3,316,189 results match your criteria Pathology research and practice[Journal]


Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma with Late Recurrence.

J Pathol Transl Med 2019 Apr 25. Epub 2019 Apr 25.

Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4132/jptm.2019.04.02DOI Listing

Effect of αvβ3 Integrin Expression and Activity on Intraocular Pressure.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1776-1788

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States.

Purpose: To determine the effects of αvβ3 integrin expression and activation on intraocular pressure (IOP).

Methods: Cre+/-β3flox/flox mice were treated with topical tamoxifen eye drops for 5 days to activate Cre and excise the β3 integrin gene from the anterior segment. IOP was measured weekly for 11 weeks using rebound tonometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.18-26038DOI Listing

Transition from video-assisted thoracoscopic to robotic esophagectomy: a single surgeon's experience.

Dis Esophagus 2019 Apr 25. Epub 2019 Apr 25.

Department of Cardiothoracic Surgery, New York University Langone Health, New York, USA.

Lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is a technically challenging part of esophageal cancer surgery, especially after chemoradiotherapy (CRT). Robotic surgery holds promise to increase its safety and feasibility. The aim of this study was to describe a single thoracoscopic surgeon's experience related to the transition from video-assisted esophagectomy (VATE) to robotic esophagectomy (RE)-with a special focus on the safety of left RLN LND. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/dote/doz033DOI Listing

Inflammatory Bowel Disease Susceptibility Gene Regulates Intestinal Epithelial Permeability.

Immunohorizons 2018 May 30;2(5):164-171. Epub 2018 May 30.

Department of Immunology Discovery, Genentech Inc., South San Francisco, CA 94080;

Intestinal epithelial cells form a physical barrier that is tightly regulated to control intestinal permeability. Proinflammatory cytokines, such as TNF-α, increase epithelial permeability through disruption of epithelial junctions. The regulation of the epithelial barrier in inflammatory gastrointestinal disease remains to be fully characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/immunohorizons.1800027DOI Listing

In vitro, in cellulo and structural characterizations of the interaction between the integrase of Porcine Endogenous Retrovirus A/C and proteins of the BET family.

Virology 2019 Apr 16;532:69-81. Epub 2019 Apr 16.

INRA, Université Lyon 1, UMR754, Viral Infections Compared Pathology, 69007, Lyon, France; Université de Lyon, 69000, Lyon, France; UMSl3444 Biosciences Gerland Lyon Sud, 69007, Lyon, France. Electronic address:

Retroviral integrase (IN) proteins catalyze the permanent integration of the viral genome into host DNA. They can productively recruit cellular proteins, and the human Bromodomain and Extra-Terminal domain (hBET) proteins have been shown to be co-factors for integration of gamma-retroviruses such as Murine Leukemia Virus (MLV) into human cells. By using two-hybrid, co-immunoprecipitation and in vitro interaction assays, we showed that IN of the gamma- Porcine Endogenous Retrovirus-A/C (PERV IN) interacts through its C-terminal domain (CTD) with hBET proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2019.04.002DOI Listing

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Apr 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular profiling of high-risk tumours to identify target alterations for potential precision therapy. We analysed molecular characteristics and clinical data after brainstem biopsy of all enrolled newly diagnosed DIPGs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
Publisher Site
http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
April 2019
1 Read

Analyzing DNA methylation patterns in subjects diagnosed with schizophrenia using machine learning methods.

J Psychiatr Res 2019 Apr 2;114:41-47. Epub 2019 Apr 2.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Electronic address:

Schizophrenia is a common mental disorder with high heritability. It is genetically complex and to date more than a hundred risk loci have been identified. Association of environmental factors and schizophrenia has also been reported, while epigenetic analyses have yielded ambiguous and sometimes conflicting results. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223956183139
Publisher Site
http://dx.doi.org/10.1016/j.jpsychires.2019.04.001DOI Listing
April 2019
1 Read

Wild owls colonized by international clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli and Salmonella Infantis in the Southern Cone of America.

Sci Total Environ 2019 Apr 13;674:554-562. Epub 2019 Apr 13.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil. Electronic address:

Extended-spectrum β-lactamases (ESBLs)-producing Enterobacteriaceae have been classified as critical priority pathogens by the World Health Organization (WHO). We have conducted a microbiological and genomic surveillance study, in order to investigate the occurrence and features of antibiotic-resistant bacteria in wild birds admitted to a wildlife rescue and rehabilitation centre in Chile. This study reports for the first time the occurrence of highly virulent ESBL-producing Escherichia coli and Salmonella enterica serovar Infantis in wild owls inhabiting the Southern Cone of America. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.04.149DOI Listing

Risk Factors for Progression Among Low-Grade Gliomas Following Gross Total Resection and Initial Observation in the Molecular Era.

Int J Radiat Oncol Biol Phys 2019 Apr 22. Epub 2019 Apr 22.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH. Electronic address:

Purpose: To identify risk factors for progression free survival (PFS) in the molecular era among patients with low-grade glioma (LGG) who undergo gross total resection (GTR) followed by initial observation.

Methods: We reviewed patients with WHO grade II LGG treated at a single institution. We included only those who underwent MRI-confirmed GTR followed by initial observation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2019.04.010DOI Listing

Genome-wide and functional analyses of tyrosine kinase-like family genes reveal potential roles in development and virulence in mosquito pathogen Pythium guiyangense.

Fungal Genet Biol 2019 Apr 22. Epub 2019 Apr 22.

Department of Entomology, Nanjing Agricultural University, Nanjing, China. Electronic address:

The tyrosine kinase-like (TKL) gene family is widely existed in most eukaryotes and participates in many biological processes, however, has been rarely studied in oomycetes. In this study we performed bioinformatic and experimental analyses to characterize TKLs in Pythium guiyangense, a promising mosquito biological control agent. Our results revealed that TKLs were widely distributed in all the detected oomycetes, but were largely expanded in P. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10871845183032
Publisher Site
http://dx.doi.org/10.1016/j.fgb.2019.04.009DOI Listing
April 2019
1 Read

Neonatal antibiotics disrupt motility and enteric neural circuits in mouse colon.

Cell Mol Gastroenterol Hepatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Physiology, The University of Melbourne, Parkville, VIC, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcmgh.2019.04.009DOI Listing

Label-free and iTRAQ proteomics analysis in the liver of zebrafish (Danio rerio) following dietary exposure to the organochlorine pesticide dieldrin.

J Proteomics 2019 Apr 22. Epub 2019 Apr 22.

Canadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, Canada; Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32611, United States. Electronic address:

The organochlorine dieldrin (DLD) bioaccumulates in lipid-rich tissues and is associated with immunosuppression, altered metabolism, and cancer. The objective was to determine the effect of DLD on the hepatic proteome in zebrafish following dietary treatment. Females were fed a control dose or one of three doses of DLD-contaminated food pellets over 21 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jprot.2019.04.012DOI Listing

Tumor Heterogeneity Index to detect HER2 amplification by next-generation sequencing: A direct comparison study with immunohistochemistry.

J Mol Diagn 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul. Electronic address:

Intratumoral heterogeneity of HER2 is common in gastric cancer (GC). However, a direct comparison between the results of HER2 immunohistochemistry (IHC) and next-generation sequencing (NGS)-based cancer panel tests has not been explored in GC. We aimed to determine optimal thresholds of HER2 overexpression to be detected by NGS with the data of 168 metastatic GC cases with known expression levels of HER2 by IHC and the copy number alteration of ERBB2 obtained by NGS test by applying tumor heterogeneity index (THI) and receiver operating characteristic curve. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2019.02.007DOI Listing

A versatile method for producing labeled or unlabeled Aβ55, Aβ40, and other β-amyloid family peptides.

Protein Expr Purif 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, United States; Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, 60637, United States. Electronic address:

We present a straightforward, versatile method for expressing and purifying β-amyloid (Aβ40) and transmembrane peptides derived from β-amyloid precursor protein (Aβ55). In principle, these methods should be applicable to other types of strongly aggregating peptides. We start with a DNA plasmid encoding a HexaHis tag with a flexible, hydrophilic linker sequence, followed by a cleavage site, and then Aβ peptides. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pep.2019.04.006DOI Listing

Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations.

Gene 2019 Apr 22. Epub 2019 Apr 22.

Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States of America.

Factor XII (FXII) is a coagulation protein that initiates surface-activation of the coagulation cascade in vitro. The protein's in vivo role, however, remains poorly defined. Factor XII deficiency, or Hageman trait, is a rare hereditary disorder that is not associated with bleeding, and wide variations in FXII activity (FXII:C) exist among healthy people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.04.053DOI Listing

Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1.

Exp Hematol 2019 Apr 22. Epub 2019 Apr 22.

Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

A subset of acute myeloid and lymphoid leukemia cases harbor a t(10;11)(p13;q14) translocation resulting in the CALM-AF10 fusion gene. Standard chemotherapeutic strategies are often ineffective in treating patients with CALM-AF10 fusions. Hence, there is an urgent need to identify molecular pathways dysregulated in CALM-AF10-positive leukemias which may lay the foundation for novel targeted therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2019.04.003DOI Listing
April 2019
1 Read

Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis-associated tumorigenesis.

Hum Pathol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252, -0374, Japan. Electronic address:

We focused on specific molecular events during the development of endometriosis-associated ovarian endometrioid carcinoma (OEmCa) and ovarian clear cell carcinoma (OCCCa). Alterations in β-catenin (encoded by CTNNB1) and microsatellite instability (MSI), as well as changes in the expression levels of HNF-1β and DNA mismatch repair (MMR) proteins were investigated in 50 OEmCas and 21 OCCCas with endometriotic lesions. Mutations of CTNNB1 were identified in 28 (56%) of the 50 OEmCa cases and 26 (41. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2019.04.001DOI Listing

A comprehensive analysis of corneal mRNA levels during sulfur mustard induced ocular late pathology in the rabbit model using RNA sequencing.

Exp Eye Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, 74100, Israel.

Exposure to sulfur mustard (SM) may result in severe ocular injuries. While some of the eyes show a clinical resolution of the injury (defined as clinically non-impaired), part of the eyes develop irreversible late ocular pathologies (defined as clinically impaired) that may lead to corneal blindness. Understanding the pathological mechanisms underlying the development of the late pathology may lead to improved treatment options. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835193018
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.04.011DOI Listing
April 2019
1 Read

An early adenocarcinoma collided with a pyloric gland adenoma in the gastric cardia.

Gastrointest Endosc 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2019.04.225DOI Listing

Enhanced Intrinsic Skin Aging in Nephropathic Cystinosis Assessed by High-Definition Optical Coherence Tomography.

J Invest Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatrics, University Hospitals Leuven, campus Gasthuisberg, Leuven, Belgium; Department of Development & Regeneration, KU Leuven, campus Gasthuisberg, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.03.1153DOI Listing

Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity.

Exp Neurol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pharmacology and Toxicology, University of Utah, USA; Interdepartmental Program in Neuroscience, University of Utah, USA. Electronic address:

The contribution of glial transporters to glutamate movement across the membrane has been identified as a potential target for anti-seizure therapies. Two such glutamate transporters, GLT-1 and system x, are expressed on glial cells, and modulation of their expression and function have been identified as a means by which seizures, neuronal injury, and gliosis can be reduced in models of brain injury. While GLT-1 is responsible for the majority of glutamate uptake in the brain, system x releases glutamate in the extracellular cleft in exchange for cystine and represents as such the major source of hippocampal extracellular glutamate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.04.010DOI Listing

Progressive Tinnitus Management at Two Veterans Affairs Medical Centers: Clinical Implementation With Modified Protocols.

Am J Audiol 2019 Apr;28(1S):162-173

VA Rehabilitation Research and Development National Center for Rehabilitative Auditory Research, VA Portland Health Care System, Oregon.

Purpose This is a description of the clinical implementation and outcomes of progressive tinnitus management (PTM) at 2 Veterans Affairs (VA) medical centers: Both programs modified the protocol originally described by PTM developers. Method Modifications at both sites were classified according to an evidence-based framework set forth by Stirman, Miller, Toder, and Calloway (2013) . The Iowa City VA PTM program clinicians made 2 modifications and the Asheville, North Carolina, VA PTM program clinicians made 6 modifications to the standard PTM protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1044/2018_AJA-TTR17-18-0040DOI Listing

WNK1 promotes renal tumor progression by activating TRPC6-NFAT pathway.

FASEB J 2019 Apr 25:fj201802019RR. Epub 2019 Apr 25.

Department of Physiology, Wonju College of Medicine, Yonsei University, Wonju, South Korea.

Deregulation of Ca signaling has been regarded as one of the key features of cancer progression. Lysine-deficient protein kinase 1 (WNK1), a major regulator of renal ion transport, regulates Ca signaling through stimulating the phosphatidylinositol 4-kinase IIIα (PI4KIIIα) to activate Gαq-coupled receptor/PLC-β signaling. However, the contribution of WNK1-mediated Ca signaling in the development of clear-cell renal-cell carcinoma (ccRCC) is yet unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201802019RRDOI Listing

Is Progression of Pulmonary Fibrosis Due to Ventilation-Induced Lung Injury?

Am J Respir Crit Care Med 2019 Apr 25. Epub 2019 Apr 25.

University of Colorado, School of Medicine, Department of Medicine, Aurora, Colorado, United States.

Many of the signaling pathways and growth factors involved with pulmonary fibrosis are well-described but little is known about why the fibroproliferative process progresses over time. Ventilation-induced lung injury occurs as a result of epithelial stress and strain from atelectrauma and volutrauma, respectively, both of which occur in the setting of alveolar collapse. We suggest that ventilation-induced lung injury may be a unifying process explaining perpetuation of the fibrosis on the basis that (a) alveolar collapse has been repeatedly described in patients with pulmonary fibrosis, thereby providing a setting in which ventilation-induced lung injury can occur, and (b) patients with pulmonary fibrosis, many of the risk factors and genetic variants associated with pulmonary fibrosis as well as most of models used to study pulmonary fibrosis are all associated with surfactant abnormalities and/or with alveolar type 2 cell injury that would predispose to surfactant abnormalities, thereby increasing surface tension and causing alveolar collapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201903-0497PPDOI Listing

Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer.

Cochrane Database Syst Rev 2019 Apr 25;4:CD012663. Epub 2019 Apr 25.

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, Room NA-1710, P.O. Box 2040, Rotterdam, Zuid-Holland, Netherlands, 3015 CE.

Background: Multiparametric magnetic resonance imaging (MRI), with or without MRI-targeted biopsy, is an alternative test to systematic transrectal ultrasonography-guided biopsy in men suspected of having prostate cancer. At present, evidence on which test to use is insufficient to inform detailed evidence-based decision-making.

Objectives: To determine the diagnostic accuracy of the index tests MRI only, MRI-targeted biopsy, the MRI pathway (MRI with or without MRI-targeted biopsy) and systematic biopsy as compared to template-guided biopsy as the reference standard in detecting clinically significant prostate cancer as the target condition, defined as International Society of Urological Pathology (ISUP) grade 2 or higher. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/14651858.CD012663.pub2
Publisher Site
http://dx.doi.org/10.1002/14651858.CD012663.pub2DOI Listing
April 2019
1 Read

Cell-cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses.

PLoS Pathog 2019 Apr 25;15(4):e1007675. Epub 2019 Apr 25.

Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient pteropine orthoreovirus and demonstrated that FAST protein was not essential for viral replication, but enhanced viral replication in the early phase of infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007675DOI Listing

Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts.

PLoS One 2019 25;14(4):e0215490. Epub 2019 Apr 25.

Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.

Induced pluripotent stem cell (iPSC)-technology is an important platform in medicine and disease modeling. Physiological degeneration and disease onset are common occurrences in the aging population. iPSCs could offer regenerative medical options for age-related degeneration and disease in the elderly. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215490PLOS

On the utilization of polygenic risk scores for therapeutic targeting.

Authors:
Greg Gibson

PLoS Genet 2019 Apr 25;15(4):e1008060. Epub 2019 Apr 25.

Center for Integrative Genomics and School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, United States of America.

The promise of personalized genomic medicine is that knowledge of a person's gene sequences and activity will facilitate more appropriate medical interventions, particularly drug prescriptions, to reduce the burden of disease. Early successes in oncology and pediatrics have affirmed the power of positive diagnosis and are mostly based on detection of one or a few mutations that drive the specific pathology. However, genetically more complex diseases require the development of polygenic risk scores (PRSs) that have variable accuracy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1008060DOI Listing

Craniosynostosis: A Reversible Pathology?

J Craniofac Surg 2019 Apr 18. Epub 2019 Apr 18.

Department of Plastic Surgery, Sahlgrenska University Hospital, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

The formation of the cranial sutures, in utero, occurs when the ossification of the skull bones reaches predestined positions around gestational week 15 to 20. Craniosynostosis, and the consequent skull shape deformities, is treated with surgery including osteotomies of the fused sutures. The occasional appearance of a new suture in the osteotomy lines has previously been described as sporadic events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SCS.0000000000005515DOI Listing

Major Structural Airway Pathologies of Patient Complaining Nasal Obstruction: Analysis of Frequency, Preoperative Complaints and Benefit from Surgery.

J Craniofac Surg 2019 Apr 20. Epub 2019 Apr 20.

Department of Plastic Surgery.

Introduction: Modern rhinoplasty has an aesthetic and a functional component that cannot be separated. Functional rhinoplasty generally concentrates on optimizing nasal airflow. Numerous techniques have been described for correction of each pathology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SCS.0000000000005554DOI Listing

Multiple primary melanoma with the Meyerson phenomenon in a young patient.

Melanoma Res 2019 Jun;29(3):325-327

Departments of Dermatology.

Meyerson phenomenon (MP), also called halo eczema or halo dermatitis, was first described in 1971 as a symmetric eczematous halo around acquired melanocytic nevi. Since then, cases of MP have been described in any kind of melanocytic nevi and also in non-melanocytic tumors. To the best of our knowledge, only four cases of melanoma associated with MP have been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CMR.0000000000000583DOI Listing

The cyclical hit model: how paligenosis might establish the mutational landscape in Barrett's esophagus and esophageal adenocarcinoma.

Curr Opin Gastroenterol 2019 Apr 22. Epub 2019 Apr 22.

Division of Gastroenterology, Department of Internal Medicine.

Purpose Of Review: In this review, we explore a paligenosis-based model to explain Barrett's esophagus development and progression: 'the cyclical hit model.'

Recent Findings: Genomic analyses have highlighted the high mutational burden of esophageal adenocarcinoma, Barrett's esophagus, and even normal esophageal epithelium. Somatic mutations in key genes including TP53 occur early in the neoplastic progression sequence of Barrett's esophagus, whereas chromosomal amplification resulting in oncogene activation occurs as a critical late event. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOG.0000000000000540DOI Listing

Tracheal Lymphoepithelioma-Like Carcinoma on FDG PET/CT.

Clin Nucl Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Pathology, Guangzhou First People's Hospital, Guangzhou, China.

Lymphoepithelioma-like carcinoma (LELC) in the trachea is an extremely rare disease. We present a case of a 64-year-old man with FDG-avid tracheal LELC on F-FDG PET/CT. Despite its rarity, LELC in the trachea should be considered as one of the possibilities in patients with a hypermetabolic mass in the trachea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002599DOI Listing

Diagnostic and Therapeutic Uptake of Intrathyroid Metastasis of Midgut Neuroendocrine Tumor on 68Ga-DOTANOC PET/CT and 177Lu-DOTATATE Imaging.

Clin Nucl Med 2019 Apr 19. Epub 2019 Apr 19.

Pathology Department, CHU Toulouse, Toulouse, France.

A 58-year-old woman with 5-year history of grade 1 progressive metastatic intestinal neuroendocrine tumor with metachronous liver metastases initially treated by surgery and liver embolization underwent Ga-DOTANOC PET/CT before Lu-DOTATATE therapy. Ga-DOTANOC PET/CT revealed increased uptake in several liver metastases and right iliac lymph nodes, consistent with radiopeptide therapy, including a hypodense isthmic thyroid nodule. Fine needle ultrasound-guided biopsy of the thyroid nodule was realized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002586DOI Listing
April 2019
1 Read

FDG PET/CT Demonstrated Precursor B-cell Lymphoblastic Lymphoma in a Pediatric Patient With Hemophilia B.

Clin Nucl Med 2019 Apr 19. Epub 2019 Apr 19.

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, 95 Yong An Road, Xi Cheng District, Beijing 100050, China.

A 4-year-old boy with history of hemophilia B presented with increasingly enlarged scalp masses. Although they were initially thought as hematomas, unresponsiveness to the therapy lead to suspicion of malignancy, which prompted FDG PET/CT. The FDG PET/CT images demonstrated increased FDG uptake in the scalp masses and cervical lymph nodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002582DOI Listing
April 2019
1 Read

Ovarian Teratomas in Women With Anti-N-methyl-D-Aspartate Receptor Encephalitis: Topography and Composition of Immune Cell and Neuroglial Populations is Compatible With an Autoimmune Mechanism of Disease.

Am J Surg Pathol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology, University of California San Francisco, San Francisco, CA.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune syndrome in young women that is often accompanied by an ovarian teratoma (NMDAR-E teratoma). A prevailing theory implicates that the generation of autoantibodies to NMDAR on neurons in the central nervous system is triggered by neuroglial tissue in the associated teratoma. The histopathology of NMDAR-E teratomas has not been fully elucidated but limited studies have focused on alterations in neuroglial tissues and immune cell populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001249DOI Listing

ALK Expression in Angiomatoid Fibrous Histiocytoma: Confirmation of the Findings of Cheah et al.

Am J Surg Pathol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001263DOI Listing

Mucoepidermoid Carcinoma: A Comparison of Histologic Grading Systems and Relationship to MAML2 Rearrangement and Prognosis.

Am J Surg Pathol 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery, Section of Otolaryngology Head and Neck Surgery, The University of Chicago Medicine, Chicago, IL.

Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy, but categorization is complicated by variability in grading systems and uncertain prognostic significance of MAML2 rearrangement. The aims of this study were to determine the prognostic significance of MEC grading systems and MAML2 rearrangement status. Fifty-three carcinomas originally diagnosed as MEC (45 primary; 8 recurrent) of major and minor salivary glands were graded according to modified Healey, Brandwein, AFIP, and Katabi systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001252DOI Listing

SMARCA4 Loss is Very Rare in Thoracic Mesothelioma.

Am J Surg Pathol 2019 Apr 23. Epub 2019 Apr 23.

Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research, St Leonards.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001262DOI Listing

Comprehensive Molecular Characterization of Adamantinoma and OFD-like Adamantinoma Bone Tumors.

Am J Surg Pathol 2019 Apr 23. Epub 2019 Apr 23.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham.

Adamantinoma and osteofibrous dysplasia (OFD)-like adamantinoma are rare primary bone tumors that are predominantly confined to the tibia. These 2 entities show similarities in location, histology, and radiologic appearance; however, adamantinoma is malignant and therefore differentiating between these bone tumors is essential for optimal patient care. To elucidate their genomic and transcriptomic alteration profiles and expand their etiological mechanisms, whole exome sequencing (WES) and RNA sequencing (RNA-Seq) were conducted on adamantinoma and OFD-like adamantinoma tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001251DOI Listing

Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women.

AIDS 2019 Apr 22. Epub 2019 Apr 22.

Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA.

Background: Antiretroviral treatment (ART) adherence is often suboptimal in the perinatal period. We measured hair tenofovir (TFV) concentrations as a metric of adherence in postpartum women to understand patterns and predictors of adherence throughout this critical period. Additionally, we examined the association between hair TFV concentrations and virologic outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000002237DOI Listing
April 2019
1 Read

Buccal Myomucosal Flap Reconstruction After Resection of Palatal Mucoepidermoid Carcinoma.

Ann Plast Surg 2019 Apr 18. Epub 2019 Apr 18.

From the Division of Plastic Surgery, Department, of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.

Salivary gland tumors are rare, constituting approximately 0.5% of pediatric malignancies, yet account for over 50% of malignant salivary gland neoplasms, of which a majority are mucoepidermoid carcinomas (MECs). We present a case of MEC involving the palatal minor salivary gland of an adolescent patient successfully reconstructed using buccal myomucosal flap. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SAP.0000000000001949DOI Listing

Which Fat Processing Can Achieve Optimal Transplantation in Patients With Insufficient Fat Resource?

Ann Plast Surg 2019 Apr 22. Epub 2019 Apr 22.

From the Breast Plastic and Reconstructive Surgery Center, and Department of Pathology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China.

Background: Autologous fat transfer has been widely used in breast augment surgery. The breast fat graft is different form facial, it needs megavolume grafts. However, most Asian women are thin, who often encounter the fat resource insufficiency during breast augmentation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SAP.0000000000001852DOI Listing
April 2019
1 Read

Acral Lentiginous Melanomas Harbour Intratumor Heterogeneity in BRAF Exon 15, With Mutations Distinct From V600E/V600K.

Am J Dermatopathol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, Universidade Federal de São Paulo, São Paulo, Brazil.

The choice of appropriate therapeutic strategies may be influenced by intratumor heterogeneity and makes cancer treatment considerably more challenging. We aimed to evaluate the heterogeneity of BRAF exon 15 mutations in different areas of acral lentiginous melanoma (ALM). The entire exon 15 was sequenced in 4 different areas of paraffin-embedded samples from 26 patients with ALM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001418DOI Listing

Extracorporeal shock wave therapy immediately affects Achilles tendon structure and widespread pressure pain thresholds in healthy people: a repeated-measures observational study.

Am J Phys Med Rehabil 2019 Apr 22. Epub 2019 Apr 22.

La Trobe Sport & Exercise Medicine Research Centre, La Trobe University, Bundoora VIC 3086, Australia.

Objectives: Extracorporeal shockwave therapy (ESWT) is a common clinical treatment for tendinopathy, yet negative effects on tendon structure have been shown in animal studies. This study aimed to investigate the effect of ESWT in healthy participants (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PHM.0000000000001203DOI Listing

New Observations Allowing the Differentiation of Late Asexual Stages of from Developing Microgamonts in the Intestines of Experimentally Infected Dogs.

J Parasitol 2019 Apr;105(2):345-350

2   Department of Biomedical Science and Pathology, Virginia Maryland College of Veterinary Medicine, Center for One Health Research, Virginia Tech, 1410 Prices Fork Road, Blacksburg, Virginia 24061.

The coccidian parasite (syn. ) can cause clinical disease in dogs. Three generations of meronts are reported to occur in the small intestine of experimentally infected dogs before gametogony and oocyst formation. Read More

View Article

Download full-text PDF

Source

Readability of Individuals With Disabilities Education Act Part B Procedural Safeguards: An Update.

Lang Speech Hear Serv Sch 2019 Apr 25:1-12. Epub 2019 Apr 25.

Department of Audiology and Speech Pathology, University of Arkansas at Little Rock.

Purpose The purpose of this study was to analyze the readability of Individuals with Disabilities Education Act (IDEA) Part B procedural safeguard documents, as distributed by each of the 50 U.S. states. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1044/2018_LSHSS-18-0057DOI Listing
  • Page 1 of 66324