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Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):75-77

Department of Dermatology and Venereology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Transit metastases include metastatic foci of the skin and subcutaneous tissue located between the tumor and the nearest regional lymph node. Although transit metastases have been described for malignant melanoma, some cases of transit metastases have also been reported among primary cutaneous non-melanoma cancers. Treatment of patients with in-transit squamous cell carcinoma (SCC) is a multimodal approach for advanced staging imaging and therapy, including Mohs micrographic surgery, adjuvant radiation, and possibly sentinel lymph node biopsy and immunotherapy or chemotherapy. Read More

J Pak Med Assoc 2022 Jun;72(6):1092-1096

Department of Pathology, Ziauddin University, Karachi, Pakistan.

Objective: To detect polymorphisms of CYP1A1, GSTM1 and GSTT1 gene loci among various tobacco-consuming ethnicities in an urban centre, and to relate these with susceptibility to oral cancer.

Methods: The cross-sectional, case-control study was conducted at Ziauddin University, Karachi, and the Dow University of Health Sciences, Karachi, from 2011 to 2016, and comprised patients having oral squamous cell carcinoma in group A, with oral precancerous lesions in group B, and tobacco habit-matched controls in group C. Routine histopathology was followed by molecular analysis through polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism techniques. Read More

BMC Cancer 2022 Jun 24;22(1):697. Epub 2022 Jun 24.

Department of Surgery, Division of Colorectal Surgery, University of Illinois at Chicago, Chicago, IL, USA.

Background: Anal squamous cell carcinoma (SCC) generally carries a favorable prognosis, as most tumors are highly sensitive to standard of care chemoradiation. However, outcomes are poor for the 20-30% of patients who are refractory to this approach, and many will require additional invasive procedures with no guarantee of disease resolution.

Methods: To identify the patients who are unlikely to respond to the current standard of care chemoradiation protocol, we explored a variety of objective clinical findings as a potential predictor of treatment failure and/or mortality in a single center retrospective study of 42 patients with anal SCC. Read More

BMC Cancer 2022 Jun 24;22(1):699. Epub 2022 Jun 24.

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abenoku, Osaka, 545-8585, Japan.

Background: Tertiary lymphoid structures (TLSs) have been reported to be involved in immune responses in many carcinomas. This study investigated the significance of TLSs in esophageal squamous cell carcinoma, focusing on TLS maturation.  METHODS: The relationships of TLSs with clinicopathological features of 236 patients who underwent curative surgery for stage 0-IV esophageal squamous cell carcinoma were investigated. Read More

J Cancer Res Clin Oncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: PSMD14 is an essential protein for proteasomal degradation. Inhibition of this protein disrupts homeostasis and inhibits cancer cell viability. Overexpression of PSMD14 was associated with advanced cancer characteristics and a worse prognosis in various carcinomas. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun 17;51:602-607. Epub 2022 Jun 17.

Department of Pathology, the Seventh Medical Center, PLA General Hospital, Beijing 100700, China.

To investigate the expression of PD-L1, CD4, CD8 and CXCL-13 in cervical carcinoma, and their clinicopathological significance was analyzed. A total of 77 patients with cervical carcinoma in the Seventh Medical Center, PLA General Hospital from January 2019 to December 2021 were included. All patients received radical surgical resection in the Seventh Medical Center of Chinese PLA General Hospital. Read More

Oral Oncol 2022 Jun 21;132:105978. Epub 2022 Jun 21.

Department of Otorhinolaryngology, Head and Neck Surgery, RWTH University of Aachen, Germany. Electronic address:

Introduction: Confocal laser endomicroscopy (CLE) is an optical imaging technique that allows in vivo microscope-like images of the upper aerodigestive tract's mucosa in 1000-fold magnification. The assessment of morphological tissue characteristics for the correct differentiation between healthy and malignoma suspected mucosa requires strict evaluation criteria. This study aims to validate a score for oral cavity squamous cell carcinoma (OCSCC) diagnostic. Read More

J Cutan Pathol 2022 Jun 24. Epub 2022 Jun 24.

Renaissance School of Medicine at Stony Brook University.

An 83-year-old male with a history of both melanoma and non-melanoma skin cancers presented with a light pink non-ulcerated slightly raised 0.6 x 0.5 cm papule on his left lower extremity. Read More

J Contemp Dent Pract 2022 Feb 1;23(2):268-275. Epub 2022 Feb 1.

Dayanand Sagar University, Bengaluru, Karnataka, India.

Aim: To review the principles and application of Nanopore Sequencing Technology (NPST) in oral cancer.

Background: Oral cancer is a disease caused by aberrations in the genes. Substantial research at the genomic level is still required for in-depth understanding of the molecular mechanism in oral cancer. Read More

Afr J Lab Med 2022 12;11(1):1563. Epub 2022 May 12.

Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Background: Globally, women living with HIV have a higher risk of vulvar neoplasia than HIV-negative women. Vulvar neoplasia among women living with HIV has not previously been characterised in Zambia.

Objective: This study determined the clinical and pathologic features of vulvar neoplasia among women living with HIV at the University Teaching Hospital, Lusaka, Zambia. Read More

J Clin Med 2022 Jun 16;11(12). Epub 2022 Jun 16.

Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Background: Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide, leading to significant disease-associated social and financial burdens. The investigation of underlying mechanisms involved in carcinogenesis and tumor progression in OSCC might provide new therapeutic perspectives with an impact on disease control and patient survival. Our study aims to investigate the interrelation between metabolic processes, expressed through final catabolism products and clinicopathological characteristics in OSCC. Read More

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.

We describe a patient with both gastric adenocarcinoma and metastatic squamous cell carcinoma (SCC) of unknown primary site. The possibility of a single malignant clonal process as opposed to differing primaries was supported by the finding of both histologies exhibiting high microsatellite instability. Despite evidence of tumor microsatellite instability, the patient's disease process did not respond to immune checkpoint inhibition. Read More

Int J Mol Sci 2022 Jun 15;23(12). Epub 2022 Jun 15.

Department of Diagnostic Pathology, Graduate School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.

In recent years, the choice of immune checkpoint inhibitors (ICIs) as a treatment based on high expression of programmed death-ligand 1 (PD-L1) in lung cancers has been increasing in prevalence. The high expression of PD-L1 could be a predictor of ICI efficacy as well as high tumor mutation burden (TMB), which is determined using next-generation sequencing (NGS). However, a great deal of effort is required to perform NGS to determine TMB. Read More

Int J Mol Sci 2022 Jun 9;23(12). Epub 2022 Jun 9.

Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.

Cancer-associated fibroblasts (CAFs) and partial epithelial-mesenchymal transition (p-EMT) tumor cells are closed together and contribute to the tumor progression of oral squamous cell carcinoma (OSCC). In the present study, we deeply analyzed and integrated OSCC single-cell RNA sequencing datasets to define OSCC CAFs and p-EMT subpopulations. We highlighted the cell-cell interaction network of CAFs and p-EMT tumor cells and suggested biomarkers for the diagnosis and prognosis of OSCC during the metastasis condition. Read More

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Pathology, Saint Savvas Anticancer Hospital of Athens, 11522 Athens, Greece.

Microglandular adenosis is a non-lobulocentric haphazard proliferation of small round glands composed of a single layer of flat to cuboidal epithelial cells. The glandular structures lack a myoepithelial layer; however, they are surrounded by a basement membrane. Its clinical course is benign, when it is not associated with invasive carcinoma. Read More

Diagnostics (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.

The heterogeneous nuclear ribonucleoprotein D (hnRNPD) serves as a prognostic marker for oral squamous cell carcinoma (OSCC). We evaluated the diagnostic potential of hnRNPD to differentiate between OSCC and normal mucosa. Immunohistochemistry for hnRNPD and a routinely used diagnostic marker deltaNp63 (p40) was performed in 32 normal mucosae and 46 OSCC specimens. Read More

Cancers (Basel) 2022 Jun 20;14(12). Epub 2022 Jun 20.

German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.

(1) Background: Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who are biologically at high risk for the development of loco-regional recurrences after postoperative radiotherapy (PORT) but at intermediate risk according to clinical risk factors may benefit from additional concurrent chemotherapy. In this matched-pair study, we aimed to identify a corresponding predictive gene signature. (2) Methods: Gene expression analysis was performed on a multicenter retrospective cohort of 221 patients that were treated with postoperative radiochemotherapy (PORT-C) and 283 patients who were treated with PORT alone. Read More

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Department of Pathology, University of Helsinki and Helsinki University Hospital, P.O. Box 21, FI-00014 Helsinki, Finland.

Background: This study was carried out to observe the upregulation of the free β-subunit of human chorionic gonadotropin (hCGβ) and its prognostic significance in human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC).

Materials And Methods: A total of 90 patients with OPSCC treated with curative intent at the Helsinki University Hospital (HUS), Helsinki, Finland, during 2012-2016 were included. Serum samples were collected prospectively, and their hCGβ concentrations (S-hCGβ) were determined by an immunofluorometric assay. Read More

Biomedicines 2022 May 29;10(6). Epub 2022 May 29.

Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Background: A high platelet-lymphocyte ratio (PLR) is a marker of systemic inflammation and, together with the neutrophil-lymphocyte ratio (NLR), is associated with poor outcomes in several cancers. We investigated the prognostic value of PLR and other systemic inflammatory markers, such as NLR, systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), in oral squamous cell carcinoma (OSCC) patients undergoing surgical resection.

Methods: We derived PLR, NLR, SII, and SIRI from a retrospective chart review of 269 consecutive OSCC patients. Read More

PLoS One 2022 23;17(6):e0265465. Epub 2022 Jun 23.

Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Eukaryotic initiation factor 4E (eIF4E) and its phosphorylated form (p-eIF4E) play a crucial role in the protein synthesis, both are under regulation of eIF4E-binding protein 1 (4EBP1) and mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs). This study aims to explore the potential prognostic significance of p-4EBP1 and p-eIF4E in NSCLC patients. The expression of p-4EBP1 and p-eIF4E in NSCLC patients was detected by immunohistochemistry (IHC) staining in tissue microarrays (TMAs) containing 354 NSCLC and 53 non-cancerous lung tissues (Non-CLT). Read More

Curr Oncol 2022 Jun 15;29(6):4274-4284. Epub 2022 Jun 15.

Department of Radiotherapy/Oncology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Microenvironmental conditions control the entrance and thriving of cytotoxic lymphocytes in tumors, allowing or preventing immune-mediated cancer cell death. We investigated the role of tumor-infiltrating lymphocyte (TIL) density in the outcome of radiotherapy in a series of squamous cell head-neck tumors (HNSCC). Moreover, we assessed the link between markers of hypoxia and TIL density. Read More

Clin Transl Med 2022 Jun;12(6):e944

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Obesity alters metabolic microenvironment and is thus associated with several tumours. The aim of the present study was to investigate the role, molecular mechanism of action, and potential clinical value of lipid metabolism-related long non-coding RNA (lncRNA) SLC25A21-AS1 in oesophageal squamous cell carcinoma (ESCC).

Methods: A high-fat diets (HFDs)-induced obesity nude mouse model was established, and targeted metabolomics analysis was used to identify critical medium-long chain fatty acids influencing the growth of ESCC cells. Read More

Ann Med Surg (Lond) 2022 Jun 6;78:103907. Epub 2022 Jun 6.

Department of Surgical Gastroenterology and Liver Transplantation, Sir Ganga Ram Hospital, India.

Squamous cell carcinoma (SCC) of the colon is a rare malignancy and usually a pathological surprise. Clinical presentation is usually very similar to adeno carcinoma variety. We report a case of a 56 year old male with primary SCC of caecum presenting as small bowel obstruction and managed with surgery and adjuvant chemotherapy. Read More

Laryngoscope Investig Otolaryngol 2022 Jun 6;7(3):757-765. Epub 2022 May 6.

Department of Hematology/Oncology UPMC Hillman Cancer Center Pittsburgh Pennsylvania USA.

Objectives: Data on the efficacy of including definitive local therapy to the primary site for head and neck squamous cell carcinoma (HNSCC) patients with synchronous distant metastasis are lacking. In multiple different solid tumor types, there has been benefit when using systemic therapy followed by local consolidative therapy (stereotactic ablative radiotherapy or surgery) directed at metastases. We proposed to retrospectively evaluate patients at our institution that received definitive treatment to the primary. Read More

Eur J Nucl Med Mol Imaging 2022 Jun 23. Epub 2022 Jun 23.

Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, Guangdong, China.

Purpose: Accurate assessment of residual disease of tumor and lymph nodes after neoadjuvant immunochemotherapy is crucial in the active surveillance for patients with pathological complete response (pCR) and the optimal extent of lymphadenectomy for patients with non-pCR. This post hoc analysis aimed to evaluate the performance of F-FDG PET/CT to predict the pathological response to neoadjuvant immunochemotherapy for esophageal squamous cell carcinoma (ESCC).

Methods: Fifty-eight resectable ESCC patients received two cycles of camrelizumab in combination with chemotherapy and were enrolled in the final analysis. Read More

Sci Rep 2022 Jun 22;12(1):10513. Epub 2022 Jun 22.

Department of Medical Research, E-Da Hospital/E-Da Cancer Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.

Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide that is characterized by abnormal lesions or malignant hyperplasia of soft and hard tissues in the oral cavity. Previous research has found that HDAC6 may be a potential therapeutic target for cancer patients and has the ability to regulate immune cells. However, the mechanism of HDAC6 in OSCC pathogenesis is unclear. Read More

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):542-547

Department of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China. *Corresponding authors, E-mail:

Objective To investigate whether swelling stress exists in lung cancer cells by comparing water content and nucleus size as well as mitogen activated protein kinase (MAPK) phosphorylation activation between lung cancer tissues and corresponding paracancerous tissues. Methods Differences in water content between fresh specimens of 10 human lung adenocarcinoma, 12 lung squamous cell carcinoma, and corresponding paracancerous normal lung tissues were examined through "dry and wet" mass comparison. The expressions and phosphorylation activation of mitogen activated protein kinases JNK, ERK1/2, and p38 in 30 lung adenocarcinoma samples, 32 lung squamous cell carcinoma samples, and alveolar epithelial cells and lung bronchial epithelial cells of 10 paracancerous normal tissues samples were detected with their phosphorylated and non-phosphorylated antibodies and by immunohistochemical staining. Read More

Cancer Invest 2022 Jun 22:1-39. Epub 2022 Jun 22.

DDS, PhD, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil and Professor, Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil.

We investigated the differences in prognosis according to the type of healthcare coverage of patients with oral and oropharyngeal squamous cell carcinoma (OOSCC). This study included 875 medical records. Patients covered by the publicly funded Unified Health System (SUS) had a low educational level, with advanced T-stage and delayed treatment initiation. Read More

Acta Oncol 2022 Jun 22:1-4. Epub 2022 Jun 22.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.

Int J Oncol 2022 Aug 22;61(2). Epub 2022 Jun 22.

Department of Pathology, Medical College, Jinan University, Guangzhou, Guangdong 510632, P.R. China.

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide with a low 5‑year survival rate due to the lack of effective therapeutic strategies. Accumulating evidence has indicated that maternal embryonic leucine zipper kinase (MELK) is highly expressed in several tumors and associated with tumor development. However, the biological effects of MELK in ESCC remain unknown. Read More