1,662 results match your criteria Pediatric Diabetes [Journal]


Diabetes Camp Still Matters: Relationships with Diabetes-Specific Distress, Strengths, and Self-Care Skills.

Pediatr Diabetes 2019 Feb 21. Epub 2019 Feb 21.

Stanley Manne Children's Research Institute, Biostatistics Research Core, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Objective: Prior studies suggest diabetes camps improve psychosocial well-being in youth with type 1 diabetes but these studies suffer from variable levels of rigor. The current study assessed associations between camp participation and diabetes distress, perceived independence in diabetes self-care, and diabetes strengths in a large sample of children, adolescents, and their parents across 42 camps in the United States. Analyses compared viewpoints of study participants, identified moderators of change, and assessed perceived benefits of camp participation. Read More

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http://dx.doi.org/10.1111/pedi.12836DOI Listing
February 2019

Effect of patient education through a social network in young patients with type I diabetes in a Sub-Saharan context.

Pediatr Diabetes 2019 Feb 18. Epub 2019 Feb 18.

University of Yaounde.

Background: Patient education is essential in management of type I diabetes.

Objective: To evaluate the short-term impact of patient education through WhatsApp on the knowledge of the disease and glycemic control of adolescents and young adults living with Type 1 diabetes in a resource-limited setting.

Methods: A double arm non-randomized clinical trial was carried out in two clinics for diabetes in Cameroon, over a period of two months. Read More

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http://dx.doi.org/10.1111/pedi.12835DOI Listing
February 2019

Insulin pump therapy, pre-pump HbA and metabolic improvement in children with type 1 diabetes at a tertiary Canadian children's hospital.

Pediatr Diabetes 2019 Feb 18. Epub 2019 Feb 18.

Endocrinology & Diabetes Unit, BC Children's Hospital, Vancouver, Canada.

Background And Objectives: Indications for insulin pump therapy (IPT) in children with type 1 diabetes (T1D) are relatively non-specific and therefore subject to provider discretion. Health professionals' perceptions of which people will have difficulty with IPT, e.g. Read More

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http://dx.doi.org/10.1111/pedi.12834DOI Listing
February 2019

Persistent heterogeneity in diabetes technology reimbursement for children with Type 1 Diabetes: The SWEET perspective.

Pediatr Diabetes 2019 Feb 17. Epub 2019 Feb 17.

Department of Medical Psychology, Hannover Medical School, Hannover, Germany.

Background: Frequent use of modern diabetes technologies increases the chance for optimal type 1 diabetes (T1D) control. Limited reimbursement influences the access of patients with T1D to these modalities and could worsen their prognosis. We aimed to describe the situation of reimbursement for insulins, glucometers, insulin pumps (CSII) and continuous glucose monitoring (CGM) for children with T1D in European countries participating in the SWEET Project and to compare data from EU countries with data from our previous study in 2009. Read More

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http://dx.doi.org/10.1111/pedi.12833DOI Listing
February 2019

Review of Leipzig protocol for intravenous insulin infusion in pediatric patients with type 1 diabetes during intercurrent illness and surgery.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Department of Endocrinology and Diabetology, University of Leipzig, Hospital for Children and Adolescents, 04103 Leipzig, Sachsen, Germany.

Objective: Continuous intravenous (IV) insulin infusion therapy minimizes blood glucose (BG) fluctuations and prevents metabolic deterioration in pediatric patients with type 1 diabetes (T1D) during intercurrent illness and surgery. However, data on the adequate fluid and insulin substitution in this situation is rare. We evaluated the effectiveness and safety of IV insulin therapy according to our local protocol. Read More

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http://dx.doi.org/10.1111/pedi.12830DOI Listing
February 2019
1 Read

Characteristics of CF-related Diabetes: Data from Two Different Sources the ECFS Patient Registry and the DPV Registry.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, 89081 Ulm, Germany.

Background: Standardized patient registries provide a unique basis to get insight into cystic fibrosis-related diabetes (CFRD), the most common comorbidity in cystic fibrosis.

Methods: 3,853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow-up (DPV) were studied. To adjust for age and sex, multivariable regression was used (SAS 9. Read More

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http://dx.doi.org/10.1111/pedi.12831DOI Listing
February 2019
1 Read

Prevalence of type 2 diabetes among adolescents in Brazil: findings from Study of Cardiovascular Risk in Adolescents (ERICA).

Pediatr Diabetes 2019 Feb 9. Epub 2019 Feb 9.

Post-graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: Type 2 diabetes (T2DM) in adolescents represents a clinical challenge related to lifestyle and obesity; however, only a few data are available in developing countries. Therefore, our aim was to investigate the prevalence of T2DM and prediabetes among Brazilian adolescents, as well as to describe the cardio-metabolic profile according to the diagnosis.

Methods: This is a cross-sectional school-based multicenter study including youth aged 12-17 years from cities with more than 100,000 inhabitants in Brazil (n=37,854 students). Read More

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http://dx.doi.org/10.1111/pedi.12828DOI Listing
February 2019
1 Read

Presentation to primary care during the prodrome of Type 1 diabetes in childhood: a case-control study using record data linkage.

Pediatr Diabetes 2019 Feb 9. Epub 2019 Feb 9.

Division of Population Medicine, School of Medicine, Cardiff University, Cardiff.

Objective: To evaluate primary care presentations during the prodrome (12 months prior to onset-Type 1 diabetes, with or without DKA), to identify opportunities for earlier diagnosis.

Methods: This was a case-control study, linking 16 years of data from children (≤15 years) registered at diagnosis of Type 1 diabetes, and routinely collected primary care records in Wales (UK). Controls (without Type 1 diabetes) were matched on a 3:1 ratio. Read More

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http://dx.doi.org/10.1111/pedi.12829DOI Listing
February 2019
1 Read

Prevalence of celiac disease in a large cohort of young patients with type 1 diabetes.

Pediatr Diabetes 2019 Feb 8. Epub 2019 Feb 8.

Instituto da Criança com Diabetes, Grupo Hospitalar Conceição - Ministério da Saúde.

Background: Serological screening for celiac disease (CD) allows the identification of individuals genetically predisposed, as type 1 diabetes mellitus (T1DM). However, the diagnosis is confirmed by intestinal biopsy. The aim was to determine the prevalence of immunoglobulin-A anti-tissue transglutaminase antibodies (IgA-tTG) and CD in a large cohort of young T1DM patients. Read More

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http://doi.wiley.com/10.1111/pedi.12827
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http://dx.doi.org/10.1111/pedi.12827DOI Listing
February 2019
3 Reads

Phenotypic variability in two siblings with monogenic diabetes due to the same ABCC8 gene mutation.

Pediatr Diabetes 2019 Feb 7. Epub 2019 Feb 7.

St George's University Hospital NHS Foundation Trust, Paediatric Endocrinology, London, (UK).

Background: ABCC8 gene mutations with different inheritance patterns have been well described to cause transient and permanent forms of neonatal diabetes with onset of hyperglycaemia commonly before the age of 6 months, and rare cases between 6 and 12 months. However, recent analyses have also demonstrated ABCC8 gene mutations in patients with monogenic diabetes (maturity onset diabetes of the young, MODY), with milder clinical phenotypes and later onset of hyperglycaemia.

Clinical Cases: We report 2 siblings with diabetes mellitus due to a novel homozygous p. Read More

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http://dx.doi.org/10.1111/pedi.12826DOI Listing
February 2019

Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study.

Pediatr Diabetes 2019 Feb 3. Epub 2019 Feb 3.

Department of Children's Diabetology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Background/objective: The study aimed to analyze the frequency of partial remission (PR) and its association with chosen clinical and laboratory factors among pediatric patients with newly diagnosed type 1 diabetes (T1D). The long-term effect of PR on chosen parameters was also investigated.

Methods: In 194 patients (95 girls) aged 8. Read More

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http://dx.doi.org/10.1111/pedi.12824DOI Listing
February 2019

Serum catestatin concentrations are decreased in obese children and adolescents.

Pediatr Diabetes 2019 Feb 4. Epub 2019 Feb 4.

Department of Pediatrics, University Hospital of Split, Split, Croatia.

Background: Catestatin is a chromogranin A-derived peptide with a wide spectrum of biological activities, such as inhibiting catecholamine release, decreasing blood pressure, stimulating histamine release, reducing beta-adrenergic stimulation and regulating oxidative stress.

Objectives: The aims of our study were to determine serum catestatin concentrations in obese children and adolescents in regard to presence or absence of MS and to evaluate the possible relations between catestatin levels and other cardiovascular risk factors.

Subjects: Ninety-two obese subjects with a BMI z score > 2, aged 10 to 18 years, and thirty-nine healthy, normal weight controls were enrolled in the study. Read More

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http://dx.doi.org/10.1111/pedi.12825DOI Listing
February 2019

Glibenclamide oral suspension: Suitable and effective in patients with neonatal diabetes.

Pediatr Diabetes 2019 Jan 26. Epub 2019 Jan 26.

Pediatric diabetes and endocrinology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background: Results of genetic have led to off-label glibenclamide treatment in patients with neonatal diabetes (NDM) because of potassium channel mutations. No pediatric form of glibenclamide was available. Glibenclamide was designated an orphan drug designation for NDM and a suspension was developed. Read More

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http://dx.doi.org/10.1111/pedi.12823DOI Listing
January 2019
1 Read

Exome sequencing identifies a de novo FOXA2 variant in a patient with syndromic diabetes.

Pediatr Diabetes 2019 Jan 26. Epub 2019 Jan 26.

Pediatric Endocrine and Diabetes Unit, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.

Objective: When diabetes is associated with congenital malformations, without autoimmune antibodies, a genetic cause is suspected. Here, we aimed to identify a defective gene that led to diabetes.

Research Design And Methods: We performed an exome analysis of an index case and his healthy parents. Read More

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http://doi.wiley.com/10.1111/pedi.12814
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http://dx.doi.org/10.1111/pedi.12814DOI Listing
January 2019
4 Reads

Health care access and glycemic control in youth and young adults with type 1 and type 2 diabetes in South Carolina.

Pediatr Diabetes 2019 Jan 22. Epub 2019 Jan 22.

Departments of Nutrition and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Affordability and geographic accessibility are key health care access characteristics. We used data from 481 youth and young adults (YYA) with diabetes (389 type 1, 92 type 2) to understand the association between health care access and glycemic control as measured by HbA values. In multivariate models, YYA with state or federal health insurance had HbA percentage values 0. Read More

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http://dx.doi.org/10.1111/pedi.12822DOI Listing
January 2019
2 Reads

The rate of hyperglycemia and ketosis with insulin degludec-based treatment compared with insulin detemir in pediatric patients with type 1 diabetes: An analysis of data from two randomized trials.

Pediatr Diabetes 2019 Jan 22. Epub 2019 Jan 22.

Department of General Paediatrics, Endocrinology/Diabetology and Clinical Research, Children's Hospital Auf der Bult, Hannover, Germany.

Background: Historically, data on the rate of hyperglycemia and ketosis have not been collected in clinical trials. However, it is clinically important to assess the rate of these events in children with type 1 diabetes (T1D). This question was addressed in two pediatric trials using insulin degludec (degludec). Read More

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http://doi.wiley.com/10.1111/pedi.12821
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http://dx.doi.org/10.1111/pedi.12821DOI Listing
January 2019
5 Reads

Is there an optimal strategy for real-time continuous glucose monitoring in pediatrics? A 12-month French multi-center, prospective, controlled randomized trial (Start-In!).

Pediatr Diabetes 2019 Jan 20. Epub 2019 Jan 20.

Pediatric Endocrinology and Diabetology Department and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, CHU Robert Debré, AP-HP, Paris, France.

Aim: To compare the efficacy of three strategies for real-time continuous glucose monitoring (RT-CGM) over 12 months in children and adolescents with type 1 diabetes.

Methods: A French multicenter trial (NCT00949221) with a randomized, controlled, prospective, open, and parallel-group design was conducted. After 3 months of RT-CGM, patients were allocated to one of three groups: return to self-monitoring of blood glucose, continuous CGM (80% of the time), or discontinuous CGM (40% of the time). Read More

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http://dx.doi.org/10.1111/pedi.12820DOI Listing
January 2019
3 Reads

Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration.

Pediatr Diabetes 2019 Jan 16. Epub 2019 Jan 16.

Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Aims: Residual beta-cell secretion in type 1 diabetes is commonly assessed by area-under-curve of plasma C-peptide concentration (AUC ) following mixed-meal tolerance test (MMTT). We aimed to investigate alternative measures of beta-cell responsiveness.

Methods: We analyzed data from 32 youth (age 7 to 17 years) undergoing MMTT within 6 months of type 1 diabetes diagnosis. Read More

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http://dx.doi.org/10.1111/pedi.12816DOI Listing
January 2019

Online education for gluten-free diet teaching: Development and usability testing of an e-learning module for children with concurrent celiac disease and type 1 diabetes.

Pediatr Diabetes 2019 Jan 16. Epub 2019 Jan 16.

Child Health Evaluative Sciences, SickKids Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

Background And Objective: Celiac disease (CD), the most common genetically-based food intolerance, affects 3% to 16% of children with type 1 diabetes (T1D). Treatment involves lifelong adherence to a gluten-free diet (GFD). Individualized dietary education is resource-intensive. Read More

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http://doi.wiley.com/10.1111/pedi.12815
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http://dx.doi.org/10.1111/pedi.12815DOI Listing
January 2019
3 Reads
2.569 Impact Factor

Genetic polymorphisms associated with pediatric-onset type 2 diabetes: A family-based transmission disequilibrium test and case-control study.

Pediatr Diabetes 2019 Jan 16. Epub 2019 Jan 16.

Deputy Director of Research, Mexico Children's Hospital Federico Gómez, Mexico City, Mexico.

Background And Objective: Genetics play a very strong role in the development of pediatric-onset type 2 diabetes (T2D); however, little information exists about specific common single nucleotide polymorphisms (SNPs) associated with T2D in this age group. The aim of the study was to analyze the association and parental transmission of 64 obesity-related SNPs with pediatric-onset T2D in Mexican families.

Methods: A total of 57 pedigrees containing 171 probands with pediatric-onset T2D and 119 unrelated controls older than 18 years were included. Read More

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http://dx.doi.org/10.1111/pedi.12818DOI Listing
January 2019
2.569 Impact Factor

Translating glycated hemoglobin A1c into time spent in glucose target range: A multicenter study.

Pediatr Diabetes 2019 Jan 16. Epub 2019 Jan 16.

School of Medical Sciences, Örebro University, Örebro, Sweden.

Background: Approximately 90% of children and adolescents with type 1 diabetes in Sweden use continuous glucose monitoring (CGM), either as real-time CGM or intermittently scanned CGM to monitor their glucose levels. Time in target range (TIT) is an easily understandable metric for assessing glycemic control.

Objective: The aim of this study was to examine the relation between TIT and hemoglobin A1c (HbA1c). Read More

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http://doi.wiley.com/10.1111/pedi.12817
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http://dx.doi.org/10.1111/pedi.12817DOI Listing
January 2019
7 Reads

The effect of attention deficit/hyperactivity disorder and other psychiatric disorders on the treatment of pediatric diabetes mellitus.

Pediatr Diabetes 2019 Jan 16. Epub 2019 Jan 16.

Department of Pediatric Endocrinology and Diabetes, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

Objective: Psychiatric diagnoses of patients with type 1 diabetes mellitus (T1DM), the severity of attention deficit/hyperactivity disorder (ADHD) symptoms of the patients and their primary caregivers, and the effects of these factors on treatment were investigated.

Methods: Sixty-one patients with T1DM were included in the study along with their parents. Psychiatric diagnoses of the patients were determined using a semistructured psychiatric interview, and their depression and ADHD symptom severities were evaluated with self-report scales. Read More

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http://doi.wiley.com/10.1111/pedi.12819
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http://dx.doi.org/10.1111/pedi.12819DOI Listing
January 2019
5 Reads

Characterization of proinsulin-specific regulatory T cells in type 1 diabetes at different ages of onset.

Pediatr Diabetes 2019 Jan 11. Epub 2019 Jan 11.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background And Objectives: Regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens. Defects in the frequency and function of polyclonal Tregs have been reported in type 1 diabetes (T1D). However, characteristics of proinsulin (PI)-specific Tregs in human T1D have not yet been explored. Read More

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http://dx.doi.org/10.1111/pedi.12813DOI Listing
January 2019

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

Pediatr Diabetes 2019 Jan 10. Epub 2019 Jan 10.

Department of Pediatrics, University of Florida, Gainesville, Florida.

Objective: The capacity to precisely predict progression to type 1 diabetes (T1D) in young children over a short time span is an unmet need. We sought to develop a risk algorithm to predict progression in children with high-risk human leukocyte antigen (HLA) genes followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study.

Methods: Logistic regression and 4-fold cross-validation examined 38 candidate predictors of risk from clinical, immunologic, metabolic, and genetic data. Read More

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http://dx.doi.org/10.1111/pedi.12812DOI Listing
January 2019
2 Reads

Earlier puberty in boys with type 1 diabetes mellitus compared to a simultaneously recruited group of control adolescents.

Pediatr Diabetes 2019 Mar 8;20(2):197-201. Epub 2019 Jan 8.

Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile.

Background: Recent studies have suggested that there is an earlier age of onset of puberty in healthy boys. However, no study has determined the age of pubertal development in boys with type 1 diabetes (T1D) and compared the results with a simultaneously recruited group of healthy children.

Objective: The aim of this study was to evaluate the age of pubertal events in boys with TD1 and determine whether the duration of diabetes, metabolic control or insulin dose are associated with the age of puberty in boys with T1D. Read More

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http://dx.doi.org/10.1111/pedi.12811DOI Listing

Exploring the role of motivational interviewing in adolescent patient-provider communication about type 1 diabetes.

Pediatr Diabetes 2019 Mar 8;20(2):217-225. Epub 2019 Jan 8.

Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia.

Objective: Adolescents with type 1 diabetes (T1D) frequently experience deterioration in glycemic control. Providers have unique opportunities to address diabetes self-management, yet little is known about the most effective way to communicate with adolescents. This investigation used a motivational interviewing (MI) framework to characterize naturally-occurring adolescent patient-provider communication in medical encounters and examined relations between adolescent patient-provider communication and (a) T1D self-management and (b) glycemic control (hemoglobin A1c [HbA1c]). Read More

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http://dx.doi.org/10.1111/pedi.12810DOI Listing

An improved clinical model to predict stimulated C-peptide in children with recent-onset type 1 diabetes.

Pediatr Diabetes 2019 Mar 8;20(2):166-171. Epub 2019 Jan 8.

The University of Queensland, Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.

Background: Stimulated C-peptide measurement after a mixed meal tolerance test (MMTT) is the accepted gold standard for assessing residual beta-cell function in type 1 diabetes (T1D); however, this approach is impractical outside of clinical trials.

Objective: To develop an improved estimate of residual beta-cell function in children with T1D using commonly measured clinical variables.

Subjects/methods: A clinical model to predict 90-minute MMTT stimulated C-peptide in children with recent-onset T1D was developed from the combined AbATE, START, and TIDAL placebo subjects (n = 46) 6 months post-recruitment using multiple linear regression. Read More

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http://dx.doi.org/10.1111/pedi.12808DOI Listing

Diabetic ketoacidosis at diagnosis of type 1 diabetes and glycemic control over time: The SEARCH for diabetes in youth study.

Pediatr Diabetes 2019 Mar 27;20(2):172-179. Epub 2018 Dec 27.

Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Background: The diagnosis of type 1 diabetes (T1D) in youth is often associated with diabetic ketoacidosis (DKA). We aimed to evaluate if the presence of DKA at diagnosis of T1D is associated with less favorable hemoglobin A1c (HbA1c) trajectories over time.

Methods: The SEARCH for Diabetes in Youth study of 1396 youth aged <20 years with newly diagnosed T1D were followed for up to 13 (median 8 [interquartile range or IQR 6-9]) years after diagnosis. Read More

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http://dx.doi.org/10.1111/pedi.12809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361710PMC
March 2019
3 Reads

Efficacy of mindfulness-based stress reduction in emerging adults with poorly controlled, type 1 diabetes: A pilot randomized controlled trial.

Pediatr Diabetes 2019 Mar 27;20(2):226-234. Epub 2018 Dec 27.

Center for Mind-Body Research, Johns Hopkins University, Baltimore, Maryland.

Background/objective: The negative effects of stress on persons with type 1 diabetes (T1D) are well-established, but effective interventions to reduce stress among emerging adults with T1D are limited. The study objective was to conduct a pilot randomized controlled trial (RCT) to obtain preliminary data on the efficacy of mindfulness-based stress reduction (MBSR) to reduce stress and improve diabetes health outcomes in a population of high-risk, urban emerging adults with poorly controlled diabetes.

Methods: Forty-eight participants aged 16 to 20 years of age with T1D (mean duration = 8 years) were randomly assigned to one of three conditions: MSBR, cognitive-behavioral stress management (CBSM), or a diabetes support group. Read More

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http://dx.doi.org/10.1111/pedi.12807DOI Listing
March 2019
1 Read

Insulin function in obese children within the low and high ranges of impaired fasting glycemia.

Pediatr Diabetes 2019 Mar 27;20(2):160-165. Epub 2018 Dec 27.

Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden.

Background/objective: Impaired fasting glycemia (IFG) reflects an intermediate hyperglycemia in the fasting state. Which fasting glucose level that actually is associated with impaired insulin-glucose homeostasis in children and adolescents with obesity is unknown. The aim of this study was to investigate how insulin and glucose homeostasis in children and adolescents with obesity in Sweden varies within different fasting glucose levels in the non-diabetic range. Read More

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http://dx.doi.org/10.1111/pedi.12804DOI Listing
March 2019
1 Read

Dysglycemia among youth with type 1 diabetes and suboptimal glycemic control in the Flexible Lifestyle Empowering Change trial.

Pediatr Diabetes 2019 Mar 21;20(2):180-188. Epub 2019 Jan 21.

Department of Pediatrics, School of Medicine, Stanford University, Stanford, California.

Objective: To examine the prevalence and correlates of non-severe hypoglycemia among adolescents with type 1 diabetes and suboptimal glycemic control, an understudied topic in this group.

Methods: Seven days of blinded continuous glucose monitor data were analyzed in 233 adolescents at baseline of the Flexible Lifestyle Empowering Change trial (13-16 years, type 1 diabetes duration >1 year, and hemoglobin A1c [HbA1c] 8-13% [64-119 mmol]). Incidence of clinical hypoglycemia (54-69 mg/dL) and clinically serious hypoglycemia (<54 mg/dL) was defined as number of episodes ≥15 minutes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12805
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http://dx.doi.org/10.1111/pedi.12805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367932PMC
March 2019
2 Reads

Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity.

Pediatr Diabetes 2019 Mar 27;20(2):154-159. Epub 2018 Dec 27.

Section on Ethnicity and Health, Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland.

Background: During an oral glucose tolerance test (OGTT), morphological features of the glucose curve (monophasic curve, glucose peak >30 minutes and 1-hour glucose ≥ 155 mg/dL) maybe associated with higher prediabetes risk, but their reproducibility and predictive ability in adolescents with obesity are unknown.

Methods: Nondiabetic adolescent girls with obesity underwent a multiple-sample OGTT at baseline (n = 93), 6 weeks (n = 83), and 1 year (n = 72). Short-term reproducibility (baseline to 6 weeks) and the predictive ability for prediabetes (baseline to 1 year) for each feature were compared with standard fasting and 2-hour OGTT diagnostic criteria. Read More

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http://dx.doi.org/10.1111/pedi.12803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361688PMC
March 2019
3 Reads

Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study.

Pediatr Diabetes 2019 Feb 13;20(1):23-31. Epub 2018 Dec 13.

Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain.

Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents.

Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17. Read More

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http://dx.doi.org/10.1111/pedi.12802DOI Listing
February 2019
7 Reads

Levels of type 1 diabetes care in children and adolescents for countries at varying resource levels.

Pediatr Diabetes 2019 Feb 10;20(1):93-98. Epub 2018 Dec 10.

Life for a Child Program, Sydney, New South Wales, Australia.

Optimal care for children and adolescents with type 1 diabetes is well described in guidelines, such as those of the International Society for Pediatric and Adolescent Diabetes. High-income countries can usually provide this, but the cost of this care is generally prohibitive for lower-income countries. Indeed, in most of these countries, very little care is provided by government health systems, resulting in high mortality, and high complications rates in those who do survive. Read More

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http://dx.doi.org/10.1111/pedi.12801DOI Listing
February 2019
5 Reads

The influence of cardiorespiratory fitness on clustered cardiovascular disease risk factors and the mediator role of body mass index in youth: The UP&DOWN Study.

Pediatr Diabetes 2019 Feb 10;20(1):32-40. Epub 2018 Dec 10.

Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Puerto Real, Spain.

Background: The combined effect of cardiorespiratory fitness (CRF) and body mass index (BMI) on cardiovascular disease (CVD) risk in young people remains to be fully determined. We examined the individual and combined associations of CRF and BMI with clustered CVD risk factors, and the mediator role of BMI in the association between CRF and clustered CVD risk factors in children and adolescents.

Methods: 237 children (111 girls) and 260 adolescents (120 girls) were included in this cross-sectional study. Read More

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http://dx.doi.org/10.1111/pedi.12800DOI Listing
February 2019
2.569 Impact Factor

Non-alcoholic fatty liver disease in pediatric type 2 diabetes: Metabolic and histologic characteristics in 38 subjects.

Pediatr Diabetes 2019 Feb 9;20(1):41-47. Epub 2018 Dec 9.

Pediatric Gastroenterology, University of California San Diego and Rady Children's Hospital San Diego, San Diego, California.

Background: Obesity and type 2 diabetes (T2D) is risk factors for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In children with T2D and liver biopsies, we investigated correlations between NAFLD/NASH and transaminase activity, A1c, lipids, and histologic changes in repeat biopsies.

Methods: Liver histology of children with T2D was evaluated using the NASH CRN scoring system and NAFLD Activity Score (NAS). Read More

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http://dx.doi.org/10.1111/pedi.12798DOI Listing
February 2019
12 Reads

Individual glucose responses to prolonged moderate intensity aerobic exercise in adolescents with type 1 diabetes: The higher they start, the harder they fall.

Pediatr Diabetes 2019 Feb 13;20(1):99-106. Epub 2018 Dec 13.

Jaeb Center for Health Research, Tampa, Florida.

Objective: To evaluate the pattern of change in blood glucose concentrations and hypoglycemia risk in response to prolonged aerobic exercise in adolescents with type 1 diabetes (T1D) that had a wide range in pre-exercise blood glucose concentrations.

Methods: Individual blood glucose responses to prolonged (~60 minutes) moderate-intensity exercise were profiled in 120 youth with T1D.

Results: The mean pre-exercise blood glucose concentration was 178 ± 66 mg/dL, ranging from 69 to 396 mg/dL, while the mean change in glucose during exercise was -76 ± 55 mg/dL (mean ± SD), ranging from +83 to -257 mg/dL. Read More

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http://dx.doi.org/10.1111/pedi.12799DOI Listing
February 2019
8 Reads

Sleep and type 1 diabetes in children and adolescents: Proposed theoretical model and clinical implications.

Pediatr Diabetes 2019 Feb 4;20(1):78-85. Epub 2018 Dec 4.

Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas.

Youth with type 1 diabetes mellitus (T1D) experience more sleep disturbances and shorter sleep durations compared to their healthy peers. Researchers have now uncovered the negative mental health and physical health outcomes associated with poor sleep in youth with T1D. The field of T1D sleep research currently operates under the broad notion that sleep behaviors impact treatment adherence, which ultimately lead to worse long-term health outcomes. Read More

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http://doi.wiley.com/10.1111/pedi.12797
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http://dx.doi.org/10.1111/pedi.12797DOI Listing
February 2019
9 Reads

Fluid treatment for children with diabetic ketoacidosis: How do the results of the pediatric emergency care applied research network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial change our perspective?

Pediatr Diabetes 2019 Feb 4;20(1):10-14. Epub 2018 Dec 4.

Department of Pediatrics, University of California Davis Health, University of California Davis, School of Medicine, Sacramento, California.

The optimal fluid treatment protocol for children with diabetic ketoacidosis (DKA) has long been a subject of controversy. Until recently, there was no high-quality evidence from randomized clinical trials to support an optimal guideline, and recommendations were mainly based on theoretical considerations. As a consequence, fluid treatment protocols for children with DKA vary between institutions (and countries). Read More

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http://dx.doi.org/10.1111/pedi.12795DOI Listing
February 2019
6 Reads

Choosing an accurate outcome metric for pediatric obesity care.

Pediatr Diabetes 2019 Mar 18;20(2):152-153. Epub 2018 Dec 18.

Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1111/pedi.12796DOI Listing

Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study.

Pediatr Diabetes 2019 Feb 9;20(1):86-92. Epub 2018 Dec 9.

Department of Epidemiology, University of Colorado Denver, Colorado School of Public Health, Aurora, Colorado.

Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring.

Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Read More

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http://doi.wiley.com/10.1111/pedi.12794
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http://dx.doi.org/10.1111/pedi.12794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341488PMC
February 2019
11 Reads

Optimal predictive low glucose management settings during physical exercise in adolescents with type 1 diabetes.

Pediatr Diabetes 2019 Feb 22;20(1):107-112. Epub 2018 Nov 22.

Division of Pediatrics, ASST Cremona, "Ospedale Maggiore di Cremona", Cremona, Italy.

Objectives: To assess the optimal setting of the predictive low glucose management (PLGM) algorithm for preventing exercise-induced hypoglycemia in adolescents with type 1 diabetes.

Methods: Thirty-four adolescents, 15 to 20 years, wearing PLGM system, were followed during 3 days exercise during a diabetes camp. PLGM threshold was set at 70 mg/dL between 8 am and 10 pm and 90 mg/dL during 10 pm and 8 am Adolescents were divided into group A and B, with PLGM threshold at 90 and 70 mg/dL, respectively, during exercise. Read More

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http://doi.wiley.com/10.1111/pedi.12792
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http://dx.doi.org/10.1111/pedi.12792DOI Listing
February 2019
4 Reads

Evaluation of continuous glucose monitoring system for detection of alterations in glucose homeostasis in pediatric patients with β-thalassemia major.

Pediatr Diabetes 2019 Feb 28;20(1):65-72. Epub 2018 Nov 28.

Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Disturbances of glucose metabolism are common in β-thalassemia major (β-TM).

Aim: This study was conducted to assess the pattern of glucose homeostasis in pediatric β-TM patients comparing oral glucose tolerance test (OGTT) and continuous glucose monitoring system (CGMS).

Methods: Two-hundred β-TM patients were studied and those with random blood glucose (RBG) ≥7. Read More

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http://doi.wiley.com/10.1111/pedi.12793
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http://dx.doi.org/10.1111/pedi.12793DOI Listing
February 2019
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Graduated exposure to treat fear of hypoglycemia in a young adult with type 1 diabetes: A case study.

Pediatr Diabetes 2019 Feb 5;20(1):113-118. Epub 2018 Dec 5.

Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, Colorado.

Hypoglycemia is a common and dangerous complication of type 1 diabetes (T1D). Although some worry about hypoglycemia is adaptive, some individuals develop severe and impairing anxiety symptoms about hypoglycemic episodes. This presentation, known as severe fear of hypoglycemia (FOH), is similar to a specific phobia, and becomes problematic when it interferes with one's quality of life or T1D management. Read More

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http://doi.wiley.com/10.1111/pedi.12791
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http://dx.doi.org/10.1111/pedi.12791DOI Listing
February 2019
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A randomized clinical trial to evaluate the single-dose pharmacokinetics, pharmacodynamics, and safety of sitagliptin in pediatric patients with type 2 diabetes.

Pediatr Diabetes 2019 Feb 13;20(1):48-56. Epub 2018 Nov 13.

Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey.

Objective: To evaluate the single-dose pharmacokinetics (PK), pharmacodynamics (PD), and safety of sitagliptin in pediatric patients with type 2 diabetes mellitus (T2DM).

Study Design: This was a randomized, placebo-controlled, double-blind evaluation of sitagliptin in 35 patients 10 to 17 years old with T2DM at 7 clinical research sites. The safety, tolerability, PK, and PD (dipeptidyl peptidase-4 [DPP-4] inhibition and aspects of glucose metabolism) of single doses of 50, 100, and 200 mg were assessed. Read More

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http://doi.wiley.com/10.1111/pedi.12790
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http://dx.doi.org/10.1111/pedi.12790DOI Listing
February 2019
14 Reads

Executive function and somatic problems in adolescents with above target glycemic control.

Pediatr Diabetes 2019 Feb 13;20(1):119-126. Epub 2018 Nov 13.

Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.

Adolescents with type 1 diabetes may be at elevated risk for somatic problems. This study used cross-sectional, baseline data from an intervention to examine if problems with executive function (EF) were associated with greater somatic problems independent of poor adherence and disease severity in adolescents with type 1 diabetes and above target glycemic control. In addition, it examined whether certain types of EF skills, that is, metacognitive and behavior regulation, accounted for variance in somatic problems. Read More

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http://dx.doi.org/10.1111/pedi.12789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331243PMC
February 2019

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Pediatr Diabetes 2019 Feb 19;20(1):73-77. Epub 2018 Nov 19.

Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.

Aims/hypothesis: Evidence of the role of cytomegalovirus (CMV) infection in the pathogenesis of type 1 diabetes (T1D) has remained inconclusive. Our aim was to elucidate the possible role of CMV infection in the initiation of islet autoimmunity and in the progression to clinical T1D among children with human leukocyte antigen (HLA)-conferred T1D risk.

Methods: A total of 1402 children from the prospective Type 1 Diabetes Prediction and Prevention (DIPP) study were analyzed for CMV-specific IgG antibodies during early childhood. Read More

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http://doi.wiley.com/10.1111/pedi.12788
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http://dx.doi.org/10.1111/pedi.12788DOI Listing
February 2019
12 Reads

Two's company, is three a crowd? Ethical cognition in decision making and the role of industry third parties in pediatric diabetes care.

Pediatr Diabetes 2019 Feb 5;20(1):15-22. Epub 2018 Nov 5.

Children's Bioethics Centre, Royal Children's Hospital, Melbourne, Australia.

Families of children with diabetes increasingly obtain health information from a variety of sources. Doctor-patient relationships have accordingly become more fluid and dynamic with input from other parties. These outside parties include representatives from the diabetes health care industry-industry third parties (ITPs). Read More

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http://dx.doi.org/10.1111/pedi.12786DOI Listing
February 2019
4 Reads

Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?

Pediatr Diabetes 2019 Feb 5;20(1):5-9. Epub 2018 Nov 5.

Department of Medicine, Morsani College of Medicine, University of South Florida, Florida.

Obesity is believed to be a promoter of type 2 diabetes mellitus (T2DM). Reports indicate that severe obesity in childhood and adolescence increases the risk of T2DM in youth and young adults. T2DM, which is commonly asymptomatic, frequently is not recognized until random blood glucose is measured. Read More

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http://doi.wiley.com/10.1111/pedi.12787
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http://dx.doi.org/10.1111/pedi.12787DOI Listing
February 2019
6 Reads
2.570 Impact Factor