715,447 results match your criteria Pediatric Allergy Immunology and Pulmonology[Journal]


[The application of pediatric voice handicap index in children with voice disorders].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):121-125

Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

To access the influence of voice disorders on children's voice-related quality of life through the parental version of pediatric voice handicap index (pVHI). From April 2017 to March 2018, a total of 192 children with voice disorders (dysphonic group) and 111 children without voice disorders (control group) were enrolled in this work. Parents of children in both groups were asked for fill out the questionnaire containing the parental version of pVHI and the data of non-normal distribution were analyzed by Mann-Whitney test. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.005DOI Listing
February 2019

A novel in vitro model of primary human pediatric lung epithelial cells.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

Division of Neonatology, University of Rochester Medical Center, Rochester, NY, USA.

Background: Current in vitro human lung epithelial cell models derived from adult tissues may not accurately represent all attributes that define homeostatic and disease mechanisms relevant to the pediatric lung.

Methods: We report methods for growing and differentiating primary Pediatric Human Lung Epithelial (PHLE) cells from organ donor infant lung tissues. We use immunohistochemistry, flow cytometry, quantitative RT-PCR, and single cell RNA sequencing (scRNAseq) analysis to characterize the cellular and transcriptional heterogeneity of PHLE cells. Read More

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http://dx.doi.org/10.1038/s41390-019-0340-9DOI Listing
February 2019

Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Background: Adverse developmental programming by early-life exposures might account for higher blood pressure (BP) in children born extremely preterm. We assessed associations between nutrition, growth and hyperglycemia early in infancy, and BP at 6.5 years of age in children born extremely preterm. Read More

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http://dx.doi.org/10.1038/s41390-019-0341-8DOI Listing
February 2019

Therapeutic drug monitoring of teicoplanin using an LC-MS/MS method: Analysis of 421 measurements in a naturalistic clinical setting.

J Pharm Biomed Anal 2019 Feb 4;167:161-165. Epub 2019 Feb 4.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Pharmacology & Therapeutics, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Teicoplanin is a glycopeptide antibiotic used for treatment of severe Gram-positive bacterial infection. The aim of this study was to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for therapeutic drug monitoring (TDM) of teicoplanin and to review our clinical experience. We established an LC-MS/MS method to analyze serum concentration of teicoplanin using simple protein precipitation with a 5 min run time for each sample. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.001DOI Listing
February 2019

Venous Physiology Predicts Dehydration in the Pediatric Population.

J Surg Res 2019 Feb 15;238:232-239. Epub 2019 Feb 15.

Department of Pediatric Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: No standard dehydration monitor exists for children. This study attempts to determine the utility of Fast Fourier Transform (FFT) of a peripheral venous pressure (PVP) waveform to predict dehydration.

Materials And Methods: PVP waveforms were collected from 18 patients. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.036DOI Listing
February 2019

Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.

Seizure 2019 Jan 28;66:26-30. Epub 2019 Jan 28.

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Electronic address:

Purpose: This study aimed to investigate the genetic etiology of epilepsy in a cohort of Chinese children.

Methods: Targeted next-generation sequencing (NGS) was performed for 120 patients with unexplained epilepsy, including 71 patients with early-onset epileptic encephalopathies, and 16 patients with Dravet syndrome (including three patients with a Dravet-like phenotype) but without SCN1A pathogenic variants.

Results: Pathogenic variants of 14 genes were discovered in 22 patients (18%). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.025DOI Listing
January 2019

Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.

Cancer Epidemiol 2019 Feb 15;59:158-165. Epub 2019 Feb 15.

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden. Electronic address:

Background: Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.

Aim: To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.

Material/methods: We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. Read More

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http://dx.doi.org/10.1016/j.canep.2019.01.022DOI Listing
February 2019

Maternal high-fat diet impairs leptin signaling and up-regulates type-1 cannabinoid receptor with sex-specific epigenetic changes in the hypothalamus of newborn rats.

Psychoneuroendocrinology 2019 Feb 8;103:306-315. Epub 2019 Feb 8.

Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, RJ, Brazil.

Maternal nutritional imbalances trigger developmental adaptations involving early epigenetic mechanisms associated with adult chronic disease. Maternal high-fat (HF) diet promotes obesity and hypothalamic leptin resistance in male rat offspring at weaning and adulthood. Leptin resistance is associated with over activation of the endocannabinoid system (ECS). Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.02.004DOI Listing
February 2019

Development and psychometric properties of the assessment questionnaire for the process of the tutorial action plan.

Nurse Educ Today 2019 Feb 13;76:109-117. Epub 2019 Feb 13.

Campus Docent Sant Joan de Déu-Fundació Privada, School of Nursing, University of Barcelona, Barcelona, Spain; Research Group GIES (Grupo de investigación en Enfermería, Educación y Sociedad), Spain; Research Committee of the Campus Docent SJD, Spain; Neonatal and Pediatric Hospital Pedagogy Research Group, Spain.

Background: Internationally, most countries recognize the right of the student to receive assistance from teachers and tutors. The Tutorial Action Plan is a teaching tool that aims to promote academic, personal, and professional development in students. It is important to monitor this process of tutoring to be able to provide appropriate guidance to nursing students throughout their education. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.02.002DOI Listing
February 2019

The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Patient registries are instrumental for clinical research in rare diseases. They help to achieve a sufficient sample size for epidemiological and clinical research and to assess the feasibility of clinical trials. The European Society for Immunodeficiencies (ESID) registry currently comprises information on >25,000 patients with inborn errors of immunity (IEI). Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.004DOI Listing
February 2019

Do youth ask asthma providers the questions they want to ask?

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Cecil G. Sheps, Center for Health Services Research, University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1016/j.jaip.2019.02.005DOI Listing
February 2019

Screening for inhalation technique errors with electronic medication monitors.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Propeller Health, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.02.006DOI Listing
February 2019

Adverse events in oral immunotherapy for the desensitization of cow's milk allergy in children: a randomized controlled trial.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Allergy and Immunology, Department of Pediatrics, McGill University, Montreal, QC, Canada. Electronic address:

Background: This study focuses on side effects of cow's milk oral immunotherapy (CM-OIT) using consensus definitions of food-induced anaphylaxis.

Objective: To evaluate the risk of allergic reactions (ARs) and to identify risk factors associated with higher risk of anaphylactic ARs (AARs) during CM-OIT in children.

Methods: Clinical charts of children receiving CM-OIT were carefully reviewed. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.007DOI Listing
February 2019

Increased proportions of γδ T lymphocytes in atypical SCID associate with disease manifestations.

Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.006DOI Listing
February 2019

Clinical Features and Prognostic Factors of Pediatric Spine Giant Cell Tumors: report of 31 clinical cases in a single center.

Spine J 2019 Feb 15. Epub 2019 Feb 15.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background Context: Giant cell tumors (GCTs) of the bone are benign but locally aggressive. Pediatric spine giant-cell tumors (PSGCTs) have been infrequently reported in the literature because of the rarity of the disease.

Purpose: The purpose of this study was to define the overall occurrence rate of PSGCTs among all spinal GCTs in our center and investigate the clinical features and prognostic factors of this rare disease. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.02.011DOI Listing
February 2019

NFX1-123 is highly expressed in cervical cancer and increases growth and telomerase activity in HPV 16E6 expressing cells.

Cancer Lett 2019 Feb 15. Epub 2019 Feb 15.

Seattle Children's Research Institute, Center for Global Infectious Disease Research, 1900 Ninth Ave., Seattle, WA, 98101-1309, USA; Dept. of Global Health, Pathobiology Program, University of Washington, Seattle, WA, USA; Dept. of Pediatrics, Div. of Adolescent Medicine, University of Washington, Seattle, WA, USA. Electronic address:

A significant contributor to women's cancer mortality worldwide is cervical cancer, which is caused by high-risk human papillomavirus (HR HPV). The two viral oncoproteins of HR HPV, E6 and E7, partner with host cell proteins to target oncogenic proteins and pathways. Previously, we have shown HR HPV type 16 E6 (16E6) interacts with the host protein NFX1-123 to target telomerase and cellular immortalization, requiring NFX1-123 to fully upregulate telomerase activity. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.024DOI Listing
February 2019

Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway.

Toxicology 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address:

This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms. Pregnant rats were intragastrically administered caffeine (30, 60, and 120 mg/kg.d) on gestational day (GD) 9-20. Read More

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http://dx.doi.org/10.1016/j.tox.2019.02.008DOI Listing
February 2019

Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models.

Eur J Pharm Biopharm 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

Elastin-like polypeptide (ELP) nanoparticles are a versatile platform for targeted drug delivery. As for any type of nanocarrier system an important challenge remains the ability of deep (tumor) tissue penetration. In this study, ELP particles with controlled surface density of the cell-penetrating peptide (CPP) octa-arginine (R8) were created by temperature-induced co-assembly. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.010DOI Listing
February 2019

House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation.

Microb Pathog 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology, Immunology and Molecular Genetics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. Electronic address:

Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of the most common indoor allergens and are a significant driver of allergic disease. Respiratory infections are known factors in acute exacerbations of asthma but the impact of allergen on the pathogen is not well understood. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.019DOI Listing
February 2019

Biological properties of modified bioactive glass on dental pulp cells.

J Dent 2019 Feb 15. Epub 2019 Feb 15.

School and Hospital of Stomatology, Peking University, #22 Zhongguancun Nandajie, Haidian District, Beijing, 100081, China. Electronic address:

Dental caries is a bacteria-caused condition classified among the most common chronic diseases worldwide. Treatment of dental caries implies the use of materials having regenerative and anti-bacterial properties, and controlling inflammation is critical for successful endodontic regeneration.

Objectives: The aim of this study was to fabricate and characterize a novel composite incorporating sol-gel derived silver-doped bioactive glass (BG) in a chitosan (CS) hydrogel at a 1:1 weight ratio(Ag-BG/CS). Read More

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http://dx.doi.org/10.1016/j.jdent.2019.01.017DOI Listing
February 2019

Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma.

J Control Release 2019 Feb 15. Epub 2019 Feb 15.

Departments of Pediatrics, Physiology and Pharmacology, University of Montréal, Montréal, QC, Canada. Electronic address:

Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are short non-coding single-stranded RNAs that affect a vast range of biological processes. Previously, we focused on the regulatory role of miR-181a during cancer development and progression. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.014DOI Listing
February 2019

Infected Necrotizing Pancreatitis: Evolving Interventional Strategies from Minimally Invasive Surgery to Endoscopic Therapy - Evidence Mounts But One Size Does Not Fit All.

Gastroenterology 2019 Feb 15. Epub 2019 Feb 15.

Professor of Medicine and Pediatrics, Chief, Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1053/j.gastro.2019.02.015DOI Listing
February 2019

Primary Oral Presentation of Sarcoidosis in a Pediatric Patient.

J Oral Maxillofac Surg 2019 Jan 23. Epub 2019 Jan 23.

Associate Professor, Department of Pediatric Rheumatology, Children's of Alabama, Birmingham, AL.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology that commonly affects the lungs, lymph nodes, and skin. The disease often presents in patients between the third and sixth decade and its pathology is defined by the presence of noncaseating granulomas within organs throughout the body. Oral and neurologic involvement of sarcoid is extremely rare and occurs in approximately 1% and 5% of patients with the disease, respectively. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.018DOI Listing
January 2019

Mice missing Cnr1 and Cnr2 show implantation defects.

Endocrinology 2019 Feb 18. Epub 2019 Feb 18.

Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Cannabinoid/endocannabinoid signaling is primarily mediated by CB1 (encoded by Cnr1) and/or CB2 (encoded by Cnr2). Here we show that Cnr1-/-Cnr2-/- mice are subfertile due to compromised implantation. Upon implantation, the epithelium is smooth and adhered to the blastocyst trophectoderm within the implantation chamber (crypt) in wild type mice, whereas the epithelium in Cnr1-/-Cnr2-/- mice is ruffled which compromises appropriate blastocyst-uterine interactions. Read More

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http://dx.doi.org/10.1210/en.2019-00024DOI Listing
February 2019

[Prevalence of autism spectrum disorders in USA, Europe and Spain: coincidences and discrepancies].

Medicina (B Aires) 2019 ;79 Suppl 1:4-9

Unidad de Neurología Infantil, Hospital Universitario Central de Asturias, Oviedo, España.

Autism spectrum disorders are a heterogeneous group of disorders that share the presence of two core symptoms: problems in social interaction / communication and the tendency to present restricted interests and repetitive behavior. Over the last years, several epidemiologic studies have been published by different authors in diverse countries, having all of them shown two common characteristics: a global increase in the prevalence rates of autism spectrum disorders, and the existence of a great geographical variability no only between geographical areas, but also within the same geographical areas. At the present manuscript, we analyze some of the most recent prevalence data published in USA and some European countries (including Spain). Read More

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January 2019

Does drug induced sleep endoscopy-directed surgery improve polysomnography measures in children with Down Syndrome and obstructive sleep apnea?

Acta Otolaryngol 2018 Nov;138(11):1009-1013

c Pediatric Otolaryngology , Seattle Children's Hospital , Seattle , WA , USA.

Background: Children with Down Syndrome (DS) and obstructive sleep apnea (OSA) are difficult to treat, as first line therapies may not lead to significant improvement. Drug-induced sleep endoscopy (DISE) directed surgery may be particularly beneficial for these patients.

Objective: To assess change in polysomnography (PSG) measures of patients with DS who underwent DISE-directed surgery. Read More

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http://dx.doi.org/10.1080/00016489.2018.1504169DOI Listing
November 2018

Molecular Design of Sequence-minimized, Structure-optimized, and Hydrocarbon-stapled Helix-Helix Interactions in the Trimer-of-Hairpins Motif of Pediatric Pneumonia RSV-F Protein.

Chem Biol Drug Des 2019 Feb 18. Epub 2019 Feb 18.

Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.

The respiratory syncytial virus fusion (RSV-F) protein is a primary target for vaccine and drug development against respiratory infection and pediatric pneumonia. The RSV-F core forms a trimer-of-hairpins (TOH) motif in post-fusion conformation, which is characterized by a six-helix bundle (6HB) where the three N-terminal HRn helices define a central coiled-coil, while three C-terminal HRc helices pack on the coiled-coil surface in an antiparallel manner. Here, one tightly packed HRn-HRc helix-helix interaction is stripped from the 6HB, which represents the minimum unit of RSV-F TOH motif. Read More

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http://dx.doi.org/10.1111/cbdd.13501DOI Listing
February 2019

Nasal IgE Production in Allergic Rhinitis: Impact of Rhinovirus Infection.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

Departments of Medicine, University of Virginia Health System, Charlottesville, VA, 22908.

Background: Rhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state and these exacerbations can be mitigated via administration of anti-IgE.

Objective: We investigated the presence of local IgE production in the nose of allergic and non-allergic subjects and assessed whether this was enhanced by RV.

Methods: Local production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples. Read More

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http://dx.doi.org/10.1111/cea.13372DOI Listing
February 2019

A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections.

JAMA Pediatr 2019 Feb 18. Epub 2019 Feb 18.

Division of Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan.

Importance: In young febrile infants, serious bacterial infections (SBIs), including urinary tract infections, bacteremia, and meningitis, may lead to dangerous complications. However, lumbar punctures and hospitalizations involve risks and costs. Clinical prediction rules using biomarkers beyond the white blood cell count (WBC) may accurately identify febrile infants at low risk for SBIs. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2018.5501DOI Listing
February 2019

2018 Update on Pediatric Medical Overuse: A Review.

JAMA Pediatr 2019 Feb 18. Epub 2019 Feb 18.

Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Importance: Efforts to combat medical overuse have gained traction in recent years, but success has been intermittent and shortcomings have been recognized. A commitment to a strong evidence base is needed to more broadly engage clinicians and reduce overuse.

Observations: A structured MEDLINE search and a manual review of tables of contents from selected high-impact journals was performed to identify original research published in 2017 relevant to pediatric overuse. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2018.5550DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

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http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Accuracy of presepsin in neonatal sepsis: systematic review and meta-analysis.

Expert Rev Anti Infect Ther 2019 Feb 18. Epub 2019 Feb 18.

e Division of Pediatric Infectious Disease, Meyer University Children's Hospital, Department of Health Sciences , University of Florence , Florence , Italy .

Introduction: Neonatal sepsis represents a major cause of morbidity and mortality in neonates. No diagnostic test has been demonstrated to be sufficiently accurate to confirm or exclude neonatal sepsis. This study aimed to evaluate the diagnostic accuracy of presepsin (P-SEP) for neonatal sepsis. Read More

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https://www.tandfonline.com/doi/full/10.1080/14787210.2019.1
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http://dx.doi.org/10.1080/14787210.2019.1584037DOI Listing
February 2019
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Continued attendance for paediatric weight management: A multicentre, qualitative study of parents' reasons and facilitators.

Clin Obes 2019 Feb 18:e12304. Epub 2019 Feb 18.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

Although prolonged engagement in paediatric weight management (PWM) is associated with positive treatment outcomes, little is currently known about enablers of long-term programme attendance. The purpose of our study was to explore families' reasons for and facilitators of their continued attendance at health services for PWM. Semi-structured, individual interviews were conducted with parents of children (10-17 year old; body mass index ≥85th percentile) who completed the active phase of treatment in one of four Canadian multidisciplinary clinics for PWM. Read More

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http://dx.doi.org/10.1111/cob.12304DOI Listing
February 2019

Cardiometabolic health in Turner syndrome.

Am J Med Genet C Semin Med Genet 2019 Feb 18. Epub 2019 Feb 18.

Children's Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Blvd., MS #61, Los Angeles, California.

Individuals with Turner syndrome (TS) have a higher morbidity and mortality compared to the general population. Diabetes and cardiovascular disease are the major contributors to this burden. Precursors to diabetes and cardiovascular disease make up what is known as metabolic syndrome, including abdominal obesity, hypertension, dyslipidemia, and elevated fasting glucose. Read More

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http://dx.doi.org/10.1002/ajmg.c.31678DOI Listing
February 2019

The prevelance of mesiodens in a group of non-syndromic Turkish children: a radiographic study.

Eur Oral Res 2018 Sep 1;52(3):162-166. Epub 2018 Sep 1.

Department of Oral and Maxillofacial Surgery, İstanbul University, Faculty of Dentistry, İstanbul, Turkey.

Purpose: The aim of the present study is to determine the prevelance and clinical status of mesiodens in a group of non-syndromic Turkish children, with an analysis of the associated clinical-eruptive complications.

Materials And Methods: This study sample consists of 58142 pediatric patients'. Standard equipment and films were used in the suspected patients. Read More

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http://dx.doi.org/10.26650/eor.2018.456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365133PMC
September 2018

Clinical evaluation of dental enamel defects and oral findings in coeliac children.

Eur Oral Res 2018 Sep 1;52(3):150-156. Epub 2018 Sep 1.

Department of Basic Medical Sciences, Division of Biochemistry, Marmara University, Faculty of Dentistry, İstanbul, Turkey.

Purpose: To examine dental hard and soft tissue changes of coeliac children in order to increase the awareness of the pediatric dentists in prediagnosis of especially undiagnosed coeliac disease.

Materials And Methods: Sixty children, 28 (46.7%) boys and 32 (53. Read More

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http://dx.doi.org/10.26650/eor.2018.525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365134PMC
September 2018

Comparative evaluation of apical sealing ability of different root canal sealers.

Eur Oral Res 2018 Sep 1;52(3):117-121. Epub 2018 Sep 1.

Department of Pedodontics, Selçuk University, Faculty of Dentistry, Tokat, Turkey.

Purpose: The aim of this study was to compare the short and long term apical sealing ability of different root canal sealers.

Materials And Methods: Fifty-five extracted human anterior single-root teeth were used. The coronal part of each tooth was removed and the root canals were prepared with NiTi rotary instruments. Read More

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http://dx.doi.org/10.26650/eor.2018.438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365140PMC
September 2018

Point-of-care Ultrasound Diagnosis of Slipped Capital Femoral Epiphysis.

Clin Pract Cases Emerg Med 2019 Feb 22;3(1):81-82. Epub 2019 Jan 22.

University of Toronto, Hospital for Sick Children, Division of Pediatric Emergency Medicine, Department of Pediatrics, Toronto, Canada.

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http://dx.doi.org/10.5811/cpcem.2019.1.41357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366387PMC
February 2019

Acute Lymphoblastic Leukemia Presenting Solely as Low Back Pain.

Clin Pract Cases Emerg Med 2019 Feb 29;3(1):59-61. Epub 2019 Jan 29.

Dalhousie University, Department of Emergency Medicine, Halifax, Nova Scotia.

A 23-year-old man with acute lymphoblastic leukemia presented to the emergency department without any history of constitutional symptoms (fatigue, anorexia, or weight loss), dyspnea, bruising, or bleeding. Presentation of acute leukemia solely as musculoskeletal pathology is common in pediatric populations but rare among adult patients. Recognizing this presentation of acute leukemia in adult patients could help prevent delayed diagnoses. Read More

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http://dx.doi.org/10.5811/cpcem.2019.1.40699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366376PMC
February 2019

Ibuprofen-Induced Renal Tubular Acidosis.

Authors:
Toru Watanabe

Kidney Int Rep 2019 Feb 24;4(2):360. Epub 2018 Dec 24.

Department of Pediatrics, Niigata City General Hospital, Niigata City, Japan.

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http://dx.doi.org/10.1016/j.ekir.2018.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365401PMC
February 2019

Treatment of Severe Amlodipine Toxicity With Molecular Adsorbent Recirculating System.

Kidney Int Rep 2019 Feb 28;4(2):346-349. Epub 2018 Sep 28.

Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365306PMC
February 2019

Association of ficolin-2 (FCN2) functional polymorphisms and protein levels with rheumatic fever and rheumatic heart disease: relationship with cardiac function.

Arch Med Sci Atheroscler Dis 2018 15;3:e142-e155. Epub 2018 Dec 15.

Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Introduction: A role for ficolin (FCN) 2 gene polymorphisms in the pathogenesis of recurrent severe streptococcal infections and rheumatic carditis has been suggested. The aim of the study was to evaluate a possible relationship between single nucleotide polymorphisms located at positions -602 and -4 of the FCN2 gene and FCN2 serum levels and risk of development of rheumatic fever (RF) and rheumatic heart disease (RHD).

Material And Methods: Seventy-seven Caucasian Egyptian patients with RF were recruited with a control group of 43 healthy subjects. Read More

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http://dx.doi.org/10.5114/amsad.2018.80999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374577PMC
December 2018

Intima media thickness as an early predictor of atherosclerosis in Egyptian children with familial Mediterranean fever.

Arch Med Sci Atheroscler Dis 2018 7;3:e106-e111. Epub 2018 Aug 7.

Department of Pediatrics, National Research Centre, Dokki, Egypt.

Introduction: Familial Mediterranean fever (FMF) is an autosomal recessive disease. It is characterized by recurrent crises of fever and serosal inflammation. Although FMF patients are symptom free in between attacks, subclinical inflammation continues during the attack-free period. Read More

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http://dx.doi.org/10.5114/amsad.2018.77545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374578PMC

A case report of acute rheumatic fever and a brief review of the literature.

Arch Med Sci Atheroscler Dis 2018 28;3:e80-e82. Epub 2018 Jun 28.

Department of Pediatrics, Shanghai Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

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http://dx.doi.org/10.5114/amsad.2018.76825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374571PMC

The role of diagnostic cardiac catheterization for children with congenital heart diseases: local experience.

Authors:
Reham Wagdy

Arch Med Sci Atheroscler Dis 2018 28;3:e72-e79. Epub 2018 Jun 28.

Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Introduction: Despite the development of non-invasive tools of investigations for congenital heart diseases (CHDs), still the role of diagnostic cardiac catheterization (DCC) cannot be undermined. The study aimed to analyze the clinical profile of indicated CHDs cases at our center for DCC to evaluate the contribution of DCC in patients' management plans.

Material And Methods: The study checked files of cases performed DCC between 2011 and 2012 at the pediatric catheterization unit of Alexandria University Children's Hospital by the same operator. Read More

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http://dx.doi.org/10.5114/amsad.2018.76824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374569PMC

Kawasaki disease: a comprehensive review.

Arch Med Sci Atheroscler Dis 2018 21;3:e41-e45. Epub 2018 Mar 21.

Department of Pediatrics, Robert Reid Cabral Children's Hospital affiliated to the University Iberoamericana UNIBE, School of Medicine, Santo Domingo, Dominican Republic.

Kawasaki disease is an acute systemic vasculitis that was first reported in 1961. Over the last 5 decades multiple papers have been published to further understand this disease. The diagnosis of Kawasaki disease is made based on the clinical findings. Read More

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http://dx.doi.org/10.5114/amsad.2018.74522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374576PMC

Left ventricular dysfunction by conventional and tissue Doppler echocardiography in pediatric hemodialysis patients: relation with plasma brain natriuretic peptide levels.

Arch Med Sci Atheroscler Dis 2018 7;3:e18-e28. Epub 2018 Feb 7.

Pediatrics Department and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.

Introduction: Tissue Doppler imaging (TDI) is a relatively new echocardiography method in children with chronic kidney disease (CKD). The aims of this study were to evaluate left ventricular (LV) diastolic function in pediatric CKD patients using conventional pulsed-wave Doppler echocardiography (cPWD) and TDI methods and correlate them with BNP levels.

Material And Methods: Thirty children on regular hemodialysis (HD) were included. Read More

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http://dx.doi.org/10.5114/amsad.2018.73277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374560PMC
February 2018

Severe Crohn's Disease Manifestations in a Child with Cystathionine β-Synthase Deficiency.

ACG Case Rep J 2018 5;5:e93. Epub 2018 Dec 5.

King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Inflammatory bowel diseases (IBDs) are idiopathic autoimmune diseases that are characterized by inflammation of both the small and large intestine. Although IBD is common in the general population, the pathophysiology remains ambiguous. Clear understanding of IBD pathophysiology would be a major step toward curative treatment in the future. Read More

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http://dx.doi.org/10.14309/crj.2018.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358571PMC
December 2018
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