5,554 results match your criteria Pediatric Dermatology[Journal]


Acanthosis nigricans, hypochondroplasia, and FGFR3 mutations: Findings with five new patients, and a review of the literature.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, CHU Nantes, Nantes, France.

Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. Read More

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http://dx.doi.org/10.1111/pde.13748DOI Listing
February 2019

Childhood pemphigus foliaceus presenting as a polycyclic eruption: Case report and review of the literature.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Pemphigus foliaceus (PF) is an autoimmune bullous disorder that has occasionally been reported to present as a polycyclic or arcuate eruption in children. We present a case of childhood PF presenting as an annular and polycyclic eruption, which initially led to a diagnostic conundrum and a delay in diagnosis but which ultimately responded well to therapy with systemic steroids and rituximab infusions. We briefly review the literature on polycyclic presentations of PF in childhood as well as the use of rituximab for pediatric pemphigus. Read More

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http://dx.doi.org/10.1111/pde.13750DOI Listing
February 2019

Localized vulvar bullous pemphigoid of childhood: A rare cause of persistent vulvar erosions in children.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Dermatology, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.

Localized vulvar bullous pemphigoid of childhood is an excessively rare variant of bullous pemphigoid and affects almost exclusively young girls of 7-12 years of age. In contrast to adult-onset bullous pemphigoid, a prompt response to potent topical corticosteroids is observed in the majority of cases, with a favorable prognosis and rare relapses. We report the case of a 7-year-old girl who presented with this condition. Read More

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http://dx.doi.org/10.1111/pde.13771DOI Listing
February 2019

A barrier to care: Distance traveled affects adherence to treatment and follow-up plans for patients with infantile hemangioma.

Pediatr Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Texas Children's Hospital, The Woodlands, Texas.

A chart review was performed of all patients diagnosed with infantile hemangioma in the pediatric dermatology clinic to determine whether distance traveled by the patient affected adherence to follow-up and treatment plans. An increase in distance was associated with an increase in likelihood of nonadherence to treatment or follow-up plans. Compared to patients who lived within 10 miles of a pediatric dermatologist, families who lived farther away were less likely to adhere to treatment plans. Read More

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http://dx.doi.org/10.1111/pde.13788DOI Listing
February 2019

Trichoscopy features of trichotillomania.

Pediatr Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology, Hospital Clinico Universitario, Valencia, Spain.

Trichotillomania is a form of traction alopecia resulting from repetitive and compulsive hair pulling and plucking. Trichotillomania and patchy alopecia areata may have similar clinical and dermoscopic features in some cases. On trichoscopic examination, the presence of black dots, coiled or hook hair, shafts of varying lengths with fraying or split ends (trichoptilosis), and an absence of exclamation mark hairs and yellow dots are suggestive of trichotillomania. Read More

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http://dx.doi.org/10.1111/pde.13756DOI Listing
February 2019

Pediatric lichen nitidus: A single-center experience.

Pediatr Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Dr. Behcet Uz Children's Research and Training Hospital, Izmir, Turkey.

Objective: Lichen nitidus (LN) is an uncommon inflammatory skin eruption. The present study aims to describe a case series of children with LN seen at a tertiary-care health center.

Methods: Retrospective study of 17 children with biopsy-proven LN between January 2007 and March 2017. Read More

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http://doi.wiley.com/10.1111/pde.13749
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http://dx.doi.org/10.1111/pde.13749DOI Listing
February 2019
1 Read

Neutrophilic Panniculitis in a child with MYSM1 deficiency.

Pediatr Dermatol 2019 Feb 12. Epub 2019 Feb 12.

Paediatric Haematology Unit, Mubarak Al-Kabeer Hospital, Kuwait.

Neutrophilic panniculitis (NP) with myelodysplasia has been described in adults but not in children. We report a case of NP associated with myelodysplasia in a child with MYSM1 deficiency, a newly described syndrome with primary immunodeficiency (PI), bone marrow failure, and developmental aberrations. Read More

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http://dx.doi.org/10.1111/pde.13757DOI Listing
February 2019

Botulinum toxin A for pain reduction in pediatric patients with Parry-Romberg syndrome.

Pediatr Dermatol 2019 Feb 10. Epub 2019 Feb 10.

Pediatric Dermatology, Phoenix Children's Hospital, Phoenix, Arizona.

Parry-Romberg syndrome (PRS) is characterized by hemiatrophy of facial structures, including skin, subcutaneous fat, muscle, bone, and cartilage. Complications associated with PRS include headaches, seizures, and chronic facial pain. Protocol for the treatment of chronic facial pain is not clear; reports on the use of botulinum toxin A injections for pain reduction in adults but not in the pediatric/adolescent population are available. Read More

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http://dx.doi.org/10.1111/pde.13746DOI Listing
February 2019
1 Read

Use of psychologic strategies to reduce pain and anxiety related to dermatology procedures.

Pediatr Dermatol 2019 Feb 10. Epub 2019 Feb 10.

Dell Children's Medical Center, Austin, Texas.

The fear of painful procedures is at an increased incidence within the pediatric population. This can be an extremely challenging obstacle in dermatology where injections, blood draws, and cryotherapy are often required during the care of patients. Psychologic techniques based on cognitive behavioral therapy (CBT) can be implemented leading up to and while performing these procedures to help reduce patient anxiety. Read More

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http://dx.doi.org/10.1111/pde.13739DOI Listing
February 2019

Enlarging lesion on the back of a 17-year-old boy.

Pediatr Dermatol 2019 Jan;36(1):163-165

Division of Dermatology, University of Texas Health San Antonio, San Antonio, Texas.

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http://dx.doi.org/10.1111/pde.13696DOI Listing
January 2019

A solitary pedunculated nodule of the knee.

Pediatr Dermatol 2019 Jan;36(1):152-153

Department of Dermatology, Virginia Commonwealth University Health System, Richmond, Virginia.

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http://dx.doi.org/10.1111/pde.13685DOI Listing
January 2019

Comment on "Pediatric dermatology workforce in the United States".

Pediatr Dermatol 2019 01;36(1):177-178

Dermatology Program, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1111/pde.13737DOI Listing
January 2019

A case of penile swelling in a 6-year-old boy.

Pediatr Dermatol 2019 Jan;36(1):158-159

University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1111/pde.13700DOI Listing
January 2019

Response to "Dermatoscopic features of lichen nitidus".

Pediatr Dermatol 2019 01;36(1):179

Departments of Dermatology and STD and Pathology, University College of Medical Sciences and GTB Hospital, Delhi, India.

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http://dx.doi.org/10.1111/pde.13693DOI Listing
January 2019
1.520 Impact Factor

Symmetric, tender papules, and plaques involving the upper extremities in a 15-year-old man.

Pediatr Dermatol 2019 Jan;36(1):156-157

Division of Dermatology, Children's National Health System, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1111/pde.13705DOI Listing
January 2019

Innumerable lentigines in a mother and daughter.

Pediatr Dermatol 2019 Jan;36(1):160-162

Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1111/pde.13701DOI Listing
January 2019

Fleshy pink nodule on the scalp.

Pediatr Dermatol 2019 Jan;36(1):154-155

University of Texas Health Science Center at San Antonio, San Antonio, Texas.

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http://dx.doi.org/10.1111/pde.13687DOI Listing
January 2019

Nodular lesion in right thigh with hypertrichosis in a 2-year-old girl.

Pediatr Dermatol 2019 Jan;36(1):145-146

Department of Dermatology, I+12 Research Institute, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1111/pde.13665DOI Listing
January 2019

Nail dystrophy and oral leukoplakia in a 3-year-old girl.

Pediatr Dermatol 2019 Jan;36(1):149-151

Department of Dermatology, Hospital Sant Joan de Déu, Barcelona, Spain.

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http://dx.doi.org/10.1111/pde.13690DOI Listing
January 2019

Six-year-old male with a chief complaint of telangiectasias.

Pediatr Dermatol 2019 Jan;36(1):147-148

Department of Dermatology, University of Virginia School of Medicine, Charlottesville, Virginia.

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http://dx.doi.org/10.1111/pde.13666DOI Listing
January 2019
1 Read

Patient Perspectives: What is a pilomatricoma?

Authors:

Pediatr Dermatol 2019 01;36(1):143

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http://dx.doi.org/10.1111/pde.13787DOI Listing
January 2019

Use of dupilimab in pediatric atopic dermatitis: Access, dosing, and implications for managing severe atopic dermatitis.

Pediatr Dermatol 2019 01;36(1):172-176

Feinberg School of Medicine, Northwestern University and Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1111/pde.13707DOI Listing
January 2019
1 Read

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris in a preadolescent population.

Pediatr Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Dow Pharmaceutical Sciences Inc., Petaluma, California.

Background: Acne vulgaris (acne) is a common skin condition in children and adolescents. Efficacy of tretinoin is well documented in studies that included pediatric patients (12-18 years of age). With acne routinely presenting in younger patients, data are needed in this important group. Read More

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http://dx.doi.org/10.1111/pde.13744DOI Listing
January 2019

The microbiome in preadolescent acne: Assessment and prospective analysis of the influence of benzoyl peroxide.

Pediatr Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California.

Background/objectives: The pathogenesis of preadolescent acne has not been well studied, and it is uncertain if Cutibacterium acnes is a predominant organism in the microbiome in this age group. The aim of this study was to analyze the microbiome of preadolescent females and to assess whether benzoyl peroxide impacts the microbiome.

Methods: The study enrolled girls, aged 7-12 years, with evidence of at least six acne lesions who had not been previously treated. Read More

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http://dx.doi.org/10.1111/pde.13741DOI Listing
January 2019

Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.

Pediatr Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. Read More

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http://dx.doi.org/10.1111/pde.13738DOI Listing
January 2019
1 Read

Subepidermal calcified nodule on the periungual finger successfully treated with ablative carbon dioxide laser.

Pediatr Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Subepidermal calcified nodules are lesions that primarily affect children and are most commonly located on the head. The current standard of treatment for these is surgical excision. However, surgical excision is not always possible and may not be cosmetically favorable. Read More

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http://dx.doi.org/10.1111/pde.13742DOI Listing
January 2019

Bullous pemphigoid in adolescence.

Pediatr Dermatol 2018 Dec 19. Epub 2018 Dec 19.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.

Bullous pemphigoid (BP) is the most common autoimmune blistering disease affecting the elderly but is quite rare in childhood. The majority of pediatric cases have been reported during early childhood. Adolescence is divided into three phases: early (10-13 years), middle (14-17), and late (18-21). Read More

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http://doi.wiley.com/10.1111/pde.13717
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http://dx.doi.org/10.1111/pde.13717DOI Listing
December 2018
2 Reads

Successful treatment of hemorrhagic bullous Henoch-Schonlein purpura with intravenous immunoglobulins.

Pediatr Dermatol 2019 Jan 18;36(1):e34-e36. Epub 2018 Dec 18.

Department of Paediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in childhood. There is no consensus about the management for isolated cutaneous manifestations in HSP. We describe a case of HSP presenting with severe skin lesions that did not respond to standard therapy with corticosteroids. Read More

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http://dx.doi.org/10.1111/pde.13715DOI Listing
January 2019
1 Read

Biology of human melanocyte development, Piebaldism, and Waardenburg syndrome.

Pediatr Dermatol 2019 Jan 18;36(1):72-84. Epub 2018 Dec 18.

University of Florida College of Medicine, Gainesville, Florida.

Melanocyte development is orchestrated by a complex interconnecting regulatory network of genes and synergistic interactions. Piebaldism and Waardenburg syndrome are neurocristopathies that arise from mutations in genes involved in this complex network. Our understanding of melanocyte development, Piebaldism, and Waardenburg syndrome has improved dramatically over the past decade. Read More

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http://dx.doi.org/10.1111/pde.13713DOI Listing
January 2019

A case of focal facial dermal dysplasia type 4.

Pediatr Dermatol 2019 Jan 18;36(1):e58-e59. Epub 2018 Dec 18.

Medway NHS Foundation Trust, Gillingham, UK.

We present a rare case of focal facial dermal dysplasia type 4 (FFDD4) in an otherwise healthy boy infant, presenting as bilateral preauricular scarlike defects surrounded by a hair collar, resembling membranous aplasia cutis congenita. The presence of a hair collar supports the hypothesis that FFDD is caused by abnormal closure at facial embryonic fusion lines, but unlike midline scalp defects is not associated with neurological compromise. Other types of FFDD occur at different sites and can be associated with cranial dysgraphism. Read More

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http://dx.doi.org/10.1111/pde.13730DOI Listing
January 2019
1 Read

The impact of pediatric atopic dermatitis on families: A review.

Pediatr Dermatol 2019 Jan 16;36(1):66-71. Epub 2018 Dec 16.

Department of Dermatology, University of California San Francisco, San Francisco, California.

Background: Atopic dermatitis (AD) is an extremely common childhood disease, with considerable impact on the quality of life of affected children and their families. While pruritus is the hallmark symptom of this disease, AD has been well-documented to impact patients beyond physical symptoms, resulting in behavior problems, mood disorders, and sleep disturbance.

Objective: This literature review outlines how atopic dermatitis impacts the quality of life of families of children affected by AD. Read More

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http://dx.doi.org/10.1111/pde.13727DOI Listing
January 2019

"Slime" dermatitis, a fad-associated chronic hand dermatitis.

Pediatr Dermatol 2019 Jan 16;36(1):e39-e40. Epub 2018 Dec 16.

Division of Dermatology, Children's National Health Center, Washington, District of Columbia.

"Slime" is the colloquial name for a non-Newtonian viscoelastic putty-like substance that is currently a popular plaything among pre-teens and adolescents. Several ingredients in homemade slime recipes may cause irritant or allergic contact dermatitis. We report two children who developed slime-associated chronic hand dermatitis, more prominently on their dominant hand. Read More

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http://dx.doi.org/10.1111/pde.13729DOI Listing
January 2019
2 Reads

Evidence-based skin care in preterm infants.

Pediatr Dermatol 2019 Jan 12;36(1):16-23. Epub 2018 Dec 12.

Department of Dermatology, University of California, San Diego School of Medicine, San Diego, California.

Most guidelines on neonatal skin care emphasize issues pertaining to healthy, term infants. Few address the complex task of skin barrier maintenance in preterm, very preterm, and extremely preterm infants. Here, we provide an evidence-based review of the literature on skin care of preterm neonates. Read More

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http://dx.doi.org/10.1111/pde.13725DOI Listing
January 2019
3 Reads

Improvement of hereditary palmoplantar keratoderma with oral trametinib.

Pediatr Dermatol 2019 Jan 12;36(1):e48-e49. Epub 2018 Dec 12.

Dermatology Program, Boston Children's Hospital, Boston, Massachusetts.

We report a child with a past medical history notable for congenital deafness, palmoplantar keratoderma (PPK), and hypothalamic glioma who initiated a MEK inhibitor trametinib for cancer-directed therapy at 11 years of age and was incidentally noted to have marked improvement in his PPK. Trametinib withdrawal led to worsening in the patient's PPK. We speculate that the patient's PPK improved because of trametinib, given the temporal relationship between trametinib therapy and PPK severity, observed both after introduction and withdrawal of trametinib therapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.13731
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http://dx.doi.org/10.1111/pde.13731DOI Listing
January 2019
5 Reads

Transverse melanonychia in a child receiving chemotherapy.

Pediatr Dermatol 2019 Jan 12;36(1):e60-e61. Epub 2018 Dec 12.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Transverse melanonychia is a rare finding often secondary to chemotherapy, orally ingested medications, or other iatrogenic interventions. A 19-month-old boy with hemophagocytic lymphohistiocytosis treated with biweekly etoposide and dexamethasone developed transverse bands of pigment in all toenail and fingernail units consistent with transverse melanonychia. We review the literature for reported cases of transverse melanonychia and summarize suspected etiologies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.13721
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http://dx.doi.org/10.1111/pde.13721DOI Listing
January 2019
10 Reads
1.520 Impact Factor

Tinea faciei starting at day two of life.

Pediatr Dermatol 2019 Jan 11;36(1):e20-e22. Epub 2018 Dec 11.

Department of Dermatology, Children's of Alabama, Birmingham, Alabama.

Dermatophyte infections are exceedingly rare in neonates, possibly due to the thin stratum corneum and high sebum content of neonatal skin. Only a handful of cases of tinea faciei have been reported in neonates, with the majority of reports occuring in India. Here, we report what to our knowledge is the earliest reported presentation of tinea faciei in the United States. Read More

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http://dx.doi.org/10.1111/pde.13724DOI Listing
January 2019
2 Reads

Primary cutaneous CD4+ small- to medium-sized pleomorphic T-cell lymphoproliferative disorder in a pediatric patient successfully treated with low-dose radiation.

Pediatr Dermatol 2019 Jan 11;36(1):e23-e26. Epub 2018 Dec 11.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Primary cutaneous CD4+ small- to medium-sized pleomorphic T-cell lymphoproliferative disorder (PCSM-LPD) is a rare and low-grade form of cutaneous T-cell proliferation with the average age of diagnosis of 54 years. Because of its rarity, the etiology or exact clinicopathology of PCSM-LPD remains unclear, with < 10 pediatric cases reported. A 13-year-old boy presented to our clinic with a raised tumor with PCSM-LPD histology and was successfully treated with ultra-low-dose radiation therapy. Read More

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http://dx.doi.org/10.1111/pde.13728DOI Listing
January 2019

Classic pseudoxanthoma elasticum in a girl with sickle cell disease.

Pediatr Dermatol 2019 Jan 9;36(1):e64-e65. Epub 2018 Dec 9.

Department of Dermatology and Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

A pseudoxanthoma elasticum (PXE)-like phenotype develops in a subset of patients with inherited hemoglobinopathies. Although PXE tissue changes are thought to develop in the absence of ABCC6 mutations in patients with beta-thalassemia, ABCC6 mutations have not been well evaluated among sickle cell disease patients with PXE-like disease. To our knowledge, we describe the first patient with sickle cell disease, PXE skin findings, and two confirmed pathogenic ABCC6 mutations. Read More

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http://dx.doi.org/10.1111/pde.13712DOI Listing
January 2019
4 Reads

Investigating skin age analysis to reduce tanning intentions among adolescents: A pilot study.

Pediatr Dermatol 2019 Jan 5;36(1):e50-e52. Epub 2018 Dec 5.

Department of Dermatology, University of Utah, Salt Lake City, Utah.

As skin cancer rates continue to rise, targeted efforts to reduce excessive exposure to ultraviolet radiation are crucial. Adolescents are a high-risk population for intentional tanning; thus, we sought to determine whether the novel use of skin age analysis with ultraviolet (UV) photography would be an effective tool for reducing intentions to tan in adolescents with a calculated skin age (measured by complexion analysis software) that exceeds their actual age. Surveying 85 students in this study, skin age difference above zero was associated with reduced intentions to tan (P = 0. Read More

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http://dx.doi.org/10.1111/pde.13734DOI Listing
January 2019
2 Reads

The effectiveness of topical therapy combined with 308-nm excimer laser on vitiligo compared to excimer laser monotherapy in pediatric patients.

Pediatr Dermatol 2019 Jan 5;36(1):e53-e55. Epub 2018 Dec 5.

Department of Dermatology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

We evaluated the efficiency of using a 308-nm excimer laser with either tacrolimus, pimecrolimus, or halometasone for the treatment of childhood vitiligo. Patients who received combined treatments had significantly higher rates of repigmentation in comparison with individuals who underwent excimer laser alone therapy. Moreover, patients who received treatment with excimer laser and halometasone had significantly higher rates of repigmentation, even higher than individuals who were treated with tacrolimus combined or pimecrolimus combined. Read More

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http://dx.doi.org/10.1111/pde.13726DOI Listing
January 2019
4 Reads

Neurocognitive function in moderate-severe pediatric atopic dermatitis: A case-control study.

Pediatr Dermatol 2019 Jan 2;36(1):110-114. Epub 2018 Dec 2.

Division of Dermatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois.

Background/objectives: Epidemiological studies have shown an increased prevalence of attention deficit hyperactivity disorder (ADHD) in children with atopic dermatitis (AD), but many of the features of ADHD may occur as a result of the poor sleep and itch distraction associated with AD.

Methods: A case-control study was performed in children aged 6-17 years with moderate/severe AD compared with age-/sex-matched healthy controls. Participants were screened for ADHD using Vanderbilt assessments. Read More

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http://dx.doi.org/10.1111/pde.13710DOI Listing
January 2019
1 Read

Atypical presentation of necrobiosis lipoidica in a pediatric patient.

Pediatr Dermatol 2019 Jan 2;36(1):e31-e33. Epub 2018 Dec 2.

Dermatology Department, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.

Necrobiosis lipoidica (NL) is a rare chronic granulomatous inflammatory skin disease characterized by brownish-red papules and yellowish plaques with atrophic centers, which usually affect the legs, bilaterally. The average age of onset is 30-40 years, and there are very few reported cases of necrobiosis lipoidica in children. A nondiabetic girl aged 14 years presented to our clinic with a history of an asymptomatic, 7 × 5-cm single red plaque over her back in the interscapular area, which had started 5 years ago. Read More

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http://doi.wiley.com/10.1111/pde.13716
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http://dx.doi.org/10.1111/pde.13716DOI Listing
January 2019
15 Reads

Neonatal skin care: Developments in care to maintain neonatal barrier function and prevention of diaper dermatitis.

Pediatr Dermatol 2019 Jan 2;36(1):31-35. Epub 2018 Dec 2.

Skin Health Alliance, London, UK.

Background: Understanding the importance of the barrier function of the skin of preterm and term neonates is crucial in effective neonatal skin and diaper care. This literature search aimed to review the development of different practices in neonatal care to maintain skin barrier function, in turn preventing diaper dermatitis.

Methods: We performed two quantitative literature searches of English language studies: an initial literature search of studies published in the last 5 years was conducted using Cinahl, Medline, Embase, British Nursing Index, and DelphiS, followed by a second search of publications from 1990 to 2017 using the National Institute of Clinical Excellence Health Databases Advanced Search using key words, synonyms, and Boolean phrasing. Read More

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http://dx.doi.org/10.1111/pde.13714DOI Listing
January 2019
1 Read

Epidermolysis bullosa simplex-generalized severe type due to keratin 5 p.Glu477Lys mutation: Genotype-phenotype correlation and in silico modeling analysis.

Pediatr Dermatol 2019 Jan 4;36(1):132-138. Epub 2018 Dec 4.

Epidermolysis Bullosa Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background/objectives: Epidermolysis bullosa is a group of diseases caused by mutations in skin structural proteins. Availability of genetic sequencing makes identification of causative mutations easier, and genotype-phenotype description and correlation are important. We describe six patients with a keratin 5 mutation resulting in a glutamic acid to lysine substitution at position 477 (p. Read More

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http://dx.doi.org/10.1111/pde.13722DOI Listing
January 2019
1 Read

Aluminum granuloma in a child secondary to DTaP-IPV vaccination: A case report.

Pediatr Dermatol 2019 Jan 28;36(1):e17-e19. Epub 2018 Nov 28.

Department of Dermatology, Oregon Health & Science University, Portland, Oregon.

Reports detailing the acute formation of aluminum granulomas, which can cause persistent, intensely pruritic nodules secondary to the administration of aluminum-containing vaccines, are infrequently described in medical literature. To our knowledge, this is the first report describing the development of an aluminum granuloma causing a persistent, pruritic nodule at the injection site following the administration of the DTaP-IPV vaccine. We present the case of a 6-year-old girl who developed a severely pruritic subcutaneous nodule on her anterior right thigh at the injection site three weeks after the administration of the aluminum-containing DTaP-IPV (Kinrix) vaccine. Read More

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http://doi.wiley.com/10.1111/pde.13732
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http://dx.doi.org/10.1111/pde.13732DOI Listing
January 2019
26 Reads

Characteristics of persistent diaper dermatitis in children with food allergy.

Pediatr Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pediatrics, Medical Faculty, Inonu University, Malatya, Turkey.

Background/objectives: Diaper dermatitis is often caused by irritant contact occurring beneath the diaper of an infant, and it is aggravated by factors such as dampness, friction, urea, and feces. Food-allergic patients are known to exhibit various skin lesions ranging from urticaria to eczema. This study aims to determine the relationship between persistent diaper dermatitis and food allergy. Read More

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http://dx.doi.org/10.1111/pde.13733DOI Listing
November 2018
2 Reads

Linear lipoatrophy following intra-articular triamcinolone acetonide injection mimicking linear scleroderma.

Pediatr Dermatol 2019 Jan 28;36(1):e56-e57. Epub 2018 Nov 28.

Division of Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.

A 12-year-old female with oligoarticular juvenile inflammatory arthritis developed an atrophic linear plaque involving the left medial forearm and proximal arm 7 months after intra-articular triamcinolone injection for arthritis. The plaque spontaneously resolved without treatment over approximately one year. It is important to recognize this rare complication of intra-articular steroid injection in order to avoid potential misdiagnosis as linear scleroderma and subsequent immunosuppressive treatment. Read More

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http://dx.doi.org/10.1111/pde.13736DOI Listing
January 2019
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Severe vemurafenib-induced photosensitivity in a 6-year-old boy.

Pediatr Dermatol 2019 Jan 26;36(1):e62-e63. Epub 2018 Nov 26.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Vemurafenib, a selective BRAF kinase inhibitor, has been found to induce several cutaneous adverse effects, ranging from a keratosis pilaris-like reaction to squamous cell carcinoma. While photosensitivity has been well described as one of these manifestations, we report a case of a 6-year-old boy on vemurafenib who developed a severe blistering sunburn after only two 30-minute episodes of sun exposure. A brief review of other common cutaneous adverse effects of vemurafenib is also provided. Read More

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http://dx.doi.org/10.1111/pde.13720DOI Listing
January 2019
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Treatment of oral manifestations of toxic epidermal necrolysis with low-level laser therapy in a pediatric patient.

Pediatr Dermatol 2019 Jan 26;36(1):e27-e30. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

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http://doi.wiley.com/10.1111/pde.13719
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http://dx.doi.org/10.1111/pde.13719DOI Listing
January 2019
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Glycopyrronium tosylate in pediatric primary axillary hyperhidrosis: Post hoc analysis of efficacy and safety findings by age from two phase three randomized controlled trials.

Pediatr Dermatol 2019 Jan 19;36(1):89-99. Epub 2018 Nov 19.

Eastern Virginia Medical School and Virginia Clinical Research, Inc., Norfolk, Virginia.

Objectives: Hyperhidrosis in pediatric patients has been understudied. Post hoc analyses of two phase 3 randomized, vehicle-controlled, 4-week trials (ATMOS-1 [NCT02530281] and ATMOS-2 [NCT02530294]) were performed to assess efficacy and safety of topical anticholinergic glycopyrronium tosylate (GT) in pediatric patients.

Methods: Patients had primary axillary hyperhidrosis ≥ 6 months, average Axillary Sweating Daily Diary (ASDD/ASDD-Children [ASDD-C]) Item 2 (sweating severity) score ≥ 4, sweat production ≥ 50 mg/5 min (each axilla), and Hyperhidrosis Disease Severity Scale (HDSS) ≥ 3. Read More

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http://dx.doi.org/10.1111/pde.13723DOI Listing
January 2019
10 Reads