8,016 results match your criteria Pediatric nephrology[Journal]


Dominant PAX2 mutations may cause steroid-resistant nephrotic syndrome and FSGS in children.

Pediatr Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA.

Background: Heterozygous PAX2 mutations cause renal coloboma syndrome (RCS) [OMIM no. 120330]. RCS is a renal syndromic disease encompassing retinal coloboma and sensorineural hearing loss. Read More

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http://link.springer.com/10.1007/s00467-019-04256-0
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http://dx.doi.org/10.1007/s00467-019-04256-0DOI Listing
April 2019
1 Read

Variables of interest to predict glomerular filtration rate in preterm newborns in the first days of life.

Pediatr Nephrol 2019 Apr 18. Epub 2019 Apr 18.

Pediatric Nephrology Unit, Children and Adolescent Department, Children's Hospital, Geneva University Hospitals, 6 rue Willy Donzé CH-1211, Geneva 14, Switzerland.

Background: Measurement of neonatal renal function is challenging, and accurate, easy-to-use markers to estimate glomerular filtration rate (eGFR) are lacking. This study aimed to evaluate principal determinants of GFR in neonates and develop a predictive equation.

Methods: GFR was measured, using single injection inulin clearance, at median day 3 of life in 48 newborns. Read More

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http://dx.doi.org/10.1007/s00467-019-04257-zDOI Listing

Hemolytic uremic syndrome in a developing country: Consensus guidelines.

Pediatr Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Immunology, Hopital Europeen Georges Pompidou, INSERM UMRS 1138, Paris Descartes University, Paris, France.

Background: Hemolytic uremic syndrome (HUS) is a leading cause of acute kidney injury in children. Although international guidelines emphasize comprehensive evaluation and treatment with eculizumab, access to diagnostic and therapeutic facilities is limited in most developing countries. The burden of Shiga toxin-associated HUS in India is unclear; school-going children show high prevalence of anti-factor H (FH) antibodies. Read More

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http://link.springer.com/10.1007/s00467-019-04233-7
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http://dx.doi.org/10.1007/s00467-019-04233-7DOI Listing
April 2019
3 Reads

Association of low birth weight and prematurity with clinical outcomes of childhood nephrotic syndrome: a prospective cohort study.

Pediatr Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada.

Background: Low birth weight (LBW)/prematurity have been proposed as risk factors for the development of kidney disease in adulthood. Whether there is an association between LBW/prematurity and poor renal outcomes in childhood onset nephrotic syndrome remains unknown.

Methods: Children with nephrotic syndrome diagnosed between 1 and 18 years of age were followed prospectively from 1996 to 2016 at The Hospital for Sick Children (N = 377). Read More

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http://link.springer.com/10.1007/s00467-019-04255-1
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http://dx.doi.org/10.1007/s00467-019-04255-1DOI Listing
April 2019
2 Reads

Risk factors for early onset peritonitis: the SCOPE collaborative.

Pediatr Nephrol 2019 Apr 9. Epub 2019 Apr 9.

John's Hopkins Children's Center, Baltimore, MD, USA.

Background: Peritoneal dialysis (PD) is the preferred chronic dialysis modality amongst pediatric patients. Peritonitis is a devastating complication of PD. Adult data demonstrates early onset peritonitis (EP) is associated with higher rates of subsequent peritonitis and technique failure. Read More

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http://dx.doi.org/10.1007/s00467-019-04248-0DOI Listing
April 2019
1 Read

Treatment of infant formula with patiromer dose dependently decreases potassium concentration.

Pediatr Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA.

Background: Hyperkalemia is a potentially life-threatening complication of chronic kidney disease (CKD). Dietary potassium restriction is challenging in infants despite low-potassium formulas. Decreasing potassium in formula using patiromer, a new calcium-based cation exchange polymer may be one option to accomplish this; however, data confirming efficacy is lacking. Read More

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http://dx.doi.org/10.1007/s00467-019-04232-8DOI Listing
April 2019
1 Read

Glomerulonephritis and nephrotic syndrome in a child with DiGeorge syndrome: Answers.

Pediatr Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Wilf Children's Hospital, Pediatric Department, Shaare Zedek Medical Center, Shmuel Bait Street 12, 9103102, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s00467-019-04243-5DOI Listing
April 2019
1 Read

Association between BMI changes and mortality risk in children with end-stage renal disease.

Pediatr Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pediatrics, Division of Pediatric Nephrology, University of California San Francisco, San Francisco, CA, USA.

Background: Few studies have examined how changes in BMI [body mass index] over time associate with risk of adverse outcomes in children receiving renal replacement therapy [RRT]. The objective of this study was to examine the association between annualized changes in BMI and the risk of death in children treated with RRT.

Methods: We performed a retrospective cohort study of 1182 pediatric dialysis and transplant patients in the Pediatric Growth and Development Special Study of the United States Renal Data System. Read More

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http://dx.doi.org/10.1007/s00467-019-04249-zDOI Listing

Escherichia coli-associated hemolytic uremic syndrome and severe chronic hepatocellular cholestasis: complication or side effect of eculizumab?

Pediatr Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677, Bron, France.

Background: Liver lesions of hemolytic uremic syndrome due to Shiga-toxin-producing Escherichia coli (STEC-HUS) are uncommon.

Case-diagnosis/treatment: We report three observations of severe STEC-HUS with delayed hepatic involvement. They presented with multiple organ failure and received eculizumab; 15 days after the onset of STEC-HUS, cholestasis appeared and cytolysis worsened. Read More

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http://dx.doi.org/10.1007/s00467-019-04234-6DOI Listing
April 2019
3 Reads

Glomerulonephritis and nephrotic syndrome in a child with DiGeorge syndrome: Questions.

Pediatr Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Wilf Children's Hospital, Pediatric Department, Shaare Zedek Medical Center, Shmuel Bait Street 12, 9103102, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s00467-019-04242-6DOI Listing
April 2019
1 Read

Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study.

Pediatr Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland.

Background: Optimal treatment of Henoch-Schönlein purpura nephritis (HSN) remains unclear. We evaluated outcome of pediatric HSN patients treated initially with either methylprednisolone (MP) or cyclosporine A (CyA) in Finland between 1996 and 2011.

Methods: Outcome of 62 HSN patients was evaluated by screening urine and blood samples (n = 51) or by collecting clinical parameters from medical charts until last follow-up visit (n = 11). Read More

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http://dx.doi.org/10.1007/s00467-019-04238-2DOI Listing
April 2019
3 Reads

Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study.

Pediatr Nephrol 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatrics, Division of Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.

Background: Renal damage is a progressive complication of sickle cell disease (SCD). Microalbuminuria is common in children with SCD, while a smaller number of children have more severe renal manifestations necessitating kidney biopsy. There is limited information on renal biopsy findings in children with SCD and subsequent management and outcome. Read More

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http://dx.doi.org/10.1007/s00467-019-04237-3DOI Listing
April 2019
2 Reads

Association between the clinical presentation of congenital anomalies of the kidney and urinary tract (CAKUT) and gene mutations: an analysis of 66 patients at a single institution.

Pediatr Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: The association between the clinical presentation of congenital anomalies of the kidney and urinary tract (CAKUT) and gene mutations has yet to be fully explored.

Methods: In this retrospective cohort study, we examined patients with CAKUT who underwent gene analysis. The analysis was performed in patients with bilateral renal lesions, extrarenal complications, or a family history of renal disease. Read More

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http://dx.doi.org/10.1007/s00467-019-04230-wDOI Listing
April 2019
2 Reads

Voiding cystography: an unusual route of induced hypothyroidism by iodine overdose in two newborns with chronic kidney disease.

Pediatr Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Pediatric Nephrology Unit, Robert Debré University Hospital - APHP, Paris, France.

Background: Iatrogenic induced hypothyroidism had been described in newborns and more particularly in preterm infants after cutaneous or intravenous exposure to iodine. CASE-DIAGNOSIS : We reported a new risk of iodine intoxication with the cases of two newborns who developed hypothyroidism after intra vesical iodine injection during a cystography, which was performed to confirm antenatal diagnosis of posterior urethral valves (PUV). The newborns both developed transient hypothyroidism due to an iodine overdose. Read More

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http://dx.doi.org/10.1007/s00467-019-04247-1DOI Listing
April 2019
3 Reads

Why 0.9% saline is not normal.

Authors:
Mehdi Rasouli

Pediatr Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Department of Clinical Biochemistry and Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

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http://dx.doi.org/10.1007/s00467-019-04245-3DOI Listing
April 2019
2.856 Impact Factor

Body composition and arterial stiffness in pediatric patients with chronic kidney disease.

Pediatr Nephrol 2019 Mar 29. Epub 2019 Mar 29.

1st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, 49 Konstantinoupoleos Street, 54642, Thessaloniki, Greece.

Background: This study investigated the impact of body composition in the arterial stiffness of children with chronic kidney disease (CKD).

Methods: Fat mass (FM), fat tissue index (FTI), fat-free mass (FFM), fat-free tissue index (FFTI), and FFTI/FTI were measured in 26 patients and 25 healthy controls by bio-impedance analysis. Data on patient's body mass index (BMI) for height-age, serum albumin, glomerular filtration rate (GFR), blood pressure status, and pulse wave velocity (PWV) were collected in patients. Read More

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http://dx.doi.org/10.1007/s00467-019-04224-8DOI Listing
March 2019
4 Reads

Lineage-specific roles of hedgehog-GLI signaling during mammalian kidney development.

Pediatr Nephrol 2019 Mar 28. Epub 2019 Mar 28.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A8, Canada.

Aberrant hedgehog (Hh) signaling during embryogenesis results in various severe congenital abnormalities, including renal malformations. The molecular mechanisms that underlie congenital renal malformations remain poorly understood. Here, we review the current understanding of the lineage-specific roles of Hh signaling during renal morphogenesis and how aberrant Hh signaling during embryonic kidney development contributes to renal malformation. Read More

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http://link.springer.com/10.1007/s00467-019-04240-8
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http://dx.doi.org/10.1007/s00467-019-04240-8DOI Listing
March 2019
3 Reads

Iodine excess in children with kidney disease: are we missing hypothyroidism?

Authors:
Lesley Rees

Pediatr Nephrol 2019 Mar 26. Epub 2019 Mar 26.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.

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http://dx.doi.org/10.1007/s00467-019-04246-2DOI Listing

Response to "Predictors of rituximab-related neutropenia in Japanese children with steroid-dependent nephrotic syndrome".

Pediatr Nephrol 2019 Mar 26. Epub 2019 Mar 26.

Department of Pediatric Nephrology, Armand-Trousseau Hospital, APHP, 26, Avenue du Docteur Arnold Netter, 75012, Paris, France.

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http://dx.doi.org/10.1007/s00467-019-04239-1DOI Listing
March 2019
1 Read

Treatment of nephrotic syndrome: going beyond immunosuppressive therapy.

Pediatr Nephrol 2019 Mar 23. Epub 2019 Mar 23.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

It is indisputable that immunosuppressive therapy and pathological diagnosis of renal biopsy have greatly improved the prognosis of childhood nephrotic syndrome. Unfortunately, there is no "one-size-fits-all" approach for precise patient stratification and treatment when facing the huge challenges posed by steroid-resistant nephrotic syndrome (SRNS). But genomic medicine has brought a glimmer of light, and the cognition of SRNS has entered a new stage. Read More

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http://dx.doi.org/10.1007/s00467-019-04225-7DOI Listing
March 2019
1 Read

Cardiovascular disease risk among children with focal segmental glomerulosclerosis: a report from the chronic kidney disease in children study.

Pediatr Nephrol 2019 Mar 22. Epub 2019 Mar 22.

Division of Pediatric Nephrology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: The aims were to compare the cardiovascular disease (CVD) risk among children with chronic kidney disease (CKD) secondary to focal segmental glomerulosclerosis (FSGS) with the CVD risk of children with CKD due to other diagnoses.

Methods: Casual blood pressure (BP), ambulatory blood pressure monitoring (APBM), echocardiogram, lipids, carotid intima medial thickness (cIMT), and uric acid obtained from participants in the Chronic Kidney Disease in Children (CKiD) cohort were analyzed longitudinally. Seventy-nine children with FSGS (FSGS-CKD) were compared to 196 children with non-FSGS glomerular disease (GDO-CKD) and 616 children with non-glomerular disease (NG-CKD). Read More

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http://dx.doi.org/10.1007/s00467-019-04229-3DOI Listing
March 2019
1 Read

Mild hypotonia and recurrent seizures in an 8-month-old boy: Answers.

Pediatr Nephrol 2019 Mar 22. Epub 2019 Mar 22.

Faculty of Medicine, Department of Pediatric Neurology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

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http://link.springer.com/10.1007/s00467-019-04236-4
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http://dx.doi.org/10.1007/s00467-019-04236-4DOI Listing
March 2019
3 Reads

Mild hypotonia and recurrent seizures in an 8-month-old boy: Questions.

Pediatr Nephrol 2019 Mar 22. Epub 2019 Mar 22.

Faculty of Medicine, Department of Pediatric Neurology, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

Hypomagnesemia with secondary hypocalcemia is a rare autosomal recessive disorder which manifests in early infancy with generalized seizures, other symptoms of neuromuscular irritability, and growth disturbances. Homozygous mutations in the magnesium transporter gene, transient receptor potential melastatin 6 (TRPM6), cause the disease. Here, we present an 8-month-old Turkish boy with a novel mutation of TRPM6. Read More

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http://dx.doi.org/10.1007/s00467-019-04231-9DOI Listing
March 2019
4 Reads

Using urine nitrite sticks to test for urinary tract infection in children aged < 2 years: a meta-analysis.

Pediatr Nephrol 2019 Mar 20. Epub 2019 Mar 20.

Great North Children's Hospital, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.

Background: This study aimed to determine whether nitrite sticks are as sensitive at detecting urinary tract infection (UTI) in children <2 years as they are in older children.

Methods: I reanalysed data on using nitrite sticks to detect UTIs for children aged either < 2 or 2-18 years. For sensitivity, evidence of a UTI was defined as level 1 when a single uropathogen grew ≥ 10 colony forming units/ml (cfu/ml) in two urine samples, level 2 when just one sample was cultured or a threshold of < 10 cfu/ml was used, and level 3 if mixed growths or Staphylococcus albus was considered to be positive. Read More

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http://dx.doi.org/10.1007/s00467-019-04226-6DOI Listing

Psychosocial considerations and recommendations for care of pediatric patients on dialysis.

Pediatr Nephrol 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatrics, Psychology Section, Baylor College of Medicine/Texas Children's Hospital, 1102 Bates Ave., Ste. 245, Houston, TX, 77030, USA.

Dialysis treatment has evolved to enable children to live longer and transition to adulthood. Thus, the focus of care shifts to a consideration of pediatric patients' quality of life and psychosocial functioning across childhood, adolescence, and young adulthood. Despite well-documented concerns in various domains (including depression/anxiety, self-esteem and social functioning, behavior problems, and academic and cognitive functioning), limited literature exists regarding psychosocial guidelines for children and adolescents undergoing dialysis. Read More

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http://dx.doi.org/10.1007/s00467-019-04227-5DOI Listing
March 2019
2 Reads

Predictors of rituximab-related neutropenia in Japanese children with steroid-dependent nephrotic syndrome.

Pediatr Nephrol 2019 Mar 18. Epub 2019 Mar 18.

Division of Nephrology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuo-ku, Saitama City, Saitama, 330-8777, Japan.

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http://dx.doi.org/10.1007/s00467-019-04235-5DOI Listing
March 2019
3 Reads

Dialysis modalities for the management of pediatric acute kidney injury.

Pediatr Nephrol 2019 Mar 18. Epub 2019 Mar 18.

Division of Nephrology and Dialysis, Department of Pediatrics, Bambino Gesù Children's Hospital and Research Institute, Piazza Sant'Onofrio 4, 00165, Rome, Italy.

Acute kidney injury (AKI) is an increasingly frequent complication among hospitalized children. It is associated with high morbidity and mortality, especially in neonates and children requiring dialysis. The different renal replacement therapy (RRT) options for AKI have expanded from peritoneal dialysis (PD) and intermittent hemodialysis (HD) to continuous RRT (CRRT) and hybrid modalities. Read More

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http://dx.doi.org/10.1007/s00467-019-04213-xDOI Listing
March 2019
1 Read

Clinical course of hantavirus-induced nephropathia epidemica in children compared to adults in Germany-analysis of 317 patients.

Pediatr Nephrol 2019 Mar 14. Epub 2019 Mar 14.

Department of Nephrology, Klinikum Stuttgart, Kriegsbergstraße 60, 70174, Stuttgart, Germany.

Background: Hantavirus infections are endemic worldwide, and its incidence in Europe has been steadily increasing. In Western Europe, hantavirus infections are typically caused by Puumala hantavirus and cause nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome. Up to now, there is only little data about the course of acute NE in children, but it has been suggested that hantavirus infections take a lighter course in children when compared to adults. Read More

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http://dx.doi.org/10.1007/s00467-019-04215-9DOI Listing
March 2019
1 Read

Nephrotic syndrome and mitochondrial disorders: answers.

Pediatr Nephrol 2019 Mar 12. Epub 2019 Mar 12.

Unité de néphrologie pédiatrique, CHU de Nice - Hôpital Archet, 151 Route de Saint-Antoine de Ginestière, B.P. 23079, 06202, Nice Cedex 3, France.

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http://dx.doi.org/10.1007/s00467-019-04217-7DOI Listing
March 2019
5 Reads

Nephrotic syndrome and mitochondrial disorders: Questions.

Pediatr Nephrol 2019 Mar 12. Epub 2019 Mar 12.

Unité de néphrologie pédiatrique, CHU de Nice - Hôpital Archet 2, 151 Route de Saint-Antoine de Ginestière, B.P. 23079, 06202, Nice Cedex 3, France.

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http://dx.doi.org/10.1007/s00467-019-04216-8DOI Listing
March 2019
1 Read

Prevalence of low molecular weight proteinuria and Dent disease 1 CLCN5 mutations in proteinuric cohorts.

Pediatr Nephrol 2019 Mar 10. Epub 2019 Mar 10.

Rare Kidney Stone Consortium, Rochester, USA.

Background: Dent disease type 1 (DD1) is a rare X-linked disorder caused mainly by CLCN5 mutations. Patients may present with nephrotic-range proteinuria leading to erroneous diagnosis of focal segmental glomerulosclerosis (FSGS) and unnecessary immunosuppressive treatments.

Methods: The following cohorts were screened for CLCN5 mutations: Chronic Kidney Disease in Children (CKiD; n = 112); Multicenter FSGS-Clinical Trial (FSGS-CT) (n = 96), and Novel Therapies for Resistant FSGS Trial (FONT) (n = 30). Read More

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http://dx.doi.org/10.1007/s00467-019-04210-0DOI Listing
March 2019
2 Reads

The pathogenesis and management of renal scarring in children with vesicoureteric reflux and pyelonephritis.

Pediatr Nephrol 2019 Mar 7. Epub 2019 Mar 7.

Montreal Childrens Hospital, Montreal, Quebec, Canada.

Bacterial urinary tract infections (UTIs) are one of the most common reasons for children to be admitted to hospital. Bacteria infect and invade the bladder (the lower urinary tract) and if the infection disseminates to the upper urinary tract, significant inflammation in the kidneys may arise. Inflammation is a double-edged sword: it is needed to clear bacteria, but if excessive, kidney tissue is injured. Read More

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http://link.springer.com/10.1007/s00467-018-4187-9
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http://dx.doi.org/10.1007/s00467-018-4187-9DOI Listing
March 2019
7 Reads

Clostridium difficile infection after pediatric solid organ transplantation: a practical single-center experience.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

University Children's Medical Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: During the last two decades, there has been a worldwide increase in frequency and severity of infections with Clostridium difficile (CDI). Solid organ transplant (SOT) recipients receiving immunosuppressing medications are especially at risk.

Methods: We collected data from immunocompromised pediatric patients, including kidney and liver transplant recipients, at our tertiary pediatric care center in Germany. Read More

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http://dx.doi.org/10.1007/s00467-019-04219-5DOI Listing
March 2019
5 Reads

Feeding modality is a barrier to adequate protein provision in children receiving continuous renal replacement therapy (CRRT).

Pediatr Nephrol 2019 Jun 6;34(6):1147-1150. Epub 2019 Mar 6.

Sections of Nephrology, Department of Pediatrics, Baylor College of Medicine, 1102 Bates Street, Suite 245, Houston, TX, 77033, USA.

Background: Critically ill children have a high prevalence of malnutrition. Children with acute kidney injury experience high rates of protein debt. Previous research has indicated that protein provision is positively associated with survival. Read More

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http://dx.doi.org/10.1007/s00467-019-04211-zDOI Listing
June 2019
2 Reads

Glomerular disease patients have higher odds not to reach quality targets in chronic dialysis compared with CAKUT patients: analyses from a nationwide German paediatric dialysis registry.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Background: Paediatric dialysis patients still suffer from high morbidity rates. To improve this, quality assurance programs like the German QiNKid (Quality in Nephrology for Children)-Registry have been developed. In our study, the significance of underlying renal disease on a range of clinical and laboratory parameters impacting morbidity and mortality was analysed. Read More

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http://dx.doi.org/10.1007/s00467-019-04218-6DOI Listing
March 2019
1 Read

An adolescent patient presenting with hyponatremic seizure: Answers.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pediatric Nephrology, Dokuz Eylül University Medical Faculty, 35340, Balçova, İzmir, Turkey.

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http://link.springer.com/10.1007/s00467-019-04214-w
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http://dx.doi.org/10.1007/s00467-019-04214-wDOI Listing
March 2019
6 Reads

Proteinuria in a patient with Graves' disease: Answers.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pediatric Endocrinology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34098, Fatih, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-04221-xDOI Listing
March 2019
1 Read

Transitioning adolescents to adult nephrology care: a systematic review of the experiences of adolescents, parents, and health professionals.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Monash Nursing and Midwifery, Monash University, Clayton, Victoria, Australia.

A challenging phase for adolescents with chronic kidney disease (CKD) is the transition from a pediatric to an adult health service. Failure to adequately prepare adolescents for transfer to adult care can lead to a decline in attendance to the adult clinic and an increase in the rate of non-adherence to medical treatment. The aim of this systematic review was to analyze studies exploring the experiences of adolescents, parents, and health professionals regarding the transition process of adolescents with CKD. Read More

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http://dx.doi.org/10.1007/s00467-019-04223-9DOI Listing
March 2019
1 Read

Proteinuria in a patient with Graves' disease: Questions.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pediatric Endocrinology, Cerrahpasa Faculty of Medicine, Istanbul University- Cerrahpasa, 34098, Fatih, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-04220-yDOI Listing
March 2019
5 Reads

An adolescent patient presenting with hyponatremic seizure: Questions.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pediatric Nephrology, Dokuz Eylül University Medical Faculty, 35340, Balçova, İzmir, Turkey.

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http://dx.doi.org/10.1007/s00467-019-04212-yDOI Listing
March 2019
1 Read

Radiographic abnormalities, bladder interventions, and bladder surgery in the first decade of life in children with spina bifida.

Pediatr Nephrol 2019 Mar 3. Epub 2019 Mar 3.

Division of Pediatric Urology, Indiana University School of Medicine, 535 Barnhill Drive, Suite 150, Indianapolis, IN, 46202, USA.

Background: Spina bifida (SB) patients are at increased risk for hydronephrosis, bladder storage and emptying problems, and renal failure that may require multiple bladder surgeries.

Methods: We retrospectively reviewed patients born with SB 2005-2009, presenting to our institution within 1 year of birth. Outcomes at 8-11 years old included final renal/bladder ultrasound (RBUS) results, clean intermittent catheterization (CIC) use, anticholinergic use, surgical interventions, and final renal function. Read More

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http://dx.doi.org/10.1007/s00467-019-04222-wDOI Listing
March 2019
1 Read

Asymptomatic bacteriuria in pediatric kidney transplant recipients: to treat or not to treat? A retrospective study.

Pediatr Nephrol 2019 Jun 28;34(6):1141-1145. Epub 2019 Feb 28.

Pediatric Nephrology Department, Robert Debré Hospital, 48 boulevard Sérurier, 75019, Paris, France.

Background: Urinary tract infections (UTI) are common infectious complications in kidney transplant recipients (KTR); asymptomatic bacteriuria (AB) is also frequent. It is unclear whether treatment of AB reduces subsequent UTI in KTR; no guideline is available in pediatric KTR. In this retrospective study, we analyzed the incidence of AB in pediatric KTR and the impact of screening and treating AB on the onset of subsequent UTI. Read More

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http://dx.doi.org/10.1007/s00467-019-04204-yDOI Listing
June 2019
3 Reads

Nephrotic syndrome in a dish: recent developments in modeling in vitro.

Pediatr Nephrol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.

Nephrotic syndrome is a heterogeneous disease, and one of the most frequent glomerular disorders among children. Depending on the etiology, it may result in end-stage renal disease and the need for renal replacement therapy. A dysfunctional glomerular filtration barrier, comprising of endothelial cells, the glomerular basement membrane and podocytes, characterizes nephrotic syndrome. Read More

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http://dx.doi.org/10.1007/s00467-019-4203-8DOI Listing
February 2019
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Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways.

Authors:
Allison A Eddy

Pediatr Nephrol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, Canada.

More than 250 drugs carry a small but important dose-independent risk of initiating a delayed-type hypersensitivity reaction that leads to acute tubulointerstitial nephritis (TIN). Clinical manifestations are often non-specific, making epidemiological studies challenging. In severe cases, if cessation of the offending drug is not followed by a prompt improvement in renal function, corticosteroid therapy appears to enhance renal recovery rates. Read More

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http://link.springer.com/10.1007/s00467-019-04207-9
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http://dx.doi.org/10.1007/s00467-019-04207-9DOI Listing
February 2019
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Maternal and gestational influences on childhood blood pressure.

Authors:
Bonita Falkner

Pediatr Nephrol 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine and Pediatrics, Thomas Jefferson University, 833 Chestnut St. Ste. 7000, Philadelphia, PA, 19107, USA.

Exposures that contribute to a sub-optimal intrauterine environment can have an effect on the developing fetus. Impaired fetal growth that results in low birth weight is an established risk factor for cardio-metabolic disorders later in life. Recent epidemiologic and prospective cohort studies that include the maternal and gestational period have identified maternal and gestational conditions that confer increased risk for subsequent cardio-metabolic disorders in the absence of low birth weight. Read More

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http://dx.doi.org/10.1007/s00467-019-4201-xDOI Listing
February 2019
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A child with bilateral multiple renal cysts presenting with ascites and pleural effusion: Answers.

Pediatr Nephrol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Haseki Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-4198-1DOI Listing
February 2019
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A child with bilateral multiple renal cysts presenting with ascites and pleural effusion: Questions.

Pediatr Nephrol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Haseki Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-4196-3DOI Listing
February 2019
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The association between socioeconomic disadvantage and parent-rated health in children and adolescents with chronic kidney disease-the Kids with CKD (KCAD) study.

Pediatr Nephrol 2019 Feb 20. Epub 2019 Feb 20.

Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Objective: To determine the association of socioeconomic disadvantage and parent-rated health in children with chronic kidney disease (CKD).

Methods: A total of 377 children (aged 6-18 years) with CKD stages I-V (n = 199), on dialysis (n = 43), or with a kidney transplant (n = 135) were recruited from 2012 to 2016 in Australia and New Zealand. Associations of five socioeconomic status (SES) components and the global SES index with parent-rated health of the child were examined using adjusted logistic regression. Read More

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http://dx.doi.org/10.1007/s00467-019-04209-7DOI Listing
February 2019
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The population-based prevalence of hypertension and correlates of blood pressure among Australian children.

Pediatr Nephrol 2019 Jun 18;34(6):1107-1115. Epub 2019 Feb 18.

School of Public Health, University of Sydney, Sydney, New South Wales, Australia.

Objective: Hypertension is increasingly recognized as a disease spanning the entire life course. Continued efforts to refine the diagnosis and management of hypertension in children are highlighted by the recent American Academy of Pediatrics (AAP) guidelines, which include lower threshold values than the previous reference standard (Fourth Report). We aimed to determine the population-based prevalence of children exceeding thresholds for hypertension using these two guidelines. Read More

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http://link.springer.com/10.1007/s00467-019-04206-w
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http://dx.doi.org/10.1007/s00467-019-04206-wDOI Listing
June 2019
3 Reads