134,464 results match your criteria Patient Safety & Quality Healthcare [Journal]


Leakage current from transvenous and subcutaneous implantable cardioverter defibrillators (ICDs): A risk to the rescuer?

Resuscitation 2019 Feb 19. Epub 2019 Feb 19.

NIHR Respiratory BRU, University Hospital Southampton, Southampton, SO16 6YD, UK. Electronic address:

Background: Implantable cardioverter-defibrillators (ICDs) are a well-established therapy for patients at risk of life-threatening ventricular arrhythmias. With rising implant rates, the risk of a rescuer performing chest compressions during discharge is increasing, leading to concerns over rescuer safety from the resultant leakage current. More recently, subcutaneous ICDs (S-ICD) have been developed, which utilise a higher energy and more superficial electrodes compared with transvenous ICDs (T-ICD), raising safety concerns further. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.011DOI Listing
February 2019

Innovation in Chemistry, Manufacturing, and Controls - A Regulatory Perspective From Industry.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

Regulatory Affairs CMC, Amgen Inc., Thousand Oaks, CA, USA.

This review describes the landscape of novel modalities such as cell and gene therapies, viruses, other novel biologics, oligomers, and emerging technologies, including modern analytics. We summarize the regulatory history and recent landmark developments in some major markets and examine specific chemistry, manufacturing, and controls (CMC) challenges, including suggestions for exploration of potential science-based approaches in support of regulatory strategy development from an industry perspective. Additionally, we evaluate the economic factors contributing to patient access to innovation and discuss the impact of regulation. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.007DOI Listing
February 2019

3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

Objectives/hypothesis: To report the clinical safety and efficacy of three-dimensional (3D)-printed, patient-specific, bioresorbable airway splints in a cohort of critically ill children with severe tracheobronchomalacia.

Study Design: Case series.

Methods: From 2012 to 2018, 15 subjects received 29 splints on their trachea, right and/or left mainstem bronchi. Read More

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http://dx.doi.org/10.1002/lary.27863DOI Listing
February 2019

Brief (<4 hour) sleep episodes are insufficient for restoring performance in first-year resident physicians working overnight extended-duration work shifts.

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, USA.

Study Objectives: The Accreditation Council for Graduate Medical Education (ACGME) recently reinstated extended-duration (24-28 hour) work shifts (EDWS) for postgraduate year 1 (PGY-1) resident physicians. This study examined the relationship between overnight sleep duration during EDWS and subsequent 'post-call' performance in PGY-1 resident physicians.

Methods: Thirty-four PGY-1 resident physicians (23 males; 24-32 years) were studied between 2002-2004 during three-week Q3 'on-call' rotation schedules in the Medical and Cardiac Intensive Care Units at Brigham and Women's Hospital in Boston. Read More

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http://dx.doi.org/10.1093/sleep/zsz041DOI Listing
February 2019

Preventing Hypoglycemia Following Treatment of Hyperkalemia in Hospitalized Patients.

J Hosp Med 2019 Feb 20;14:E1-E4. Epub 2019 Feb 20.

King's Insulin Safety Group, King's College Hospital NHS Foundation Trust, London, United Kingdom.

Hypoglycemia is a serious complication following treatment of hyperkalemia with intravenous insulin. The aims of this study were to determine the incidence of hypoglycemia (≤3.9 mmol/l, 70 mg/dL) and severe hypoglycemia (<3. Read More

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http://dx.doi.org/10.12788/jhm.3145DOI Listing
February 2019

National Survey of Hospitalists' Experiences with Incidental Pulmonary Nodules.

J Hosp Med 2019 Feb 20;14:E1-E4. Epub 2019 Feb 20.

University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Incidental pulmonary nodules (IPNs) are common and often require follow-up. The Fleischner Society guidelines were created to support IPN management. We developed a 14-item survey to examine hospitalists' exposure to and management of IPNs. Read More

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http://dx.doi.org/10.12788/jhm.3115DOI Listing
February 2019

Definitive urine drug testing in office-based opioid treatment: a literature review.

Crit Rev Toxicol 2019 Feb 22:1-24. Epub 2019 Feb 22.

b PLLC , Ideal Option , Kennewick , WA , USA.

Individuals who receive buprenorphine treatment for opioid use disorder in office-based settings may be at risk for, or have a history of, polysubstance use. Urine drug testing is an important clinical tool for monitoring medication adherence and patient stability; and screening for illicit drug use and dangerous drug-drug interactions. This article is intended to educate practitioners in office-based opioid treatment settings on selecting appropriate substances for a definitive drug testing panel that are known to be used concurrently, sequentially, or in combination with buprenorphine for opioid use disorder. Read More

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http://dx.doi.org/10.1080/10408444.2018.1553935DOI Listing
February 2019

Safety and efficiency of a common and simplified protocol for pacemaker and defibrillator surveillance based on remote monitoring only: a long-term randomized trial (RM-ALONE).

Eur Heart J 2019 Feb 21. Epub 2019 Feb 21.

Hospital Vall d`Hebron, Passeig de la Vall d'Hebron, Barcelona, Spain.

Aims: This trial aimed to evaluate the safety and efficiency of a common and simplified protocol for the surveillance of cardiac implantable electronic devices based on remote monitoring (RM) in patients with pacemakers (PMs) and implantable cardiac defibrillators (ICDs) for at least 24 months.

Methods And Results: The RM-ALONE is a multicentre prospective trial that randomly assigned 445 patients in two groups, both followed by RM: the home monitoring-only (HMo) based on RM + remote interrogations (RIs) every 6 months and the HM + IO that adds in-office evaluations every 6 months to RM. Four hundred and forty-five patients were enrolled in the study, 294 PMs and 151 ICDs recipients. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz067DOI Listing
February 2019

Efficacy, long-term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan.

Neurogastroenterol Motil 2019 Feb 21:e13571. Epub 2019 Feb 21.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Background: In two phase 3 trials, elobixibat, a locally acting ileal bile acid transporter inhibitor, resolved constipation and was well tolerated in Japanese patients with chronic constipation. We analyzed the efficacy, safety, and impact on quality of life (QOL) of elobixibat in patients with symptomatically more severe constipation in the two phase 3 trials.

Methods: This post hoc analysis of elobixibat treatment outcomes included data from a 2-week, randomized, placebo-controlled, phase 3 trial (10 mg/d), and a 52-week, open-label trial (5-15 mg/d) in subgroups with severe constipation defined as ≤2 spontaneous bowel movements (SBMs) and ≤3 Bristol Stool Form Scale score during the second week of the 2-week run-in period. Read More

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http://dx.doi.org/10.1111/nmo.13571DOI Listing
February 2019

Evaluating Horizontal Violence and Bullying in the Nursing Workforce of an Oncology Academic Medical Center.

J Nurs Manag 2019 Feb 21. Epub 2019 Feb 21.

University of Miami, Sylvester Comprehensive Cancer Center.

Aim: To evaluate horizontal violence and bullying in the nursing workforce of an oncology inpatient and outpatient academic center, and to test the Horizontal Violence Scale in an outpatient setting.

Background: Horizontal violence (HV) and bullying in the workplace are dysfunctional behaviors that can affect nursing staff and patient care. The impact of bullying and HV is multilevel, affecting patient safety and satisfaction, nursing retention, and employee satisfaction, while creating poor patient outcomes. Read More

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http://dx.doi.org/10.1111/jonm.12763DOI Listing
February 2019

Romiplostim in adult patients with newly diagnosed or persistent immune thrombocytopenia (ITP) for up to 1 year and in those with chronic ITP for more than 1 year: a subgroup analysis of integrated data from completed romiplostim studies.

Br J Haematol 2019 Feb 21. Epub 2019 Feb 21.

Amgen Inc., Thousand Oaks, CA, USA.

The thrombopoietin receptor agonist romiplostim is approved for second-line use in chronic immune thrombocytopenia (ITP), but its effects in patients with ITP for ≤1 year are not well characterized. This analysis of pooled data from 9 studies included patients with ITP for ≤1 year (n = 311) or >1 year (n = 726) who failed first-line treatments and received romiplostim, placebo or standard of care. In subgroup analysis by ITP duration, patient incidences for platelet response at ≥75% of measurements were higher for romiplostim [ITP ≤1 year: 74% (204/277); ITP >1 year: 71% (450/634)] than for placebo/standard of care [ITP ≤1 year: 18% (6/34); ITP >1 year: 9% (8/92)]. Read More

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http://doi.wiley.com/10.1111/bjh.15803
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http://dx.doi.org/10.1111/bjh.15803DOI Listing
February 2019
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The Health Status of Veteran Employees Compared to Civilian Employees in Veterans Health Administration.

Mil Med 2019 Feb 22. Epub 2019 Feb 22.

Boston VA Health Care System, Center for Healthcare Organization and Implementation Research, 150 South Huntington Avenue, Jamaica Plain, MA.

Introduction: Veterans Health Administration (VHA) is undergoing changes in the practice of health care focusing on approaches that prioritize veteran well-being. Given transformation efforts, opportunities exist to enhance the health and well-being of patients and employees alike - a significant proportion of whom are veterans. To date, differences in health status between veteran and civilian employees within VHA have not been examined. Read More

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http://dx.doi.org/10.1093/milmed/usy410DOI Listing
February 2019

Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations.

Can J Gastroenterol Hepatol 2019 8;2019:4383269. Epub 2019 Jan 8.

The Department of Gastroenterology at Staten Island University Hospital, Northwell Health, USA.

The introduction of Direct Oral Anticoagulants (DOACs) to the pharmaceutical market provided patients and clinicians with novel convenient and safe options of anticoagulation. The use of this class of medications is currently limited to venous thromboembolic therapy and prophylaxis, in addition to stroke prophylaxis in patients with nonvalvular atrial fibrillation. Despite their altered hemostasis, patients with cirrhosis are thought to be in a procoagulant state and thus prone to thrombus formation. Read More

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http://dx.doi.org/10.1155/2019/4383269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354142PMC
January 2019

Implementation of infection prevention and control in acute care hospitals in Mainland China - a systematic review.

Antimicrob Resist Infect Control 2019 11;8:32. Epub 2019 Feb 11.

Infection Control Program and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211 Geneva 14, Switzerland.

Background: Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) affect patients in acute-care hospitals worldwide. No systematic review has been published on adoption and implementation of the infection prevention and control (IPC) key components. The objective of this systematic review was to assess adoption and implementation of the three areas issued by the "National Health Commission of the People's Republic of China" in acute-care hospitals in Mainland China, and to compare the findings with the key and core components on effective IPC, issued by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1186/s13756-019-0481-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371478PMC
February 2019

Safety and feasibility of above cuff vocalisation for ventilator-dependant patients with tracheostomies.

J Intensive Care Soc 2019 Feb 28;20(1):59-65. Epub 2018 Mar 28.

Acute Intensive Care Unit, University Hospital South Manchester, Manchester, UK.

Introduction: Temporary tracheostomy is commonly used in patients admitted to intensive care units. Cuffed tubes prevent laryngeal airflow, preventing vocalisation. Sub-glottic suction tubes such as the 'Blue Line Ultra ' are used primarily to remove sub-glottic secretions, but retrograde gas flows via the suction port can facilitate above cuff vocalisation. Read More

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http://dx.doi.org/10.1177/1751143718767055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376581PMC
February 2019

Promising Combination Therapy with Bevacizumab and Erlotinib in an EGFR-Mutated NSCLC Patient with MET Amplification Who Showed Intrinsic Resistance to Initial EGFR-TKI Therapy.

Case Rep Oncol 2019 Jan-Apr;12(1):91-97. Epub 2019 Jan 21.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

In lung cancer, several potential mechanisms of intrinsic and acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been explored, including mesenchymal-epithelial transition factor (MET) signaling pathway activation. On the other hand, vascular endothelial growth factor (VEGF) production of EGFR-mutated lung cancer cells is stimulated by predominantly activated MET signaling pathway. Therefore, the inhibition of VEGF axis as the downstream target of MET signaling pathway seems promising. Read More

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http://dx.doi.org/10.1159/000493088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381877PMC
January 2019

Left main bronchus as a guide for individualized transseptal puncture using a conventional fluoroscopic approach in cryoballoon ablation of atrial fibrillation.

Anatol J Cardiol 2019 Dec 31. Epub 2019 Dec 31.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University (Air Force Medical University); Xi'an-China.

Objective: Although imaging modalities, such as transesophageal and intracardiac echocardiography, have helped to improve the safety of atrial transseptal puncture (TSP), fluoroscopy is still traditionally and widely used in TSP. The aim of the present study was to evaluate an individual knack for TSP during cryoballoon ablation of atrial fibrillation (AF) under fluoroscopy.

Methods: Through the prospective study of 72 cases of patients with paroxysmal or persistent AF admitted for cryoablation in our center, 46 cases using a puncture site toward the bifurcation of the left main bronchus (LMB group) and 26 cases using an anterior-inferior puncture site (AI group) were included in the study. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2018.08566DOI Listing
December 2019

Endovascular Treatment for Low-Grade (Spetzler-Martin I-II) Brain Arteriovenous Malformations.

AJNR Am J Neuroradiol 2019 Feb 21. Epub 2019 Feb 21.

From the Department of Interventional Neuroradiology (H.B., R.B., R.F., S.S., G.C., J.-P.D, H.R., S.E., M.M., P.S., M.P.).

Background And Purpose: Surgical resection is usually considered as the first-line curative strategy for low-grade (Spetzler-Martin grade I-II) brain arteriovenous malformations because it has a high cure rate and low complications. The role of endovascular treatment remains to be clarified in this indication, especially after A Randomized Trial of Unruptured Brain Arteriovenous Malformations. Our objective was to assess the safety and efficacy of first-line endovascular treatment in low-grade brain arteriovenous malformation management at our institution. Read More

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http://dx.doi.org/10.3174/ajnr.A5988DOI Listing
February 2019

Harmonization of Pharmacovigilance Regulation in Brazil: Opportunities to Improve Risk Communication.

Clin Ther 2019 Feb 18. Epub 2019 Feb 18.

Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil. Electronic address:

Brazilian pharmacovigilance regulations involve 3 spheres: health services, Marketing Authorization Holders (MAHs), and sanitary agency. Drug tolerability began to be effectively assessed in Brazil after the founding of the National Agency of Sanitary Surveillance, which developed the Sentinel Network Project. The objective of the Sentinel Network Project is to increase the adverse drug reaction (ADR) reporting rate by health care professionals in the hospital setting. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.01.013DOI Listing
February 2019

Impact of Discontinuation of Antithrombotic Therapy Following Closure of Patent Foramen Ovale in Patients With Cryptogenic Embolism.

Am J Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada; Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada. Electronic address:

No data exist on the optimal duration of antithrombotic therapy (AT) following patent foramen ovale (PFO) closure. We sought to assess the safety of AT discontinuation following PFO closure in patients with a cryptogenic ischemic event. A total of 453 consecutive patients (mean age: 48 ± 13 years, men: 51%) who underwent PFO closure due to a cryptogenic ischemic event were included. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.043DOI Listing
February 2019

Implementation of a Pilot Pharmacist Testosterone Therapy Management Service.

J Pharm Pract 2019 Feb 21:897190019830251. Epub 2019 Feb 21.

1 William S. Middleton Memorial Veteran Affairs Hospital, Madison, WI, USA.

Background:: Recent literature findings suggest that opportunities exist to optimize testosterone replacement therapy management.

Objective:: To evaluate the impact of a pilot clinical pharmacist testosterone therapy management service in a Veterans Affairs primary care setting.

Methods:: A 6-month, single-clinic, prospective cohort quality improvement project included male patients with an active prescription for testosterone. Read More

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http://dx.doi.org/10.1177/0897190019830251DOI Listing
February 2019

Biosimilars for inflammatory bowel disease: how can healthcare professionals help address patients' concerns?

Expert Rev Gastroenterol Hepatol 2019 Feb 17;13(2):143-155. Epub 2019 Jan 17.

a Department of Gastroenterology and Hepatology , Amsterdam UMC , Amsterdam , The Netherlands.

Introduction: The patent expiration of some biologics used in chronic conditions such as inflammatory bowel disease (IBD) has led to the development of biosimilar monoclonal antibodies. The tailored regulatory approval route for biosimilar development ensures that approved biosimilars show similarity to their originators in terms of efficacy and safety, and avoids unnecessary repetition of clinical trials carried out with the originator product. However, some patients may still have concerns about using biosimilars and it is the responsibility of healthcare professionals (HCPs) to alleviate these concerns. Read More

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http://dx.doi.org/10.1080/17474124.2019.1553617DOI Listing
February 2019

Safety and tolerability of linaclotide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: pooled Phase 3 analysis.

Expert Rev Gastroenterol Hepatol 2019 Feb 6:1-10. Epub 2019 Feb 6.

a Division of Gastroenterology, Department of Medicine , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

Background: Linaclotide is approved for treating irritable bowel syndrome with constipation (IBS-C; 290 µg QD) and chronic idiopathic constipation (CIC; 145 µg or 72 µg QD). These analyses aimed to assess linaclotide safety in a large, pooled Phase 3 population.

Methods: In six randomized controlled trials (RCTs), patients received linaclotide (72 µg, 145 µg, 290 µg) or placebo daily for 12-26 weeks; in two long-term safety (LTS) studies, patients received open-label linaclotide for ≤78 additional weeks. Read More

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http://dx.doi.org/10.1080/17474124.2019.1575203DOI Listing
February 2019

A Pilot Study of Vaccine Therapy with Multiple Glioma Oncoantigen/Glioma Angiogenesis-Associated Antigen Peptides for Patients with Recurrent/Progressive High-Grade Glioma.

J Clin Med 2019 Feb 20;8(2). Epub 2019 Feb 20.

Department of Neurosurgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8587, Japan.

High-grade gliomas (HGGs) carry a dismal prognosis despite current treatments. We previously confirmed the safety and immunogenicity of a vaccine treatment targeting tumor angiogenesis with synthetic peptides, for vascular endothelial growth factor receptor (VEGFR) epitopes in recurrent HGG patients. In this study, we evaluated a novel vaccine therapy targeting not only tumor vasculature but also tumor cells, using multiple glioma oncoantigen (GOA)/glioma angiogenesis-associated antigen (GAAA) peptides in HLA-A2402+ recurrent/progressive HGG patients. Read More

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http://dx.doi.org/10.3390/jcm8020263DOI Listing
February 2019

The Microbiological Characteristics of Carbapenem-Resistant Carrying the Gene.

J Clin Med 2019 Feb 19;8(2). Epub 2019 Feb 19.

Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan.

Objectives: This study aims to assess the prevalence of the gene among carbapenem-resistant (CRE) isolated from clinical specimens and to further investigate the clinical significance and microbiological characteristics of CRE carrying the gene.

Methods: Four hundred and twenty-three CRE isolates were screened for the presence of the gene. After identification, their clinical significance, antibiotic susceptibility, and antibiotic resistance mechanisms including the ESBL gene, carbapenemase gene, outer membrane protein (OMP), and plasmid sequencing were assessed. Read More

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http://dx.doi.org/10.3390/jcm8020261DOI Listing
February 2019

Inverse association between caffeine intake and depressive symptoms in US adults: data from National Health and Nutrition Examination Survey (NHANES) 2005-2006.

Psychiatry Res 2019 Jan 23;271:732-739. Epub 2018 Nov 23.

Department of Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Safety Promotions and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

The objective of this study was to examine the association between caffeine consumption and depressive symptoms. We used data from the 2005-06 National Health and Nutritional Examination Surveys (NHANES). A total of 4737 individuals aged ≥ 18 years who answered the caffeine intake and PHQ-9 questionnaires were selected for this study. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.11.004DOI Listing
January 2019

Post Option B+ implementation programme in Nigeria: Determinants of adherence of antiretroviral therapy among pregnant women with HIV.

Int J Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

Department of Nursing, School of Health Sciences, The University of Melbourne, Melbourne, Australia.

Objective: Nigeria has the highest rate of mother to child transmission of HIV (MTCT) in the world. By 2015, all Global Plan priority countries, except Nigeria, had adopted the Option B+ programme.Nigeria finally adopted Option B+ in 2016 with full implementation reported in 2017. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.014DOI Listing
February 2019

Lessons Learned from First in Human Low-Field MRI-Guided Radiation Therapy of the Heart in the Presence of an Implantable Cardiac Defibrillator.

Pract Radiat Oncol 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO.

Magnetic resonance imaging guided radiation therapy (MR-IGRT) is reported for the first time in a patient with an implantable cardioverter defibrillator (ICD) and a cardiac fibroma in the left ventricle. Stereotactic body radiation therapy (SBRT) was delivered in five fractions at a dose of 700 cGy/fraction using a 0.35 T MRI-Linac with real-time tumor tracking and beam gating. Read More

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http://dx.doi.org/10.1016/j.prro.2019.02.003DOI Listing
February 2019

Nurse understaffing is associated with adverse events in postanesthesia care unit patients.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece.

Aims And Objectives: This study investigated the associations between nurse staffing and the incidence and severity of hypoxemia, arterial hypotension and bradycardia of postoperative patients during their postanesthesia care unit stay.

Background: Nurse understaffing has been associated with adverse patient outcomes in a variety of hospital settings. In the postanesthesia care unit, nursing shortage is common and can be related to compromised prevention, detection and treatment of adverse events. Read More

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http://dx.doi.org/10.1111/jocn.14819DOI Listing
February 2019

Ra-dichloride therapy of bone metastasis: optimization of SPECT images for quantification.

EJNMMI Res 2019 Feb 21;9(1):20. Epub 2019 Feb 21.

Internal Dose Assessment Laboratory, Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, France.

Background: Ra imaging is crucial to evaluate the successfulness of the therapy of bone metastasis of castration-resistant prostate cancer (CRPC). The goals of this study were to establish a quantitative tomographic Ra imaging protocol with clinically achievable conditions, as well as to investigate its usefulness and limitations. We performed several experiments using the Infinia Hawkeye 4 gamma camera (GE) and physical phantoms in order to assess the optimal image acquisition and reconstruction parameters, such as the windows setting, as well as the iteration number and filter of the reconstruction algorithm. Read More

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http://dx.doi.org/10.1186/s13550-019-0488-7DOI Listing
February 2019

Complementary and Integrative Medicine for Episodic Migraine: an Update of Evidence from the Last 3 Years.

Curr Pain Headache Rep 2019 Feb 21;23(2):10. Epub 2019 Feb 21.

Department of Neurology, Wake Forest Baptist Health, Winston-Salem, NC, USA.

Purpose Of Review: The purpose of this review is to evaluate evidence from the last 3 years on complementary and integrative medicine treatment options for episodic migraine. Using Pubmed, Embase, and Cochrane databases, research published from 2015-2018 evaluating the modalities of mind/body therapies, supplements, and manual therapies for treatment of migraine were assessed.

Recent Findings: Although many studies had major methodological challenges that limit interpretation, several studies reported decreased headache frequency, improved quality of life, or less affective responses to pain. Read More

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http://dx.doi.org/10.1007/s11916-019-0750-8DOI Listing
February 2019

Diagnostic Accuracy in Fit-for-Purpose PD-L1 Testing.

Appl Immunohistochem Mol Morphol 2019 Feb 15. Epub 2019 Feb 15.

Canadian Immunohistochemistry Quality Control.

PD-L1 testing by immunohistochemistry (IHC) has presented significant challenges not only for clinical laboratories, but also for external quality assurance (EQA) entities that provide proficiency testing (PT) for clinical laboratories. Canadian Immunohistochemistry Quality Control (CIQC) has used educational runs to explore approaches to sample design and analysis of results that would enhance patient safety. As PT for predictive biomarkers requires modeling at every level (design of the run, assessment of the run, and reporting of "pass" or "fail") based on "fit-for-purpose" principles, CIQC has applied those principles to PD-L1 PT runs. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000734DOI Listing
February 2019

Arthroscopic Labral Treatment in Adolescents: Clinical Outcomes With Minimum 5-Year Follow-up.

Am J Sports Med 2019 Feb 21:363546519825627. Epub 2019 Feb 21.

American Hip Institute, Westmont, Illinois, USA.

Background:: The success of hip arthroscopy has led to increased application in younger populations. However, hip arthroscopy remains a challenging procedure, and its safety and efficacy in the adolescent population have been controversial. Most existing literature on outcomes in such patients contains only short-term follow-up, and a paucity of evidence is available regarding long-term outcomes in adolescents. Read More

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http://dx.doi.org/10.1177/0363546519825627DOI Listing
February 2019

Using a Delphi Survey to Develop Clinical Nursing Research Priorities Among Nursing Management.

J Nurs Adm 2019 Mar;49(3):156-162

Author Affiliations: Associate Research Scientist (Dr Sun), Columbia University School of Nursing, New York; (Dr Sun), and Director of Surgical Nursing (Dr Prufeta), New York-Presbyterian.

Objective: The aim of this study was to identify clinical nursing research priorities among nurse managers (NMs).

Background: Determining research priorities is the 1st step toward building a solid evidence base for clinical practice. NMs are well poised to identify research priorities, and yet, a literature review revealed a dearth of research priorities as determined by clinical NMs. Read More

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http://dx.doi.org/10.1097/NNA.0000000000000730DOI Listing

Lip and Perioral Enhancement With Hyaluronic Acid Dermal Fillers in Individuals With Skin of Color.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

Allergan plc, Irvine, California.

Background: Individuals with skin of color are underrepresented in studies of lip and perioral enhancement.

Objective: To examine the effectiveness and safety of hyaluronic acid (HA) dermal filler treatment for lip and perioral enhancement in subjects with skin of color.

Methods: Data were pooled from subjects with Fitzpatrick skin phototypes IV, V, or VI in 2 pivotal studies of HA dermal fillers. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001842DOI Listing
February 2019

Delayed-Onset Nodules to Differentially Crosslinked Hyaluronic Acids: Comparative Incidence and Risk Assessment.

Dermatol Surg 2019 Feb 14. Epub 2019 Feb 14.

SkinCare Physicians, Chestnut Hill, Massachusetts.

Background: Robust and long-term data on true incidence of delayed-onset nodules and immune tolerance of hyaluronic acid (HA) fillers are lacking.

Objective: To characterize the incidence of delayed nodules in Vycross (VYC) HA fillers compared with previously reported FDA and non-FDA data of all HA fillers.

Methods And Materials: The incidence of delayed nodules in all patients who had received VYC fillers in a 12-month period was assessed through a retrospective chart review. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001814DOI Listing
February 2019

Pediatric Sexual Abuse: An Interprofessional Approach to Optimizing Emergency Care.

J Forensic Nurs 2019 Jan/Mar;15(1):18-25

Emergency Services, Novant Health Presbyterian Medical Center.

Introduction: Pediatric sexual abuse can lead to devastating lifelong consequences for the child, their caregivers, and society at large. To achieve the goal of optimizing patient outcomes, strategies to enhance teamwork, education, and mentorship are essential. The ultimate goal of child safety and protection through an evidence-based approach will only be attained when interprofessional alignment of expertise and resources is implemented. Read More

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http://dx.doi.org/10.1097/JFN.0000000000000232DOI Listing
February 2019

Safety and Efficacy of Combined Peptide Receptor Radionuclide Therapy and Liver Selective Internal Radiation Therapy in a Patient With Metastatic Neuroendocrine Tumor.

Clin Nucl Med 2019 Feb 15. Epub 2019 Feb 15.

Gastrointestinal Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Nuclear medicine treatments of well-differentiated neuroendocrine tumors (NETs) are gaining increasing acceptance among clinicians. Peptide receptor radionuclide therapy (PRRT) is an effective systemic treatment, providing a significant survival benefit and improving patients' quality of life. Locoregional selective internal radiation therapy (SIRT) is a safe and effective treatment for unresectable NET liver metastases, providing good local tumor control and symptomatic relief. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002480DOI Listing
February 2019

Reverse Distraction for Treatment of Hydrocephalic Macrocephaly in Late Childhood.

J Craniofac Surg 2019 Feb 14. Epub 2019 Feb 14.

Division of Pediatric Plastic and Craniofacial Surgery and Division of Neurosurgery, Children's Mercy Hospital, Kansas City, MO.

Macrocephaly diminishes quality of life for children whose head size inhibits independent mobility and appropriate interaction with caregivers. Cranial reduction is a method of addressing these issues, historically with a high morbidity due most commonly to bleeding and shunt complications. The authors present a 9-year-old girl with holoprosencephaly and severe macrocephaly from progressive hydrocephalus who underwent cranial reduction via reverse distraction osteogenesis, a method to slowly reduce the skull volume. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005072DOI Listing
February 2019

How Transparency Efforts Helped One System's Financial Turnaround.

Authors:
Stephen A Purves

Front Health Serv Manage 2019 ;35(3):3-13

Stephen A. Purves, FACHE, is president and CEO of Maricopa Integrated Health System in Phoenix, Arizona.

Healthcare consumerism, costs, and price transparency are garnering unprecedented attention from hospitals and health systems in the United States. To many observers of the US healthcare delivery system, the inability to provide accurate pricing information and the variability in prices for comparable services are utter failures of the administrative infrastructure that supports patient care processes.Price transparency and the affordability of healthcare have also become top concerns for professional and trade organizations, which are devoting significant resources to assist member institutions in facing these issues. Read More

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http://dx.doi.org/10.1097/HAP.0000000000000051DOI Listing
January 2019

The case of Patient Safety Indicator 12 (PSI12): use of administrative data to estimate the incidence of "Postoperative Pulmonary Embolism or Deep Vein Thrombosis". A pilot study in a General Hospital.

Clin Ter 2019 Jan-Feb;170(1):e27-e35

Department of Public Health and Infectious Diseases, "Sapienza University of Rome".

Introduction: The AHRQ Quality Indicators (QIs) were created in order to both identify the performance and to track the improvement of patient safety. Patient Safety Indicator 12 (PSI12) is relative to the risk of Post Operatory Pulmonary Embolism or Deep Venous Thrombosis (PO DVT/PE). This pilot study has three main objectives. Read More

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http://dx.doi.org/10.7417/CT.2019.2104DOI Listing
February 2019

Window Period Prophylaxis for Children Exposed to Tuberculosis, Houston, Texas, USA, 2007-2017.

Emerg Infect Dis 2019 Mar;25(3):523-528

In this retrospective study, we assessed the safety of window period prophylaxis and proportion of tuberculin skin test (TST) conversions in children <5 years of age who were exposed to an adult with tuberculosis disease during 2007-2017. Children included in this study had unremarkable examination and chest radiograph findings and negative test results for TB infection. In total, 752 children (41% cohabitating with the index patient) received prophylaxis during the window period, usually directly observed therapy with isoniazid. Read More

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http://dx.doi.org/10.3201/eid2503.181596DOI Listing

Trans-iris fixation of dislocated in-the-bag intraocular lenses.

Eur J Ophthalmol 2019 Feb 21:1120672119831161. Epub 2019 Feb 21.

Ophthalmic Research Center and Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose:: The aim of this article is to describe the safety and efficacy of trans-iris suture fixation for the management of late dislocation of in-the-capsular-bag intraocular lenses following uncomplicated cataract surgery.

Patients And Methods:: Eleven eyes of 11 patients with late in-the-capsular-bag intraocular lens dislocation following uneventful phacoemulsification cataract surgery were recruited in the study. The dislocated intraocular lens-capsular bag complex was sutured to the iris at two points 180° apart using 9-0 polypropylene sutures on long needles. Read More

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http://dx.doi.org/10.1177/1120672119831161DOI Listing
February 2019

Antibiotics for Prevention of Postoperative Infection From Mohs on the Leg: A Survey of the American College of Mohs Surgery.

J Cutan Med Surg 2019 Jan/Feb;23(1):121-122

1 Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1177/1203475418800944DOI Listing
February 2019

Exploring hospital patient sitters' fall prevention task readiness: A cross-sectional survey.

J Eval Clin Pract 2019 Feb 20. Epub 2019 Feb 20.

School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Western Australia, Australia.

Rationale, Aims, And Objectives: Patient sitters provide one-to-one care for hospital patients at high risk of falls. The study aimed to explore patient sitters' task readiness to assist in fall prevention on hospital wards.

Method: We conducted a cross-sectional survey. Read More

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http://dx.doi.org/10.1111/jep.13114DOI Listing
February 2019

Effects of standardized hydro-alcoholic extract of leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial.

Avicenna J Phytomed 2019 Jan-Feb;9(1):44-53

Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.

Objective: To study the blood pressure, lipid and glycemic effects and safety of leaf in the hypertensive hyperlipidemic type 2 diabetic patients.

Materials And Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups. Read More

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February 2019

Stereotactic ablative body radiation for oligometastatic and oligoprogressive disease.

Transl Lung Cancer Res 2019 Feb;8(1):97-106

Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Stage IV non-small cell lung cancer (NSCLC) exists on a spectrum, with a subset of patients presenting with oligometastatic disease involving only a limited number of distant sites. For these patients, local consolidative therapy (LCT) has been demonstrated to improve outcomes through ablation or cytoreduction of metastatic disease, as shown in an increasing number of randomized controlled trials. In particular, stereotactic ablative body radiation (SABR) has emerged as a feasible treatment modality for elimination of oligometastatic sites. Read More

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http://dx.doi.org/10.21037/tlcr.2018.09.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351406PMC
February 2019

Empiric Radiotherapy for Lung Cancer Collaborative Group multi-institutional evidence-based guidelines for the use of empiric stereotactic body radiation therapy for non-small cell lung cancer without pathologic confirmation.

Transl Lung Cancer Res 2019 Feb;8(1):5-14

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

The standard of care for managing early stage non-small cell lung cancer (NSCLC) is definitive surgical resection. Stereotactic body radiation therapy (SBRT) has become the standard treatment for patient who are medically inoperable, and it is increasingly being considered as an option in operable patients. With the growing use of screening thoracic CT scans for patients with a history of heavy smoking, as well as improved imaging capabilities, the discovery of small lung nodes has become a common dilemma. Read More

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http://dx.doi.org/10.21037/tlcr.2018.12.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351405PMC
February 2019

Complete response to pembrolizumab in a patient with metastatic colon cancer with microsatellite instability and a history of Guillain-Barre syndrome.

J Gastrointest Oncol 2019 Feb;10(1):161-165

Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA, USA.

Currently, clinical trials with programmed death-1 (PD-1) inhibitors exclude patients with preexisting autoimmune disorders such as Guillain-Barre syndrome (GBS). Therefore, the scientific literature has limited information about the efficacy and safety of PD-1 inhibitors in cancer patients with autoimmune disorders. Immune checkpoint inhibitors can exacerbate preexisting autoimmune disorders and can induce severe immune-related adverse events. Read More

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http://dx.doi.org/10.21037/jgo.2018.09.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351297PMC
February 2019