2,666 results match your criteria Pediatric Allergy and Immunology[Journal]


Parent and child perception of quality of life in a randomized controlled peanut oral immunotherapy trial.

Pediatr Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Background: Improved quality of life (QoL) after oral immunotherapy (OIT) in peanut allergic children is often reported by their parents, while the child's perspective is less clear.

Objective: We aimed to explore if two years of OIT improved QoL in children with peanut allergy and to identify factors influencing change in QoL.

Methods: In the open labelled TAKE-AWAY peanut OIT trial including children with anaphylaxis to peanuts, 57 were randomized to OIT and 20 to observation. Read More

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http://dx.doi.org/10.1111/pai.13066DOI Listing

Recombinant Human C1 Esterase Inhibitor Treatment for Hereditary Angioedema Attacks in Children.

Pediatr Allergy Immunol 2019 Apr 16. Epub 2019 Apr 16.

Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1-INH-HAE) usually begin during childhood or adolescence. However, limited data are available regarding indications and modalities of treatment of children. This study evaluated recombinant human C1-INH (rhC1-INH) for HAE attacks in children. Read More

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http://dx.doi.org/10.1111/pai.13065DOI Listing
April 2019
4 Reads

Short-term exposure to ultrafine particles is associated to bronchial inflammation in schoolchildren.

Pediatr Allergy Immunol 2019 Apr 15. Epub 2019 Apr 15.

Faculté de Pharmacie de Paris, Inserm U1153-CRESS HERA Team, Université Paris Descartes, France.

Ultrafine particles (UFP, particulate matter PM<100 nm), through their small size, high number and surface area, and their chemical composition , can induce serious health effects . UFP are able to reach lung alveoli and are toxic through mechanisms of oxidative stress, cell signalling and activation, and release of mediators initiating inflammatory processes in the respiratory tract and in the cardio-vascular system . This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/pai.13064DOI Listing
April 2019
1 Read

Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.

Pediatr Allergy Immunol 2019 Apr 15. Epub 2019 Apr 15.

Telethon Kids Institute, University of Western Australia, WA, Australia.

Background: Antigen specific IgE binds the Fcε receptor I (FcεRI) expressed on several types of immune cells, including dendritic cells (DC). Activation of FcεRI on DCs in atopics has been shown to modulate immune responses that potentially contribute to asthma development. However, the extent to which DC subsets differ in FcεRI expression between atopic children with or without asthma is currently not clear. Read More

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http://dx.doi.org/10.1111/pai.13063DOI Listing

Linking COPD epidemiology with pediatric asthma care; implications for the patient and the physician.

Pediatr Allergy Immunol 2019 Apr 10. Epub 2019 Apr 10.

Translational Medicine, Hospital for Sick Children, Toronto, Canada.

A 10-year-old patient with asthma, diagnosed in early childhood, with a pre-bronchodilator forced expiratory volume in 1 second (FEV1) of 75% of predicted attends a routine follow-up visit. The patient and family perceive his asthma as 'well controlled', but should his physician be concerned about his reduced lung function? What are the implications of a lower than expected FEV1 in childhood on the respiratory health of this patient in adulthood? Lung function is known to track with age, and there is a high likelihood that this patient will enter adulthood with a sub-optimal lung function. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/pai.13054DOI Listing

Allergen-specific immunotherapy enhances CD8 CD25 CD137 regulatory T cells and decreases nasal nitric oxide.

Pediatr Allergy Immunol 2019 Apr 9. Epub 2019 Apr 9.

Clinical Immunological Center, China Medical University Hospital, College of Medicine, China Medical University, Taichung, Taiwan.

Background: 4-1BB (CD137), a member of the inducible tumor necrosis factor receptor (TNFR) family, is expressed on regulatory T (Treg) cells and regulates Treg cells to control allergic inflammation. Pam3CSK4, a synthetic TLR2 ligand that can expand CD8+ Treg function, is a promising adjuvant for allergen immunotherapy (IT). We examined whether Dermatophagoides pteronyssinus (Der p) IT and Pam3CSK4 could enhance CD8+CD25+CD137+ Treg suppressive function to decrease nasal nitric oxide (nNO) levels. Read More

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http://dx.doi.org/10.1111/pai.13061DOI Listing
April 2019
1 Read

A Randomized Trial of human C1 inhibitor prophylaxis in children with hereditary angioedema.

Pediatr Allergy Immunol 2019 Apr 9. Epub 2019 Apr 9.

HRZM Hemophilie Center Rhein Main, Mörfelden-Walldorf, Germany.

Background: Patients with hereditary angioedema with C1 inhibitor deficiency or dysfunction have burdensome recurrent angioedema attacks. The safety, efficacy, and health-related quality of life (HRQoL) outcomes of C1 inhibitor (C1-INH) prophylaxis (intravenously administered) in patients aged 6-11 years were investigated.

Methods: Eligible patients were enrolled in a randomized, single-blind, crossover phase 3 trial. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13060
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http://dx.doi.org/10.1111/pai.13060DOI Listing
April 2019
5 Reads

A case-series of pediatric oncology patients undergoing successful rapid etoposide desensitization.

Pediatr Allergy Immunol 2019 Apr 9. Epub 2019 Apr 9.

Section of Immunology, Allergy and Rheumatology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.

Etoposide is a podophyllotoxin used in the treatment of various pediatric neoplasms. Hypersensitivity reactions (HSR) to etoposide have a reported incidence of about 1-3%, with symptoms ranging from mild cutaneous reactions to fatal anaphylaxis. HSR to etoposide are thought to be related to the vehicle used to dissolve etoposide, polysorbate 80, rather than the drug. Read More

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http://dx.doi.org/10.1111/pai.13059DOI Listing
April 2019
1 Read

Hypersensitivity reactions to antiepileptic drugs in children.

Pediatr Allergy Immunol 2019 Apr 5. Epub 2019 Apr 5.

University of Belgrade-Faculty of Medicine, Belgrade, Serbia.

Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting and benign but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. Read More

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http://dx.doi.org/10.1111/pai.13055DOI Listing
April 2019
2 Reads

Early oral immunotherapy in infants with cow's milk protein allergy.

Pediatr Allergy Immunol 2019 Apr 4. Epub 2019 Apr 4.

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.

Cow's milk allergy (CMA) is the most frequent food allergy in the first years of life, with prevalence rates estimated in the range of 2-3% [1,2]. With the aim of reducing the risk of allergic reactions for accidental exposures to cow's milk (CM) proteins and of favouring the regain of clinical tolerance, strategies of controlled oral exposure to CM have been developed as immunotherapy for the treatment of children with established food allergy [3-5]. However, available data on the use of oral immunotherapy in infants with food allergy are very limited. Read More

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http://dx.doi.org/10.1111/pai.13057DOI Listing
April 2019
6 Reads

Intrauterine Detection of DCLRE1C (Artemis) Mutation by Restriction Fragment Length Polymorphism.

Pediatr Allergy Immunol 2019 Apr 4. Epub 2019 Apr 4.

Necmettin Erbakan University, Meram Medical Faculty, Department of Pediatric Allergy and Immunology, 42080, Konya, Turkey.

Non-homologousendjoining (NHEJ) plays an important role in V(D)J recombination of the immunoglobulin and T-cell receptor genes during the Tand Bcell development . Defects in components of theNHEJDNA repairmechanismseverelyimpairthedevelopment of TandB lymphocytesandleadto a T-B-NK+ severe combinedimmunodeficiency(SCID) characterizedbyincreasedsensitivitytoionizedradiation . This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/pai.13056DOI Listing
April 2019
2 Reads

Nutrition and allergic diseases in urban and rural communities from the South African Food Allergy (SAFFA) cohort.

Pediatr Allergy Immunol 2019 Apr 4. Epub 2019 Apr 4.

Division of Paediatric Allergy, Department of Paediatrics, University of Cape Town, Cape Town, South Africa.

This study describes and compares allergic diseases and sensitisation in urban and rural children in the SAFFA study cohort as well as infant feeding patterns and nutritional status. We assessed the relationship between nutritional status, breastfeeding, complementary feeding patterns and atopic diseases including aero- and food allergen sensitisation, self-reported atopic dermatitis, allergic rhinitis, asthma, and challenge proven food allergy.

Methodology: 1185 urban and 398 rural toddlers aged 12-36 months were screened for food sensitisation and food allergy using skin prick testing and oral food challenges. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13058
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http://dx.doi.org/10.1111/pai.13058DOI Listing
April 2019
3 Reads

Reply to Dr. Yarandi.

Pediatr Allergy Immunol 2019 Mar 27. Epub 2019 Mar 27.

Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Department of Gastroenterology, Children's Hospital of Chongqing Medical University, Chongqing, China.

We would like to thank Dr. Yarandi (1) for his interest in our systematic review of the diagnostic value of atopy patch test (APT) in food allergy in children (2), and for taking the time to express his concerns about the methodology of our paper. We agree that adherence to a review protocol can reduce the risk of bias in the systematic review. Read More

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http://dx.doi.org/10.1111/pai.13053DOI Listing

Association of antimicrobial household exposure with development of allergic rhinitis in Korea.

Pediatr Allergy Immunol 2019 Mar 12. Epub 2019 Mar 12.

Department of Environmental Health Research, Seoul Medical Center, Seoul, South Korea.

Antimicrobial chemicals are used in consumer products. Typical antimicrobial chemicals include triclosan (TCS) and its congener troclocarban (TCC). TCS exhibits endocrine-disruptor activity and affects thyroid hormone and estrogen and androgen levels. Read More

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http://dx.doi.org/10.1111/pai.13052DOI Listing
March 2019
2 Reads
3.397 Impact Factor

Oral challenge without skin testing in children with suspected non-severe betalactam hypersensitivity.

Pediatr Allergy Immunol 2019 Feb 28. Epub 2019 Feb 28.

Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, CHU Lille, Lille, France.

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http://dx.doi.org/10.1111/pai.13048DOI Listing
February 2019

Anaphylaxis after Elosulfase A infusion: Omalizumab as coadyuvant for enzyme replacement therapy desensitization.

Pediatr Allergy Immunol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, Complejo Hospitalario de Navarra. C/ Irunlarrea 4. Planta Baja. Pamplona., 31008, Spain.

Type IV A Mucopolysaccharidosis (MPS IV A) is a lysosomal storage disease caused by an autosomal recessive mutation in the gene encoding the enzyme galactosamine-6-sulfatase, which catalyses the degradation of glycosaminoglycans (GAGs). It leads to the accumulation of GAGs keratan sulfate. Symptoms include skeletal dysplasia, atlantoaxial instability, pectus carinatum, short stature, laxity of joints, cervical spinal cord compression, cardiac and pulmonary complications, corneal opacity, impaired hearing but normal cognitive development. Read More

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http://dx.doi.org/10.1111/pai.13049DOI Listing
February 2019
2 Reads

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children.

Pediatr Allergy Immunol 2019 Feb 25. Epub 2019 Feb 25.

Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background: Immunomodulatory effects of sublingual immunotherapy on systemic and mucosal mediators in allergic children are largely unexplored. The aim of this study was to investigate allergy-related cytokine and chemokine levels, as well as IgA-responses upon a 3-year treatment with timothy grass pollen sublingual immunotherapy in children with allergic rhinoconjunctivitis.

Methods: From children included in the GRAZAX Asthma Prevention study, blood and saliva samples were analyzed at inclusion, after 3 years of treatment, and 2 years after treatment ending. Read More

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http://dx.doi.org/10.1111/pai.13047DOI Listing
February 2019

The First Cohort of Iranian Patients with Hyper Immunoglobulin E Syndrome: A Long-Term Follow-up and Genetic Analysis.

Pediatr Allergy Immunol 2019 Feb 23. Epub 2019 Feb 23.

Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hyper IgE syndromes (HIES) are distinct disease characterized by recurrent cutaneous and lung infections, eczema and elevated serum IgE level.

Methods: In this study, clinical manifestations, immunologic findings and genetic studies of all patients with HIES in the Iranian national registry database were evaluated.

Results: 129 HIES patients with median age of 14. Read More

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http://dx.doi.org/10.1111/pai.13043DOI Listing
February 2019
1 Read
3.397 Impact Factor

Do traditional fermented foods protect against infantile atopic dermatitis.

Pediatr Allergy Immunol 2019 Feb 23. Epub 2019 Feb 23.

Department of Biostatistics, Trakya University Faculty of Medicine, Edirne, Turkey.

Background: Environmental and dietary factors during pregnancy may affect development of infantile atopic dermatitis (AD). This study analyzed whether maternal consumption of selected Turkish fermented foods (FF) and other factors during pregnancy affect the development of AD during the first 2 years of life.

Methods: Eighty-four children with physician-diagnosed AD (aged between 2 and 24 months) and mothers, and 56 similarly aged, healthy children and mothers were studied. Read More

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http://dx.doi.org/10.1111/pai.13045DOI Listing
February 2019
1 Read

Fetal umbilical, cerebral and pulmonary blood flow patterns in relation to lung function and asthma in childhood. The Generation R Study.

Pediatr Allergy Immunol 2019 Feb 23. Epub 2019 Feb 23.

Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the Netherlands.

Background: Fetal growth restriction is associated with higher risks of childhood respiratory morbidity. Fetal blood flow adaptations might contribute to these associations. We examined the associations of fetal umbilical, cerebral, and pulmonary blood flow with wheezing patterns, lung function, and asthma in childhood. Read More

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http://dx.doi.org/10.1111/pai.13044DOI Listing
February 2019
3 Reads

The diagnostic value of APT for food allergy in children: a systematic review and meta-analysi.

Pediatr Allergy Immunol 2019 Feb 23. Epub 2019 Feb 23.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

I read the interesting review study by Ying Luo et al.[1] published in The Journal of Pediatric Allergy and Immunology. I used 16-item AMSTAR2 [2] appraisal tool to assess methodological quality of this review. Read More

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http://dx.doi.org/10.1111/pai.13046DOI Listing
February 2019

A cross-sectional, population-based study on the prevalence of food allergies among children in two different socio-economic regions of Vietnam.

Pediatr Allergy Immunol 2019 Feb 21. Epub 2019 Feb 21.

Molecular Allergy Research Laboratory, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia.

Background: There is a paucity of data on the prevalence of food allergy (FA) in Vietnam. A cross-sectional, population-based study was conducted to evaluate the current prevalence of FA among 2- to 6-year-old children in two different regions in Vietnam.

Method: A structured, anonymous questionnaire, modified from published FA epidemiologic studies and based on EAACI guidelines, was distributed to parents/guardians of participating children in Hue City (urban area) and Tien Giang Province (rural area). Read More

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http://dx.doi.org/10.1111/pai.13022DOI Listing
February 2019
2 Reads

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial.

Pediatr Allergy Immunol 2019 Feb 21. Epub 2019 Feb 21.

Hans Christian Andersen Hospital for Children and Adolescents, Odense University Hospital, Odense C, Denmark.

Background: Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization.

Methods: In this double-blind, placebo-controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis or placebo-starting prior to attending day care. Read More

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http://dx.doi.org/10.1111/pai.13018DOI Listing
February 2019
1 Read

The environment and its effect on allergic sensitization and atopic dermatitis, and colostrum and the immune system of the preterm infant.

Pediatr Allergy Immunol 2019 03;30(2):147-148

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1111/pai.13029DOI Listing

Allergen immunotherapy for IgE-mediated food allergy: There is a measure in everything to a proper proportion of therapy.

Pediatr Allergy Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatric Medicine, Pediatric Allergology Unit, Bambino Gesù Children's research Hospital (IRCCS), Rome, Italy.

IgE-mediated food allergy (FA) is a potentially life-threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (eg, milk, egg, and peanut). Read More

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http://doi.wiley.com/10.1111/pai.13042
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http://dx.doi.org/10.1111/pai.13042DOI Listing
February 2019
4 Reads

MAIT cells, TCR γδ+ cells and ILCs cells in human breast milk and blood from HIV infected and uninfected women.

Pediatr Allergy Immunol 2019 Feb 13. Epub 2019 Feb 13.

Pathogenesis and Control of Chronic Infections, Inserm U1058, Université de Montpellier and CHU de Montpellier, Montpellier, France.

Background: Human breast milk cells remain poorly characterized for the presence of unconventional T lymphocytes and innate lymphoid cells (ILCs).

Methods: Early breast milk was collected from eight HIV-uninfected and 11 HIV-infected women 3-12 days after delivery. Mucosal-associated invariant T cells (MAIT cells), TCR γδ cells, and innate lymphoid cells (ILCs) were analyzed in breast milk and paired blood samples. Read More

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http://dx.doi.org/10.1111/pai.13037DOI Listing
February 2019

Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective.

Pediatr Allergy Immunol 2019 Feb 11. Epub 2019 Feb 11.

CHU Clermont-Ferrand. Consultation d'Ophtalmologie et Allergologie de l'enfant, Unité d'Allergologie de l'enfant, CHU Estaing, 63003, Clermont-Ferrand Cedex1, France.

Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. Read More

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http://dx.doi.org/10.1111/pai.13035DOI Listing
February 2019
9 Reads

MicroRNA-181a and microRNA-155 are involved in the regulation of the differentiation and function of regulatory T cells in allergic rhinitis children.

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

Department of Respiratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China.

Background: Regulatory T cells (Tregs) play central roles in limiting airway allergic inflammation and preventing inappropriate Th2 responses to environmental allergens. This study aims to evaluate the role of miR-181a and miR-155 in the regulation of the differentiation and function of Tregs through both in vivo and in vitro studies.

Methods: The CD4 T cells and Tregs were purified from peripheral blood mononuclear cells (PBMCs) in allergic rhinitis (AR) children, respectively. Read More

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http://dx.doi.org/10.1111/pai.13038DOI Listing
February 2019
2 Reads

Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases.

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.

Background: Allergies are a serious public health issue, and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- and post-natal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). Read More

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http://doi.wiley.com/10.1111/pai.13039
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http://dx.doi.org/10.1111/pai.13039DOI Listing
February 2019
18 Reads

Skin tests are important in children with β-lactam hypersensitivity, but may be reduced in number.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Allergy Unit, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, CHU de Montpellier, Univ Montpellier, Montpellier, France.

Background: There is no perfect agreement on how to perform an allergy workup in suspected beta-lactam (BL)-allergic children, since skin test (ST)-induced pain is often a limitation. The aim of the study was to assess the possibility of reducing the number of ST in children when performing a complete allergy workup for BL hypersensitivity reactions.

Methods: A retrospective analysis of all patients referring to the Allergy Unit of the University Hospital of Montpellier (France) with positive responses in immediateand non-immediate-reading ST to a BL over a 16-year period was performed, to determine the positive predictive value (PPV) of ST. Read More

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http://dx.doi.org/10.1111/pai.13041DOI Listing
February 2019
3 Reads

Interleukin-33 in the developing lung-Roles in asthma and infection.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.

It has become increasingly clear that interleukin-33 (IL-33) plays a crucial role in initiation of type 2 immunity. The last decade of intense research has uncovered multiple mechanisms through which IL-33 targets key effector cells of the allergic immune response. Recently, IL-33 has been implicated in shaping the immune system of the lungs early in life, at a time which is crucial in the subsequent development of allergic asthma. Read More

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http://doi.wiley.com/10.1111/pai.13040
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http://dx.doi.org/10.1111/pai.13040DOI Listing
February 2019
3 Reads

Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatric Pneumology and Immunology, Charite Medical University, Berlin, Germany.

Background: Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. Read More

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http://dx.doi.org/10.1111/pai.13036DOI Listing
February 2019
7 Reads

Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Geneva University Hospitals, Department of child and adolescent, Pediatric Allergy Unit, Geneva, Switzerland.

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Read More

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http://dx.doi.org/10.1111/pai.13034DOI Listing
February 2019
2 Reads

Clinical and genetic characteristics of Chinese pediatric patients with chronic granulomatous disease.

Pediatr Allergy Immunol 2019 Feb 4. Epub 2019 Feb 4.

China National Clinical Research Center for Respiratory Diseases, Beijing, China.

Background: Chronic granulomatous disease (CGD) is a rare disease in China, and very little large-scale studies have been conducted to date. We aimed to investigate the clinical and genetic features of CGD in Chinese pediatric patients.

Methods: Pediatric patients with CGD from Beijing Children's Hospital, Capital Medical University, China, were enrolled from January 2006 to December 2016. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13033
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http://dx.doi.org/10.1111/pai.13033DOI Listing
February 2019
3 Reads
3.397 Impact Factor

The diagnostic value of APT for food allergy in children: a systematic review and meta-analysis.

Pediatr Allergy Immunol 2019 Jan 31. Epub 2019 Jan 31.

Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Department of Gastroenterology, Children's Hospital of Chongqing Medical University, Chongqing, China.

Background: The role of atopy patch test (APT) in the diagnosis of food allergy (FA) remains largely controversial. In our meta-analysis, we aimed to evaluate the accuracy of APT for diagnosing FA in children.

Methods: Pubmed, Embase and Cochrane Library were searched for studies regarding the diagnostic value of APT for FA in children compared to oral food challenge (double-blind placebo-controlled food challenge and/or open food challenge). Read More

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http://dx.doi.org/10.1111/pai.13031DOI Listing
January 2019
4 Reads

Guidance for assessment of erythroderma in neonates and infants for the pediatric immunologist.

Authors:
Hagen Ott

Pediatr Allergy Immunol 2019 Jan 31. Epub 2019 Jan 31.

Division of Pediatric Dermatology, Children's Hospital AUF DER BULT, Hannover, Germany.

Neonatal and infantile erythroderma (NIE) represents the common clinical phenotype of heterogeneous diseases ranging from benign and transient skin conditions to fatal multiorgan disorders. NIE regularly demands a comprehensive diagnostic workup in a multiprofessional setting, especially if newborns and young infants with the disease develop a failure to thrive and concomitant infectious, neurologic, or metabolic complications. By obtaining a detailed medical history and performing a thorough clinical examination, targeted diagnostic steps can be scheduled for most affected children. Read More

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http://dx.doi.org/10.1111/pai.13032DOI Listing
January 2019
6 Reads

"Molecular extracts" for allergy diagnostics and therapy.

Pediatr Allergy Immunol 2019 02;30(1):55-58

Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany.

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http://doi.wiley.com/10.1111/pai.13001
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http://dx.doi.org/10.1111/pai.13001DOI Listing
February 2019
5 Reads

On early metabolite exposure influencing asthma outcome, the risk of hymenoptera allergy in a birth cohort, and improvement of food allergy management at school.

Pediatr Allergy Immunol 2019 02;30(1):5-6

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1111/pai.13014DOI Listing
February 2019

Serum thymus and activation-regulated chemokine level as a potential biomarker for food protein-induced enterocolitis syndrome.

Pediatr Allergy Immunol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.

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http://dx.doi.org/10.1111/pai.13030DOI Listing
January 2019
1 Read

Outcome of oral immunotherapy for persistent cow's milk allergy from 11 years of experience in Finland.

Pediatr Allergy Immunol 2019 Jan 27. Epub 2019 Jan 27.

Helsinki University Hospital, Skin and Allergy Hospital, Helsinki, Finland.

Background: The safety and efficacy of long-term milk oral immunotherapy (OIT) in Finnish children with persistent cow's milk allergy (CMA) were evaluated in an open-label, non-randomized study.

Methods: During the 11-year study, 296 children aged 5 years or older with immunoglobulin E (IgE)-mediated CMA started milk OIT. Follow-up data were collected at three time points: the post-buildup phase, 1 year thereafter, and at the cross-sectional long-term follow-up between January 2016 and December 2017. Read More

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http://dx.doi.org/10.1111/pai.13025DOI Listing
January 2019
7 Reads

Detection of local allergic rhinitis in children with chronic, difficult-to-treat, non-allergic rhinitis using multiple nasal provocation tests.

Pediatr Allergy Immunol 2019 Jan 27. Epub 2019 Jan 27.

Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.

Background: There is little evidence on the incidence and characteristics of local allergic rhinitis (LAR) in children. Most studies have included subjects with perennial rhinitis only, and results are based on the investigation of no more than three allergens per study. Our aim was to determine the proportion of children with LAR amongst children with chronic, difficult-to-treat, perennial or seasonal, rhinitis but no evidence of sensitization to aeroallergens, or other alternative diagnosis. Read More

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http://dx.doi.org/10.1111/pai.13021DOI Listing
January 2019
3 Reads

Ataxia-telangiectasia: A review of clinical features and molecular pathology.

Pediatr Allergy Immunol 2019 Jan 27. Epub 2019 Jan 27.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, Iran.

Ataxia-telangiectasia (A-T) is an autosomal recessive primary immunodeficiency (PID) disease that is caused by mutations in ataxia-telangiectasia mutated (ATM) gene encoding a serine/threonine protein kinase. A-T patients represent a broad range of clinical manifestations including progressive cerebellar ataxia, oculocutaneous telangiectasia, variable immunodeficiency, radiosensitivity, susceptibility to malignancies, and increased metabolic diseases. This congenital disorder has phenotypic heterogeneity, and the severity of symptoms varies in different patients based on severity of mutations and disease progression. Read More

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http://dx.doi.org/10.1111/pai.13020DOI Listing
January 2019
2 Reads
3.397 Impact Factor

Using only a subset of pneumococcal serotypes is reliable for the diagnosis of specific antibody deficiency in children: A proof-of-concept study.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1111/pai.13026DOI Listing
January 2019
2 Reads

Allergy screening in a schoolchildren-based population.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Department of Sense Organs, University Sapienza of Rome, Rome, Italy.

Background: Schoolchildren screening for allergic diseases may improve early identification and management of atopic children. The aim of this study was to perform a schoolchildren screening program for identification of children with allergic diseases.

Methods: All parents of children attending to 13 primary schools in the city of Rome were requested to fill in a demographic data form and the ChAt questionnaire. Read More

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http://dx.doi.org/10.1111/pai.13024DOI Listing
January 2019
2 Reads

Differentially methylated DNA regions in early childhood wheezing: An epigenome-wide study using saliva.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.

Background: Epigenetics may play a role in wheezing and asthma development. We aimed to examine infant saliva DNA methylation in association with early childhood wheezing.

Methods: A case-control study was nested within the NINFEA birth cohort with 68 cases matched to 68 controls by sex, age (between 6 and 18 months, median: 10. Read More

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http://dx.doi.org/10.1111/pai.13023DOI Listing
January 2019
11 Reads
3.397 Impact Factor

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

INSERM UMR 1153 - CRESS, HERA (Health Environmental Risk Assessment) research unit, Université Paris Descartes - Sorbonne Paris Cité, Paris, France.

Background: Natural course and co-occurrence of asthma, eczema, and allergic rhinitis through childhood are still not fully documented. We aim to identify and characterize profiles based on the time course, severity, and apparent triggers of respiratory/allergy symptoms in school-aged children.

Methods: Data on occurrence, severity, and triggers of asthma, rhinitis, and dermatitis symptoms were collected annually during the follow-up of the PARIS birth cohort. Read More

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http://dx.doi.org/10.1111/pai.13027DOI Listing
January 2019
3 Reads

Impact of food allergy on food insecurity and health literacy in a tertiary care pediatric allergy population.

Pediatr Allergy Immunol 2019 Jan 23. Epub 2019 Jan 23.

University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: Food insecurity (FI), limited availability of or access to nutritional foods, is linked to poor child/caregiver health. We examined FI in food-allergic and non-food-allergic children to determine whether dietary limitations associated with food allergy increases risk of FI.

Methods: Food-allergic and non-food-allergic children (1-17 years) were recruited from Arkansas Children's Hospital allergy/asthma clinics. Read More

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http://dx.doi.org/10.1111/pai.13019DOI Listing
January 2019
1 Read

Evaluation of the efficiency of hydrolyzed whey formula to prevent cow's milk allergy in the BALB/c mouse model.

Pediatr Allergy Immunol 2019 Jan 23. Epub 2019 Jan 23.

Laboratoire d'Immuno-Allergie Alimentaire, UMR Service de Pharmacologie et d'Immunoanalyse, CEA, INRA, Université Paris-Saclay, Gif-sur-Yvette, France.

Background: Partially hydrolyzed milk formulas have been proposed for primary prevention in at-risk infants, but evidence of their efficiency and elucidation of the underlying mechanisms are still lacking. Thanks to a Th2-biased mouse model mimicking at-risk patients, we aimed to assess the potency of a partially hydrolyzed whey formula (pHWF) to induce oral tolerance thus preventing further cow's milk (CM) allergy.

Methods: BALB/c mice were gavaged with pHWF, standard milk formula (SF), or vehicle only (PBS+). Read More

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http://dx.doi.org/10.1111/pai.13017DOI Listing
January 2019
3 Reads