1,762,422 results match your criteria Pathophysiology of Haemostasis and Thrombosis[Journal]


Targeted and untargeted LC-MS polyphenolic profiling and chemometric analysis of propolis from different regions of Croatia.

J Pharm Biomed Anal 2018 Dec 4;165:162-172. Epub 2018 Dec 4.

University of Rijeka, Department of Biotechnology, Centre for high-throughput technologies, Radmile Matejčić 2, 51000 Rijeka, Croatia. Electronic address:

Propolis is a complex biological matrix consisting mostly of plant resins and waxes, and in a small proportion of the herbal secondary metabolites, phenols. Phenols are components that are responsible for biological activities of propolis, however, their qualitative and quantitative composition is strongly influenced by climate and vegetation. Although studies on profiling of propolis samples from different countries have been carried out for some time propolis from Croatia is still not characterized till now. Read More

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December 2018

Ventilator-associated pneumonia: The central role of transcolonization.

J Crit Care 2018 Dec 6;50:155-161. Epub 2018 Dec 6.

Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:

Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More

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December 2018

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

Int Immunopharmacol 2018 Dec 10;67:138-144. Epub 2018 Dec 10.

Institute of Clinical Pharmacy and Pharmacology, Jining First People's Hospital, Jining Medical University, Jining, China. Electronic address:

Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the present study aims to explore whether the anti-depressive effect of curcumin is connected to its anti-inflammatory features. Read More

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December 2018

Synaptic potentiation and rapid antidepressant response to ketamine in treatment-resistant major depression: A replication study.

Psychiatry Res Neuroimaging 2018 Sep 12;283:64-66. Epub 2018 Sep 12.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Preclinical and clinical evidence has demonstrated that ketamine has rapid antidepressant effects. Studies using pre-treatment with an AMPA inhibitor suggest that enhancing AMPA throughput is crucial to ketamine's effects, including increases in both basal and evoked gamma power. This study sought to replicate previous findings of increased gamma response to a somatosensory stimulus at 230 min and Day 1 in ketamine responders versus non-responders in 31 depressed subjects and 25 healthy controls. Read More

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September 2018
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Expressions of homeobox, collagen and estrogen genes in women with uterine prolapse.

Eur J Obstet Gynecol Reprod Biol 2018 Nov 29;233:26-29. Epub 2018 Nov 29.

Ankara University, School of Medicine, Department of Biostatistics, Ankara, Turkey.

Objective: Genetic contribution is thought to be involved in the pathophysiology of pelvic organ prolapse (POP). We aimed to study the gene expression profiles of the genes HomeoboxA11 (HOXA11), HomeoboxA13 (HOXA13), Collagen Type I (COL1A), Collagen Type III (COL3A), estrogen receptor genes (ESR1 and ESR2) of round (RL) and uterosacral ligaments (USL) in postmenopausal women with uterine prolapse.

Study Design: Gene expressions of 32 postmenopausal women with prolapse were analysed according to gene expressions of 8 postmenopausal women without prolapse. Read More

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November 2018

Targeting STATs in neuroinflammation: the Road Less Traveled!

Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

JAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. Dysregulation of this pathway is involved in the onset of autoimmune, haematological, oncological, metabolic and neurological diseases. Over the last few years, the research of anti-neuroinflammatory agents has gained considerable attention. Read More

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December 2018
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Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice.

Brain Behav Immun 2018 Dec 11. Epub 2018 Dec 11.

Departament de Biologia Cel·lular, Fisiologia i Immunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, Catalonia, 08193, Spain. Electronic address:

Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions by signaling through six known G-protein-coupled receptors (LPA-LPA). In the central nervous system (CNS), LPA mediates a wide range of effects, including neural progenitor cell physiology, astrocyte and microglia activation, neuronal cell death, axonal retraction, and contributions to pain, schizophrenia and hydrocephalus. We recently reported that LPA-LPA signaling mediates functional deficits and myelin loss after spinal cord injury (SCI). Read More

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December 2018

Geraniol protects against lipopolysaccharide and D-galactosamine-induced fulminant hepatic failure by activating PPARγ.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Infectious Diseases, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. Electronic address:

Geraniol (GOH), a natural component of plant essential oils, exhibits potent antioxidant and anti-inflammatory properties. The aim of this study was to assess the protective effects and mechanisms of GOH on lipopolysaccharide (LPS)/d-galactosamine (D-GalN)-induced fulminant hepatic failure (FHF). Mice were treated with GOH (12. Read More

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December 2018
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An optimized protocol for the analysis of house dust mite (Dermatophagoides farinae)-induced neutrophil-dominant airway inflammation.

J Immunol Methods 2018 Dec 11. Epub 2018 Dec 11.

Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan; AMED-CREST, AMED, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address:

House dust mites (HDMs), Dermatophagoides sp., are one of the most widespread aeroallergens worldwide and cause various allergic diseases, including asthma. The pathophysiology of asthma has been intensively investigated using murine models of allergic airway inflammation induced by exposure to D. Read More

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December 2018

NEW PROPOSAL FOR THE PATHOPHYSIOLOGY OF TYPE 3 NEOVASCULARIZATION AS BASED ON MULTIMODAL IMAGING FINDINGS.

Authors:
Richard F Spaide

Retina 2018 Dec 6. Epub 2018 Dec 6.

Vitreous, Retina, Macula Consultants of New York, New York.

Purpose: To investigate the imaging characteristics of early Type 3 neovascularization and propose a new pathophysiologic sequence for early disease.

Methods: Patients were evaluated with a comprehensive ophthalmologic examination to include fundus photography, optical coherence tomography, optical coherence tomography angiography, fluorescein angiography, and volume-rendered optical coherence tomography angiography. Relevant literature was also reviewed. Read More

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December 2018

Enhanced Recovery Pathways: Looking Into the Future.

Anesth Analg 2019 Jan;128(1):5-7

Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.

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January 2019

Anesthesia in Patients With Multiple-System Atrophy: A Narrative Review and Practice Guidance.

A A Pract 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas.

Multiple-system atrophy, a rare adult-onset neurodegenerative disease, is associated with autonomic dysfunction, features of parkinsonism, and cerebellar ataxia. This article discusses multiple-system atrophy pathophysiology, clinical presentation, and perioperative issues pertinent to anesthesia. Read More

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December 2018

Effects of apolipoprotein E on nutritional metabolism in dementia.

Curr Opin Lipidol 2018 Dec 12. Epub 2018 Dec 12.

Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Healthcare System.

Purpose Of Review: Various groups have explored the effect of apolipoprotein E (APOE) on neurodegeneration through nutritional and metabolic alterations. In this review, we hope to summarize recent findings in humans as well as preclinical APOE models.

Recent Findings: Metabolic pathways including lipid metabolism appear to play a large role in the pathophysiology of Alzheimer's disease. Read More

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December 2018

Vitamin K: a nutrient which plays a little-known role in glucose metabolism.

Curr Opin Clin Nutr Metab Care 2018 Dec 12. Epub 2018 Dec 12.

Sorbonne Université, Diabetes Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris.

Purpose Of Review: Type 2 diabetes is one of the most important public health diseases. Type 2 diabetes pathophysiology involves multiple pathways, in which micronutrients could play a role. Among them, interest has grown concerning vitamin K. Read More

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December 2018

Pulmonary hypertension in patients with a history of intravenous drug use.

Curr Med Res Opin 2018 Dec 14:1-14. Epub 2018 Dec 14.

a Cardiovascular Department , John Hunter Hospital , Newcastle NSW , Australia.

Objective: Pulmonary hypertension may be a consequence of intrinsic elevation in pulmonary vasculature resistance or complicate numerous other conditions affecting the cardiac and respiratory systems. In this review we sought to explore the relationship between pulmonary hypertension and intravenous drug use.

Methods: A narrative review was conducted using PubMed MeSH search with further papers were identified using a standard PubMed search with relevant key terms and various synonyms. Read More

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December 2018
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Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics.

FASEB J 2018 Dec 14:fj201801843R. Epub 2018 Dec 14.

Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Bioenergetic failure, oxidative stress, and changes in mitochondrial morphology are common pathologic hallmarks of amyotrophic lateral sclerosis (ALS) in several cellular and animal models. Disturbed mitochondrial physiology has serious consequences for proper functioning of the cell, leading to the chronic mitochondrial stress. Mitochondria, being in the center of cellular metabolism, play a pivotal role in adaptation to stress conditions. Read More

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December 2018

[The becoming of reactions of lipolysis in phylogenesis. The palmitic and oleic triglycerides as substrates. Insulin, condition of normolipemia and formation of hyper lipoproteinemia type IIb, IV and V].

Klin Lab Diagn 2018 ;63(1):4-15

The Federal state budget scientifc institution "The research institute of general pathology and pathophysiology" of the Russian academy of sciences, 125315, Moscow, Russia.

According to phylogenetic theory of general pathology, when living in ocean all were carnivorous (piscivorous) fatty acids transferring to cells in form of non-polar triglycerides nitially began apoB-48 chylomicrons, continued lipoproteins of very low and low density and fnalized its apoB-100 endocytosis. The fatty acids are transferred by chylomicrons + lipoproteins of very low density + lipoproteins of low density and non-polar triglycerides are hydrolyzed by hepatic glycerolhydrogenase and co-enzyme apoC-III; according WHO classifcation, hyperlipoproteinemia corresponds to type V. On land, in herbivorous who are not yet synthesized insulin, apoB-48 and chylomicrons left process of non-polar triglycerides transferring. Read More

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January 2018
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A Double-Blind, Randomized, Placebo-Controlled Study of Aspirin and N-Acetylcysteine as Adjunctive Treatments for Bipolar Depression.

J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.

Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.

Objective: Neuroinflammation has been implicated in the pathophysiology of bipolar disorder. Some evidence shows that nonsteroidal anti-inflammatory drugs (NSAIDs) have promising antidepressant effects. The antioxidant N-acetylcysteine (NAC) may enhance the effects of NSAIDs. Read More

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December 2018

Acid Sensing Ion Channel 2: a new potential player in the pathophysiology of multiple sclerosis.

Eur J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

Acid Sensing Ion Channel (ASICs) are proton-gated channels involved in multiple biological functions such as: pain modulation, mechanosensation, neurotransmission and neurodegeneration. Earlier, we described the genetic association, within the Nuoro population, between multiple sclerosis (MS) and rs28936, located in ASIC2 3'UTR. Here we investigated the potential involvement of ASIC2 in MS inflammatory process. Read More

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December 2018
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Identification of potential prognostic TF-associated lncRNAs for predicting survival in ovarian cancer.

J Cell Mol Med 2018 Dec 13. Epub 2018 Dec 13.

The First Affiliated Hospital, Harbin Medical University, Harbin, China.

The pathophysiology of ovarian cancer (OV) is complex and depends on multiple biological processes and pathways. Therefore, there is an urgent need to identify reliable prognostic biomarkers for predicting clinical outcomes and helping personalize treatment of OV. A long non-coding RNA (lncRNA)-based risk score model was constructed to infer the prognostic efficacy of transcription factors (TFs) based on the OV dataset from The Cancer Genome Atlas. Read More

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December 2018

Dysfunctional endothelial progenitor cells in patients with Hodgkin's lymphoma in complete remission.

Cancer Med 2018 Dec 13. Epub 2018 Dec 13.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Patients with a history of Hodgkin's lymphoma (HL) are at increased long-term risk of cardiovascular morbidity and mortality. Studies report an association between the pathophysiology of coronary artery disease (CAD) and levels of circulating endothelial progenitor cells (EPC), which play an essential role in vascular injury repair. The aim of the present study was to investigate the potential involvement of abnormal EPC level or function in the CAD risk of survivors of HL in remission. Read More

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December 2018

Review of rodent hypertensive glaucoma models.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong.

Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a primary risk factor for the development and progression of glaucoma. Rodent models of glaucoma have greatly improved our understanding of the pathophysiology of glaucoma and served as a useful tool to investigate neuroprotective agents. Read More

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December 2018

Enkephalinase inhibitors, potential therapeutics for the future treatment of diarrhea predominant functional gastrointestinal disorders.

Neurogastroenterol Motil 2018 Dec 14:e13526. Epub 2018 Dec 14.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.

The endogenous opioid system (EOS) is considered being a crucial element involved in the pathophysiology of irritable bowel syndrome (IBS) as it regulates gastrointestinal (GI) homeostasis through modulation of motility and water and ion secretion/absorption. Along with opioid receptors (ORs), the following components of EOS can be distinguished: 1. endogenous opioid peptides (EOPs), namely enkephalins, endorphins, endomorphins and dynorphins, and 2. Read More

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December 2018

Tetrasomy 18p: The challenges of noninvasive prenatal testing and combined test.

J Obstet Gynaecol Res 2018 Dec 13. Epub 2018 Dec 13.

Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Circulating cell-free DNA, having no procedural risk of miscarriage, is the most suitable sample for a noninvasive prenatal testing (NIPT). Here we report on a boy, who came to our attention for hypotonia and psychomotor delay when he was 16 months old. During the pregnancy his mother performed a NIPT that resulted compatible with the presence of trisomy 18. Read More

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December 2018

Insights into the Pulmonary Vascular complications of heart failure with Preserved Ejection Fraction.

J Physiol 2018 Dec 13. Epub 2018 Dec 13.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) is a growing public health problem that is increasing in prevalence. While PH-HFpEF is defined by a high mean pulmonary artery pressure, high left ventricular end-diastolic pressure and a normal ejection fraction, some HFpEF patients develop PH in the presence of pulmonary vascular remodeling with a high transpulmonary pressure gradient or pulmonary vascular resistance. Aging, increased left atrial pressure and stiffness, mitral regurgitation, as well as features of metabolic syndrome, which include obesity, diabetes, and hypertension, are recognized as risk factors for PH-HFpEF. Read More

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December 2018

Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches.

Compr Physiol 2018 Dec 13;9(1):75-125. Epub 2018 Dec 13.

St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.

Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. Read More

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December 2018
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Interplay between microRNAs and Wnt, transforming growth factor-β, and bone morphogenic protein signaling pathways promote osteoblastic differentiation of mesenchymal stem cells.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Osteoblasts are terminally differentiated cells with mesenchymal origins, known to possess pivotal roles in sustaining bone microstructure and homeostasis. These cells are implicated in the pathophysiology of various bone disorders, especially osteoporosis. Over the last few decades, strategies to impede bone resorption, principally by bisphosphonates, have been mainstay of treatment of osteoporosis; however, in recent years more attention has been drawn on bone-forming approaches for managing osteoporosis. Read More

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December 2018

3T chemical shift-encoded MRI: Detection of altered proximal femur marrow adipose tissue composition in glucocorticoid users and validation with magnetic resonance spectroscopy.

J Magn Reson Imaging 2018 Dec 12. Epub 2018 Dec 12.

New York Langone Health, Department of Radiology, New York University School of Medicine, New York, New York, USA.

Background: Osteoporosis (OP) results in weak bone and can ultimately lead to fracture. Drugs such as glucocorticoids can also induce OP (glucocorticoid-induced osteoporosis [GIO]). Bone marrow adipose tissue composition and quantity may play a role in OP pathophysiology, but has not been thoroughly studied in GIO compared to primary OP. Read More

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December 2018

Advances in the understanding of headache in idiopathic intracranial hypertension.

Curr Opin Neurol 2018 Dec 12. Epub 2018 Dec 12.

Metabolic Neurology, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston.

Purpose Of Review: To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH).

Recent Findings: The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified as having migraine. A larger proportion of those with IIH have a past medical history of migraine, compared with the general population, highlighting the importance of re-examining those who have a change or escalation in their headache. Read More

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December 2018
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Update on the diagnosis and management of acute heart failure.

Curr Opin Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiology, Canadian VIGOUR Centre, University of Alberta, Edmonton.

Purpose Of Review: To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies.

Recent Findings: We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Read More

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December 2018

The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Aβ25-35 triggered in SH-SY5Y cell.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):119. Epub 2018 Dec 14.

Department of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.

Background: Accumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development of Alzheimer's disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesis of AD. However, regarding whether miRNA is involved in the accumulation of Aβ in AD, the underlying molecule mechanism remains unclear. Read More

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December 2018

Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population.

BMC Cardiovasc Disord 2018 Dec 14;18(1):237. Epub 2018 Dec 14.

Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Background: Klotho, possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). The present study was carried out aiming to investigate the association of Klotho-rs564481 (C1818T) gene polymorphism with hypertension and CAD.

Methods: A total of 286 CAD-suspicious subjects were entered into this case-control study. Read More

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December 2018

[Innovation in the incorporation of macronutrients to enteral nutrition formulas].

Nutr Hosp 2018 Apr 3;35(Spec no2):4-12. Epub 2018 Apr 3.

.

Enteral nutrition consists of the administration of chemically defined nutrients which are partially or fully metabolised in the intestinal tract, by the oral route or through a tube, to get an adequate and efficient nutritional supply. Enteral nutrition is the first option when one needs artificial nutrition, keeping parenteral nutrition only for those cases for which enteral nutrition would be insufficient or impossible. Enteral nutrition formulas are classified according to their composition with complete or uncompleted supply of nutrients, administration route, and protein content, energy density and type and content of fibre, and in second term according to general or special purposes utilization. Read More

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[Pathophysiology and histology of heart failure].

Authors:
Tomohito Ohtani

Nihon Rinsho Meneki Gakkai Kaishi 2016 08;74 Suppl 6:345-8

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Retroperitoneal fibrosis. Exceptional cause of renal artery thrombosis with secondary hypertension. A case from University Mohamed V, CheikhZaid Hospital, Rabat, March 2013.

J Cardiol Cases 2014 Jan 13;9(1):26-28. Epub 2013 Dec 13.

Urology, Avicene IBN SINA University Hospital, Rabat, Morocco.

Retroperitoneal fibrosis is a rare cause of renal artery thrombosis, being the origin of renovascular hypertension, especially in patients less than thirty years old female, without particular medical history. A clinical case we present is a young 24 years old girl with no past history, hospitalized for the discovery of hypertension. She consulted for headache and progressive bilateral back pain, evolving for several months. Read More

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January 2014

An infant with primary pulmonary vein stenosis, associated with fatal occlusion of intraparenchymal small pulmonary veins.

J Cardiol Cases 2014 Jan 12;9(1):3-7. Epub 2013 Dec 12.

Japanese Research Institute of Pulmonary Vasculature, Japan.

Primary pulmonary vein stenosis (PVS) is rare within the pediatric population and its pathophysiology remains unclear, especially as to how the histopathology relates to its refractoriness to treatment. We report the case of a 4-month-old girl with primary PVS. The lesion in this patient was characterized by fatal obstruction of intraparenchymal small pulmonary veins, associated with localized stenosis at the four pulmonary veno-atrial junctions. Read More

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January 2014

ST-segment elevation myocardial infarction in a patient with anomalous origin of left circumflex coronary artery.

J Cardiol Cases 2015 Apr 13;11(4):120-123. Epub 2015 Feb 13.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

We present a case of ST-segment elevation myocardial infarction in the territory of an anomalous left circumflex coronary artery running through the retroaortic region. coronary imaging with intravascular ultrasound visualized the usual atherosclerotic change and subsequent plaque rupture and thrombus formation at the culprit lesion. The clarification of pathologic mechanisms underlying the myocardial infarction case could provide information about pathophysiology of atherosclerotic development in anomalous left circumflex coronary artery, and could help in decision-making regarding the management strategy. Read More

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A case of chemoradiotherapy-associated cardiotoxicity that developed into acute heart failure with progressive subendocardial fibrosis.

J Cardiol Cases 2014 Sep 10;10(3):115-120. Epub 2014 Jul 10.

Department of Breast Surgery, Niigata Cancer Center Hospital, Niigata, Japan.

We describe the case of a 61-year-old Japanese woman who developed acute heart failure 5 years after chemoradiotherapy for breast cancer. The patient received less than the cardiotoxic dose of docetaxel, epirubicin, cyclophosphamide, and fluorouracil and experienced no cardiovascular complications in the 5 years between the onset of chemoradiotherapy and the onset of acute heart failure. Cardiac catheterization was performed and elevation of end diastolic pressure of both ventricles was observed. Read More

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September 2014

[Silent myocardial ischemia : epidemiology and pathophysiology].

Nihon Rinsho Meneki Gakkai Kaishi 2016 08;74 Suppl 6:319-22

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The Language of Caring: Quantitating Medical Practice Patterns using Symbolic Dynamics.

Math Model Nat Phenom 2010 28;5(3):165-172. Epub 2010 Apr 28.

Departments of Critical Care Medicine and Medicine, University of Pittsburgh and Pittsburgh Veterans Affairs Healthcare System.

Real-world medical decisions rarely involve binary sole condition present or absent-patterns of patient pathophysiology. Similarly, provider interventions are rarely unitary in nature: the clinician often undertakes multiple interventions simultaneously. Conventional approaches towards complex physiologic derangements and their associated management focus on the frequencies of joint appearances, treating the individual derangements of physiology or elements of intervention as conceptually isolated. Read More

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INTESTINAL OBSTRUCTION CAUSED BY APPENDICITIS: A SYSTEMATIC REVIEW.

J West Afr Coll Surg 2017 Jul-Sep;7(3):94-115

Department of Surgery, National Hospital, Garki, Abuja, Nigeria.

Background: The known complications of appendicitis include perforated appendicitis with generalised peritonitis, appendiceal mass, appendiceal abscess, sepsis, adhesion formation and in a few occasions, small bowel intestinal obstruction.

Aim: To review published cases of intestinal obstruction due to appendicitis with a view to better understand the pathophysiology of this complication.

Methodology: A search of the literature in the MEDLINE database, using PubMed and OvidSP, Scopus, Google Scholar and Cochrane Databases with the following MeSH terms: was done. Read More

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December 2018

Concomitant takotsubo cardiomyopathy with PRES syndrome: A coincidence or a real heart-brain connection?

J Cardiol Cases 2015 Aug 1;12(2):48-51. Epub 2015 May 1.

Department of Cardiovascular Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.

Takotsubo cardiomyopathy is a clinical entity characterized by reversible ventricular dysfunction in the absence of obstructive coronary artery disease. Posterior reversible encephalopathy syndrome is another rare clinical syndrome characterized by reversible neurological symptoms. Concomitant occurrence is increasingly reported leading to credence to hypothesis of "heart-brain connection". Read More

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Myocardial infarction in a premenopausal woman with a decreased serum estrogen level due to leuprorelin acetate.

J Cardiol Cases 2010 Jun 6;1(3):e171-e175. Epub 2010 Feb 6.

Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

A 45-year-old premenopausal woman was admitted with acute myocardial infarction. Her serum estrogen level was decreased because of leuprorelin acetate administration, 3 months prior to admission for the treatment of uterine myoma. Emergency coronary angiography revealed diffuse narrowing of the distal half of the left anterior descending artery (LAD). Read More

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Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A.

AAPS J 2018 Dec 13;21(1). Epub 2018 Dec 13.

Department of OMNI Biomarker Development, Genentech Inc, South San Francisco, California, USA.

The interleukin (IL)-17 pathway has been implicated in the pathophysiology of many autoimmune diseases. MCAF5352A is a humanized monoclonal antibody which targets both IL-17A and IL-17F, thereby inhibiting the activity of IL-17 dimers (IL-17AA, IL-17AF, and IL-17FF). The pharmacokinetic profile of MCAF5352A has been characterized in both a Phase Ia single ascending dose study and a Phase Ib multiple ascending dose study. Read More

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December 2018

Fabrication of composite microfluidic devices for local control of oxygen tension in cell cultures.

Lab Chip 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Oxygen tension is a central component of the cellular microenvironment and can serve as a trigger for changes in cell phenotype and function. There is a strong need to precisely control and modulate oxygen tension in cell culture systems in order to more accurately model the physiology and pathophysiology observed in vivo. The objective of this paper was to develop a simple, yet effective strategy for local control of oxygen tension in microfluidic cell cultures. Read More

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December 2018

Editorial: Bioscience of D-amino Acid Oxidase From Biochemistry to Pathophysiology.

Front Mol Biosci 2018 28;5:108. Epub 2018 Nov 28.

Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan.

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November 2018

Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases.

Allergo J Int 2018 9;27(8):245-255. Epub 2018 Jul 9.

9Jenner Institute, University of Oxford, Oxford, UK.

Background: Apart from active allergen avoidance, immunotherapy is regarded as the most effective form of treatment available for type I allergies. Such treatments involve the administration of allergen preparations in various forms and by various routes. Virus-like particles (VLPs) offer a very effective platform for immunization with the allergen and are characterized by high immunogenicity, low allergenicity and high clinical efficacy. Read More

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Phospholipase A in skin biology: new insights from gene-manipulated mice and lipidomics.

Inflamm Regen 2018 7;38:31. Epub 2018 Dec 7.

1Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan.

The skin represents one of the tissues that are most profoundly influenced by alterations in the quality of lipids (lipoquality). Lipids not only constitute cellular membranes, but also serve as bioactive lipid mediators and essential components of the skin barrier. Phospholipase A (PLA) enzymes supply fatty acids and lysophospholipids from membrane phospholipids, thereby variably affecting cutaneous homeostasis. Read More

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December 2018
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p53-Sensitive Epileptic Behavior and Inflammation in Hypomorphic Mice.

Front Genet 2018 27;9:581. Epub 2018 Nov 27.

Department of Biology and Biotechnology, Sapienza University of Rome, Rome, Italy.

Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are mostly preferred. Read More

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November 2018

Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation.

Sci Rep 2018 Dec 13;8(1):17834. Epub 2018 Dec 13.

Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Next to progressive airway disease, CF is also associated with intestinal inflammation and dysbiosis. Ivacaftor, a CFTR potentiator, has improved pulmonary and nutritional status but its effects on the intestinal microbiota and inflammation are unclear. Read More

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December 2018
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