3,281,052 results match your criteria Pathology research and practice[Journal]


Locating the foramen ovale by using molar and inter-eminence planes: a guide for percutaneous trigeminal neuralgia procedures.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

Departments of1Natural Sciences and Mathematics and.

OBJECTIVEThe first attempt to cannulate the foramen ovale is oftentimes unsuccessful and requires subsequent reattempts, thereby increasing the risk of an adverse event and radiation exposure to the patient and surgeon. Failure in cannulation may be attributable to variation in soft-tissue-based landmarks used for needle guidance. Also, the incongruity between guiding marks on the face and bony landmarks visible on fluoroscopic images may also complicate cannulation. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182276DOI Listing
February 2019

Adjuvant androgen deprivation therapy for poor-risk, androgen receptor-positive salivary duct carcinoma.

Eur J Cancer 2019 Feb 13;110:62-70. Epub 2019 Feb 13.

Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, the Netherlands. Electronic address:

Aim: Salivary duct carcinoma (SDC), an aggressive subtype of salivary gland cancer, is androgen receptor (AR)-positive in 67-96% of cases. In patients with locally recurrent and metastatic (R/M) AR-positive SDC, androgen deprivation therapy (ADT) has an overall response rate of 18-64.7%. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.035DOI Listing
February 2019

Circulating CD14CD163CD209 M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients.

Mol Immunol 2019 Feb 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.017DOI Listing
February 2019

Temporal and geographical variations in colorectal cancer incidence in Northern Iran 2004-2013.

Cancer Epidemiol 2019 Feb 13;59:143-147. Epub 2019 Feb 13.

Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Genetic Epidemiology Group, Folkhälsan Research Center, Faculty of Medicine, Helsinki University, Helsinki, Finland; Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

Introduction: Colorectal cancer (CRC) is one of the most common cancers in the Golestan province, Northern Iran. The purpose of this study is to describe colorectal cancer incidence patterns and trends in the province 2004-2013.

Methods: Data on CRC cases were obtained from the Golestan Population-based Cancer Registry (GPCR). Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.003DOI Listing
February 2019

SELDI-TOF MS Analysis of Hepatocellular Carcinoma in an Australian Cohort.

J Surg Res 2019 Feb 13;238:127-136. Epub 2019 Feb 13.

Cancer Surgery and Metabolism Research Group, University of Sydney, Kolling Institute of Medical Research, St Leonards, NSW, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, NSW, Australia; Discipline of Surgery, The University of Sydney, Camperdown, NSW, Australia.

Background: Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Resection offers the best chance of long-term survival, but a consistent adverse prognostic factor is the presence of microvascular invasion (MVI). In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), a high throughput method of analyzing complex samples, was used to explore differentially expressed proteins between HCC and adjacent nontumour liver tissue (ANLT). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.008DOI Listing
February 2019

Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38/MAPK and MEK/ERK signal pathway.

Ecotoxicol Environ Saf 2019 Feb 13;173:142-148. Epub 2019 Feb 13.

Department of Geriatric Endocrinology, Geriatric Hospital of Nanjing Medical University, Luojia Road 30, Nanjing 210024, China. Electronic address:

Microcystin-LR (MC-LR) is the most toxic and abundant microcystin that produced by cyanobacteria. Previous studies have shown MC-LR had acute toxic to thyroid, however, the mechanism is still unclear, and the effect of long-term, low-dose MC-LR on thyroid remains uncertain. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse thyroid tissues and thyroid hormone metabolism. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.024DOI Listing
February 2019

Utility of Likert scale (Deauville criteria) in assessment of Chemoradiotherapy response of primary oropharyngeal squamous cell Cancer site.

Clin Imaging 2019 Jan 16;55:89-94. Epub 2019 Jan 16.

Department of Radiology, Division of Nuclear Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Introduction: The aim of this study is to determine whether Likert scale (Deauville criteria) can be used to classify oropharyngeal squamous cell cancer (OPSCC) patients as 'responders' and 'nonresponders' by utilizing FDG-PET/CT for primary tumor site. The second aim is to compare the performance of methods used in interpretation of posttreatment PET/CT scans (Likert scale, SUVmax, ratios of SUVmax primary lesion to mediastinum 'SUVmax P/M' and SUVmax primary lesion to liver 'SUVmax P/L') in predicting treatment response.

Methods: Seventy-seven PET/CT scans were assessed by Deauville criteria, five-point Likert scale. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.007DOI Listing
January 2019

The detection of BKPyV genotypes II and IV after renal transplantation as a simple tool for risk assessment for PyVAN and transplant outcome already at early stages of BKPyV reactivation.

J Clin Virol 2019 Feb 10;113:14-19. Epub 2019 Feb 10.

Institute for Virology, University Hospital Essen, University of Duisburg-Essen Virchowstr. 179, 45147, Essen, Germany.

Background: After reactivation the BK-polyomavirus (BKPyV) associated nephropathy (PyVAN) is observed in 1-10% of renal transplant recipients, of which up to 80% undergo graft failure. BKPyV reactivation after renal transplantation was associated with donor-derived serotypes against which the recipient has no immunological protection. However, PyVAN risk assessment seroactivity testing is a time-consuming and cost intensive process. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.02.002DOI Listing
February 2019

Trial of intrathecal rituximab in progressive multiple sclerosis patients with evidence of leptomeningeal contrast enhancement.

Mult Scler Relat Disord 2019 Feb 11;30:136-140. Epub 2019 Feb 11.

Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 627, Baltimore, MD 21287, USA.

Background: Leptomeningeal inflammation is associated with increased cortical damage and worse clinical outcomes in MS. It may be detected on contrast-enhanced T2-FLAIR imaging as focal leptomeningeal contrast-enhancement (LME).

Objective: To assess the safety of intrathecal (IT) rituximab in progressive MS (PMS) and to assess its effects on LME and CSF biomarkers. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.013DOI Listing
February 2019

Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Maternal Fetal Medicine Unit. Department of Obstetrics. Hospital Universitari Vall d'Hebron. Ps. Vall d'Hebron 119-129, 08035 Barcelona. Universitat Autònoma de Barcelona.

Objectives: to describe pregnancy outcomes after Zika virus (ZIKV) infection in a non-endemic region.

Methods: according to the Spanish protocol issued after the ZIKV outbreak in Brazil in 2015, all pregnant women who had travelled to high-burden countries were screened for ZIKV. Serological and molecular tests were used to identify ZIKV-infected pregnant women. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.008DOI Listing
February 2019

Chk1 inhibition enhances cisplatin cytotoxicity and overcomes cisplatin resistance in small cell lung cancer by promoting mitotic cell death.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Oncology, Georgetown University Medical Center, Washington, DC. Electronic address:

Introduction: Platinum-based chemotherapy remains the standard treatment for patients with small cell lung cancer (SCLC), but the benefit of the treatment is often hampered by rapid development of drug resistance. Thus far, there is no targeted therapy available for SCLC. Over 90% of SCLC tumors harbor mutations in the tumor suppressor gene p53, an important DNA damage checkpoint regulator, and these tumor cells rely predominantly on the checkpoint kinases to control DNA damage response. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.01.028DOI Listing
February 2019

Viral genome integration of canine papillomavirus 16.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.

Papillomaviruses infect humans and animals, most often causing benign proliferations on skin or mucosal surfaces. Rarely, these infections persist and progress to cancer. In humans, this transformation most often occurs with high-risk papillomaviruses, where viral integration is a critical event in carcinogenesis. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.002DOI Listing
February 2019

Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review.

Drug Discov Today 2019 Feb 13. Epub 2019 Feb 13.

Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address:

Natural killer (NK) cells are innate immune lymphocytes with a key role in host defense against HIV infection. Recent advances in chimeric antigen receptors (CARs) have made NK cells a prime target for expressing recombinant receptors capable of redirecting NK cytotoxic functions towards HIV-infected cells. In this review, we discuss the role of NK cells in HIV and the mechanisms of actions of HIV-targeting CAR strategies. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.02.002DOI Listing
February 2019

Velogenic newcastle disease virus tissue tropism and pathogenesis of infection in chickens by application of in situ PCR, immunoperoxase staining and HE staining.

Microb Pathog 2019 Feb 13. Epub 2019 Feb 13.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Limited deep studies are available in the field of early stages of pathogenesis of Newcastle disease virus (NDV) infection and tissue tropism of NDV. In this study, 24 specific pathogen free (SPF) chickens of white leghorn breed were infected with Newcastle disease (ND) by intranasal administration of 10⁵ 50% EID50/0.1 mL of velogenic NDV (vNDV). Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.017DOI Listing
February 2019

TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

DNA hypermethylation is a driving force in carcinogenesis. However, the role of active DNA hypomethylation in cancer remains largely unknown. This process, facilitated by ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which oxidizes 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), has never been studied in cervical cancer. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.033DOI Listing
February 2019

Metformin Induces Human Esophageal Carcinoma Cell Pyroptosis by Targeting the miR-497/PELP1 Axis.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Institute of Precision Cancer Medicine and Pathology, And Department of Pathology, Jinan University Medical College, Guangzhou, China; Department of Immunotherapy and Tumor Tissue Bank, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. Electronic address:

Evasion of apoptosis is a major contributing factor to the development of chemo- and radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death (PCD) could be an effective alternative against apoptosis-resistant cancers. In this study, we demonstrated in vitro and in vivo that metformin can induce pyroptosis, a non-apoptotic PCD, in esophageal squamous cell carcinoma (ESCC), a commonly known chemo-refractory cancer, especially at its advanced stages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193008
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http://dx.doi.org/10.1016/j.canlet.2019.02.014DOI Listing
February 2019
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IN SITU hybridization FOR THE LOCALIZATION OF TWO PEPINO MOSAIC VIRUS ISOLATES IN MIXED INFECTIONS.

J Virol Methods 2019 Feb 13. Epub 2019 Feb 13.

Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Departamento de Biología del Estrés y Patología Vegetal, Murcia, Spain. Electronic address:

In situ hybridization (ISH) is an informative and relatively accessible technique for the localization of viral genomes in plant tissue and cells. However, simultaneous visualization of related plant viruses in mixed infections may be limited by the nucleotide similarity in the genomes and the single chromogenic detection over the same sample preparation. To address this issue, we used two Pepino mosaic virus isolates and performed ISH over consecutive serial cross-sections of paraffin-embedded leaf samples of single and mixed infected Nicotiana benthamiana plants. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.02.003DOI Listing
February 2019

Localized Surface Plasmon Resonance Biosensing of Tomato Yellow Leaf Curl Virus.

J Virol Methods 2019 Feb 13. Epub 2019 Feb 13.

Department of biotechnology and plant breeding, faculty of agriculture, Ferdowsi university of Mashhad, Iran.

Current techniques for plant virus detection, such as RT- PCR and ELISA, require multistep procedures and rely on sophisticated equipment. Due to the global spread of plant viruses, the development of simpler, faster and cheaper assay methods is inevitable. Gold nanoparticles (AuNPs) had raised much interest during recent years due to their novel optical properties or diagnostic purposes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934183028
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http://dx.doi.org/10.1016/j.jviromet.2019.02.004DOI Listing
February 2019
1 Read

Immunoglobulin G4 Inflammatory Aortic Aneurysm Mimicking Acute Aortic Syndrome.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthopedics and Trauma - Surgery, Division of Trauma - Surgery, General Hospital of Vienna, Austria.

Immunoglobulin-G4-related disease (IgG4RD) is a novel clinical entity characterized by lymphoplasmacytic infiltrates presenting as an excessive fibrosis such as retroperitoneal inflammatory pseudotumor but rarely affecting the heart or the aorta. We describe a case of IgG4RD with multifocal aortic involvement presenting as an acute aortic syndrome. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.029DOI Listing
February 2019

A pediatric case of Staphylococcus lugdunensis-induced infective endocarditis at bovine jugular vein.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of cardiovascular surgery, Mt. Fuji Shizuoka children's hospital, Shizuoka, Japan.

A 2-year-old boy underwent right ventricular outflow tract reconstruction (RVOTR) with a bovine jugular vein graft. He presented with high fever on postoperative day 6. Blood and drainage effusion cultures were all positive for S. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.028DOI Listing
February 2019

SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.

J Mol Cell Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Physiology, University of Wuerzburg, Germany. Electronic address:

Cardiac functionality is dependent on a balanced protein turnover. Accordingly, regulated protein decay is critical to maintain cardiac function. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in human heart, resulted in impaired autophagy, heart failure, and shortened lifespan. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.023DOI Listing
February 2019

Hematology reference intervals for transgender adults on stable hormone therapy.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States.

Background: The complete blood count (CBC) is a cornerstone of patient care. Several of the normal values for the components of the CBC differ by sex and, therefore, male-specific and female-specific reference intervals are required to interpret these laboratory results. Transgender individuals are often prescribed hormone therapy to affirm their gender, with resulting serum hormone concentrations similar to those of cisgender individuals. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.011DOI Listing
February 2019

Correct implementation of the Hoffmann method.

Authors:
Daniel T Holmes

Clin Biochem 2019 Feb 13. Epub 2019 Feb 13.

University of British Columbia, Department of Pathology and Laboratory Medicine, Rm. G227 - 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.02.007DOI Listing
February 2019

Growth response of dental tissues to developmental stress in the domestic pig (Sus scrofa).

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

School of Anthropology and Conservation, University of Kent, Canterbury, United Kingdom.

Objectives: To compare relative response of enamel, dentin and bone to developmental stressors between attritional and catastrophic mortality assemblages of pigs.

Materials And Methods: Heads from 70 Sus scrofa of known sex, weight and age comprising an attritional sample of 50 sick pen (SP) pigs that died prematurely versus 20 control pigs slaughtered at 6 months (Catastrophic assemblage). Hard tissue changes (alveolar bone thinning), abnormal bone formation (Harris lines) and re-modeling (auditory bullae) were recorded. Read More

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http://dx.doi.org/10.1002/ajpa.23795DOI Listing
February 2019

Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults.

Cancer Sci 2019 Feb 16. Epub 2019 Feb 16.

Division of Screening for Molecular Target of Cancer, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Gastric cancer in young adults has been pointed out to comprise a subgroup associated with distinctive clinicopathological features, including an equal gender distribution, advanced disease and diffuse-type histology. Comprehensive molecular analyses of gastric cancers have led to molecular-based classifications and to specific and effective treatment options available. The molecular traits of gastric cancers in young adults await investigations, which should provide a clue to explore therapeutic strategies. Read More

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http://dx.doi.org/10.1111/cas.13967DOI Listing
February 2019

Evaluating the properties of a frailty index and its association with mortality risk among patients with systemic lupus erythematosus.

Arthritis Rheumatol 2019 Feb 16. Epub 2019 Feb 16.

Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in SLE.

Methods: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/ACR Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36]) were assessed. The SLICC-FI was constructed using baseline data. Read More

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http://doi.wiley.com/10.1002/art.40859
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http://dx.doi.org/10.1002/art.40859DOI Listing
February 2019
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N-myc and STAT interactor correlates with severity and prognosis in acute-on-chronic liver failure of hepatitis B virus.

J Gastroenterol Hepatol 2019 Feb 16. Epub 2019 Feb 16.

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China.

Background And Aim: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by acute deterioration of chronic liver disease with excessive inflammation. N-myc and STAT interactor (NMI), an inflammation-mediated protein, involves in various inflammatory related diseases, but the role of NMI in development and prognosis in HBV-ACLF remains to be elucidated.

Methods: Serum NMI from healthy controls (HCs, n=20), chronic hepatitis B (CHB, n=50) patients and HBV-ACLF patients (n=50) were determined using ELISA. Read More

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http://dx.doi.org/10.1111/jgh.14634DOI Listing
February 2019

Subtraction of Epstein-Barr virus and microsatellite instability genotypes from the Lauren histotypes: combined molecular and histologic subtyping with clinicopathological and prognostic significance validated in a cohort of 1,248 cases.

Int J Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Limited studies investigated clinicopathological and prognostic significance of histologic and molecular subgroups of gastric cancer concurrently. We retrospectively enrolled 1,248 patients with gastric cancer who received radical gastrectomy with lymphadenectomy and classified these cases into the Epstein-Barr virus (EBV)-associated and microsatellite instability (MSI)-associated subtypes by EBV-encoded small RNA in situ hybridization and immunohistochemical stains for DNA mismatch repair proteins, respectively. The remaining cases were categorized as the Lauren intestinal and diffuse/mixed subtypes. Read More

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http://dx.doi.org/10.1002/ijc.32215DOI Listing
February 2019

Mortality after breast cancer as a function of time since diagnosis by estrogen receptor status and age at diagnosis.

Int J Cancer 2019 Feb 16. Epub 2019 Feb 16.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, Victoria 3010, Australia.

Our aim was to estimate how long-term mortality following breast cancer diagnosis depends on age at diagnosis, tumor estrogen receptor (ER) status, and the time already survived. We used the population-based Australian Breast Cancer Family Study which followed-up 1,196 women enrolled during 1992-99 when aged <60 years at diagnosis with a first primary invasive breast cancer, over-sampled for younger ages at diagnosis, for whom tumor pathology features and ER status were measured. There were 375 deaths (median follow-up=15. Read More

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http://doi.wiley.com/10.1002/ijc.32214
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http://dx.doi.org/10.1002/ijc.32214DOI Listing
February 2019
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Calcifying Epithelial Odontogenic (Pindborg) Tumor in a Child: A Case Report and Literature Review.

Head Neck Pathol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Boston University, Boston Medical Center, Boston, MA, USA.

Calcifying epithelial odontogenic tumor (CEOT) is a rare neoplasm, which accounts for < 1% of all odontogenic tumors. CEOT occurs more frequently in adults with a peak incidence in the 5th decade of life and is extremely rare in the pediatric population. We present a case of a 13-year-old girl who was found to have a mandibular CEOT. Read More

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http://dx.doi.org/10.1007/s12105-019-01009-1DOI Listing
February 2019

Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease.

Methods Mol Biol 2019 ;1948:271-286

Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.

The use of viral vector-mediated α-synuclein-overexpressing rodent models for Parkinson's disease has become increasingly accepted to study associated pathology and to use as a platform for therapeutic efficacy testing. We here describe methods to generate such models and how to analyze them by behavioral assessments, histological investigations, and examination of nigrostriatal dopaminergic function. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_21DOI Listing
January 2019

In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.

Methods Mol Biol 2019 ;1948:235-246

Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

In this chapter, we describe a novel ascorbate peroxidase (APEX)-based labeling method that in combination with mass spectrometry identifies proteins in the immediate vicinity of αSyn in living rat cortical neurons. To isolate these interactions, we transduced primary cortical neurons with a lentivirus encoding APEX2 tagged to the C-terminus of alpha-synuclein (αSyn) and under the control of a synapsin promoter. Neural protein lysates were then incubated with streptavidin magnetic beads, washed, eluted from the beads, and digested overnight. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_18DOI Listing
January 2019

Circular Dichroism and Isothermal Titration Calorimetry to Study the Interaction of α-Synuclein with Membranes.

Authors:
Matteo Rovere

Methods Mol Biol 2019 ;1948:123-143

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

α-Synuclein's physiology and pathology have been linked by numerous reports to its ability to bind and remodel membranes, especially at synaptic terminals. It is therefore critical for researchers investigating the determinants of these interactions to rely on methods capable of providing an accurate and complete physicochemical snapshot of the binding events. Circular dichroism (CD) and isothermal titration calorimetry (ITC) are established techniques for the study of binding equilibria in biological systems and, especially when used in combination, allow a thorough characterization of the protein-lipid interplay. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_11DOI Listing
January 2019

Alpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers.

Methods Mol Biol 2019 ;1948:69-76

Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

Alpha-synuclein oligomers are thought to be toxic mediators of Parkinson's disease and other alpha-synucleinopathies, but their histological detection in situ in diseased brain has been a challenge in the field for some time. Here we describe a method, the alpha-synuclein proximity ligation assay (AS-PLA), to detect alpha-synuclein oligomers in paraffin-embedded brain sections. Using AS-PLA previously unobserved alpha-synuclein oligomeric pathology is revealed. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_7DOI Listing
January 2019

Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils.

Methods Mol Biol 2019 ;1948:45-57

Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

The accumulation of intraneuronal inclusions containing misfolded alpha-synuclein (aSyn) within the central nervous system (CNS) is a common feature found in several neurodegenerative disorders including Parkinson's disease (PD). Emerging evidence indicates that aSyn amyloid fibrils, a configuration that is present within these characteristic inclusions, are capable of self-replicating by templating the conversion of endogenously expressed aSyn in neurons. Stereotaxic administration of synthetic α-synuclein preformed fibrils (PFFs) into the mouse brain has been shown to seed the formation of intracellular aSyn pathology reminiscent of Lewy body (LB) inclusions present in human PD and related synucleinopathies. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_5DOI Listing
January 2019

Immunohistochemical Detection of Alpha-Synuclein in Unfixed Human Brain Tissue.

Authors:
John B Sanderson

Methods Mol Biol 2019 ;1948:15-22

The Warren Alpert Medical School of Brown University, Providence, RI, USA.

In both research and diagnostics, immunohistochemistry is an essential method for assessing pathology in neurodegenerative diseases. Typically, at autopsy, one hemisphere of the brain is formalin fixed for sectioning and histochemical analysis, while the other hemisphere is flash frozen for biochemical studies. While this process ensures the generation of high-quality slides, it is important to assess the pathology of tissue near pieces used for biochemical analyses, since pathology burden can be unevenly distributed throughout the brain (Fig. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_2DOI Listing
January 2019

Acute multiple sclerosis lesion pathology does not predict subsequent clinical course-a biopsy study.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuropathology, Beaumont Hospital, Beaumont Road, Dublin, Ireland.

Background: Knowledge of the clinical outcome in tumefactive demyelination remains limited.

Aims: This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population.

Methods: We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. Read More

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http://dx.doi.org/10.1007/s11845-019-01983-zDOI Listing
February 2019

Success Factors Enabling Employment for Adults on the Autism Spectrum from Employers' Perspective.

J Autism Dev Disord 2019 Feb 15. Epub 2019 Feb 15.

School of Occupational Therapy, Social Work and Speech Pathology, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.

Employment outcomes for individuals with autism spectrum disorder (ASD) are poor and there is limited understanding on how best to support individuals with ASD in the workplace. Stakeholders involved in the employment of adults with ASD, including employers and employment service providers have unique insights into the factors influencing employment for this population. Organisational and individual factors facilitating successful employment for adults with ASD across Australia and Sweden were explored, including the supports and strategies underpinning employment success from an employers' perspective. Read More

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http://dx.doi.org/10.1007/s10803-019-03923-3DOI Listing
February 2019

Pathologic findings of the removed stomach during sleeve gastrectomy.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Bariatric Surgery, Orlando Regional Medical Center, Orlando Health, Orlando, FL, USA.

Background: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. Read More

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http://dx.doi.org/10.1007/s00464-019-06689-yDOI Listing
February 2019

Amblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding.

Exp Appl Acarol 2019 Feb 15. Epub 2019 Feb 15.

Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, 39762, USA.

Rickettsia parkeri, a causative agent of spotted fever rickettsiosis, is transmitted by Amblyomma maculatum (Gulf Coast tick), a tick that may also carry a non-pathogenic spotted fever group Rickettsia, "Candidatus Rickettsia andeanae". Here, we evaluated R. parkeri and "Candidatus R. Read More

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http://dx.doi.org/10.1007/s10493-019-00343-xDOI Listing
February 2019

Pathology of the carotid space.

Insights Imaging 2019 Feb 15;10(1):21. Epub 2019 Feb 15.

Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box 648, Rochester, NY, 14642, USA.

The complex anatomy of the carotid space within a small confined area is unique to the head and neck and allows for a vast array of pathology. This paper will review the anatomy of the carotid space from the skull base to the thorax, defining its borders at multiple levels, as well as its contents. The paper will also describe the myriad of mass lesions and vascular pathologies that may occur within the carotid space. Read More

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http://dx.doi.org/10.1186/s13244-019-0704-zDOI Listing
February 2019

H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo.

Acta Neuropathol 2019 Feb 15. Epub 2019 Feb 15.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

Histone H3 K27M mutation is the defining molecular feature of the devastating pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). The prevalence of histone H3 K27M mutations indicates a critical role in DIPGs, but the contribution of the mutation to disease pathogenesis remains unclear. We show that knockdown of this mutation in DIPG xenografts restores K27M-dependent loss of H3K27me3 and delays tumor growth. Read More

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http://dx.doi.org/10.1007/s00401-019-01975-4DOI Listing
February 2019

Unusual radiological and histological presentation of a diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 13-year-old girl.

Childs Nerv Syst 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA.

Diffuse leptomeningeal glioneuronal tumors (DLGNTs) are newly recognized as an entity in the 2016 revision of the WHO Classification of tumors of the central nervous system. They typically present as diffuse leptomeningeal infiltrates along the neuraxis with focal and superficial involvement of the parenchyma. Here, we report a DLGNT with unusual radiological and histological features. Read More

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http://dx.doi.org/10.1007/s00381-019-04074-7DOI Listing
February 2019

CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.

J Cancer Res Clin Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.

Purpose: This study aimed at investigating the function and significance of CD110 expression in pancreatic cancer.

Methods: We performed immunohistochemical staining for CD110 expression in tumor samples from 86 patients with pancreatic cancer. We evaluated clinical outcomes and other clinicopathological factors to determine the significance of CD110 on survival and liver metastasis. Read More

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http://dx.doi.org/10.1007/s00432-019-02860-zDOI Listing
February 2019

Analysis of false-positive results of diatom test in the diagnosis of drowning-would not be an impediment.

Int J Legal Med 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University & Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan 2nd Road 74, Yuexiu District, Guangzhou, 510080, China.

Diatom test has been a significant tool for the diagnosis of drowning. The reliability of the diatom test is still in strong dispute in the field of forensic science because of the false-positive results. This study was designed to quantitatively compare the numbers of the diatoms in false-positive cases and true drowning cases. Read More

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http://dx.doi.org/10.1007/s00414-019-02021-4DOI Listing
February 2019

The stem cell markers expression CD44v6 and podoplanin in lip cancer: clinical significance.

Virchows Arch 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil.

This study aimed to analyze the immunoexpression of cancer stem cell markers, CD44v6, and podoplanin in 91 patients with lip squamous cell carcinomas (LSCC). The immunostaining of podoplanin and CD44v6 was evaluated in ten high-power fields (× 400 magnification) at the invasive front of LSCC, using a semi-quantitative score method. Chi-square test or Fisher's exact test was used to verify the association of podoplanin and CD44v6 expressions with clinicopathologic variables. Read More

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http://dx.doi.org/10.1007/s00428-019-02539-3DOI Listing
February 2019

Bilateral snapping biceps femoris tendon: a case report and review of the literature.

Eur J Orthop Surg Traumatol 2019 Feb 15. Epub 2019 Feb 15.

Abertawe Bro Morgannwg University Health Board, Swansea, Wales, UK.

Snapping biceps femoris tendon is an uncommon cause of lateral knee pain. We report the case of a 15-year-old athlete with bilateral snapping biceps femoris tendons, painful over his right lateral leg during exercise. He underwent elective exploration of the right knee which revealed an accessory biceps femoris tendon with attachment to the anterolateral tibia. Read More

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http://dx.doi.org/10.1007/s00590-019-02392-9DOI Listing
February 2019

SCMCIE94: an intensified pilot treatment protocol known to be associated with cure in CD 56-negative non-pelvic isolated Ewing sarcoma (EWS) is also associated with no early relapses in non-metastatic extremity EWS.

Cancer Chemother Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

The Rina Zaizov Hematology-Oncology Division, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Purpose: We report the unexpected absence of early relapse (before 30 months) in 24 consecutive patients with isolated limb primary Ewing sarcoma treated with an intensified pilot protocol, SCMCIE94.

Methods: Clinical data for the study were collected retrospectively from the patient files. The protocol included 6 courses of chemotherapy, split radiation, and limb salvage surgery. Read More

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http://dx.doi.org/10.1007/s00280-019-03789-3DOI Listing
February 2019

Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer's disease pathogenesis.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Centre of Excellence in Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, Australia.

Alzheimer's disease (AD) is a multifactorial age-related brain disease. Numerous pathological events run forth in the brain leading to AD. There is an initial long, dormant phase before the clinical symptoms become evident. Read More

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http://dx.doi.org/10.1007/s00018-019-03040-5DOI Listing
February 2019
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