3,363 results match your criteria Pediatric Transplantation[Journal]


Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases.

Pediatr Transplant 2019 Feb 21:e13379. Epub 2019 Feb 21.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Database linkage is a common strategy to expand analytic possibilities. Our group recently completed a linkage between the SRTR and PHIS databases for pediatric heart transplant recipients. The aim of this project was to expand the linkage between SRTR and PHIS to include liver, kidney, lung, heart-lung, and small bowel transplants. Read More

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February 2019

Post-transplant metabolic syndrome in children: Know better to cure better.

Pediatr Transplant 2019 Feb 21:e13367. Epub 2019 Feb 21.

Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Gesù Children's Research Hospital IRCCS, Rome, Italy.

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February 2019

Successful hematopoietic stem cell transplantation from an HLA-mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases.

Pediatr Transplant 2019 Feb 20:e13378. Epub 2019 Feb 20.

Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

JMML is an aggressive hematopoietic malignancy of early childhood, and allogeneic HSCT is the only curative treatment for this disease. Umbilical cord blood is one of donor sources for HSCT in JMML patients who do not have an HLA-compatible relative, but engraftment failure remains a major problem. Here, we report two cases of JMML who were successfully rescued by HSCT from an HLA-mismatched parent after development of primary engraftment failure following unrelated CBT. Read More

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February 2019

Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis.

Pediatr Transplant 2019 Feb 20:e13382. Epub 2019 Feb 20.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Background: CMV is associated with adverse effects in renal transplant recipients. The objective of this study was to characterize the incidence and timing of CMV and EBV infections in relation to valGCV prophylaxis in a pediatric renal transplant cohort.

Methods: Retrospective cohort of pediatric renal transplant patients given universal valGCV prophylaxis and universal viral surveillance was evaluated. Read More

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February 2019

Psychotropic medication use trends in a large pediatric and young adult solid organ transplant population.

Pediatr Transplant 2019 Feb 20:e13380. Epub 2019 Feb 20.

Boston Children's Hospital Department of Psychiatry, Boston, Massachusetts.

Introduction: This study describes psychotropic medication use in a pediatric and young adult solid organ transplant population.

Methods: We conducted a retrospective review of the lifetime incidence of psychotropic medication use and associated characteristics in patients seen over a 6-year period at a large pediatric transplant center utilizing univariate and multivariate statistical analyses.

Results: The lifetime incidence of psychotropic medication use was 36. Read More

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http://dx.doi.org/10.1111/petr.13380DOI Listing
February 2019

Hematopoietic stem cell transplantation in children with sickle cell anemia: The parents' experience.

Pediatr Transplant 2019 Feb 20:e13376. Epub 2019 Feb 20.

Department of Psychopathology, Avicenne Hospital, Paris XIII University & Assistance Publique-Hôpitaux de Paris, Bobigny, France.

Genoidentical HSCT is currently the only curative treatment for SCA, preventing further vascular complications in high-risk children. Studies on the psychological implications of HSCT for recipient, sibling donor, and the rest of the family have been limited in SCA. This study enrolled ten families and used semi-structured interviews to explore the parents' experience at three time points: first before transplantation, then 3 months later, and 1 year later. Read More

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http://dx.doi.org/10.1111/petr.13376DOI Listing
February 2019

Gastrostomy tubes appear to be safe following pediatric orthotopic heart transplant.

Pediatr Transplant 2019 Feb 20:e13374. Epub 2019 Feb 20.

Division of Pediatric Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.

Background: Gastrostomy tube (GT) placement is a common pediatric surgical procedure typically indicated for oral aversion. This may develop in patients with congenital heart disease (CHD) who require an orthotopic heart transplant (OHT). The safety profile of GT placement in OHT patients who are immunosuppressed is unknown. Read More

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http://doi.wiley.com/10.1111/petr.13374
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February 2019
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Sequential transplantation and implications for clinical management: OLT followed by HCT and consequent RT in a pediatric patient.

Pediatr Transplant 2019 Feb 18:e13370. Epub 2019 Feb 18.

Section of Hematology, Oncology and BMT, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

We report a case of a pediatric patient who required three separate transplants: OLT at the age 5, HCT at age 13 (8 years post-OLT), and cadaveric RT at age 15 (10 years post-OLT). The child initially presented with fulminant liver failure without known cause, ultimately undergoing OLT from his mother. He then developed SAA, for which he required HCT. Read More

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February 2019

Single kidney transplantation from donors with acute kidney injury: A single-center experience.

Pediatr Transplant 2019 Feb 15:e13326. Epub 2019 Feb 15.

Department of Urology, West China Hospital, Sichuan University, Chengdu, China.

Introduction: Despite a severe shortage of organ supply, patients are reluctant to accept organs from deceased donors with AKI, let alone from pediatric AKI donors.

Methods: We assessed 70 patients who received kidneys from donors with AKI (10 with pediatric and 60 with adult donors) and 176 contemporaneous patients who received kidneys from non-AKI donors (41 with pediatric and 135 with adult donors) between March 2012 and February 2017 for retrospectively evaluating the clinical outcomes.

Results: AKI was defined and staging by the RIFLE criteria and pediatric-modified RIFLE criteria. Read More

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http://dx.doi.org/10.1111/petr.13326DOI Listing
February 2019
3 Reads

The T-helper cells 17 instead of Tregs play the key role in acute rejection after pediatric liver transplantation.

Pediatr Transplant 2019 Feb 12:e13363. Epub 2019 Feb 12.

Department of Transplant Surgery, Tianjin First Center Hospital, Tianjin, China.

Th17 and imbalance of Treg/Th17 might be one of the mechanisms of acute rejection. We aim to explore the role of Th17s in the balance of Treg/Th17 in acute rejection after LT in children diagnosed with BA. The ratios of Treg and Th17 in peripheral blood were detected by flow cytometry pre-LT, post-LT, and when rejection occurred. Read More

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http://doi.wiley.com/10.1111/petr.13363
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http://dx.doi.org/10.1111/petr.13363DOI Listing
February 2019
2 Reads

Comparison of 10-year graft failure rates after induction with basiliximab or anti-thymocyte globulin in pediatric heart transplant recipients-The influence of race.

Pediatr Transplant 2019 Feb 8:e13366. Epub 2019 Feb 8.

Division of Pediatric Cardiothoracic Surgery, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background/objective: The impact of induction therapy in pediatric heart transplantation has been uncertain. Given the risk of poor outcomes in black pediatric heart transplant recipients, we evaluated the effect on graft survival of ATG and BAS induction in black and non-black pediatric recipients.

Methods: This was a retrospective analysis of pediatric candidates (aged ≤18 years) who underwent heart transplantation from 2000 to 2016 identified from the UNOS database. Read More

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http://dx.doi.org/10.1111/petr.13366DOI Listing
February 2019
1 Read

A comparison of post-transplant renal function in pre-emptive and post-dialysis pediatric kidney transplant recipients.

Pediatr Transplant 2019 Feb 8:e13377. Epub 2019 Feb 8.

Division of Urology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: Little is known regarding post-transplant renal function following pediatric pre-emptive KT. Therefore, this study aims to determine whether there is a difference in 1 year post-transplant renal function outcomes between pre-emptive and post-dialysis KT in pediatric transplant recipients.

Methods: A retrospective review of patients who underwent kidney transplant at our institution between 2000 and 2015 was performed. Read More

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February 2019
1 Read

Communication about prognosis and end-of-life in pediatric organ failure and transplantation.

Pediatr Transplant 2019 Feb 7:e13373. Epub 2019 Feb 7.

Department of Pediatrics, Michigan Medicine, Ann Arbor, Michigan.

Background: Despite advancements in treatment and survival, pediatric organ failure and transplant populations continue to face significant risks of morbidity and mortality. Little scientific attention has been given to addressing the end-of-life care needs of this growing population of young people. This study characterized current practices, beliefs, and challenges specific to the disclosure of prognosis and end-of-life care topics among providers caring for pediatric organ failure and transplant populations. Read More

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http://dx.doi.org/10.1111/petr.13373DOI Listing
February 2019

"Inverted" positioning of renal allograft during kidney transplantation in children and adolescents: A single-institution comparative analysis.

Pediatr Transplant 2019 Feb 7:e13365. Epub 2019 Feb 7.

Department of Urology, Hospital for Sick Children, Toronto, Ontario, Canada.

Renal transplantation is the treatment of choice in children with end-stage renal failure. Limitations in patient anatomy or a short donor renal vein may necessitate intraoperative inversion of the kidney. There is little evidence to support the use of this surgical technique, and no evidence in the pediatric population. Read More

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February 2019

Compassionate deactivation of ventricular assist devices in children: A survey of pediatric ventricular assist device clinicians' perspectives and practices.

Pediatr Transplant 2019 Feb 7:e13359. Epub 2019 Feb 7.

Department of Cardiology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts.

Objectives: This study's objective was to investigate compassionate ventricular assist device deactivation (VADdeact) in children from the perspective of the pediatric heart failure provider.

Background: Pediatric VAD use is a standard therapy for advanced heart failure. Serious adverse events may affect relative benefit of continued support, leading to consideration of VADdeact. Read More

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http://dx.doi.org/10.1111/petr.13359DOI Listing
February 2019

Development of a multinational registry of pediatric deceased organ donation activity.

Pediatr Transplant 2019 Feb 5:e13345. Epub 2019 Feb 5.

Deceased Donation, Canadian Blood Services, Ottawa, Ontario, Canada.

Background: There are no currently agreed upon international standards for reporting of pediatric deceased organ donation activity. This leads to difficulty in comparisons between jurisdictions for both researchers and policy stakeholders. The goal of this project was to develop and test a standardized registry for pediatric deceased donation activity. Read More

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http://dx.doi.org/10.1111/petr.13345DOI Listing
February 2019

Early post-operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus.

Pediatr Transplant 2019 Feb 4:e13368. Epub 2019 Feb 4.

Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

We aimed to compare the early results of i.v. with p. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13368
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February 2019
4 Reads

Indications and efficacy of conversion from tacrolimus- to sirolimus-based immunosuppression in pediatric patients who underwent liver transplantation for unresectable hepatoblastoma.

Pediatr Transplant 2019 Feb 4:e13369. Epub 2019 Feb 4.

Department of Surgery, Children's Mercy Hospital, Kansas City, Missouri.

SRL-based immunosuppressive strategies in pediatric liver transplantation are not clearly defined, especially within the first year after liver transplant. TAC is the more common, traditional immunosuppressant used. However, SRL may modulate TAC-associated kidney injury and may also have antiproliferative properties that are valuable in the management of patients following liver transplantation for HB. Read More

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http://dx.doi.org/10.1111/petr.13369DOI Listing
February 2019

Non-invasive differentiation of non-rejection kidney injury from acute rejection in pediatric renal transplant recipients.

Pediatr Transplant 2019 Feb 4:e13364. Epub 2019 Feb 4.

Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

Acute kidney injury (AKI) is a major concern in pediatric kidney transplant recipients, where non-alloimmune causes must be distinguished from rejection. We sought to identify a urinary metabolite signature associated with non-rejection kidney injury (NRKI) in pediatric kidney transplant recipients. Urine samples (n = 396) from 60 pediatric transplant participants were obtained at time of kidney biopsy and quantitatively assayed for 133 metabolites by mass spectrometry. Read More

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http://dx.doi.org/10.1111/petr.13364DOI Listing
February 2019
4 Reads

Ovarian function after allogeneic hematopoietic stem cell transplantation in children and young adults given 8-Gy total body irradiation-based reduced-toxicity myeloablative conditioning.

Pediatr Transplant 2019 Feb 3:e13372. Epub 2019 Feb 3.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Background: The spectrum of late sequelae after hematopoietic stem cell transplantation (HSCT) includes infertility, which is the most frequent complication. Some reports suggested that ovarian function may be better preserved in females undergoing HSCT with reduced-intensity conditioning (RIC) than with conventional myeloablative conditioning (MAC). However, the impact of HSCT after 8-Gy TBI-based reduced-toxicity MAC (RTMAC), whose efficacy is between those of conventional MAC and RIC, on ovarian function remains unclear. Read More

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http://dx.doi.org/10.1111/petr.13372DOI Listing
February 2019
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De novo leukocyte chemotactic factor 2 amyloidosis in a pediatric renal allograft, 15 years post-transplant.

Pediatr Transplant 2019 Feb 3:e13371. Epub 2019 Feb 3.

Department of Pathology, University of California San Francisco, San Francisco, California.

Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a recently described form of systemic amyloidosis, which most commonly affects the kidney and liver. The LECT2 protein is produced during inflammatory processes, but its precise function in renal diseases in unclear. ALECT2, however, is known to be a relatively common form of renal amyloidosis, after amyloid light chain and serum amyloid A types and is most often seen in patients of Hispanic ethnicity. Read More

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http://dx.doi.org/10.1111/petr.13371DOI Listing
February 2019

Effects of the influenza vaccine on pediatric kidney transplant outcomes.

Pediatr Transplant 2019 Mar 3;23(2):e13354. Epub 2019 Feb 3.

Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

The influenza vaccine is critical for preventing influenza-related complications in transplant patients. Previous studies demonstrated de novo donor-specific antibody formation and rejection following the influenza vaccination. This risk has not been adequately assessed in the pediatric population. Read More

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http://dx.doi.org/10.1111/petr.13354DOI Listing

Prediction of mortality following pediatric heart transplant using machine learning algorithms.

Pediatr Transplant 2019 Jan 29:e13360. Epub 2019 Jan 29.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio.

Background: Optimizing transplant candidates' priority for donor organs depends on the accurate assessment of post-transplant outcomes. Due to the complexity of transplantation and the wide range of possible serious complications, recipient outcomes are difficult to predict accurately using conventional multivariable regression. Therefore, we evaluated the utility of 3 ML algorithms for predicting mortality after pediatric HTx. Read More

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http://dx.doi.org/10.1111/petr.13360DOI Listing
January 2019

RELATE: Relationship of limited sampling strategy and adverse effects of mycophenolate mofetil in pediatric renal transplant patients.

Pediatr Transplant 2019 Mar 28;23(2):e13355. Epub 2019 Jan 28.

Lower Mainland Pharmacy Services, Children's & Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada.

MMF, a prodrug converted to the active form MPA, is an immunosuppressant used to prevent rejection in solid organ transplant recipients. MPA exposure, defined by AUC, can be estimated using limited sampling strategies (LSS). The relationship between MPA AUC and clinical outcomes has not been studied in pediatrics. Read More

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http://dx.doi.org/10.1111/petr.13355DOI Listing

Oral ribavirin for paramyxovirus infection after alemtuzumab-containing reduced-intensity conditioning HCT regimen.

Pediatr Transplant 2019 Mar 27;23(2):e13358. Epub 2019 Jan 27.

Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.

Aerosolized ribavirin has been used in pediatric immunocompromised patients to treat acute respiratory viral infections, but oral ribavirin may be a less expensive alternative that allows for outpatient therapy. Oral ribavirin has compared favorably to aerosolized ribavirin in adult studies, but data on safety are lacking in pediatric populations. Four cases are described in which oral ribavirin was used to treat viral respiratory infections in recipients of allogeneic hematopoietic stem cell transplants at a Children's Hospital, demonstrating safety and feasibility. Read More

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Pediatric living donor liver transplant in a recipient with biliary atresia and portal vein duplication-How did we manage it?

Pediatr Transplant 2019 Mar 24;23(2):e13356. Epub 2019 Jan 24.

Unidad de Trasplante Hepático, Hospital Universitario Fundación Favaloro, Buenos Aires, Argentina.

Portal vein malformations might occur during the embryonic period, as a consequence of abnormal remodeling of vitelline veins during embryonic life. Patients suffering from biliary atresia are particularly prone to have vascular malformations; although being the most frequent indication for liver transplantation in the pediatric age, portal vein duplication has not been so far associated with biliary atresia, and to the best of our knowledge, there is no-written evidence describing how to manage it when it is first diagnosed while performing a pediatric liver transplant. Therefore, we present a recent case from our group, describing the intraoperative diagnosis of a double portal system in a patient with biliary atresia and failed Kasai. Read More

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http://dx.doi.org/10.1111/petr.13356DOI Listing
March 2019
2 Reads

Donor mucosal immunocytes perpetuate refractory GVHD after intestinal transplantation without engrafting in recipient bone marrow: Case report and review of the literature.

Pediatr Transplant 2019 Mar 22;23(2):e13350. Epub 2019 Jan 22.

Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

GVHD as a complication of SOT presents both a diagnostic and therapeutic challenge. Typically affecting the skin, gastrointestinal tract, and liver, GVHD occurs when donor lymphocytes engrafted in recipient tissues are activated by host antigen-presenting cells resulting in cytokine release and donor cell-mediated cytotoxicity to host tissue. Here, we describe a 5-year-old girl who developed fatal, refractory GVHD after isolated intestinal transplantation when recipient immune cells failed to repopulate the allograft in the setting of CMV viremia. Read More

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http://dx.doi.org/10.1111/petr.13350DOI Listing
March 2019
3 Reads

Pharmacokinetics of tacrolimus granules in pediatric de novo liver, kidney, and heart transplantation: The OPTION study.

Pediatr Transplant 2019 02 21;23(1):e13328. Epub 2019 Jan 21.

Astellas Pharma EMEA, Chertsey, Surrey, UK.

Tacrolimus granules were developed for patients who are unable to swallow capsules. Therapeutic drug monitoring (TDM) is required to optimize efficacy and safety, which is based on C for tacrolimus capsules. Pharmacokinetic (PK) data for tacrolimus granules are required to establish the basis for TDM in those who are unable to swallow capsules. Read More

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http://dx.doi.org/10.1111/petr.13328DOI Listing
February 2019
3 Reads

Center variation in screening for and management of metabolic syndrome in pediatric liver transplant recipients: A survey of SPLIT centers.

Pediatr Transplant 2019 Jan 21:e13347. Epub 2019 Jan 21.

Department of Pediatrics, UCSF, San Francisco, California.

Introduction: PTMS-a clustering of hypertension, dyslipidemia, glucose intolerance/diabetes, and obesity-is increasingly recognized as a contributor to long-term morbidity after transplant. We sought to describe pediatric liver transplant center protocols and provider practices in screening for and managing these conditions.

Methods: Cross-sectional survey of pediatric liver transplant providers from centers that participate in Studies of Liver Transplantation (SPLIT). Read More

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http://dx.doi.org/10.1111/petr.13347DOI Listing
January 2019
3 Reads

Purtscher-like retinopathy: A rare presentation of hematopoietic stem cell transplant-associated thrombotic microangiopathy.

Pediatr Transplant 2019 Mar 20;23(2):e13344. Epub 2019 Jan 20.

Division of Pediatric Hematology Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas.

Hematopoietic stem cell transplant (HSCT)-associated (TA) thrombotic microangiopathy (TMA) is an acquired disorder and a potentially life-threatening complication after allogeneic HSCT. TA-TMA causes endothelial damage and results in micro-thrombi in capillaries and arterioles. Early detection and treatment of complications associated with TA-TMA might improve outcomes. Read More

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http://dx.doi.org/10.1111/petr.13344DOI Listing
March 2019
2 Reads

Various initial presentations of Epstein-Barr virus infection-associated post-transplant lymphoproliferative disorder in pediatric liver transplantation recipients: Case series and literature review.

Pediatr Transplant 2019 Mar 20;23(2):e13357. Epub 2019 Jan 20.

Faculty of Medicine Ramathibodi Hospital, Department of Pediatrics, Division of Gastroenterology, Mahidol University, Bangkok, Thailand.

PTLD is a rare but potentially life-threatening condition, which shows a higher prevalence in children than in adults. From 129 children who underwent LT, we reported 5 cases with biopsy-proven PTLD at a single teaching hospital. Four patients had shared clinical presentations including fever, lymphadenopathy, and splenomegaly. Read More

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http://doi.wiley.com/10.1111/petr.13357
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March 2019
6 Reads

Medication adherence in pediatric renal transplant patients: The role of family functioning and parent health locus of control.

Pediatr Transplant 2019 Mar 20;23(2):e13346. Epub 2019 Jan 20.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Children and adolescents with renal disease experience daily social, emotional, and medical challenges. Renal transplantation can help to improve quality of life but requires a lifelong regimen of immunosuppressant medication to maintain health. Adherence to a daily complex regimen can be difficult, particularly for adolescents who are beginning to develop autonomy from caregivers and are faced with a unique set of socio-emotional challenges. Read More

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http://doi.wiley.com/10.1111/petr.13346
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March 2019
5 Reads

Evaluation of the current post-transplantation Human Leukocyte Antigen antibody screening in pediatric renal transplant recipients.

Pediatr Transplant 2019 Mar 11;23(2):e13338. Epub 2019 Jan 11.

Pediatric Nephrology Department, Emma Children's Hospital, Amsterdam UMC, Amsterdam, The Netherlands.

The necessity of post-transplant monitoring for donor-specific antibodies (DSAs) is unclear. This study evaluates the clinical relevance of post-transplantation donor-specific HLA antibodies in pediatric renal transplant recipients, aiming at better stratification of patients at risk of graft dysfunction and better recommendations for post-transplant monitoring. A cohort of 68 pediatric kidney recipients, involving 76 transplantations between 2004 and 2014, was studied retrospectively. Read More

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http://dx.doi.org/10.1111/petr.13338DOI Listing
March 2019
1 Read

A social media editor for pediatric transplantation.

Pediatr Transplant 2019 02 11;23(1):e13343. Epub 2019 Jan 11.

Division of Pediatric Nephrology, Hypertension and Pheresis, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1111/petr.13343DOI Listing
February 2019
2 Reads

Impact of ventricular assist device implantation on the nutritional status of children awaiting heart transplantation.

Pediatr Transplant 2019 Mar 9;23(2):e13351. Epub 2019 Jan 9.

Department of Pediatrics (Cardiology), Stanford University School of Medicine, Palo Alto, California.

Background: Malnutrition is common in pediatric heart failure and is associated with mortality. The effect of VAD support on malnutrition in children is unknown. We sought to compare the prevalence and severity of malnutrition at HT in children on VAD support vs OMT to inform decisions regarding support strategies. Read More

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http://dx.doi.org/10.1111/petr.13351DOI Listing
March 2019
1 Read

Visceral artery anomalies in patients with Alagille syndrome.

Pediatr Transplant 2019 Mar 9;23(2):e13352. Epub 2019 Jan 9.

Department of Transplant Surgery, Jichi Medical University, Shimotsuke City, Tochigi, Japan.

Background: Intracranial and pulmonary vascular anomalies are well-known complications and causes of mortality in AGS; however, visceral artery anomalies are less commonly recognized. Herein, we present a retrospective analysis of our experience with pediatric LDLT that focuses on the current problems with and treatments for visceral artery anomalies in AGS after LDLT.

Methods: Between May 2001 and December 2017, 294 LDLTs were performed for 285 pediatric recipients. Read More

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http://dx.doi.org/10.1111/petr.13352DOI Listing
March 2019
3 Reads

Pediatric heart transplantation from an influenza B-positive donor.

Pediatr Transplant 2019 Mar 9;23(2):e13353. Epub 2019 Jan 9.

Division of Cardiology, Departments of Medicine and Pediatrics, Virginia School of Medicine, Charlottesville, Virginia.

As heart transplantation demand is increasing without subsequent growth of the donor pool, need for expansion of acceptance criteria is paramount, particularly when considering critically ill, highly sensitized patients. We present a case report of a pediatric heart transplant recipient of an organ refused by 197 prior potential recipients due to the donor being infected with influenza virus. We perform a literature review of recent solid organ transplant cases from influenza-positive donors and conclude that the donor pool may be expandable by allowing donors with treatable infections to be included. Read More

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March 2019
1 Read

Moderate-severe primary graft dysfunction after pediatric heart transplantation.

Pediatr Transplant 2019 Mar 4;23(2):e13340. Epub 2019 Jan 4.

Washington University School of Medicine/St. Louis Children's Hospital, St. Louis, Missouri.

Background: PGD is a complication after heart transplantation (OHT) and a significant cause of mortality, particularly in infant recipients. Lack of standardized definition of PGD in the pediatric population makes the prevalence and magnitude of impact unclear.

Methods: ISHLT PGD consensus guidelines, which include inotrope scores and need for MCS, were applied retrospectively to 208 pediatric OHT recipients from a single institution from 1/2005-5/2016. Read More

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http://dx.doi.org/10.1111/petr.13340DOI Listing
March 2019
1 Read

Risk stratification of immunocompromised children, including pediatric transplant recipients at risk of severe respiratory syncytial virus disease.

Pediatr Transplant 2019 Mar 3;23(2):e13336. Epub 2019 Jan 3.

Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Respiratory syncytial virus (RSV) infection is associated with increased morbidity and mortality in immunocompromised patients. Our goal was to develop a framework for risk stratifying immunocompromised patients, including transplant patients, for RSV prophylaxis.

Methods: Risk factors for severe RSV disease in immunocompromised patients were identified in the literature and by an expert panel via survey. Read More

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http://doi.wiley.com/10.1111/petr.13336
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http://dx.doi.org/10.1111/petr.13336DOI Listing
March 2019
7 Reads
1.630 Impact Factor

A preliminary investigation of sleep quality and patient-reported outcomes in pediatric solid organ transplant candidates.

Pediatr Transplant 2019 Mar 3;23(2):e13348. Epub 2019 Jan 3.

Department of Psychology, University of Georgia, Athens, Georgia.

The current cross-sectional, single-center study aimed to examine sleep quality in a sample of adolescents awaiting solid organ transplantation and to explore associations between sleep quality and both health-related quality of life and barriers to adherence. Thirty adolescents between the ages of 12 and 18 years (M age = 15.26, SD = 1. Read More

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http://dx.doi.org/10.1111/petr.13348DOI Listing
March 2019
1 Read
1.630 Impact Factor

The first successful pediatric heart transplant and results from the earliest era.

Pediatr Transplant 2019 Mar 1;23(2):e13349. Epub 2019 Jan 1.

Hosp for Sick Children, Toronto, Ontario, Canada.

Background: The first pediatric heart transplant died 5 hours after transplant and the case was published by Kantrowitz. There is no report of the first successful case in the medical literature, nor indeed the outcome of children transplanted prior to 1982. However, we recently discovered that children from this period were entered retrospectively into the ISHLT Registry when it began and they form the basis of this report. Read More

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March 2019
1 Read

Acute-on-chronic liver failure in children with biliary atresia awaiting liver transplantation.

Pediatr Transplant 2019 Mar 30;23(2):e13339. Epub 2018 Dec 30.

Paediatric Liver, Gastroenterology and Nutrition Centre, King's College Hospital, London, UK.

Objectives: Acute-on-chronic liver failure (ACLF) is an acute decompensation of cirrhosis complicated by other organ failure and is associated with increased mortality and morbidity. ACLF has not been studied in children with biliary atresia (BA), which is the commonest indication for pediatric liver transplantation (LT) worldwide. This study aims to evaluate ACLF and outcomes in children with BA while awaiting deceased donor LT. Read More

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http://dx.doi.org/10.1111/petr.13339DOI Listing
March 2019
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Outcomes of kidney transplants in pediatric patients with the vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities association.

Pediatr Transplant 2019 Mar 30;23(2):e13341. Epub 2018 Dec 30.

Division of Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

In this single-center retrospective study, we analyzed kidney transplant outcomes in nine pediatric patients with VACTERL [vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities] association-making this the largest study of its kind. Of 743 pediatric kidney transplant recipients at our center (1980-2017), nine had documented diagnoses of VACTERL association. All nine had congenital anorectal malformations and renal anomalies, five had vertebral defects, and one had a bifid thumb and tracheoesophageal fistula. Read More

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March 2019
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Growth of pediatric recipients after renal transplantation from small pediatric deceased donors weighing less than 15 kg.

Pediatr Transplant 2019 02 28;23(1):e13306. Epub 2018 Dec 28.

Department of Organ Transplantation, Changhai Hospital, Second Military Medical University, Shanghai, China.

RTx is currently the best treatment for children with ESRD. This study retrospectively analyzed the outcomes of growth after RTx using the pediatric-to-pediatric allocation strategy and some factors that may affect it. From March 2012 to August 2016, 8 en bloc and 38 single pediatric RTxs were performed at our center using organs from small pediatric deceased donors (weight < 15 kg). Read More

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February 2019
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1.630 Impact Factor

Fatigue in pediatric liver transplant recipients and its impact on their quality of life.

Pediatr Transplant 2019 02 26;23(1):e13331. Epub 2018 Dec 26.

Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The aim of the study was to investigate the occurrence of fatigue in 100 pediatric liver transplant recipients aged 2-18 years and its impact on their health-related quality of life (HRQL). HRQL and fatigue were measured using the PedsQL 4.0 Inventory and the PedsQL Multidimensional Fatigue Scale, which encompasses three subscales: general fatigue, sleep/rest fatigue, and cognitive fatigue. Read More

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http://doi.wiley.com/10.1111/petr.13331
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http://dx.doi.org/10.1111/petr.13331DOI Listing
February 2019
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Donor-derived strongyloidiasis in a Saudi pediatric kidney transplant recipient: A case report and mini-review.

Pediatr Transplant 2019 Mar 21;23(2):e13315. Epub 2018 Dec 21.

Division of Pediatric Infectious Diseases, King Abdullah Specialized Children's Hospital (KASCH), National Guard Health Affairs, Riyadh, Saudi Arabia.

S. stercoralis infection has been identified as a donor-derived infection in cases of solid organ transplant among recipients with no prior risk factor for parasitic exposure. Worldwide and regional reports from the adult kidney transplant population highlight this indirect method of infection and caution about delayed diagnosis, severe complications, and death related to donor-derived S. Read More

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http://doi.wiley.com/10.1111/petr.13315
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http://dx.doi.org/10.1111/petr.13315DOI Listing
March 2019
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Successful liver transplantation using a whole liver graft with gallbladder agenesis: First report in pediatric liver transplantation.

Pediatr Transplant 2019 Mar 21;23(2):e13342. Epub 2018 Dec 21.

Paediatric and Adult Liver Transplantation Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Introduction: Gallbladder agenesis (GA) is a rare congenital condition, occurring in approximately 40/100.000. It is likely due to an embryologic mishap in the development of the gallbladder bud and can be associated with other congenital variations in biliary anatomy. Read More

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http://dx.doi.org/10.1111/petr.13342DOI Listing
March 2019
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Health-related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients.

Pediatr Transplant 2019 Mar 19;23(2):e13337. Epub 2018 Dec 19.

Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.

Purpose: The understanding of the HRQOL issues for parent donors of children who underwent LDLT is lacking. We evaluated the HRQOL of donor and non-donor parents, described their subjective experiences and identified factors associated with lower HRQOL post-donation.

Methods: This is a cross-sectional study of parent donors whose children underwent LDLT, using SF-36v2 Health Survey to measure HRQOL, and a self-developed questionnaire to evaluate their subjective experiences. Read More

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http://doi.wiley.com/10.1111/petr.13337
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http://dx.doi.org/10.1111/petr.13337DOI Listing
March 2019
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Health-related quality of life changes following renal transplantation in children.

Pediatr Transplant 2019 Mar 12;23(2):e13333. Epub 2018 Dec 12.

Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.

Background: Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL.

Methods: We performed a retrospective study using the PedsQL3. Read More

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http://dx.doi.org/10.1111/petr.13333DOI Listing
March 2019
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Acute cellular rejection treatment outcomes stratified by Banff grade in pediatric kidney transplant.

Pediatr Transplant 2019 Mar 7;23(2):e13334. Epub 2018 Dec 7.

Pediatric Nephrology at Children's Healthcare of Atlanta, Atlanta, Georgia.

Introduction: There are limited data to guide optimal treatment strategies for acute cellular rejection (ACR) based on Banff grade for pediatric kidney transplant recipients. This report reviews a large pediatric transplant center's experience with ACR.

Materials And Methods: A retrospective analysis of pediatric kidney transplant recipients at our center from 2007 to 2014 was performed. Read More

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March 2019
4 Reads