2,642 results match your criteria Pediatric Allergy and Immunology[Journal]


The environment and its effect on allergic sensitization and atopic dermatitis, and colostrum and the immune system of the preterm infant.

Pediatr Allergy Immunol 2019 Mar;30(2):147-148

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1111/pai.13029DOI Listing

Allergen Immunotherapy for IgE-Mediated Food Allergy: there is a measure in everything to a proper proportion of therapy.

Pediatr Allergy Immunol 2019 Feb 15. Epub 2019 Feb 15.

Pediatric Allergology Unit, Department of Pediatric Medicine, Bambino Gesù Children's research Hospital (IRCCS), Rome, Holy See, Italy.

IgE-mediated food allergy (FA) is a potentially life-threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (e. Read More

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http://doi.wiley.com/10.1111/pai.13042
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http://dx.doi.org/10.1111/pai.13042DOI Listing
February 2019
4 Reads

MAIT cells, TCR γδ+ cells and ILCs cells in human breast milk and blood from HIV infected and uninfected women.

Pediatr Allergy Immunol 2019 Feb 13. Epub 2019 Feb 13.

Pathogenesis and Control of Chronic Infections, Inserm U1058, Université de Montpellier; and CHU de Montpellier, France.

Background: Human breast milk cells remains poorly characterised for the presence of unconventional T lymphocytes and innate lymphoid cells (ILCs).

Methods: Early breast milk were collected from eight HIV-uninfected and eleven HIV infected women three to twelve days after delivery. Mucosal associated innate lymphocytes (MAIT cells), TCR γδ cells, and innate lymphoid cells (ILCs) were analyzed in breast milk and paired blood samples. Read More

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http://dx.doi.org/10.1111/pai.13037DOI Listing
February 2019

Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective.

Pediatr Allergy Immunol 2019 Feb 11. Epub 2019 Feb 11.

CHU Clermont-Ferrand. Consultation d'Ophtalmologie et Allergologie de l'enfant, Unité d'Allergologie de l'enfant, CHU Estaing, 63003, Clermont-Ferrand Cedex1, France.

Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. Read More

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http://dx.doi.org/10.1111/pai.13035DOI Listing
February 2019
1 Read

MicroRNA-181a and microRNA-155 are involved in the regulation of the differentiation and function of regulatory T cells in allergic rhinitis children.

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

Department of Respiratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China.

Background: Regulatory T cells (Tregs) play central roles in limiting airway allergic inflammation and preventing inappropriate Th2 responses to environmental allergens. This study aims to evaluate the role of miR-181a and miR-155 in the regulation of the differentiation and function of Tregs through both in vivo and in vitro studies.

Methods: The CD4 T cell and Tregs were purified from peripheral blood mononuclear cells (PBMCs) in allergic rhinitis (AR) children, respectively. Read More

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http://dx.doi.org/10.1111/pai.13038DOI Listing
February 2019
1 Read

Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases.

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

University Children's Hospital Zurich, Switzerland.

Background: Allergies are a serious public health issue and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- & postnatal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). Read More

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http://doi.wiley.com/10.1111/pai.13039
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http://dx.doi.org/10.1111/pai.13039DOI Listing
February 2019
3 Reads

Skin tests are important in children with β-lactam hypersensitivity, but may be reduced in number.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Allergy Unit, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, CHU de Montpellier, Univ Montpellier, France.

There is no perfect agreement on how to perform an allergy work-up in suspected beta-lactam (BL) allergic children, since skin test (ST)-induced pain is often a limitation. The aim of the study was to assess the possibility of reducing the number of ST in children when performing a complete allergy work-up for BL hypersensitivity reactions. A retrospective analysis of all patients referring to the Allergy Unit of the University Hospital of Montpellier (France) with positive responses in immediate- and non-immediate-reading ST to a BL over a 16-years period was performed, to determine the positive predictive value (PPV) of ST. Read More

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http://dx.doi.org/10.1111/pai.13041DOI Listing
February 2019
1 Read

IL-33 in the developing lung - roles in asthma and infection.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.

It has become increasingly clear that interleukin-33 (IL-33) plays a crucial role in initiation of type 2 immunity. The last decade of intense research has uncovered multiple mechanisms through which IL-33 targets key effector cells of the allergic immune response. Recently, IL-33 has been implicated in shaping the immune system of the lungs early in life, at a time which is crucial in the subsequent development of allergic asthma. Read More

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http://dx.doi.org/10.1111/pai.13040DOI Listing
February 2019

Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatric Pneumology and Immunology, Charite Medical University, Berlin, Germany.

Background: Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. Read More

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http://dx.doi.org/10.1111/pai.13036DOI Listing
February 2019
3 Reads

Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Geneva University Hospitals, Department of child and adolescent, Pediatric Allergy Unit, Geneva, Switzerland.

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Read More

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http://dx.doi.org/10.1111/pai.13034DOI Listing
February 2019
1 Read

Clinical and Genetic characteristics of Chinese Pediatric Patients with Chronic Granulomatous Disease.

Pediatr Allergy Immunol 2019 Feb 4. Epub 2019 Feb 4.

China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, 100045.

Background: Chronic granulomatous disease (CGD) is a rare disease in China, and very little large-scale studies have been conducted to date. We aimed to investigate the clinical and genetic features of CGD in Chinese pediatric patients.

Methods: Pediatric patients with CGD from Beijing Children's Hospital, Capital Medical University, China were enrolled from January 2006 to December 2016. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13033
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http://dx.doi.org/10.1111/pai.13033DOI Listing
February 2019
2 Reads
3.397 Impact Factor

The diagnostic value of APT for food allergy in children: a systematic review and meta-analysis.

Pediatr Allergy Immunol 2019 Jan 31. Epub 2019 Jan 31.

Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Department of Gastroenterology, Children's Hospital of Chongqing Medical University, Chongqing, China.

Background: The role of atopy patch test (APT) in the diagnosis of food allergy (FA) remains largely controversial. In our meta-analysis, we aim to evaluate the accuracy of APT for diagnosing FA in children.

Methods: Pubmed, Embase and Cochrane Library were searched for studies regarding the diagnostic value of APT for FA in children compared to oral food challenge (double-blind placebo-controlled food challenge and/or open food challenge). Read More

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http://dx.doi.org/10.1111/pai.13031DOI Listing
January 2019

Guidance for assessment of erythroderma in neonates and infants for the pediatric immunologist.

Authors:
Hagen Ott

Pediatr Allergy Immunol 2019 Jan 31. Epub 2019 Jan 31.

Division of Paediatric Dermatology, Children's Hospital AUF DER BULT, Hannover, Germany.

Neonatal and infantile erythroderma (NIE) represent the common clinical phenotype of heterogenous diseases ranging from benign and transient skin conditions to fatal multiorgan disorders. NIE regularly demands a comprehensive diagnostic workup in a multiprofessional setting, especially if newborns and young infants with the disease develop a failure to thrive and concomitant infectious, neurological or metabolic complications. By obtaining a detailed medical history and performing a thorough clinical examination, targeted diagnostic steps can be scheduled for most affected children. Read More

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http://dx.doi.org/10.1111/pai.13032DOI Listing
January 2019
5 Reads

"Molecular extracts" for allergy diagnostics and therapy.

Pediatr Allergy Immunol 2019 Feb;30(1):55-58

Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany.

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http://doi.wiley.com/10.1111/pai.13001
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http://dx.doi.org/10.1111/pai.13001DOI Listing
February 2019
4 Reads

On early metabolite exposure influencing asthma outcome, the risk of hymenoptera allergy in a birth cohort, and improvement of food allergy management at school.

Pediatr Allergy Immunol 2019 Feb;30(1):5-6

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1111/pai.13014DOI Listing
February 2019

Serum TARC level as a potential biomarker for FPIES.

Pediatr Allergy Immunol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pediatrics, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy in infants characterised by repetitive vomiting and diarrhoea occurring within one to four hours of ingesting the offending food. Diagnosis of FPIES is difficult because patients present with non-specific symptoms such as vomiting and diarrhoea, and useful diagnostic biomarkers are lacking. We report on three infants who had FPIES with a transient increase in serum thymus and activation regulated chemokine (TARC) levels one day after ingesting the offending food. Read More

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http://dx.doi.org/10.1111/pai.13030DOI Listing
January 2019
1 Read

Delayed Diagnosis of Hereditary Angioedema with C1-inhibitor Deficiency in Iranian Children and Adolescents.

Pediatr Allergy Immunol 2019 Jan 28. Epub 2019 Jan 28.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Hereditary angioedema is an autosomal dominant deficiency of C1-inhibitor (C1-INH-HAE). This rare but potentially fatal disease gives rise to episodes of bradykinin-mediated edema in face, trunk, extremities, genitalia, gastrointestinal tract and upper airway. This leads to severe outcomes including asphyxiation, unnecessary emergency abdominal surgeries, and a considerably diminished quality of life in addition to high economic burden for the health care system. Read More

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http://doi.wiley.com/10.1111/pai.13028
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http://dx.doi.org/10.1111/pai.13028DOI Listing
January 2019
2 Reads
3.397 Impact Factor

Outcome of oral immunotherapy for persistent cow's milk allergy from 11 years of experience in Finland.

Pediatr Allergy Immunol 2019 Jan 27. Epub 2019 Jan 27.

Helsinki University Hospital, Skin and Allergy Hospital, Helsinki, Finland.

Background: The safety and efficacy of long-term milk oral immunotherapy (OIT) in Finnish children with persistent cow's milk allergy (CMA) were evaluated in an open-label, non-randomized study.

Methods: During the 11-year study, 296 children aged 5 years or older with immunoglobulin E (IgE)-mediated CMA started milk OIT. Follow-up data were collected at three time points: the post-buildup phase, 1 year thereafter, and at the cross-sectional long-term follow-up between January 2016 and December 2017. Read More

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http://dx.doi.org/10.1111/pai.13025DOI Listing
January 2019
2 Reads

Detection of Local Allergic Rhinitis in children with chronic, difficult-to-treat, non-allergic rhinitis using Multiple Nasal Provocation Tests.

Pediatr Allergy Immunol 2019 Jan 27. Epub 2019 Jan 27.

Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.

Background: There is little evidence on the incidence and characteristics of local allergic rhinitis (LAR) in children. Most studies have included subjects with perennial rhinitis only and results are based on the investigation of no more than three allergens per study. Our aim was to determine the proportion of children with LAR amongst children with chronic, difficult to treat, perennial or seasonal, rhinitis but no evidence of sensitization to aeroallergens, or other alternative diagnosis. Read More

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http://dx.doi.org/10.1111/pai.13021DOI Listing
January 2019
2 Reads

Ataxia-telangiectasia: A review of clinical features and molecular pathology.

Pediatr Allergy Immunol 2019 Jan 27. Epub 2019 Jan 27.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, and the University of Medical Science, Tehran, Iran.

Ataxia telangiectasia (A-T) is an autosomal recessive primary immunodeficiency (PID) disease that is caused by mutations in ataxia telangiectasia mutated (ATM) gene encoding a serine/threonine protein kinase. A-T patients represent a broad range of clinical manifestations including progressive cerebellar ataxia, oculocutaneous telangiectasia, variable immunodeficiency, radiosensitivity, susceptibility to malignancies and increased metabolic diseases. This congenital disorder has phenotypic heterogeneity, and the severity of symptoms varies in different patients based on severity of mutations and disease progression. Read More

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http://dx.doi.org/10.1111/pai.13020DOI Listing
January 2019
1 Read
3.397 Impact Factor

Using only a subset of pneumococcal serotypes is reliable for the diagnosis of specific antibody deficiency in children: A proof-of-concept study.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1111/pai.13026DOI Listing
January 2019
2 Reads

Allergy screening in a schoolchildren-based population.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Department of Sense Organs, University Sapienza of Rome, Rome, Italy.

Background: Schoolchildren screening for allergic diseases may improve early identification and management of atopic children. The aim of this study was to perform a schoolchildren screening program for identification of children with allergic diseases.

Methods: All parents of children attending to 13 primary schools in the city of Rome were requested to fill in a demographic data form and the ChAt questionnaire. Read More

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http://dx.doi.org/10.1111/pai.13024DOI Listing
January 2019
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Differentially methylated DNA regions in early childhood wheezing: An epigenome-wide study using saliva.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.

Background: Epigenetics may play a role in wheezing and asthma development. We aimed to examine infant saliva DNA methylation in association with early childhood wheezing.

Methods: A case-control study was nested within the NINFEA birth cohort with 68 cases matched to 68 controls by sex, age (between 6 and 18 months, median: 10. Read More

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http://dx.doi.org/10.1111/pai.13023DOI Listing
January 2019
3 Reads
3.397 Impact Factor

Unsupervised trajectories of respiratory/allergic symptoms throughout childhood in the PARIS cohort.

Pediatr Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Université Paris Descartes - Sorbonne Paris Cité, EA 4064 - Epidémiologie environnementaleParis, France.

Background: Natural course and co-occurrence of asthma, eczema and allergic rhinitis through childhood are still not fully documented. We aim to identify and characterize profiles based on the time course, severity and apparent triggers of respiratory/allergy symptoms in school-aged children.

Methods: Data on occurrence, severity and triggers of asthma, rhinitis, and dermatitis symptoms were collected annually during the follow-up of the PARIS birth cohort. Read More

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http://dx.doi.org/10.1111/pai.13027DOI Listing
January 2019
2 Reads

Impact of Food Allergy on Food Insecurity and Health Literacy in a Tertiary Care Pediatric Allergy Population.

Pediatr Allergy Immunol 2019 Jan 23. Epub 2019 Jan 23.

University of Arkansas for Medical Sciences.

Background: Food insecurity (FI), limited availability of or access to nutritional foods, is linked to poor child/caregiver health. We examined FI in food allergic and non-food allergic children to determine if dietary limitations associated with food allergy increases risk of FI.

Methods: Food allergic and non-food allergic children (1-17 years) were recruited from Arkansas Children's Hospital allergy/asthma clinics. Read More

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http://dx.doi.org/10.1111/pai.13019DOI Listing
January 2019

Evaluation of the efficiency of hydrolyzed whey formula to prevent cow's milk allergy in the BALB/c mouse model.

Pediatr Allergy Immunol 2019 Jan 23. Epub 2019 Jan 23.

UMR Service de Pharmacologie et d'Immunoanalyse, CEA, INRA, Université Paris-Saclay, Laboratoire d'Immuno-Allergie Alimentaire, F-91191, Gif-sur-Yvette, France.

Background: Partially hydrolyzed milk formulas have been proposed for primary prevention in at risk infants, but evidence of their efficiency and elucidation of underlying mechanisms are still lacking. Thanks to a Th2-biased mouse model mimicking at risk patients, we aimed to assess the potency of a partially hydrolyzed whey formula (pHWF) to induce oral tolerance thus preventing further cow's milk (CM) allergy.

Methods: BALB/c mice were gavaged with pHWF, standard milk formula (SF), or vehicle only (PBS+). Read More

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http://dx.doi.org/10.1111/pai.13017DOI Listing
January 2019

Insights into tree nut and sesame consumption from a cohort of 80 peanut-allergic children.

Pediatr Allergy Immunol 2018 Dec 27. Epub 2018 Dec 27.

Section of Immunology, Allergy and Rheumatology, Department of Pediatrics, Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1111/pai.13016DOI Listing
December 2018

Anaphylaxis admissions in pediatric intensive care units: follow up and risk of recurrence.

Pediatr Allergy Immunol 2018 Dec 27. Epub 2018 Dec 27.

CHU Lille, Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, F-59000, Lille, France.

Background: Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow-up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis.

Methods: We conducted a telephone survey of 166 children (≤18y) hospitalized from 2003 to 2013. Read More

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http://dx.doi.org/10.1111/pai.13015DOI Listing
December 2018
1 Read

Peanut oral immunotherapy increases IgG4 to Ara h 1, 2, and 6 but does not affect IgG4 to other allergens.

Pediatr Allergy Immunol 2019 Mar 31;30(2):248-252. Epub 2019 Jan 31.

Department of Allergology, the Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/pai.13012DOI Listing
March 2019
2 Reads

Association of maternal allergy with human milk soluble CD14 and fatty acids, and early childhood atopic dermatitis.

Pediatr Allergy Immunol 2019 Mar 11;30(2):204-213. Epub 2019 Feb 11.

Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background: This study aimed to investigate whether maternal allergy is associated with soluble CD14 (sCD14) and fatty acid composition in different stages of lactation and the onset of atopic dermatitis (AD) in early childhood.

Methods: In total, 443 mother-child groups (445 children) were enrolled in the Prediction of Allergies in Taiwanese Children birth cohort study. Colostrum and mature milk at 2 months postpartum (2-month HM) were collected from lactating mothers. Read More

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http://dx.doi.org/10.1111/pai.13011DOI Listing
March 2019
3.397 Impact Factor

The efficacy and safety of fluticasone/salmeterol compared to fluticasone in children younger than four years of age.

Pediatr Allergy Immunol 2019 Mar 6;30(2):195-203. Epub 2019 Feb 6.

Clinical Operations Department, GlaxoSmithKline K.K., Tokyo, Japan.

Background: Fluticasone propionate 50 μg/salmeterol xinafoate 25 μg (FP/SAL) is widely used in adults and children with asthma, but there is sparse information on its use in very young children.

Methods: This was a randomized, double-blind, multicentre, controlled trial conducted in children aged 8 months to 4 years. During a 2-week run-in period, they all received FP twice daily. Read More

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http://dx.doi.org/10.1111/pai.13010DOI Listing
March 2019
9 Reads

Editorial comments on this issue of the Journal.

Pediatr Allergy Immunol 2018 12;29(8):787-788

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1111/pai.13003DOI Listing
December 2018
1 Read

Relative reactivity to egg white and yolk or change upon heating as markers for baked egg tolerance.

Pediatr Allergy Immunol 2019 Mar 27;30(2):225-233. Epub 2019 Jan 27.

INRA, UR 1268 Biopolymères, Interactions, Assemblages, Nantes, France.

Background: Hen's egg food allergy is frequent in childhood and phenotypically heterogeneous. Some children can tolerate extensively heated egg. We investigated whether individual relative responses could differentiate children who tolerate baked egg. Read More

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http://dx.doi.org/10.1111/pai.13009DOI Listing
March 2019
2 Reads

New perspectives of childhood asthma treatment with biologics.

Pediatr Allergy Immunol 2019 Mar 16;30(2):159-171. Epub 2018 Dec 16.

Department of Allergology-Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.

Asthma is no longer considered as a single disease but rather as a syndrome corresponding to different entities and pathophysiologic pathways. A targeted strategy is part of personalized medicine which aims to better define each patient's phenotype and endotype so as to prescribe the most suitable treatment at an individual level. Omalizumab and, more recently, mepolizumab are the first biologics approved for children (6-18 years). Read More

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http://doi.wiley.com/10.1111/pai.13007
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http://dx.doi.org/10.1111/pai.13007DOI Listing
March 2019
10 Reads

Enhancement of immune response mediated by oropharyngeal colostrum administration in preterm neonates.

Pediatr Allergy Immunol 2019 Mar 13;30(2):234-241. Epub 2018 Dec 13.

Unit of Neonatology, Pediatric Service, Hospital Universitario Materno-Infantil Virgen de las Nieves, Granada, Spain.

Background: The immune system of preterm infants is immature, being a significant cause of morbidity and mortality, particularly in the preterm infant. Oropharyngeal colostrum administration could be an immunomodulatory aid. Our aim was to evaluate the effect of oropharyngeal colostrum on the serum levels of immunoglobulins, lactoferrin, and resistin during the first month of life and to track the clinical outcome of the neonates. Read More

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http://doi.wiley.com/10.1111/pai.13008
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http://dx.doi.org/10.1111/pai.13008DOI Listing
March 2019
8 Reads

Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years.

Pediatr Allergy Immunol 2018 12 14;29(8):808-814. Epub 2018 Nov 14.

Wellington Asthma Research Group, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand.

Background: In a two-centre randomized placebo-controlled trial of Lactobacillus rhamnosus HN001 (HN001) (6 × 10 colony-forming units [cfu]) or Bifidobacterium lactis HN019 (HN019) (9 × 10 cfu) taken daily from 35-week gestation to 6 months' post-partum in mothers while breastfeeding and from birth to age 2 years in infants, we showed that HN001 significantly protected against eczema development at 2, 4 and 6 years and atopic sensitization at 6 years. There was no effect of HN019. We report here the findings for 11 year outcomes. Read More

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http://doi.wiley.com/10.1111/pai.12982
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http://dx.doi.org/10.1111/pai.12982DOI Listing
December 2018
4 Reads

Feasibility of the Allergy Questionnaire for Athletes (AQUA ) in pediatric age.

Pediatr Allergy Immunol 2019 Mar 13;30(2):242-245. Epub 2018 Dec 13.

Institute of Biomedicine and Molecular Immunology, National Research Council of Italy, Palermo, Italy.

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http://doi.wiley.com/10.1111/pai.13006
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http://dx.doi.org/10.1111/pai.13006DOI Listing
March 2019
12 Reads

Spectrum of susceptibility to air quality and weather in individual children with atopic dermatitis.

Pediatr Allergy Immunol 2019 Mar 27;30(2):179-187. Epub 2018 Dec 27.

Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do, Korea.

Background: Exposure to air pollution aggravates symptoms of atopic dermatitis (AD) in children in the population studies. Variability in individual patient's response from individual susceptibility is needed to be explored.

Objective: This study aimed to investigate spectrum of individual variability in the associations between AD symptoms and air quality. Read More

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http://doi.wiley.com/10.1111/pai.13005
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http://dx.doi.org/10.1111/pai.13005DOI Listing
March 2019
15 Reads

Editorial comments on this issue of the Journal.

Pediatr Allergy Immunol 2018 11;29(7):677-678

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1111/pai.12985DOI Listing
November 2018
1 Read

Hygienic conditions influence sensitization to Blomia tropicalis allergenic components: Results from the FRAAT birth cohort.

Pediatr Allergy Immunol 2019 Mar 4;30(2):172-178. Epub 2018 Dec 4.

Institute for Immunological Research, University of Cartagena, Cartagena, Colombia.

Background: In tropical zones, perennial exposure to house dust mite (HDM) allergens and helminth infections is present. Studying the impact of these conditions on the inception and evolution of allergic diseases is necessary to have an accurate view of their natural history. We aimed to evaluate the dynamics of genuine sensitization to Blomia tropicalis and Ascaris in children from the FRAAT birth cohort and the effects of helminth infection, environmental HDM allergen levels, and sociodemographic factors. Read More

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http://dx.doi.org/10.1111/pai.13004DOI Listing
March 2019
13 Reads

Egg OIT in clinical practice (SEICAP II): Maintenance patterns and desensitization state after normalizing the diet.

Pediatr Allergy Immunol 2019 Mar 18;30(2):214-224. Epub 2018 Dec 18.

Pediatric Allergy Section, Severo Ochoa Hospital, Madrid, Spain.

Background: It is unknown which are the most suitable maintenance pattern and egg consumption to maintain the desensitization state after ending the oral immunotherapy (OIT). This multicenter, randomized, controlled trial compared two OIT maintenance patterns with pasteurized egg white (PEW), evaluating the egg consumption effect on the desensitization state after ending the OIT.

Methods: One hundred and one children with confirmed egg allergy were randomized: 25 to an egg-free diet (CG) and 76 to an OIT year with PEW and two maintenance patterns, 38 patients to daily 3. Read More

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http://doi.wiley.com/10.1111/pai.13002
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http://dx.doi.org/10.1111/pai.13002DOI Listing
March 2019
19 Reads

Non-IgE-mediated gastrointestinal allergies-Do they have a place in a new model of the Allergic March.

Pediatr Allergy Immunol 2019 Mar 10;30(2):149-158. Epub 2019 Jan 10.

Department Gastroenterology, Great Ormond Street Hospital, London, UK.

The rise in food allergy has been described as the "second wave" of the allergy epidemic, with some developed countries reporting a prevalence of 10% of challenge-proven food allergies. Recognition of the Allergic March has played a crucial role in identifying causality in allergic conditions, linking atopic dermatitis to food allergy and food allergy to other atopic disorders, thereby highlighting opportunities in prevention and the importance of early intervention. This publication will establish the value of weaving the less well-understood, non-IgE-mediated food allergy into the Allergic March and mapping its progression through childhood and its associated co-morbidities. Read More

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http://dx.doi.org/10.1111/pai.13000DOI Listing
March 2019
2 Reads
3.397 Impact Factor

Changes in the relationship between childhood asthma and ambient air pollution in Taiwan: Results from a nationwide survey repeated 5 years apart.

Pediatr Allergy Immunol 2019 Mar 14;30(2):188-194. Epub 2018 Nov 14.

National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.

Background: Childhood asthma is a common disease whose prevalence is changing. Shift in environmental exposure was one of the plausible explanations. This study investigated changes in the association between childhood asthma and ambient air pollution occurring over time. Read More

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http://dx.doi.org/10.1111/pai.12999DOI Listing
March 2019
4 Reads

Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood.

Pediatr Allergy Immunol 2019 Feb 9;30(1):107-116. Epub 2019 Jan 9.

UMR Service de Pharmacologie et Immunoanalyse, Laboratoire d'Immuno-Allergie Alimentaire, CEA, INRA, Université Paris-Saclay, Gif-sur-Yvette, France.

Background: Breastmilk (BM) may participate in driving gut barrier function and immunity in the neonate. We analyzed immune and growth factor concentrations in early BM and their association with maternal/environmental characteristics and with food allergy (FA) in childhood.

Methods: One BM sample was collected in maternity from some mothers in the EDEN birth cohort (n = 2002 mother-child dyads). Read More

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http://dx.doi.org/10.1111/pai.12998DOI Listing
February 2019
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Structured intervention plan including component-resolved diagnostics helps reducing the burden of food allergy among school-aged children.

Pediatr Allergy Immunol 2019 Feb 13;30(1):99-106. Epub 2018 Dec 13.

Härkätie Primary Care Center, Lieto, Finland.

Background: Food allergies can substantially burden patients and families by negatively affecting finances, social relationships, and personal perceptions of health. This study was performed under the Finnish Allergy Programme aimed at reducing avoidance diets to foods in schoolchildren by 50%. The main goal of this study was to investigate how many children could be freed from diet restrictions in a Finnish school district through a diagnostic algorithm including component-resolved diagnostics and food challenge. Read More

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http://doi.wiley.com/10.1111/pai.12996
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http://dx.doi.org/10.1111/pai.12996DOI Listing
February 2019
3 Reads

Apovitellin identified as a novel major egg allergen in goose egg allergy.

Pediatr Allergy Immunol 2019 Mar 14;30(2):246-248. Epub 2018 Nov 14.

Paediatric Allergy and Immunology Unit, Department of Paediatric, A. Meyer Children's Hospital, University of Florence, Florence, Italy.

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http://doi.wiley.com/10.1111/pai.12997
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http://dx.doi.org/10.1111/pai.12997DOI Listing
March 2019
7 Reads

Impact of IgE sensitization and rhinitis on inflammatory biomarkers and lung function in adolescents with and without asthma.

Pediatr Allergy Immunol 2019 Feb 14;30(1):74-80. Epub 2018 Nov 14.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Both allergic and non-allergic rhinitis are associated with worse asthma control. However, it is unclear how IgE sensitization and/or rhinitis are associated with lung function. We therefore evaluated the effect of rhinitis and sensitization on lung function, including the periphery of the airway system, and inflammatory biomarkers in individuals with and without asthma. Read More

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http://doi.wiley.com/10.1111/pai.12994
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http://dx.doi.org/10.1111/pai.12994DOI Listing
February 2019
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Prenatal high molecular weight phthalates and bisphenol A, and childhood respiratory and allergic outcomes.

Pediatr Allergy Immunol 2019 Feb 22;30(1):36-46. Epub 2018 Nov 22.

Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California.

Background: The prevalence of asthma and allergy is increasing in US children. In utero exposure to chemicals used in personal care products and plastics may contribute to increase in these diseases.

Methods: We quantified urinary concentrations of eight phthalate metabolites and bisphenol A in mothers twice during pregnancy in 1999-2000 in Salinas, California. Read More

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http://doi.wiley.com/10.1111/pai.12992
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February 2019
12 Reads