703,599 results match your criteria Pediatric Neurosurgery [Journal]
Cell Physiol Biochem 2018 Dec 6;51(5):2041-2051. Epub 2018 Dec 6.
Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University and Chongqing Clinical Research Center for Geriatrics, Chongqing,
Background/aims: Alarin has been reported to be related with increased food intake and body weight. The relationship of circulating Alarin with insulin resistance or metabolic syndrome (MetS), however, is unknown. This study aimed to investigate the physiological role of Alarin and its association with MetS in humans. Read More
Early Hum Dev 2018 Dec 3;128:48-54. Epub 2018 Dec 3.
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Objective: To evaluate the relationship of parent-reported child behaviors on the Child Behavior Checklist (CBCL) to cognition, language, and motor skills on the Bayley Scales of Infant and Toddler Development - III (Bayley-III) in toddlers born extremely preterm.
Study Design: Toddlers born extremely preterm (gestational ages 22 0/7 to 26 6/7 weeks) were tested at 22-26 months corrected age with Bayley-III while parents completed the CBCL. Socio-demographic variables and medical history were recorded. Read More
Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.
Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More
Neoplasia 2018 Dec 3;21(1):74-81. Epub 2018 Dec 3.
Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany; German Cancer Consortium (DKTK), Partner Site, Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:
Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). Here, we identify the mixed-lineage kinase domain-like pseudokinase (MLKL) as an ISG in various cancer cell lines. Both type I and type II IFNs increase the expression of MLKL indicating that MLKL up-regulation is a general feature of IFN signaling. Read More
Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.
Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More
J Mol Cell Cardiol 2018 Dec 3. Epub 2018 Dec 3.
Department of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Kiel, Lübeck, Germany; Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address:
The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca, chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca. Read More
J Invest Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Department of Paediatrics, Prince of Wales Hospital, Hong Kong, SAR China.
Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors. ISAAC Phase Three surveyed children within schools (the sampling unit) on AE symptoms and potential risk factors. Read More
Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.
The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Critical Care Medicine, Guangzhou, Guangdong, China.
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS).
Objective: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS.
Methods: Lung proteome was profiled in three models of injury induced by acid instillation and/or mechanical ventilation in mice. Read More
Invest Ophthalmol Vis Sci 2018 Dec;59(15):5785-5794
Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Purpose: Posterior capsule opacification (PCO) is a complication after cataract surgery, particularly in children. Epithelial-mesenchymal transition (EMT) of lens epithelial cells, mediated by transforming growth factor beta (TGFβ), contributes to PCO. However, its pathogenesis in children is poorly understood. Read More
PLoS One 2018 6;13(12):e0208426. Epub 2018 Dec 6.
Division of Vascular Surgery, Northwestern University, Chicago, IL, United States of America.
Background: The microbiome has a functional role in a number of inflammatory processes and disease states. While neointimal hyperplasia development has been linked to inflammation, a direct role of the microbiota in neointimal hyperplasia has not yet been established. Germ-free (GF) mice are an invaluable model for studying causative links between commensal organisms and the host. Read More
PLoS One 2018 6;13(12):e0208437. Epub 2018 Dec 6.
Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, University of São Paulo, São Paulo, São Paulo, Brazil.
Background: Despite the increasing number of studies evaluating patient reported outcome measures (PROs), there is no clearness regarding which restorative treatment offers major benefits based on the pediatric patient perspective.
Aim: To compare different restorative techniques in pediatric dentistry regarding patient-reported outcomes.
Design: Literature searching was carried out on prospective studies indexed in PubMed, Scopus and OpenGrey. Read More
PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.
Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.
Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More
PLoS One 2018 6;13(12):e0208171. Epub 2018 Dec 6.
Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Background: Cystic fibrosis (CF) is a disorder affecting the respiratory, digestive, reproductive systems and sweat glands. This lethal hereditary disease has known or suspected links to the dysbiosis gut microbiota. High-throughput meta-omics-based approaches may assist in unveiling this complex network of symbiosis modifications. Read More
PLoS One 2018 6;13(12):e0208207. Epub 2018 Dec 6.
Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Background: After transplantation, cell-free DNA derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to quantify ddcfDNA levels in plasma of kidney transplant recipients thereby investigating the kinetics of this biomarker after transplantation and determining biological variables that influence ddcfDNA kinetics in stable and non-stable patients.
Materials And Methods: From 107 kidney transplant recipients, plasma samples were collected longitudinally after transplantation (day 1-3 months) within a multicenter set-up. Read More
Folia Med Cracov 2018 ;58(3):83-87
Department of Internal Medicine, General Hospital of Veria, Veria, Greece.
Meckel's diverticulum represents a remnant of the proximal end of the omphalomesenteric duct, which constitutes a connection between the middle intestine and the vitelline vesicle. It is the most common congenital anomaly of the gastrointestinal tract and is found in approximately 0.3-2% of the general population. Read More
Folia Med Cracov 2018 ;58(3):11-21
Department of Pediatric Cardiac Surgery, University Children's Hospital, Jagiellonian University Medical College, Wielicka 265, Kraków, Poland.
Background: Recoarctation (reCoA) of the aorta is a common complication afer the Norwood procedure. Untreated, it can lead to failure of the systemic ventricle and death. The main goal of the study is to define risk factors of reCoA after the Norwood procedure in hypoplastic left heart syndrome (HLHS). Read More
J Assoc Genet Technol 2018 ;44(4):137-140
Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.
Objectives: While the complete form of trisomy 22 is seemingly incompatible with life, the mosaic form is a rare syndrome associated with developmental delays, intellectual disability, and dysmorphic features. Due in part to the difficulty of analyzing chromosomal mosaicism, many instances either go undiagnosed or have their diagnosis delayed. We report a case of mosaic trisomy 22 in a diamnionic-dichorionic twin with marked growth discordance and intra-uterine growth restriction, diagnosed in a 2-year-old with developmental delays, sensorineural hearing loss, cardiac and gastrointestinal abnormalities, and osteopenia of prematurity. Read More
J Assoc Genet Technol 2018 ;44(4):135-136
Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.
Objectives: The GATA family of DNA binding proteins consists of six different transcription factors (GATA1-6), each with a diverse biologic function. The transcription factors GATA1-3 function primarily to orchestrate hematopoiesis; however, they have roles in non-hematopoietic cells as well. Much of our current knowledge of the GATA transcription factors has come through observation of disease states with known GATA mutations. Read More
J Oncol Pract 2018 Dec 6:JOP1800613. Epub 2018 Dec 6.
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; American Society of Clinical Oncology, Alexandria, VA; and Moffitt Cancer Center, Tampa, FL.
J Glob Oncol 2018 Dec(4):1-11
H. Kim Lyerly, Duke University, Durham, NC; Jun Ren, Capital University Medical Center; Zhimin Yang, China Food and Drug Administration, Beijing, People's Republic of China; Gi Hyun Kim, Korea Ministry of Food and Drug Safety, Seoul, South Korea; Sumimasa Nagai, University of Tokyo; Sumimasa Nagai, Tomohiro Yamaguchi, and Ken Hatogai, Pharmaceuticals and Medical Devices Agency; Hiroshi Katayama, National Cancer Center Hospital, Tokyo, Japan; Silvy Da Rocha Dias, European Medicines Agency, London, United Kingdom; Daniel McManus and Kathy Soltys, Health Canada, Ottawa, Ontario, Canada; Olufumilayo Olopade, University of Chicago, Chicago, IL; Nancy Goodman, Kids V Cancer, Washington, DC; Greg Reaman, US Food and Drug Administration; Thomas Gross, US National Cancer Institute, Bethesda, MD, and Renzo Canetta, Independent Consultant.
Advances in genetic sequencing and other diagnostic technologies have enabled the use of precision medicine in clinical cancer care, as well as the development of novel therapies that are targeted to specific molecular drivers of cancer. Developing these new agents and making them accessible to patients requires global clinical studies and regulatory review and approval by different national regulatory agencies. Whereas these global trials present challenges for drug developers who conduct them and regulatory agencies who oversee them, they also raise practical issues about patients with low-frequency cancers who need these therapies. Read More
Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.
Departamento de Urologia de Centro Hospitalar do Porto, Instituto de Ciências Biomédicas de Abel Salazar, Porto, Portugal.
Introduction: During the last years there has been an effort in miniaturizing the endoscopic devices. The video presents an alternative for the management of distal ureteral stone, using a ureteral access of 4.85 Fr and 27 cm of length, previously described as micro-ureteroscopy. Read More
J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261.
Tracheal stenting currently using non-degradable stents is commonplace for treatment of trauma, prolonged intubation related adult airway obstructions, and pediatric patients-associated tracheal stenosis conditions. Degradable tracheal stent placement will avoid complications of stent removal and restenosis. Widespread reports exist on degradable magnesium alloys success for orthopedic and cardiovascular applications but none to date for intra tracheal use. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Background: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a )/CD207 histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive immune systems. Patients with LCH, particularly those with multisystem (MS) involvement, can develop severe hyperinflammation mimicking that observed in HLH. Read More
Paediatr Anaesth 2018 Dec 6. Epub 2018 Dec 6.
Departments of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, United States.
Background: Surgical wound infiltration with local anesthetics is common as part of multimodal analgesia and enhanced recovery pathways in pediatric surgical patients. Liposomal bupivacaine can provide up to 92 hours of pain relief, and was approved by the U.S Food and Drug Administration for local infiltration in adults. Read More
J Trop Pediatr 2018 Dec 6. Epub 2018 Dec 6.
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning city, 530021 China.
Aim: The aim of this study was to evaluate the impact of zinc combined with probiotics (Bifico) on antibiotic-associated diarrhea (AAD) secondary to pneumonia.
Methods: A total of 50 patients with AAD secondary to pneumonia were randomly divided into a probiotics group (Bifico) and a combined group (zinc combined with Bifico) and 25 pneumonia patients without AAD as the control group. Serum levels of zinc, diamine oxidase (DAO) activity, D-lactate and intestinal flora [Bifidobacterium, Escherichia coli and Bifidobacterium/E. Read More
Nicotine Tob Res 2018 Dec 6. Epub 2018 Dec 6.
Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA.
Introduction: National and international organizations have done an excellent job of advocating and promoting breast feeding for all mothers. This study assessed to what extent an intervention increased delivery of cessation assistance to breast-feeding mothers who smoke.
Methods: Data were collected between April and October 2015 in five US states as part of a cluster randomized controlled trial in 10 pediatric practices. Read More
Gigascience 2018 Dec 1;7(12). Epub 2018 Dec 1.
Centre for Marine Bio-Innovation and School of Biological, Earth and Environmental Sciences, The University of New South Wales, Sydney, 2052, Australia.
JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.
Center for Health Policy at Meharry Medical College, Nashville, Tennessee.
Pediatr Crit Care Med 2018 Dec;19(12):1180-1181
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH Center for Telehealth, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Pediatr Crit Care Med 2018 Dec;19(12):1177-1178
Department of Pediatrics, Sections of Pediatric Critical Care and Pediatric Hematology, Oncology and Bone Marrow Transplantation, University of Colorado School of Medicine, Aurora, CO Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, CO Section of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Pediatr Crit Care Med 2018 Dec;19(12):1175-1176
Division of Pediatric Critical and Emergency Care, Neonatal and Pediatric Intensive Care Unit, Verona University Hospital, Verona, Italy.
Pediatr Crit Care Med 2018 Dec;19(12):1173-1174
Division of Pediatric Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH.
Pediatr Crit Care Med 2018 Dec;19(12):1169-1172
Departments of Surgery and Pediatrics, Tufts University School of Medicine, Boston, MA.
Pediatr Crit Care Med 2018 Dec;19(12):1168-1169
Departments of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Pediatr Crit Care Med 2018 Dec;19(12):1130-1136
All authors: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Objectives: High Vasoactive-Inotropic Scores have demonstrated association with poor outcomes in pediatric cardiac ICUs and are being calculated more frequently in studies of critically ill noncardiac patients. Available studies differ in their approach to assigning Vasoactive-Inotropic Scores, making direct comparisons difficult. The goal of this investigation is to compare multiple approaches to Vasoactive-Inotropic Score assignment to determine their strength of association with mortality in a general pediatric intensive care population. Read More
Med Care 2018 Dec 4. Epub 2018 Dec 4.
Department of Health Services Administration, University of Maryland School of Public Health, College Park, MD.
Background: Newborn care is one of the most frequent types of hospitalization and Medicaid covers over 50% of all births nationwide. However, little is known about regional variation in Medicaid newborn care spending and its drivers.
Objectives: To measure the contribution of market-level prices, utilization, and health risk on regional variation in spending among newborn Medicaid population in Texas. Read More
Med Care 2018 Dec 4. Epub 2018 Dec 4.
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health.
Background: Inpatient portals are online patient portals linked to electronic health records that provide hospitalized patients and caregivers secure access to real-time clinical information and tools to enhance their communication with providers and hospital experience.
Objective: The main objective of this commentary was to provide a perspective that inpatient portals are innovative tools poised to engage patients and caregivers during hospitalization and, thus, enhance patient-centered care.
Results: Inpatient portals are desired by patients and caregivers and may contribute to improved recognition of their inpatient care team, knowledge of their treatment plan and overall inpatient experience. Read More
Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.
Rare Cancer Center.
NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. Read More
Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.
Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
Hand-sewing (HS) and stapling are common parenchymal closure techniques after distal pancreatectomy. However, these methods cannot completely prevent postoperative pancreatic fistula (POPF). The mechanisms of POPF formation after closure are unknown. Read More
Acad Med 2018 Dec 4. Epub 2018 Dec 4.
K.J. Kemper is founding director, Center for Integrative Health and Wellness and professor of pediatrics, The Ohio State University, Columbus, Ohio. H. McClafferty is director, Pediatric Integrative Medicine in Residency Program and co-director, the Fellowship in Integrative Medicine, The University of Arizona Center for Integrative Medicine, The University of Arizona College of Medicine, Tucson, Arizona. P.M. Wilson is assistant professor, Division of Emergency Medicine, Children's Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, Pennsylvania. J.R. Serwint is professor emeritus of pediatrics, Johns Hopkins University, Baltimore, Maryland. M. Batra is associate program director, Pediatric Residency Program and associate professor of pediatrics, Seattle Children's Hospital and the University of Washington in Seattle, Washington. J.D. Mahan is director, Pediatric Residency Program and professor of pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio. C.J. Schubert is professor of pediatrics, Cincinnati Children's Hospital Medical Center and The University of Cincinnati, Cincinnati, Ohio. B.B. Staples is director, Pediatric Residency Program and associate professor of pediatrics, Duke University Medical Center, Durham, North Carolina. A. Schwartz is Michael Reese Endowed Professor of Medical Education and director of research, University of Illinois College of Medicine, Chicago, Illinois, and data analyst, Association of Pediatric Program Directors Longitudinal Educational Assessment Research Network.
Purpose: Burnout symptoms are common among health professionals. Gaps remain in understanding both the stability of burnout and compassion over time and relationships among burnout, self-compassion, stress, and mindfulness in pediatric residents.
Method: The authors conducted a prospective cohort study of residents at 31 U. Read More
Acad Med 2018 Dec 4. Epub 2018 Dec 4.
B. Frush is a first-year resident in internal medicine-pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee. The author was a fourth-year medical student, University of North Carolina School of Medicine, Chapel Hill, North Carolina, at the time of writing. J. Byerley is professor of pediatrics, vice dean for education, and chief education officer, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Within the Match process, current residency interview practices are inefficient for both applicants and programs. Problems include disorganized interview offers and scheduling, excessive numbers of applicant interviews, unclear postinterview communication policies, and the significant expenses entailed. To address these issues, the authors propose applying a quality improvement approach to create a high-value interview process that would decrease investments of time, money, and energy and improve the quality of the Match experience for both applicants and programs. Read More
Simul Healthc 2018 Dec;13(6):413-419
From the Department of Medicine, University of Florida, College of Medicine (C.A.R., J.M.M.), University of Florida Health Science Center Libraries (H.F.N.); Division of Medical Education, Department of Pediatrics (E.B.), Division of Cardiovascular Medicine, Department of Medicine (D.E.W.), University of Florida, College of Medicine, Gainesville, FL.
Statement: We identified 24 studies of high-fidelity simulation being used to teach echocardiography. A variety of study designs were used with outcomes ranging from reports of learner self-confidence up to improvement in organizational practice. Most studies were carried out in graduate medical populations, specifically in anesthesia trainees. Read More
J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.
From the Department of Orthopaedics (Dr. R. F. Murphy, Dr. Plumblee, Dr. Barfield, and Dr. Dow), Medical University of South Carolina, Charleston SC, Children's Orthopaedics of Atlanta, Atlanta, GA (Dr. J. S. Murphy, Mr. Fuerstenau), the Department of Orthopaedics and Biomedical Engineering, University of Tennessee-Campbell Clinic, Memphis, TN (Dr. Spence and Dr. Kelly), and Shriner's Hospital for Children, Springfield, MA (Dr. Mooney).
Introduction: Septic arthritis of the hip (SAH) is a common condition encountered by pediatric orthopaedic surgeons and is treated with arthrotomy and irrigation. Depending on the response to initial treatment, some patients require surgical treatment beyond the index procedure. The purpose of this study was to investigate risk factors for repeat surgical intervention after initial arthrotomy for presumed SAH. Read More
Pediatr Crit Care Med 2018 Dec 4. Epub 2018 Dec 4.
Department of Critical Care, Children's National Health System, Washington, DC.
Objectives: Describe a single center experience of hemophagocytic lymphohistiocytosis in a PICU over a 10-year period, to identify clinical features that may be associated with worse outcomes, including mortality, hospital and ICU length of stay, and functional and cognitive impairments on discharge.
Design: Retrospective electronic medical record review, 2007-2017.
Setting: PICU located in a large urban academic quaternary care children's hospital. Read More
Shock 2018 Jul 30. Epub 2018 Jul 30.
Department of Pathology and Medical Biology, Medical Biology section.
Tie2 is a tyrosine kinase receptor that is mainly expressed by endothelial cells. In animal models mimicking critical illness, Tie2 levels in organs are temporarily reduced. Functional consequences of these reduced Tie2 levels on microvascular endothelial behaviour are unknown. Read More
J Pediatr Hematol Oncol 2018 Dec 4. Epub 2018 Dec 4.
Departments of Otolaryngology-Head and Neck Surgery.
This study sought to examine if modern medical evaluations including newborn screening and early diagnosis along with better methods of disease control have improved rates of hearing loss in children with sickle cell disease (SCD). Audiometric and medical data for patients with SCD was obtained from the AudGen Database and analyzed for the presence of hearing loss, type of hearing loss, severity of hearing loss, and correlation with comorbid conditions. Children with sickle cell trait (SCT) were used as a comparison group. Read More