5,297 results match your criteria Pediatric Neurology[Journal]


Arrest of Fetal Brain Development in ALG11-Congenital Disorder of Glycosylation.

Pediatr Neurol 2018 Dec 24. Epub 2018 Dec 24.

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

Background: Arrest of fetal brain development and the fetal brain disruption sequence describe a severe phenotype involving microcephaly, occipital bone prominence, and scalp rugae. Congenital disorders of glycosylation are a heterogeneous group of inherited disorders involved in glycoprotein and glycolipid biosynthesis, which can cause microcephaly and severe neurodevelopmental disability.

Methods: We report an example of fetal microcephaly diagnosed at 36 weeks' gestation with a history of normal fetal biometry at 20 weeks' gestation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183115
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.009DOI Listing
December 2018
1 Read

Macroglossia, Dry Skin, Developmental Delay, and Stippled Epiphysis: A Treatable Condition.

Pediatr Neurol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.001DOI Listing
January 2019

Genotypic Spectrum and Natural History of Cavitating Leukoencephalopathies in Childhood.

Pediatr Neurol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, Peking University First Hospital, Beijing, China. Electronic address:

Background: We aimed to delineate the pattern of natural course, neuroimaging features, and the genotypic spectrum of cavitating leukoencephalopathies.

Methods: Children (age of onset ≤16 years) who met the criteria for cavitating leukoencephalopathies from January 2009 to October 2018 were identified. Whole-exome sequencing and prospective follow-up study of the natural history and brain magnetic resonance imaging (MRI) were performed. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.002DOI Listing
January 2019

Vacuum Extraction in Preterm Deliveries and Long-Term Neurological Outcome of the Offspring.

Pediatr Neurol 2019 Jan 15. Epub 2019 Jan 15.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

Background: Concern exists regarding a possible harmful impact of vacuum extraction on the preterm newborn. We aimed to evaluate the long-term pediatric neurodevelopmental outcomes of the preterm offspring after vacuum extraction.

Methods: A population-based cohort analysis was performed comparing the risk for long-term neurological morbidity (up to age 18 years) in preterm (less than 37 completed weeks of gestation) children born via following three delivery modes: vacuum extraction, spontaneous delivery, and cesarean delivery performed during the second stage of labor. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.010DOI Listing
January 2019
1 Read

Where to From Here?

Authors:
Nomazulu Dlamini

Pediatr Neurol 2018 Dec 20. Epub 2018 Dec 20.

Division of Neurology, The Hospital for Sick Children, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.004DOI Listing
December 2018

Children With Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure, What Does it Mean? A Review of the Literature.

Pediatr Neurol 2019 Jan 11. Epub 2019 Jan 11.

Division of Neurosurgery, Nationwide Children's Hospital, Columbus, Ohio.

Severe traumatic brain injury is a leading cause of morbidity and mortality in children. In 2003 the Brain Trauma Foundation released guidelines that have since been updated (2010) and have helped standardize and improve care. One area of care that remains controversial is whether the placement of an intracranial pressure monitor is advantageous in the management of traumatic brain injury. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.003DOI Listing
January 2019

Cerebral Hemodynamics During Neonatal Cerebrospinal Fluid Removal.

Pediatr Neurol 2019 Jan 8. Epub 2019 Jan 8.

Division of Neonatology, Institute for Maternal and Child Health, IRCSS "Burlo Garofolo", Trieste, Italy. Electronic address:

Background: Standard treatment of neonatal posthemorrhagic hydrocephalus is cerebrospinal fluid removal. The aim of this study was to assess how much cerebrospinal fluid volume removal, by ventricular reservoir taps, is needed to improve cerebral hemodynamics and oxygenation in neonatal posthemorrhagic hydrocephalus.

Methods: Cerebral hemodynamics and oxygenation were continuously monitored by near-infrared spectroscopy in four newborns (one term and three preterm) during 28 ventricular reservoir taps. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.005DOI Listing
January 2019
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Pediatric Epilepsy Readmissions: The Who, When, and Why.

Pediatr Neurol 2018 Dec 25. Epub 2018 Dec 25.

Division of Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Prior studies have demonstrated a pediatric epilepsy readmission rate of 6% to 10% but have not described details of the readmitted patients. We report the characteristics of pediatric patients admitted for epilepsy who were readmitted to the hospital within 30 days of discharge.

Methods: An interdisciplinary team was established to individually review and characterize the 30-day readmissions of patients admitted for epilepsy from May 2014 to October 2016. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.007DOI Listing
December 2018

Ketogenic Diet in Epilepsy of Infancy With Migrating Focal Seizures.

Pediatr Neurol 2019 Jan 7. Epub 2019 Jan 7.

Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183134
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.019DOI Listing
January 2019
2 Reads

Use of Venous Pco in Determination of Death by Neurological Criteria in Children.

Pediatr Neurol 2018 Dec 19. Epub 2018 Dec 19.

Pediatric Neurology, Miller Children's & Women's Hospital of Long Beach, Long Beach, California.

Background: Compare the increase in partial pressure of carbon dioxide (Pco) from venous blood samples with that of arterial blood samples during apnea challenge test in determination of death by neurological criteria.

Methods: Prospective nonrandomized cohort study in tertiary care pediatric intensive care unit. Patients older than 37 week's gestation admitted to PICU with irreversible brain injury at the time when attending physician will perform apnea challenge test as part of brain death examination from October 2015 till September 2017. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.001DOI Listing
December 2018

Necessity of Intracranial Imaging in Infants and Children With Macrocephaly.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Department of Pediatrics, Sanford USD Medical Center, Sanford Children's Hospital, Sioux Falls, South Dakota; University of South Dakota Sanford School of Medicine, Vermillion, South Dakota. Electronic address:

Background: Macrocephaly is frequently encountered in pediatrics and often leads to imaging. There are no recommendations from the American Academy of Pediatrics or the American College of Radiology providing imaging guidelines for macrocephaly. The goal of this study is to identify risk factors for pathologic macrocephaly and to aid the clinician in identifying patients that would benefit from imaging. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.018DOI Listing
November 2018

Prognostic Value of Electroencephalography in Hypothermia-Treated Neonates With Hypoxic-Ischemic Encephalopathy: A Meta-Analysis.

Pediatr Neurol 2018 Dec 28. Epub 2018 Dec 28.

Department of Pediatrics, Peking University People's Hospital, Beijing, China. Electronic address:

Background: Electroencephalography (EEG) background activity is associated with neurological outcome in neonates with hypoxic-ischemic encephalopathy. There is uncertainty about the prognostic value of EEG background activity after hypothermia was introduced.

Methods: Searches were made on Pubmed, Embase, and the Cochrane Library, from inception to March 1, 2018. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.013DOI Listing
December 2018
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Reply to Finsterer Regarding Lethal NARS2-Related Disorder Associated With Rapidly Progressive Intractable Epilepsy and Global Brain Atrophy.

Pediatr Neurol 2018 Nov 28. Epub 2018 Nov 28.

Helen DeVos Children's Hospital, Grand Rapids, MI, USA; College of Human Medicine Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.013DOI Listing
November 2018

Cerebral Infarction in CARS2 Mutation.

Authors:
Debopam Samanta

Pediatr Neurol 2018 Dec 24. Epub 2018 Dec 24.

Child Neurology Section, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.005DOI Listing
December 2018

CNTNAP1-Related Congenital Hypomyelinating Neuropathy.

Pediatr Neurol 2018 Dec 28. Epub 2018 Dec 28.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio. Electronic address:

Background: Congenital hypomyelinating neuropathy is a rare form of hereditary peripheral neuropathy characterized by nonprogressive weakness, areflexia, hypotonia, severely reduced nerve conduction velocities, and hypomyelination. Mutations in contactin-associated protein 1 (CNTNAP1) were recently described as a cause of congenital hypomyelinating neuropathy. CNTNAP1-associated congenital hypomyelinating neuropathy is characterized by severe hypotonia, multiple distal joint contractures, and high mortality in the first few months of life. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.014DOI Listing
December 2018

Flunarizine for Headache Prophylaxis in Children With Sturge-Weber Syndrome.

Pediatr Neurol 2018 Nov 28. Epub 2018 Nov 28.

Neurosciences, Great Ormond Street Hospital NHS Foundation Trust, London, UK; Clinical Neurosciences, UCL- Institute of Child Health, London, UK.

Background: Children with Sturge-Weber syndrome can experience severe headache with or without transient hemiparesis. Flunarizine, a calcium antagonist, has been used for migraine. The experience with flunarizine for headache in a cohort of children at a national center for Sturge-Weber syndrome is reviewed, reporting its efficacy and adverse effect in this population. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.012DOI Listing
November 2018
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Protocols and Guidelines for Stroke in Children: Point and Counterpoint.

Pediatr Neurol 2018 Dec 24. Epub 2018 Dec 24.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.008DOI Listing
December 2018

Expanding the Phenotypic Spectrum of CACNA1H Mutations.

Pediatr Neurol 2018 Dec 19. Epub 2018 Dec 19.

McGovern Medical School, UTHealth, Mitochondrial Center of Excellence, Houston, Texas.

Background: The CACNA1H gene mutations encoding the α subunit of Cav3.2 T-type calcium channels have been associated with generalized epilepsy. Focal or multifocal epilepsy and systemic (immunologic and gastrointestinal) involvement associated with these mutations have not been described previously. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.017DOI Listing
December 2018
1 Read

Jeavons Syndrome: An Overlooked Epilepsy Syndrome.

Pediatr Neurol 2018 Dec 28. Epub 2018 Dec 28.

Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.016DOI Listing
December 2018

Nerve Transfers in Acute Flaccid Myelitis: A Beacon of Hope.

Pediatr Neurol 2018 Dec 29. Epub 2018 Dec 29.

Child Neurology Division, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.12.018DOI Listing
December 2018

Formation and Growth of the Child Neurology Society.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Division of Pediatric Neurology, Professor Emeritus of Neurology and Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.

The Child Neurology Society, founded in 1972, has developed into a strong and vibrant voice for professionals who care for children with a wide variety of neurological disorders. In this article, we describe its beginnings, growth, and how the Society has established robust relationships with many professional societies, and most importantly, the National Institute of Neurological Disorders and Stroke, in fostering research, education, and training for those in the field. The Child Neurology Society was also instrumental in helping to establish the Professors of Child Neurology and the Child Neurology Foundation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183115
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.001DOI Listing
November 2018
2 Reads

Visual Complications of Pediatric Posterior Fossa Tumors: Analysis of Outcomes.

Pediatr Neurol 2018 Oct 18. Epub 2018 Oct 18.

Department of Ophthalmology, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas. Electronic address:

Objective: Visual abnormalities are common among children with posterior fossa tumors, resulting from disruption of ocular afferent and efferent systems due to the tumor or surgery. This study describes the visual complications and outcomes associated with these tumors.

Methods: Clinical and radiographic data of patients who underwent index surgery for resection of posterior fossa tumor from 2007 to 2016 were reviewed. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.09.016DOI Listing
October 2018
2 Reads

Infant Botulism With Asymmetric Cranial Nerve Palsies.

Pediatr Neurol 2018 Nov 30. Epub 2018 Nov 30.

Baylor College of Medicine, Department of Pediatrics, Section of Neurology and Developmental Neuroscience, Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.016DOI Listing
November 2018
2 Reads

Reversible Cerebral Vasoconstriction Syndrome: A Novel Mechanism for Neurological Complications in Schimke Immuno-osseous Dysplasia.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Division of Pediatric Neurology, Department of Pediatrics and Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center Dallas, Dallas, Texas; Children's Health System of Texas, Dallas, Texas.

Background: Schimke immuno-osseous dysplasia is a rare autosomal recessive disease resulting from biallelic SMARCAL1 mutations. It presents in early childhood and is characterized by short stature, nephropathy, and immunodeficiency. Approximately 50% of those affected have neurological complications including migraines, transient ischemic attacks, and strokes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183079
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.022DOI Listing
November 2018
3 Reads

Rapidly Progressing Brain Atrophy in a Child With Developmental Regression.

Pediatr Neurol 2018 Nov 24. Epub 2018 Nov 24.

Department of Child Neurology, Medical University of Warsaw, Warsaw, Poland.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.009DOI Listing
November 2018

Fluorodeoxyglucose Detected Changes in Brain Metabolism After Chemotherapy in Pediatric Non-Hodgkin Lymphoma.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Nuclear Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Background: Potential neurocognitive dysfunction after chemotherapy is a worrisome long-term outcome. Our objective was to evaluate the effect on brain metabolism in pediatric patients with non-central nervous system cancer treated with chemotherapy by analyzing brain data from serial whole-body fluorodeoxyglucose positron emission tomography/computed-tomography (FDG-PET/CT) scans taken before and sequentially after therapy.

Methods: Fourteen pediatric patients diagnosed with lymphoma and treated with systemic and prophylactic intrathecal chemotherapy were included. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.019DOI Listing
November 2018
1 Read

Brain Development Measured With MRI in Children With Down Syndrome Correlates With Blood Biochemical Biomarkers.

Pediatr Neurol 2018 Oct 16. Epub 2018 Oct 16.

Department of Endocrinology and Genetic Metabolic Disease, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China. Electronic address:

Background: Down syndrome (DS) is a neurodegenerative disease with unknown mechanisms. β-Amyloid peptide (Aβ) and tau protein (Tau) are known to play a role, while vitamin A (VA) has an effect on normal neurological function. In a case-control study, we quantitatively evaluated whole brain and hippocampal volumes of DS children and analyzed the correlation of hippocampal volumes with blood levels of Aβ, Tau and VA. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.007DOI Listing
October 2018
1 Read

Focal Status Epilepticus-Related Unilateral Brain Edema: Magnetic Resonance Imaging Study of Children in Southwest China.

Pediatr Neurol 2018 Nov 23. Epub 2018 Nov 23.

Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, PR China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, PR China; Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, PR China; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing, PR China. Electronic address:

Background: Unilateral brain edema is a rare peri-ictal imaging abnormality related to focal status epilepticus. We present the largest series of these patients, describe their clinical features and magnetic resonance imaging (MRI) findings, and analyze the possible underlying pathophysiology.

Methods: We reviewed the medical records in Southwest China's largest tertiary's children's medical center from 2011 to 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183049
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.08.028DOI Listing
November 2018
5 Reads

Pediatric West Nile Virus-Associated Neuroinvasive Disease: A Review of the Literature.

Pediatr Neurol 2018 Nov 28. Epub 2018 Nov 28.

Section of Child Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas.

Over the past two decades, West Nile virus has become the most common arbovirus in North America, leading to several outbreaks and infecting thousands of people. Mosquitos help transmit the virus in the majority of cases, but transmission occurs via blood transfusions, organ transplantation, and possibly pregnancy and breastfeeding. While most infected patients experience mild to no symptoms, thousands of West Nile virus-associated neuroinvasive cases have been reported in the United States, with over 700 cases occurring in children from 2003 to 2016. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.07.019DOI Listing
November 2018
1 Read

Management of Excessive Daytime Sleepiness in Narcolepsy With Baclofen.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Pediatric Neurology Service Line for Northwell Health, Department of Pediatrics & Neurology, Zucker School of Medicine at Hofstra/Northwell, Cohen Children's Medical Center, Lake Success, New York; Division of Pediatric Neurology, Department of Pediatrics, Cohen Children's Medical Center, Lake Success, New York; Pediatric Sleep Program (Neurology), Department of Pediatrics, Cohen Children's Medical Center, Lake Success, New York. Electronic address:

Background: Narcolepsy is a disabling sleep-wake disorder characterized by the pentad symptoms of excessive daytime sleepiness, sleep paralysis, sleep fragmentation, sleep-related hallucinations, and cataplexy. There is no curative therapy for narcolepsy. Treatment is therefore symptom directed. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.020DOI Listing
November 2018
2 Reads

Evaluation of Heart Rate Variability in Children With Breath-Holding Episodes.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Aim: We evaluated heart rate variability in children with breath-holding episodes (BHEs).

Methods: Sixty children with BHEs were included in the study; these individuals were further subdivided into children with cyanotic BHEs (n = 42) and children with pallid BHE (n = 18). Sixty healthy children of matched age and sex served as a control group. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.016DOI Listing
November 2018

Speech and Language Impairments After Childhood Arterial Ischemic Stroke: Does Hemisphere Matter?

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Speech and Language Group, Murdoch Children's Research Institute, Melbourne, Australia; Department of Audiology and Speech Pathology, School of Health Sciences, University of Melbourne, Melbourne, Australia. Electronic address:

Background: The association between left hemisphere stroke and acute speech and language impairment is well documented in adults. However, little is known about this association in childhood arterial ischemic stroke. Here we examined potential predictors of acute speech (dysarthria and apraxia) and language impairments after childhood arterial ischemic stroke, including site of lesion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183051
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.006DOI Listing
November 2018
7 Reads

Pre-Nusinersen Hospitalization Costs of Children With Spinal Muscular Atrophy.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Division of Critical Care, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.002DOI Listing
November 2018

Multiple Intracranial Cystic Brain Lesions: A Diagnostic Dilemma.

Pediatr Neurol 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurology, IHBAS (Institute of Human Behaviour & Allied Sciences), New Delhi, India.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.015DOI Listing
November 2018
1 Read

Neurological Complications of Congenital Zika Virus Infection.

Pediatr Neurol 2019 Feb 22;91:3-10. Epub 2018 Nov 22.

Department of Pediatrics, School of Medicine, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. Electronic address:

Background: In utero Zika virus infection resulted in many newborns with congenital defects; this public health issue was followed by unprecedented scientific productivity in this field. Many questions remain about congenital Zika virus infection and its maternal transmission, pathogenesis, clinical events, and the resulting neurological damage. There are few review articles that synthesize the current knowledge of congenital neurological complications as well as the gaps in the pediatric literature. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.003DOI Listing
February 2019
1 Read

Management of NARS2-Related Mitochondrial Disorder is Complex.

Authors:
Josef Finsterer

Pediatr Neurol 2018 Nov 27. Epub 2018 Nov 27.

Krankenanstalt Rudolfstiftung, Messerli Institute, Veterinary University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.014DOI Listing
November 2018

The "Toenail Sign" in MELAS May Be the End Stage of a Stroke-like Lesion.

Authors:
Josef Finsterer

Pediatr Neurol 2018 Nov 23. Epub 2018 Nov 23.

Krankenanstalt Rudolfstiftung, Messerli Institute, Veterinary University of Vienna, Vienna. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.008DOI Listing
November 2018

Diagnostic Yield of Intellectual Disability Gene Panels.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Division of Pediatric Neurology, Departments of Pediatrics and Neurology & Neurosurgery, McGill University, Montreal, Canada. Electronic address:

Background: Recent technological advances have improved the understanding and identification of the genetic basis of intellectual disability (ID) and global developmental delay (GDD). Next-generation sequencing panels of ID genes are now available for clinical testing; however, their overall yield in clinical practice has not yet been investigated.

Aim: We determined the diagnostic yield of ID gene panels in a clinical setting and explored whether any clinical features are associated with an increased diagnostic yield. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.005DOI Listing
November 2018
11 Reads

A Rare Presentation of Myelin Oligodendrocyte Glycoprotein IgG-Associated Optic Neuritis.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Department of Radiology, Jubilee Mission Medical College Hospital and Research Institute, Thrissur, Kerala, India.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.004DOI Listing
November 2018

A Child With Lymphangioma Due to Somatic Mutation in PIK3CA Successfully Treated With Everolimus.

Pediatr Neurol 2019 Feb 22;91:65-67. Epub 2018 Nov 22.

Department of Pediatrics, Severance Children's Hospital, College of Medicine, Yonsei University, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.017DOI Listing
February 2019

Successful Surgical Treatment of Refractory Status Epilepticus in a 12-Day-Old Infant.

Pediatr Neurol 2018 Nov 23. Epub 2018 Nov 23.

Department of Neurosurgery, Wayne State University, Detroit, Michigan; Department of Pediatric Neurosurgery, Children's Hospital of Michigan, Detroit, Michigan.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.011DOI Listing
November 2018
1.504 Impact Factor

Nature's Canvas: An Infant With Stripes and Whorls.

Pediatr Neurol 2018 Nov 23. Epub 2018 Nov 23.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.010DOI Listing
November 2018
1 Read
1.504 Impact Factor

Sociodemographic Factors Associated With Hospital Care for Pediatric Migraine: A National Study Using the Kids' Inpatient Dataset.

Pediatr Neurol 2019 Feb 1;91:34-40. Epub 2018 Feb 1.

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Pediatric Neurology Health Services Research Group, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Department of Neurology, University of Pennsylvania School of Medicine, Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Although migraine often starts in childhood or adolescence, hospital care for migraine in children is not well described. We examined patient and hospital characteristics associated with hospital care for migraine among children in the United States.

Methods: We queried the Kids' Inpatient Database (2003 to 2009) for hospitalizations of children aged 3-20. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2017.10.023DOI Listing
February 2019

Predictors of Primary Intracranial Hypertension in Children Using a Newly Suggested Opening Pressure Cutoff of 280 mm HO.

Pediatr Neurol 2019 Feb 19;91:27-33. Epub 2018 Oct 19.

Department of Emergency Medicine, Department of Informatics, Boston Children's Hospital, Boston, Massachusetts. Electronic address:

Objectives: We assessed the clinical characteristics of primary intracranial hypertension (PIH) in children using a newly recommended threshold for cerebrospinal fluid opening pressure (280 mm HO).

Method: Cross-sectional study of patients age ≤21 years who had a lumbar puncture done for evaluation of PIH. Patients were excluded if lumbar puncture was done for a suspected infection, seizure, mental status changes, multiple sclerosis, or Guillain-Barre syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183071
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.09.013DOI Listing
February 2019
8 Reads

Impaired Visual Search in Children with Rett Syndrome.

Pediatr Neurol 2018 Oct 18. Epub 2018 Oct 18.

Department of Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine/Children's Hospital at Montefiore, Bronx, New York; Rett Syndrome Center, Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine/Children's Hospital at Montefiore, Bronx, New York.

Aim: This study aims to investigate selective attention in Rett syndrome, a severely disabling neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene.

Method: The sample included 28 females with Rett syndrome (RTT) and 32 age-matched typically developing controls. We used a classic search task, in conjunction with eye-tracking technology. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.002DOI Listing
October 2018

Withdrawal of Life-Support in Neonatal Hypoxic-Ischemic Encephalopathy.

Pediatr Neurol 2019 Feb 23;91:20-26. Epub 2018 Nov 23.

Children's Hospitals Neonatal Consortium, Kansas City, MO.

Purpose: We describe the frequency and timing of withdrawal of life-support (WLS) in moderate or severe hypoxic-ischemic encephalopathy (HIE) and examine its associations with medical and sociodemographic factors.

Procedures: We undertook a secondary data analysis of a prospective multicenter data registry of regional level IV Neonatal Intensive Care Units participating in the Children's Hospitals Neonatal Database. Infants ≥36 weeks gestational age with HIE admitted to a Children's Hospitals Neonatal Database Neonatal Intensive Care Unit between 2010 and 2016, who underwent therapeutic hypothermia were categorized as (1) infants who died following WLST and (2) survivors with severe HIE (requiring tube feedings at discharge). Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.08.027DOI Listing
February 2019
1 Read

PLCB1 Biallelic Point Mutations Cause West Syndrome.

Authors:
Kenneth A Myers

Pediatr Neurol 2019 Feb 22;91:62-64. Epub 2018 Nov 22.

Research Institute of the McGill University Health Center, Montreal, Quebec, Canada; Division of Child Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183086
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.007DOI Listing
February 2019
6 Reads

In Response to "The 2017 Sachs Lecture: Kindling Knowledge in Epilepsy".

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Children's Hospital Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.021DOI Listing
November 2018

Involuntary Eye Movements Accompanied by Head Thrusting to View Objects.

Pediatr Neurol 2018 Oct 23. Epub 2018 Oct 23.

Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.09.014DOI Listing
October 2018
1 Read