1,734 results match your criteria Pediatric and Developmental Pathology [Journal]


A Case of Fulminant Bacillus cereus Lung Necrosis in a Preterm Neonate.

Pediatr Dev Pathol 2019 Feb 13:1093526619825895. Epub 2019 Feb 13.

5 Department of Pathology and Laboratory Medicine, The Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Bacillus cereus is a ubiquitous Gram-positive rod seldom considered pathogenic in clinical isolates. However, it possesses multiple virulence factors explaining why it has been linked to fulminant and pyogenic infections in vulnerable hosts. Its recovery from sterile samples in immunocompromised patients cannot be disregarded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619825895DOI Listing
February 2019

Focal Chorangiosis: Does It Have Clinical and Pathologic Significance?

Pediatr Dev Pathol 2019 Feb 13:1093526619830866. Epub 2019 Feb 13.

1 Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Introduction: Chorangiosis is a proliferation of capillaries in terminal chorionic villi and is considered to be a marker for hypoxia and poor clinical outcome. Not all cases with hypervascular villi meet the generally accepted diagnostic criteria as reported by Altshuler. Our aim was to evaluate cases with villous hypervascularity that do not meet the diagnosis of chorangiosis, in which increased vascularity was present in a significant portion of the villous tissue but was not a diffuse process, which we call focal chorangiosis, to ascertain whether there were clinical or pathologic associations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619830866DOI Listing
February 2019

Lingual Alveolar Soft Part Sarcoma in a 1-Year-Old Infant: Youngest Reported Case With Characteristic ASPSCR1-TFE3 Fusion.

Pediatr Dev Pathol 2019 Feb 11:1093526619830290. Epub 2019 Feb 11.

1 Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Alveolar soft part sarcoma (ASPS) is an exceptionally rare non-rhabdomyosarcomatous soft tissue sarcoma (NRSTS), characterized by the translocation t(X;17) p(11.2;q25). This translocation results in the chimeric ASPSCR1-TFE3 transcription factor which drives tumorigenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619830290DOI Listing
February 2019

Extrahepatic Nonreticuloendothelial Siderosis Is Not Specific to Gestational Alloimmune Liver Disease.

Pediatr Dev Pathol 2019 Feb 5:1093526619826429. Epub 2019 Feb 5.

1 Department of Pathology, Texas Children's Hospital, Houston, Texas.

Autopsy reports of 78 stillbirths and early infant deaths (up to age 8 weeks) were reviewed to investigate the prevalence of extrahepatic nonreticuloendothelial siderosis (EHNRS) in the context of neonatal liver failure. Of these, 10 liveborns (12.8%), M:F 3:2, with mean gestational age 37. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619826429DOI Listing
February 2019
2 Reads

Fractal Dimension Does Not Correlate As Well With Models of Neonatal Chronic Lung Injury as It Does With Placental Distal Villous Hypoplasia.

Pediatr Dev Pathol 2019 Feb 2:1093526618782499. Epub 2019 Feb 2.

3 Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618782499DOI Listing
February 2019

Rapid Alterations in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by MALDI-Mass Spectrometry.

Pediatr Dev Pathol 2019 Jan 25:1093526619826721. Epub 2019 Jan 25.

1 Department of Medicine, Rhode Island Hospital, Providence, Rhode Island.

Background: Perinatal ischemia-reperfusion (I/R) injury of cerebral white matter causes long-term cognitive and motor disabilities in children. I/R damages or kills highly metabolic immature oligodendroglia via oxidative stress, excitotoxicity, inflammation, and mitochondrial dysfunction, impairing their capacity to generate and maintain mature myelin. However, the consequences of I/R on myelin lipid composition have not been characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619826721DOI Listing
January 2019
1 Read

Pathophysiological Mechanism of Extravasation via Umbilical Venous Catheters.

Pediatr Dev Pathol 2019 Jan 25:1093526619826714. Epub 2019 Jan 25.

2 Neonatal Unit, Birmingham Women's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

A rare complication of umbilical venous catheter (UVC) insertion is the extravasation of the infusate into the peritoneal cavity. We report 3 cases of abdominal extravasation of parenteral nutrition (PN) fluid via UVCs. Two of these cases presented as "acute abdomen" which were assumed to be necrotizing enterocolitis clinically; however, during postmortem, PN ascites and liver necrosis were found. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619826714DOI Listing
January 2019
2 Reads

Noonan Syndrome Case Report: PTPN11 and Other Potential Genetic Factors Contributing to Lethal Hypertrophic Right Ventricular Cardiomyopathy.

Pediatr Dev Pathol 2019 Jan 21:1093526618825411. Epub 2019 Jan 21.

1 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Noonan syndrome is a genetic condition with a heterogeneous phenotype and multisystem involvement. The pathogenesis of this disorder has been attributed to the mutations in the RAS/MAPK signaling pathway involved in cell proliferation and differentiation. The most common clinical presentations are related to cardiovascular abnormalities with congestive heart failure as the most common mechanism of death. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618825411
Publisher Site
http://dx.doi.org/10.1177/1093526618825411DOI Listing
January 2019
5 Reads

Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta.

Pediatr Dev Pathol 2019 Jan 21:1093526619825708. Epub 2019 Jan 21.

1 Division of Surgical Pathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.

Background: Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that disorders of the placental basal plate, especially basal chronic villitis (BCV), are associated with HDP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526619825708DOI Listing
January 2019
2 Reads

Early Bilateral Gonadoblastoma Associated With 45,X/46,XY Mosaicism: The Spectrum of Undifferentiated Gonadal Tissue and Gonadoblastoma in the First Months of Life.

Pediatr Dev Pathol 2019 Jan 15:1093526618824469. Epub 2019 Jan 15.

2 Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

45,X/46,XY mosaicism is one of a heterogenous group of congenital conditions known as differences (disorders) of sex development (DSD) that results in abnormal development of internal and external genitalia. Patients with DSD, particularly those with segments of the Y chromosome, are at increased risk for germ cell tumors including gonadoblastoma. Gonadoblastoma is a neoplasm comprised of a mixture of germ cells and elements resembling immature granulosa or Sertoli cells with or without Leydig cells or lutein-type cells in an ovarian type stroma. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618824469
Publisher Site
http://dx.doi.org/10.1177/1093526618824469DOI Listing
January 2019
3 Reads
0.857 Impact Factor

Neuroblastoma of the Bone and Bone Marrow Without an Apparent Primary Site: Report of 4 Cases With Long-term Follow-up.

Pediatr Dev Pathol 2019 Jan 2:1093526618822597. Epub 2019 Jan 2.

1 Division of Hematology-Oncology, Department of Pediatrics, Texas Children's Cancer & Hematology Centers, Baylor College of Medicine, Houston, Texas.

Children with neuroblastoma rarely present with metastatic disease without identifiable primary tumors. We describe the clinical and histopathologic characteristics of 4 patients aged 1, 7, 7, and 11 years with neuroblastoma involving bone or bone marrow without an apparent primary site. One patient presented with a periorbital bone lesion, 1 presented with a distal femoral lesion, and 2 presented with diffuse bone marrow involvement. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618822597
Publisher Site
http://dx.doi.org/10.1177/1093526618822597DOI Listing
January 2019
2 Reads

Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy.

Pediatr Dev Pathol 2019 Jan 2:1093526618822108. Epub 2019 Jan 2.

9 Division of Hematology Oncology, Boston Children's Hospital, Boston, Massachusetts.

Germline mutations in RUNX1 result in autosomal dominant familial platelet disorder with associated myeloid malignancy (FPDMM). To characterize the hematopathologic features associated with a germline RUNX1 mutation, we reviewed a total of 42 bone marrow aspirates from 14 FPDMM patients, including 24 cases with no cytogenetic clonal abnormalities, and 18 with clonal karyotypes or leukemia. We found that all aspirate smears had ≥10% atypical megakaryocytes, predominantly characterized by small forms with hypolobated and eccentric nuclei, and forms with high nuclear-to-cytoplasmic ratios. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618822108DOI Listing
January 2019
8 Reads

A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation.

Pediatr Dev Pathol 2018 Dec 21:1093526618819605. Epub 2018 Dec 21.

1 Division of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, California.

Precocious puberty in an infant is an alarming and infrequent finding, making the differential diagnosis difficult for practitioners. Precocious puberty secondary to a sclerosing stromal tumor (SST) of the ovary is rare. We present a case of a child that began precocious puberty at 3 months of age including development of breast buds, pubic hair, growth spurt, and menarche 5 days prior to presenting to pediatric endocrinology at 10 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618819605DOI Listing
December 2018

Kidney Biopsy Findings in a Patient With Valproic Acid-Associated Fanconi Syndrome.

Pediatr Dev Pathol 2018 Dec 19:1093526618819334. Epub 2018 Dec 19.

2 Department of Pathology, Zucker School of Medicine, Hofstra University, Hempstead, New York.

A 7-year-old boy with a history of febrile illness-related epilepsy syndrome presented with proteinuria and elevated creatinine. His severe epileptic disorder has been treated since age 2 with multiple antiepileptic medications, including valproic acid. More recently, he was noted to have features of Fanconi syndrome with acidosis, hypophosphatemia, hypokalemia, glucosuria, and nephrotic-range proteinuria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618819334DOI Listing
December 2018
1 Read

Atypical Prenatal Ultrasound Presentation and Neuropathological Findings in a Neonate With Alpha Thalassemia Major: A Case Report.

Pediatr Dev Pathol 2018 Dec 14:1093526618817655. Epub 2018 Dec 14.

1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.

Alpha thalassemia major is a hemoglobinopathy caused by the inactivation or deletion of all 4 α-globin alleles. We describe a case of α-thalassemia major with atypical ultrasound and neuropathological findings. The mother had her first prenatal visit at 27 4/7 gestational weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618817655DOI Listing
December 2018
1 Read

Remodeling of Rectal Innervation After Pullthrough Surgery for Hirschsprung Disease: Relevance to Criteria for the Determination of Retained Transition Zone.

Pediatr Dev Pathol 2018 Dec 12:1093526618817658. Epub 2018 Dec 12.

7 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: After pullthrough surgery for Hirschsprung disease (HSCR), Glut1-positive submucosal nerve hypertrophy is used to diagnose retained transition zone in the neorectum. We hypothesized that pelvic nerves, severed during pullthrough surgery, sprout into the neorectum to mimic transition zone.

Methods: The density (nerves/100x field) and maximum diameter of Glut1-positive submucosal nerves were measured in biopsies and redo resections from 20 patients with post-pullthrough obstructive symptoms. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618817658
Publisher Site
http://dx.doi.org/10.1177/1093526618817658DOI Listing
December 2018
4 Reads

Changes in the Prevalence of Embryologic Remnants in Umbilical Cord With Gestational Age.

Pediatr Dev Pathol 2018 Dec 12:1093526618813663. Epub 2018 Dec 12.

2 Department of Clinical Genetics, Lund University, Lund, Sweden.

The aim of this study was to examine the prevalence of embryologic remnants in umbilical cords of different gestational ages. Sections from 392 umbilical cords were examined using light microscopy. Of these, 52% contained at least 1 remnant, most commonly of the allantoic duct type. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618813663DOI Listing
December 2018

Prevalence, Morphology, Embryogenesis, and Diagnostic Utility of Umbilical Cord Vitelline Vascular Remnants.

Authors:
James R Wright

Pediatr Dev Pathol 2018 Dec 12:1093526618811734. Epub 2018 Dec 12.

1 Department of Pathology & Laboratory Medicine, University of Calgary/Calgary Laboratory Services, Alberta Children's Hospital, Calgary, Alberta, Canada.

The objective of this study is to better understand embryonic vitelline vascular remnants in the umbilical cord, to assess their prevalence, to categorize their morphology, and then finally to describe and assess inflammation arising from these structures. During routine placental sign out, the author noted the presence or absence of vitelline vessel remnants for 1 year; when present, he assessed their histologic patterns and noted whether there were neutrophils marginating from the remnants and into the adjacent Wharton's jelly and whether there was any other evidence of amniotic fluid infection in sections of placental disc, membranes, or cord. All cord sections with vitelline vessel remnants were immunostained for CD15 to document any infiltrates, to highlight patterns of infiltration, and to evaluate whether mild cases of umbilical phlebitis were associated with these lesions and were at risk of being missed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618811734DOI Listing
December 2018
1 Read

Atypical Hepatic Mesenchymal Hamartoma: Histologic Appearance, Immunophenotype, and Molecular Findings.

Pediatr Dev Pathol 2018 Nov 29:1093526618806750. Epub 2018 Nov 29.

9 Department of Pediatric Surgery, Children's Hospital of Eastern Ontario and University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.

Hepatic mesenchymal hamartoma is a rare benign neoplasm principally encountered in young children. Its origin is unknown. We report an unusual hepatic mesenchymal hamartoma in a 7-month-old girl, including histopathologic findings, immunophenotype, and karyotype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618806750DOI Listing
November 2018
2 Reads
0.857 Impact Factor

2018 SPP Fall Abstracts.

Authors:

Pediatr Dev Pathol 2018 Nov 27:1093526618806423. Epub 2018 Nov 27.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618806423DOI Listing
November 2018

Spontaneous Regression of Atypical Teratoid Rhabdoid Tumor Without Therapy in a Patient With Uncommon Regional Inactivation of SMARCB1 ( hSNF5/INI1).

Pediatr Dev Pathol 2018 Nov 23:1093526618814696. Epub 2018 Nov 23.

3 Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas.

Atypical teratoid/rhabdoid tumor (ATRT) is a high-grade central nervous system tumor, with poor prognosis despite intensive multimodal therapy. Loss of nuclear immunostaining for INI1 due to inactivation of the hSNF5/INI1 tumor suppressor gene is pathognomonic of ATRT. We present a patient with congenital ATRT, who had spontaneous tumor regression without therapy, and is disease-free 4 years later. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618814696
Publisher Site
http://dx.doi.org/10.1177/1093526618814696DOI Listing
November 2018
2 Reads

Fetal Anthropometric Features: A Postmortem Study of Fetuses After the Termination of Pregnancy for Psychosocial Reasons Between 12 and 20 Gestational Weeks.

Pediatr Dev Pathol 2018 Nov 19:1093526618812528. Epub 2018 Nov 19.

3 Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.

Introduction: Reference ranges in fetal postmortem anthropometric data derive from heterogeneous studies and rely on data obtained after intrauterine fetal death and abortion, which may introduce bias in the reported fetal growth parameters. We report anthropometric findings in fetuses with the least variation due to cause of death or developmental anomalies.

Methods: We analyzed fetuses after the termination of pregnancy for psychosocial reasons. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618812528
Publisher Site
http://dx.doi.org/10.1177/1093526618812528DOI Listing
November 2018
6 Reads

Adequacy and Accuracy of Core Biopsy in Children: A Radiologic/Pathologic Correlation Study.

Pediatr Dev Pathol 2018 Nov 14:1093526618809862. Epub 2018 Nov 14.

1 Department of Pathology, Children's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, Wisconsin.

Core biopsy (CB) is increasingly popular for assessing solid lesions in children. To date, pediatric literature is limited regarding factors contributing to diagnostically inadequate or inaccurate CB. Therefore, we retrospectively examined radiologic/pathologic factors associated with adequacy/accuracy of CB in pediatric patients. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618809862
Publisher Site
http://dx.doi.org/10.1177/1093526618809862DOI Listing
November 2018
9 Reads

Genetic Analysis of Copy Number Variation in Large Chorangiomas.

Pediatr Dev Pathol 2018 Nov 14:1093526618811744. Epub 2018 Nov 14.

1 Section of Perinatal Pathology, Department of Pathology, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Introduction: Chorangioma (CA) is the most common nontrophoblastic, vascular tumor-like lesion of the placenta with a reported incidence of 0.5% to 1% in all examined placentas. The underlying molecular mechanisms of CAs are still poorly elucidated, and a systematic investigation of the genetic background of CAs has not previously been done. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618811744DOI Listing
November 2018
22 Reads

Pediatric Anastomosing Hemangioma: Case Report and Review of Renal Vascular Tumors in Children.

Pediatr Dev Pathol 2018 Oct 28:1093526618809230. Epub 2018 Oct 28.

5 Department of Pathology and Laboratory Medicine, National Kidney and Transplant Institute, Philippines.

The case involves a 10-year-old child who underwent a left radical nephrectomy for what was believed to be a Wilms' tumor. Histopath examination indicated a benign vascular lesion, subsequently determined to be an anastomosing hemangioma of the kidney. A comparison with the previously cited pediatric patients with renal vascular tumors is provided, and the inconsistent diagnostic terminologies for these conditions are highlighted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618809230DOI Listing
October 2018
8 Reads

Spectrum of Changes Seen With Placental Intravascular Organisms.

Pediatr Dev Pathol 2018 Oct 18:1093526618801616. Epub 2018 Oct 18.

4 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Fetal bacterial infections are a common cause of fetal/neonatal morbidity and mortality. The pathologic correlates of congenital bacterial infection include acute chorioamnionitis, acute villitis, and acute intervillositis. The strength of the association of congenital bacterial infection differs among these pathologies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618801616DOI Listing
October 2018
12 Reads

Primary Nonanaplastic Peripheral Natural Killer/T-Cell Lymphoma in Pediatric Patients-An Unusual Distribution Pattern of Subtypes.

Pediatr Dev Pathol 2018 Oct 18:1093526618807110. Epub 2018 Oct 18.

1 Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado.

Peripheral NK/T-cell lymphoma (PNKTCL) represents a group of uncommon diagnoses for children in Western countries, and studies have often necessitated multiple institutions to assemble enough cases. We retrospectively analyzed 11 cases of nonanaplastic PNKTCL in children over 19 years at our institution with comparison to several published large multi-institutional studies. Patients included 9 males and 2 females of white (5), Native American (3), and Hispanic (3) background with 6 cases of extranodal NK/T-cell lymphoma, nasal type (EN-NKTL, 54. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618807110DOI Listing
October 2018
1 Read

Paraspinal Leiomyoma.

Pediatr Dev Pathol 2018 Oct 17:1093526618808723. Epub 2018 Oct 17.

1 Department of Pathology, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618808723
Publisher Site
http://dx.doi.org/10.1177/1093526618808723DOI Listing
October 2018
3 Reads

Myxoid Lipoblastoma and Mimickers on Fine-Needle Biopsy in a Child.

Pediatr Dev Pathol 2018 Oct 15:1093526618805894. Epub 2018 Oct 15.

1 Service d'Anatomie et de Cytologie Pathologiques, Hôpital d'Enfants Armand Trousseau, Université Pierre et Marie Curie, Paris, France.

Image-guided percutaneous core needle biopsy is a standard and safe procedure for the diagnosis of both solid and hematological malignancies in children. Despite recent improvements, nondiagnosis biopsies persist. Lipoblastoma is a benign adipocytic tumor composed of embryonal fat admixed with mature adipocytes and occurring before the age of 1 year in one-third of cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618805894DOI Listing
October 2018
13 Reads

Variation in Platelet Delta Granules Over Time in Young Women Undergoing Evaluation for Heavy Menstrual Bleeding.

Pediatr Dev Pathol 2018 Oct 9:1093526618803838. Epub 2018 Oct 9.

3 Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital, Columbus, Ohio.

Delta-granule platelet storage pool deficiency (δ-PSPD) is a qualitative platelet function defect associated with variable bleeding phenotypes. Platelet electron microscopy (EM) is commonly utilized to evaluate for δ-PSPD, but intrapatient variability in platelet δ-granule numbers by EM is currently unknown. Fifteen young women aged 11 to 17 years presenting to a young women's hematology clinic for the evaluation of heavy menstrual bleeding underwent platelet EM testing at their initial hematology clinic visit and at 1 and 3 months later. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618803838
Publisher Site
http://dx.doi.org/10.1177/1093526618803838DOI Listing
October 2018
15 Reads

Correlation of Endoscopic and Histologic Severity Scores in Pediatric Ulcerative Colitis at First Presentation.

Pediatr Dev Pathol 2018 Oct 9:1093526618803736. Epub 2018 Oct 9.

1 Division of Pediatric Pathology, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Detailed histologic scoring systems have been developed for the assessment of disease activity in ulcerative colitis. Literature from adult patients has shown some correlation between endoscopy and histology, and reproducibility of histologic scoring systems has also been supported. The effectiveness of endoscopic appearance at predicting histologic scores in pediatric patients has not been well studied, and none of the histologic scoring systems used in adults have had interobserver reproducibility assessed in pediatric patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618803736DOI Listing
October 2018
9 Reads

Histological Features of Shallow Placental Implantation Unify Early-Onset and Late-Onset Preeclampsia.

Authors:
Jerzy Stanek

Pediatr Dev Pathol 2018 Oct 9:1093526618803759. Epub 2018 Oct 9.

1 Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Preeclampsia is distinguishable from other hypertensive conditions of pregnancy by its high rates of decidual arteriopathy, the uterine type of chronic hypoxic placental injury, the occurrence of villous infarctions, and clusters of multinucleate trophoblasts in the maternal floor. To retrospectively study the clinical and placental phenotypes of 230 women with early-onset preeclampsia, 261 women with late-onset preeclampsia, and 5059 women without hypertension in pregnancy (comparative group), 24 clinical and 46 placental phenotypes were statistically compared (analysis of variance, χ with Bonferroni correction). The frequency of decidual arteriopathy (both hypertrophic and atherosis), patterns of chronic hypoxic placental injury, villous infarction, membrane laminar necrosis, membrane microscopic chorionic pseudocysts, clusters of maternal floor multinucleated trophoblasts, excessive number of extravillous trophoblasts, and intervillous thrombi was strikingly higher in both late-onset preeclampsia and early-onset preeclampsia than in the comparative group without hypertension in pregnancy. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618803759
Publisher Site
http://dx.doi.org/10.1177/1093526618803759DOI Listing
October 2018
3 Reads

Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor With SDHC Germline Mutation and Bilateral Renal and Neck Cysts.

Pediatr Dev Pathol 2018 Oct 9:1093526618805354. Epub 2018 Oct 9.

2 Department of Pathology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

Gastrointestinal stromal tumors (GISTs) are rare in children. Succinate dehydrogenase (SDH)-deficient GISTs are wild type and lack KIT proto-oncogene receptor tyrosine kinase and platelet-derived growth factor receptor A ( KIT or PDGFRA) mutations. These tumors result from germline SDH mutations, somatic SDH mutations, or SDH epimutants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618805354DOI Listing
October 2018
16 Reads

Early Onset Allergic Proctitis in a Preterm Neonate-A Case Report and Review of the Literature.

Pediatr Dev Pathol 2018 Oct 4:1093526618803770. Epub 2018 Oct 4.

3 Department of Pediatrics, Division of gastroenterology, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.

Cow's milk protein allergy/intolerance (CMPA/CMPI) is a common entity in the pediatric population with a nonspecific presentation ranging from gastrointestinal symptoms to systemic manifestations. Most infants with CMPI are term, and symptoms often appear in the week following the introduction of cow's milk-based formula. There is typically a significant delay in the onset of milk allergy in premature infants compared to full term. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618803770
Publisher Site
http://dx.doi.org/10.1177/1093526618803770DOI Listing
October 2018
2 Reads
0.860 Impact Factor

Placental Histology After Minor Trauma in Pregnancy: A Pilot Study.

Pediatr Dev Pathol 2018 Sep 12:1093526618799292. Epub 2018 Sep 12.

1 Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, the Netherlands.

Objective Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618799292DOI Listing
September 2018
12 Reads

Postmortem Diagnosis of Heart-hand Syndrome Associated With a 7p22.1p22.3 Deletion in a 16-week-old Fetus.

Pediatr Dev Pathol 2018 Sep 7:1093526618799293. Epub 2018 Sep 7.

2 Service d'anatomopathologie, CHU Charles Nicolle, Rouen, France.

We report a male fetus with a 6.8 Mb deletion on chromosome 7p22.1p22. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618799293
Publisher Site
http://dx.doi.org/10.1177/1093526618799293DOI Listing
September 2018
6 Reads

Pathology of Neonatal Non- albicans Candidiasis: Autopsy Study and Literature Review.

Pediatr Dev Pathol 2018 Sep 7:1093526618798773. Epub 2018 Sep 7.

1 Department of Pathology, Women and Infants Hospital, Providence, Rhode Island.

Introduction/Objectives Non- albicans Candida species such as Candida parapsilosis and Candida glabrata have emerged as prevalent pathogens in premature infants. The aim of this study was to systematically delineate the histopathologic findings in neonatal non- albicans candidiasis. Methods We performed a retrospective clinicopathologic analysis of extremely premature (23-28 weeks' gestation) infants diagnosed with invasive candidiasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618798773DOI Listing
September 2018
10 Reads

Massive Perivillous Fibrin Deposition of an Enterovirus A-Infected Placenta Associated With Stillbirth: A Case Report.

Pediatr Dev Pathol 2018 Sep 7:1093526618798772. Epub 2018 Sep 7.

5 Department of Virology, Hannover Medical School, Hannover, Germany.

Massive perivillous fibrin deposition (MFD) is a morphologically defined severe placental lesion associated with perinatal morbidity and mortality. The etiology is unknown, and recurrence risk in subsequent pregnancies is assumed to be high. In most cases, a pathologic immune reaction is supposed to be responsible for the lesion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618798772DOI Listing
September 2018
3 Reads

Clinicopathologic Features and Chromosome 12p Status of Pediatric Sacrococcygeal Teratomas: A Multi-institutional Analysis.

Pediatr Dev Pathol 2018 Sep 3:1093526618798771. Epub 2018 Sep 3.

3 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

Chromosome 12p gains are typically present in postpubertal male patients with testicular malignant germ cell tumors, including most teratomas, and absent in pure ovarian teratomas, both mature and immature. We sought to evaluate the clinicopathologic features and chromosome 12p status of pediatric patients with sacrococcygeal teratomas (SCTs) using the institutional databases of 2 tertiary medical centers. Seven mature teratomas (3 pure, 2 with yolk sac tumor, 1 with medulloepithelioma, and 1 with ependymoma) and 3 immature teratomas (2 pure: grade 2 and grade 3 and 1 mixed: grade 3 with yolk sac tumor) were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618798771DOI Listing
September 2018
6 Reads

Putative Cellular and Molecular Roles of Zika Virus in Fetal and Pediatric Neuropathologies.

Pediatr Dev Pathol 2018 Aug 27:1093526618790742. Epub 2018 Aug 27.

1 Department of Biological Sciences, Bronx Community College, The City University of New York, Bronx, New York.

Although the World Health Organization declared an end to the recent Zika virus (ZIKV) outbreak and its association with adverse fetal and pediatric outcome, on November 18, 2016, the virus still remains a severe public health threat. Laboratory experiments thus far supported the suspicions that ZIKV is a teratogenic agent. Evidence indicated that ZIKV infection cripples the host cells' innate immune responses, allowing productive replication and potential dissemination of the virus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618790742DOI Listing
August 2018
1 Read

Pioneer in Pediatric Pathology: William A (Bill) Newton Jr (1923-).

Pediatr Dev Pathol 2018 Aug 20:1093526618794831. Epub 2018 Aug 20.

4 Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California.

William A (Bill) Newton Jr practiced pediatric pathology and hematology/oncology at Children's Hospital of Columbus, Ohio, for over 40 years starting in 1952. Newton was an original member of the Pediatric Pathology Club, which preceded the Society for Pediatric Pathology, and was its president from 1968 to 1969. He published important independent observations in pediatric pathology, helped establish systematic cooperative pediatric tumor pathology review by experts, became an acclaimed expert on the diagnosis of rhabdomyosarcoma, was a critical contributor to many pediatric oncology clinical trials, made important early contributions to tumor banking in pediatrics, and trained numerous pediatric pathology and pediatric oncology fellows. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618794831DOI Listing
August 2018
2 Reads

Infantile Myofibromatosis With Intracranial Extradural Involvement and PDGFRB Mutation: A Case Report and Review of the Literature.

Pediatr Dev Pathol 2018 Aug 13:1093526618787736. Epub 2018 Aug 13.

1 Department of Pathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

Infantile myofibroma is a rare benign mesenchymal tumor that presents as solitary or multiple lesions (myofibromatosis) in the skin, soft tissue, bone, or internal organs. It most commonly affects the head and neck of infants and young children, but it can also affect adults. Intracranial involvement is reported to be extremely rare, and its clinical picture has been poorly characterized. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1093526618787736
Publisher Site
http://dx.doi.org/10.1177/1093526618787736DOI Listing
August 2018
26 Reads

Sarcoma Subgrouping by Detection of Fusion Transcripts Using NanoString nCounter Technology.

Pediatr Dev Pathol 2018 Aug 8:1093526618790747. Epub 2018 Aug 8.

1 Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

Background NanoString technology is an innovative barcode-based system that requires less tissue than traditional techniques and can test for multiple fusion transcripts in a single reaction. The objective of this study was to determine the utility of NanoString technology in the detection of sarcoma-specific fusion transcripts in pediatric sarcomas. Design Probe pairs for the most common pediatric sarcoma fusion transcripts were designed for the assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618790747DOI Listing
August 2018
5 Reads

Travel History Is Important! A Case of Trypanosoma cruzi Identified by Placental Examination.

Pediatr Dev Pathol 2018 07 16:1093526618789298. Epub 2018 Jul 16.

5 Department of Pathology, University of Alabama, Birmingham, Alabama.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618789298DOI Listing
July 2018
1 Read

Associations Between the Features of Gross Placental Morphology and Birthweight.

Pediatr Dev Pathol 2018 07 16:1093526618789310. Epub 2018 Jul 16.

1 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

The placenta plays a critical role in regulating fetal growth. Recent studies suggest that there may be sex-specific differences in placental development. The purpose of our study was to evaluate the associations between birthweight and placental morphology in models adjusted for covariates and to assess sex-specific differences in these associations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618789310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335186PMC
July 2018
3 Reads

Histopathology of Unilateral Cryptorchidism.

Pediatr Dev Pathol 2018 07 16:1093526618789300. Epub 2018 Jul 16.

4 Cryptorchidism Research Institute, Kindermedizinisches Zentrum Liestal, Liestal, Switzerland.

Defective mini-puberty inducing insufficient gonadotropin secretion is one of the most common causes of nonobstructive azoospermia in men suffering from congenital isolated unilateral or bilateral cryptorchidism. The aim of our study was to determine the risk for azoospermia by histologic criteria in a cohort of unilateral cryptorchid boys undergoing orchidopexy and bilateral testicular biopsy. We performed a retrospective analysis of data available in the library of the Cryptorchidism Research Institute, Liestal, Switzerland. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618789300DOI Listing
July 2018
5 Reads

Association of Maternal Prepregnancy Body Mass Index With Placental Histopathological Characteristics in Uncomplicated Term Pregnancies.

Pediatr Dev Pathol 2018 07 3:1093526618785838. Epub 2018 Jul 3.

4 Department of Pathology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Introduction Prepregnancy obesity is a growing global health problem and has several risks for mother and child. The aim of this study was to systematically examine the effect of increased maternal body mass index (BMI) on placental pathology in otherwise uneventful term pregnancies. Methods In this analysis, we studied data of the Netherlands Amniotic Fluid study, a prospective study of women delivering in Utrecht, the Netherlands, between 2006 and 2007. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618785838DOI Listing
July 2018
10 Reads

Myocardial Infarct After Marijuana Inhalation in a 16-year-old Adolescent Boy.

Pediatr Dev Pathol 2018 06 29:1093526618785552. Epub 2018 Jun 29.

1 Harvard Medical Toxicology Program, Boston Children's Hospital, Boston, Massachusetts.

Many reports of marijuana-associated myocardial infarct (MI) are limited by incomplete evaluation of the toxicologic exposure, a lack of definitive anatomic findings, and the potential for comorbid coronary atherosclerosis inherent in an adult population. We report a 16-year-old adolescent boy who presented with chest pain after smoking marijuana and was found to have acute MI. Electrocardiogram showed diffuse ST-segment elevations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618785552DOI Listing
June 2018
5 Reads

Abstracts from the meeting of the Paediatric Pathology Society, Lisbon, September 7-9th 2017.

Authors:

Pediatr Dev Pathol 2018 06 20:1093526618777181. Epub 2018 Jun 20.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618777181DOI Listing

Discordance of Twin Placentas for Multifocal Eosinophilic/T-cell Chorionic Vasculitis.

Pediatr Dev Pathol 2018 06 18:1093526618783256. Epub 2018 Jun 18.

1 Department of Pathology & Laboratory Medicine, University of Calgary/Calgary Laboratory Services, Alberta Children's Hospital, Calgary, Alberta, Canada.

Eosinophilic/T-cell chorionic vasculitis (ETCV) is an idiopathic placental lesion characterized by chorionic vasculitis composed predominantly of eosinophils and CD3+ T lymphocytes. It usually presents as a unifocal lesion, but a subset have multifocal involvement. We report 4 Di-Di and 2 Di-Mo twins sharing fused placental discs with discordant circulatory involvement by multifocal ETCV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1093526618783256DOI Listing
June 2018
1 Read