705,324 results match your criteria Pediatric Sinusitis Medical Treatment


Assessment of Exercise Capacity in Children with Type 1 Diabetes in the Cooper Running Test.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland.

Regular physical activity increases lifespan for those with type 1 diabetes. However, disease-related barriers may deter children from exercise and affect their fitness. This study examined the safety of the Cooper test concerning diabetes-related acute complications in children with type 1 diabetes and their fitness. Read More

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December 2018

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease.

Am J Nephrol 2018 Dec 17;49(1):54-63. Epub 2018 Dec 17.

Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya,

Background: In pediatric patients with steroid-sensitive nephrotic syndrome, recent trials have revealed that a 2-month, short-term steroid regimen is not inferior to an extended steroid course. However, the optimal duration of initial steroid therapy for adult steroid-sensitive minimal change disease (MCD) remains unclear.

Objectives: The aim of present study was to evaluate the effectiveness of a 2-month, short-term steroid regimen in the treatment of adult steroid-sensitive MCD patients. Read More

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December 2018

EDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Tetralogy of Fallot: diagnosis to long-term follow-up.

Authors:
R Bedair X Iriart

Echo Res Pract 2019 Mar;6(1):R9-R23

Department of Pediatric and Adult Congenital Cardiology, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Pessac, France.

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect, affecting 3 in 10,000 live births. Surgical correction in early childhood is associated with good outcomes, but lifelong follow-up is necessary to identify the long-term sequelae that may occur. This article will cover the diagnosis of TOF in childhood, the objectives of surveillance through adulthood and the value of multi-modality imaging in identifying and guiding timely surgical and percutaneous interventions. Read More

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Epilepsy and seizures in children with congenital heart disease: A prospective study.

Seizure 2018 Nov 26;64:50-53. Epub 2018 Nov 26.

Clinique d'Investigation Neuro-Cardiaque (CINC), CHU Sainte-Justine, Montreal, Canada.

Purpose: Children with complex congenital heart disease (CHD) experience high incidence of perioperative seizures. Population-based studies also report high epilepsy co-morbidity in CHD. Given the increasing survival of patients with CHD and the interference of seizures and epilepsy with the long-term outcomes, characterizing them in this population is of high relevance. Read More

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November 2018

Brain activity in struggling readers before intervention relates to future reading gains.

Cortex 2018 Nov 16;111:286-302. Epub 2018 Nov 16.

Department of Psychology, The University of Texas at Austin, Austin, TX, USA; Biomedical Imaging Center, The University of Texas at Austin, Austin, TX, USA.

Neural markers for reading-related changes in response to intervention could inform intervention plans by serving as a potential index of the malleability of the reading network in struggling readers. Of particular interest is the role of brain activation outside the reading network, especially in executive control networks important for reading comprehension. However, it is unclear whether any intervention-related executive control changes in the brain are specific to reading tasks or reflect more domain general changes. Read More

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November 2018

Long-term ketone body therapy of severe multiple acyl-CoA dehydrogenase deficiency: A case report.

Nutrition 2018 Oct 22;60:122-128. Epub 2018 Oct 22.

University Hospital Muenster, Department of Pediatrics, Muenster, Germany.

Objectives: Multiple acyl-CoA dehydrogenase deficiency (MADD) is the most severe disorder of mitochondrial fatty acid β-oxidation. Treatment of this disorder is difficult because the functional loss of the electron transfer flavoprotein makes energy supply from fatty acids impossible. Acetyl-CoA, provided by exogenous ketone bodies such as NaßHB, is the only treatment option in severe cases. Read More

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October 2018

Current management of pediatric chiari type 1 malformations.

Clin Neurol Neurosurg 2018 Dec 10;176:122-126. Epub 2018 Dec 10.

Department of Neurosurgery, Albany Medical College, Albany, NY, USA.

Objectives: Pediatric Chiari Type 1 Malformations (CM1) are commonly referred for neurosurgical opinion. The ideal management in children regarding surgical and radiographic decision making is not clearly delineated.

Patients And Methods: We retrospectively reviewed our cohort of patients age 18 years and younger referred to a single neurosurgeon for CM1. Read More

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December 2018

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: The most common immediate hypersensitivity to macrogols is associated with PEG 3350, however the epidemiology, mechanisms and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.

Objective: Our objective was to better understand the mechanism, cross-reactivity and scope of PEG hypersensitivity. Read More

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December 2018
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Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts.

Environ Res 2018 Dec 7;170:73-81. Epub 2018 Dec 7.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, member DZL, German Center for Lung Research, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Electronic address:

Background: Depression has been associated with air pollution, as reported by animal and epidemiological studies. However, the relationship between ozone exposure and depression, especially among adolescents, is scarcely investigated.

Objectives: The study aimed to analyze associations between ozone exposure and depressive symptoms among German adolescents. Read More

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December 2018

Insurance Approval for Proton Beam Therapy and its Impact on Delays in Treatment.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ. Electronic address:

Purpose: Prior authorization (PA) has been widely implemented for proton beam therapy (PBT). We sought to determine the association between PA determination and patient characteristics, practice guidelines, and potential treatment delays.

Methods And Materials: A single-institution retrospective analysis was performed of all patients considered for PBT between 2015 and 2018 at a National Cancer Institute-designated Comprehensive Cancer Center. Read More

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December 2018

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech Building, Biocant Park, 3060-197, Cantanhede, Portugal. Electronic address:

Dose-dependent and cumulative cardiotoxicity associated with doxorubicin (DOX) is the main limitation of anticancer therapy. Pediatric cancer survivors are particularly vulnerable, and no effective prevention measures are available. The aim of the present study was to investigate the persistent effects of nanomolar DOX concentrations and determine whether a pretreatment would induce mitochondrial adaptations in H9c2 cardiomyoblasts. Read More

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December 2018

A papilloma in a large cyst of the breast: A case report.

Int J Surg Case Rep 2018 Nov 16;55:1-3. Epub 2018 Nov 16.

Department of Pediatric, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, South Korea. Electronic address:

Introduction: Intracystic lesions of the breast prove to be benign more often than malignancy, most intracystic lesions are benign papillomas. Generally sizes of cysts that contain papilloma are small. Relatively cysts that contain papillary carcinoma are large. Read More

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November 2018

Body composition and bone mineral density in childhood.

Bone 2018 Dec 14. Epub 2018 Dec 14.

Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA; Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA.

Background: Body mass compartments may have different directions of influence on bone accrual. Studies of children are limited by relatively small sample sizes and typically make strong assumptions of linear regression.

Objective: To evaluate associations of overall body mass, components of overall body mass (fat-free and total fat), and components of total fat mass (truncal and non-truncal fat), measured via dual-energy X-ray absorptiometry (DXA) and anthropometry, with total body less head areal bone mineral density (aBMD) Z-score in mid-childhood. Read More

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December 2018

A tale of two steroids: the importance of the androgens DHEA and DHEAS for early neurodevelopment.

J Steroid Biochem Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

School of Health & Biomedical Sciences, RMIT University - Bundoora Campus, Melbourne, 3083, Australia. Electronic address:

DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor system in the brain, including sigma (σ), glutamate, and GABA-A receptors. It has been recognized as early as 1952, that the loss of DHEA/DHEAS in adult life is associated with neuropsychiatric disorders (eg schizophrenia, depression). However, the mechanistic role for DHEA/DHEAS in any of these domains remains speculative, not the least because the presence of these androgens in the adrenal gland and brain is largely confined to humans and only some non-human primates. Read More

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December 2018

Inositol hexakisphosphate increases the size of platelet aggregates.

Biochem Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52 D-20246 Hamburg, Germany. Electronic address:

The inositol phosphates, InsP and InsP, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP concentration upon stimulation with the PLC-activating agonists thrombin, collagen I and ADP and present a fraction of it at the outer plasma membrane. Cone and plate analysis in whole blood revealed that InsP specifically increases platelet aggregate size. Read More

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December 2018

One-Year Survival and Neurologic Outcomes after Pediatric Open-Chest Cardiopulmonary Resuscitation.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.

Background: Limited data exist regarding neurobehavioral outcomes of children treated with open-chest cardiopulmonary resuscitation (CPR). Our objective was to describe neurobehavioral outcomes one year post-arrest among children who received open-chest CPR during in-hospital cardiac arrest; and explore factors associated with one-year survival and survival with good neurobehavioral outcome.

Methods: The study is a secondary analysis of the Therapeutic Hypothermia after Pediatric Cardiac Arrest In-Hospital Trial. Read More

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December 2018

Variation in Implementation and Outcomes of Early Extubation Practices After Infant Cardiac Surgery.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Michigan Medicine C.S. Mott Children's Hospital, Department of Pediatrics, 1540 E. Hospital Drive, Ann Arbor, MI 48109.

Background: The Pediatric Heart Network Collaborative Learning Study (PHN CLS) increased early extubation after infant Tetralogy of Fallot (TOF) and coarctation repair overall at participating sites through implementing a clinical practice guideline (CPG). We evaluated variability across sites in CPG implementation and outcomes.

Methods: Patient characteristics and outcomes [time to extubation, length of stay (LOS)] were compared across sites, including pre- to post-CPG changes. Read More

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December 2018

Taking Precise Aim at Lung Disease.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

The Cleveland Clinic, Center for Pediatric Research, Cleveland, Ohio, United States ;

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December 2018

Movement Disorders in Treatable Inborn Errors of Metabolism.

Mov Disord 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

There are several hundred single-gene disorders that we classify as inborn errors of metabolism. Inborn errors of metabolism are often rare and highly heterogeneous multisystem diseases with non-neurological and neurological manifestations, commonly with onset during childhood. Movement disorders are among the most common neurological problems in inborn errors of metabolism, but, in many cases, remain poorly defined. Read More

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December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

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December 2018

Increasing the diagnostic yield of exome sequencing by copy number variant analysis.

PLoS One 2018 17;13(12):e0209185. Epub 2018 Dec 17.

Department of Genetics, University of North Carolina, Chapel Hill, NC, United States of America.

As whole exome sequencing (WES) becomes more widely used in the clinical realm, a wealth of unanalyzed information will be routinely generated. Using WES read depth data to predict copy number variation (CNV) could extend the diagnostic utility of this previously underutilized data by providing clinically important information such as previously unsuspected deletions or duplications. We evaluated ExomeDepth, a free R package, in addition to an aneuploidy prediction method, to detect CNVs in WES data. Read More

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December 2018

GSK-3 inhibitors enhance TRAIL-mediated apoptosis in human gastric adenocarcinoma cells.

PLoS One 2018 17;13(12):e0208094. Epub 2018 Dec 17.

Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.

Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis has been reported in some cancer cells, including AGS human gastric adenocarcinoma cells. Reducing this resistance might shed light on the treatment of human gastric adenocarcinoma. In this study, we examined whether glycogen synthase kinase-3 (GSK-3) inhibitors can restore TRAIL responsiveness in gastric adenocarcinoma cells. Read More

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December 2018

Familial episodic limb pain in kindreds with novel Nav1.9 mutations.

PLoS One 2018 17;13(12):e0208516. Epub 2018 Dec 17.

Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these episodes. As no term described this syndrome (familial episodic pain: FEP) in Japanese, we named it as". Read More

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December 2018

Peer-assisted learning after onsite, low-dose, high-frequency training and practice on simulators to prevent and treat postpartum hemorrhage and neonatal asphyxia: A pragmatic trial in 12 districts in Uganda.

PLoS One 2018 17;13(12):e0207909. Epub 2018 Dec 17.

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

An urgent need exists to improve and maintain intrapartum skills of providers in sub-Saharan Africa. Peer-assisted learning may address this need, but few rigorous evaluations have been conducted in real-world settings. A pragmatic, cluster-randomized trial in 12 Ugandan districts provided facility-based, team training for prevention and management of postpartum hemorrhage and birth asphyxia at 125 facilities. Read More

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December 2018

Cell-intrinsic regulation of peripheral memory-phenotype T cell frequencies.

PLoS One 2018 17;13(12):e0200227. Epub 2018 Dec 17.

National Institute of Immunology, New Delhi, India.

Memory T and B lymphocyte numbers are thought to be regulated by recent and cumulative microbial exposures. We report here that memory-phenotype lymphocyte frequencies in B, CD4 and CD8 T-cells in 3-monthly serial bleeds from healthy young adult humans were relatively stable over a 1-year period, while Plasmablast frequencies were not, suggesting that recent environmental exposures affected steady state levels of recently activated but not of memory lymphocyte subsets. Frequencies of memory B and CD4 T cells were not correlated, suggesting that variation in them was unlikely to be determined by cumulative antigenic exposures. Read More

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December 2018

Quantitative RNAseq analysis of Ugandan KS tumors reveals KSHV gene expression dominated by transcription from the LTd downstream latency promoter.

PLoS Pathog 2018 Dec 17;14(12):e1007441. Epub 2018 Dec 17.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

KSHV is endemic in Uganda and the HIV epidemic has dramatically increased the incidence of Kaposi sarcoma (KS). To investigate the role of KSHV in the development of KS, we obtained KS biopsies from ART-naïve, HIV-positive individuals in Uganda and analyzed the tumors using RNAseq to globally characterize the KSHV transcriptome. Phylogenetic analysis of ORF75 sequences from 23 tumors revealed 6 distinct genetic clusters with KSHV strains exhibiting M, N or P alleles. Read More

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December 2018

Hepatitis E virus seroprevalence and determinants in various study populations in the Netherlands.

PLoS One 2018 17;13(12):e0208522. Epub 2018 Dec 17.

Department of Infectious Diseases, Public Health Service Amsterdam (GGD), Amsterdam, the Netherlands.

Background: The epidemiology of hepatitis E virus (HEV) is not fully understood. In this study, we assessed putative risk factors for HEV seropositivity in various study populations in the Netherlands.

Methods: Data and samples from five different study populations were analysed: (A) blood donors (n = 5,239), (B) adults reporting a vegetarian life style since the age of 12 years (n = 231), (C) residents of Amsterdam, the Netherlands, with different ethnic backgrounds (n = 1,198), (D) men who have sex with men (MSM) (HIV positive and HIV negative) (n = 197), and (E) persons who use drugs (PWUD) (HIV positive and HIV negative) (n = 200). Read More

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December 2018

Exposure to phthalates aggravates pulmonary function and airway inflammation in asthmatic children.

PLoS One 2018 17;13(12):e0208553. Epub 2018 Dec 17.

Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea.

Introduction: Studies on the associations between phthalate exposures and respiratory outcomes are limited. We investigated the association of phthalates exposure with pulmonary function and airway inflammation in asthmatic children.

Methods: Fifty-six children with asthma living in Seoul Metropolitan Area, Korea aged 6-16 years were enrolled. Read More

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December 2018

NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0007045. Epub 2018 Dec 17.

Department of Nutrition, University of California, Davis, California, United States of America.

Background: Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment. Metabolomics of cerebrospinal fluid (CSF) was explored as a method of differentiating among neurological diseases causing EM using a single CSF sample.

Methodology/principal Findings: 1H NMR metabolomics was applied to CSF samples from 27 patients with a laboratory-confirmed disease, including Lyme disease or West Nile Virus meningoencephalitis, multiple sclerosis, rabies, or Histoplasma meningitis, and 25 controls. Read More

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December 2018

Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0006975. Epub 2018 Dec 17.

Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, United States of America.

Background: Hyperendemic circulation of all four types of dengue virus (DENV-1-4) has expanded globally, fueling concern for increased incidence of severe dengue. While the majority of DENV infections are subclinical, epidemiologic studies suggest that type-cross-reactive immunity can influence disease outcome in subsequent infections. The mechanisms controlling these differential clinical outcomes remain poorly defined. Read More

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December 2018

PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease.

PLoS One 2018 17;13(12):e0208974. Epub 2018 Dec 17.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.

Background: Accurate classification of patients with inflammatory bowel disease into the subtypes ulcerative colitis (UC) and Crohn's disease (CD) is still a challenge, but important for therapy and prognosis.

Objectives: To evaluate the diagnostic utility of anti-neutrophil cytoplasmic antibodies specific for proteinase-3 (PR3-ANCA) for ulcerative colitis (UC) and the value of an antibody panel incorporating PR3-ANCA to differentiate between Crohn's disease (CD) and UC.

Study Design: In this cohort study, 122 pediatric and adolescent individuals were retrospectively included (61 IBD patients of two clinical centers, 61 non-IBD controls). Read More

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December 2018

Hippotherapy in Rehabilitation Care for Children With Neurological Impairments and Developmental Delays: A Case Series.

Pediatr Phys Ther 2019 Jan;31(1):E14-E21

Department of Developmental Rehabilitation (Ms Kraft) and Children's Minnesota Research Institute (Drs Finch and Barnes and Mss Nickel and Griffin), Children's Hospital and Clinics of Minnesota, Minneapolis, Minnesota; Hold Your Horses (Ms Weisberg), Maple Plain, Minnesota.

Purpose: This report assesses functional mobility in children with neurological impairments and documented gross motor delays, before and after receiving either hippotherapy or standard outpatient physical therapy (PT).

Summary Of Key Points: This is a case-series report using data previously collected for a discontinued randomized controlled trial, in which participants received hippotherapy or standard outpatient clinic PT for a 12-week treatment period. Results demonstrated both subjective and objective functional mobility improvements after treatment in participants receiving hippotherapy and standard outpatient PT, as determined by the Peabody Developmental Motor Scales-2, the Pediatric Evaluation of Disability Inventory, and the Goal Attainment Scaling. Read More

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January 2019

Standing Tall: Feasibility of a Modified Ride-On Car That Encourages Standing.

Pediatr Phys Ther 2019 Jan;31(1):E6-E13

Social Mobility Lab (Drs Logan and Catena and Mss Hospodar, Yohn, and Govindan), College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; Go Baby Go Lab (Ms Sabet), College of Health Sciences, Cleveland State University, Cleveland, Ohio; Pediatric Mobility Lab and Design Studio (Dr Galloway), Department of Physical Therapy and Biomechanics and Movement Sciences Program, University of Delaware, Newark, Delaware.

Purpose: The purpose of this study was to determine the feasibility of infants with Down syndrome to use a modified ride-on car with seated and standing modes.

Methods: Participants included 4 infants with Down syndrome. Families were asked to provide at least 8 minutes of modified ride-on car driving per day, at least 5 times per week throughout the 9-month intervention. Read More

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January 2019

Application of the Clinical Practice Guideline for Congenital Muscular Torticollis: A Case Report.

Pediatr Phys Ther 2019 Jan;31(1):E1-E5

Mary Free Bed Rehabilitation Hospital (Dr Huegel), Grand Rapids, Michigan; Department of Physical Therapy (Dr Kenyon), Grand Valley State University, Grand Rapids, Michigan.

Purpose: This case report illustrates application of the Clinical Practice Guideline for Congenital Muscular Torticollis in a pediatric outpatient facility.

Descriptions: The infant was a 2-month-old baby presenting with congenital muscular torticollis. Application of each of the 16 action statements outlined in the Clinical Practice Guideline is detailed as related to the case. Read More

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January 2019

Commentary on "Changes in Perceived Self-efficacy of Physical Therapist Students Following a Pediatric Experiential Learning Opportunity".

Pediatr Phys Ther 2019 Jan;31(1):121

University of Colorado Pediatric Residency Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado Physical Therapy Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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January 2019

Changes in Perceived Self-efficacy of Physical Therapist Students Following a Pediatric Experiential Learning Opportunity.

Pediatr Phys Ther 2019 Jan;31(1):115-120

University of Jamestown Physical Therapy Program, University of Jamestown, and Education Doctoral Program, North Dakota State University, Fargo, North Dakota.

Purpose: Physical therapists (PT) must be competent to treat patients across the lifespan, from pediatrics through geriatrics. Increasing the amount of experiential learning (EL) in pediatrics presents an opportunity for students to improve their self-efficacy in communication and patient handling. The purpose was to investigate changes in PT students' perceived self-efficacy in communication and patient handling following a structured and focused 8-week EL opportunity with a pediatric population. Read More

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January 2019

Commentary on "Moving Toward Excellence in Pediatric Physical Therapy Education: A Scoping Review".

Pediatr Phys Ther 2019 Jan;31(1):114

Department of Physical Therapy, Department of Developmental-Behavioral Pediatrics, University of South Alabama, Mobile, Alabama Children's Hospital of Alabama, Birmingham, Alabama.

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January 2019

Adapted Dance Improves Motor Abilities and Participation in Children With Down Syndrome: A Pilot Study.

Pediatr Phys Ther 2019 Jan;31(1):76-82

Division of Occupational Therapy and Physical Therapy (Ms McGuire and Drs Long and Bailes) and Division of Developmental and Behavioral Pediatrics (Dr Esbensen), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Purpose: This pilot study measured effects of an adapted dance program on motor abilities and participation in children with Down syndrome (DS) and explored caregivers' qualitative feedback regarding its benefits.

Methods: Children with DS participated in 20 weekly 1-hour adapted dance sessions. The Canadian Occupational Performance Measure (COPM) and Gross Motor Function Measure (GMFM) Dimensions D and E were administered before and after the program. Read More

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January 2019

Progression of Ankle Plantarflexion Contractures and Functional Decline in Duchenne Muscular Dystrophy: Implications for Physical Therapy Management.

Pediatr Phys Ther 2019 Jan;31(1):61-66

Department of Pediatrics (Drs Kiefer and Wong), University of Massachusetts Medical School, Worcester, Massachusetts; Division of Occupational Therapy and Physical Therapy (Drs Kiefer, Bonarrigo, Quatman-Yates, and Fowler) and Division of Neurology (Drs Kiefer, Bonarrigo, Fowler, Horn, and Wong), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics (Dr Horn), University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Physical Therapy (Dr Quatman-Yates), The Ohio State University, Columbus, Ohio.

Purpose: This study characterizes the progressive loss of ankle dorsiflexion range of motion in boys with Duchenne muscular dystrophy (DMD), the relationship to functional decline, and the implications for physical therapy management.

Methods: Longitudinal data for 332 boys with DMD were extracted from medical records and analyzed. Summary statistics for age, number of visits, ankle dorsiflexion measures, and North Star Ambulatory Assessment (NSAA) scores were computed. Read More

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January 2019

A novel preservation solution containing a JNK inhibitory peptide efficiently improves islet yield for porcine islet isolation.

Transplantation 2018 Dec 13. Epub 2018 Dec 13.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Background: For islet transplantation, pancreas preservation in UW solution is associated with disadvantages such as collagenase inhibition, resulting in poor islet yield and islets with poor viability. In this study, we evaluated a novel preservation solution, the extracellular-type c-Jun N-terminal kinase (JNK) inhibitor-containing (EJ) solution.

Methods: EJ solution has high sodium-low potassium composition with low viscosity compared to UW solution. Read More

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December 2018

Pediatric Advance Care Plan. When Cure Is Not an Option.

Crit Care Med 2019 Jan;47(1):140-141

Department of Anesthesia and Pediatrics, West Virginia University Children's Hospital, West Virginia University, Morgantown, WV Department of Anesthesia, West Virginia University, Morgantown, WV.

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January 2019

Weight status change from childhood to early adulthood and the risk of adult hypertension.

J Hypertens 2018 Dec 13. Epub 2018 Dec 13.

Department of Epidemiology.

Objective: Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from childhood to early adulthood and adult hypertension in the Chinese population. Read More

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December 2018

Characteristics of Emergency Department Presentations of Pediatric Poisoning Between 2011 and 2016: A Retrospective Observational Study in South Korea.

Pediatr Emerg Care 2018 Dec 14. Epub 2018 Dec 14.

From the Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea.

Objectives: Pediatric poisoning represents a major preventable cause of morbidity. The epidemiology of pediatric poisoning differs by country and region. This study aimed to characterize pediatric poisoning in South Korea over the last 6 years and to discuss current regulations related to the causative agents involved in pediatric poisoning. Read More

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December 2018

The Effect of a Primary Care Provider Incentive Program on Pediatric Emergency Medicine Visits.

Pediatr Emerg Care 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.

Objective: The aim of the study was to analyze the effect of a financial incentive program targeting primary care providers (PCPs) with the goal of decreasing emergency department (ED) utilization.

Methods: We performed a retrospective cohort analysis in a single health maintenance organization comparing ED visit/1000 member-months before and after the physician incentive program in 2009. We compared the median ED visit rate between physicians who did (PIP) and did not participate (non-PIP) from 2009 to 2012. Read More

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December 2018

Encouraging a Bare Minimum While Striving for the Gold Standard: A Response to the Updated WHO-WFSA Guidelines.

Anesth Analg 2019 Jan;128(1):e12-e13

Journalism, Specialist Anaesthetist, Department of Anaesthesia and Perioperative Medicine, The Alfred Hospital and Monash University, Melbourne, Australia Consultant Anesthesiologist, King Faisal Hospital and Program Director, College of Medicine and Health Sciences University of Rwanda Consultant Anesthesiologist, Addis Ababa University, Ethiopia Consultant Anesthesiologist, Maputo Pain Clinic, Mozambique Anesthesiologist, Dalhousie University, Halifax, Canada Managing Director, Diamedica, United Kingdom Specialist Anaesthetist, Hobart, Tasmania Professor Emeritus, Queen's University, Departments of Anesthesiology, Pediatrics and Physiology, Kingston, Ontario, Canada Professor, Departments of Anesthesiology and Surgery Division of Ambulatory Surgery, Director, Vanderbilt Anesthesia Global Health & Development, Director, Vanderbilt Global Anesthesia Fellowship Affiliate Faculty, Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine and Vanderbilt University Medical Center.

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January 2019

The Transcriptional Signature of a Runner's High.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

SUNY Upstate Medical University, Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology, Pediatrics, and Psychiatry & Behavioral Sciences, Syracuse NY.

Introduction: Endorphins, endocannabinoids, monoamines, and neurotrophins have all been implicated in the euphoric response to endurance running, known as a runner's high. The epi-transcriptional mechanisms regulating this effect have not been defined. Here, we investigate peripheral micro-ribonucleic acid (miRNA) changes unique to athletes experiencing post-run euphoria, yielding insights about gene networks that control a runner's high. Read More

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December 2018

Differences of Immune Reconstitution of Dendritic Cells in Pediatric GvHD Patients After Allogenic Stem Cell Transplantation.

J Pediatr Hematol Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Pediatric Hematology and Oncology, University Hospital Würzburg, Germany.

Background: Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for children with a variety of (non) malignant conditions. GvHD is a severe complication with high morbidity and mortality. The pathogenesis remains unclear. Read More

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November 2018

Intracranial Hemorrhage in Children With Inherited Bleeding Disorders: A Single Center Study in China.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Intracranial hemorrhage (ICH) is a life-threatening condition in children. Inherited bleeding disorders (IBD) have high risk of ICH.

Aim: This single center study aims to identify the incidence, risk factors, and neurological outcome of ICH in children who suffer from IBD. Read More

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December 2018

Causes of Hypochromic Microcytic Anemia in Children and Evaluation of Laboratory Parameters in the Differentiation.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Kanuni Sultan Suleyman Training and Research Hospital, Pediatric Hematology Oncology, Istanbul, Turkey.

Most common causes of microcytic anemia in children are iron deficiency anemia (IDA) and thalassemia. Differentiation of these and detection of coexistence is essential for genetic counseling and to set a treatment plan. Aim is to characterize the frequency of IDA and thalassemia trait (TT) in children presenting with hypochromic, microcytic anemia and to define the significance of blood count parameters in differential diagnosis. Read More

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December 2018
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