5,890 results match your criteria Pediatric Pulmonology[Journal]


Lung function, exercise tolerance, and physical growth of children with congenital lung malformations at 8 years of age.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatric Surgery and Intensive Care, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.

Objective: To improve counseling on congenital lung malformations (CLM) by describing long-term outcomes of children either operated on or managed by observation.

Study Design: We analyzed lung function (spirometry), exercise tolerance (Bruce treadmill), and physical growth of 8-year-old children with CLM who participated in our longitudinal prospective follow-up program. The data are shown as median standard deviation scores (SDS) with IQR, or estimated marginal means (95% CI) on the basis of general linear models. Read More

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http://dx.doi.org/10.1002/ppul.24345DOI Listing

Pathogen acquisition in patients with cystic fibrosis receiving ivacaftor or lumacaftor/ivacaftor.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Background: The cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor and lumacaftor/ivacaftor improve the status of existing infections in patients with cystic fibrosis (CF). It is unknown how well these drugs protect patients against incident infections. We hypothesized that CFTR modulator treatment would decrease new infections with Pseudomonas aeruginosa or Staphylococcus aureus. Read More

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http://dx.doi.org/10.1002/ppul.24341DOI Listing

A physicians survey assessing management of pulmonary airway involvement in sickle cell disease.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Division of Respiratory and Sleep Medicine, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

Background: Airway involvement in patients with sickle cell disease (SCD) involves recurrent episodes of acute chest syndrome (ACS), co-existent asthma, lower airway obstruction (LAO), or airway hyper-responsiveness/ bronchodilator response (AHR/BDR). With increased recognition that sickle cell (SC) airway inflammation may be distinct from asthma, our aim was to study regional and individual practices among pediatric pulmonologists and elucidate the patient characteristics that determine the diagnosis of asthma or SC airway inflammation.

Methods: A cross-sectional web-based survey including 6 case scenarios on diagnosis and management of pulmonary manifestations of pediatric SC airway disease was conducted. Read More

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http://dx.doi.org/10.1002/ppul.24289DOI Listing

Rapid early increase in BMI is associated with impaired longitudinal growth in children with cystic fibrosis.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatric Endocrinology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: We aimed to assess whether final height in children with cystic fibrosis (CF) is affected by body mass index (BMI), BMI increase, pulmonary function, and cystic fibrosis-related diabetes (CFRD).

Study Design: A longitudinal, retrospective study was performed in a cohort of 57 patients with CF (30 boys, 27 girls) born between 1997 and 2001. Height and weight were recorded annually from ages 0. Read More

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http://dx.doi.org/10.1002/ppul.24343DOI Listing

The impact of mannose-binding lectin polymorphisms on lung function in primary ciliary dyskinesia.

Pediatr Pulmonol 2019 Apr 22. Epub 2019 Apr 22.

Danish Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objective: Primary ciliary dyskinesia (PCD) is a congenital lung disease that leads to recurrent and chronic lung infection. The resulting inflammation causes lung damage and declines in lung function. Mannose-binding lectin (MBL) is a first line host defense protein of importance for the innate immunity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24346
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http://dx.doi.org/10.1002/ppul.24346DOI Listing
April 2019
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Novel pediatric-automated respiratory score using physiologic data and machine learning in asthma.

Pediatr Pulmonol 2019 Apr 21. Epub 2019 Apr 21.

Department of Pediatrics, Colorado School of Medicine, The Breathing Institute, University of Colorado, Children's Hospital Colorado, Aurora, Colorado.

Objectives: Manual clinical scoring systems are the current standard used for acute asthma clinical care pathways. No automated system exists that assesses disease severity, time course, and treatment impact in pediatric acute severe asthma exacerbations.

Working Hypothesis: machine learning applied to continuous vital sign data could provide a novel pediatric-automated asthma respiratory score (pARS) by using the manual pediatric asthma score (PAS) as the clinical care standard. Read More

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http://dx.doi.org/10.1002/ppul.24342DOI Listing

Do combined upper airway cultures identify lower airway infections in children with chronic cough?

Pediatr Pulmonol 2019 Apr 21. Epub 2019 Apr 21.

School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

Background: Obtaining lower airway specimens is important for guiding therapy in chronic lung infection but is difficult in young children unable to expectorate. While culture-based studies have assessed the diagnostic accuracy of nasopharyngeal or oropharyngeal specimens for identifying lower airway infection, none have used both together. We compared respiratory bacterial pathogens cultured from nasopharyngeal and oropharyngeal swabs with bronchoalveolar lavage (BAL) cultures as the "gold standard" to better inform the diagnosis of lower airway infection in children with chronic wet cough. Read More

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http://dx.doi.org/10.1002/ppul.24336DOI Listing

Pressure support ventilation, sigh adjunct to pressure support ventilation, and neurally adjusted ventilatory assist in infants after cardiac surgery: A physiologic crossover randomized study.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.

Objectives: We sought to compare gas exchange, respiratory mechanics, and asynchronies during pressure support ventilation (PSV), sigh adjunct to PSV (PSV SIGH), and neurally adjusted ventilatory assist (NAVA) in hypoxemic infants after cardiac surgery.

Design: Prospective, single-center, crossover, randomized physiologic study.

Setting: Tertiary-care pediatric intensive care unit. Read More

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http://dx.doi.org/10.1002/ppul.24335DOI Listing
April 2019
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Wheezing independently predicts viral infection in children with community-acquired pneumonia.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Federal University of Bahia School of Medicine, Salvador, Brazil.

Aim: To assess whether there was a difference in the frequency of symptoms and signs among children with community-acquired pneumonia (CAP) with viral or bacterial infection.

Methods: A prospective cross-sectional study was conducted in Salvador, Brazil. Children less than 5-years-old hospitalized with CAP were recruited. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24339
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http://dx.doi.org/10.1002/ppul.24339DOI Listing
April 2019
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Lung clearance index for early detection of pulmonary complications after allo-HSCT in children.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Pulmonary chronic graft-vs-host disease (cGvHD) after hematopoietic stem cell transplantation (HSCT) is characterized by impairment of the small airways. Assessment of lung clearance index (LCI) gained from multiple breath washout (MBW) is more sensitive than spirometry in detection of small airways disease. The aim of this study was to describe the development of LCI during the first year after pediatric HSCT and how LCI relates to other pulmonary function parameters and cGvHD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24340
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http://dx.doi.org/10.1002/ppul.24340DOI Listing
April 2019
5 Reads

Prediction of peak oxygen uptake using the modified shuttle test - Methodological concerns and implications for clinical practice.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Exeter, United Kingdom.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24332
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http://dx.doi.org/10.1002/ppul.24332DOI Listing
April 2019
1 Read

Carbon dioxide diffusion coefficient in noninvasive high-frequency oscillatory ventilation.

Pediatr Pulmonol 2019 Apr 17. Epub 2019 Apr 17.

Division of Neonatology, Center for Pediatrics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objectives: The carbon dioxide (CO ) diffusion coefficient (DCO ) reflects CO removal during high-frequency oscillatory ventilation (HFOV). We hypothesized that despite leak flow during noninvasive HFOV (nHFOV) DCO continues to indicate ventilation efficacy.

Methods: A neonatal airway model including CO production and an adjustable oropharyngeal leak was connected to a ventilator via bi-nasal prongs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24333
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http://dx.doi.org/10.1002/ppul.24333DOI Listing
April 2019
2 Reads

Mediterranean diet during pregnancy and childhood for asthma in children: A systematic review and meta-analysis of observational studies.

Pediatr Pulmonol 2019 Apr 17. Epub 2019 Apr 17.

Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To evaluate the relationship between high adherence to the Mediterranean diet in pregnancy and childhood and the risk of asthma and wheeze in children.

Methods: We conducted searches of PubMed, EMBASE, and Cochrane Central Register of Controlled Trials from inception to 30 October 2018. Observational studies providing risk estimates and corresponding confidence intervals on the association of high adherence to the Mediterranean diet in pregnancy or childhood and the risk of asthma or wheeze in childhood were included. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24338
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http://dx.doi.org/10.1002/ppul.24338DOI Listing
April 2019
3 Reads

The correlation of adenosine challenge test results with subsequent clinical course among young children with suspected asthma: a retrospective cohort study.

Pediatr Pulmonol 2019 Apr 17. Epub 2019 Apr 17.

Pediatric Pulmonary Unit, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem, Israel.

Aim: Our aim was to evaluate the correlation of Adenosine monophosphate challenge test (AMP-PCW) results with the patients' subsequent clinical course.

Methods: We performed a 6-year retrospective cohort study of young children with suspected asthma who underwent AMP-PCW test.

Results: Fifty four children were included in the study (median age, 50. Read More

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http://dx.doi.org/10.1002/ppul.24337DOI Listing
April 2019
1 Read

Viral induced hypersecretion of mucous (VIper).

Pediatr Pulmonol 2019 Apr 8. Epub 2019 Apr 8.

Department of Respiratory Medicine, Royal Children's Hospital, Infection, Immunology and Environment Theme, Murdoch Children's Research Institute, Victoria, Australia.

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http://dx.doi.org/10.1002/ppul.24316DOI Listing
April 2019
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Reference values for spirometric parameters in healthy children living in a Colombian city located at 2640 m altitude.

Pediatr Pulmonol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.

Objectives: To identify the spirometric equations that are most appropriate for use in children and adolescents living in Bogota, Colombia after evaluating a set of relevant previously-developed equations, including the Global Lung Function Initiative (GLI) 2012 spirometry reference equations.

Methods: Healthy children aged between 6 and 17 years that were attending two randomly-selected schools in Bogota were invited to participate in the study, from January 2017 to January 2018. All participants underwent spirometry, following the procedures recommended by the American Thoracic Society/European Respiratory Society (ATS/ERS) Task Force. Read More

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http://dx.doi.org/10.1002/ppul.24331DOI Listing
April 2019
3 Reads

Identifying and treating intrinsic PEEP in infants with severe bronchopulmonary dysplasia.

Pediatr Pulmonol 2019 Apr 4. Epub 2019 Apr 4.

Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Rationale: Infants with severe bronchopulmonary dysplasia (sBPD) and airway obstruction may develop dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP ), which impairs patient/ventilator synchrony.

Objectives: To determine if PEEP is present in infants with sBPD during spontaneous breathing and if adjusting ventilator PEEP improves patient/ventilator synchrony and comfort.

Methods: Interventional study in infants with sBPD. Read More

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http://dx.doi.org/10.1002/ppul.24328DOI Listing
April 2019
1 Read

Randomized clinical trial of high concentration versus titrated oxygen use in pediatric asthma.

Pediatr Pulmonol 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatric Critical Care, The Children's Hospital at Montefiore, Bronx, New York.

Objective: To compare the effects of high concentration to titrated oxygen therapy (HCOT) on transcutaneous carbon dioxide (PtCO ) level in pediatric asthma exacerbation. Titrated oxygen therapy (TOT) in acute asthma will avoid a rise in PtCO in the pediatric population.

Method: The study design is a prospective, randomized, clinical trial comparing HCOT (maintain SpO2 92-95%) while being treated for asthma exacerbation in the emergency department (ED). Read More

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http://dx.doi.org/10.1002/ppul.24329DOI Listing
April 2019
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Novel mutations and deletions in cystic fibrosis in a tertiary cystic fibrosis center in Istanbul.

Pediatr Pulmonol 2019 Apr 2. Epub 2019 Apr 2.

Division of Pediatric Pulmonology, Faculty of Medicine, Marmara University, Istanbul, Turkey.

Background: Cystic fibrosis (CF) genotyping has garnered increased attention since the discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in 1989 led to the identification of over 1700 mutations on chromosome 7. Yet, little is known about the genetic profile of CF patients in Turkey. This study sought to determine the mutation distribution among CF patients seeking care at Marmara University. Read More

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http://dx.doi.org/10.1002/ppul.24299DOI Listing
April 2019
2 Reads

Communicating bronchopulmonary foregut malformation: Volume change of the affected lung after birth.

Pediatr Pulmonol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1002/ppul.24296DOI Listing

Mortality in infants with bronchopulmonary dysplasia: Data from cardiac catheterization.

Pediatr Pulmonol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, University of California, San Francisco, California.

Rationale: Pulmonary hypertension (PH) is relatively common in infants with severe bronchopulmonary dysplasia (BPD), however, hemodynamic data and factors associated with mortality in this patient group are sparsely described in the literature.

Objectives: To characterize the hemodynamics of former preterm infants with BPD and PH, as measured at cardiac catheterization, and to identify respiratory and cardiovascular predictors of mortality.

Methods: Single-center, retrospective cohort study, including, 30 patients born at less than 32-week gestational age (GA), who had an oxygen requirement at 36 weeks postmenstrual age and underwent cardiac catheterization between July 2014 and December 2017. Read More

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http://dx.doi.org/10.1002/ppul.24297DOI Listing
April 2019
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Hughes Stovin: Sustained remission and regression of pulmonary aneurysms with anti-tumor necrosis factor treatment.

Pediatr Pulmonol 2019 Apr 2. Epub 2019 Apr 2.

Clinical Department of Medical, Surgical and Health Science, University of Trieste, Trieste, Italy.

We report the first case of Hughes Stovin Syndrome successfully treated with long-lasting tumor necrosis factor α (TNF-α) blocker (infliximab) treatment. Because of the failure of the standard therapeutic regimen with steroids and cyclophosphamide, infliximab was started achieving a stable disease remission and a complete resolution of pulmonary aneurysms. Hughes Stovin Syndrome, although rare, is a life-threatening condition that needs to be timely identified and treated aggressively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24298
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http://dx.doi.org/10.1002/ppul.24298DOI Listing
April 2019
2 Reads

Assessing the impact of breathing retraining on asthma symptoms and dysfunctional breathing in children.

Pediatr Pulmonol 2019 Apr 1. Epub 2019 Apr 1.

Medical & Research department, NIHR Alder Hey Clinical Research Facility, Alder Hey Children's NHS Trust, Liverpool, UK.

Objective: To assess the impact of breathing retraining on asthma symptoms and dysfunctional breathing (DB) in children. Breathing retraining can improve DB but there is a lack of evidence in pediatrics.

Methods: Participants attended outpatient physiotherapy appointments and received individually tailored interventions, particularly Buteyko breathing techniques. Read More

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http://dx.doi.org/10.1002/ppul.24300DOI Listing

Nonsystemic allergic bronchopulmonary aspergillosis in cystic fibrosis: A suggested paradigm for the evolution from topical to systemic disease.

Pediatr Pulmonol 2019 Apr 1. Epub 2019 Apr 1.

Division of Pediatric Pulmonology, Miller School of Medicine, University of Miami, Miami, Florida.

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http://dx.doi.org/10.1002/ppul.24325DOI Listing
April 2019
4 Reads

Deposition studies of aerosol delivery by nasal cannula to infants.

Pediatr Pulmonol 2019 Apr 1. Epub 2019 Apr 1.

Department of Developmental Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Aim: Nasal cannulas are used to provide oxygen support for infants and have been considered as a means for delivering aerosols to the lungs. To measure mucociliary clearance in the lungs of infants with congenital heart defects, we delivered radiopharmaceutical aerosols via a nasal cannula. Here we report on the pulmonary and nasal deposition of these aerosols. Read More

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http://dx.doi.org/10.1002/ppul.24326DOI Listing
April 2019
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Nocturnal asthma is affected by genetic interactions between RORA and NPSR1.

Pediatr Pulmonol 2019 Mar 29. Epub 2019 Mar 29.

Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.

Background: Neuropeptide S Receptor 1 ( NPSR1) and Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA ) interact biologically, are both known candidate genes for asthma, and are involved in controlling circadian rhythm. Thus, we assessed (1) whether interactions between RORA and NPSR1 specifically affect the nocturnal asthma phenotype and (2) how this may differ from other asthma phenotypes.

Methods: Interaction effects between 24 single-nucleotide polymorphisms (SNPs) in RORA and 35 SNPs in NPSR1 on asthma and nocturnal asthma symptoms were determined in 1432 subjects (763 asthmatics [192 with nocturnal asthma symptoms]; 669 controls) from the Multicenter Asthma Genetic in Childhood/International Study of Asthma and Allergies in Childhood studies. Read More

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http://dx.doi.org/10.1002/ppul.24292DOI Listing
March 2019
1 Read

Perspectives on anemia and iron deficiency from the cystic fibrosis care community.

Pediatr Pulmonol 2019 Mar 28. Epub 2019 Mar 28.

Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

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http://dx.doi.org/10.1002/ppul.24323DOI Listing
March 2019
3 Reads

Intermittent hypoxia in preterm infants: Measurement using the desaturation index.

Pediatr Pulmonol 2019 Mar 28. Epub 2019 Mar 28.

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Objective: The aims of this study were to: (i) Determine in preterm infants at neonatal discharge the prevalence of intermittent hypoxia (IH), as measured by the oxygen desaturation index (DSI) recorded by pulse oximetry and (ii) Determine the change in values for very preterm infants at 1-month post discharge.

Methods: Preterm infants were recruited from the Wellington regional neonatal intensive care unit (NICU) and 24-h pulse oximetry recordings performed immediately before discharge. Infants born <32 weeks gestational age (GA) had repeat oximetry 1-month post discharge. Read More

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http://dx.doi.org/10.1002/ppul.24276DOI Listing

Diet and asthma in Lebanese schoolchildren: A cross-sectional study.

Pediatr Pulmonol 2019 Mar 28. Epub 2019 Mar 28.

Life Sciences and Health Department, Paris-Est University, Paris, France.

Objectives: The causes of the global increase in asthma in children are unknown. It has been hypothesized that diet is an important factor that may play a role in the pathogenesis of the disease. The objective was to evaluate the association between diet and current asthma among Lebanese children. Read More

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http://dx.doi.org/10.1002/ppul.24280DOI Listing
March 2019
1 Read

Postnatal gene expression of airway epithelial sodium transporters associated with birth stress in humans.

Pediatr Pulmonol 2019 Mar 28. Epub 2019 Mar 28.

Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Introduction: Lung fluid clearance is essential for successful postnatal pulmonary adaptation. The epithelial sodium channel (ENaC) and Na-K-ATPase, induced by serum- and glucocorticoid-inducible kinase 1 (SGK1) as well as aquaporins (AQP), represent key players in the switch from fetal lung fluid secretion to absorption and in early postnatal lung fluid balance. Birth stress, including a surge in catecholamines, promotes pulmonary adaptation, likely through the augmentation of epithelial sodium reabsorption. Read More

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http://dx.doi.org/10.1002/ppul.24288DOI Listing
March 2019
3 Reads

Decrease the flow setting to improve trans-nasal pulmonary aerosol delivery via "high-flow nasal cannula" to infants and toddlers.

Pediatr Pulmonol 2019 Mar 28. Epub 2019 Mar 28.

Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University Medical Center, Chicago, Illinois.

Objectives: Trans-nasal pulmonary aerosol delivery for infants and toddlers has recently gained popularity, however, the reported lung deposition is low. We aimed to investigate the influential factors to improve the delivery.

Methods: Anatomic airway manikins simulating infant (5 kg) and toddler (15 kg) with collecting filter connected the trachea and breath simulator, were set to represent quiet and distressed breathing. Read More

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http://dx.doi.org/10.1002/ppul.24274DOI Listing
March 2019
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Oxygen saturations and neurodevelopmental outcomes in single ventricle heart disease.

Pediatr Pulmonol 2019 Mar 28. Epub 2019 Mar 28.

Pediatric Pulmonary Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.

Objectives: To evaluate whether the degree of hypoxemia following stage-I and stage-II palliative surgeries predicts neurodevelopmental outcomes at 14 months of age in children with single ventricle congenital heart disease (SVCHD).

Design: We analyzed longitudinal data from two Pediatric Heart Network (PHN) randomized controlled trials, with a total of 328 subjects. Oxygen saturations, measured via pulse oximetry, at time of discharge from stage-I and stage-II surgeries were the primary predictors of interest, and Bayley Scales of Infant Development-II (BSID-II) scores at 14 months old were the primary outcome measure. Read More

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http://dx.doi.org/10.1002/ppul.24275DOI Listing

Strain matters: Murine models of BPD.

Authors:
Richard L Auten

Pediatr Pulmonol 2019 Mar 27. Epub 2019 Mar 27.

Neonatology, Women's Hospital, Cone Health System, Greensboro, North Carolina.

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http://dx.doi.org/10.1002/ppul.24322DOI Listing

Upcoming events of interest.

Authors:

Pediatr Pulmonol 2019 Apr;54(4):507

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http://dx.doi.org/10.1002/ppul.24097DOI Listing
April 2019
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Isolated pulmonary interstitial glycogenosis associated with alveolar growth abnormalities: A long-term follow-up study.

Pediatr Pulmonol 2019 Mar 25. Epub 2019 Mar 25.

Pediatric Allergy, Pulmonary and Cystic Fibrosis Section, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Introduction: Pulmonary interstitial glycogenosis (PIG) is a rare infant interstitial lung disease characterized by an increase in the number of interstitial mesenchymal cells, presenting as enhanced cytoplasmic glycogen, and is considered to represent the expression of an underlying lung development disorder.

Methods: This study describes the clinical, radiological, and functional characteristics and long-term outcomes (median 12 years) of nine infants diagnosed with isolated PIG associated with alveolar simplification in the absence of other diseases.

Results: All patients presented with tachypnea. Read More

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http://dx.doi.org/10.1002/ppul.24324DOI Listing
March 2019
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Performance of a novel reusable pediatric pulse oximeter probe.

Pediatr Pulmonol 2019 Mar 25. Epub 2019 Mar 25.

Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.

Objective: To assess the performance of reusable pulse oximeter probe and microprocessor box combinations, of varying price-points, in the context of a low-income pediatric setting.

Methods: A prospective, randomized cross-over study comparing time to biologically plausible oxygen saturation (SpO ) between: (1) Lifebox LB-01 probe with Masimo Rad-87 box (L + M) and (2) a weight-appropriate reusable Masimo probe with Masimo Rad-87 box (M + M). A post hoc secondary analysis comparison with historical usability testing data with the Lifebox LB-01 probe and Lifebox V1. Read More

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http://dx.doi.org/10.1002/ppul.24295DOI Listing

Ivacaftor drug desensitization.

Pediatr Pulmonol 2019 Mar 25. Epub 2019 Mar 25.

Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky.

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http://dx.doi.org/10.1002/ppul.24319DOI Listing
March 2019
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Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment.

Pediatr Pulmonol 2019 Mar 21. Epub 2019 Mar 21.

Departments of Paediatrics, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel.

Rationale: Necrotizing pneumonia is characterized by destruction and liquefaction of the lung tissue and loss of the normal pulmonary parenchymal architecture. During the course of resolution areas of hyperlucency are formed, sometimes with the development of giant lung cysts that can be a field with fluid resembling lung abscess. There is no consensus on the management of these abnormalities. Read More

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http://dx.doi.org/10.1002/ppul.24321DOI Listing
March 2019
1 Read

Utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration in children with mediastinal pathology.

Pediatr Pulmonol 2019 Mar 19. Epub 2019 Mar 19.

Division of Pediatric Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration (EUS-B-FNA) are useful modalities in the evaluation of mediastinal pathologies in adults. However, sparse data are available in children.

Objective: To describe the utility and safety of EBUS-TBNA and EUS-B-FNA in children with mediastinal pathologies of unknown etiology. Read More

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http://dx.doi.org/10.1002/ppul.24313DOI Listing
March 2019
1 Read

Linkage of the CF foundation patient registry with the pediatric health information system database.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Cystic Fibrosis Foundation, Bethesda, Maryland.

Introduction: The Cystic Fibrosis Foundation Patient Registry (CFFPR) contains clinical and demographic data from ∼85% of US cystic fibrosis (CF) patients across 120 care centers, but lacks robust inpatient hospitalization data. In contrast, the Pediatric Health Information System (PHIS) database includes inpatient clinical and resource utilization data from 49 US children's hospitals. The creation of a linked CFFPR-PHIS dataset can uniquely address questions related to in-hospital pediatric CF treatment and management. Read More

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http://dx.doi.org/10.1002/ppul.24272DOI Listing
March 2019
1 Read

Comparison of heated humidified high-flow nasal cannula flow rates (1-L·kg·min vs 2-L·kg·min ) in the management of acute bronchiolitis.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, Division of Emergency Medicine, School of Medicine, Ege University, Izmir, Turkey.

Objective: We aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L·kg·min (1 L) with 2-L·kg·min (2 L) in patients with severe bronchiolitis presenting to the pediatric emergency department.

Study Design: We performed a study in which all patients were allocated to receive these two flow rates. The primary outcome was admitted as treatment failure, which was defined as a clinical escalation in respiratory status. Read More

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http://dx.doi.org/10.1002/ppul.24318DOI Listing
March 2019
1 Read

Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Telethon Kids Institute, Nedlands, Western Australia, Australia.

Rationale: Increasing evidence suggests the forced oscillation technique (FOT) has the capacity to provide non-invasive monitoring and diagnosis of respiratory disease in young children. However, which FOT outcomes provide the most pertinent clinical information is currently unknown. The aim of this study was to determine which FOT outcomes were most sensitive for differentiating between health and specific childhood respiratory disease. Read More

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http://dx.doi.org/10.1002/ppul.24286DOI Listing
March 2019
2 Reads

Physical activity among children with asthma: Cross-sectional analysis in the UK millennium cohort.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.

Background: Although beneficial for health and well-being, most children do not achieve recommended levels of physical activity. Evidence for children with asthma is mixed, with symptom severity rarely considered. This paper aimed to address this gap. Read More

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http://dx.doi.org/10.1002/ppul.24314DOI Listing
March 2019
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A pilot study of heated and humidified low flow oxygen therapy: An assessment in infants with mild and moderate bronchiolitis (HHOT AIR study).

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, Section of Pediatric Pulmonology, Kapiolani Medical Center for Women and Children, Honolulu, Hawaii.

Background: Heated and humidified high flow nasal cannula oxygen therapy has been used in children with severe bronchiolitis. No data exists in children with mild to moderate bronchiolitis requiring lower flows of heated and humidified oxygen therapy.

Methods: We conducted a prospective, randomized pilot study of standard dry oxygen (control) versus heated and humidified low flow nasal cannula (HHLFNC), <4 liters per minute (LPM) oxygen, (treatment) in healthy children ≤24 months old with bronchiolitis. Read More

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http://dx.doi.org/10.1002/ppul.24267DOI Listing
March 2019
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Ten-year-old children with a history of bronchopulmonary dysplasia have regional abnormalities in ventilation perfusion matching.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Institute of Women's and Children's Health, Department of Neonatology, Karolinska Institute and University Hospital, Stockholm, Sweden.

Aim: The ratio of ventilation to blood flow is an important determinant for regional gas exchange in the lung and hypoxemia is one of the clinical hallmarks in infants with bronchopulmonary dysplasia (BPD). We have previously demonstrated ventilation/perfusion ratio (V/Q) abnormalities in infants with BPD at 36 weekś postconceptional age. The status of V/Q matching in older children with a history of BPD in infancy is unknown. Read More

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http://dx.doi.org/10.1002/ppul.24273DOI Listing

Aerosolized agents for airway clearance in cystic fibrosis.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.

The outlook for people with cystic fibrosis (CF) has improved considerably as a result of conventional therapies including aerosolized agents for airway clearance. These will continue to play a significant role in maintaining well-being and improving survival, even as newer agents emerge that correct the underlying CF defect. In this review, we explore the evidence supporting the use of dornase alfa, hypertonic saline, and mannitol in improving mucus clearance in patients with CF from different age groups with differing disease severity. Read More

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http://dx.doi.org/10.1002/ppul.24306DOI Listing
March 2019
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Turning the tide in spinal muscular atrophy: A different respiratory course.

Authors:
Oscar H Mayer

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Division of Pulmonology, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/ppul.24315DOI Listing

Severe asthma in children-a review of definitions, epidemiology, and treatment options in 2019.

Pediatr Pulmonol 2019 Mar 18. Epub 2019 Mar 18.

Child Health, University of Aberdeen, Aberdeen, UK.

Severe asthma is a relatively uncommon condition in children but one which causes morbidity, occasionally mortality, and is a challenging condition to manage. There are several definitions of severe asthma, which have a common theme of poor control despite high dose inhaled corticosteroid treatment. Depending on the definition chosen, the prevalence of severe childhood asthma may be up to 5% within populations with asthma. Read More

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http://dx.doi.org/10.1002/ppul.24317DOI Listing
March 2019
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Severe childhood asthma exacerbations: Is treatment response variability in the genes?

Pediatr Pulmonol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1002/ppul.24309DOI Listing
March 2019
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Is it the "right" side?

Pediatr Pulmonol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1002/ppul.24302DOI Listing