5,624 results match your criteria Pediatric Dermatology[Journal]


Impact of skin biopsy on the management of acute graft-versus-host disease in a pediatric population.

Pediatr Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Dermatology Program, Boston Children's Hospital, Boston, Massachusetts.

Background/objectives: Acute graft-versus-host disease (GVHD) of the skin is a common complication of hematopoietic stem cell transplantation (HSCT) but often represents a diagnostic challenge. The adult literature suggests that histopathology rarely dictates management decisions, but the clinical utility of skin biopsies in pediatric patients with suspected acute GVHD is unknown. The objective of this study was to determine the frequency with which skin biopsy leads to a definitive diagnosis of acute GVHD and changes the management of acute GVHD in the pediatric population. Read More

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http://dx.doi.org/10.1111/pde.13840DOI Listing
April 2019
1 Read

Linear morphea overlying site of previous lichen aureus in a pediatric patient.

Pediatr Dermatol 2019 Apr 17. Epub 2019 Apr 17.

University of Vermont Larner College of Medicine, Burlington, Vermont.

Lichen aureus is a pigmented purpuric dermatosis that tends to occur on the lower extremities, and linear morphea is an inflammatory disease of the dermis and subcutaneous fat that leads to a scarlike induration. We present a pediatric case of linear morphea developing in the same anatomic distribution as prior lichen aureus. Due to the possible progression of lichen aureus to morphea described herein and the difficulty in diagnosing early morphea, close follow-up may be considered for pediatric patients who present with this pigmented purpuric dermatosis. Read More

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http://dx.doi.org/10.1111/pde.13834DOI Listing

Characteristics of melanoma in white and nonwhite children, adolescents, and young adults: Analysis of a pediatric melanoma institutional registry, 1995-2018.

Pediatr Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Stanford University Medical Center, Pigmented Lesion and Melanoma Program, Stanford University Medical Center and Cancer Institute, Lucile Packard Children's Hospital, Stanford, California.

Objectives: To characterize clinical differences among nonwhite/multiethnic vs white children, adolescents, and young adults with melanoma or atypical melanocytic neoplasms, including atypical Spitz tumors.

Patients And Methods: A cohort of 55 patients (< 25 years of age) prospectively followed from 1995 to 2018 in the Stanford Pigmented Lesion and Melanoma Program was analyzed for differences in clinical presentation, including skin phototype, race/ethnicity, age, sex, tumor/melanoma characteristics, and outcome.

Results: Seventeen patients (9 males and 8 females) were classified as nonwhite (predominantly skin phototype IV) and of Hispanic, Asian, or Black/African American ethnicity, and 38 patients (21 males and 17 females) were classified as white (predominantly phototypes I/II). Read More

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http://dx.doi.org/10.1111/pde.13836DOI Listing
April 2019
1 Read

Sparing of the nipple-areola complex by capillary malformations: Vascular variant of the Bork-Baykal phenomenon.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, University Children's Hospital Niño Jesús, Madrid, Spain.

The"Bork-Baykal phenomenon" refers to the sparing of the nipple-areola complex in large congenital melanocytic nevi involving the breast. So far, this finding has not been reported in vascular anomalies. We present four patients with an extensive capillary malformation (CM) involving the breast that was found to exhibit a similar sparing of the nipple and areola. Read More

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http://dx.doi.org/10.1111/pde.13844DOI Listing

Non-pruritic bullous scabies in an immunosuppressed pediatric patient.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California.

Bullous scabies is an uncommon subtype of scabies that frequently mimics other blistering skin diseases. Nocturnal pruritus is a hallmark symptom of bullous scabies. We report an unusual case of bullous scabies presenting in the absence of pruritus in an immunosuppressed pediatric patient. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.13797
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http://dx.doi.org/10.1111/pde.13797DOI Listing
April 2019
4 Reads

Sodium hypochlorite body wash in the management of Staphylococcus aureus-colonized moderate-to-severe atopic dermatitis in infants, children, and adolescents.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Objectives: A cleansing body wash containing diluted sodium hypochlorite (0.006% NaOCl) was evaluated for management of moderate-to-severe Staphylococcus aureus-colonized, atopic dermatitis in children.

Methods: A 6-week, prospective, open-label study was conducted with 50 evaluable participants (ages 6 months to 17 years) who had moderate-to-severe atopic dermatitis with S aureus skin colonization documented by culture. Read More

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http://dx.doi.org/10.1111/pde.13842DOI Listing
April 2019
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Atenolol as an alternative to propranolol for the management of sleep disturbances in the treatment of infantile hemangiomas.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Section of Dermatology, Division of General Pediatrics, Department of Pediatrics and Dermatology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Infantile hemangiomas are the most common tumors of infancy and are often managed with oral beta-blockers to address or prevent associated complications. However, treatment with propranolol can occasionally be associated with sleep disturbances, which in some cases are severe enough to warrant discontinuation or replacement with another agent. We herein report four cases in which treatment with propranolol resulted in significant sleep disturbances prompting substitution with atenolol, which in some cases resolved these issues. Read More

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http://dx.doi.org/10.1111/pde.13839DOI Listing
April 2019
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Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Division of Pediatric Dermatology, University of Minnesota, Minneapolis, Minnesota.

We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Read More

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http://dx.doi.org/10.1111/pde.13833DOI Listing

Striking contiguous depigmentation across the lower limbs in piebaldism and its implications for understanding melanocytic migration and development.

Pediatr Dermatol 2019 Apr 14. Epub 2019 Apr 14.

University of California, San Francisco, California.

Piebaldism is a rare autosomal dominant disorder of pigmentation that is characterized by variable patches of depigmentation on the face, chest, abdomen, and extremities. We describe two cases of piebaldism, in whom the remarkable asymmetric distribution of the depigmented patches in a connected, contiguous pattern across the legs provides embryologic insights. This finding is not explained by the traditional theory that melanocytic migration only originates in the neural crest and progresses unilaterally down each leg. Read More

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http://dx.doi.org/10.1111/pde.13831DOI Listing

Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: A randomized split-body control study.

Pediatr Dermatol 2019 Apr 14. Epub 2019 Apr 14.

Dell Children's Medical Center, Austin, Texas.

Background: Wet wraps can be an effective means of improving atopic dermatitis (AD). Little research has been done regarding the comparative efficacy of topical steroid vehicles and patient preference.

Objective: This study aimed to compare the efficacy of 0. Read More

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http://dx.doi.org/10.1111/pde.13830DOI Listing

Economic burden of cutaneous infections in children and adults with atopic dermatitis.

Pediatr Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, California.

Background/objectives: Atopic dermatitis (AD) is a chronic, inflammatory disease affecting both children and adults. AD is associated with multiple comorbidities and complications. In particular, AD patients are susceptible to developing cutaneous infections. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.13828
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http://dx.doi.org/10.1111/pde.13828DOI Listing
April 2019
2 Reads
1.520 Impact Factor

Pediatric dermatology and climate change: An argument for the pediatric subspecialist as public health advocate.

Pediatr Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Division of Dermatology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington.

The October 2018 report from the United Nations Intergovernmental Panel on Climate Change predicts significant threats to human health secondary to anthropogenic global warming; children have been and will continue to be disproportionately affected by these weather-related changes. Multiple physician groups have acknowledged climate change as a public health issue, calling upon providers to educate their communities about this looming health crisis while also reducing their individual carbon footprints. A significant body of literature has also documented the adverse dermatologic consequences of a warmer planet, highlighting the importance of pediatric dermatologists in addressing climate change. Read More

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http://dx.doi.org/10.1111/pde.13819DOI Listing
April 2019
1 Read

Topical timolol as adjunct therapy to shorten oral propranolol therapy for infantile hemangiomas.

Pediatr Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background/objectives: First-line therapy for infantile hemangiomas (IH) is oral propranolol, a systemic beta-blocker with the risk of rare but serious adverse effects. Topical timolol presents an attractive off-label alternative with good tolerability, but sequential therapy with propranolol followed by timolol is not well studied. Here, we report effects of topical timolol preceding or following oral propranolol as adjunct therapy for IH. Read More

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http://dx.doi.org/10.1111/pde.13816DOI Listing
April 2019
1 Read

Disseminated De Novo Myeloid Sarcoma in a 17-year-old Boy.

Pediatr Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Section of Dermatology, Division of Paediatric Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Myeloid sarcoma (MS) is a rare extramedullary tumor of malignant myeloid cells often associated with acute myeloid leukemia. We report a case of a 17-year-old boy presenting with diffuse red-brown skin nodules ultimately diagnosed with the scarcely described disseminated, de novo MS. It is important for dermatologists to keep MS on their differential when assessing patients with disseminated red-brown nodules. Read More

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http://dx.doi.org/10.1111/pde.13824DOI Listing
April 2019
3 Reads

Dental root abnormalities in four children with PHACE syndrome.

Pediatr Dermatol 2019 Apr 1. Epub 2019 Apr 1.

Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, Wisconsin.

PHACE(S) syndrome is a condition characterized by posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities, sternal cleft, and supraumbilical raphe. We present four children with PHACE(S) syndrome who have absence of or severe malformation of the roots of their permanent first molars (PFMs). Root abnormalities in the children's molars were bilateral and not restricted to the segments affected by cutaneous hemangioma. Read More

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http://dx.doi.org/10.1111/pde.13818DOI Listing
April 2019
3 Reads

Idiopathic toxic epidermal necrolysis in an adolescent.

Pediatr Dermatol 2019 Mar 31. Epub 2019 Mar 31.

Department of Dermatology, Children's National Medical Center, Washington, District of Columbia.

A 10-year-old girl, suspected 2 days prior to have streptococcal pharyngitis, presented with diffuse erythema, tense bullae, Nikolsky-positive desquamation, as well as ulcerations of her oral and genital mucosa. She denied recent travel, sick contacts, or preceding and concurrent use of medications, including over-the-counter and herbal supplements. A comprehensive viral polymerase chain reaction (PCR) panel, Mycoplasma pneumoniae PCR and IgM, streptococcal molecular antigen test, urine culture, blood culture, and rheumatologic serologies were negative. Read More

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http://dx.doi.org/10.1111/pde.13820DOI Listing

Drug reaction with eosinophilia and systemic symptoms in a cohort of Asian children.

Pediatr Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Background/objectives: Drug reaction with eosinophilia and systemic symptoms (DRESS) is rare but potentially fatal in children. Fever and rash, which are salient features of DRESS, may mimic other commonly encountered pediatric conditions. We profiled the DRESS cases in a tertiary children's hospital in Singapore. Read More

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http://dx.doi.org/10.1111/pde.13812DOI Listing
March 2019
1 Read

Treatment of benign cephalic histiocytosis with topical 1% rapamycin ointment.

Pediatr Dermatol 2019 Mar 24. Epub 2019 Mar 24.

Division of Dermatology, MedStar Georgetown University Hospital-Washington Hospital Center, Washington, District of Columbia.

We report a pediatric case of extensive, progressive benign cephalic histiocytosis (BCH) involving the face, trunk, and extremities with response of facial lesions to treatment with topical 1% rapamycin. A split-face model was used to demonstrate improvement on the treated side versus the untreated side. After physician and parental perception of effectiveness, based in part on photodocumentation, subsequently both cheeks were treated with continued improvement. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.13800
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http://dx.doi.org/10.1111/pde.13800DOI Listing
March 2019
3 Reads

Terra firma-forme dermatosis: Differential diagnosis and response to salicylic acid therapy.

Pediatr Dermatol 2019 Mar 24. Epub 2019 Mar 24.

First Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece.

Terra firma-forme dermatosis (TFFD), first described by Duncan in 1987, is a relatively common but probably underdiagnosed condition, characterized by a reticular hyperpigmented dirtlike eruption resistant to washing with common soap but typically removed with rubbing with 70% isopropyl alcohol. We present a case of TFFD in an 8-year-old boy with rapid response to 5% salicylic acid in petrolatum ointment. Read More

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http://dx.doi.org/10.1111/pde.13807DOI Listing

Congenital hemangioma exhibiting postnatal growth.

Pediatr Dermatol 2019 Mar 21. Epub 2019 Mar 21.

Division of Pediatric Dermatology, University Children's Hospital Zurich, Zurich, Switzerland.

Congenital hemangiomas are vascular tumors that are fully formed at birth, typically without postnatal growth. Noninvoluting congenital hemangiomas (NICH) have a distinctive clinical, radiologic, and histopathological profile and lack of expansion or involution over time. Herein, we describe two cases of NICH with atypical postnatal growth. Read More

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http://dx.doi.org/10.1111/pde.13813DOI Listing
March 2019
1 Read
1.520 Impact Factor

Parent and child perspectives on perceived barriers to child sun protection and their association with sun protection strategies among children of melanoma survivors.

Pediatr Dermatol 2019 Mar 20. Epub 2019 Mar 20.

Department of Dermatology & Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

Background/objectives: Children with an elevated familial risk for melanoma inconsistently implement sun protection behaviors that could mitigate their melanoma risk. Little is known about perceived barriers to child sun protection among this at-risk group and their parents, and the extent to which perceived barriers are associated with child sun protection. The goal of this study was to examine, among children with a family history of melanoma, the frequency with which children and their parents reported barriers to child sun protection and the extent to which barriers were associated with reported use of sun protection among children. Read More

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http://dx.doi.org/10.1111/pde.13796DOI Listing

Woolly hair, palmoplantar keratoderma, skin fragility, and perioral fissures in a toddler.

Pediatr Dermatol 2019 Mar;36(2):255-257

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1111/pde.13711DOI Listing

Patient Perspectives: What is hidradenitis suppurativa (HS)?

Authors:

Pediatr Dermatol 2019 03;36(2):249-250

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http://dx.doi.org/10.1111/pde.13832DOI Listing

Papule on the pre-tragus of an adolescent.

Pediatr Dermatol 2019 Mar;36(2):251-252

Advanced Dermatology Associates, Allentown, Pennsylvania.

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http://dx.doi.org/10.1111/pde.13735DOI Listing

Two siblings with scarlike facial lesions.

Pediatr Dermatol 2019 Mar;36(2):253-254

Department of Pediatrics, O.L.Vrouw Hospital, Aalst, Belgium.

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http://dx.doi.org/10.1111/pde.13718DOI Listing

Comment on "What's the story? An analysis of children's books about atopic dermatitis".

Authors:
Rosie Wellesley

Pediatr Dermatol 2019 03;36(2):268

Mile End East and Bromley by Bow Health CIC Ltd, London, UK.

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http://dx.doi.org/10.1111/pde.13743DOI Listing

Inner thigh friction as a cause of acne mechanica.

Pediatr Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Childrens National Medical Center, Washington, District of Columbia.

Acne mechanica is defined as being any acneiform eruption in areas of friction, pressure, stretching, rubbing, pinching, or occlusion of the skin in any individual, regardless of preexisting acne. Various causes have been reported, including prolonged back rest against a chair or bed, occlusive clothing, pressure from a prosthetic limb, and others. This is the first reported case of bilateral open comedones caused by inner thigh friction. Read More

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http://dx.doi.org/10.1111/pde.13817DOI Listing

Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans.

Pediatr Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Thailand.

Background: There have been few published randomized controlled trials for the treatment of childhood acanthosis nigricans (AN) to date.

Objective: To assess the efficacy of topical 0.1% adapalene gel compared to 0. Read More

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http://dx.doi.org/10.1111/pde.13799DOI Listing

A novel treatment for idiopathic knuckle pads with cantharidin-podophylotoxin-salicylic acid.

Pediatr Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Pontificia Universidad Católica de Chile, Santiago, Chile.

Knuckle pads are benign subcutaneous nodules that appear most frequently on the small joints of the hands. In children, they are often idiopathic, and no universally effective treatment has been reported. We present the case of an adolescent successfully treated with a combination of topical cantharidin -podophylotoxin -salicylic acid. Read More

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http://dx.doi.org/10.1111/pde.13803DOI Listing

Topical corticosteroid phobia among caretakers of children with atopic dermatitis: A cross-sectional study using TOPICOP in Japan.

Pediatr Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Background/objectives: The TOPICOP scale is an easy-to-use scale for assessing topical corticosteroid (TCS) phobia in atopic dermatitis (AD) patients and their caretakers. TCS phobia is a common problem among AD patients and their caretakers. The aim of this study was to examine the relationship between TCS phobia in caretakers of children with AD and the characteristics of patients using the TOPICOP scale. Read More

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http://dx.doi.org/10.1111/pde.13784DOI Listing

Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.

Pediatr Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, New York.

Neurocutaneous melanosis (NCM) is the condition of abnormal melanocyte deposition in the leptomeninges and brain parenchyma. Associated with congenital melanocytic nevi, NCM can result in neurologic deficits, hydrocephalus, and rarely, malignant transformation of cells. We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. Read More

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http://dx.doi.org/10.1111/pde.13804DOI Listing
March 2019
4 Reads

"Slime" contact dermatitis: Case report and review of relevant allergens.

Pediatr Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.

Homemade "slime" is currently a popular childhood hobby that can cause allergic and irritant contact dermatitis. We describe a case of hand dermatitis due to homemade "slime" with a positive patch test to methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) and MI. The most common potential allergens in "slime" collected from a review of "slime" recipes found on the Internet are reviewed. Read More

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http://dx.doi.org/10.1111/pde.13792DOI Listing
March 2019
1 Read

A case of woolly hair nevus, multiple linear pigmentation, and epidermal nevi with somatic HRAS p.G12S mutation.

Pediatr Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Woolly hair nevus is a rare syndrome that presents as woolly hair in restricted areas of the scalp and may be associated with pigmented macules or epidermal nevus on the body. Here, we report a case of woolly hair nevus, linear pigmentation, and multiple epidermal nevi with a somatic HRAS c.34G>A(p. Read More

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http://dx.doi.org/10.1111/pde.13783DOI Listing

Buzzing away the pain: Using an electric toothbrush for vibration anesthesia during painful procedures.

Pediatr Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.

Many dermatologic procedures are painful and traumatic, for both pediatric patients and providers alike. Vibration anesthesia has recently been discussed as an effective method for reducing pain associated with injections, but some vibration machines can be cost prohibitive for providers. We describe how to employ an electric toothbrush as an inexpensive and effective option to provide vibration anesthesia during painful pediatric procedures. Read More

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http://dx.doi.org/10.1111/pde.13802DOI Listing

Plexiform fibrohistiocytic tumor on the chest of a 5-year-old child and review of the literature.

Pediatr Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Plexiform fibrohistiocytic tumor (PFT) is a rare neoplasm of mesenchymal origin that can be identified by its propensity for children and adolescents combined with a characteristic histologic arrangement of histiocytes and osteoclast-like giant cells whorled within tumor islands. A 5-year-old female presented with a raised, intermittently tender, and slowly enlarging tumor on her chest, which was histologically confirmed to be a PFT. We present this case along with a comprehensive review of PFT cases reported in the literature to describe the demographic, histologic, and rarely metastatic behavior of this entity. Read More

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http://dx.doi.org/10.1111/pde.13805DOI Listing

Lymphoplasmacytic plaque in children: Case report and literature review.

Pediatr Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, Grand Hôpital de Charleroi, Charleroi, Belgium.

We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm. Read More

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http://dx.doi.org/10.1111/pde.13811DOI Listing

Herpetic whitlow of the toe presenting with severe viral cellulitis.

Pediatr Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California.

Herpetic whitlow of the toe is a common infection in an uncommon location, leading it to be frequently misdiagnosed; however, as the virus responds well to conservative management or antivirals alone, proper identification is necessary to prevent unnecessary interventions. We present a case of herpetic whitlow of the toe with an unusually ominous appearance in a previously healthy and otherwise well-appearing child. This case illustrates the spectrum of herpetic whitlow's clinical presentations and enourages consideration of the disease even for atypical location and severity. Read More

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http://doi.wiley.com/10.1111/pde.13795
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http://dx.doi.org/10.1111/pde.13795DOI Listing
March 2019
5 Reads

"Regoaling": A useful tool for improved patient/parent communication in pediatric dermatology.

Pediatr Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut.

"Regoaling" is a term for the process by which patients and their families develop new care and life-related goals in response to changes in an individual's medical condition. While this term draws its roots from the pediatric critical and palliative care literature where it has been developed to provide a path to assist families in transitioning their child's care goals, regoaling has the potential to be a very important communication tool for pediatric dermatologists who are the primary managers of chronic, unrelenting skin diseases in children. Herein, we introduce the concept of regoaling to pediatric dermatology and provide practical advice on how and when to assist patients and their families with regoaling. Read More

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http://doi.wiley.com/10.1111/pde.13806
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http://dx.doi.org/10.1111/pde.13806DOI Listing
March 2019
6 Reads

Perioperative anaphylaxis in a patient with a solitary mastocytoma.

Pediatr Dermatol 2019 Mar 10. Epub 2019 Mar 10.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Children with more extensive cutaneous mastocytosis have a higher risk for symptoms secondary to release of mast cell mediators. However, the remote possibility of anaphylaxis in patients with a solitary lesion suggests the need for cautious use of general anesthesia in these children. We describe an unusual case of a patient with a solitary mastocytoma who experienced an anaphylactic reaction during a surgical procedure and make recommendations to reduce the risk of intraoperative anaphylaxis in mast cell disease. Read More

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http://doi.wiley.com/10.1111/pde.13777
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http://dx.doi.org/10.1111/pde.13777DOI Listing
March 2019
6 Reads

Dermatofibrosarcoma protuberans in a pediatric patient with ataxia telangiectasia syndrome.

Pediatr Dermatol 2019 Mar 10. Epub 2019 Mar 10.

Cooper Medical School of Rowan University, Camden, NJ.

Ataxia telangiectasia (AT) is a rare autosomal recessive neurodegenerative disorder caused by a mutation in the ATM gene. An impaired immune response due to the gene mutation leads to an increased risk of infection and malignancy. We present a rare case of dermatofibrosarcoma protuberans arising in a patient with AT. Read More

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http://doi.wiley.com/10.1111/pde.13779
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http://dx.doi.org/10.1111/pde.13779DOI Listing
March 2019
6 Reads

Full-term newborn infant with blistering skin lesions-Caution regarding use of pain medications.

Pediatr Dermatol 2019 Mar 10. Epub 2019 Mar 10.

Department of Pediatrics, Division of Neonatology, University of Connecticut, Farmington, Connecticut.

Multiple opioids are known to trigger mast cell degranulation. We report the case of a neonate with blistering skin lesions at birth who died of multi-organ failure after administration of morphine. Given the excessive histamine release and potential complications associated with morphine administration, alternative opioids and adjuvants should be considered in infants presenting with evidence of bullous or infiltrative skin lesions until mastocytosis is ruled out. Read More

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http://dx.doi.org/10.1111/pde.13794DOI Listing
March 2019
1 Read

Ectopic immature renal tissue presenting as a pedunculated sacral mass in a neonate.

Pediatr Dermatol 2019 Mar 6. Epub 2019 Mar 6.

University of Toronto, Toronto, Ontario.

Ectopic immature renal tissue (EIRT) has been reported in a variety of tissues of mesodermal origin, including the dermis of the skin. We report a case of a newborn with a congenital lumbosacral mass with pathologic findings consistent with EIRT. This report highlights the clinical and pathologic considerations of EIRT, including associations with spinal dysraphism, teratoma, and Wilm's tumor. Read More

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http://dx.doi.org/10.1111/pde.13809DOI Listing

Evolution of congenital melanocytic nevi toward benignity: A case series.

Pediatr Dermatol 2019 Mar 6;36(2):227-231. Epub 2019 Mar 6.

Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.

We report on four children born with medium to large congenital melanocytic nevi (CMN) with color heterogeneity and irregular surface rugosity. As these patients aged, their nevi evolved to become more homogeneous and lighter in color, and developed a smoother, more even texture. We propose that given this evolution toward benignity, conservative monitoring and management may be appropriate even in the context of atypical-appearing features at birth. Read More

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http://dx.doi.org/10.1111/pde.13745DOI Listing
March 2019
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Allergic contact dermatitis to chlorhexidine in pediatric patients.

Pediatr Dermatol 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

Chlorhexidine is one of the most widely used antiseptics in our environment. Allergic contact dermatitis to chlorhexidine is common in adults, but is quite rare in the pediatric population. Its diagnosis is important because it can mimic other dermatoses common during childhood, and it can also lead to acute immediate hypersensitivity reactions following successive exposures. Read More

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http://dx.doi.org/10.1111/pde.13808DOI Listing
March 2019
5 Reads

Inflammatory linear verrucous epidermal nevus treated successfully with crisaborole ointment in a 5-year-old boy.

Pediatr Dermatol 2019 Mar 5. Epub 2019 Mar 5.

Duke University School of Medicine, Durham, North Carolina.

Inflammatory linear verrucous epidermal nevus (ILVEN) is a chronic, a linear, or whorled array of inflammatory, following the lines of Blaschko. Treatment of ILVEN is challenging with numerous therapies of varying degrees of success reported. We present a case of ILVEN in a 5-year-old-boy, treated successfully with crisaborole 2% ointment. Read More

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http://dx.doi.org/10.1111/pde.13793DOI Listing

Pediatric toxic epidermal necrolysis treated successfully with infliximab.

Pediatr Dermatol 2019 Mar 4. Epub 2019 Mar 4.

Departments of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Read More

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http://dx.doi.org/10.1111/pde.13778DOI Listing
March 2019
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Hookworm-related cutaneous larva migrans of the penis successfully treated with topical ivermectin.

Pediatr Dermatol 2019 Mar 3. Epub 2019 Mar 3.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Hookworm-related cutaneous larva migrans is an infestation of the skin caused by nematodes. Involvement of genitals is extremely rare. We report the case of a child with this infestation on the penis who cleared rapidly with topical ivermectin. Read More

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http://dx.doi.org/10.1111/pde.13789DOI Listing
March 2019
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Management of a neonate with diffuse cutaneous mastocytosis: Case report and literature review.

Pediatr Dermatol 2019 Mar 3. Epub 2019 Mar 3.

Department of Internal Medicine (Dermatology), Dell Medical School at The University of Texas at Austin, Austin, Texas.

Mastocytosis is an accumulation of clonal mast cells within tissues, commonly caused by mutations in the KIT proto-oncogene. This report describes the management of a neonate with diffuse cutaneous mastocytosis (DCM) caused by a rare activating KIT mutation, specifically internal tandem duplication of the Ala502Tyr503 pair on exon 9, and reviews current data regarding work-up of DCM in pediatric patients. Read More

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http://dx.doi.org/10.1111/pde.13801DOI Listing

Topical sirolimus as an effective treatment for a deep neurofibroma in a patient with neurofibromatosis type I.

Pediatr Dermatol 2019 Mar 3. Epub 2019 Mar 3.

University of Alberta, Edmonton, Alberta, Canada.

A 14-year-old boy with neurofibromatosis type I (NF1) presented with a painful neurofibroma on his right palm. The lesion was treated with topical sirolimus, resulting in decreased size and pain and improvement in motor function of his hand. This case demonstrates the efficacy of topical sirolimus in the management of neurofibromas in NF1. Read More

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http://dx.doi.org/10.1111/pde.13782DOI Listing
March 2019
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Dermoscopy of subungual red comets associated with tuberous sclerosis complex.

Pediatr Dermatol 2019 Mar 3. Epub 2019 Mar 3.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

We report here our experience on the use of dermoscopy for the detection of subungual red comets, which are sometimes present in the nails of patients affected by tuberous sclerosis complex. Dermoscopy allowed us to visualize, with better resolution than the naked eye, very tortuous capillaries surrounded by a whitish halo and close parallel binary tortuous capillaries. In some cases, subungual red comets are associated with the presence of periungual or subungual fibromas, but their exact pathogenesis remains unknown. Read More

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http://dx.doi.org/10.1111/pde.13798DOI Listing
March 2019
3 Reads