7,963 results match your criteria Pediatric nephrology[Journal]


Burden, access, and disparities in kidney disease.

Pediatr Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1007/s00467-019-4197-2DOI Listing
February 2019

Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.

Pediatr Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Division of Nephrology, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.

Intradialytic hypotension (IDH) is a common adverse event resulting in premature interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH occurs in response to the reduction in blood volume during ultrafiltration and subsequent poor compensatory mechanisms due to abnormal cardiac function or autonomic or baroreceptor failure. Pediatric patients are inherently at risk for IDH due to the added difficulty of determining and attaining an accurate dry weight. Read More

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http://dx.doi.org/10.1007/s00467-018-4190-1DOI Listing
February 2019
2 Reads
2.856 Impact Factor

Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children.

Pediatr Nephrol 2019 Feb 4. Epub 2019 Feb 4.

Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from several European medical centres.

Methods: Three thousand four hundred eight measurements of GFR (mGFR) using plasma clearance of exogenous substances were performed in 2218 children aged 2-17 years. Read More

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http://dx.doi.org/10.1007/s00467-018-4185-yDOI Listing
February 2019
1 Read

Patent ductus arteriosus is associated with acute kidney injury in the preterm infant.

Pediatr Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatrics, Division of Pediatric Nephrology, New York Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, 10032, USA.

Background: This study aimed to test the hypothesis that a patent ductus arteriosus (PDA) is independently associated with acute kidney injury (AKI) in neonates ≤ 28 weeks gestation.

Methods: Preterm infants with echocardiographic diagnosis of moderate-large PDA at age ≤ 30 days were studied retrospectively. AKI, the primary outcome, was defined and staged according to serum creatinine using Kidney Disease Improving Global Outcomes (KDIGO) neonatal criteria. Read More

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http://dx.doi.org/10.1007/s00467-019-4194-5DOI Listing
January 2019

Malaria and acute kidney injury.

Pediatr Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatric Nephrology at The Children's Hospital at Montefiore, 3326 Bainbridge Ave, Bronx, NY, 10029, USA.

Malaria is a parasitic infection transmitted by mosquitos, resulting in significant morbidity and mortality. It affects 212 million worldwide, causing death in up to 303,000 children annually. In the USA, up to 1700 people are affected yearly. Read More

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http://link.springer.com/10.1007/s00467-018-4191-0
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http://dx.doi.org/10.1007/s00467-018-4191-0DOI Listing
January 2019
3 Reads

First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction.

Pediatr Nephrol 2019 Jan 29. Epub 2019 Jan 29.

Pediatric Nephrology Unit, Department of Pediatrics, Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 647, São Paulo, CEP: 05403-000, SP, Brazil.

Background: Diagnosis of renal function impairment and deterioration in congenital urinary tract obstruction (UTO) continues to be extremely challenging. Use of renal biomarkers in this setting may favor early renal injury detection, allowing for a reliable choice of optimal therapeutic options and prevention or minimization of definitive renal damage.

Methods: This longitudinal, prospective study analyzed the first-year profile of two serum renal biomarkers: creatinine (sCr) and cystatin C (sCyC); and six urinary renal biomarkers: neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-β1), retinol-binding protein (RBP), cystatin C (uCyC), and microalbuminuria (μALB) in a cohort of 37 infants with UTO divided into three subgroups: 14/37 with unilateral hydro(uretero)nephrosis, 13/37 with bilateral hydro(uretero)nephrosis, and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. Read More

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http://dx.doi.org/10.1007/s00467-019-4195-4DOI Listing
January 2019
1 Read

Optimal duration of treatment with eculizumab in atypical hemolytic uremic syndrome (aHUS)-a question to be addressed in a scientific way.

Authors:
Gema Ariceta

Pediatr Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Pediatric Nephrology, Hospital Universitari Vall d' Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00467-019-4192-7DOI Listing
January 2019
1 Read

Correction to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients.

Pediatr Nephrol 2019 Jan 25. Epub 2019 Jan 25.

Department of Pediatrics, Division of Pediatric Nephrology, SSM Cardinal Glennon Children's Hospital, Saint Louis University, St. Louis, MO, USA.

The original version of this article unfortunately contained a mistake. The name of Vimal Chadha was presented incorrectly. The corrected author list is given above. Read More

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http://dx.doi.org/10.1007/s00467-019-4199-0DOI Listing
January 2019
2 Reads

The role of bladder function in the pathogenesis and treatment of urinary tract infections in toilet-trained children.

Pediatr Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Division of Urology, Hospital for Sick Children and Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Urinary tract infections (UTIs) are a common reason for referral to pediatric specialists and the risk profile of these children is influenced by age, sex, and underlying urinary tract abnormalities. UTIs in toilet-trained children represent a different entity than confirmed, febrile UTIs that occur in infants, impacted by suboptimal bladder habits, bladder dysfunction, constipation, or a combination of these factors. A comprehensive literature search was conducted using PubMed and MEDLINE and search terms included recurrent UTI, VUR, bladder and bowel dysfunction (BBD), constipation, lower urinary tract symptoms, and voiding dysfunction. Read More

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http://dx.doi.org/10.1007/s00467-019-4193-6DOI Listing
January 2019
3 Reads

HNF1B nephropathy has a slow-progressive phenotype in childhood-with the exception of very early onset cases: results of the German Multicenter HNF1B Childhood Registry.

Pediatr Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Pediatric Nephrology, University Children's Hospital Marburg, Baldingerstrasse 1, 35033, Marburg, Germany.

Background: HNF1B gene mutations are an important cause of bilateral (cystic) dysplasia in children, complicated by chronic renal insufficiency. The clinical variability, the absence of genotype-phenotype correlations, and limited long-term data render counseling of affected families difficult.

Methods: Longitudinal data of 62 children probands with genetically proven HNF1B nephropathy was obtained in a multicenter approach. Read More

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http://dx.doi.org/10.1007/s00467-018-4188-8DOI Listing
January 2019
4 Reads

The unusual suspects: a curious case of acute kidney injury-Answers.

Pediatr Nephrol 2019 Jan 16. Epub 2019 Jan 16.

Seattle Children's Hospital, Division of Nephrology, University of Washington, 4800 Sand Point Way, Seattle, WA, 98105, USA.

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http://dx.doi.org/10.1007/s00467-018-4168-zDOI Listing
January 2019
1 Read

The unusual suspects: a curious case of acute kidney injury-Questions.

Pediatr Nephrol 2019 Jan 16. Epub 2019 Jan 16.

Seattle Children's Hospital, Division of Nephrology, University of Washington, 4800 Sand Point Way, Seattle, WA, 98105, USA.

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http://dx.doi.org/10.1007/s00467-018-4156-3DOI Listing
January 2019
1 Read

Correction to: Eculizumab in atypical hemolytic uremic syndrome: strategies toward restrictive use.

Pediatr Nephrol 2019 Jan 15. Epub 2019 Jan 15.

Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Department of Pediatric Nephrology, Radboud University Medical Center, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.

The original version of this article unfortunately contained two mistakes. The presentation of Table 1 and Fig. 1 was incorrect. Read More

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http://link.springer.com/10.1007/s00467-018-4186-x
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http://dx.doi.org/10.1007/s00467-018-4186-xDOI Listing
January 2019
4 Reads

Short stature in advanced pediatric CKD is associated with faster time to reduced kidney function after transplant.

Pediatr Nephrol 2019 Jan 9. Epub 2019 Jan 9.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Among children who receive a kidney transplant, short stature is associated with a more complicated post-transplant course and increased mortality. Short stature prior to transplant may reflect the accumulated risk of multiple factors during chronic kidney disease (CKD); however, its relationship with post-transplant kidney function has not been well characterized.

Methods: In the Chronic Kidney Disease in Children (CKiD) cohort restricted to children who received a kidney transplant, short stature (i. Read More

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http://dx.doi.org/10.1007/s00467-018-4165-2DOI Listing
January 2019
2 Reads

A breakthrough in readthrough? Could geneticin lead the way to effective treatment for cystinosis nonsense mutations?

Authors:
Julian Midgley

Pediatr Nephrol 2019 Jan 8. Epub 2019 Jan 8.

Alberta Children's Hospital, Section of Paediatric Nephrology, Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada.

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http://link.springer.com/10.1007/s00467-018-4173-2
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http://dx.doi.org/10.1007/s00467-018-4173-2DOI Listing
January 2019
5 Reads

Quality improvement in pediatric nephrology-a practical guide.

Pediatr Nephrol 2019 Jan 5. Epub 2019 Jan 5.

Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Improving quality of care delivery is an important focus for all practicing physicians. Frontline clinicians are in a great position to identify clinical problems and find innovative solutions. The current review describes the method used for quality improvement based on the Model for Improvement, a structural framework to guide improvement work. Read More

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http://link.springer.com/10.1007/s00467-018-4175-0
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http://dx.doi.org/10.1007/s00467-018-4175-0DOI Listing
January 2019
10 Reads

Haemodiafiltration use in children: data from the Italian Pediatric Dialysis Registry.

Pediatr Nephrol 2019 Jan 5. Epub 2019 Jan 5.

Dialysis Unit, Paediatric Nephrology and Dialysis Department, G Gaslini Children Hospital, Genoa, Italy.

Background: High volume haemodiafiltration (HDF) is associated with better survival than conventional haemodialysis (HD) in adults, but data concerning its use in children are lacking. The aim of this study was to assess the prevalence of paediatric HDF use and its associated factors in recent years in Italy.

Methods: We retrospectively reviewed the files of patients from the Italian Pediatric Dialysis Registry's database who were registered between January 1, 2004 and December 31, 2016 and treated with extracorporeal dialysis for at least 6 months, looking in particular at modality and its associated factors. Read More

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http://link.springer.com/10.1007/s00467-018-4184-z
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http://dx.doi.org/10.1007/s00467-018-4184-zDOI Listing
January 2019
5 Reads

Risk of cardiovascular involvement in pediatric patients with X-linked hypophosphatemia.

Pediatr Nephrol 2019 Jan 4. Epub 2019 Jan 4.

University of Oviedo, Oviedo, Spain.

Objective: To find out if cardiovascular alterations are present in pediatric patients with X-linked hypophosphatemia (XLH).

Study Design: Multicentre prospective clinical study on pediatric patients included in the RenalTube database ( www.renaltube. Read More

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http://dx.doi.org/10.1007/s00467-018-4180-3DOI Listing
January 2019
2 Reads

Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones.

Pediatr Nephrol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6A 5W9, Canada.

Background: The incidence of nephrolithiasis in children and adolescents is increasing and appears to double every 10 years. The most important role of the pediatric nephrologist is to diagnose and modify various metabolic and non-metabolic risk factors, as well as prevent long-term complications especially in the case of recurrent nephrolithiasis.

Objective: The purpose of this review is to summarize the existing literature on the etiology and management of pediatric nephrolithiasis. Read More

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http://dx.doi.org/10.1007/s00467-018-4179-9DOI Listing
January 2019
7 Reads

Clinical and histopathological prognostic factors affecting the renal outcomes in childhood ANCA-associated vasculitis.

Pediatr Nephrol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are very rare in childhood with an increased risk of morbidity and mortality. We aimed to evaluate renal prognostic factors in childhood AAV from the perspective of ANCA serotype, histopathological classification, and five-factor score (FFS).

Methods: Pediatric AAV patients from 11 referral centers in Turkey had been included to the study. Read More

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http://dx.doi.org/10.1007/s00467-018-4162-5DOI Listing
January 2019
1 Read

Kidney and organoid single-cell transcriptomics: the end of the beginning.

Pediatr Nephrol 2019 Jan 4. Epub 2019 Jan 4.

Division of Nephrology, Department of Medicine, Washington University in Saint Louis School of Medicine, 660 S. Euclid Ave., CB 8126, St. Louis, MO, 63110, USA.

Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney development and disease. In just the last year, multiple scRNA-seq datasets have been generated from kidney organoids, developing mouse and human kidney, adult kidney, and kidney cancer. The data generated enables a much deeper understanding of biological processes within and between cells. Read More

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http://dx.doi.org/10.1007/s00467-018-4177-yDOI Listing
January 2019

Factors associated with high-cost hospitalization for peritonitis in children receiving chronic peritoneal dialysis in the United States.

Pediatr Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Division of Pediatric Nephrology, Children's Mercy Kansas City, 2401 Gillham Rd., Kansas City, MO, 64108, USA.

Background: Although peritonitis causes significant morbidity and mortality in children receiving chronic peritoneal dialysis (CPD), little is known about costs associated with treatment.

Methods: We analyzed 246 peritonitis-related hospitalizations in the USA, linked by the Standardized Care to Improve Outcomes in Pediatric End Stage Renal Disease (SCOPE) and Pediatric Health Information Systems (PHIS) databases. Multivariable logistic regression was used to assess the relationship between high-cost hospitalizations (at or above the 75th percentile) and patient characteristics. Read More

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http://link.springer.com/10.1007/s00467-018-4183-0
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http://dx.doi.org/10.1007/s00467-018-4183-0DOI Listing
January 2019
5 Reads

Endurance training during maintenance hemodialysis in pediatric and adolescent patients-theory and best practice suggestions.

Pediatr Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Division of Pediatric Nephrology, Department of Pediatrics, University Children's Hospital Bonn, Adenauerallee 119, D-53113, Bonn, Germany.

Patients on maintenance hemodialysis (HD) spend significant sedentary time traveling to and receiving dialysis, which leaves little time for social or sport events. Also, chronic HD patients are not physically fit, too exhausted after HD, and are not necessarily motivated to perform sports. There is increasing evidence that endurance training during HD can both increase dialysis efficacy and improve the ability of patients to participate in social life. Read More

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http://link.springer.com/10.1007/s00467-018-4182-1
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http://dx.doi.org/10.1007/s00467-018-4182-1DOI Listing
January 2019
1 Read

Pheochromocytoma and paraganglioma-an update on diagnosis, evaluation, and management.

Pediatr Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Division of Pediatric Nephrology and Hypertension, Children's Hospital of Michigan, Wayne State University School of Medicine, 5th Floor, Carl's Building, 3901 Beaubien Blvd, Detroit, MI, 48201, USA.

Pheochromocytomas and paragangliomas (PPGLs) generally grouped together are rare catecholamine-secreting endocrine tumors. Symptoms of catecholamine excess are non-specific and therefore a high index of suspicion in children with sustained hypertension, family history of endocrine tumors, or features of syndromes associated with PPGLs leads to a timely diagnosis and treatment. Free metanephrines in the plasma or 24-h urine are the preferred tests to establish catecholamine excess. Read More

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http://dx.doi.org/10.1007/s00467-018-4181-2DOI Listing
January 2019
1 Read

Genetic studies of focal segmental glomerulosclerosis: a waste of scientific time?

Pediatr Nephrol 2018 Dec 27. Epub 2018 Dec 27.

Department of Pathology, Department of Cellular Pathology, Royal Free Hospital, University College London, London, NW3 2QG, UK.

Many genetic causes of focal segmental glomerulosclerosis (FSGS) have been described. A paradox is that the science in the molecular biology, which generally appears of high quality, is not mirrored by a similarly critical analysis of the renal pathology. FSGS has been applied to such a wide range of conditions that it can reasonably be said to have no useful meaning. Read More

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http://dx.doi.org/10.1007/s00467-018-4161-6DOI Listing
December 2018
1 Read

Hemodialysis vascular access and subsequent transplantation: a report from the ESPN/ERA-EDTA Registry.

Pediatr Nephrol 2018 Dec 26. Epub 2018 Dec 26.

Department of Pediatric Nephrology, University Children's Hospital, Heidelberg, Germany.

Background: Current guidelines advocate use of arteriovenous fistula (AVF) over central venous catheter (CVC) for children starting hemodialysis (HD). European data on current practice, determinants of access choice and switches, patient survival, and access to transplantation are limited.

Methods: We included incident patients from 18 European countries who started HD from 2000 to 2013 for whom vascular access type was reported to the ESPN/ERA-EDTA Registry. Read More

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http://dx.doi.org/10.1007/s00467-018-4129-6DOI Listing
December 2018
2.856 Impact Factor

Predictors of grade 3-5 vesicoureteral reflux in infants ≤ 2 months of age with pyelonephritis.

Pediatr Nephrol 2018 Dec 26. Epub 2018 Dec 26.

Department of Pediatrics, Assaf Harofeh Medical Center, 70300, Zerifin, Israel.

Background: This study aimed to assess predictors for grade 3-5 vesicoureteral reflux (VUR) in infants ≤ 2 months of age admitted for first urinary tract infection (UTI).

Methods: Retrospective cohort study of 195 infants ≤ 2 months admitted to a pediatric ward for first UTI between 2006 and 2017. Clinical, laboratory, and imaging data were collected from electronic medical charts. Read More

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http://dx.doi.org/10.1007/s00467-018-4167-0DOI Listing
December 2018
1 Read

CoenzymeQ10 therapy in two sisters with CoQ6 mutations with long-term follow-up.

Pediatr Nephrol 2018 Dec 26. Epub 2018 Dec 26.

School of Medicine, Department of Pediatrics, Division of Pediatric Nephrology, Akdeniz University, 07070, Antalya, Turkey.

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http://link.springer.com/10.1007/s00467-018-4150-9
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http://dx.doi.org/10.1007/s00467-018-4150-9DOI Listing
December 2018
1 Read

Persistent fever in a pediatric renal transplant patient: Answers.

Pediatr Nephrol 2018 Dec 20. Epub 2018 Dec 20.

Section of Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1007/s00467-018-4130-0DOI Listing
December 2018

Persistent fever in a pediatric renal transplant patient: Questions.

Pediatr Nephrol 2018 Dec 20. Epub 2018 Dec 20.

Section of Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1007/s00467-018-4126-9DOI Listing
December 2018

Haptoglobin degradation product as a novel serum biomarker for hematopoietic stem cell transplant-associated thrombotic microangiopathy.

Pediatr Nephrol 2018 Dec 19. Epub 2018 Dec 19.

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.

Background: Hematopoietic stem cell transplant (HSCT)-associated thrombotic microangiopathy (TA-TMA) is a well-known complication of HSCT and carries high risk of morbidity and mortality. A lack of consistent non-invasive diagnostic criteria can delay diagnosis and lead to irreversible organ damage.

Methods: Serum samples of 100 patients that underwent HSCT at Cincinnati Children's Hospital were serially collected. Read More

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http://link.springer.com/10.1007/s00467-018-4178-x
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http://dx.doi.org/10.1007/s00467-018-4178-xDOI Listing
December 2018
5 Reads

Renal stone and chronic kidney failure associated with hypouricemia: Answers.

Pediatr Nephrol 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatric Nephrology, School of Medicine, Akdeniz University, 07059, Antalya, Turkey.

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http://link.springer.com/10.1007/s00467-018-4170-5
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http://dx.doi.org/10.1007/s00467-018-4170-5DOI Listing
December 2018
10 Reads

A child with anemia, thrombocytopenia, renal failure and elevated amylase, and lipase enzymes: Answers.

Pediatr Nephrol 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatrics, Division of Nephrology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

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http://dx.doi.org/10.1007/s00467-018-4169-yDOI Listing
December 2018

Renal stone and chronic kidney failure associated with hypouricemia: Questions.

Pediatr Nephrol 2018 Dec 19. Epub 2018 Dec 19.

Department of Pediatric Nephrology, School of Medicine, Akdeniz University, 07059, Antalya, Turkey.

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http://dx.doi.org/10.1007/s00467-018-4163-4DOI Listing
December 2018

A child with anemia, thrombocytopenia, renal failure and elevated amylase, and lipase enzymes: Questions.

Pediatr Nephrol 2018 Dec 19. Epub 2018 Dec 19.

Division of Nephrology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

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http://dx.doi.org/10.1007/s00467-018-4159-0DOI Listing
December 2018
2 Reads

Rituximab therapy for refractory steroid-resistant nephrotic syndrome in children.

Pediatr Nephrol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pediatrics, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Patients with steroid-resistant nephrotic syndrome (SRNS) who develop resistance to immunosuppressive agents, defined as refractory SRNS, have poor renal outcomes. Although the chimeric anti-CD20 monoclonal antibody rituximab has shown efficacy for frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome, its efficacy for refractory SRNS remains uncertain due to limited data. According to previous case reports, 50. Read More

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http://link.springer.com/10.1007/s00467-018-4166-1
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http://dx.doi.org/10.1007/s00467-018-4166-1DOI Listing
December 2018
12 Reads

Low-dose rituximab is no less effective for nephrotic syndrome measured by 12-month outcome.

Pediatr Nephrol 2018 Dec 18. Epub 2018 Dec 18.

Department of Paediatric Nephrology, Royal Hospital for Children, 1345 Govan Road, Glasgow, G51 4TF, UK.

Objective: Rituximab is an effective treatment for children with steroid dependent or frequently relapsing nephrotic syndrome. The optimum dosing schedule for rituximab has not been established. We hypothesized that a single low dose of 375 mg/m would have comparable outcomes to higher doses in reducing the frequency of relapse and time to B cell reconstitution. Read More

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http://dx.doi.org/10.1007/s00467-018-4172-3DOI Listing
December 2018
1 Read

Chronic kidney disease following twin-to-twin transfusion syndrome-long-term outcomes.

Pediatr Nephrol 2018 Dec 17. Epub 2018 Dec 17.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.

Background: Amongst other sequelae, acute kidney injury (AKI) is a well-recognised post-natal complication of twin-to-twin transfusion syndrome (TTTS). Despite this, there has been a lack of data reporting long-term renal outcomes. Our aim was to report the long-term renal outcomes of infants born with TTTS. Read More

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http://dx.doi.org/10.1007/s00467-018-4176-zDOI Listing
December 2018
1 Read

Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H.

Pediatr Nephrol 2019 Mar 17;34(3):533-537. Epub 2018 Dec 17.

Pediatric Nephrology Unit, Bordeaux University Hospital, Bordeaux, France.

Background: Hemolytic uremic syndrome (HUS) has been associated with a number of infectious agents. We report here the case of an infant with severe Bordetella pertussis infection who developed HUS.

Case Diagnosis/treatment: A 2-month-old preterm male was admitted for severe Bordetella pertussis infection. Read More

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http://dx.doi.org/10.1007/s00467-018-4174-1DOI Listing
March 2019
2 Reads

Neurocognitive and functional outcomes at 5 years of age after renal transplant in early childhood.

Pediatr Nephrol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave, Edmonton, AB, T6G 1C9, Canada.

Background: Clinicians often use information about developmental outcomes in decision-making around offering complex, life-saving interventions in children such as dialysis and renal transplant. This information in children with end-stage renal disease (ESRD) is limited, particularly when ESRD onset is in infancy or early childhood.

Methods: Using data from an ongoing prospective, longitudinal, inception cohort study of children with renal transplant before 5 years of age, we evaluated (1) the risk of adverse neurocognitive and functional outcomes at 5 years of age and (2) predictors of developmental outcomes. Read More

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http://dx.doi.org/10.1007/s00467-018-4158-1DOI Listing
December 2018
1 Read

Metabolic requirements of the nephron.

Pediatr Nephrol 2018 Dec 15. Epub 2018 Dec 15.

Rangos Research Center, UPMC Children's Hospital of Pittsburgh, Pittsburgh, USA.

The mammalian kidney is a complex organ that has several metabolically active cell types to aid in waste filtration, salt-water balance, and electrolyte homeostasis in the body. These functions are done primarily through the nephron, which relies on strict regulation of various metabolic pathways. Any deviations in the metabolic profile of nephrons or their precursor cells called nephron progenitors can lead to renal pathologies and abnormal development. Read More

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http://link.springer.com/10.1007/s00467-018-4157-2
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http://dx.doi.org/10.1007/s00467-018-4157-2DOI Listing
December 2018
16 Reads

Functional roles of Grainyhead-like transcription factors in renal development and disease.

Pediatr Nephrol 2018 Dec 15. Epub 2018 Dec 15.

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125, Berlin, Germany.

Proper renal function relies on the tightly regulated development of nephrons and collecting ducts. This process, known as tubulogenesis, involves dynamic cellular and molecular changes that instruct cells to form highly organized tubes of epithelial cells which compartmentalize the renal interstitium and tubular lumen via assembly of a selective barrier. The integrity and diversity of the various renal epithelia is achieved via formation of intercellular protein complexes along the apical-basal axis of the epithelial cells. Read More

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http://link.springer.com/10.1007/s00467-018-4171-4
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http://dx.doi.org/10.1007/s00467-018-4171-4DOI Listing
December 2018
7 Reads

What's new in autoinflammation?

Authors:
Seza Ozen

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Hacettepe University, Ankara, Turkey.

The pathogenesis of autoinflammatory diseases has shed light on the concept of inflammation in general and on our understanding of the role of the innate immune system. The autoinflammatory diseases have a large spectrum with varying features of inflammation. The most common autoinflammatory diseases are those associated with periodic fevers. Read More

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http://dx.doi.org/10.1007/s00467-018-4155-4DOI Listing
December 2018
4 Reads

Growth plate alterations in chronic kidney disease.

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, CP 33006, Oviedo, Asturias, Spain.

Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. Read More

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http://dx.doi.org/10.1007/s00467-018-4160-7DOI Listing
December 2018
2 Reads

Five-year outcome of children with idiopathic nephrotic syndrome: the NEPHROVIR population-based cohort study.

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatric Nephrology, Hôpital Robert-Debré, APHP, 48 Bd Serurier, 75019, Paris, France.

Background: The optimal therapeutic regimen for children at onset of idiopathic nephrotic syndrome (INS) is still under debate. A better knowledge of the disease's course is necessary to design more appropriate and/or personalized treatment protocols.

Methods: We report the 5-year outcome of patients included from December 2007 to May 2010 in the prospective multicentric and multiethnic population-based NEPHROVIR study. Read More

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http://dx.doi.org/10.1007/s00467-018-4149-2DOI Listing
December 2018
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Idiopathic nephrotic syndrome and rituximab: may we predict circulating B lymphocytes recovery?

Pediatr Nephrol 2019 Mar 12;34(3):529-532. Epub 2018 Dec 12.

Pediatric Nephrology, Department of Pediatric Nephrology, Armand Trousseau Hospital, APHP, 26 Avenue du Docteur Arnold Netter, 75012, Paris, France.

Background: Rituximab (RTX) has been shown to be an efficient treatment for steroid-dependent nephrotic syndrome (SDNS). A long B cell depletion period seems to improve the duration of remission. This study reports the duration of B cell depletion after each RTX infusion in patients with nephrotic syndrome. Read More

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http://link.springer.com/10.1007/s00467-018-4139-4
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http://dx.doi.org/10.1007/s00467-018-4139-4DOI Listing
March 2019
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Diagnostics, treatment, and immune response in BK polyomavirus infection after pediatric kidney transplantation.

Pediatr Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric Kidney, Liver and Metabolic Disease, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.

After pediatric kidney transplantation BK polyomavirus (BKPyV) infections are associated with an increased risk of graft loss by BKPyV-associated nephropathy (BkPyVAN). However, suitable prognostic markers for the individual outcome of BKPyV infections are missing and the management of therapeutic interventions remains a challenge to the success of pediatric kidney transplantation. This review gives an overview on current diagnostic and therapeutic strategies in the field of BKPyV infections after pediatric kidney transplantation. Read More

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http://dx.doi.org/10.1007/s00467-018-4164-3DOI Listing
December 2018

Correction to: An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis.

Pediatr Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Children's Mercy Hospital, Kansas City, MO, USA.

The original version of this article unfortunately contained three mistakes. In Table 1, the last line under "Key Inclusion Criteria" should read "Normal or clinically acceptable ECGs at screening and at day - 1." In addition, the abbreviation "IP" in the legend to Table 1 stands for "investigational product. Read More

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http://dx.doi.org/10.1007/s00467-018-4154-5DOI Listing
December 2018
2 Reads

Renal mass in a 2-year-old girl: Answers.

Pediatr Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Dokuz Eylul University, Izmir, Turkey.

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http://dx.doi.org/10.1007/s00467-018-4146-5DOI Listing
December 2018
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Renal mass in a 2-year-old girl: Questions.

Pediatr Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatrics, Division of Nephrology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.

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http://dx.doi.org/10.1007/s00467-018-4141-xDOI Listing
December 2018