1,682 results match your criteria Pediatric Diabetes [Journal]


HbA1c and retinal arteriolar narrowing in children with type 1 diabetes: the DEAR-Kids study.

Pediatr Diabetes 2019 Apr 16. Epub 2019 Apr 16.

Department of General Paediatrics, Adolescent Medicine and Neonatology, Medical Centre, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background/objective: Microvascular alterations play a key role in the development of diabetes complications. Retinal vessel analysis is a unique method to examine microvascular changes in brain derived vessels.

Subjects/methods: 67 pediatric and adolescent type 1 diabetes patients and 58 healthy control persons (mean age 12. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12858
Publisher Site
http://dx.doi.org/10.1111/pedi.12858DOI Listing
April 2019
1 Read

Role of HLA-DQ typing and anti-tTGA antibody titres in diagnosing celiac disease without duodenal biopsy in type 1 diabetes: A study of the population-based pediatric type 1 diabetes cohort of Western Australia.

Pediatr Diabetes 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Immunology, Sir Charles Gairdner Hospital, Perth, WA.

Aim: The primary aim of the current study was to determine if it is cost effective to use HLA typing as a first line screening test for celiac disease (CD) in children with type 1 diabetes (T1D), as recommended by the European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN). The second aim was to investigate whether anti-tissue transglutaminase IgA (anti-tTGA) antibodies can be used to diagnose CD without the need for a confirmatory duodenal biopsy in T1D.

Methods: Data for all T1D patients aged < 18 years, who attended the diabetes clinics in Western Australia up to June 2017, were extracted from the Western Australian Children's Diabetes Database (WACDD) and analyzed for their demographic data and CD permissive HLA alleles (DQ2, DQ8 and DQ7). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12857DOI Listing

Identification of clinically-relevant dysglycemia phenotypes based on continuous glucose monitoring data from youth with type 1 diabetes and elevated hemoglobin A1c.

Pediatr Diabetes 2019 Apr 10. Epub 2019 Apr 10.

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background And Objective: To identify and characterize subgroups of adolescents with type 1 diabetes (T1D) and elevated hemoglobin A1c (HbA1c) who share patterns in their continuous glucose monitoring (CGM) data as 'dysglycemia phenotypes.'

Methods: Data were analyzed from the Flexible Lifestyles Empowering Change randomized trial. Adolescents with T1D (13-16 years, duration>1 year, HbA1c 8-13% (64-119 mmol/mol) wore blinded CGM at baseline for 7-days. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12856
Publisher Site
http://dx.doi.org/10.1111/pedi.12856DOI Listing
April 2019
6 Reads

Utility of Waist Circumference-to-Height Ratio as a Screening Tool for Generalized and Central Obesity among Iranian Children and Adolescents: The CASPIAN-V Study.

Pediatr Diabetes 2019 Apr 9. Epub 2019 Apr 9.

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Waist-to-height ratio (WHtR) is regarded as a simple anthropometric index for evaluating central adiposity because of its independence of age, gender, and ethnicity.

Objective: The purpose of this study was to determine the optimal WHtR cutoff value in screening obesity and to compare it with other obesity indicators including body mass index (BMI) and waist circumference (WC) in Iranian children and adolescents.

Methods: This large survey was conducted on 14274 Iranian children and adolescents as a national school-based surveillance study (CASPIAN) in 2015. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12855
Publisher Site
http://dx.doi.org/10.1111/pedi.12855DOI Listing
April 2019
1 Read

Discrepancies between methods of continuous glucose monitoring in key metrics of glucose control in children with type 1 diabetes.

Pediatr Diabetes 2019 Apr 3. Epub 2019 Apr 3.

Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.

Objective: We aimed to compare glycemic control and variability parameters obtained from paired records of real-time continuous glucose monitoring (RT-CGM) and flash glucose monitoring (FGM).

Methods: Ten Polish boys and 11 girls aged 15.3 ± 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12854DOI Listing
April 2019
1 Read

Bone turnover markers in children and adolescents with Type-1-Diabetes - A systematic review.

Pediatr Diabetes 2019 Apr 3. Epub 2019 Apr 3.

Herlev University Hospital, Department of Pediatrics, Herlev, Denmark.

Background And Objectives: Type-1-Diabetes (T1D) is associated with impaired bone health and both osteocalcin and P1NP (markers of bone formation) and CTX (marker of bone resorption) are decreased in adult patients with T1D. We review the existing literature characterizing bone turnover markers in children and adolescents with T1D and by meta-analysis examine whether alterations in OCN, P1NP and CTX are evident and if potential changes correlate to the metabolic control (HbA1c).

Subjects And Methods: Systematic searches at MEDLINE and EMBASE were conducted in January 2018 identifying all studies describing OCN, P1NP or CTX in children and adolescents with T1D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12853DOI Listing
April 2019
2 Reads

Novel, culturally sensitive, shared medical appointment model for Hispanic pediatric type 1 diabetes patients.

Pediatr Diabetes 2019 Apr 1. Epub 2019 Apr 1.

Barbara Davis Center, University of Colorado, Aurora, Colorado.

Background/objective: Latino patients with type 1 diabetes (T1D) face cultural and language barriers leading to poor outcomes. Shared medical appointments (SMAs) are recognized as effective models of care. Our aim is to develop a culturally sensitive, cost effective SMA program for Latino T1D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12852DOI Listing
April 2019
2 Reads

Effect of early glycaemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic Review and Meta-analysis.

Pediatr Diabetes 2019 Apr 1. Epub 2019 Apr 1.

Great Ormond Street Institute of Child Health, University College London, UK.

Objective: A systematic review and meta-analysis was conducted to investigate if glycaemic control measured by glycated Haemoglobin (HbA1c) levels near diagnosis are predictive of future glycaemic outcomes and vascular complications in childhood onset type 1 diabetes (T1D).

Methods: Evidence was gathered using electronic databases (MEDLINE, EMBASE, Web of Science, CINAHL, Scopus and Cochrane Library up to February 2017) and snowballing techniques. Studies investigating the association between the exposure "early glycaemic control" and main outcome: "tracking of early control" and secondary outcome: risk of future complications; in children and young people aged 0 to 19 years at baseline; were systematically double-reviewed, quality assessed and outcome data extracted for synthesis and meta-analysis. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12850
Publisher Site
http://dx.doi.org/10.1111/pedi.12850DOI Listing
April 2019
2 Reads

A structured 1-year education program for children with newly diagnosed type 1 diabetes improves early glycemic control.

Pediatr Diabetes 2019 Apr 1. Epub 2019 Apr 1.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: The diagnosis of type 1 diabetes (T1D) brings significant medical, psychosocial, and educational challenges for the child, family, and medical team. We developed a structured certified diabetes educator (CDE) led program spanning the year after diagnosis with the goal of supporting families as their understanding of this chronic disease and its management evolves.

Objective: The aim of this study was to determine the effect of this program upon hemoglobin A1c (HbA1c), and how this effect is mitigated by socioeconomic status (SES). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12849DOI Listing

Prevalence, Characteristics and Diabetes Management in Children with Comorbid Autism Spectrum Disorder and Type 1 Diabetes.

Pediatr Diabetes 2019 Mar 26. Epub 2019 Mar 26.

Barbara Davis Center for Diabetes, Aurora, CO, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Objective: To determine autism spectrum disorder (ASD) prevalence within our pediatric type 1 diabetes (T1D) clinic population and determine clinical characteristics and technology use by individuals with both ASD and T1D compared to matched controls with T1D alone and compared to our overall pediatric T1D clinic.

Research Design And Methods: Medical chart review revealed 30 individuals with both ASD and type 1 diabetes (ASD+T1D). Controls (n=90) were matched for age, sex, race/ethnicity, and T1D duration. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12848
Publisher Site
http://dx.doi.org/10.1111/pedi.12848DOI Listing
March 2019
4 Reads

The association between socio-economic status and diabetes care and outcome in children with diabetes type 1 in Germany: the DIAS study (diabetes and social disparities).

Pediatr Diabetes 2019 Mar 25. Epub 2019 Mar 25.

Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

Objective: To evaluate the association between socioeconomic status (SES) and diabetes outcomes in German children and adolescents.

Methods: A total of 1829 subjects < 18 years old with type 1 diabetes mellitus from 13 German diabetes centers were included from June 2013 until June 2014. Data were collected within the multicenter DPV (Diabetes Prospective Follow-up) registry. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12847
Publisher Site
http://dx.doi.org/10.1111/pedi.12847DOI Listing
March 2019
5 Reads

Trends in Prevalence of Cardiovascular Risk Factors from 2002-2012 among Youth Early in the Course of Type 1 and Type 2 Diabetes. The SEARCH for Diabetes in Youth Study.

Pediatr Diabetes 2019 Mar 23. Epub 2019 Mar 23.

Department of Pediatrics, University of Washington, Seattle, WA, United States.

Background: Given diabetes is an important risk factor for cardiovascular disease (CVD), we examined temporal trends in CVD risk factors by comparing youth recently diagnosed with type 1 diabetes (T1D) and type 2 diabetes (T2D) from 2002 through 2012.

Methods: The SEARCH for Diabetes in Youth Study identified youth with diagnosed T1D (n=3954) and T2D (n=706) from 2002-2012. CVD risk factors were defined using the modified Adult Treatment Panel III criteria for metabolic syndrome: 1) hypertension; 2) HDL-cholesterol (HDL-C) ≤40mg/dL; 3) triglycerides (TG) ≥110mg/dL; and, 4) waist circumference (WC) >90th percentile. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12846DOI Listing

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes.

Pediatr Diabetes 2019 Mar 20. Epub 2019 Mar 20.

Division of Endocrinology, Diabetes, and Metabolism, University of Miami, Miami, Florida.

Background: In new onset type 1 diabetes (T1D), overall C-peptide measures such as area under the curve (AUC) C-peptide and peak C-peptide are useful for estimating the extent of β-cell dysfunction, and for assessing responses to intervention therapy. However, measures of the timing of C-peptide responsiveness could have additional value.

Objectives: We assessed the contribution of the timing of C-peptide responsiveness during oral glucose tolerance tests (OGTTs) to hemoglobin A1c (HbA1c) variation at T1D diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12845DOI Listing

The impact of free medical supplies and regular telephonic contact on glycemic control in Indian children and adolescents with type 1 diabetes.

Pediatr Diabetes 2019 Mar 12. Epub 2019 Mar 12.

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background/objective: The effect of economic assistance to underprivileged families with type 1 diabetes has never been described. Such a study is relevant as logistic and cultural factors may preclude an anticipated good outcome. The objective of the study is to determine the impact of economic and educational intervention on hemoglobin A1c (HbA1c) and diabetes knowledge. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12844
Publisher Site
http://dx.doi.org/10.1111/pedi.12844DOI Listing
March 2019
7 Reads

Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children.

Pediatr Diabetes 2019 Mar 12. Epub 2019 Mar 12.

Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon.

Background: Gain-of-function of ATP-sensitive K (K ) channels because of mutations in the genes encoding SUR1 (ABCC8) or Kir6.2 (KCNJ11) is a major cause of neonatal diabetes mellitus (NDM). Our aim is to determine molecular defects in K channels caused by ABCC8 mutations in Asian Indian children with NDM by in vitro functional studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12843DOI Listing

Prevalence of Type 1 and Type 2 Diabetes among US Pediatric Population in the MarketScan Multi-State Medicaid Database, 2002-2016.

Pediatr Diabetes 2019 Mar 12. Epub 2019 Mar 12.

Merck & Co., Inc., Kenilworth, NJ, USA.

Objectives: To estimate the prevalence of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) among U.S. Medicaid pediatric population aged <18 years 2002-2016 by age, sex and race/ethnicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12842DOI Listing

Feasibility and safety of a group physical activity program for youth with type 1 diabetes.

Pediatr Diabetes 2019 Mar 4. Epub 2019 Mar 4.

Yale University School of Nursing, West Haven, Connecticut.

Background/objective: Many adolescents with type 1 diabetes do not achieve 60 minutes of daily moderate-to-vigorous intensity physical activity (MVPA). Recognizing the importance of peer influence during adolescence, we evaluated the feasibility and safety of a group MVPA intervention for this population.

Methods: Eighteen adolescents with type 1 diabetes (age 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12841DOI Listing
March 2019
6 Reads

A novel 3' untranslated region mutation in the SLC29A3 gene associated with pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus syndrome.

Pediatr Diabetes 2019 Feb 28. Epub 2019 Feb 28.

Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Background: Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is one of the rare H syndrome diseases mainly characterized by hyperpigmentation, hypertrichosis, sensorineural hearing loss, cardiac complications, developmental delay, and diabetes mellitus (DM). Mutations in the coding regions of the SLC29A3 gene that encodes for an equilibrative nucleoside transporter (ENT3) have been reported to cause the phenotypic spectrum of the H syndrome. Disease-causing mutations in the untranslated regions (UTRs) of the SLC29A3 gene have not been previously described in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12839DOI Listing
February 2019
1 Read

Diabetic nephropathy and quality of life among youths with long-duration type 1 diabetes: A population-based cross-sectional study.

Pediatr Diabetes 2019 Feb 25. Epub 2019 Feb 25.

Institute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.

Objective: To investigate whether diabetic nephropathy (DN) is associated with lower quality of life (QOL) in youths with long-duration type 1 diabetes and whether associations differ by diabetes duration.

Methods: Overall, 1,462 youths aged 11 to 17 years with diabetes onset between 0 and 4 years of age and at least 10 years diabetes duration completed questionnaires on QOL between 2009 and 2016. Chronic generic and diabetes-specific QOL (diabetes impact and treatment scale) were assessed with three scales of the DISABKIDS instruments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12837DOI Listing
February 2019
1 Read

Associations of growth from birth to puberty with glycemic indicators at ~17.5 years: Evidence from Hong Kong's "Children of 1997" birth cohort.

Pediatr Diabetes 2019 Feb 25. Epub 2019 Feb 25.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.

Background: From an evolutionary biology perspective, where growth and reproduction trade-off against longevity, we assessed the associations of growth from birth to puberty by phase with later glycemic indicators and any differences by sex.

Methods: In the population-representative Hong Kong Chinese "Children of 1997" birth cohort (n = 8327), the relation of initial size (weight-for-age z score (WAZ) at birth, length/height-for-age z score (LAZ) at 3 months or body-mass-index-for-age z score (BAZ) at 3 months based on the World Health Organization growth standards/references) and growth at different phases (WAZ gains from 0 to 2 and 2 to 8 years, LAZ or BAZ gains from 3 months to 3 years, 3 to 8 years and 8 to 14 years) with fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) at ~17.5 years, was assessed using adjusted partial least squares regression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12838DOI Listing
February 2019
2.569 Impact Factor

Diabetes camp still matters: Relationships with diabetes-specific distress, strengths, and self-care skills.

Pediatr Diabetes 2019 May 24;20(3):353-360. Epub 2019 Mar 24.

Stanley Manne Children's Research Institute, Biostatistics Research Core, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Objective: Prior studies suggest diabetes camps improve psychosocial well-being in youth with type 1 diabetes but these studies suffer from variable levels of rigor. The present study assessed associations between camp participation and diabetes distress, perceived independence in diabetes self-care, and diabetes strengths in a large sample of children, adolescents, and their parents across 44 camps in the United States. Analyses compared viewpoints of study participants, identified moderators of change, and assessed perceived benefits of camp participation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12836DOI Listing

Effect of patient education through a social network in young patients with type 1 diabetes in a Sub-Saharan context.

Pediatr Diabetes 2019 May 7;20(3):361-365. Epub 2019 Mar 7.

Faculty of Medicine and Biomedical Sciences, Department of Pediatrics, University of Yaounde I, Yaounde, Cameroon.

Background: Patient education is essential in management of type 1 diabetes (T1D).

Objective: To evaluate the short-term impact of patient education through WhatsApp on the knowledge of the disease and glycemic control of adolescents and young adults living with T1D in a resource-limited setting.

Methods: A double arm non-randomized clinical trial was carried out in two clinics for diabetes in Cameroon, over a period of 2 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12835DOI Listing
May 2019
2 Reads

Insulin pump therapy, pre-pump hemoglobin A and metabolic improvement in children with type 1 diabetes at a tertiary Canadian children's hospital.

Pediatr Diabetes 2019 Feb 18. Epub 2019 Feb 18.

Endocrinology and Diabetes Unit, BC Children's Hospital, Vancouver, British Columbia, Canada.

Background And Objectives: Indications for insulin pump therapy (IPT) in children with type 1 diabetes (T1D) are relatively non-specific and therefore subject to provider discretion. Health professionals' perceptions of which people will have difficulty with IPT, for example, those with higher hemoglobin A (HbA ), may not be correct. This study examined the effect of IPT on HbA , and the role of pre-pump HbA on this effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12834DOI Listing
February 2019

Persistent heterogeneity in diabetes technology reimbursement for children with type 1 diabetes: The SWEET perspective.

Pediatr Diabetes 2019 Feb 17. Epub 2019 Feb 17.

Department of Medical Psychology, Hannover Medical School, Hannover, Germany.

Background: Frequent use of modern diabetes technologies increases the chance for optimal type 1 diabetes (T1D) control. Limited reimbursement influences the access of patients with T1D to these modalities and could worsen their prognosis. We aimed to describe the situation of reimbursement for insulins, glucometers, insulin pumps (CSII) and continuous glucose monitoring (CGM) for children with T1D in European countries participating in the SWEET Project and to compare data from EU countries with data from our previous study in 2009. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12833DOI Listing
February 2019
1 Read

Review of Leipzig protocol for intravenous insulin infusion in pediatric patients with type 1 diabetes during intercurrent illness and surgery.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Department of Endocrinology and Diabetology, University of Leipzig, Hospital for Children and Adolescents, Leipzig, Germany.

Objective: Continuous intravenous (IV) insulin infusion therapy minimizes blood glucose (BG) fluctuations and prevents metabolic deterioration in pediatric patients with type 1 diabetes (T1D) during intercurrent illness and surgery. However, data on the adequate fluid and insulin substitution in this situation is rare. We evaluated the effectiveness and safety of IV insulin therapy according to our local protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12830DOI Listing
February 2019
3 Reads

Characteristics of cystic fibrosis-related diabetes: Data from two different sources the European cystic fibrosis society patient registry and German/Austrian diabetes prospective follow-up registry.

Pediatr Diabetes 2019 May 7;20(3):255-262. Epub 2019 Mar 7.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany.

Background: Standardized patient registries provide a unique basis to get insight into cystic fibrosis (CF)-related diabetes (CFRD), the most common comorbidity in CF.

Methods: A total of 3853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow-up (diabetes patienten verlaufsdokumentation [DPV]) were studied. To adjust for age and sex, multivariable regression was used (SAS 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12831DOI Listing
May 2019
1 Read

Prevalence of type 2 diabetes among adolescents in Brazil: Findings from Study of Cardiovascular Risk in Adolescents (ERICA).

Pediatr Diabetes 2019 Feb 9. Epub 2019 Feb 9.

Postraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: Type 2 diabetes mellitus (T2DM) in adolescents represents a clinical challenge related to lifestyle and obesity; however, only a few data are available in developing countries. Therefore, our aim was to investigate the prevalence of T2DM and prediabetes among Brazilian adolescents, as well as to describe the cardio-metabolic profile according to the diagnosis.

Methods: This is a cross-sectional school-based multicenter study including youth aged 12 to 17 years from cities with more than 100 000 inhabitants in Brazil (n = 37 854 students). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12828DOI Listing
February 2019
2 Reads

Presentation to primary care during the prodrome of type 1 diabetes in childhood: A case-control study using record data linkage.

Pediatr Diabetes 2019 May 7;20(3):330-338. Epub 2019 Mar 7.

Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.

Objective: To evaluate primary care presentations during the prodrome (12 months prior to onset type-1 diabetes (T1D), with or without diabetic ketoacidosis [DKA]), to identify opportunities for earlier diagnosis.

Methods: This was a case-control study, linking 16 years of data from children (≤15 years) registered at diagnosis of T1D, and routinely collected primary care records in Wales (United Kingdom). Controls (without T1D) were matched on a 3:1 ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12829DOI Listing
May 2019
1 Read

Prevalence of celiac disease in a large cohort of young patients with type 1 diabetes.

Pediatr Diabetes 2019 Feb 8. Epub 2019 Feb 8.

Institute for Children with Diabetes (ICD), Conceição Children Hospital (HCC), Conceição Hospital Group (GHC), Ministry of Health, Porto Alegre, RS, Brazil.

Background: Serological screening for celiac disease (CD) allows the identification of individuals genetically predisposed, as type 1 diabetes mellitus (T1DM). However, the diagnosis is confirmed by intestinal biopsy. The aim was to determine the prevalence of immunoglobulin-A anti-tissue transglutaminase antibodies (IgA-tTG) and CD in a large cohort of young T1DM patients. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12827
Publisher Site
http://dx.doi.org/10.1111/pedi.12827DOI Listing
February 2019
7 Reads

Phenotypic variability in two siblings with monogenic diabetes due to the same ABCC8 gene mutation.

Pediatr Diabetes 2019 Feb 7. Epub 2019 Feb 7.

Paediatric Endocrinology, St George's University Hospital NHS Foundation Trust, London, UK.

ABCC8 gene mutations with different inheritance patterns have been well described to cause transient and permanent forms of neonatal diabetes with onset of hyperglycemia commonly before the age of 6 months, and rare cases between 6 and 12 months. However, recent analyses have also demonstrated ABCC8 gene mutations in patients with monogenic diabetes (maturity onset diabetes of the young, MODY), with milder clinical phenotypes and later onset of hyperglycemia. We report two siblings with diabetes mellitus due to a novel homozygous p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12826DOI Listing
February 2019

Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study.

Pediatr Diabetes 2019 May 20;20(3):286-292. Epub 2019 Feb 20.

Department of Children's Diabetology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Background/objective: The study aimed to analyze the frequency of partial remission (PR) and its association with chosen clinical and laboratory factors among pediatric patients with newly diagnosed type 1 diabetes (T1D). The long-term effect of PR on chosen parameters was also investigated.

Methods: In 194 patients (95 girls) aged 8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12824DOI Listing

Serum catestatin concentrations are decreased in obese children and adolescents.

Pediatr Diabetes 2019 Feb 4. Epub 2019 Feb 4.

Department of Pediatrics, University Hospital of Split, Split, Croatia.

Background: Catestatin is a chromogranin A-derived peptide with a wide spectrum of biological activities, such as inhibiting catecholamine release, decreasing blood pressure, stimulating histamine release, reducing beta-adrenergic stimulation and regulating oxidative stress.

Objectives: The aims of our study were to determine serum catestatin concentrations in obese children and adolescents in regard to presence or absence of MS and to evaluate the possible relations between catestatin levels and other cardiovascular risk factors.

Subjects: Ninety-two obese subjects with a BMI z score > 2, aged 10 to 18 years, and thirty-nine healthy, normal weight controls were enrolled in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12825DOI Listing
February 2019

Glibenclamide oral suspension: Suitable and effective in patients with neonatal diabetes.

Pediatr Diabetes 2019 May 21;20(3):246-254. Epub 2019 Feb 21.

Pediatric diabetes and endocrinology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background: Results of genetic have led to off-label glibenclamide treatment in patients with neonatal diabetes (NDM) because of potassium channel mutations. No pediatric form of glibenclamide was available. Glibenclamide was designated an orphan drug designation for NDM and a suspension was developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12823DOI Listing
May 2019
1 Read

Exome sequencing identifies a de novo FOXA2 variant in a patient with syndromic diabetes.

Pediatr Diabetes 2019 May 17;20(3):366-369. Epub 2019 Feb 17.

Pediatric Endocrine and Diabetes Unit, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.

Objective: When diabetes is associated with congenital malformations, without autoimmune antibodies, a genetic cause is suspected. Here, we aimed to identify a defective gene that led to diabetes.

Research Design And Methods: We performed an exome analysis of an index case and his healthy parents. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12814
Publisher Site
http://dx.doi.org/10.1111/pedi.12814DOI Listing
May 2019
10 Reads

Health care access and glycemic control in youth and young adults with type 1 and type 2 diabetes in South Carolina.

Pediatr Diabetes 2019 May 19;20(3):321-329. Epub 2019 Feb 19.

Departments of Nutrition and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Affordability and geographic accessibility are key health care access characteristics. We used data from 481 youth and young adults (YYA) with diabetes (389 type 1, 92 type 2) to understand the association between health care access and glycemic control as measured by HbA values. In multivariate models, YYA with state or federal health insurance had HbA percentage values 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456401PMC
May 2019
3 Reads

The rate of hyperglycemia and ketosis with insulin degludec-based treatment compared with insulin detemir in pediatric patients with type 1 diabetes: An analysis of data from two randomized trials.

Pediatr Diabetes 2019 May 10;20(3):314-320. Epub 2019 Feb 10.

Department of General Paediatrics, Endocrinology/Diabetology and Clinical Research, Children's Hospital Auf der Bult, Hannover, Germany.

Background: Historically, data on the rate of hyperglycemia and ketosis have not been collected in clinical trials. However, it is clinically important to assess the rate of these events in children with type 1 diabetes (T1D). This question was addressed in two pediatric trials using insulin degludec (degludec). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12821
Publisher Site
http://dx.doi.org/10.1111/pedi.12821DOI Listing
May 2019
5 Reads

Is there an optimal strategy for real-time continuous glucose monitoring in pediatrics? A 12-month French multi-center, prospective, controlled randomized trial (Start-In!).

Pediatr Diabetes 2019 May 6;20(3):304-313. Epub 2019 Feb 6.

Pediatric Endocrinology and Diabetology Department and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, CHU Robert Debré, AP-HP, Paris, France.

Aim: To compare the efficacy of three strategies for real-time continuous glucose monitoring (RT-CGM) over 12 months in children and adolescents with type 1 diabetes.

Methods: A French multicenter trial (NCT00949221) with a randomized, controlled, prospective, open, and parallel-group design was conducted. After 3 months of RT-CGM, patients were allocated to one of three groups: return to self-monitoring of blood glucose, continuous CGM (80% of the time), or discontinuous CGM (40% of the time). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12820DOI Listing
May 2019
5 Reads

Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration.

Pediatr Diabetes 2019 May 19;20(3):282-285. Epub 2019 Feb 19.

Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Aims: Residual beta-cell secretion in type 1 diabetes is commonly assessed by area-under-curve of plasma C-peptide concentration (AUC ) following mixed-meal tolerance test (MMTT). We aimed to investigate alternative measures of beta-cell responsiveness.

Methods: We analyzed data from 32 youth (age 7 to 17 years) undergoing MMTT within 6 months of type 1 diabetes diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12816DOI Listing
May 2019
5 Reads

Online education for gluten-free diet teaching: Development and usability testing of an e-learning module for children with concurrent celiac disease and type 1 diabetes.

Pediatr Diabetes 2019 May 10;20(3):293-303. Epub 2019 Feb 10.

Child Health Evaluative Sciences, SickKids Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

Background And Objective: Celiac disease (CD), the most common genetically-based food intolerance, affects 3% to 16% of children with type 1 diabetes (T1D). Treatment involves lifelong adherence to a gluten-free diet (GFD). Individualized dietary education is resource-intensive. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12815
Publisher Site
http://dx.doi.org/10.1111/pedi.12815DOI Listing
May 2019
8 Reads
2.569 Impact Factor

Genetic polymorphisms associated with pediatric-onset type 2 diabetes: A family-based transmission disequilibrium test and case-control study.

Pediatr Diabetes 2019 May 6;20(3):239-245. Epub 2019 Feb 6.

Deputy Director of Research, Mexico Children's Hospital Federico Gómez, Mexico City, Mexico.

Background And Objective: Genetics play a very strong role in the development of pediatric-onset type 2 diabetes (T2D); however, little information exists about specific common single nucleotide polymorphisms (SNPs) associated with T2D in this age group. The aim of the study was to analyze the association and parental transmission of 64 obesity-related SNPs with pediatric-onset T2D in Mexican families.

Methods: A total of 57 pedigrees containing 171 probands with pediatric-onset T2D and 119 unrelated controls older than 18 years were included. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12818
Publisher Site
http://dx.doi.org/10.1111/pedi.12818DOI Listing
May 2019
2 Reads
2.569 Impact Factor

Translating glycated hemoglobin A1c into time spent in glucose target range: A multicenter study.

Pediatr Diabetes 2019 May 31;20(3):339-344. Epub 2019 Jan 31.

School of Medical Sciences, Örebro University, Örebro, Sweden.

Background: Approximately 90% of children and adolescents with type 1 diabetes in Sweden use continuous glucose monitoring (CGM), either as real-time CGM or intermittently scanned CGM to monitor their glucose levels. Time in target range (TIT) is an easily understandable metric for assessing glycemic control.

Objective: The aim of this study was to examine the relation between TIT and hemoglobin A1c (HbA1c). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12817
Publisher Site
http://dx.doi.org/10.1111/pedi.12817DOI Listing
May 2019
11 Reads

The effect of attention deficit/hyperactivity disorder and other psychiatric disorders on the treatment of pediatric diabetes mellitus.

Pediatr Diabetes 2019 May 31;20(3):345-352. Epub 2019 Jan 31.

Department of Pediatric Endocrinology and Diabetes, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

Objective: Psychiatric diagnoses of patients with type 1 diabetes mellitus (T1DM), the severity of attention deficit/hyperactivity disorder (ADHD) symptoms of the patients and their primary caregivers, and the effects of these factors on treatment were investigated.

Methods: Sixty-one patients with T1DM were included in the study along with their parents. Psychiatric diagnoses of the patients were determined using a semistructured psychiatric interview, and their depression and ADHD symptom severities were evaluated with self-report scales. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pedi.12819
Publisher Site
http://dx.doi.org/10.1111/pedi.12819DOI Listing
May 2019
12 Reads

Characterization of proinsulin-specific regulatory T cells in type 1 diabetes at different ages of onset.

Pediatr Diabetes 2019 May 27;20(3):271-281. Epub 2019 Jan 27.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background And Objectives: Regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens. Defects in the frequency and function of polyclonal Tregs have been reported in type 1 diabetes (T1D). However, characteristics of proinsulin (PI)-specific Tregs in human T1D have not yet been explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12813DOI Listing

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

Pediatr Diabetes 2019 May 29;20(3):263-270. Epub 2019 Jan 29.

Department of Pediatrics, University of Florida, Gainesville, Florida.

Objective: The capacity to precisely predict progression to type 1 diabetes (T1D) in young children over a short time span is an unmet need. We sought to develop a risk algorithm to predict progression in children with high-risk human leukocyte antigen (HLA) genes followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study.

Methods: Logistic regression and 4-fold cross-validation examined 38 candidate predictors of risk from clinical, immunologic, metabolic, and genetic data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456374PMC
May 2019
5 Reads

Earlier puberty in boys with type 1 diabetes mellitus compared to a simultaneously recruited group of control adolescents.

Pediatr Diabetes 2019 Mar 8;20(2):197-201. Epub 2019 Jan 8.

Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile.

Background: Recent studies have suggested that there is an earlier age of onset of puberty in healthy boys. However, no study has determined the age of pubertal development in boys with type 1 diabetes (T1D) and compared the results with a simultaneously recruited group of healthy children.

Objective: The aim of this study was to evaluate the age of pubertal events in boys with TD1 and determine whether the duration of diabetes, metabolic control or insulin dose are associated with the age of puberty in boys with T1D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12811DOI Listing

Exploring the role of motivational interviewing in adolescent patient-provider communication about type 1 diabetes.

Pediatr Diabetes 2019 Mar 8;20(2):217-225. Epub 2019 Jan 8.

Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.

Objective: Adolescents with type 1 diabetes (T1D) frequently experience deterioration in glycemic control. Providers have unique opportunities to address diabetes self-management, yet little is known about the most effective way to communicate with adolescents. This investigation used a motivational interviewing (MI) framework to characterize naturally-occurring adolescent patient-provider communication in medical encounters and examined relations between adolescent patient-provider communication and (a) T1D self-management and (b) glycemic control (hemoglobin A1c [HbA1c]). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12810DOI Listing

An improved clinical model to predict stimulated C-peptide in children with recent-onset type 1 diabetes.

Pediatr Diabetes 2019 Mar 8;20(2):166-171. Epub 2019 Jan 8.

The University of Queensland, Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.

Background: Stimulated C-peptide measurement after a mixed meal tolerance test (MMTT) is the accepted gold standard for assessing residual beta-cell function in type 1 diabetes (T1D); however, this approach is impractical outside of clinical trials.

Objective: To develop an improved estimate of residual beta-cell function in children with T1D using commonly measured clinical variables.

Subjects/methods: A clinical model to predict 90-minute MMTT stimulated C-peptide in children with recent-onset T1D was developed from the combined AbATE, START, and TIDAL placebo subjects (n = 46) 6 months post-recruitment using multiple linear regression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12808DOI Listing

Diabetic ketoacidosis at diagnosis of type 1 diabetes and glycemic control over time: The SEARCH for diabetes in youth study.

Pediatr Diabetes 2019 Mar 27;20(2):172-179. Epub 2018 Dec 27.

Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Background: The diagnosis of type 1 diabetes (T1D) in youth is often associated with diabetic ketoacidosis (DKA). We aimed to evaluate if the presence of DKA at diagnosis of T1D is associated with less favorable hemoglobin A1c (HbA1c) trajectories over time.

Methods: The SEARCH for Diabetes in Youth study of 1396 youth aged <20 years with newly diagnosed T1D were followed for up to 13 (median 8 [interquartile range or IQR 6-9]) years after diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361710PMC
March 2019
4 Reads

Efficacy of mindfulness-based stress reduction in emerging adults with poorly controlled, type 1 diabetes: A pilot randomized controlled trial.

Pediatr Diabetes 2019 Mar 27;20(2):226-234. Epub 2018 Dec 27.

Center for Mind-Body Research, Johns Hopkins University, Baltimore, Maryland.

Background/objective: The negative effects of stress on persons with type 1 diabetes (T1D) are well-established, but effective interventions to reduce stress among emerging adults with T1D are limited. The study objective was to conduct a pilot randomized controlled trial (RCT) to obtain preliminary data on the efficacy of mindfulness-based stress reduction (MBSR) to reduce stress and improve diabetes health outcomes in a population of high-risk, urban emerging adults with poorly controlled diabetes.

Methods: Forty-eight participants aged 16 to 20 years of age with T1D (mean duration = 8 years) were randomly assigned to one of three conditions: MSBR, cognitive-behavioral stress management (CBSM), or a diabetes support group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12807DOI Listing
March 2019
1 Read