136,625 results match your criteria Patient Safety & Quality Healthcare [Journal]


Pedicle screw insertion with patient-specific 3D-printed guides based on low-dose CT scan is more accurate than free-hand technique in spine deformity patients: a prospective, randomized clinical trial.

Eur Spine J 2019 Apr 20. Epub 2019 Apr 20.

GSpine4, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Background: Screw misplacement incidence can be as high as 15-30% in spine deformity surgery, with possible devastating consequences. Some technical solutions to prevent misplacement require expensive devices. MySpine comprises a low-dose CT scan of the patient's spine to build a virtual model of the spine to plan the screw trajectories and a 3D-printed patient-specific guide system to prepare the screw trajectories and to implant the screws in the vertebrae in order to increase reproducibility and safety of the implants. Read More

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http://dx.doi.org/10.1007/s00586-019-05978-3DOI Listing

Sunitinib in pediatric patients with advanced gastrointestinal stromal tumor: results from a phase I/II trial.

Cancer Chemother Pharmacol 2019 Apr 20. Epub 2019 Apr 20.

Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.

Background: Sunitinib is approved for treatment of adults with imatinib-resistant gastrointestinal stromal tumor (GIST) or imatinib intolerance.

Methods: This single-arm, multicenter, multinational phase I/II clinical trial (NCT01396148) enrolled eligible patients aged 6 to < 18 years with advanced, unresectable GIST with non-mutant KIT, or who demonstrated disease progression or intolerance to imatinib. Patients received sunitinib 15 mg/m per day, 4-weeks-on/2-weeks-off (schedule 4/2), for ≤ 18 cycles over 24 months. Read More

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http://link.springer.com/10.1007/s00280-019-03814-5
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http://dx.doi.org/10.1007/s00280-019-03814-5DOI Listing
April 2019
1 Read

Parental home removal of urethral catheters after urological surgery-a prospective benchmarking study.

Authors:
S Braungart A Goyal

J Pediatr Urol 2019 Mar 29. Epub 2019 Mar 29.

Department of Paediatric Surgery and Urology, Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Introduction: Many urological operations require placement of a urethral Foley catheter. The catheter often needs to remain in situ for a period of time after discharge; and patients subsequently require either a further hospital admission or community nurse review for catheter removal. Parents can easily remove the catheter at home by cutting the balloon port. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.03.018DOI Listing

Bug off! Severe toxicity following inhalational exposure to N, N-diethyl-meta-toluamide (DEET).

Am J Emerg Med 2019 Apr 12. Epub 2019 Apr 12.

Spectrum Health - Michigan State University Emergency Medicine Residency Program, Grand Rapids, MI, United States of America. Electronic address:

N, N-diethyl-meta-toluamide (DEET) is an insect repellent currently used by millions of people since 1956. DEET has an excellent safety profile and has remarkable protection against mosquitoes, ticks and various other arthropods. Toxicity is unusual, and is generally associated with incorrect, or overuse of the product. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.04.019DOI Listing

ECG interpretation skill acquisition: A review of learning, teaching and assessment.

J Electrocardiol 2019 Apr 12. Epub 2019 Apr 12.

School of Nursing, Ulster University, Shore Road, Jordanstown Campus, BT37 0QB, United Kingdom of Great Britain and Northern Ireland; Institute of Nursing and Health Research, Ulster University, Shore Road, Jordanstown Campus, BT37 0QB, United Kingdom of Great Britain and Northern Ireland.

The recording of 12 lead electrocardiograms (ECG) is one of the most useful and commonly performed medical procedures. ECGs are used in diagnosis, risk-stratification management decision-making, and assessment in response to therapy. The correct interpretation of 12 lead ECG recordings is complex and clinically challenging with misinterpretation having the potential to result in poor outcomes or even patient fatality. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2019.03.010DOI Listing

Long-term results of a multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (JACCRO CC-04: SHOGUN Trial).

Radiother Oncol 2019 May 26;134:199-203. Epub 2019 Feb 26.

Japan Clinical Cancer Research Organization, Tokyo, Japan.

Purpose: The study was designed to evaluate the safety and efficacy of adding oxaliplatin to py (CRT) with S-1 in patients with locally advanced rectal carcinoma (LARC). We report here the final results of the study.

Patients And Methods: Patients with histopathologically confirmed LARC (cT3-T4, any N) were eligible. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.006DOI Listing
May 2019
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Risk-adapted stereotactic ablative radiotherapy for central and ultra-central lung tumours.

Radiother Oncol 2019 May 18;134:178-184. Epub 2019 Feb 18.

Centre Hospitalier de l'Université de Montréal, Canada.

Background: SABR is a widely accepted treatment for early-stage lung cancer but there are safety concerns for central and ultra-central tumours. Herein we report our experience using risk-adapted fractionation (prescribed doses: 40-60 Gy in 3-8 fractions) with prioritization of dose to organs at risk.

Methods: Patient declining or unsuitable for surgery with primitive or recurrent lung cancer were included. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.01.035DOI Listing

In-vivo treatment accuracy analysis of active motion-compensated liver SBRT through registration of plan dose to post-therapeutic MRI-morphologic alterations.

Radiother Oncol 2019 May 15;134:158-165. Epub 2019 Feb 15.

University Medical Center Schleswig-Holstein, Department of Radiation Oncology, Kiel, Germany; Saphir Radiosurgery Center, Güstrow, Germany.

Background/purpose: In-vivo-accuracy analysis (IVA) of dose-delivery with active motion-management (gating/tracking) was performed based on registration of post-radiotherapeutic MRI-morphologic-alterations (MMA) to the corresponding dose-distributions of gantry-based/robotic SBRT-plans.

Methods: Forty targets in two patient cohorts were evaluated: (1) gantry-based SBRT (deep-inspiratory breath-hold-gating; GS) and (2) robotic SBRT (online fiducial-tracking; RS). The planning-CT was deformably registered to the first post-treatment contrast-enhanced T1-weighted MRI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01678140193002
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http://dx.doi.org/10.1016/j.radonc.2019.01.023DOI Listing
May 2019
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Interventional oncology treatments for unresectable early stage HCC in patients with a high risk for intraprocedural bleeding: Is a single-step combined therapy safe and feasible?

Eur J Radiol 2019 May 23;114:32-37. Epub 2019 Feb 23.

Fondazione Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radiologia, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Roma, Italy; Università Cattolica del Sacro Cuore, Istituto di Radiologia, Roma, Italy.

Purpose: This study was designed to assess the feasibility and safety of a single-step combined therapy using radiofrequency ablation and transarterial chemoembolization (RFA + TACE) in patients with hepatocellular carcinoma (HCC) and uncontrolled coagulopathy. The study also aimed to compare the effectiveness of this approach with TACE alone, performed in a control group.

Material And Methods: One hundred and forty-three consecutive cirrhotic patients having a single HCC < 8 cm were enrolled in this observational prospective single-center study from January 2010 to June 2017 and were divided, according to coagulation tests, into three groups (A: low risk; B: intermediate risk and C: high risk of bleeding). Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.02.030DOI Listing

A case report of an asymptomatic male child with multiple entero-enteric fistulae post multiple magnet ingestion.

Int J Surg Case Rep 2019 Apr 9;58:50-53. Epub 2019 Apr 9.

Pediatric Surgery Department, Cairo University Specialized Pediatric Hospital, Cairo, Egypt.

Introduction: Foreign body ingestion cases are very common in children. They usually present with obvious symptoms allowing proper diagnosis and management; however, magnet ingestion can be asymptomatic. This disorder is considered uncommon as well as challenging to diagnose before complications of intestinal obstruction or peritonitis occur due to entrapment of intestinal walls in the magnetic field. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.043DOI Listing

Perioperative Morbidity of Gastrectomy During CRS-HIPEC: An ACS-NSQIP Analysis.

J Surg Res 2019 Apr 17;241:31-39. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Formal gastrectomy is occasionally required to achieve complete cytoreduction for patients with peritoneal surface malignancies. In addition, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with gastric cancer is increasingly being explored. Nevertheless, data on the safety of gastrectomy at the time of CRS-HIPEC are limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193015
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http://dx.doi.org/10.1016/j.jss.2019.03.036DOI Listing
April 2019
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Study Protocol for a Prospective, Multicenter, Randomized, Open-Label, Parallel-Group Clinical Trial Comparing the Efficacy and Safety of a Needle-Free Insulin Injector and a Conventional Insulin Pen in Controlling Blood Glucose Concentrations in Chinese Patients with Type 2 Diabetes Mellitus (The FREE Study).

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

Department of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Introduction: China has the largest number of diabetic patients in the world. In the past 2 decades, the prevalence of diabetes in China has increased dramatically, and the current status of diabetes control in the diabetic population is not satisfactory. Although insulin is currently recognized in diabetes treatment guidelines as the therapeutic option for patients not adequately controlled by diet/exercise and oral agents, the proportion of patients with type 2 diabetes using insulin is still very low, and the time when insulin therapy is initiated is relatively late. Read More

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http://dx.doi.org/10.1007/s12325-019-00951-4DOI Listing

Intravenous Oxycodone Versus Other Intravenous Strong Opioids for Acute Postoperative Pain Control: A Systematic Review of Randomized Controlled Trials.

Pain Ther 2019 Apr 19. Epub 2019 Apr 19.

Mundipharma Singapore Holding Pte. Ltd., Singapore, Singapore.

Introduction: Optimal pain management is crucial to the postoperative recovery process. We aimed to evaluate the efficacy and safety of intravenous oxycodone with intravenous fentanyl, morphine, sufentanil, pethidine, and hydromorphone for acute postoperative pain.

Methods: A systematic literature search of PubMed, Cochrane Library, and EMBASE databases was performed for randomized controlled trials published from 2008 through 2017 (inclusive) that evaluated the acute postoperative analgesic efficacy of intravenous oxycodone against fentanyl, morphine, sufentanil, pethidine, and hydromorphone in adult patients (age ≥ 18 years). Read More

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http://dx.doi.org/10.1007/s40122-019-0122-4DOI Listing

Equivalent Peri-Operative Outcomes for Laparoscopic Roux-En-Y Gastric Bypass Patients Discharged on Post-Operative Day One.

Obes Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Bariatric and Foregut Surgery, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA, 17822, USA.

Background: Previous studies have evaluated the safety of post-operative day one (POD #1) discharge after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery. Few studies, however, have evaluated the impact of a standardized POD #1 discharge pathway on peri-operative outcomes. This study aims to evaluate peri-operative outcomes after implementation of an enhanced recovery pathway for RYGB patients. Read More

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http://link.springer.com/10.1007/s11695-019-03884-7
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http://dx.doi.org/10.1007/s11695-019-03884-7DOI Listing
April 2019
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'They do not care how much you know until they know how much you care': a qualitative meta-synthesis of patient experience in the emergency department.

Emerg Med J 2019 Apr 19. Epub 2019 Apr 19.

School of Nursing and Midwifery, Faculty of Health and Human Sciences, University of Plymouth Faculty of Health and Human Sciences, Plymouth, UK.

Background: Patient experience is positively associated with both clinical effectiveness and patient safety and should be a priority for emergency care providers. While both quantitative and qualitative approaches can be used to evaluate patient experience in the emergency department (ED), the latter is well aligned to develop a detailed understanding of features influencing the lived experience of ED patients. This study aimed to systematically review the literature of qualitative studies to identify determinants of adult patient experience in the ED. Read More

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http://dx.doi.org/10.1136/emermed-2018-208156DOI Listing

Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study.

Lancet Haematol 2019 Apr 16. Epub 2019 Apr 16.

Hospital Universitario La Paz, Autónoma University, Madrid, Spain.

Background: Emicizumab, a subcutaneously administered, humanised, bispecific, monoclonal antibody, is approved to treat people with haemophilia A of all ages with and without coagulation factor VIII (FVIII) inhibitors. HAVEN 4 assessed emicizumab prophylaxis administered as one dose every 4 weeks in adults and adolescents with haemophilia A, regardless of FVIII inhibitor status.

Methods: In this phase 3, multicentre, open-label, two-stage study, patients aged 12 years and older with severe congenital haemophilia A (<1% of normal FVIII activity in blood) or haemophilia A with FVIII inhibitors, undergoing treatment with either FVIII concentrates or bypassing agents were recruited from three sites in Japan and Spain for a run-in cohort, and from 17 sites in Australia, Belgium, Japan, Poland, Spain, and the USA for a subsequent expansion cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523026193005
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http://dx.doi.org/10.1016/S2352-3026(19)30054-7DOI Listing
April 2019
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Optimal dilation time for combined small endoscopic sphincterotomy and balloon dilation for common bile duct stones: a multicentre, single-blinded, randomised controlled trial.

Lancet Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China; Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer Center of Lanzhou University, Lanzhou, China; Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China. Electronic address:

Background: Endoscopic sphincterotomy is the established treatment for common bile duct stones. Balloon dilation offers an alternative. Prolonged dilation (300 s) with a 10 mm diameter balloon decreases the occurrence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30075-5DOI Listing

Association of State Laws With Influenza Vaccination of Hospital Personnel.

Am J Prev Med 2019 Apr 16. Epub 2019 Apr 16.

Division of Healthcare Quality Promotion, National Center for Emerging Infectious and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Introduction: Healthcare personnel influenza vaccination can reduce influenza illness and patient mortality. State laws are one tool promoting healthcare personnel influenza vaccination.

Methods: A 2016 legal assessment in 50 states and Washington DC identified (1) assessment laws: mandating hospitals assess healthcare personnel influenza vaccination status; (2) offer laws: mandating hospitals offer influenza vaccination to healthcare personnel; (3) ensure laws: mandating hospitals require healthcare personnel to demonstrate proof of influenza vaccination; and (4) surgical masking laws: mandating unvaccinated healthcare personnel to wear surgical masks during influenza season. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193005
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http://dx.doi.org/10.1016/j.amepre.2019.01.011DOI Listing
April 2019
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Bariatric Surgery: Safety, Efficacy, Disease State, Collaboration, Future.

J Arthroplasty 2019 Mar 27. Epub 2019 Mar 27.

Chair, General Surgery, Cleveland Clinic, Weston, FL.

Obesity provides an opportunity for bariatric and orthopedic surgeons to collaborate through emphasis on safety, effectiveness and patient experience. A value equation can be offered for combining weight loss for the patient with obesity and joint disease. Read More

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http://dx.doi.org/10.1016/j.arth.2019.03.040DOI Listing

The dual-staged pathway for closure in cloacal exstrophy: Successful evolution in collaborative surgical practice.

J Pediatr Surg 2019 Apr 8. Epub 2019 Apr 8.

Robert D. Jeffs Division of Pediatric Urology, James Buchanan Brady Urological Institutions, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Charlotte Bloomberg Children's Hospital, Baltimore, MD, USA. Electronic address:

Introduction: A successful abdominal wall and bladder closure is critical in the management of cloacal exstrophy (CE). This study examines closure outcomes and practices over the last 4 decades at the authors' institution. Beginning in 1995, the authors' institution standardized CE closure and management with the Dual-Staged Pathway (DSP). Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.005DOI Listing

Complementary and alternative medicine, medical liability and the proper standard of care.

Complement Ther Clin Pract 2019 May 15;35:183-188. Epub 2019 Feb 15.

Faculty of Law, University of Macau, Macau, China. Electronic address:

Complementary and alternative medicine raises growing interests among population. Patients have the right to reject conventional medicine and instead look for a different treatment, even if sometimes is a placebo. However, currently this risks being a reckless decision, since the way complementary and alternative medicine is being provided leaves space for fraudulent practices, misleading information, wrong diagnosis, improper treatments and thus severe patient's injuries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17443881183082
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http://dx.doi.org/10.1016/j.ctcp.2019.02.009DOI Listing
May 2019
1 Read

Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Sociology, Social Work and Public Health, Universidad de Huelva, 21071 Huelva, Spain.

The prevalence, relationships and outcomes of sarcopenia and frailty in polypathological patients remain unknown. We performed a multicenter prospective observational study in six hospitals in order to assess prevalence, clinical features, outcome and associated risk factors of sarcopenia and frailty in a hospital-based population of polypathological patients. The cohort was recruited by performing prevalence surveys every 14 days during the inclusion period (March 2012-June 2016). Read More

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https://www.mdpi.com/2077-0383/8/4/535
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http://dx.doi.org/10.3390/jcm8040535DOI Listing
April 2019
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Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus.

Nutrients 2019 Apr 18;11(4). Epub 2019 Apr 18.

Director of Cardiovascular and Genetic Epidemiology, Intermountain Medical Center Heart Institute, and Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84107, USA.

Intermittent fasting is increasing in popularity as a means of losing weight and controlling chronic illness. Patients with diabetes mellitus, both types 1 and 2, comprise about 10% of the population in the United States and would likely be attracted to follow one of the many methods of intermittent fasting. Studies on the safety and benefits of intermittent fasting with diabetes are very limited though, and health recommendations unfortunately today arise primarily from weight loss gurus and animal studies. Read More

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https://www.mdpi.com/2072-6643/11/4/873
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http://dx.doi.org/10.3390/nu11040873DOI Listing
April 2019
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Blinatumomab for Acute Lymphoblastic Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.

Patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) following allogeneic hematopoietic stem cell transplantation (alloHSCT) have a poor prognosis, and alternative therapies are needed for this patient population. Blinatumomab, a bispecific T-cell engager immunotherapy, was evaluated in an open-label, single-arm, phase 2 study of adults with R/R Philadelphia chromosomenegative B-cell precursor ALL and resulted in a complete remission (CR) or CR with partial hematologic recovery of peripheral blood counts (CRh) rate of 43% within 2 treatment cycles. We conducted an exploratory analysis to determine the efficacy and safety of blinatumomab in 64 patients who had relapsed following alloHSCT prior to enrollment in the phase 2 study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10838791193023
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http://dx.doi.org/10.1016/j.bbmt.2019.04.010DOI Listing
April 2019
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How do nurses use early warning scoring systems to detect and act on patient deterioration to ensure patient safety? A scoping review.

Int J Nurs Stud 2019 Mar 23;94:166-178. Epub 2019 Mar 23.

AVATAR group Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia; HRB Clinical Research Facility Galway, National University of Ireland, Galway, University Hospital Galway, Ireland.

Background: Despite widespread adoption of rapid response systems and the use of various early warning scoring systems, the detection of patient deterioration remains suboptimal, leading to the development of potentially avoidable serious adverse events. Why this occurs has been the focus of many investigations, but the complexities around advancing understanding that leads to effective actions are less evident.

Objective: To better understand medical/surgical nurses use of early warning scoring systems. Read More

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http://dx.doi.org/10.1016/j.ijnurstu.2019.03.012DOI Listing

First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy.

J Allergy Clin Immunol Pract 2019 Apr 16. Epub 2019 Apr 16.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Background: In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine.

Objectives: We sought to examine whether these findings would be applicable in a real-world setting.

Methods: As part of a Canada-wide quality improvement project, academic and community allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.010DOI Listing
April 2019
2 Reads

Reviewing and responding to patient safety incidents in the NHS.

Authors:
John Tingle

Br J Nurs 2019 Apr;28(8):530-531

discusses several recent reports on patient safety incidents in the NHS and the urgent need for action to deal with the problems identified. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.530DOI Listing

Parallelism between risk and perception of risk among caregivers during anesthesia delivery.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3129-3141

Department of Information Engineering, Electronics, and Telecommunications, Sapienza University of Rome, Rome, Italy.

The paper examines the different perceptions of risk associated with anesthesia systems from the viewpoint of the product manufacturer and the caregiver. Only a little research has been done with regard to the impact of perception of risk on patient safety in anesthesia. The role of the manufacturer in mitigating the perception of risk will be central for the work. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17597DOI Listing

Asthma self-management education in persons with work-related asthma - United States, 2012-2014.

J Asthma 2019 Apr 19:1-8. Epub 2019 Apr 19.

a Centers for Disease Control and Prevention (CDC) , National Institute for Occupational Safety and Health , Respiratory Health Division , Morgantown , WV , USA.

Objective: According to the National Asthma Education and Prevention Program (NAEPP), self-management education is an integral component of effective asthma care and should be offered to every patient with asthma. To estimate the proportion of persons with work-related asthma (WRA) who received asthma self-management education.

Methods: A cross-sectional analysis of 2012-2014 Behavioral Risk Factor Surveillance System Asthma Call-back Survey data was conducted among ever-employed adults (≥18 years) with current asthma from 31 states and the District of Columbia. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
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http://dx.doi.org/10.1080/02770903.2019.1594890DOI Listing
April 2019
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Bronchial Thermoplasty in Patients with Severe Uncontrolled Asthma: First Korean Cases.

J Korean Med Sci 2019 Apr 22;34(15):e120. Epub 2019 Apr 22.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Bronchial thermoplasty is a nonpharmacological treatment for severe asthma that delivers thermal energy to the bronchial walls and reduces hypertrophied smooth muscle mass. Previous studies have shown its efficacy and safety, resulting in approval from the Food and Drug Administration in 2010. In Korea, the first bronchial thermoplasty was carried out in 2014; 4 patients have undergone the procedure so far. Read More

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https://jkms.org/DOIx.php?id=10.3346/jkms.2019.34.e120
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http://dx.doi.org/10.3346/jkms.2019.34.e120DOI Listing
April 2019
3 Reads

[Digital OR: better planning and communication].

Authors:
A Meppelink

HNO 2019 Apr 18. Epub 2019 Apr 18.

Brainlab AG, Olof-Palme-Straße 9, 81829, München, Deutschland.

At the center of digital ENT surgery are four primary technological developments: in addition to the potential of a digitalized operating room (OR), these are modern navigation approaches, planning software, and robotics-based assistance systems. In the OR of the future, not only will data enrichment and information integration play a role, but so will the incorporation of high-tech medical devices. Their use and the information they generate are simplified, while at the same time, further clinical data are optimized before, during, and after the surgical procedure. Read More

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http://link.springer.com/10.1007/s00106-019-0664-0
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http://dx.doi.org/10.1007/s00106-019-0664-0DOI Listing
April 2019
1 Read

[Simulation techniques in surgical training programs to become an orthopedic and trauma surgeon : Introduction to the topic].

Authors:
Christian Willy

Unfallchirurg 2019 Apr 18. Epub 2019 Apr 18.

Klinik für Unfallchirurgie, Orthopädie, Septisch-Rekonstruktive Chirurgie, Forschungs- und Behandlungszentrum Rekonstruktion von Defektwunden, Bundeswehrkrankenhaus Berlin, Scharnhorststr. 13, 10115, Berlin, Deutschland.

Numerous professional and societal developments nowadays fundamentally reduce the possibility of mastering all officially prescribed surgical training contents in sufficient quantities and in a target-oriented manner with sufficient operative internal clinical experience from the surgical daily routine. In order to learn key competences, modern simulation technology will have to be integrated into surgical training programs. A meaningful implementation requires a structured procedure for the users, individual clinics or surgical training networks. Read More

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http://dx.doi.org/10.1007/s00113-019-0647-3DOI Listing

Cervical Discogenic Pain Treatment with Percutaneous Jellified Ethanol: Preliminary Experience.

Authors:
Haytham Eloqayli

Biomed Res Int 2019 13;2019:2193436. Epub 2019 Mar 13.

Department of Neurosurgery, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid 22110, Jordan.

Background: Percutaneous DiscoGel® (Gelscom SAS, France), introduced in 2007 as a promising new minimal invasive technique, showed efficacy and safety in lumbar spine surgery, with limited use and scientific reports with regard to the cervical spine. Since the first publication of its use on the cervical spine (2010), less than 100 cases have been published. We introduce an initial experience with this relatively new procedure. Read More

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https://www.hindawi.com/journals/bmri/2019/2193436/
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http://dx.doi.org/10.1155/2019/2193436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436363PMC
March 2019
2 Reads

Explainable machine-learning predictions for the prevention of hypoxaemia during surgery.

Nat Biomed Eng 2018 Oct 10;2(10):749-760. Epub 2018 Oct 10.

Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.

Although anaesthesiologists strive to avoid hypoxemia during surgery, reliably predicting future intraoperative hypoxemia is not currently possible. Here, we report the development and testing of a machine-learning-based system that, in real time during general anaesthesia, predicts the risk of hypoxemia and provides explanations of the risk factors. The system, which was trained on minute-by-minute data from the electronic medical records of over fifty thousand surgeries, improved the performance of anaesthesiologists when providing interpretable hypoxemia risks and contributing factors. Read More

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http://www.nature.com/articles/s41551-018-0304-0
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http://dx.doi.org/10.1038/s41551-018-0304-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467492PMC
October 2018
1 Read

Expert Opinion: Use of sodium glucose co-transporter type-2 inhibitors in South Asian population -The Pakistan perspective.

J Pak Med Assoc 2019 Apr;69(4):555-563

National Institute of Cardiovascular Diseases Karachi, Pakistan.

Sodium-glucose co-transporter type 2 inhibitors (SGLT 2- i)are increasingly being used in the management of type 2 diabetes mellitus (T2DM). With the novel insulinindependent glycosuric action, these agents help to attain glycaemic goals by lowering HbA1c and fasting blood glucose. In addition, these agents improve metabolic control in diabetes and ameliorate comorbidities like obesity and hyper tension. Read More

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April 2019
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Ensuring patient safety through risk management in Pakistan healthcare setting.

Authors:
Ali Yawar Alam

J Pak Med Assoc 2019 Apr;69(4):457-548

Regional Accreditation Coordinator & Director Project Management Office.

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April 2019
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Near-Complete Genome Sequence of a Human Norovirus GII.P7-GII.6 Strain Detected in a Maryland Patient in 2018.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland, USA.

Genomic recombination is a crucial mechanism used to generate genetic variation in human noroviruses. Recombinant variants have been increasingly identified and have contributed to sporadic cases and epidemic outbreaks of acute gastroenteritis globally. We report the near-complete genome of a novel recombinant norovirus GII. Read More

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http://dx.doi.org/10.1128/MRA.00191-19DOI Listing

Pragmatic development of an evidence-based intensive care unit-specific falls risk assessment tool: The Tyndall Bailey Falls Risk Assessment Tool.

Aust Crit Care 2019 Apr 15. Epub 2019 Apr 15.

Royal North Shore Hospital, PO BOX 4007, Royal North Shore LPO, St Leonards, NSW 2065, Australia. Electronic address:

Background: Falls may result in significant patient harm. A recommended strategy to prevent falls is the use of a falls risk assessment tool, but these tools are often specific for older people. Evidence suggests context-specific tools are more effective. Read More

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http://dx.doi.org/10.1016/j.aucc.2019.02.003DOI Listing

The Admission Conference Call: A Novel Approach to Optimizing Pediatric Emergency Department to Admitting Floor Communication.

Jt Comm J Qual Patient Saf 2019 Apr 15. Epub 2019 Apr 15.

Optimizing information sharing at transfer of care between teams is an important target for the improvement of patient safety. Traditional emergency department (ED)-to-floor handoffs do not support a shared mental model between physicians, residents, and nurses. This report describes and evaluates acceptance of a novel process for coordinating physician and nursing handoff calls for patients being admitted to an inpatient floor from a children's hospital ED. Read More

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http://dx.doi.org/10.1016/j.jcjq.2019.02.008DOI Listing

6-Month Outcomes of Tricuspid Valve Reconstruction for Patients With Severe Tricuspid Regurgitation.

J Am Coll Cardiol 2019 Apr;73(15):1905-1915

Department of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.

Background: Severe tricuspid regurgitation (TR) is associated with high morbidity and mortality rates with limited treatment options.

Objectives: The authors report the 6-month safety and performance of a transcatheter tricuspid valve reconstruction system in the treatment of moderate to severe functional TR in 30 patients enrolled in the TRI-REPAIR (TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System) study.

Methods: Between October 2016 and July 2017, 30 patients were enrolled in this single-arm, multicenter, prospective trial. Read More

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http://dx.doi.org/10.1016/j.jacc.2019.01.062DOI Listing

"I'm Trying to Stop Things Before They Happen": Carers' Contributions to Patient Safety in Hospitals.

Qual Health Res 2019 Apr 19:1049732319841021. Epub 2019 Apr 19.

2 Australian Catholic University, Fitzroy, Victoria, Australia.

Patient safety policies increasingly encourage carer (i.e., family or friends) involvement in reducing health care-associated harm in hospital. Read More

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http://dx.doi.org/10.1177/1049732319841021DOI Listing

The Safety and Effectiveness of the Percutaneous Flexor Tenotomy in Healing Neuropathic Apical Toe Ulcers in the Outpatient Setting.

Foot Ankle Spec 2019 Apr 19:1938640019843314. Epub 2019 Apr 19.

Podiatry and Foot Ulcer/Charcot's Specialist Clinic, Austin Health, West Heidelberg, Victoria, Australia.

Percutaneous flexor tenotomy is a minimally invasive procedure that involves cutting one or both flexor digitorum tendons underneath the toe. It is an alternative to open surgical procedures performed in an operating theatre. This project is a prospective case series investigating the utility, effectiveness, and participant satisfaction of the percutaneous flexor tenotomy when performed in the outpatient setting. Read More

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http://dx.doi.org/10.1177/1938640019843314DOI Listing
April 2019
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Long-term safety and efficacy of combined percutaneous LAA and PFO/ASD closure: a single-center experience (LAAC combined PFO/ASD closure).

Expert Rev Med Devices 2019 Apr 19:1-7. Epub 2019 Apr 19.

b Department of Cardiology , Helmut-G.-Walther-Klinikum , Lichtenfels , Germany.

Objectives: To report long-term safety and efficacy of combined percutaneous LAA and PFO/ASD closure.

Methods: A retrospective study of 370 consecutive patients undergoing LAAC procedures using the Watchman (WM) device. Data were compared between 330 cases only with LAAC procedure (Group I) and 25/5 (PFO/ASD) cases with sequential procedures of LAAC and PFO/ASD closure (Group II). Read More

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http://dx.doi.org/10.1080/17434440.2019.1604216DOI Listing

Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing
March 2019
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Successful outcome after Pancreaticodoudenectomy in an elderly cirrhotic patient: A case report.

Int J Surg Case Rep 2019 Apr 10;58:18-20. Epub 2019 Apr 10.

Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan. Electronic address:

Introduction: Cirrhosis is a risk factor for poor outcomes in non-hepatic oncological resections. There are only a handful of cases demonstrating outcomes of pancreaticoduodenectomy (PD) in patients with pancreatic cancer and underlying cirrhosis. Moreover, pushing the limits of PD to elderly cirrhotic patients and demonstrating its safety remains under reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193015
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http://dx.doi.org/10.1016/j.ijscr.2019.03.034DOI Listing
April 2019
2 Reads

Dispatcher-assisted cardiopulmonary resuscitation for paediatric out-of-hospital cardiac arrest: A structured evaluation of communication issues using the SACCIA safe communication typology.

Resuscitation 2019 Apr 15. Epub 2019 Apr 15.

Department of Emergency Medicine, KK Women's & Children's Hospital, 100 Bukit Timah Road, 229899 Singapore. Electronic address:

Aim: To evaluate communication issues during dispatcher-assisted cardiopulmonary resuscitation (DACPR) for paediatric out-of-hospital cardiac arrest in a structured manner to facilitate recommendations for training improvement.

Methods: A retrospective observational study evaluated DACPR communication issues using the SACCIA Safe Communication typology (Sufficiency, Accuracy, Clarity, Contextualization, Interpersonal Adaptation). Telephone recordings of 31 cases were transcribed verbatim and analysed with respect to encoding, decoding and transactional communication issues. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.009DOI Listing

Can a social media campaign increase the use of long-acting reversible contraception? Evidence from a cluster randomized control trial using Facebook.

Contraception 2019 Apr 15. Epub 2019 Apr 15.

Planned Parenthood of Northern New England (PPNNE).

Objective: To test whether an informational campaign carried out on social media increased use of long-acting reversible contraception (LARC).

Study Design: We implement a stratified cluster randomized control trial to identify the effect of an informational campaign carried out using Facebook advertisements designed to increase knowledge of the efficacy, ease of use, and safety of LARC. We randomized all zip codes in a three-state study area to either a control group or a treatment group. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.04.001DOI Listing
April 2019
3 Reads

Development and preliminary testing of an online software system to facilitate assessment of accuracy and consistency in applying the Australasian Triage Scale.

Australas Emerg Care 2018 Nov 16;21(4):150-158. Epub 2018 Oct 16.

Prince of Wales Hospital Emergency Department, Barker Street, Sydney, Australia.

Purpose: The aim of this project was to design and evaluate an online software system to facilitate the assessment of triage decision accuracy and consistency in applying the Australasian Triage Scale.

Background: Triage is a critical component of emergency nursing practice, which affects patient access to emergency care. Accurate and consistent triage decisions are vital to ensuring patient safety, timely access to care and ED operation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2588994X183004
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http://dx.doi.org/10.1016/j.auec.2018.10.001DOI Listing
November 2018
4 Reads

Implementation of guidelines for sepsis management in emergency departments: A systematic review.

Australas Emerg Care 2018 Nov 8;21(4):111-120. Epub 2018 Nov 8.

Deakin University Geelong, School of Nursing and Midwifery and Centre for Quality and Patient Safety Research, Australia; Northern Health, Nursing, Epping, Melbourne, Vic., Australia; Centre for Quality and Patient Safety Research - Eastern Health Partnership Box Hill, Australia.

Introduction: Timely, evidence-based emergency care for sepsis saves lives. The primary aim of this systematic review was to examine the effect of implementation of guidelines for the ED management of sepsis on time to antibiotic administration. Secondary aims were to examine changes in evidence-based sepsis care and patient outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2588994X183005
Publisher Site
http://dx.doi.org/10.1016/j.auec.2018.10.003DOI Listing
November 2018
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Do consumers who identify as Muslim experience culturally safe care (CSC) in the Emergency Department (ED)? A scoping review.

Australas Emerg Care 2018 Aug 1;21(3):93-98. Epub 2018 Sep 1.

School of Nursing, Midwifery and Paramedicine, Faculty of Health, University of Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.

Lack of awareness about cultural and religious values and beliefs of patients presenting to Emergency Departments (ED) can compromise patient care and safety. Muslim Australians represent the fastest growing religious demographic group, with over a 77% growth in the last decade. The changing face of the Australian population requires that Australian health care carefully consider the dominant Western cultural paradigm currently influencing health care delivery. Read More

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http://dx.doi.org/10.1016/j.auec.2018.08.001DOI Listing