3,250,460 results match your criteria Pathology Case Reviews [Journal]


Cranberry juice decreases disease activity in women with rheumatoid arthritis.

Nutrition 2018 Oct 10;60:112-117. Epub 2018 Oct 10.

Department of Internal Medicine,University of Londrina, Londrina, Paraná, Brazil. Electronic address:

Objectives: Studies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in patients with rheumatoid arthritis (RA). The aim of this study was to verify the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA.

Methods: A prospective study was conducted with 41 women diagnosed with RA. Read More

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October 2018
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Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis.

Environ Int 2018 Dec 12;123:301-309. Epub 2018 Dec 12.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. Read More

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December 2018

Polyphasic characterization of Epicoccum sorghinum: A tenuazonic acid producer isolated from sorghum grain.

Int J Food Microbiol 2018 Dec 7;292:1-7. Epub 2018 Dec 7.

Laboratory of Mycotoxins and Toxigenic Fungi, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

Epicoccum sorghinum isolates from sorghum grain grown in Brazil were characterized using a polyphasic approach based on morphological, genetic and physiologic features. A considerable intraspecific variability was observed. The phylogenetic analysis showed that the 53 isolates studied formed four distinct clades, and their morphological features revealed a high variability in culture. Read More

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December 2018
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Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity.

Mult Scler Relat Disord 2018 Dec 5;28:34-43. Epub 2018 Dec 5.

Neuroimmunological Diseases Section (NDS), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5N248, 10 Center Drive, MSC1444, Bethesda, MD 20892, United States. Electronic address:

Background: Once multiple sclerosis (MS) reaches the progressive stage, immunomodulatory treatments have limited efficacy. This suggests that processes other than activation of innate immunity may at least partially underlie disability progression during late stages of MS. Pathology identified these alternative processes as aberrant activation of astrocytes and microglia, and subsequent degeneration of oligodendrocytes and neurons. Read More

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December 2018

Autoimmune encephalitis following alemtuzumab treatment of multiple sclerosis.

Mult Scler Relat Disord 2018 Dec 3;28:31-33. Epub 2018 Dec 3.

Department of Neurology, St Vincent's Hospital, 390 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia.

Secondary autoimmune disorders are a recognised complication of alemtuzumab treatment for multiple sclerosis. We report a case of autoimmune encephalitis manifesting as a polymorphic epilepsia partialis continua / status epilepticus seven months after the second course of alemtuzumab in a patient with previous autoimmune hypothyroidism and immune thrombocytopenic purpura. An MRI revealed multifocal cortical abnormalities and neuronal loss was evident on biopsy. Read More

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December 2018
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Molecular Study of Resistance of Staphylococcus aureus to Antiseptic Quaternary Ammonium Sulfate.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Clinical Pathology, Helwan Faculty of Medicine, Egypt.

Objective: The goals of the present study were to i.determine the prevalence of qac and smr genes in clinical isolates of S.aureus from hospital acquired infections ii. Read More

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December 2018

A case of completely isolated advanced enteric duplication cyst cancer performed partial pancreatectomy.

Int J Surg Case Rep 2018 Nov 27;54:83-86. Epub 2018 Nov 27.

Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Nishiiwata 3-4-5, Higashiosaka, Osaka, 567-8588, Japan.

Introduction: Enteric duplication cysts are rare and, in addition, isolated enteric duplication cysts are lower morbidity prevalence rate. These cysts lack a connection to the gastrointestinal tract or the adjacent mesenteric vasculature and have only been reported in 10 case reports. In these reports, only two reports were cases with malignant transformation. Read More

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November 2018

Early response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Laboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil. Electronic address:

Manifestations of local tissue damage, such as hemorrhage and myonecrosis, are among the most dramatic effects of envenomation by viperid snakes. Snake venom metalloproteinases (SVMPs) of the P-III class are main players of the hemorrhagic effect due to their activities in promoting blood vessel disruption. Hemorrhagic Factor 3 (HF3), a P-III class SVMP from Bothrops jararaca, shows a minimum hemorrhagic dose of 240 fmol on rabbit skin. Read More

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December 2018
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Genetic susceptibility to Tuberculosis: Interaction between HLA-DQA1 and age of onset.

Infect Genet Evol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China.

Several genome-wide association studies (GWAS) identified new single nucleotide polymorphisms (SNPs) with susceptibility to Tuberculosis (TB). However, many of them were not replicated across ethnic groups. The cause of this phenomenon of genetic heterogeneity is uncertain. Read More

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December 2018
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Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology and Biotechnology "Charles Darwin", La Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.; Pasteur Institute-Cenci Bolognetti Foundation, Viale Regina Elena, 291, 00100 Rome, Italy.. Electronic address:

Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle interactions, we discovered that Erg27p resides mainly in Lipid Droplets (LDs) in respiratory competent cells, while in absence of respiration, is found mostly in the ER. Read More

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December 2018

Epidemiology and etiology of diarrhea in UK military personnel serving on the United Nations Mission in South Sudan in 2017: A prospective cohort study.

Travel Med Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Academic Department of Military Medicine, Medical Directorate, Defence Medical Services, Birmingham, UK.

Background: . Diarrhea is a well-established problem in travellers, with military personnel at especially high risk. This study aimed to characterise the spectrum of pathogens causing diarrhea in UK military personnel in South Sudan, and assess the utility of culture-independent testing for etiology and antimicrobial resistance in a logistically challenging and austere environment. Read More

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December 2018

Synchronous occurrence of multiple distinct jaw lesions in Simpson-Golabi-Behmel Syndrome: A case report.

J Stomatol Oral Maxillofac Surg 2018 Dec 12. Epub 2018 Dec 12.

Associate Professor, Department of Pathology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.

Simpson-Golabi-Behmel Syndrome (SGBS) is an X-linked overgrowth syndrome characterized by pre- and postnatal overgrowth, typical facial appearance and multiple visceral, skeletal, and neurological anomalies. There is only few information in the current literature, on clinical and particularly dentofacial findings due to recent identification of the syndrome and its clinical overlap with other overgrowth syndromes. The aim of this case report is to present dentofacial findings in a 16-year-old boy who had been diagnosed with SGBS. Read More

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December 2018

Electrophysiological and behavioral measures of some speech contrasts in varied attention and noise.

Hear Res 2018 Dec 6;373:1-9. Epub 2018 Dec 6.

Lund University Department of Psychology, Paradisgatan 5, Lund, 22100, Sweden. Electronic address:

This paper investigates the salience of speech contrasts in noise, in relation to how listening attention affects scalp-recorded cortical responses. The contrasts that were examined with consonant-vowel syllables, were place of articulation, vowel length and voice-onset time (VOT) and our analysis focuses on the correspondence between the effect of attention on the electrophysiology and the decrement in behavioral results when noise was added to the stimuli. Normal-hearing subjects (n = 20) performed closed-set syllable identification in no noise, 0, 4 and 8 dB signal-noise ratio (SNR). Read More

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December 2018

Response to the Letter to the Editor - Necessity of accurate identification of Elizabethkingia species.

Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

In addition to Bruker, the latest version of the Vitek MS IVD database-IVD V3.2-was released by bioMérieux in May 2018. The database includes spectra for E. Read More

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December 2018

Alpha-synuclein is highly prone to distribution in the hippocampus and midbrain in tree shrews, and its fibrils seed Lewy body-like pathology in primary neurons.

Exp Gerontol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China; Medical Primate Research Center & Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100005, China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Diseases, Kunming 650118, China. Electronic address:

The Chinese tree shrew (TS) has many unique advantages that make it suitable for use as an experimental animal model for human disease including moderate body size, low cost of feeding, short reproductive cycle and lifespan, and close phylogenetic relationship to primates. Our previous studies have shown that TS treated with the mitochondrial inhibitor MPTP displayed classic Parkinsonian symptoms. Additionally, the structure of TS alpha-synuclein (α-syn) is highly homologous to that found in humans. Read More

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December 2018

Enhanced remedial effects for vitamin D and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia. Electronic address:

Background: Lead (Pb) is a toxic heavy metal and nephropathy is common with chronic exposure. Although vitamin D (VD) and calcium (Ca) showed promising protections, their co-administration was not previously investigated in Pb nephrotoxicity. This study measured the potential interactions and remedial effects of VD and/or Ca on established Pb nephropathy. Read More

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December 2018

Defective repair capacity of variant proteins of the DNA glycosylase NTHL1 for 5-hydroxyuracil, an oxidation product of cytosine.

Free Radic Biol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

The NTHL1 gene encodes DNA glycosylase, which is involved in base excision repair, and biallelic mutations of this gene result in NTHL1-associated polyposis (NAP), a hereditary disease characterized by colorectal polyposis and multiple types of carcinomas. However, no proper functional characterization of variant NTHL1 proteins has been done so far. Herein, we report functional evaluation of variant NTHL1 proteins to aid in the accurate diagnosis of NAP. Read More

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December 2018

Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Oncological Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, PR China; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China. Electronic address:

Ethnopharmacological Relevance: The development of a multidrug-resistant (MDR) phenotype is a main obstacle to the successful treatment of breast cancer. Saponins of several herbs are considered as promising candidates for drug resistance treatment. We extracted Paris saponin VII (PS VII) from Trillium tschonoskii Maxim. Read More

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December 2018
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Anthriscus sylvestris root extract reduces allergic lung inflammation by regulating interferon regulatory factor 4-mediated Th2 cell activation.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Korea; Department of Pathology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do, 26339, Korea. Electronic address:

Ethnopharmacological Relevance: Anthriscus sylvestris L. Hoffmann (AS) is a perennial plant that grows in Asia and Eastern Europe. Its dried root is used to treat conditions such as asthma, bronchitis, and cough. Read More

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December 2018
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Long-term outcomes for patients with desmoid fibromatosis treated with radiation therapy: a 10-year update and re-evaluation of the role of radiation therapy for younger patients.

Int J Radiat Oncol Biol Phys 2018 Dec 12. Epub 2018 Dec 12.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objective: To update our experience with long-term outcomes in patients with desmoid fibromatosis treated with radiation therapy (RT) and to characterize factors associated with increased risk of local recurrence.

Methods: We reviewed the records of 209 consecutive patients with desmoid fibromatosis treated with RT, either alone or as combined modality therapy (CMT) with surgery, at our institution from 1965 to 2015.

Results: Median follow-up time was 98 months (range, 1-509 months). Read More

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December 2018

Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group than PI-RADS Score in Multi-Parametric Prostate MRI-Ultrasound Fusion Targeted Biopsies.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Yale School of Medicine, New Haven, CT. Electronic address:

Objective: To assess the association between Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) score, the Decipher score and histologic grade of carcinoma in biopsy tissue among low- to intermediate-risk prostate cancer patients.

Methods: MRI-ultrasound targeted biopsy of regions of interest and concurrent 12-core systematic biopsy was performed on men with Gleason grade group (GG) 1 and 2. We compared Decipher score with PI-RADS scores and biopsy Gleason GG. Read More

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December 2018

Using Aorta-Lesion-Attenuation Difference (ALAD) on Preoperative Contrast-Enhanced CT Scan to Differentiate between Malignant and Benign Renal Tumors.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Urology, University of Florida College of Medicine, Gainesville, FL.

Objectives: To evaluate the ability of Aorta-Lesion-Attenuation-Difference (ALAD) to differentiate malignant renal tumors from renal oncocytomas.

Methods: A retrospective review of preoperative CT scans and surgical pathology was performed on patients undergoing partial nephrectomy for small, solid renal masses. ALAD was calculated by measuring the difference in Hounsfield units (HU) between the aorta and the lesion of interest on the same image slice on preoperative CT scan. Read More

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December 2018

Cardio-omentopexy Reduces Cardiac Fibrosis and Heart Failure after Experimental Pressure Overload.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. Electronic address:

Background: The pedicled greater omentum has been shown to offer benefit in ischemic heart disease for both animal models and human patients. The impact of cardio-omentopexy in a pressure overload model of left ventricular hypertrophy (LVH) is unknown.

Methods: LVH was created in rats by banding the ascending aorta after right thoracotomy (n=23). Read More

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December 2018

Ki-67 labeling index in glioblastoma; does it really matter?

Hematol Oncol Stem Cell Ther 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Objective/background: Glioblastoma (GB) is the most common primary malignant brain tumor in adults. Ki-67 is a nonhistone nuclear protein that is expressed by cells entering the mitotic cycle and is associated with the transcription of ribosomal RNA (rRNA). In gliomas, the extent of expression of Ki-67 is roughly proportional to the histologic grade. Read More

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December 2018

Motivational interviewing increases autopsy rates.

Swiss Med Wkly 2018 Nov 2;148:w14679. Epub 2018 Dec 2.

Department of Medicine, Kantonsspital Winterthur, Switzerland.

Background: Autopsies are a crucial source of medical knowledge. Unfortunately, autopsy rates have decreased markedly in Switzerland and many other countries. Communication between clinicians and the deceased’s sceptical relatives is crucial to obtain autopsy permission. Read More

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November 2018

Improving the quality and workflow of bacterial genome sequencing and analysis: paving the way for a Switzerland-wide molecular epidemiological surveillance platform.

Swiss Med Wkly 2018 Dec 15;148:w14693. Epub 2018 Dec 15.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Facing multidrug resistant (MDR) bacterial pathogens is one of the most important challenges for our society. The spread of highly virulent and resistant pathogens can be described using molecular typing technologies; in particular, whole genome sequencing (WGS) data can be used for molecular typing purposes with high resolution. WGS data analysis can explain the spatiotemporal patterns of pathogen transmission. Read More

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December 2018
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Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. Read More

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December 2018
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The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Background: Electrochemotherapy is an established treatment for cutaneous tumors. This study aimed at determining efficacy of electrochemotherapy in recurrent head and neck cancer.

Methods: Phase II clinical trial in patients with recurrent head and neck carcinomas with no curative treatment options. Read More

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December 2018

Smoking and papillomavirus DNA in patients with p16-positive N3 oropharyngeal squamous cell carcinoma.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Head and Neck Oncology, Gustave Roussy Institute, Université Paris-Saclay, Villejuif, France.

Background: We investigated the survival of patients with a p16-positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics.

Methods: We retrospectively reviewed the data of patients treated at our Cancer Center for a p16-positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression-free survival (PFS). Read More

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December 2018
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Radiographic nodal prognostic factors in stage I HPV-related oropharyngeal squamous cell carcinoma.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Radiation Oncology, Southern California Permanente Medical Group, Los Angeles, California.

Background: The updated AJCC Cancer Staging Manual groups all p16-positive oropharyngeal squamous cell carcinoma (OPSCC) with unilateral nodal involvement within 6 cm into the new clinical N1 classification, consolidating a heterogeneous group of disease with varying radiographic findings.

Methods: A central radiological review was conducted identifying 233 patients with stage I node-positive (cT1-2N1) disease who underwent definitive concurrent chemoradiation. Factors evaluated included lymph node size, low-neck lymphadenopathy, retropharyngeal lymphadenopathy, overt radiographic extracapsular extension, and matted lymphadenopathy. Read More

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December 2018
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Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.

Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.

Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. Read More

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December 2018

Regression of human immunodeficiency virus-associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Oral Pathology, Department of Stomatology, University of Sao Paulo School of Dentistry, Sao Paulo, Brazil.

Background: Kaposi's sarcoma (KS) is the most prevalent malignant neoplasia in human immunodeficiency virus positive (HIV+) patients for which the primary mode of management was chemotherapy.

Methods: We have presented the case of a newly diagnosed HIV+ male patient who was diagnosed with a pedunculated nodule in the anterior region of the hard palate, measuring 3.5 cm in diameter and with 2 months of evolution. Read More

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December 2018
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Skin tape stripping: which layers of the epidermis are removed?

Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.

The National Allergy Research Centre, Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.

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December 2018
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Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder.

Acta Psychiatr Scand 2018 Dec 15. Epub 2018 Dec 15.

Institute of Clinical Medicine, University of Oslo, Norway.

Objective: The relationship between borderline personality disorder (BPD) and bipolar II disorder (BIP-II) is disputed but understudied. Here, we investigated brain glucose metabolism in these patient groups and healthy control subjects (HCs).

Methods: Sixty-five subjects, 22 BPD (19 females); 22 BIP-II (17 females); 21 HC (14 females) were examined using 2-deoxy-2[18F]-fluoro-d-glucose Positron-Emission Tomography (PET) scanning. Read More

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December 2018

Cytohistological correlation, immunohistochemistry and Murine Double Minute Clone 2 amplification of pulmonary artery intimal sarcoma: A case report with review of literature.

Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.

Pulmonary artery intimal sarcoma is a rare aggressive intraluminal tumor often misdiagnosed as acute or chronic pulmonary thromboembolism due to its clinical presentation and radiological findings. Thus early diagnosis is very crucial and may improve patient outcome. There is limited literature on diagnosis of pulmonary artery sarcoma by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Read More

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December 2018

Pleomorphic and atypical multinucleated giant cells in solid pseudopapillary neoplasm of pancreas: A diagnostic pitfall in cytology and a review of the literature.

Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio.

Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low-grade malignancy typically occurring in young women. Occasionally, these neoplasms present with pleomorphic to atypical multinucleated giant tumor cells which may mimic high-grade malignancy. Our patient is a 25-year-old male who presented with one year of intermittent epigastric pain. Read More

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December 2018

A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer.

Cancer Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

Background: Prognosis among patients with differentiated thyroid cancer is widely variable. Better understanding of biologic subtypes is necessary to stratify patients and improve outcomes.

Methods: In patients diagnosed with classic histology papillary thyroid cancer treated from 1973 to 2009, BRAF V600E mutation status was determined on surgical tumor specimens by restriction fragment length polymorphism analysis. Read More

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December 2018

Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Health Sciences, Department of Oral Pathology and Oral Biology, School of Dentistry, University of Pretoria, Pretoria, South Africa.

Background: Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different sections of the same HPV negative tumor on the floor of mouth in a patient with history of prolonged smoking.

Methods: Histological examination, presence of HPV infection and OncoScan analysis of DNA extracted from two well-defined areas with different p16 expression profiles were performed. Read More

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December 2018

Genetically engineered animal models of Parkinson's disease: from worm to rodent.

Eur J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Functional Chemistry, IRCCS Mondino Foundation, Pavia, 27100, Italy.

Parkinson's disease (PD) is a progressive neurological disorder characterised by aberrant accumulation of insoluble proteins, including alpha-synuclein, and a loss of dopaminergic neurons in the substantia nigra. The extended neurodegeneration leads to a drop of striatal dopamine levels, responsible for disabling motor and non-motor impairments. Although the causes of the disease remain unclear, it is well accepted among the scientific community that the disorder may also have a genetic component. Read More

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December 2018
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Histopathologic discrepancies between endoscopic forceps biopsy and endoscopic resection specimens in superficial esophageal squamous neoplasms.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Korea.

Background And Aims: Endoscopic forceps biopsy results that reflect the final pathologic results of an entire lesion are essential for making accurate diagnoses and appropriate therapeutic decisions for patients with superficial esophageal squamous neoplasms (SESNs). This study investigated the histopathologic discrepancies between endoscopic forceps biopsy and endoscopic resection specimens to elucidate the factors contributing to such discrepancies.

Methods: This retrospective observational study involved 77 patients (84 lesions) who underwent endoscopic resections for SESNs, between January 2005 and August 2017, at the Pusan National University Hospital. Read More

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December 2018

EFFECT OF TIME OF THE DAY AND SPECIALITY ON POLYP DETECTION RATES IN AUSTRALIA.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, the University of Adelaide, Adelaide, South Australia, Australia.

Background And Aim: Adenoma detection rate (ADR) is an important quality metric in colonoscopy. However, there is conflicting evidence around factors that influence ADR. This study aims to investigate the effect of time of day and endoscopist background on ADR and sessile serrated adenoma/polyp detection rate (SSA/P-DR) for screening colonoscopies. Read More

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December 2018
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Recurrent neutrophilic dermatosis of the face.

Clin Exp Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Farhat Hached University Hospital, Avenue Ibn Jazzar, 4002, Sousse, Tunisia.

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December 2018

PUMA induction mediates acetaminophen-induced necrosis and liver injury.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA.

Acetaminophen (APAP) overdose is one of the leading causes of hepatotoxicity and acute liver failure in the United States. Accumulating evidence suggests that hepatocyte necrosis plays a critical role in APAP-induced liver injury. However, the mechanisms of APAP-induced necrosis and liver injury are not fully understood. Read More

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December 2018

NRAS Q61R and BRAF G466A Mutations in Atypical Melanocytic Lesions Newly Arising in Advanced Melanoma Patients Treated with Vemurafenib.

J Cutan Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations.

Methods: We identified three severely dysplastic nevi, one atypical intraepidermal melanocytic proliferation, and four melanoma in situ lesions, newly arising in four patients undergoing treatment with vemurafenib. To characterize mutations in these atypical melanocytic lesions, we used a custom iPlex panel detecting 74 mutations in 13 genes known to play a role in melanoma pathogenesis. Read More

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December 2018

Lichen planus: altered AIM2 and NLRP1 expression in skin lesions and defective activation in peripheral blood mononuclear cells.

Clin Exp Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Investigation in Medicine, LIM-56, Department of Dermatology, Tropical Medicine Institute of São Paulo, University of São Paulo Medical School, São Paulo, Brazil.

Background: Lichen planus (LP) is an inflammatory skin disease with unknown aetiology. Activation by pathogen-associated molecular patterns or environmental stimuli may activate some components of inflammasomes that contribute to the inflammatory process in LP lesions.

Aim: To characterize the inflammasomes in skin lesions and peripheral blood mononuclear cells (PBMCs) of patients with LP under Toll-like receptor (TLR) activation. Read More

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December 2018
3 Reads

Double-positive CD8/CD4 primary cutaneous acral T-cell lymphoma.

J Cutan Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Venerology and Allergology, University Medical Center Graz, Austria.

Primary cutaneous acral CD8 T-cell lymphoma (acral CD8 TCL) is a rare, clinically indolent lymphoma that is classified as provisional entity in the 2016 revision of the WHO classification of tumors of hematopoietic and lymphoid tissue (1-3). This article is protected by copyright. All rights reserved. Read More

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December 2018

Cortical interlaminar astrocytes across the therian mammal radiation.

J Comp Neurol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA.

Interlaminar astrocytes (ILA) in the cerebral cortex possess a soma in layer I and extend an interlaminar process that runs perpendicular to the pia into deeper cortical layers. We examined cerebral cortex from 46 species that encompassed most orders of therian mammalians, including 22 primate species. We described two distinct cell types with interlaminar processes that have been referred to as ILA, that we termed pial ILA and supial ILA. Read More

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December 2018
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CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

Cancer stem cells (CSCs) exist in colon cancer and exhibit characteristics of stem cells which are due to lineages of tissues where they arise. Epithelial to mesenchymal transition (EMT)-undergoing cancer cells display CSC properties and therapeutic resistance. Cancer and stromal cells comprise of a tumor microenvironment. Read More

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December 2018

Downregulation of long noncoding RNA DGCR5 contributes to the proliferation, migration, and invasion of cervical cancer by activating Wnt signaling pathway.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Huai'an Maternal and Child Health Care Center of Jiangsu Province Affiliated Hospital of Yangzhou University, Huai'an, China.

Accumulating research works have reported that long noncoding RNAs (lncRNAs) are involved in various cancers, including cervical cancer. LncRNA DGCR5 has been identified in many cancers. However, the biological role of DGCR5 in cervical cancer remains barely known. Read More

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December 2018

Periventricular Microglial Cells Interact with Dividing Precursor Cells in the Nonhuman Primate and Rodent Prenatal Cerebral Cortex.

J Comp Neurol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, School of Medicine, UC Davis, Davis, CA.

Cortical proliferative zones have been studied for over 100 years, yet recent data has revealed that microglial cells constitute a sizeable proportion of ventricular zone cells during late stages of cortical neurogenesis. Microglia begin colonizing the forebrain after neural tube closure and during later stages of neurogenesis populate regions of the developing cortex that include the proliferative zones. We previously showed that microglia regulate the production of cortical cells by phagocytosing neural precursor cells (NPCs), but how microglia interact with NPCs remains poorly understood. Read More

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December 2018
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