11,687 results match your criteria Pediatric Research[Journal]


The definition of a hemodynamically significant ductus arteriosus.

Pediatr Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Neonatology, Beth Israel Deaconess Medical Center and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41390-019-0342-7DOI Listing
February 2019

Maternal preeclampsia and respiratory outcomes in extremely premature infants.

Pediatr Res 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive.

Objective: To determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0336-5DOI Listing
February 2019
1 Read

Correction: Thrombospondin-targeting TAX2 peptide impairs tumor growth in preclinical mouse models of childhood neuroblastoma.

Pediatr Res 2019 Feb 14. Epub 2019 Feb 14.

Universite de Reims Champagne-Ardenne, UFR Sciences Exactes et Naturelles, Reims, France.

The authors "Revital Rattenbach", "ltschak Lamensdorf", and "Celine Martin" were not included in the author list of this published article however should be considered to be authors since they contributed substantially to the work. The updated author list of this article can be found in the associated correction. Read More

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http://dx.doi.org/10.1038/s41390-019-0329-4DOI Listing
February 2019

Family reflections: prematurity.

Authors:
Helen Ward

Pediatr Res 2019 Feb 14. Epub 2019 Feb 14.

Bliss, Maya House, 134-138 Borough High Street, London, SE1 1LB, UK.

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http://dx.doi.org/10.1038/s41390-019-0339-2DOI Listing
February 2019

Maternal hypertension and survival in singletons and twins born at 23-29 weeks: not just one answer….

Pediatr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, QC, Canada.

Objective: To describe the association between maternal hypertension (chronic and gestational, MH) and mortality in very preterm singletons and twins, focusing on how estimates depend on gestational age (GA) and size at birth.

Methods: We estimated relative risks of in-hospital death in 12,320 singletons (MH: 22.4%) and 4381 twins (MH: 10. Read More

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http://www.nature.com/articles/s41390-019-0337-4
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http://dx.doi.org/10.1038/s41390-019-0337-4DOI Listing
February 2019
1 Read

MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia.

Pediatr Res 2019 Feb 13. Epub 2019 Feb 13.

Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, and Lilling Family Neonatal Research Laboratory, Feinstein Institute for Medical Research, Manhasset, NY, USA.

Background: Congenital diaphragmatic hernia (CDH) is a complex birth anomaly with significant mortality and morbidity. Lung hypoplasia and persistent pulmonary hypertension (PPHN) limit survival in CDH. Macrophage migration inhibitory factor (MIF), a key regulator of innate immunity, is involved in hypoxia-induced vascular remodeling and PPHN. Read More

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http://www.nature.com/articles/s41390-019-0335-6
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http://dx.doi.org/10.1038/s41390-019-0335-6DOI Listing
February 2019
4 Reads

Diffuse optical tomography for the detection of perinatal stroke at the cot side: a pilot study.

Pediatr Res 2019 Feb 13. Epub 2019 Feb 13.

neoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Perinatal stroke is a potentially debilitating injury, often under-diagnosed in the neonatal period. We conducted a pilot study investigating the role of the portable, non-invasive brain monitoring technique, diffuse optical tomography (DOT), as an early detection tool for infants with perinatal stroke.

Methods: Four stroke-affected infants were scanned with a DOT system within the first 3 days of life and compared to four healthy control subjects. Read More

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http://dx.doi.org/10.1038/s41390-018-0263-xDOI Listing
February 2019

The mucosal-luminal interface: an ideal sample to study the mucosa-associated microbiota and the intestinal microbial biogeography.

Pediatr Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.

Background: Alterations in gastrointestinal microbial communities have been linked to human disease. Most studies use fecal samples as a proxy for the intestinal microbiota; however, the fecal microbiome is not fully representative of the mucosa-associated microbiota at the site of disease. While mucosal biopsies can be used instead, they often contain a high proportion of host DNA that can confound 16S ribosomal RNA (rRNA) gene sequencing studies. Read More

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http://dx.doi.org/10.1038/s41390-019-0326-7DOI Listing
February 2019

Gender bias at Pediatric Research?

Pediatr Res 2018 Dec 9. Epub 2018 Dec 9.

Department of Paediatrics, Trinity College, University of Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1038/s41390-018-0246-yDOI Listing
December 2018

Ventricular remodeling in preterm infants: computational cardiac magnetic resonance atlasing shows significant early remodeling of the left ventricle.

Pediatr Res 2018 Nov 19. Epub 2018 Nov 19.

Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Premature birth is associated with ventricular remodeling, early heart failure, and altered left ventricular (LV) response to physiological stress. Using computational cardiac magnetic resonance (CMR) imaging, we aimed to quantify preterm ventricular remodeling in the neonatal period, and explore contributory clinical factors.

Methods: Seventy-three CMR scans (34 preterm infants, 10 term controls) were performed to assess in-utero development and preterm ex-utero growth. Read More

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http://dx.doi.org/10.1038/s41390-018-0171-0DOI Listing
November 2018

Dr. Giulio J. D'Angio (1922-2018).

Pediatr Res 2019 Feb 7. Epub 2019 Feb 7.

Giulio D'Angio Professor of Pediatric Oncology Perelman School of Medicine, Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1038/s41390-019-0328-5DOI Listing
February 2019

Heart rate variability alterations in infants with spontaneous hypertonia.

Pediatr Res 2019 Jan 30. Epub 2019 Jan 30.

Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Hypertonia is characterized by increased resting muscle tone. Previous studies have shown that adult patients with hypertonia displayed autonomic imbalance. However, cardiac sympatho-vagal control in infants with hypertonia have not been explored. Read More

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http://dx.doi.org/10.1038/s41390-019-0318-7DOI Listing
January 2019

May ECI biocommentary.

Authors:
Deepak Jain

Pediatr Res 2019 Feb 12. Epub 2019 Feb 12.

Miller School of Medicine - Pediatrics, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41390-019-0333-8DOI Listing
February 2019

Urinary acute kidney injury biomarkers in very low-birth-weight infants on indomethacin for patent ductus arteriosus.

Pediatr Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.

Background: Serum creatinine (SCr)- or urine output-based definitions of acute kidney injury (AKI) have important limitations in neonates. This study evaluates the diagnostic value of urinary biomarkers in very low-birth-weight (VLBW) infants receiving indomethacin for closure of a patent ductus arteriosus (PDA).

Methods: Prospective cohort study in 14 indomethacin-treated VLBW infants and 18 VLBW infants without indomethacin as controls. Read More

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http://dx.doi.org/10.1038/s41390-019-0332-9DOI Listing
February 2019
1 Read
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The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months.

Pediatr Res 2019 Feb 11. Epub 2019 Feb 11.

The Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland.

Background: Insulin-like growth factor (IGF)-I and -II play an important role in prenatal growth. During the first 2 months from birth, body fat doubles, and rapid weight gain during this time increases future risk of cardiometabolic disease.

Objective: To determine whether IGF measurements at birth associate with body composition and the trajectory of its changes in the first 2 months. Read More

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http://dx.doi.org/10.1038/s41390-019-0331-xDOI Listing
February 2019

Fetal inflammation is associated with persistent systemic and hippocampal inflammation and dysregulation of hippocampal glutamatergic homeostasis.

Pediatr Res 2019 Feb 11. Epub 2019 Feb 11.

Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Background: Inflammation is a major cause of preterm birth and often results in a fetal inflammatory response syndrome (FIRS). Preterm infants with FIRS have a higher childhood incidence of neurodevelopmental disability than preterm infants without FIRS. The mechanisms connecting FIRS to neurodevelopmental disability in formerly preterm infants are not fully understood, but the effect on premature gray matter may have an important role. Read More

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http://dx.doi.org/10.1038/s41390-019-0330-yDOI Listing
February 2019

Evaluating anti-epileptic drugs in the era of therapeutic hypothermia.

Pediatr Res 2019 Jan 30. Epub 2019 Jan 30.

The Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1038/s41390-019-0319-6DOI Listing
January 2019
1 Read

Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion.

Pediatr Res 2019 Jan 29. Epub 2019 Jan 29.

Department of Haematology, University of Cambridge, Cambridge, Cambridgeshire, UK.

Background: Neonatal haemorrhaging is often co-observed with thrombocytopenia; however, no evidence of a causal relationship with low platelet count has been reported. Regardless, the administration of a platelet transfusion is often based upon this parameter. Accurate measurement of platelet function in small volumes of adult blood samples by flow cytometry is well established and we propose that the use of the same technology could provide complementary information to guide the administration of platelet transfusions in premature neonates. Read More

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http://dx.doi.org/10.1038/s41390-019-0316-9DOI Listing
January 2019

Postnatal outcomes in lambs exposed antenatally and acutely postnatally to fluoxetine.

Pediatr Res 2019 Feb 9. Epub 2019 Feb 9.

Department of Obstetrics and Gynecology, Faculty of Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

Background: Approximately 1/3 of newborns exposed antenatally to selective serotonin reuptake inhibitors (SSRIs) exhibit poor neonatal adaptation. Although several potential mechanisms have been proposed, the actual mechanism has not been elucidated.

Methods: We investigated outcomes in neonatal lambs exposed prenatally or postnatally to fluoxetine (FX). Read More

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http://www.nature.com/articles/s41390-019-0309-8
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http://dx.doi.org/10.1038/s41390-019-0309-8DOI Listing
February 2019
1 Read

Correction: Sex-specific alterations in preterm brain.

Pediatr Res 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.

In the original article, the legend within Fig. 3 incorrectly read as '*p < 0.10, **p < 0. Read More

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http://dx.doi.org/10.1038/s41390-019-0323-xDOI Listing
February 2019

Prolonged duration of early antibiotic therapy in extremely premature infants.

Pediatr Res 2019 Jan 22. Epub 2019 Jan 22.

Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

Background: Prolonged early antibiotics in extremely premature infants may have negative effects. We aimed to assess prevalence and outcomes of provision of prolonged early antibiotics to extremely premature infants in the absence of culture-confirmed infection or NEC.

Methods: Cohort study of infants from 13 centers born without a major birth defect from 2008-2014 who were 401-1000 grams birth weight, 22-28 weeks gestation, and survived ≥5 days without culture-confirmed infection, NEC, or spontaneous intestinal perforation. Read More

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http://dx.doi.org/10.1038/s41390-019-0300-4DOI Listing
January 2019

Correction: Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia.

Pediatr Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

In the original version of this article, the Supplementary Information file contained incorrect reference numbers. 'Supplemental Table S1' has now been replaced with the corrected version, in which the correct reference numbers are cited. The authors would like to apologise for this error. Read More

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http://dx.doi.org/10.1038/s41390-019-0314-yDOI Listing
February 2019

Pre-Vent: the prematurity-related ventilatory control study.

Pediatr Res 2019 Feb 1. Epub 2019 Feb 1.

Division of Cardiovascular Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.

Background: The increasing incidence of bronchopulmonary dysplasia in premature babies may be due in part to immature ventilatory control, contributing to hypoxemia. The latter responds to ventilation and/or oxygen therapy, treatments associated with adverse sequelae. This is an overview of the Prematurity-Related Ventilatory Control Study which aims to analyze the under-utilized cardiorespiratory continuous waveform monitoring data to delineate mechanisms of immature ventilatory control in preterm infants and identify predictive markers. Read More

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http://dx.doi.org/10.1038/s41390-019-0317-8DOI Listing
February 2019
2 Reads

Should therapeutic hypothermia be offered to babies with mild neonatal encephalopathy in the first 6 h after birth?

Pediatr Res 2019 Jan 16. Epub 2019 Jan 16.

Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand.

Infants with moderate to severe neonatal encephalopathy (NE) benefit significantly from therapeutic hypothermia, with reduced risk of death or disability. However, the need for therapeutic hypothermia for infants with milder NE remains unclear. It has been suggested that these infants should not be offered therapeutic hypothermia as they may not be at risk for adverse neurodevelopmental outcome and that the balance of risk against potential benefit is unknown. Read More

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http://www.nature.com/articles/s41390-019-0291-1
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http://dx.doi.org/10.1038/s41390-019-0291-1DOI Listing
January 2019
5 Reads

Baroreceptor activity and sensitivity: normal values in children and young adults using the head up tilt test.

Pediatr Res 2019 Feb 6. Epub 2019 Feb 6.

Division of Pediatric Cardiology, Department of Pediatrics, McGovern Medical School The University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Baroreceptor function in children and adolescents has not been well studied in the current literature, with a lack of agreed upon normal values. The authors hypothesize that there is a significant increase in the baroreceptor activity with a decrease in the sensitivity during the upright phase in comparison to the supine phases of the head upright tilt test (HUTT) protocol.

Methods: Baroreceptor evaluation was performed using the sequence method in 49 subjects ages 8-21 years, during the 3 phases of HUTT: supine, head up, and post-tilt supine positions. Read More

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http://dx.doi.org/10.1038/s41390-019-0327-6DOI Listing
February 2019

Kawasaki disease OX40-OX40L axis acts as an upstream regulator of NFAT signaling pathway.

Pediatr Res 2019 Jan 25. Epub 2019 Jan 25.

Cardiology Department, Children's Hospital of Soochow University, 215025, Suzhou, Jiangsu Province, China.

Background: We investigated a costimulatory molecule OX40-OX40L acting as an upstream regulator to regulate the nuclear factor of activated T cell (NFAT) in the acute phase of Kawasaki disease (KD).

Methods: One hundred and one samples were collected and divided into six groups: coronary artery lesion (KD-CAL) before intravenous immunoglobulin (IVIG), KD-CAL after IVIG, KD without CAL (KD-nCAL) before IVIG, KD-nCAL after IVIG, fever of unknown (Fou), and Healthy. In vitro OX40-stimulating and OX40L-inhibiting tests were conducted in Healthy and KD groups, respectively. Read More

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http://dx.doi.org/10.1038/s41390-019-0312-0DOI Listing
January 2019
1 Read

Body fat indicators perform better than body mass index in identifying abnormal lipid profiles in boys but not in girls.

Pediatr Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Epidemiology, Capital Institute of Pediatrics; Graduate School of Peking Union Medical College, Beijing, China.

Background: BMI as a body weight indicator, may inadequately represent the biological effect of body fat on lipid profiles. This study aims to assess whether body fat indicators were superior to BMI for recognizing children with dyslipidemia.

Methods: A nationwide cross-sectional study involving 8944 pediatric participants aged 6-18 years. Read More

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http://dx.doi.org/10.1038/s41390-019-0287-xDOI Listing
January 2019

IGF-1 alleviates serum IgG-induced neuronal cytolysis through PI3K signaling in children with opsoclonus-myoclonus syndrome and neuroblastoma.

Pediatr Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Background: Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder, usually accompanied by neuroblastoma (NB). There is no targeted treatment and animal model of OMS. We aimed to investigate whether insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K) signaling alleviates neuronal cytolysis in pediatric OMS. Read More

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http://dx.doi.org/10.1038/s41390-018-0251-1DOI Listing
December 2018
1 Read

Vitamin D binding protein polymorphisms significantly impact vitamin D status in children.

Pediatr Res 2019 Feb 2. Epub 2019 Feb 2.

Department of Pediatrics/Division of Neonatology, Medical University of South Carolina, Charleston, SC, USA.

Background: Polymorphic alleles of the vitamin D (vitD)-binding protein (VDBP) gene are associated with discriminatory differences in circulating concentrations of 25-hydroxyvitamin D (25-D), the indicator of vitD status (sufficiency defined by the Endocrine Society as ≥75 nmol/L). Within a diverse group of children, we hypothesized that reaching recommended daily allowance (RDA) of vitD intake would have differential impact on vitD status depending on VDBP variability.

Methods: VDBP alleles (Gc1S, Gc1F, Gc2) in 123 children (1-4 annual visits/child; ages 1-8 years) were compared for relationships with serum 25-D concentrations and daily vitD intake. Read More

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http://dx.doi.org/10.1038/s41390-019-0322-yDOI Listing
February 2019

The effect of unilateral stroke on autonomic function in the term newborn.

Pediatr Res 2019 Feb 2. Epub 2019 Feb 2.

Fetal Medicine Institute, Children's National Health System, 111 Michigan Avenue NW, Washington, DC, 20010, USA.

Background: The mature cerebral cortex has a topographically organized influence on reflex autonomic centers of the brainstem and diencephalon and sympathetic activation coming primarily from the right hemisphere and parasympathetic activation from the left. In the term newborn, the maturational status of this central autonomic system remains poorly understood.

Methods: Sixteen term newborns admitted to Children's National with unilateral middle cerebral artery (MCA) strokes (n = 8 left, n = 8 right) had archived continuous electrocardiograph (EKG) signals available. Read More

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http://www.nature.com/articles/s41390-019-0320-0
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http://dx.doi.org/10.1038/s41390-019-0320-0DOI Listing
February 2019
1 Read

Mutational spectrum and novel candidate genes in Chinese children with sporadic steroid-resistant nephrotic syndrome.

Pediatr Res 2019 Feb 2. Epub 2019 Feb 2.

Molecular Immunology Laboratory, Capital Institute of Pediatrics, YaBao Road 2, 100020, Beijing, China.

Background: Approximately 10-20% of children with idiopathic nephrotic syndrome (NS) fail to respond to steroid therapy. NS is divided into steroid-sensitive NS (SSNS) and steroid-resistant NS (SRNS). Over 45 recessive and dominant genes have been found to be associated with SRNS and/or focal segmental glomerulosclerosis (FSGS). Read More

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http://dx.doi.org/10.1038/s41390-019-0321-zDOI Listing
February 2019
1 Read

Correction: Policy threats to maternal and child nutrition: putting the unborn child at a lifelong disadvantage.

Pediatr Res 2019 Feb 1. Epub 2019 Feb 1.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, USA.

Following publication of this article the authors noticed that affiliations were incorrectly assigned. The original article has now been updated so that the author "Joyce R. Javier" is associated with the "Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Department of Pediatrics, Division of General Pediatrics, Los Angeles, CA, USA", and the author "Vivek Balasubramaniam" is associated with the "Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, USA". Read More

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http://dx.doi.org/10.1038/s41390-019-0315-xDOI Listing
February 2019

The effect of light wavelength on in vitro bilirubin photodegradation and photoisomer production.

Pediatr Res 2019 Jan 26. Epub 2019 Jan 26.

Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Room S214, Stanford, CA, 94305, USA.

Background: The action spectrum for bilirubin photodegradation has been intensively studied. However, questions still remain regarding which light wavelength most efficiently photodegrades bilirubin. In this study, we determined the in vitro effects of different irradiation wavelength ranges on bilirubin photodegradation. Read More

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http://www.nature.com/articles/s41390-019-0310-2
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http://dx.doi.org/10.1038/s41390-019-0310-2DOI Listing
January 2019
3 Reads

Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity.

Pediatr Res 2019 Jan 23. Epub 2019 Jan 23.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161, Rome, Italy.

Objectives: To comprehensively explore metabolic and genetic contributors to liver fat accumulation in overweight/obese children.

Methods: Two hundred thirty Italian children with obesity were investigated for metabolic parameters and genotyped for PNPLA3, TM6SF2, GCKR, and MBOAT7 gene variants. Percentage hepatic fat content (HFF%) was measured by nuclear magnetic resonance. Read More

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http://dx.doi.org/10.1038/s41390-019-0303-1DOI Listing
January 2019

Accuracy of preterm infant weight gain velocity calculations vary depending on method used and infant age at time of measurement.

Pediatr Res 2019 Jan 25. Epub 2019 Jan 25.

CHU de Liege, CHR de la Citadelle, University of Liege, Liege, Belgium.

Background: We examined preterm infants' weight gain velocity (WGV) to determine how much calculation methods influences actual WGV during the first 28 days of life.

Methods: WGV methods (Average 2-point, Exponential 2-point, Early 1-point, and Daily) were calculated weekly and for various start times (birth, nadir, regain, day 3 and day 7) to 28 days of age for 103 preterm < 1500 gram infants, with daily weights.

Results: Range of WGV estimates decreased 10-22 g/kg/day to 15. Read More

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http://dx.doi.org/10.1038/s41390-019-0313-zDOI Listing
January 2019

Maternal obesity and gestational diabetes mellitus affect body composition through infancy: the PONCH study.

Pediatr Res 2019 Feb 10;85(3):369-377. Epub 2018 Dec 10.

Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: To determine how maternal obesity or gestational diabetes mellitus (GDM) affect infant body size and body composition during the first year of life.

Methods: Eighty three normal-weight (NW) women, 26 obese (OB) women, and 26 women with GDM were recruited during pregnancy. Infant body composition was determined by air-displacement plethysmography at 1 and 12 weeks, and anthropometric measurements made until 1 year of age. Read More

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http://dx.doi.org/10.1038/s41390-018-0248-9DOI Listing
February 2019
1 Read

Angiotensin inhibition in the developing kidney; tubulointerstitial effect.

Pediatr Res 2019 Jan 25. Epub 2019 Jan 25.

Department of Pediatrics, College of Medicine, Korea University, Seoul, 02841, Korea.

Background: Renin-angiotensin system (RAS) blockade during nephrogenesis causes a broad range of renal mal-development. Here, we hypothesized that disruption of renal lymphangiogenesis may contribute to tubulointerstitial alterations after RAS blockade during kidney maturation.

Methods: Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle for 7 days after birth. Read More

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http://dx.doi.org/10.1038/s41390-019-0288-9DOI Listing
January 2019
1 Read

In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging.

Pediatr Res 2019 Jan 25. Epub 2019 Jan 25.

Division of Diagnostic Imaging & Radiology, Children's National Health System, 111 Michigan Ave. NW, Washington, DC, 20010, USA.

Background: The objective of this study was to characterize structural changes in the healthy in vivo placenta by applying morphometric and textural analysis using magnetic resonance imaging (MRI), and to explore features that may be able to distinguish placental insufficiency in fetal growth restriction (FGR).

Methods: Women with healthy pregnancies or pregnancies complicated by FGR underwent MRI between 20 and 40 weeks gestation. Measures of placental morphometry (volume, elongation, depth) and digital texture (voxel-wise geometric and signal-intensity analysis) were calculated from T2W MR images. Read More

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http://dx.doi.org/10.1038/s41390-019-0311-1DOI Listing
January 2019

An educational intervention for NICU staff decreased maternal postpartum depression.

Pediatr Res 2019 Jan 23. Epub 2019 Jan 23.

Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.

Background: Mothers of preterm infants are at increased risk for postpartum depression, which may disturb parenting and child development. Strategies for prevention are needed. Therefore, we evaluated how an educational intervention for neonatal staff affected depression symptoms among mothers of preterm infants. Read More

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http://www.nature.com/articles/s41390-019-0306-y
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http://dx.doi.org/10.1038/s41390-019-0306-yDOI Listing
January 2019
1 Read

The point-of-care Bilistick method has very short turn-around-time and high accuracy at lower cutoff levels to predict laboratory-measured TSB.

Pediatr Res 2019 Jan 23. Epub 2019 Jan 23.

Department of Paediatrics, Hospital Ampang, Selangor, Malaysia.

Background: This study aimed to determine the accuracy of a point-of-care Bilistick method for measuring total serum bilirubin (TSB) and its turn-around-time (TAT) against hospital laboratory methods.

Methods: This prospective study was carried out on 561 term-gestation jaundiced neonates in two Malaysian hospitals. Venous blood sample was collected from each neonate for contemporary measurement of TSB by hospital laboratories and Bilistick. Read More

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http://dx.doi.org/10.1038/s41390-019-0304-0DOI Listing
January 2019

The effects of neuroblastoma and chemotherapy on metabolism, fecal microbiome, volatile organic compounds, and gut barrier function in a murine model.

Pediatr Res 2019 Jan 16. Epub 2019 Jan 16.

Department of Paediatric and Adolescent Surgery, Medical University of Graz, Graz, Austria.

Background: Following transplantation of human neuroblastoma (NB) cells into athymic mice, we investigated the effects of tumor growth and cyclophosphamide (CTX) treatment on systemic metabolism, gut inflammation and permeability, fecal microbiome and volatile organic compounds (VOCs).

Methods: NB cells (MHH-NB11) were implanted into athymic mice (n=20); 20 healthy mice served as controls (sham).  CTX was given to 20 animals (10 NB and 10 sham) after 8 and 9 weeks. Read More

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http://www.nature.com/articles/s41390-019-0283-1
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http://dx.doi.org/10.1038/s41390-019-0283-1DOI Listing
January 2019
4 Reads

Glycoprotein acetyls (GlycA) at 12 months are associated with high-sensitivity C-reactive protein and early life inflammatory immune measures.

Pediatr Res 2019 Jan 26. Epub 2019 Jan 26.

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/s41390-019-0307-xDOI Listing
January 2019
1 Read
2.314 Impact Factor

Maternal folic acid supplementation reduces the severity of cleft palate in Tgf-β null mutant mice.

Pediatr Res 2019 Jan 15. Epub 2019 Jan 15.

Departamento de Anatomía y Embriología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

Background: Cleft palate (CP) constitutes the most frequently seen orofacial cleft and is often associated with low folate status. Folate plays an essential role in the human body as a major coenzyme in one-carbon metabolism, including DNA synthesis, repair, and methylation. Whether the administration of isolated folic acid (FA) supplements prevents the CP caused by genetic mutations is unknown, as is its effect on the mechanisms leading to palate fusion. Read More

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http://www.nature.com/articles/s41390-018-0267-6
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http://dx.doi.org/10.1038/s41390-018-0267-6DOI Listing
January 2019
3 Reads

Irisin serum levels are positively correlated with bone mineral status in a population of healthy children.

Pediatr Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Emergency and Organ Transplantation, School of Medicine-University of Bari, Bari, Italy.

Background: Irisin is a myokine secreted by skeletal muscle during physical activity. Irisin treatment increased cortical bone mineral density (BMD) in young healthy mice and restored bone and muscle mass loss in a mouse model of disuse-induced osteoporosis and muscular atrophy. In humans, Irisin was positively correlated with BMD in young athletes. Read More

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http://dx.doi.org/10.1038/s41390-019-0278-yDOI Listing
January 2019
2 Reads

Mediators of racial and ethnic disparity in mother's own milk feeding in very low birth weight infants.

Pediatr Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Pediatrics, Rush University Children's Hospital, Chicago, IL, USA.

Background: Despite high initiation rates for mother's own milk (MOM) provision, MOM feeding at discharge from the neonatal intensive care unit (NICU) drops precipitously and reveals a racial/ethnic disparity. This study sought to identify factors that (1) predict MOM feeding at NICU discharge, and (2) mediate racial/ethnic disparity in MOM feeding at discharge.

Methods: Secondary analysis of prospective cohort study of 415 mothers and their very low birth weight infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0290-2DOI Listing
January 2019

Early sleep deprivation and attention-deficit/hyperactivity disorder.

Pediatr Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong.

Background: This study aims to study prospectively specific sleep patterns and risk of ADHD after adjusting for potential confounders such as obstructive sleep apnoea (OSA) and methylphenidate use.

Methods: A population-representative sample of 514 Chinese preschool children was recruited when in kindergarten (K3). Parents reported on their socioeconomic status and children's sleep duration. Read More

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http://www.nature.com/articles/s41390-019-0280-4
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http://dx.doi.org/10.1038/s41390-019-0280-4DOI Listing
January 2019
3 Reads

Galectin-3 expression and effect of supplementation in neonatal mice with disseminated Candida albicans infection.

Pediatr Res 2019 Jan 16. Epub 2019 Jan 16.

Department of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, RI, USA.

Background: Invasive candidiasis is an important cause of fungal infections in immunocompromised patients, including premature infants. The S-type lectin, galectin-3 (gal3), is increasingly recognized for its role in antifungal host defense. This study tested the hypothesis that tissue gal3 expression is affected by disseminated infection with Candida albicans and that supplementation with gal3 will provide a benefit in this setting. Read More

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http://dx.doi.org/10.1038/s41390-019-0279-xDOI Listing
January 2019
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Packed red cell transfusion changes cerebral oxygenation and cardiac output.

Authors:
Heike Rabe

Pediatr Res 2019 Jan 15. Epub 2019 Jan 15.

Academic Department of Paediatrics, Brighton & Sussex Medical School, Brighton, UK.

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http://dx.doi.org/10.1038/s41390-019-0294-yDOI Listing
January 2019

Continuous pulse oximetry and respiratory rate trends predict short-term respiratory and growth outcomes in premature infants.

Pediatr Res 2019 Jan 14. Epub 2019 Jan 14.

Division of Neonatology, Hurley Children's Hospital, Flint, MI, 48503, USA.

Background: To examine the correlation between interval vital signs recorded by nursing staff and continuous monitor recordings, and to determine whether aggregated monitor recordings can better predict impending escalation of respiratory support in premature infants.

Method: Preterm infants on noninvasive respiratory support or room air (RA) were prospectively enrolled. Nursing-and monitor-recorded pulse oximetry (SpO2) and respiratory rates (RR) data were recorded daily. Read More

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http://www.nature.com/articles/s41390-018-0269-4
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http://dx.doi.org/10.1038/s41390-018-0269-4DOI Listing
January 2019
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aEEG and neurologic exam findings correlate with hypoxic-ischemic brain damage severity in a piglet survival model.

Pediatr Res 2019 Jan 16. Epub 2019 Jan 16.

Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.

Background: Newborn pigs offer theoretical advantages for studying newborn hypoxic-ischemic (HI) brain damage because of a development and structure similar to the human brain. However, the correlation between functional features and actual HI brain damage has not been reported.

Methods: Newborn pigs were examined daily for 3 days after a HI insult using amplitude-integrated EEG (aEEG), and a neurobehavioral score enriched with stress and social and object interaction-driven activity evaluation. Read More

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http://dx.doi.org/10.1038/s41390-019-0282-2DOI Listing
January 2019