Search Our Scientific Publications & Authors

J Family Med Prim Care 2021 Jun 2;10(6):2358-2362. Epub 2021 Jul 2.

Mansoura University, King Khalid University, Abha, Saudi Arabia.

Background: Paediatric rhinosinusitis is mostly different than that in adults. More frequently, children presented with cough, bad breath, crankiness, low energy, and swelling around the eyes, besides a thick yellow-green nasal or post-nasal discharge. About 5- 13% of childhood viral upper respiratory tract infections may advance to acute rhinosinusitis, with some of them developing a chronic condition. Read More

Eur Arch Otorhinolaryngol 2021 Jul 22. Epub 2021 Jul 22.

Department of Otolaryngology Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland.

Purpose: Chronic rhinosinusitis (CRS) is observed in almost 100% of patients with cystic fibrosis (CF). CF-related CRS treatment is extremely challenging because of the underlying genetic defect leading to its development. CRS in CF is often refractory to standard therapy, while recurrences after surgical treatment are inevitable in the majority of patients. Read More

Pathogens 2021 Jun 10;10(6). Epub 2021 Jun 10.

Pediatric Infectious Diseases, University Children's Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Background: () is known to cause dental, periodontal or sinus infections. To date, the pathogen has only been described in a small number of cases with a severe infection.

Case Report: We describe the clinical case of a 13-year-old, obese female patient that presented with acute respiratory failure and sepsis. Read More

Transplant Cell Ther 2021 Jun 19. Epub 2021 Jun 19.

Hematopoietic Stem Cell Transplantation Unit, Princess Máxima Center for Pediatric Oncology, Wilhelmina Children's Hospital, UMC Utrecht, University Utrecht, Utrecht, The Netherlands.

Data on the outcome of allogenic hematopoietic stem cell transplantation (HSCT) in pediatric patients with a history of invasive fungal infection (IFI) are limited. The aim of this study was to report on the feasibility and outcome of allogenic HSCT in pediatric patients with an active or recently diagnosed IFI. In this retrospective, single-center study, 317 children underwent an allogenic HSCT (January 2012 to June 2020), of whom 23 had an active or recent (<6 months before transplantation) diagnosis of a probable or proven IFI before HSCT. Read More

Arerugi 2021 ;70(4):310-314

Department of Pediatrics, Saitama Medical University Hospital.

A 12-year-old boy visited our hospital with complaints of chronic cough and dyspnea. Chest X-ray and CT revealed diffuse granular shadow in the bilateral lung fields and "Tree-in-bud appearance" in the peripheral airways, respectively. Sinusitis was present, and restrictive disorder was predominantly found in pulmonary function. Read More

Turk Arch Pediatr 2021 1;56(3):236-244. Epub 2021 May 1.

Department of Child Health and Diseases, Department of Child Neurology, Ege University School of Medicine, İzmir, Turkey.

Objective: The study aimed to evaluate the patients with a diagnosis of cerebral sinovenous thrombosis in terms of clinical findings, etiology and underlying risk factors, imaging findings, treatment, and prognosis in the long term.

Materials And Methods: Medical records of 19 patients whose ages ranged between 0 days and 17 years with clinical and radiological cerebral sinovenous thrombosis in Ege University Department of Child Neurology were retrospectively evaluated.

Results: Nine of nineteen cases were female (47. Read More

J Cyst Fibros 2021 May 22. Epub 2021 May 22.

Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin, Berlin, Germany.

Background: Epidemiology and potential risk factors for cystic fibrosis arthropathy (CFA) were studied in a relevant cystic fibrosis (CF) patient cohort.

Methods: Cohort study of patients included in the German CF registry in 2016-2017. Descriptive analysis, exploratory tests and multivariable logistic regression were used to assess prevalence of CFA and associated potential risk factors for adult patients with/without chronic Pseudomonas aeruginosa infection. Read More

Am J Case Rep 2021 May 25;22:e929892. Epub 2021 May 25.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Nebraska Medical Center, Omaha, NE, USA.

BACKGROUND Anti-TNF-alpha therapies were the first class of biologics to be used in treatment of moderate to severe IBD. Immunosuppression status that develops from using anti-TNF-a therapies increases the risk of serious and opportunistic infections. We present here a rare case of serious infection that developed in an IBD patient while on anti-TNF therapy. Read More

Can J Respir Ther 2021 21;57:44-48. Epub 2021 Apr 21.

Pediatric Intensive Care Unit, Children's Damascus University Hospital, Damascus, Syria.

Kartagener syndrome is a rare, autosomal recessive genetic disorder that causes defects in the action of ciliary movement, comprises of triad situs inversus, chronic sinusitis, and bronchiectasis. We present the case of a 3-year-old boy with repeated respiratory infections and pneumonic infections presenting with acute respiratory failure. He was diagnosed with Kartagener syndrome based on his clinical presentation and imaging features. Read More

Rhinology 2021 Jun;59(3):319-327

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russia; K.A. Raukhfus Childrens City Multidisciplinary Clinical Center for High Medical Technologies, St. Petersburg, Russia.

Background: The objective of the study is evaluation of ciliary function and mucosal cytology after endoscopic sinus surgery in children with chronic rhinosinusitis (CRS).

Methodology: A total of 132 children with CRS who underwent endoscopic sinus surgery, as well as 15 healthy controls were involved in the study. In this follow-up study patients were examined preoperatively, as well as 3, 6, 9, and 12 months after endoscopic sinus surgery. Read More

Front Neurol 2021 8;12:606617. Epub 2021 Apr 8.

French Center for Pediatric Stroke, Pediatric Neurology Department, APHP University Hospital Necker-Enfants Malades, Paris, France.

Neurologic manifestations associated with Covid-19 are increasingly reported, especially stroke and acute cerebrovascular events. Beyond cardiovascular risk factors associated with age, some young adults without medical or cardiovascular history had stroke as a presenting feature of Covid-19. Suggested stroke mechanisms in this setting are inflammatory storm, subsequent hypercoagulability, and vasculitis. Read More

Am J Otolaryngol 2021 Mar 31;42(5):103016. Epub 2021 Mar 31.

Department of Otolaryngology, Division of Pediatric Otolaryngology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA, United States of America.

Purpose: Pediatric cystic fibrosis (CF) patients have a variable onset, severity, and progression of sinonasal disease. The objective of this study was to identify genotypic and phenotypic factors associated with CF that are predictive of sinonasal disease, recurrent nasal polyposis, and failure to respond to standard treatment.

Methods: A retrospective case series was conducted of 30 pediatric patients with CF chronic rhinosinusitis with and without polyps. Read More

Int J Pediatr Otorhinolaryngol 2021 May 28;144:110693. Epub 2021 Mar 28.

Division of Pediatric Otolaryngology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Introduction: Subperiosteal orbital abscess (SPOA) is a serious suppurative complication of pediatric sinusitis. The objective of this study is to stratify patient selection into those best treated medically versus surgically based on clinical outcomes.

Methods: This is a retrospective review of patients diagnosed with SPOA complicating sinusitis treated at a tertiary care pediatric hospital from 2002 through 2016. Read More

JAMA Netw Open 2021 03 1;4(3):e212713. Epub 2021 Mar 1.

Department of Internal Medicine, Albany Medical College, Albany, New York.

Importance: Acute bacterial sinusitis is common, but currently recommended antibiotic treatment provides minimal benefit.

Objective: To confirm the previous finding that high-dose amoxicillin plus clavulanate (with double the amount of amoxicillin) may be superior to standard-dose amoxicillin plus clavulanate in adults.

Design, Setting, And Participants: This double-blind, comparative-effectiveness randomized clinical trial was conducted from February 26, 2018, through May 10, 2020, at the academic primary care internal medicine and pediatrics practice of Albany Medical Center, located in Cohoes, New York. Read More

Vestn Otorinolaringol 2021 ;86(1):68-71

Central State Medical Academy, Moscow, Russia.

Isolated sphenoid osteomas are very rare even in adults. There are extremely few publications on pediatric cases of sphenoid osteomas. This paper presents a case of isolated sphenoid osteoma combined with suppurative sphenoiditis in a 15-year-old patient. Read More

Respir Investig 2021 May 26;59(3):270-290. Epub 2021 Feb 26.

Tokyo Women's Medical University, Japan.

Cough and sputum are common complaints at outpatient visits. In this digest version, we provide a general overview of these two symptoms and discuss the management of acute (up to three weeks) and prolonged/chronic cough (longer than three weeks). Flowcharts are provided, along with a step-by-step explanation of their diagnosis and management. Read More

Int J Pediatr Otorhinolaryngol 2021 Apr 30;143:110638. Epub 2021 Jan 30.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Objectives: To determine whether current guidelines emphasizing antibiotic stewardship in pediatrics have been associated with reduced prevalence of antibiotic allergies in children severely affected by otitis media undergoing bilateral myringotomy with tympanostomy tube insertion (BMT) or by recurrent sinusitis or adenotonsillitis undergoing adenoidectomy with or without tonsillectomy.

Methods: Case series of consecutive patients undergoing BMT or adenoidectomy with/without tonsillectomy for recurrent acute otitis media, recurrent sinusitis, or recurrent tonsillitis during November 2008 or November 2017 at a tertiary care children's hospital. Children with primarily obstructive indications for surgery, with prior tube placement or adenoidectomy, or with surgery by an outside provider were excluded. Read More

BMC Pulm Med 2021 Feb 8;21(1):53. Epub 2021 Feb 8.

Section of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.

Background: Gastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated.

Aims: To evaluate the strength of the association between gastritis/GERD and non-allergic rhinitis (NAR)/allergic rhinitis (AR)/sinusitis.

Methods: We investigated 2887 subjects aged 20-84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study between 2008 and 2014. Read More

Ophthalmol Ther 2021 Jun 4;10(2):261-271. Epub 2021 Feb 4.

Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

Introduction: Our objective was to assess the utility of using lesion-mapping software to calculate precise orbital volumes to predict patients who would benefit from early surgical intervention.

Methods: We retrospectively reviewed patients diagnosed with subperiosteal orbital abscess (SPOA) secondary to sinusitis at a tertiary pediatric hospital from 2005 to 2016. Diagnoses were confirmed by CT scans. Read More

Iran J Allergy Asthma Immunol 2020 Aug 25;19(4):452-455. Epub 2020 Aug 25.

Department of Immunology and Allergy, Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Brain tumors are the rarest cause of cerebrospinal fluid rhinorrhea. Non-traumatic cerebrospinal fluid rhinorrhea is also a relatively rare condition. It may be misdiagnosed as allergic rhinitis or chronic sinusitis and lead to unsuitable treatment. Read More

Ann Otol Rhinol Laryngol 2021 Aug 13;130(8):923-928. Epub 2021 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Introduction: Frontal sinusitis in the pediatric population is a disease that has not been thoroughly studied or characterized. The goals of this study are to characterize the clinical presentation, radiologic variables, treatment modalities, complications, and prognosis associated with acute and chronic frontal sinus disease in the pediatric population.

Methods: IRB-approved retrospective cohort study of pediatric patients who were diagnosed with acute (AFS) or chronic frontal sinusitis (CFS) and underwent frontal sinus surgery at a tertiary level Children's Hospital from 2006 to 2016. Read More

Brain Sci 2021 Jan 9;11(1). Epub 2021 Jan 9.

Department of Clinical and Molecular Medicine, Sapienza University, 00189 Rome, Italy.

'Sinus headache and/or facial pain' (SH) is a common complaint encountered by otorhinolaryngologists, neurologists and general practitioners. However, several studies suggested that the majority of those cases may be attributed to primary headaches (i.e. Read More

Auris Nasus Larynx 2021 Jan 6. Epub 2021 Jan 6.

Children's Mercy Hospital, Kansas City, Missouri, Department of Ear, Nose, and Throat USA.

This case report describes a child who developed Pott's puffy tumor and was treated at the Children's Mercy Hospital in Kansas City. In addition to a discussion of a case, a review of the literature was completed on this topic describing the typical embryology and development of the frontal sinus, and the epidemiology, diagnosis, and treatment of Pott's puffy tumor. The patient was a 23-month-old boy who developed Pott's puffy tumor after recovery from influenza. Read More

Orbit 2021 Jan 3:1-5. Epub 2021 Jan 3.

Albany Medical College, USA.

: While sinusitis carries a seasonal variation, the temporal features of sinusitis-related orbital cellulitis (SRC) are unclear. This study analyzes the incidence, seasonality, management, and outcomes of SRC in northeastern New York.: A retrospective review of 79 patients was performed from January 2008 - December 2018. Read More

Orbit 2021 Jan 1:1-7. Epub 2021 Jan 1.

Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.

: To evaluate the predominant pathogens and clinical course in pediatric patients with orbital cellulitis (OC) complicated by subperiosteal abscess (SPA).: This is a single-center retrospective chart review evaluating pediatric patients with OC complicated by SPA treated at a tertiary care center in the Pacific Northwest. Data were analyzed for characteristics, rates of infection, and antibiotic resistance of the predominant pathogens in pediatric patients. Read More

Int J Pediatr Otorhinolaryngol 2021 Jan 3;140:110542. Epub 2020 Dec 3.

Augusta University, Department of Otolaryngology- Head and Neck Surgery, Augusta, Georgia, USA. Electronic address:

Background: There remains variation in management of orbital complications of acute bacterial rhinosinusitis (ABRS); specifically, those subperiosteal abscesses that present without immediate surgical indication. Recent systematic reviews on management and proposed treatment algorithms are helpful but do not consider the financial implications for healthcare systems and patients.

Methods: A retrospective chart review of pediatric patients from a tertiary care children's hospital between 2002 and 2020 was performed, identifying patients via ICD coding corresponding to acute bacterial sinusitis and orbital involvement classified as Chandler 3 confirmed by contrasted computed tomography (CT). Read More

Int J Pediatr Otorhinolaryngol 2021 Jan 3;140:110548. Epub 2020 Dec 3.

Department of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Objective: Non-surgical management of chronic rhinosinusitis (CRS) in children with cystic fibrosis (CF) has been increasing over the last decade. This study examines inpatient children with pulmonary exacerbation of CF who were also diagnosed with CRS and underwent endoscopic sinus surgery (ESS).

Study Design: We used the 2003 to 2016 Kids Inpatient Database to perform a cross-sectional analysis of inpatients (ages 0-21 years) diagnosed with CF and CRS in the United States from 2003 to 2016. Read More

PLoS One 2020 2;15(12):e0242770. Epub 2020 Dec 2.

Department of Otorhinolaryngology-Head and Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-Si, Korea.

We hypothesized that differences in the microbiome could be a cause of the substantial differences in the symptoms of and treatment options for adult and pediatric patients with chronic rhinosinusitis (CRS). First, we characterized the differences in the nasal microbiomes of pediatric and adult CRS patients. Swabs were obtained from 19 patients with chronic rhinosinusitis (9 children and 10 adults). Read More

Indian J Otolaryngol Head Neck Surg 2020 Nov 11:1-4. Epub 2020 Nov 11.

Department of Otorhinolaryngology and Head and Neck Department, Ram Lal Eye and ENT Hospital, Government Medical College, Majitha Road, Amritsar, Punjab 143001 India.

In this modern era, when access to healthcare services is improved, and awareness among the general population is enhanced, the presentation of mere septal abscess of the nose as a fatal complication is less common. Due to various lockdown restrictions in the COVID-19 scenario and fear to contract an infection, patients are presenting late to the health care setting for proper management. We treated an 11-year old child of complicated nasal septal abscess who responded well to aspiration of pus and medical treatment. Read More

Am J Otolaryngol 2020 Nov - Dec;41(6):102746. Epub 2020 Sep 23.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ, USA; Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address:

With the ongoing development of the COVID-19 pandemic, research continues to emerge regarding the pathophysiology, characteristics, and treatment considerations for patients with COVID-19. No reports have highlighted the specific challenges posed in the management of pediatric patients with COVID-19 who present with complicated rhinosinusitis. In this report, we discuss our preoperative, intraoperative, and postoperative multidisciplinary treatment strategy for these cases and provide two examples of complicated rhinosinusitis cases in COVID-19 patients, treated with two different approaches. Read More