally at potential vaccination roll-out sites between 17 February and 26 May 2021. Read More

Curr Treat Options Allergy 2022 Apr 28:1-18. Epub 2022 Apr 28.

Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.

Purpose Of Review: Food allergy management and treatment require dietary modification, are associated with significant burdens, and affect food choices and behaviours. Emerging therapies, such as oral immunotherapy (OIT), provide a glimmer of hope for those living with the condition. Some burdens have received substantial focus, whereas many knowledge gaps on the significance of other impacts, including economic burden, remain. Read More

Ann Allergy Asthma Immunol 2022 Apr 29. Epub 2022 Apr 29.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Limited data exist on the economic burden of food allergy (FA).

Objective: To assess FA-related direct (healthcare and out-of-pocket) and indirect (lost productivity) costs and their determinants in Canadian children and adults self-reporting FA.

Methods: FA-individuals self-reporting a convincing history and/or physician diagnosis were recruited through FA registries, an anaphylaxis registry, and advocacy associations, and electronically surveyed regarding FA-related healthcare use, out-of-pocket expenditures, and time lost from paid/unpaid labour. Read More

Zhonghua Er Ke Za Zhi 2022 May;60(5):447-451

Department of Allergy, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.

To analyze the clinical features of IgE-mediated cow's milk protein allergy (CMPA) in children aged 0-5 years. This cross-sectional study collected the data on children diagnosed with CMPA in the Department of Allergy at the Children's Hospital of the Capital Institute of Pediatrics from October 2019 to November 2020 and improved peripheral blood routine,total IgE defection, milk specific IgE (sIgE) defection,SPT and milk component defection,diagnosis of severe anaphylaxis based on clinical manifestations. Rank-sum test and chi-square test are used for statistical analysis of clinical characteristics between groups. Read More

Clin Mol Allergy 2022 Apr 29;20(1). Epub 2022 Apr 29.

Center for Pediatrics and Adolescent Medicine, University Medical Centre and Faculty of Medicine Freiburg, Freiburg, Germany.

Background: Anaphylaxis occurs in up to 3.5% of hymenoptera stings and can be a life-threatening emergency. Venom immunotherapy (VIT) provides excellent protection from further episodes of anaphylaxis and is well tolerated. Read More

PLoS One 2022 29;17(4):e0266712. Epub 2022 Apr 29.

Department of Pediatrics, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

Background: Anaphylaxis is an allergic disease with fatal respiratory or cardiovascular symptoms that require immediate emergency treatment. We aimed to understand the characteristics and frequency of emergency department (ED) visits of patients with anaphylaxis in Korea.

Methods: Between 2007 and 2013, using data from 147 ED from the National Emergency Department Information System in Korea, we retrospectively evaluated patients with a primary diagnosis of anaphylaxis. Read More

Clin Exp Allergy 2022 May;52(5):595-597

Royal National ENT Hospital, University College London Hospitals, London, UK.

Int Arch Allergy Immunol 2022 Apr 25:1-8. Epub 2022 Apr 25.

Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.

The aim of this study was to assess the compliance between current guidelines on the diagnosis and management of children with cow's milk allergy (CMA) and clinical practice by a survey of Polish physicians. An online cross-sectional survey involving a convenience series of participants was performed from January 15 to March 20, 2020. Data provided by 605 physicians (74. Read More

Pediatr Rep 2022 Apr 8;14(2):170-174. Epub 2022 Apr 8.

Pediatrics and Neonatology Unit, Department of Maternal and Child Health, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy.

Fish roe are not yet described as triggers of allergic reactions in Italy, especially during the pediatric age; they are more frequently involved in anaphylaxis in Eastern countries, such as Japan. For this report, we reported a case of anaphylaxis in a 2-year-old boy admitted to our Hospital Pediatric Emergency Room with a suspected allergic reaction. 15 min after the meal, he presented generalized urticaria, angioedema, wheezing, sneezing, and two vomiting episodes. Read More

J Med Cases 2022 Apr 25;13(4):159-162. Epub 2022 Mar 25.

Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

During the perioperative period, the most commonly identified agents that are responsible for acute allergic reactions include antibiotics, neuromuscular blocking agents, opioids, chlorhexidine, and iodinated dyes for radiologic imaging. However, whenever an allergic reaction is suspected, all of the agents to which the patient has been exposed must be considered. Although bleomycin is utilized as the primary agent for sclerotherapy in the treatment of vascular malformations, other substances such as Surgiflo may be added to the bleomycin solution to increase its efficacy and promote thrombosis of the smaller vessels. Read More

Allergol Int 2022 Apr 18. Epub 2022 Apr 18.

Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan. Electronic address:

Background: Early food introduction induces tolerance, but epicutaneous exposure, especially via eczema lesions, promotes IgE sensitization. Aiming for safe and effective primary prevention of egg allergy, we examined several protease-digested egg-white (EW) products for three properties: 1) induction of oral tolerance that prevents IgE sensitization, 2) weak IgE binding that can prevent allergic reactions even in IgE-sensitized mice, and 3) minimal epicutaneous IgE sensitization even when in contact with inflamed skin.

Methods: Heated EW was digested with several proteases under optimal conditions. Read More

Pediatr Int 2022 01;64(1):e15163

Department of Allergy, Miyagi Children's Hospital, Sendai, Japan.

Allergy Asthma Clin Immunol 2022 Apr 18;18(1):34. Epub 2022 Apr 18.

Department of Legal Medicine, Nara Medical University School of Medicine, Kashihara, Japan.

Background: The determinants of tolerance to food allergens are not fully understood. We aimed to elucidate the longitudinal association between oropharyngeal symptoms without systemic reactions (OSw/oS) and tolerance to food allergens.

Methods: We included all patients diagnosed with single food allergy to egg (n = 121), milk (n = 55), and wheat (n = 41) using the oral food challenge test (OFC) from 2014 to 2017. Read More

Front Pharmacol 2022 28;13:845689. Epub 2022 Mar 28.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

For anaphylaxis, a life-threatening allergic reaction, the incidence rate was presented to have increased from the beginning of the 21st century. Underdiagnosis and undertreatment of anaphylaxis are public health concerns. This guideline aimed to provide high-quality and evidence-based recommendations for the emergency management of anaphylaxis. Read More

J Allergy Clin Immunol 2022 Apr 7. Epub 2022 Apr 7.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

Anaphylaxis is a life-threatening condition and when associated with vaccination, leads to vaccine hesitancy. The concerns around vaccine related anaphylaxis have become even more important during the COVID-19 pandemic where the COVID-19 vaccines remain one of our most important tools. While rates of anaphylaxis to COVID-19 vaccines are not significantly different from other vaccines, CDC guidance recommends avoidance of the same COVID-19 vaccine in individuals who had an allergic reaction or are allergic to a COVID-19 vaccine component. Read More

Allergy 2022 Apr 9. Epub 2022 Apr 9.

Department of Medicine, Division of Clinical Immunology and Allergy, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: There is limited ability to predict the severity of allergic reactions in children. Data derived predominantly from adults have implicated the platelet-activating factor pathway as a potential contributor to severe anaphylaxis. In this study, we sought to prospectively assess involvement of key components of the platelet-activating factor pathway in pediatric patients with anaphylaxis. Read More

Front Allergy 2021 1;2:618713. Epub 2021 Apr 1.

Department of Pediatrics, Kindai University Faculty of Medicine, Osakasayama, Japan.

Oral food challenge (OFC) is the most reliable method for diagnosing food allergies. However, the scarcity of long-term data on eating habits of people after a negative OFC poses a challenge for provisional medical care. This study was performed to investigate the percentage of people who could reintroduce eggs into their diet several years after an OFC. Read More

Front Allergy 2021 6;2:677019. Epub 2021 Sep 6.

Departments of Pediatrics and Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United States.

Neonatal mice with heterozygous mutations in genes encoding the skin barrier proteins filaggrin and mattrin (flaky tail mice [FT]) exhibit oral peanut-induced anaphylaxis after skin sensitization. As we have previously reported, sensitization in this model is achieved via skin co- exposure to the environmental allergen (Alt), peanut extract (PNE), and detergent. However, the function of Alt in initiation of peanut allergy in this model is little understood. Read More