3,393 results match your criteria Pediatric Transplantation[Journal]


Educational needs in families of pediatric liver and kidney transplant recipients: A quality improvement project.

Pediatr Transplant 2019 Apr 14:e13412. Epub 2019 Apr 14.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

Parents of pediatric liver and kidney transplant recipients were surveyed regarding their current education plans (eg, Individualized Education Program, 504), satisfaction with these plans, and interest in educational support from the psychosocial transplant team. Survey results indicate high rates of IEP and 504 plans, academic and related services, and accommodations among this population. The majority of parents/guardians reported satisfaction with their child's current school plan and did not report need for additional transplant team support specific to school services on the survey measure. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13412
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http://dx.doi.org/10.1111/petr.13412DOI Listing
April 2019
1 Read

Plasma electrolyte imbalance in pediatric kidney transplant recipients.

Pediatr Transplant 2019 Apr 11:e13411. Epub 2019 Apr 11.

Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

Background: In current practice, pediatric kidney transplant recipients receive large volumes of intravenous fluid intraoperatively to establish allograft perfusion, and further fluid to replace urinary and insensible losses postoperatively. Acute electrolyte imbalance can result, with potential for neurological sequelae. We aimed to determine the incidence and severity of postoperative plasma electrolyte imbalance in pediatric kidney transplant recipients managed with the current standard intravenous crystalloid regimen. Read More

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http://dx.doi.org/10.1111/petr.13411DOI Listing
April 2019
1 Read

Kidney disease and organ transplantation in methylmalonic acidaemia.

Pediatr Transplant 2019 Apr 11:e13407. Epub 2019 Apr 11.

Department of Paediatrics, Western University, London, Ontario, Canada.

Objectives: MMA is associated with chronic tubulointerstitial nephritis and a progressive decline in GFR. Optimal management of these children is uncertain. Our objectives were to document the pre-, peri-, and post-transplant course of all children with MMA who underwent liver or combined liver-kidney transplant in our centers. Read More

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http://dx.doi.org/10.1111/petr.13407DOI Listing
April 2019
1 Read

Ofatumumab in post-transplantation recurrence of focal segmental glomerulosclerosis in a child.

Pediatr Transplant 2019 Apr 11:e13413. Epub 2019 Apr 11.

Children's Hospital at Montefiore, Bronx, New York.

FSGS is a potentially devastating form of nephrotic syndrome. Treatment of SRNS can be difficult, especially post-transplantation. The current therapy of post-transplant SRNS includes plasmapheresis, ACE-I, CNI, and monoclonal antibodies (rituximab). Read More

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http://dx.doi.org/10.1111/petr.13413DOI Listing
April 2019
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Feasibility of extracorporeal photopheresis in pediatric patients with graft-versus-host disease after hematopoietic stem cell transplantation.

Pediatr Transplant 2019 Apr 11:e13416. Epub 2019 Apr 11.

The Child and Adolescent Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Graft-versus-host disease (GVHD) is a main cause of morbidity and mortality following hematopoietic stem cell transplantation. The cumulative incidence of acute and chronic GVHD (aGVHD, cGVHD) reaches 30%-50% and 20% in pediatric populations, respectively. Prednisolone and/or calcineurin inhibitors (CNI) are first-line treatments, but no superior second-line treatment has yet been established. Read More

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http://dx.doi.org/10.1111/petr.13416DOI Listing
April 2019
2 Reads

Determination of risk factors affecting mortality in patients with gastrointestinal perforation after pediatric liver transplantation.

Pediatr Transplant 2019 Apr 11:e13415. Epub 2019 Apr 11.

Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya, Turkey.

Gastrointestinal perforation (GIP) is one of the most serious complications occurring after liver transplantation (LT), especially in pediatric patients. This study aimed to determine the risk factors affecting mortality in pediatric patients with GIP after LT. GIP developed in 37 (10%) of 370 pediatric patients who underwent LT at our institute. Read More

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http://dx.doi.org/10.1111/petr.13415DOI Listing
April 2019
1.630 Impact Factor

Extracorporeal membrane oxygenation use in the first 24 hours following pediatric heart transplantation: Incidence, risk factors, and outcomes.

Pediatr Transplant 2019 Apr 11:e13414. Epub 2019 Apr 11.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Primary graft dysfunction following HTx is associated with significant morbidity and mortality. This study aimed to assess the incidence of, risk factors for, and outcomes of children requiring ECMO within 24 hours of HTx. This study utilized a linked PHIS/SRTR database of pediatric HTx recipients (2002-2016). Read More

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http://dx.doi.org/10.1111/petr.13414DOI Listing
April 2019
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Unrelated donor hematopoietic stem cell transplantation for pediatric de novo acute myeloid leukemia with intermediate- or high-risk cytogenetics.

Pediatr Transplant 2019 Apr 6:e13397. Epub 2019 Apr 6.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The role of unrelated donor HSCT for children with de novo AML in CR1 is controversial. We performed this study to investigate the feasibility of unrelated donor HSCT who initially had intermediate- or high-risk cytogenetics. We retrospectively reviewed medical records of patients with AML who received unrelated HSCT in CR1 at Samsung Medical Center between November 2001 and January 2012. Read More

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http://dx.doi.org/10.1111/petr.13397DOI Listing
April 2019
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Strong expression of p53 protein in bone marrow samples after hematopoietic stem cell transplantation indicates risk of relapse in pediatric acute lymphoblastic leukemia patients.

Pediatr Transplant 2019 Apr 6:e13408. Epub 2019 Apr 6.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, CLINTEC, Stockholm, Sweden.

Background: For pediatric ALL patients that relapse or respond poorly to conventional chemotherapy treatment, HSCT is one treatment option. Still, relapse occurs in 30% of the children after HSCT. Mutations in the tumor suppressor gene TP53 which can lead to an altered p53 protein expression are rare at time of diagnosis of ALL, yet occur more frequent at relapse indicating a more aggressive disease. Read More

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http://dx.doi.org/10.1111/petr.13408DOI Listing
April 2019
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Use of a donor iliac vein graft for reconstruction of the inferior vena cava in liver transplantation for hepatoblastoma with caval extension.

Pediatr Transplant 2019 Apr 4:e13409. Epub 2019 Apr 4.

The Department of Surgery, The Children's Hospital Westmead, Part of the Sydney Children's Hospital Network, Westmead, New South Wales, Australia.

Complete microscopic tumor resection is critical for successful treatment of hepatoblastoma, and this may include when liver transplantation is required. For tumors involving the IVC or PV, complete resection should include the involved IVC or PV to ensure full tumor clearance. When this is required, the venous reconstruction at transplant or post-excision can be challenging. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13409
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http://dx.doi.org/10.1111/petr.13409DOI Listing
April 2019
2 Reads

Renal function after combined liver-kidney transplantation: A longitudinal study of pediatric and adult patients.

Pediatr Transplant 2019 Apr 1:e13400. Epub 2019 Apr 1.

The Finnish Red Cross Blood Service, Helsinki, Finland.

It has been proposed that the liver protects the kidney in CLKT. However, few studies have examined long-term renal function after CLKT and contrasted renal function of CLKT patients to KT patients beyond one year after transplantation. We studied long-term renal function of CLKT patients and compared renal function of CLKT patients to KT patients between one and five years after transplantation. Read More

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http://dx.doi.org/10.1111/petr.13400DOI Listing
April 2019
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Pressure gradients, laboratory changes, and outcomes with transjugular intrahepatic portosystemic shunts in pediatric portal hypertension.

Pediatr Transplant 2019 Apr 1:e13387. Epub 2019 Apr 1.

Division of Gastroenterology and Hepatology, Department of Pediatrics, University of Washington School of Medicine/Seattle Children's Hospital, Seattle, Washington.

Introduction: Indications for TIPS are well described in adults and involve complications of PHTN. Complications from PHTN are associated with PSG of > 12 mm Hg in adults. It is unclear if these parameters apply to children with PHTN. Read More

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http://dx.doi.org/10.1111/petr.13387DOI Listing
April 2019
2 Reads

Comparative pharmacokinetics of tacrolimus in stable pediatric allograft recipients converted from immediate-release tacrolimus to prolonged-release tacrolimus formulation.

Pediatr Transplant 2019 Apr 1:e13391. Epub 2019 Apr 1.

Astellas Pharma Europe Ltd, Chertsey, UK.

This study was a Phase II, open-label, multicenter, single-arm, cross-over study comparing the pharmacokinetics (PK) of tacrolimus in stable pediatric kidney, liver, or heart allograft recipients converted from immediate-release tacrolimus (IR-T) to prolonged-release tacrolimus (PR-T). In Days -30 to -1 of screening period, patients received their IR-T-based regimen; during Days 1-7, patients received study IR-T (same dose as screening). On Day 7, the first 24-hours PK profile was taken; patients were then converted to PR-T (1 mg:1 mg), with a second 24-hours PK profile taken on Day 14. Read More

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http://dx.doi.org/10.1111/petr.13391DOI Listing
April 2019
2 Reads

The experience of combined and sequential liver and kidney transplantation from a single living donor in patients with primary hyperoxaluria type 1.

Pediatr Transplant 2019 Apr 1:e13406. Epub 2019 Apr 1.

Department of Organ Transplantation, Acibadem Mehmet Ali Aydinlar University Atakent Hospital, Istanbul, Turkey.

LKT is the only effective treatment for PH1 because it replaces both the source (liver) and the target (kidney) of the disease. Most studies report on LKT in patients with PH1 from deceased donors. This study reports on five patients who underwent LKT from a single living  donor between April 2017 and March 2018. Read More

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http://dx.doi.org/10.1111/petr.13406DOI Listing
April 2019
1 Read

Intra-patient variability in tacrolimus exposure in pediatric liver transplant recipients: Evolution, risk factors, and impact on patient outcomes.

Pediatr Transplant 2019 Mar 27:e13388. Epub 2019 Mar 27.

Department of Pediatric Nephrology and Rheumatology, Ghent University Hospital, Ghent, Belgium.

Background: This study aims to investigate the evolution and factors associated with TAC IPV and its impact on patient outcomes in pediatric LT recipients.

Methods: This is a retrospective study including 41 children. The TAC IPV was expressed as the coefficient of variation and was calculated for years 1-5 following LT. Read More

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http://dx.doi.org/10.1111/petr.13388DOI Listing

Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient.

Pediatr Transplant 2019 Mar 27:e13394. Epub 2019 Mar 27.

Departments of Dermatology and Pediatrics, Oregon Health & Science University, Portland, Oregon.

Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin-colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9-year-old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. Read More

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http://dx.doi.org/10.1111/petr.13394DOI Listing
March 2019
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Is there a functional disadvantage to using the external iliac vessels for vascular anastomosis in children and adolescents undergoing renal transplantation?

Pediatr Transplant 2019 Mar 27:e13398. Epub 2019 Mar 27.

Division of Urology, Hospital for Sick Children and Department of Surgery, University of Toronto, Ontario, Canada.

Purpose: RT remains the best available strategy for addressing stage 5 chronic kidney disease in children and adolescents. Technical aspects of the procedure can have a clear impact on complications and health of the allograft, including DGF. Immediate optimal perfusion is paramount, thus choosing a target vessel has to take into account the flow demands imposed by an adult-size kidney in a proportionally smaller recipient. Read More

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http://dx.doi.org/10.1111/petr.13398DOI Listing

Transplantation of adult-size kidneys in small pediatric recipients: A single-center experience.

Pediatr Transplant 2019 Mar 27:e13401. Epub 2019 Mar 27.

Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.

RTx of adult-size kidneys presents a size mismatch in small pediatric recipients, and there are potential surgical complications. This study reveals the outcomes of intra- and extraperitoneal RTx in low-weight (less than 15 kg) pediatric recipients. We studied 51 pediatric patients weighing less than 15 kg who received a living-related donor renal transplant between 2009 and 2017. Read More

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http://dx.doi.org/10.1111/petr.13401DOI Listing
March 2019
1 Read

Development of hemolytic paroxysmal nocturnal hemoglobinuria without graft loss following hematopoietic stem cell transplantation for acquired aplastic anemia.

Pediatr Transplant 2019 Mar 22:e13393. Epub 2019 Mar 22.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

PNH is the most common clonal hematopoietic disorder arising in patients with aAA. PNH is caused by mutations in PIGA, a gene that encodes the catalytic subunit of an enzyme involved in the biosynthesis of GPI anchors, transmembrane glycolipids required for cell surface expression of many proteins. PNH clones likely arise as immune escape mechanisms in aAA by preventing CD1D-restricted T-cell recognition of GPI anchors and GPI-linked autoantigens. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13393
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http://dx.doi.org/10.1111/petr.13393DOI Listing
March 2019
4 Reads

Novel insights into the assessment of risk of upper gastrointestinal bleeding in decompensated cirrhotic children.

Pediatr Transplant 2019 Mar 19:e13390. Epub 2019 Mar 19.

Service de gastroentérologie et hépatologie pédiatrique, Département de pédiatrie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgique.

Objectives: Cirrhotic children wait-listed for liver transplant are prone to bleeding from gastrointestinal varices. Grade 2-3 esophageal varices, red signs, and gastric varices are well-known risk factors. However, the involvement of hemostatic factors remains controversial because of the rebalanced state of coagulation during cirrhosis. Read More

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http://dx.doi.org/10.1111/petr.13390DOI Listing
March 2019
3 Reads

Isolated abdominal nocardiosis in a pediatric renal transplant recipient.

Pediatr Transplant 2019 Mar 19:e13392. Epub 2019 Mar 19.

Division of Pediatric Nephrology, Department of Pediatrics, University Florida, Gainesville, Florida.

Nocardia infection after RT is uncommon. The most common modes of exposure are inhalation of dust containing nocardia or contaminated soil/water and surgical instruments. Isolated abdominal nocardiosis following RT has not been reported. Read More

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http://dx.doi.org/10.1111/petr.13392DOI Listing
March 2019
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A clinical description of children with solid organ transplants who present with feeding disorder.

Pediatr Transplant 2019 Mar 18:e13389. Epub 2019 Mar 18.

Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, Milwaukee, Wisconsin.

Pediatric solid organ transplant recipients have long-standing malnutrition concerns related to their pretransplant medical status. The targeted nutrition therapy utilized pre-, peri-, and post-transplantation may have the adverse effect of impeding normally developing feeding skills, particularly in very young children. Little is known about the relationship between transplantation and feeding disorders of childhood. Read More

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http://dx.doi.org/10.1111/petr.13389DOI Listing
March 2019
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Satisfactory usage of kidneys from pediatric donors with severe hand foot mouth disease.

Pediatr Transplant 2019 Mar 18:e13386. Epub 2019 Mar 18.

Department of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.

No studies have reported making use of kidneys from pediatric donors with severe HFMD. Here, we retrospectively analyzed the feasibility and clinical effect of six cases of kidney transplantation from four pediatric donors with severe HFMD in our center between January 2014 and December 2016. The donors' age ranged from 6 months to 3 years and 11 months. Read More

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http://dx.doi.org/10.1111/petr.13386DOI Listing
March 2019
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Incidence, clinical features, and outcomes of food allergy in children who underwent liver transplant: 16-year experience.

Pediatr Transplant 2019 Mar 18:e13399. Epub 2019 Mar 18.

Department of General Surgery and Transplant Surgery, Başkent University Hospital, Ankara, Turkey.

Food allergies often develop after liver transplant, especially in young children. However, data are scarce on clinical characteristics and patient outcomes. When we evaluated our pediatric liver transplant patients over a 16-year period, food allergy incidence was 8% (19/236 patients). Read More

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http://dx.doi.org/10.1111/petr.13399DOI Listing
March 2019
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Right atrial function in pediatric heart transplant patients by echocardiographic strain measurements.

Pediatr Transplant 2019 Mar 13:e13383. Epub 2019 Mar 13.

Division of Cardiology, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.

Background: CAV is a major cause of mortality in PHTx patients. Research on echocardiographic indices to detect CAV focuses primarily on ventricular function and less is known about RAF. Thus, we primarily sought to evaluate RAF in PHTx patients with CAV. Read More

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http://dx.doi.org/10.1111/petr.13383DOI Listing

Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

Pediatr Transplant 2019 Mar 6:e13384. Epub 2019 Mar 6.

Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. Read More

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http://dx.doi.org/10.1111/petr.13384DOI Listing
March 2019
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Infections among pediatric transplant candidates: An approach to decision-making.

Pediatr Transplant 2019 Mar 5:e13375. Epub 2019 Mar 5.

The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Introduction: The presence of infections in the immediate pretransplant period poses challenges in decision-making. Delaying transplantation because of these infections may be required, but is associated with a risk to the potential recipient. The aim of this project was to develop a structured framework based on expert opinion to guide decision-making regarding the safety of transplantation for candidates with infection immediately before transplant, and to show how this framework can be applied to clinical scenarios. Read More

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http://dx.doi.org/10.1111/petr.13375DOI Listing
March 2019
1 Read
1.630 Impact Factor

Severe, persistent neurotoxicity after transplant-associated thrombotic microangiopathy in a pediatric patient despite treatment with eculizumab.

Pediatr Transplant 2019 Mar 3:e13381. Epub 2019 Mar 3.

Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.

Background: TA-TMA is a described complication of aHCT in children with neuroblastoma. Outcomes are poor with mortality rates approaching 60%. Described late effects in survivors include chronic kidney disease and persistent pulmonary hypertension. Read More

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http://dx.doi.org/10.1111/petr.13381DOI Listing
March 2019
7 Reads

European Society of Pediatric Nephrology survey on current practice regarding recurrent focal segmental glomerulosclerosis after pediatric kidney transplantation.

Pediatr Transplant 2019 Mar 1:e13385. Epub 2019 Mar 1.

Division of Nephrology and Dialysis, Bambino Gesù Children's Hospital and Research Institute, Rome, Italy.

Introduction: Primary FSGS is an important cause of ESRD in children. FSGS recurrence after kidney transplantation is associated with early graft loss. No guidelines for treatment of FSGS recurrence exist. Read More

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http://dx.doi.org/10.1111/petr.13385DOI Listing
March 2019
1 Read

First report of successful transplantation of a pediatric donor liver graft after hypothermic machine perfusion.

Pediatr Transplant 2019 Feb 22:e13362. Epub 2019 Feb 22.

Department of Surgery, Section of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, The Netherlands.

One of the main limiting factors in pediatric liver transplantation is donor availability. For adults, DCD liver grafts are increasingly used to expand the donor pool. To improve outcome after DCD liver transplantation, ex situ machine perfusion is used as an alternative organ preservation strategy, with the supplemental value of providing oxygen to the graft during preservation. Read More

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http://dx.doi.org/10.1111/petr.13362DOI Listing
February 2019

Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases.

Pediatr Transplant 2019 Feb 21:e13379. Epub 2019 Feb 21.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Database linkage is a common strategy to expand analytic possibilities. Our group recently completed a linkage between the SRTR and PHIS databases for pediatric heart transplant recipients. The aim of this project was to expand the linkage between SRTR and PHIS to include liver, kidney, lung, heart-lung, and small bowel transplants. Read More

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http://dx.doi.org/10.1111/petr.13379DOI Listing
February 2019

Post-transplant metabolic syndrome in children: Know better to cure better.

Pediatr Transplant 2019 Feb 21:e13367. Epub 2019 Feb 21.

Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Gesù Children's Research Hospital IRCCS, Rome, Italy.

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http://dx.doi.org/10.1111/petr.13367DOI Listing
February 2019

Successful hematopoietic stem cell transplantation from an HLA-mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases.

Pediatr Transplant 2019 Feb 20:e13378. Epub 2019 Feb 20.

Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

JMML is an aggressive hematopoietic malignancy of early childhood, and allogeneic HSCT is the only curative treatment for this disease. Umbilical cord blood is one of donor sources for HSCT in JMML patients who do not have an HLA-compatible relative, but engraftment failure remains a major problem. Here, we report two cases of JMML who were successfully rescued by HSCT from an HLA-mismatched parent after development of primary engraftment failure following unrelated CBT. Read More

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http://dx.doi.org/10.1111/petr.13378DOI Listing
February 2019

Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis.

Pediatr Transplant 2019 Feb 20:e13382. Epub 2019 Feb 20.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Background: CMV is associated with adverse effects in renal transplant recipients. The objective of this study was to characterize the incidence and timing of CMV and EBV infections in relation to valGCV prophylaxis in a pediatric renal transplant cohort.

Methods: Retrospective cohort of pediatric renal transplant patients given universal valGCV prophylaxis and universal viral surveillance was evaluated. Read More

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http://dx.doi.org/10.1111/petr.13382DOI Listing
February 2019

Psychotropic medication use trends in a large pediatric and young adult solid organ transplant population.

Pediatr Transplant 2019 Feb 20:e13380. Epub 2019 Feb 20.

Boston Children's Hospital Department of Psychiatry, Boston, Massachusetts.

Introduction: This study describes psychotropic medication use in a pediatric and young adult solid organ transplant population.

Methods: We conducted a retrospective review of the lifetime incidence of psychotropic medication use and associated characteristics in patients seen over a 6-year period at a large pediatric transplant center utilizing univariate and multivariate statistical analyses.

Results: The lifetime incidence of psychotropic medication use was 36. Read More

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http://dx.doi.org/10.1111/petr.13380DOI Listing
February 2019
2 Reads

Hematopoietic stem cell transplantation in children with sickle cell anemia: The parents' experience.

Pediatr Transplant 2019 Feb 20:e13376. Epub 2019 Feb 20.

Department of Psychopathology, Avicenne Hospital, Paris XIII University & Assistance Publique-Hôpitaux de Paris, Bobigny, France.

Genoidentical HSCT is currently the only curative treatment for SCA, preventing further vascular complications in high-risk children. Studies on the psychological implications of HSCT for recipient, sibling donor, and the rest of the family have been limited in SCA. This study enrolled ten families and used semi-structured interviews to explore the parents' experience at three time points: first before transplantation, then 3 months later, and 1 year later. Read More

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http://dx.doi.org/10.1111/petr.13376DOI Listing
February 2019
1 Read

Gastrostomy tubes appear to be safe following pediatric orthotopic heart transplant.

Pediatr Transplant 2019 Feb 20:e13374. Epub 2019 Feb 20.

Division of Pediatric Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.

Background: Gastrostomy tube (GT) placement is a common pediatric surgical procedure typically indicated for oral aversion. This may develop in patients with congenital heart disease (CHD) who require an orthotopic heart transplant (OHT). The safety profile of GT placement in OHT patients who are immunosuppressed is unknown. Read More

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http://doi.wiley.com/10.1111/petr.13374
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http://dx.doi.org/10.1111/petr.13374DOI Listing
February 2019
8 Reads

Sequential transplantation and implications for clinical management: OLT followed by HCT and consequent RT in a pediatric patient.

Pediatr Transplant 2019 Feb 18:e13370. Epub 2019 Feb 18.

Section of Hematology, Oncology and BMT, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

We report a case of a pediatric patient who required three separate transplants: OLT at the age 5, HCT at age 13 (8 years post-OLT), and cadaveric RT at age 15 (10 years post-OLT). The child initially presented with fulminant liver failure without known cause, ultimately undergoing OLT from his mother. He then developed SAA, for which he required HCT. Read More

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http://dx.doi.org/10.1111/petr.13370DOI Listing
February 2019
1 Read

Single kidney transplantation from donors with acute kidney injury: A single-center experience.

Pediatr Transplant 2019 Feb 15:e13326. Epub 2019 Feb 15.

Department of Urology, West China Hospital, Sichuan University, Chengdu, China.

Introduction: Despite a severe shortage of organ supply, patients are reluctant to accept organs from deceased donors with AKI, let alone from pediatric AKI donors.

Methods: We assessed 70 patients who received kidneys from donors with AKI (10 with pediatric and 60 with adult donors) and 176 contemporaneous patients who received kidneys from non-AKI donors (41 with pediatric and 135 with adult donors) between March 2012 and February 2017 for retrospectively evaluating the clinical outcomes.

Results: AKI was defined and staging by the RIFLE criteria and pediatric-modified RIFLE criteria. Read More

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http://dx.doi.org/10.1111/petr.13326DOI Listing
February 2019
11 Reads
1.630 Impact Factor

The T-helper cells 17 instead of Tregs play the key role in acute rejection after pediatric liver transplantation.

Pediatr Transplant 2019 Feb 12:e13363. Epub 2019 Feb 12.

Department of Transplant Surgery, Tianjin First Center Hospital, Tianjin, China.

Th17 and imbalance of Treg/Th17 might be one of the mechanisms of acute rejection. We aim to explore the role of Th17s in the balance of Treg/Th17 in acute rejection after LT in children diagnosed with BA. The ratios of Treg and Th17 in peripheral blood were detected by flow cytometry pre-LT, post-LT, and when rejection occurred. Read More

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http://doi.wiley.com/10.1111/petr.13363
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http://dx.doi.org/10.1111/petr.13363DOI Listing
February 2019
9 Reads

Comparison of 10-year graft failure rates after induction with basiliximab or anti-thymocyte globulin in pediatric heart transplant recipients-The influence of race.

Pediatr Transplant 2019 Feb 8:e13366. Epub 2019 Feb 8.

Division of Pediatric Cardiothoracic Surgery, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background/objective: The impact of induction therapy in pediatric heart transplantation has been uncertain. Given the risk of poor outcomes in black pediatric heart transplant recipients, we evaluated the effect on graft survival of ATG and BAS induction in black and non-black pediatric recipients.

Methods: This was a retrospective analysis of pediatric candidates (aged ≤18 years) who underwent heart transplantation from 2000 to 2016 identified from the UNOS database. Read More

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http://dx.doi.org/10.1111/petr.13366DOI Listing
February 2019
1 Read

A comparison of post-transplant renal function in pre-emptive and post-dialysis pediatric kidney transplant recipients.

Pediatr Transplant 2019 Feb 8:e13377. Epub 2019 Feb 8.

Division of Urology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: Little is known regarding post-transplant renal function following pediatric pre-emptive KT. Therefore, this study aims to determine whether there is a difference in 1 year post-transplant renal function outcomes between pre-emptive and post-dialysis KT in pediatric transplant recipients.

Methods: A retrospective review of patients who underwent kidney transplant at our institution between 2000 and 2015 was performed. Read More

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February 2019
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Communication about prognosis and end-of-life in pediatric organ failure and transplantation.

Pediatr Transplant 2019 Feb 7:e13373. Epub 2019 Feb 7.

Department of Pediatrics, Michigan Medicine, Ann Arbor, Michigan.

Background: Despite advancements in treatment and survival, pediatric organ failure and transplant populations continue to face significant risks of morbidity and mortality. Little scientific attention has been given to addressing the end-of-life care needs of this growing population of young people. This study characterized current practices, beliefs, and challenges specific to the disclosure of prognosis and end-of-life care topics among providers caring for pediatric organ failure and transplant populations. Read More

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http://dx.doi.org/10.1111/petr.13373DOI Listing
February 2019

"Inverted" positioning of renal allograft during kidney transplantation in children and adolescents: A single-institution comparative analysis.

Pediatr Transplant 2019 Feb 7:e13365. Epub 2019 Feb 7.

Department of Urology, Hospital for Sick Children, Toronto, Ontario, Canada.

Renal transplantation is the treatment of choice in children with end-stage renal failure. Limitations in patient anatomy or a short donor renal vein may necessitate intraoperative inversion of the kidney. There is little evidence to support the use of this surgical technique, and no evidence in the pediatric population. Read More

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http://dx.doi.org/10.1111/petr.13365DOI Listing
February 2019

Compassionate deactivation of ventricular assist devices in children: A survey of pediatric ventricular assist device clinicians' perspectives and practices.

Pediatr Transplant 2019 Feb 7:e13359. Epub 2019 Feb 7.

Department of Cardiology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts.

Objectives: This study's objective was to investigate compassionate ventricular assist device deactivation (VADdeact) in children from the perspective of the pediatric heart failure provider.

Background: Pediatric VAD use is a standard therapy for advanced heart failure. Serious adverse events may affect relative benefit of continued support, leading to consideration of VADdeact. Read More

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http://dx.doi.org/10.1111/petr.13359DOI Listing
February 2019
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Development of a multinational registry of pediatric deceased organ donation activity.

Pediatr Transplant 2019 Feb 5:e13345. Epub 2019 Feb 5.

Deceased Donation, Canadian Blood Services, Ottawa, Ontario, Canada.

Background: There are no currently agreed upon international standards for reporting of pediatric deceased organ donation activity. This leads to difficulty in comparisons between jurisdictions for both researchers and policy stakeholders. The goal of this project was to develop and test a standardized registry for pediatric deceased donation activity. Read More

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http://dx.doi.org/10.1111/petr.13345DOI Listing
February 2019

Early post-operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus.

Pediatr Transplant 2019 Feb 4:e13368. Epub 2019 Feb 4.

Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

We aimed to compare the early results of i.v. with p. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13368
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http://dx.doi.org/10.1111/petr.13368DOI Listing
February 2019
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Indications and efficacy of conversion from tacrolimus- to sirolimus-based immunosuppression in pediatric patients who underwent liver transplantation for unresectable hepatoblastoma.

Pediatr Transplant 2019 Feb 4:e13369. Epub 2019 Feb 4.

Department of Surgery, Children's Mercy Hospital, Kansas City, Missouri.

SRL-based immunosuppressive strategies in pediatric liver transplantation are not clearly defined, especially within the first year after liver transplant. TAC is the more common, traditional immunosuppressant used. However, SRL may modulate TAC-associated kidney injury and may also have antiproliferative properties that are valuable in the management of patients following liver transplantation for HB. Read More

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http://dx.doi.org/10.1111/petr.13369DOI Listing
February 2019
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Non-invasive differentiation of non-rejection kidney injury from acute rejection in pediatric renal transplant recipients.

Pediatr Transplant 2019 Feb 4:e13364. Epub 2019 Feb 4.

Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

Acute kidney injury (AKI) is a major concern in pediatric kidney transplant recipients, where non-alloimmune causes must be distinguished from rejection. We sought to identify a urinary metabolite signature associated with non-rejection kidney injury (NRKI) in pediatric kidney transplant recipients. Urine samples (n = 396) from 60 pediatric transplant participants were obtained at time of kidney biopsy and quantitatively assayed for 133 metabolites by mass spectrometry. Read More

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http://dx.doi.org/10.1111/petr.13364DOI Listing
February 2019
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Ovarian function after allogeneic hematopoietic stem cell transplantation in children and young adults given 8-Gy total body irradiation-based reduced-toxicity myeloablative conditioning.

Pediatr Transplant 2019 Feb 3:e13372. Epub 2019 Feb 3.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Background: The spectrum of late sequelae after hematopoietic stem cell transplantation (HSCT) includes infertility, which is the most frequent complication. Some reports suggested that ovarian function may be better preserved in females undergoing HSCT with reduced-intensity conditioning (RIC) than with conventional myeloablative conditioning (MAC). However, the impact of HSCT after 8-Gy TBI-based reduced-toxicity MAC (RTMAC), whose efficacy is between those of conventional MAC and RIC, on ovarian function remains unclear. Read More

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http://dx.doi.org/10.1111/petr.13372DOI Listing
February 2019
3 Reads