726,936 results match your criteria Pediatric Allergy Immunology and Pulmonology[Journal]


Impact of diagnosis and therapy on cognitive function in urea cycle disorders.

Ann Neurol 2019 Apr 24. Epub 2019 Apr 24.

Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

Objective: Individuals with urea cycle disorders (UCDs) often present with intellectual and developmental disabilities. The major aim of this study was to evaluate the impact of diagnostic and therapeutic interventions on cognitive outcomes in UCDs.

Methods: This prospective, observational, multicenter study includes data from 503 individuals with UCDs who had comprehensive neurocognitive testing with a cumulative follow-up of 702 patient-years. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25492
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http://dx.doi.org/10.1002/ana.25492DOI Listing
April 2019
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Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.

In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. Read More

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http://dx.doi.org/10.1002/ijc.32361DOI Listing

Using Artificial Intelligence to Identify Factors Associated with Autism Spectrum Disorder in Adolescents with Cerebral Palsy.

Neuropediatrics 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatric Orthopaedic Surgery, Lenval University Pediatric Hospital of Nice, Nice, France.

Autism spectrum disorder (ASD) is common in adolescents with cerebral palsy (CP) and there is a lack of studies applying artificial intelligence to investigate this field and this population in particular. The aim of this study is to develop and test a predictive learning model to identify factors associated with ASD in adolescents with CP. This was a multicenter controlled cohort study of 102 adolescents with CP (61 males, 41 females; mean age ± SD [standard deviation] = 16. Read More

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http://dx.doi.org/10.1055/s-0039-1685525DOI Listing

In Situ Modification of Tissue Stem and Progenitor Cell Genomes.

Cell Rep 2019 Apr;27(4):1254-1264.e7

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA; Joslin Diabetes Center, Boston, MA 02215, USA. Electronic address:

In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis and regeneration, is of particular interest. Here, we use a sensitive Cre/lox fluorescent reporter system to test the efficiency of genome modification following in vivo transduction by adeno-associated viruses (AAVs) in tissue stem and progenitor cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.105DOI Listing

Direct Lung Sampling Indicates That Established Pathogens Dominate Early Infections in Children with Cystic Fibrosis.

Cell Rep 2019 Apr;27(4):1190-1204.e3

Department of Microbiology and Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address:

Culture and sequencing have produced divergent hypotheses about cystic fibrosis (CF) lung infections. Culturing suggests that CF lungs are uninfected before colonization by a limited group of CF pathogens. Sequencing suggests diverse communities of mostly oral bacteria inhabit lungs early on and diversity decreases as disease progresses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193042
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http://dx.doi.org/10.1016/j.celrep.2019.03.086DOI Listing
April 2019
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Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway.

Chem Biol Interact 2019 Apr 21. Epub 2019 Apr 21.

Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, PR China.

Objective: The aim of this study is to investigate the role of mircoRNA-200c-3p (miR-200c-3p) on hippocampal neuron injury in epileptic rats through the regulation of the AKT signaling pathway by targeting RECK.

Methods: The epilepsy rat model was induced by intraperitoneal injection of lithium chloride-pilocarpine. Successful modeled rats were injected with miR-200c-3p inhibitors, inhibitors NC, siRNA-negative control (NC) and RECK-siRNA. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.027DOI Listing

Hazardous Chemical Emergencies and Poisonings.

N Engl J Med 2019 04;380(17):1638-1655

From the Division of Emergency Medicine and Poison Control Center, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (F.M.H.); the Department of Homeland Security, Washington, DC (M.A.K.); and the Division of Medical Toxicology, Department of Emergency Medicine, University of Connecticut Health Center and Hartford Hospital, Hartford (C.A.M.).

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http://dx.doi.org/10.1056/NEJMra1504690DOI Listing

Bilateral Papillitis and Anterior Uveitis in a Pediatric Patient.

S D Med 2019 Mar;72(3):110-113

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

We report a case of bilateral papillitis and anterior uveitis in a pediatric patient with preceding viral prodrome. Because this is a rare disease in the pediatric population, work-up in this case was extensive given the wide differential of papilledema in the pediatric setting. The clinical significance of this case is to bring to light the timely recognition, follow-up, and treatment of this disease to minimize the burden to the patient and family. Read More

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Heterozygosity mapping for human dominant trait variants.

Hum Mutat 2019 Apr 24. Epub 2019 Apr 24.

Laboratory of Statistical Genetics, Rockefeller University, New York, New York.

Homozygosity mapping is a well-known technique to identify runs of homozygous variants that are likely to harbor genes responsible for autosomal recessive disease, but a comparable method for autosomal dominant traits has been lacking. We developed an approach to map dominant disease genes based on heterozygosity frequencies of sequence variants in the immediate vicinity of a dominant trait. We demonstrate through theoretical analysis that DNA variants surrounding an inherited dominant disease variant tend to have increased heterozygosity compared with variants elsewhere in the genome. Read More

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http://dx.doi.org/10.1002/humu.23765DOI Listing

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.

PLoS Pathog 2019 Apr 24;15(4):e1007709. Epub 2019 Apr 24.

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed that protective STAT1 signaling controls viral replication and pathogenesis, but the immune mechanisms that noroviruses exploit to induce pathology are elusive. Here, we show that gastrointestinal MNV infection leads to widespread IL-1β maturation in MNV-susceptible STAT1-deficient mice. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007709DOI Listing

Prevalence, attitudes, behaviours and policy evaluation of midwakh smoking among young people in the United Arab Emirates: Cross-sectional analysis of the Global Youth Tobacco Survey.

PLoS One 2019 24;14(4):e0215899. Epub 2019 Apr 24.

Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.

Introduction: Non-cigarette tobacco products are an increasing public health concern globally. Little is known about midwakh, a pipe indigenous to the United Arab Emirates (UAE). This study aimed to assess the prevalence, attitudes, behaviours and policy evaluation of midwakh smoking among 13 to 15 year olds in the UAE. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215899PLOS

Use of PTC124 for nonsense suppression therapy targeting BMP4 nonsense variants in vitro and the bmp4st72 allele in zebrafish.

PLoS One 2019 24;14(4):e0212121. Epub 2019 Apr 24.

Division of Genetics, Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States of America.

Nonsense suppression therapy (NST) utilizes compounds such as PTC124 (Ataluren) to induce translational read-through of stop variants by promoting the insertion of near cognate, aminoacyl tRNAs that yield functional proteins. We used NST with PTC124 to determine if we could successfully rescue nonsense variants in human Bone Morphogenetic Protein 4 (BMP4) in vitro and in a zebrafish bmp4 allele with a stop variant in vivo. We transfected 293T/17 cells with wildtype or mutant human BMP4 cDNA containing p. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212121PLOS

A predictive computational model reveals that GIV/Girdin serves as a tunable valve for EGFR-stimulated Cyclic AMP Signals.

Mol Biol Cell 2019 Apr 24:mbcE18100630. Epub 2019 Apr 24.

Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla CA 92093.

Cellular levels of the versatile second messenger, cyclic-(c)AMP are regulated by the antagonistic actions of the canonical G protein → adenylyl cyclase pathway that is initiated by G-protein-coupled receptors (GPCRs) and attenuated by phosphodiesterases (PDEs). Dysregulated cAMP signaling drives many diseases, , its low levels facilitate numerous sinister properties of cancer cells. Recently, an alternative paradigm for cAMP signaling has emerged in which growth factor-receptor tyrosine kinases (RTKs; , EGFR) access and modulate G proteins via a cytosolic guanine-nucleotide exchange modulator (GEM), GIV/Girdin; dysregulation of this pathway is frequently encountered in cancers. Read More

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http://dx.doi.org/10.1091/mbc.E18-10-0630DOI Listing

Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure.

J Hum Lact 2019 Apr 24:890334419843307. Epub 2019 Apr 24.

2 Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Background: Cyclobenzaprine is a skeletal muscle relaxant primarily used in the treatment of pain. Its use during lactation is a matter of concern as its level of exposure to infants through human milk is still unknown.

Research Aim: The aim of this study was to determine cyclobenzaprine concentrations in the milk samples collected from two lactating mothers. Read More

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http://dx.doi.org/10.1177/0890334419843307DOI Listing

HLA-B*54:01 Is Associated With Susceptibility to Kawasaki Disease.

Circ Genom Precis Med 2019 Jan;12(1):e002365

Asan Institute for Life Sciences (Y.-C.K., B.K.S., J.-K.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1161/CIRCGEN.118.002365DOI Listing
January 2019

Protective impacts of long noncoding RNA taurine-upregulated 1 against lipopolysaccharide-evoked injury in MRC-5 cells through inhibition of microRNA-127.

J Cell Biochem 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatrics, Jining No.1 People's Hospital, Jining, China.

Background: Pneumonia is a respiratory disease, which is triggered by pathogenic microorganisms or physical/chemical factors. Increasing evidence confirmed the vital impacts of long noncoding RNAs on various inflammatory diseases. Nonetheless, the influence of taurine-upregulated 1 (TUG1) in pneumonia remains vague. Read More

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http://dx.doi.org/10.1002/jcb.28755DOI Listing

Silencing fibroblast growth factor 7 inhibits krypton laser-induced choroidal neovascularization in a rat model.

J Cell Biochem 2019 Apr 24. Epub 2019 Apr 24.

Department of Orbital Disease and Ocular Plastic Surgery, The Second Hospital of Jilin University, Changchun, China.

Choroidal neovascularization (CNV), a characteristic of age-related macular degeneration, is an underlying cause of severe vision loss among elderly patients. Fibroblast growth factor (FGF) is suggested to exert an important role in the pathogenesis of CNV. However, the molecular mechanisms governing this event are not fully elucidated. Read More

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http://dx.doi.org/10.1002/jcb.28652DOI Listing

MicroRNA-1225 activates Keap1-Nrf2-HO-1 signalling to inhibit TNFα-induced osteoclastogenesis by mediating ROS generation.

Cell Biochem Funct 2019 Apr 24. Epub 2019 Apr 24.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

The influence of miRNA-1225-5p (miR-1225) and Keap1-Nrf2 signalling on in vitro osteoclast differentiation in mouse models was studied along with the underlying mechanism. In differentiated bone marrow-derived macrophages (BMMs), downregulated miR-1225 and upregulated Keap1 were observed in the course of receptor activator of nuclear factor kappa-Β ligand (RANKL)-mediated osteoclastogenesis. Bioinformatic analysis and dual-luciferase reporter assay showed that miR-1225 targeted the three prime untranslated region (3'-UTR) of Keap1 mRNA and caused its degradation. Read More

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http://dx.doi.org/10.1002/cbf.3394DOI Listing

Viruses associated with acute respiratory infection in a community-based cohort of healthy NZ children.

J Med Virol 2019 Apr 24. Epub 2019 Apr 24.

Virology Research Laboratory, Prince of Wales Hospital, Sydney, NSW, Australia.

Acute respiratory infections (ARIs) are a major cause of morbidity among children. Respiratory viruses are commonly detected in both symptomatic and asymptomatic periods. The rates of infection, and community epidemiology of respiratory viruses in healthy children needs further definition to assist interpretation of molecular diagnostic assays in this population. Read More

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http://dx.doi.org/10.1002/jmv.25493DOI Listing

Sustained Long-Term Efficacy and Safety of Adalimumab in Pediatric Patients with Severe Chronic Plaque Psoriasis from a Randomised, Double-Blind, Phase 3 Study.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Venerology and Allergy, Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Adalimumab (Humira , AbbVie Inc, USA) is EMA approved for children ages ≥4 years with severe plaque-psoriasis.

Objectives: Evaluate long-term efficacy and safety of adalimumab in children with severe plaque psoriasis.

Methods: Results are from the 52-week long-term extension (LTE) of the randomized, double-blind, double-dummy, phase-3 trial, in children with severe plaque psoriasis (results from prior periods are published). Read More

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http://dx.doi.org/10.1111/bjd.18029DOI Listing

Association of PDGFRB Mutations With Pediatric Myofibroma and Myofibromatosis.

JAMA Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

Importance: Myofibroma is the most frequent fibrous tumor in children. Multicentric myofibroma (referred to as infantile myofibromatosis) is a life-threatening disease.

Objective: To determine the frequency, spectrum, and clinical implications of mutations in the PDGFRB receptor tyrosine kinase found in sporadic myofibroma and myofibromatosis. Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.0114DOI Listing

Capillary Malformation-Arteriovenous Malformation Syndrome.

JAMA Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Division of Dermatology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1001/jamadermatol.2019.0319DOI Listing

We Can Learn From the Past, but We Must Pave the Future of Congenital Heart Disease Research-Reply.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1001/jamacardio.2019.1076DOI Listing

Detecting Developmental Delay and Autism Through Machine Learning Models Using Home Videos of Bangladeshi Children: Development and Validation Study.

J Med Internet Res 2019 Apr 24;21(4):e13822. Epub 2019 Apr 24.

Division of Systems Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, United States.

Background: Autism spectrum disorder (ASD) is currently diagnosed using qualitative methods that measure between 20-100 behaviors, can span multiple appointments with trained clinicians, and take several hours to complete. In our previous work, we demonstrated the efficacy of machine learning classifiers to accelerate the process by collecting home videos of US-based children, identifying a reduced subset of behavioral features that are scored by untrained raters using a machine learning classifier to determine children's "risk scores" for autism. We achieved an accuracy of 92% (95% CI 88%-97%) on US videos using a classifier built on five features. Read More

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http://dx.doi.org/10.2196/13822DOI Listing

Combining Hypnosis and Biofeedback in Primary Care Pediatrics.

Authors:
Linda Thomson

Am J Clin Hypn 2019 Apr;61(4):335-344

a Springfield Medical Care Systems , Springfield , Vermont , USA.

The incidence of stress-related, psychophysiological disorders in children is increasing. A goal of both parenting and pediatric health care is to teach children the skills of problem solving, affective and physical regulation, and techniques to better manage stress. In primary care pediatrics, both hypnotherapy and biofeedback can be used to teach psychophysiological self-regulation through relaxation and stress management affecting cognitive change and improving the child's self-image. Read More

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http://dx.doi.org/10.1080/00029157.2018.1511409DOI Listing

Gastric Peroral Endoscopic Myotomy for Treatment of Congenital Pyloric Stenosis-First Clinical Experience.

J Laparoendosc Adv Surg Tech A 2019 Apr 23. Epub 2019 Apr 23.

5 Department of Endoscopy, The First Saint-Petersburg State Medical University Named of Acad. I.P. Pavlov, Saint Petersburg, Russia.

Traditionally, a laparoscopic approach is used for treatment of congenital hypertrophic pyloric stenosis (CHPS) in newborns and infants. The novel technique-Gastric Per Oral Endoscopic Myotomy (G-POEM) had been proposed as an alternative method. G-POEM is a procedure that is recently being used for treatment of gastroparesis in adults. Read More

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http://dx.doi.org/10.1089/lap.2018.0803DOI Listing

Comparing modalities of conducting the six-minute walk test in healthy children and adolescents.

Minerva Pediatr 2019 Jun;71(3):229-234

Division of Cardiology, Pulmology, Allergology, and Cystic Fibrosis, Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria.

Background: The 6-minute walk test (6MWT) in children can be performed in the conventional way, or by using a measuring wheel. This study aimed to compare these test modalities and to determine influencing factors.

Methods: The study included 317 healthy children (172 boys) between 6 and 15 years from elementary schools and high schools, who were randomly assigned to perform a 6MWT either with or without a measuring wheel according to the guidelines of the American Thoracic Society. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05185-XDOI Listing

Why do we give "orphan" approval to biologic therapies but not to extracorporeal blood purification therapies for hyperinflammatory syndromes?

Minerva Anestesiol 2019 May;85(5):465-467

Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA -

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http://dx.doi.org/10.23736/S0375-9393.19.13711-XDOI Listing

Trajectories of hemoglobin A1c and BMI z-score over four decades among 2-18 year olds with type 1 diabetes.

Pediatr Diabetes 2019 Apr 24. Epub 2019 Apr 24.

University of Colorado School of Medicine, Departments of Pediatrics and Epidemiology, Denver CO, US.

Objectives: To determine trajectories of glycemic control and BMI z-score in a large pediatric sample with type 1 diabetes (T1D) over a 38-year period, and to evaluate sex differences and temporal changes in the prevalence of these trajectories.

Methods: We conducted a longitudinal, retrospective study of 7002 2-18 year olds with T1D followed between 1978 and 2016 at a single center. Group-based modeling was used to identify trajectories for hemoglobin A1c (HbA1c) and BMI z-score. Read More

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http://dx.doi.org/10.1111/pedi.12862DOI Listing

A qualitative investigation of policy for youth with problematic sexual behavior.

J Community Psychol 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatrics, Center on Child Abuse and Neglect, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

Aims: Community management of youth with problematic sexual behavior (PSB) is complex. Public policies and service practices have historically utilized adult-focused approaches with limited research outcomes. This descriptive case study aimed to address this gap by documenting current PSB policies and policy reforms for community-based management systems. Read More

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http://dx.doi.org/10.1002/jcop.22187DOI Listing

Hydrogen sulfide abrogates heart valve calcification: Implications for calcific aortic valve disease.

Br J Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.

Background And Purpose: Calcification of heart valves is a frequent pathological finding in CKD patients and in elderly. Hydrogen sulfide (H S) has been suggested to possess various anti-calcific actions. We aimed to investigate H S as a potential therapeutic in valvular calcification and to identify its targets in the pathogenesis. Read More

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http://dx.doi.org/10.1111/bph.14691DOI Listing

Nursing interventions in palliative care in Pediatric Oncology: an integrative review.

Rev Bras Enferm 2019 Mar-Apr;72(2):531-540. Epub 2019 Apr 18.

Universidade Federal Fluminense, Faculdade de Enfermagem. Niterói-RJ, Brasil.

Objective: to identify, in scientific productions, nursing interventions in palliative care in children and adolescents with cancer.

Method: integrative review of the literature through the databases: CINAHL, MEDLINE, IBECS, LILACS and SCIELO, carried out in October and November 2017.

Results: we analyzed 18 articles that met the inclusion criteria. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0121DOI Listing

The meaning of a "good nurse" in pediatric care: a concept analysis.

Rev Bras Enferm 2019 Mar-Apr;72(2):494-504. Epub 2019 Apr 18.

Universidade de São Paulo. São Paulo-SP, Brasil.

Objective: to analyze the attributes, antecedents and consequences of the concept a "good nurse" in the context of Pediatrics.

Method: concept analysis study based on Rodgers' evolutionary method. Theoretical stage consisted of searching for articles in the CINAHL, Embase and Pubmed databases and a practical stage of semi-structured interviews with pediatric nurses. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0497DOI Listing

The social network of adolescents who need special health care.

Rev Bras Enferm 2019 Mar-Apr;72(2):442-449. Epub 2019 Apr 18.

Universidade Federal de Santa Maria. Santa Maria-RS, Brasil.

Objective: To describe the social network of adolescents who need special health care.

Method: A qualitative, descriptive and exploratory study conducted between 2016 and 2017 in the pediatric outpatient clinic of a teaching hospital in southern Brazil. Thirty-five semi-structured interviews were conducted with adolescents between 12 and 18 years of age, followed by the construction of genograms and ecomaps. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0543DOI Listing

Family members' satisfaction with the care flow in the Pediatric Emergency Department.

Rev Bras Enferm 2019 Mar-Apr;72(2):435-441. Epub 2019 Apr 18.

Universidade Federal de São Paulo, Escola Paulista de Enfermagem. São Paulo-SP, Brasil.

Objective: To evaluate the satisfaction index of the pediatric patient's caregiver (person responsible for the child) regarding the waiting time for the care flow in an emergency service.

Method: A prospective, cross-sectional, quantitative study with 300 family members in the Pediatric Emergency Department of a general hospital. An instrument was used to analyze the service flow, waiting time and satisfaction evaluation. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0388DOI Listing
April 2019
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Analysis of the efficiency of an emergency network for the treatment of multiple burn victims.

Rev Col Bras Cir 2019 18;46(2):e2115. Epub 2019 Apr 18.

Harvard Medical School, Program in Global Surgery and Social Change, Boston, Massachusetts, Estados Unidos da América.

Objective: to evaluate the effectiveness of the adopted strategy and the care quality for pediatric trauma in the survival of patients attended after a disaster in a city in the interior of Minas Gerais state, compared to the expected results of studies on infant mortality in major burns.

Methods: retrospective observational analysis of ten patients who were burned and transferred to a trauma reference center. We used the modified R-Baux score to estimate the expected mortality. Read More

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http://dx.doi.org/10.1590/0100-6991e-20192115DOI Listing

Accidents in childhood: casuistry of a tertiary service in a medium-sized city in Brazil.

Rev Col Bras Cir 2019 18;46(2):e2104. Epub 2019 Apr 18.

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Departamento de Cirurgia e Ortopedia, Botucatu, SP, Brasil.

Objective: to investigate the main causes and most common risk situations related to childhood accidents, in our local reality.

Methods: an observational, cross-sectional, retrospective, descriptive, and analytical study from the medical records of patients attended in the pediatric emergency services of the hospital complex of Hospital das Clínicas, Botucatu Medical School - UNESP, in 2016. We included patients from zero to 15 years old who had received medical care related to accidents, determining age, gender, type of accident, period of the day, accident place, and history of previous accidents. Read More

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http://dx.doi.org/10.1590/0100-6991e-20192104DOI Listing

UNC13D Deficiency Associated With Epileptic Seizures and Antibody Deficiency: The First Case from the Iranian National Registry.

J Investig Allergol Clin Immunol 2019 Apr;29(2):160-162

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran, and the University of Medical Science, Tehran, Iran.

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http://dx.doi.org/10.18176/jiaci.0362DOI Listing

Two Neonatal Cases of Food Protein-Induced Enterocolitis Syndrome With Pale Stool and Transient Biliary Dilatation.

J Investig Allergol Clin Immunol 2019 Apr;29(2):158-159

Department of Pediatrics, Saitama Medical Center Jichi Medical University, Saitama, Japan.

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http://dx.doi.org/10.18176/jiaci.0360DOI Listing

Isotretinoin in Severe Peanut- and Soy-Allergic Patients: Is it Safe or Not?

J Investig Allergol Clin Immunol 2019 Apr;29(2):146-148

KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium.

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http://dx.doi.org/10.18176/jiaci.0352DOI Listing

Omalizumab in An 8-Year-Old Boy With Diabetes Mellitus and Refractory Chronic Spontaneous Urticaria.

J Investig Allergol Clin Immunol 2019 Apr;29(2):144-146

Department of Pediatrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital, Martin, Slovakia.

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http://dx.doi.org/10.18176/jiaci.0351DOI Listing

Loquat (Eriobotrya japonica) allergy, including anaphylaxis, is induced by a Bet v1 homolog.

J Investig Allergol Clin Immunol 2019 Apr 24. Epub 2019 Apr 24.

Faculty of Education, Shitennoji University, Habikino, Japan.

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http://dx.doi.org/10.18176/jiaci.0406DOI Listing

Beyond Blood Smears-Qualification of the 18S rRNA as a Biomarker for Controlled Human Malaria Infections.

Am J Trop Med Hyg 2019 Apr 22. Epub 2019 Apr 22.

Department of Microbiology, University of Washington, Seattle, Washington.

18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and 18S rRNA/rDNA biomarker nucleic acid tests (NATs) for time to positivity. We validated a multiplex quantitative reverse transcription-PCR (qRT-PCR) for 18S rRNA, prospectively compared blood smears and qRT-PCR for three trials, and modeled treatment effects at different biomarker-defined parasite densities to assess the impact on infection detection, symptom reduction, and measured intervention efficacy. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0094DOI Listing

Pediatric discharge against medical advice.

Int J Health Care Qual Assur 2019 Mar;32(2):366-374

Department of Public Health Administration, Ministry of Health Saudi Arabia, Saudi Board in Community Medicine, Jeddah, Saudi Arabia.

Purpose: The purpose of this paper is to identify the reasons for discharges against medical advice (DAMA) and the possible outcomes among pediatric patients.

Design/methodology/approach: A retrospective cohort study was conducted on all children admitted and then discharged against medical advice in two maternity and children's hospitals in Jeddah, 2014. Phone interviews were conducted, and medical records were reviewed for DAMA and control groups; a semi-structured questionnaire was used to collect this information. Read More

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http://dx.doi.org/10.1108/IJHCQA-02-2018-0032DOI Listing

Detection of recurrent brain tumors in children: No significant difference in sensitivity between unenhanced and contrast-enhanced MRI.

Neuroradiol J 2019 Apr 24:1971400919845619. Epub 2019 Apr 24.

1 Pediatric Radiology Department, Clocheville Hospital, University Hospital Center of Tours, France.

Background: Magnetic resonance imaging (MRI) with a gadolinium injection is currently used in the follow-up of children in remission of cerebral tumors (CTs). Intracerebral gadolinium deposition has been recently reported with unknown risks. The aim of this study was to evaluate the sensitivity of unenhanced brain MRI (U-MRI) in detection of tumor recurrence. Read More

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http://dx.doi.org/10.1177/1971400919845619DOI Listing

Modern pediatric formulations of the soft candies in the form of a jelly: determination of metoclopramide content and dissolution.

Pharm Dev Technol 2019 Apr 24:1-22. Epub 2019 Apr 24.

a Laboratory of Pharmaceutical Analysis, Department of Pharmaceutical Technology , School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki , 54124 Thessaloniki , Greece.

In paediatrics, it is crucial to ameliorate the unpleasant taste of oral pharmaceutical formulations in order to facilitate patient compliance. Scientists' attempt to develop modern products for children is included among the new trends in pharmaceutical technology. Designing the preparation procedures and selecting the age-appropriate dosage form should be based on a benefit-risk approach, taking into account safety, efficacy, ease of use and accessibility to the patient. Read More

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http://dx.doi.org/10.1080/10837450.2019.1609499DOI Listing

Safe and sustained expression of human iduronidase after adeno-associated virus 9 intrathecal administration in infant rhesus monkeys.

Hum Gene Ther 2019 Apr 24. Epub 2019 Apr 24.

University of Pennsylvania, Gene Therapy Program , Suite 2000 TRL , 125 S. 31st Street , Philadelphia, Pennsylvania, United States , 19104.

Many neuropathic diseases cause early, irreversible neurologic deterioration, which warrants therapeutic intervention during the first months of life. In the case of mucopolysaccharidosis type I (MPS I), a recessive lysosomal storage disorder that results from a deficiency of the lysosomal enzyme, α-l-iduronidase (IDUA), one of the most promising treatment approaches is to restore enzyme expression through gene therapy. Specifically, administering neurotropic adeno-associated virus (AAV) encoding IDUA into the cerebrospinal fluid (CSF) via suboccipital administration has demonstrated remarkable efficacy in large animals. Read More

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http://dx.doi.org/10.1089/hum.2019.012DOI Listing

Loss of consciousness and altered mental state predicting depressive and post-concussive symptoms after mild traumatic brain injury.

Brain Inj 2019 Apr 24:1-6. Epub 2019 Apr 24.

f Department of Emergency Medicine , University of Michigan Medical School , Ann Arbor , MI , USA.

Objective: Limited studies exist on the association between loss of consciousness (LOC) and altered mental state (AMS) and development of depressive and post-concussive symptoms within six months after mild traumatic brain injury (mTBI). We tested the hypothesis that presence of both LOC and AMS predict the highest risk of symptoms within the first six months post-mTBI compared to either variable alone, and that LOC alone is more strongly associated with these symptoms.

Research Design: We analyzed data from 407 subjects with mTBI from the Head injury Serum Markers for Assessing Response to Trauma (HeadSMART) cohort, a prospective cohort of patients post-TBI presenting to two urban emergency departments. Read More

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http://dx.doi.org/10.1080/02699052.2019.1606447DOI Listing
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