90,624 results match your criteria Pathology - Squamous Cell Carcinoma


Mouse Double Minute 2 Amplification in Esophageal Squamous Cell Carcinoma Associated with Better Outcome.

Histopathology 2020 Jul 11. Epub 2020 Jul 11.

Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.

Aims: This study aimed to determine the frequency of mouse double minute 2 (MDM2) amplification in esophageal squamous cell carcinomas (ESCC) and to clarify its prognostic significance.

Methods: We investigated MDM2 amplification on tissue microarrays, using fluorescence in situ hybridization and analyzed its correlations with clinicopathological features and outcomes in 515 Chinese ESCC patients.

Results: MDM2 amplifications were found in 37 of 515 ESCC patients (7. Read More

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http://dx.doi.org/10.1111/his.14208DOI Listing

HPV-related carcinoma of the oropharynx: challenges on small biopsy specimens.

J Am Soc Cytopathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Human papillomavirus (HPV)-related oropharyngeal carcinoma can morphologically mimic many processes from benign to malignant and lead pathologists to incorrectly diagnose them and/or use inappropriate diagnostic terminology. Recognition of HPV-related oropharyngeal carcinoma and its variants is critical for appropriate prognostic and therapeutic considerations in small biopsy material. Various pitfalls in diagnosing these tumors on limited biopsies are discussed herein. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.06.001DOI Listing

Investigating proteome changes between primary and metastatic cutaneous squamous cell carcinoma using SWATH mass spectrometry.

J Dermatol Sci 2020 Jun 30. Epub 2020 Jun 30.

Centre for Translational Skin Research, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia; Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia. Electronic address:

Background: Cutaneous squamous cell carcinoma (cSCC) is a common malignancy worldwide and the first as the cause of death from keratinocytic carcinomas. Around 5% of primary cSCCs metastasize, leading to a 5-year survival rate of only 11 %.

Objective: This paper aims to investigate the proteome profile of primary and metastatic cSCC lesions for the identification of potential diagnostic biomarkers and molecular alterations. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.06.012DOI Listing

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.

Orphanet J Rare Dis 2020 Jul 10;15(1):183. Epub 2020 Jul 10.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease; Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.

Objective: NUT midline carcinoma (NMC), a rare type of squamous cell carcinoma, is genetically characterised by NUT midline carcinoma family member 1 (NUTM1) gene rearrangement. NMC can arise from the lungs; however, there is no standard for the management of primary pulmonary NMC. This study aimed to confirm the clinical features and report the treatments, especially with immune checkpoint inhibitors (ICIs), and outcomes of patients with primary pulmonary NMC. Read More

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http://dx.doi.org/10.1186/s13023-020-01449-xDOI Listing

Molecular Features of Metaplastic Breast Carcinoma: An Infrequent Subtype of Triple Negative Breast Carcinoma.

Cancers (Basel) 2020 Jul 8;12(7). Epub 2020 Jul 8.

Pathology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.

Metaplastic breast carcinoma (MBC) is a heterogeneous group of infrequent invasive carcinomas that display differentiation of the neoplastic epithelium towards squamous cells and/or mesenchymal-type elements. Most MBC have a triple negative phenotype and poor prognosis. Thus, MBC have worse survival rates than other invasive breast carcinomas, including other triple negative breast carcinomas (TNBC). Read More

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http://dx.doi.org/10.3390/cancers12071832DOI Listing

Whole Genomic Analysis and Comparison of Two Canine Papillomavirus Type 9 Strains in Malignant and Benign Skin Lesions.

Viruses 2020 Jul 8;12(7). Epub 2020 Jul 8.

School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.

Papillomaviruses (PVs) usually cause benign proliferative lesions in the stratified epithelium of various animal species. However, some high-risk types of PVs have been proven to lead to malignant transformations. In dogs, several canine papillomaviruses (CPVs) have been identified in malignant lesions and are suggested as one of the risk factors for the development of squamous cell carcinomas (SCCs). Read More

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http://dx.doi.org/10.3390/v12070736DOI Listing

Whole exome and transcriptome analysis of UV-exposed epidermis and carcinoma in situ reveals early drivers of carcinogenesis.

J Invest Dermatol 2020 Jul 7. Epub 2020 Jul 7.

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA. Electronic address:

Squamous cell carcinoma in situ (SCCIS) is a prevalent precancerous lesion that can progress to cutaneous squamous cell carcinoma (cSCC). Although SCCIS is common, its pathogenesis remains poorly understood. To better understand SCCIS development, we performed laser-captured microdissection of human SCCIS and adjacent epidermis to isolate genomic DNA and RNA for next generation sequencing. Read More

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http://dx.doi.org/10.1016/j.jid.2020.05.116DOI Listing

Machine Learning Predicts Lymph Node Metastasis in Early-Stage Oral Tongue Squamous Cell Carcinoma.

J Oral Maxillofac Surg 2020 Jun 13. Epub 2020 Jun 13.

Professor, Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; and Department Head, Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Purpose: Early-stage oral tongue squamous cell cancer (OTSCC) has a rate of metastasis to the cervical lymph nodes of 20 to 50%. This study aimed to build and validate 4 machine learning (ML) models to predict the occurrence of lymph node metastasis before and after surgery for early-stage (cT1N0 to cT2N0) OTSCC.

Materials And Methods: We designed a retrospective cross-sectional study and reviewed the clinical and pathologic records of patients with early-stage OTSCC. Read More

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http://dx.doi.org/10.1016/j.joms.2020.06.015DOI Listing

Metastatic Mimics of Primary Cutaneous Lesions: Averting Diagnostic Pitfalls With Significant Repercussions.

Am J Dermatopathol 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Hanover, NH.

Cutaneous metastases by solid malignancies often signify advanced disease and portend severely limited survival. Appropriate diagnosis of these lesions is particularly hampered when they closely resemble primary cutaneous tumors. In this article, we present two diagnostically challenging cases of metastatic lesions to the scalp bearing striking histologic resemblance to primary cutaneous neoplasms. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001726DOI Listing

Should uncertainty concerning the risk of malignancy be included in diagnostic (nongynecologic) cytopathology reports?

Cancer Cytopathol 2020 Jul 10. Epub 2020 Jul 10.

Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exact nature of the specimen received, the staining method(s) used, and the use of additional laboratory techniques including molecular profiling; furthermore, they often differ to some extent from institution to institution, between differing cytologists within the same institution, and over time. A brief literature review for a selected group of routine diagnostic cytology specimens shows a published ROM for a confirmed malignant diagnosis as follows: bile duct brushings, ~99% (range, 97%-100%); breast fine needle aspiration, 98. Read More

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http://dx.doi.org/10.1002/cncy.22322DOI Listing

Optimization of therapeutic strategy for p16-positive oropharyngeal squamous cell carcinoma: Multi-institutional observational study based on the national head and neck cancer registry of Japan.

Cancer 2020 Jul 10. Epub 2020 Jul 10.

Department of Otorhinolaryngology, Kindai University Nara Hospital, Nara, Japan.

Background: Although the American Joint Committee on Cancer TNM classification has been amended to include human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) as an independent entity, to the authors' knowledge the optimized de-escalating treatment modality has not been established to date.

Methods: The authors conducted a retrospective, nationwide, observational study in patients with HPV-related OPSCC who were treated from 2011 to 2014 in Japan to determine the best treatment modality.

Results: A total of 688 patients who were newly diagnosed with HPV-related OPSCC who were treated with curative intent at 35 institutions and had coherent clinical information and follow-up data available were included in the current study. Read More

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http://dx.doi.org/10.1002/cncr.33062DOI Listing

Low-dose metformin reprograms the tumor immune microenvironment in human esophageal cancer: Results of a phase II clinical trial.

Clin Cancer Res 2020 Jul 9. Epub 2020 Jul 9.

Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College

Purpose: The tumor immune microenvironment (TIME) has an important impact on response to cancer immunotherapy using immune checkpoint inhibitors. Specifically, an "infiltrated-excluded"/"cold" TIME is predictive of poor response. The antidiabetic agent metformin may influence anti-cancer immunity in esophageal squamous cell carcinoma (ESCC). Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0113DOI Listing

Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.

Immunol Invest 2020 Jul 9:1-15. Epub 2020 Jul 9.

School of Biological Sciences, University of Essex , Colchester, UK.

Lung cancer is a leading cause of cancer-associated death in all over the globe. This study was undertaken to determine the expression and interaction of membrane-bound receptors CD74 and CD44 in human lung adenocarcinoma cells and their associated signaling was also attempted. Levels of CD74 and CD44 were studied in human lung adenocarcinoma-evolved cells A549 and H460. Read More

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http://dx.doi.org/10.1080/08820139.2020.1790594DOI Listing

Gene expression analysis of autofluorescence margins in leukoplakia and oral carcinoma: a pilot study.

Oral Dis 2020 Jul 9. Epub 2020 Jul 9.

Department of Health Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.

Objectives: Autofluorescence is considered a useful technique in the early detection of oral mucosal alterations. However, its efficacy to discriminate tumor margins is still under debate. The purpose of this pilot study was to confirm the existence of molecular divergence from the centre of a lesion compared to white light and autofluorescence (VELscope ) visualized margins in leukoplakia and oral carcinoma. Read More

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http://dx.doi.org/10.1111/odi.13525DOI Listing

Molecular data show conserved DNA locations distinguishing lung cancer subtypes and regulation of immune genes.

Lung Cancer 2020 Jun 20;146:341-349. Epub 2020 Jun 20.

University of Groningen and University Medical Center Groningen, Departments of Pulmonary Diseases and Pathology and Medical Biology, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. Electronic address:

Introduction: Non-small-cell lung cancer exhibits a range of transcriptional and epigenetic patterns that not only define distinct phenotypes, but may also govern immune related genes, which have a major impact on survival.

Methods: We used open-source RNA expression and DNA methylation data of the Cancer Genome Atlas with matched non-cancerous tissue to evaluate whether these pretreatment molecular patterns also influenced genes related to the immune system and overall survival.

Results: The distinction between lung adenocarcinoma and squamous cell carcinoma are determined by 1083 conserved methylation loci and RNA expression of 203 genes which differ for >80 % of patients between the two subtypes. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.008DOI Listing

A Clinicopathologic Review of 21 Cases of Head and Neck Primary Tuberculosis.

J Oral Maxillofac Surg 2020 Jun 14. Epub 2020 Jun 14.

Professor, Oral Diagnosis Department, Collage of Dentistry, Baghdad University, Baghdad, Iraq.

Purpose: A diagnosis of tuberculosis (TB) of the head and neck has been a dilemma for clinicians, because the clinical and pathologic features tend to mimic different pathologies. Our study aimed to identify the demographic, clinical, and pathologic features of head and neck TB to help healthcare providers in the early detection of the disease.

Materials And Methods: We performed a retrospective analysis using the medical archives at the pathology laboratory. Read More

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http://dx.doi.org/10.1016/j.joms.2020.05.048DOI Listing

P53 staining index and zonal staining patterns in actinic keratoses.

Arch Dermatol Res 2020 Jul 8. Epub 2020 Jul 8.

Dermatology Unit, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Actinic keratoses (AKs) are common dysplastic lesions resulting from chronic excessive ultraviolet exposure. Neither the clinical grade of thickness nor the histological grade of dysplasia seems valid predictors of aggressive potential of AKs. Instead, the mutational status in AKs appears to predict well the clinical course. Read More

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http://dx.doi.org/10.1007/s00403-020-02104-yDOI Listing

NADPH oxidase 5α promotes the formation of CD271 tumor-initiating cells in oral cancer.

Am J Cancer Res 2020 1;10(6):1710-1727. Epub 2020 Jun 1.

Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong 21 Sassoon Road, Pokfulam, Hong Kong, China.

Oral tongue squamous cell carcinoma (OTSCC) has a distinctive cell sub-population known as tumor-initiating cells (TICs). CD271 is a functional TIC receptor in head and neck cancers. The molecular mechanisms governing CD271 up-regulation remains unclear. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339284PMC

CMTM6 promotes cell proliferation and invasion in oral squamous cell carcinoma by interacting with NRP1.

Am J Cancer Res 2020 1;10(6):1691-1709. Epub 2020 Jun 1.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University Nanjing, China.

Previous studies have identified that both CKLF-like MARVEL transmembrane domain-containing member (CMTM6) and Neuropilin-1 (NRP1) played an essential part in regulating tumorigenesis and immune response. However, the potential connection between CMTM6 and NRP1 in oral squamous cell carcinoma (OSCC) remains unknown. In this study, we investigated the clinicopathologic significance of CMTM6 and NRP1 in OSCC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339282PMC

Tumor infiltrating T cells influence prognosis in stage I-III non-small cell lung cancer.

J Thorac Dis 2020 May;12(5):1824-1842

Gerhard Domagk Institute of Pathology, University Hospital Muenster, Muenster, Germany.

Background: T cell infiltration in non-small cell lung cancer (NSCLC) is essential for the immunological response to malignant tissue, especially in the era of immune-checkpoint inhibition. To investigate the prognostic impact of CD4 T helper cells (T), CD8 cytotoxic (T) and FOXP3 regulatory T (T) cells in NSCLC, we performed this analysis.

Methods: By counterstaining of CD4, CD8 and FOXP3 we used immunohistochemistry on tissue microarrays (TMA) to evaluate peritumoral T cells, T cells and T cells in n=294 NSCLC patients with pTNM stage I-III disease. Read More

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http://dx.doi.org/10.21037/jtd-19-3414aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330340PMC

Mediastinal Neuroendocrine Carcinoma Slowly Growing for 8 Years after Surgical Resection of Esophageal Squamous Cell Carcinoma.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan.

A 70-year-old woman was referred to our department due to a solitary mediastinal tumor which gradually grew near the site of anastomosis for 8 years after radical surgery of esophageal squamous cell carcinoma. It was difficult to distinguish the lymph node recurrence of esophageal cancer from another tumor of unknown primary origin. Endoscopic ultrasound-guided fine-needle aspiration was performed, and the tumor was diagnosed to be neuroendocrine carcinoma. Read More

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http://dx.doi.org/10.2169/internalmedicine.4584-20DOI Listing

Prognostic Significance of RAS Mutations and P53 Expression in Cutaneous Squamous Cell Carcinomas.

Genes (Basel) 2020 Jul 6;11(7). Epub 2020 Jul 6.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.

is considered the most commonly-altered gene in cutaneous squamous cell carcinoma (cSCC). Conversely, mutations have been reported in a low percentage of cSCC. The objective of our study was to evaluate the frequency of p53 expression and mutations in cSCC and correlate them with clinicopathological features and patient outcome. Read More

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http://dx.doi.org/10.3390/genes11070751DOI Listing

Dietary Fat and Male Sex Increase Histopathological Changes in a Mouse Model of Oral Cancer.

Oral Dis 2020 Jul 8. Epub 2020 Jul 8.

College of Dental Medicine-Illinois, Midwestern University, Downers Grove, IL, United States.

Objective: To compare the effects of dietary fat and sex on murine oral squamous cell carcinoma pathology.

Materials And Methods: Male and female C57Bl/6 mice (36/sex) received a low-fat (10 kcal%) or high-fat (60 kcal%) diet. Water (control), vehicle, or 4-nitroquinoline-1-oxide in vehicle (50 µg/ml) was provided for 17 weeks followed by 6 additional weeks of water. Read More

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http://dx.doi.org/10.1111/odi.13542DOI Listing

Anal dysplasia as an incidental finding: the importance of specimen evaluation.

Colorectal Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL, USA.

Purpose: The incidence of anal squamous cell carcinoma (SCC) has increased dramatically in the USA. The squamous intraepithelial lesion (SIL) has been identified as a precursor lesion to SCC, stratifying the abnormality into low grade (LSIL) or high grade (HSIL). There have been studies on the prevalence of incidentally found SCC in haemorrhoidectomy specimens, there are no studies to date on the incidence of dysplasia. Read More

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http://dx.doi.org/10.1111/codi.15244DOI Listing

Vulvar intraepithelial neoplasia: incidence and long-term risk of vulvar squamous cell carcinoma.

Int J Cancer 2020 Jul 7. Epub 2020 Jul 7.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam, Amsterdam, Netherlands.

The risk of vulvar squamous cell carcinoma (VSCC) in patients with high-grade vulvar intraepithelial neoplasia (VIN) is considered lower in high-grade squamous intraepithelial lesion (HSIL) compared to differentiated VIN (dVIN), but studies are limited. This study investigated both the incidence of high-grade VIN and the cumulative incidence of VSCC in patients with HSIL and dVIN separately. A database of women diagnosed with high-grade VIN between 1991 and 2011 was constructed with data from the Dutch Pathology Registry (PALGA). Read More

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http://dx.doi.org/10.1002/ijc.33198DOI Listing

Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report.

SAGE Open Med Case Rep 2020 24;8:2050313X20935260. Epub 2020 Jun 24.

Division of Radiation Oncology, Department of Oncology, University of Alberta, Edmonton, AB, Canada.

Basaloid squamous cell carcinoma is an infiltrative and aggressive variant of squamous cell carcinoma with basaloid features. Primary skin-derived basaloid squamous cell carcinoma is rare. Basaloid squamous cell carcinoma is commonly observed in the oropharyngeal and anogenital regions and is associated with high-risk human papillomavirus. Read More

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http://dx.doi.org/10.1177/2050313X20935260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318809PMC

Greater specificity of p40 compared with p63 in distinguishing squamous cell carcinoma from adenocarcinoma in effusion cellblocks.

Cytojournal 2020 8;17:13. Epub 2020 Jun 8.

Department of Pathology, Chonnam National University Medical School, Gwangju, Republic of Korea.

Objective: Squamous cell carcinoma (SCC) rarely causes malignant effusions. Distinguishing between SCC and adenocarcinoma in effusion cytology can be a challenge. p63 and p40 have been frequently used to support squamous cell differentiation in both histological and cytological specimens. Read More

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http://dx.doi.org/10.25259/Cytojournal_78_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332517PMC

antiproliferation activity of leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines.

Vet World 2020 May 19;13(5):931-939. Epub 2020 May 19.

Division of Pharmacy, Faculty of Veterinary Medicine; IPB University, Bogor, Indonesia.

Background And Aim: Tumor disorder is one of the degenerative diseases that affected human and animals and recently is tend to increase significantly. The treatment of tumor diseases can be performed through surgical, chemotherapy, radiotherapy, biological substances, and herbs medicine. leaves extract known to have an antiproliferation activity, while interferons (IFNs) one of the cytokines that first used as an antiviral agent was also known to have antitumor activity. Read More

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http://dx.doi.org/10.14202/vetworld.2020.931-939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311872PMC

Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis.

J Dermatol Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. Electronic address:

Background: Mitochondrial morphology is controlled by fission and fusion. Dynamin-related protein 1 (Drp1, dynamin-1-like protein (Dnml1)) regulates mitochondrial fission, which is associated with cell division and apoptosis. We previously reported that DRP1 is indispensable for cell growth in cutaneous squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.06.009DOI Listing

Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification.

Cancers (Basel) 2020 Jul 4;12(7). Epub 2020 Jul 4.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

The tumor immune microenvironment (TIME) plays an important role in penile squamous cell carcinoma (peSCC) pathogenesis. Here, the immunophenotype of the TIME in peSCC was determined by integrating the expression patterns of immune checkpoints (programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and Siglec-15) and the components of tumor-infiltrating lymphocytes, including CD8 or Granzyme B T cells, FOXP3 regulatory T cells, and CD68 or CD206 macrophages, in 178 patients. A high density of Granzyme B, FOXP3, CD68, CD206, PD-1, and CTLA-4 was associated with better disease-specific survival (DSS). Read More

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http://dx.doi.org/10.3390/cancers12071796DOI Listing

Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma.

Cancers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Section of Neuroradiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, 789 Howard Ave, New Haven, CT 06519, USA.

Accurate risk-stratification can facilitate precision therapy in oropharyngeal squamous cell carcinoma (OPSCC). We explored the potential added value of baseline positron emission tomography (PET)/computed tomography (CT) radiomic features for prognostication and risk stratification of OPSCC beyond the American Joint Committee on Cancer (AJCC) 8th edition staging scheme. Using institutional and publicly available datasets, we included OPSCC patients with known human papillomavirus (HPV) status, without baseline distant metastasis and treated with curative intent. Read More

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http://dx.doi.org/10.3390/cancers12071778DOI Listing

The addition of tumour-stroma ratio to the 8th AJCC staging system improves survival prediction in oral tongue squamous cell carcinoma.

Histopathology 2020 Jul 7. Epub 2020 Jul 7.

Department of Clinical and Experimental Medicine, Foggia University, Foggia, Italy.

Background: One of the objectives of current researches is to customise the treatment of cancer patients. This objective requires stratification of patients based on the most significant prognostic factors. The aim of this study was to evaluate the prognostic value of tumour-stroma ratio (TSR), defined as the proportion of tumour cells relative to surrounding stroma, in patients with Oral Tongue Squamous Cell Carcinoma (OTSCC) and to develop a prognostic nomogram based on the most significant clinico-pathological features. Read More

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http://dx.doi.org/10.1111/his.14202DOI Listing

ASO Author Reflections: Perineural Invasion in pN0M0 Esophageal Squamous Cell Carcinoma: Let Pathology Strengthen the Clinical Oncology Practice.

Ann Surg Oncol 2020 Jul 6. Epub 2020 Jul 6.

Department of Pathology and Institute of Clinical Pathology, Shantou University Medical College, Shantou, China.

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http://dx.doi.org/10.1245/s10434-020-08698-xDOI Listing

Phantom simulation of liver metastasis on a positron emission tomography with computed tomography scan after neoadjuvant chemoradiotherapy for distal esophageal cancer: a case report.

J Med Case Rep 2020 Jul 7;14(1):106. Epub 2020 Jul 7.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.

Background: Neoadjuvant chemoradiotherapy is currently the gold standard treatment for esophageal cancer prior to surgery. This radiation therapy will sometimes lead to liver damage parallel to esophageal lesions, which mimics liver metastasis visualized by F-fluorodeoxyglucose positron emission tomography with computed tomography. In this report, we publish virtual radiation-induced liver damage images obtained during surgery, along with the coherent pathology, in order to confirm the false-positive result through an optimally decisive radiological examination. Read More

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http://dx.doi.org/10.1186/s13256-020-02391-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339402PMC

Macrophages in Oral Carcinomas: Relationship with Cancer Stem Cell Markers and PD-L1 Expression.

Cancers (Basel) 2020 Jul 2;12(7). Epub 2020 Jul 2.

Head and Neck Oncology UnitInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33011 Oviedo, Asturias, Spain.

Tumor-associated macrophages (TAMs) can be polarized into antitumoral M1 and protumoral and immunosuppressive M2 macrophages. This study investigated the clinical relevance of TAM infiltration in oral squamous cell carcinoma (OSCC), evaluating CD68 (M1 and M2 macrophage marker) and CD163 expression (M2 macrophage marker) in the tumor nests and surrounding stroma. Immunohistochemical analysis of both stromal/tumoral CD68 and CD163 TAMs was performed in paraffin-embedded tissue specimens from 125 OSCC patients, and correlated with clinical data. Read More

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http://dx.doi.org/10.3390/cancers12071764DOI Listing

Metastatic squamous cell carcinoma transformed from prostatic adenocarcinoma following androgen deprivation therapy: A case report with clinicopathologic and molecular findings.

Diagn Cytopathol 2020 Jul 6. Epub 2020 Jul 6.

VA Palo Alto Health Care System, Pathology and Laboratory Service, Palo Alto, California, USA.

Squamous cell carcinoma (SCC) of the prostate is a rare and clinically aggressive entity that may arise de novo or through transformation of prostatic adenocarcinoma, typically following hormonal or radiation therapy. Confirmation of prostatic origin, especially when evaluating a metastatic focus, often requires correlation with clinical and imaging findings, as the morphologic and immunohistochemical features of SCC are not organ-specific. Comprehensive genomic profiling (CGP) may provide additional information useful for confirming the primary site and for identifying potential targeted therapy options. Read More

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http://dx.doi.org/10.1002/dc.24539DOI Listing

and variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients.

Tumour Biol 2020 Jul;42(7):1010428320938494

Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of c.215G > C, c. Read More

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http://dx.doi.org/10.1177/1010428320938494DOI Listing

Clinical, histopathological and immunohistochemical evaluation of daylight photodynamic therapy in the treatment of field cancerization: a study of 30 cases.

J Dermatolog Treat 2020 Jul 7:1-7. Epub 2020 Jul 7.

Dermatology Department of ABC Medical School, Santo Andre, Brazil.

Background: Actinic keratosis (AK) are pre-malignant lesions, precursors of squamous cell carcinoma (SCC). Normal skin adjacent to AK, may present initial mutations with potential risk for new neoplasms, currently known today as field cancerization (FC).

Objectives: To evaluate the effectiveness of daylight photodynamic therapy (PDT) with methyl amino levulinate (MAL) based on clinical evaluation, histological examination and immunohistochemical expression of p53 and Ki67. Read More

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http://dx.doi.org/10.1080/09546634.2020.1789042DOI Listing

Tumor-free margins and local recurrence in squamous cell carcinoma of the vulva.

Gynecol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical and Surgical Gynecology, Mayo Clinic, Phoenix, AZ, USA. Electronic address:

Objective: To investigate the relation of pathologic tumor-free margins and local recurrence in patients who underwent primary surgery for vulvar squamous cell carcinoma.

Methods: In this retrospective analysis, patients with stage I-III vulvar squamous cell carcinoma who underwent primary surgery between 2000 and 2018 were identified from the Mayo Clinic Cancer Registry.

Results: A total of 335 patients were included and divided into three groups according to tumor-free margins: group 1 (<3 mm, n = 32); group 2 (≥3 to <8 mm, n = 151); group 3 (≥8 mm, n = 152). Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.06.503DOI Listing

The clinical significance of Interleukin 24 and its potential molecular mechanism in laryngeal squamous cell carcinoma.

Cancer Biomark 2020 Jun 28. Epub 2020 Jun 28.

Department of Research, Guangxi Medical University Cancer Hospital, Guangxi, China.

Interleukin 24 (IL24) has been documented to be highly expressed in several cancers, but its role in laryngeal squamous cell carcinoma (LSCC) remains unclarified. In this study, to reveal the function and its clinical significance of IL24 in LSCC, multiple detecting methods were used comprehensively. IL24 protein expression was remarkably higher in LSCC (n= 49) than non-cancerous laryngeal controls (n= 26) as detected by in-house immunohistochemistry. Read More

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http://dx.doi.org/10.3233/CBM-201441DOI Listing

Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence.

Radiother Oncol 2020 Jul 2. Epub 2020 Jul 2.

Experimental Clinical Oncology, Aarhus University Hospital, Denmark; Department of Oncology, Aarhus University Hospital, Denmark.

Background: Measuring circulating-free-deoxyribonucleic-acid (cfDNA) has created a new framework for personalized treatment in oncology. The aim of this study was to analyze the relation between cfDNA and risk factors and outcome in squamous cell carcinoma of the anus (SCCA).

Methods: Patients treated with radiotherapy for localized SCCA were included in Aarhus, Denmark from 2016 -2019. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.06.045DOI Listing

Procedures and pitfalls in incisional biopsies of oral squamous cell carcinoma with respect to histopathological diagnosis.

Dis Mon 2020 Jul 1:101035. Epub 2020 Jul 1.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

This review has addressed the issues faced by a diagnostic pathologist during routine assessment of haematoxylin and eosin stained incisional biopsies from oral squamous cell carcinoma patients. Herein, the pragmatic means undertaken, has highlighted routinely faced problems & encounters determined at various levels as clinical, laboratory and diagnostic pitfalls, when possible, tips offered towards procedures and guidance. Also, dealt with subtypes of oral squamous cell carcinoma, differential diagnosis, and relevant prognostic indicators that can navigate the surgeon to take quick decisions. Read More

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http://dx.doi.org/10.1016/j.disamonth.2020.101035DOI Listing

Functional Significance and Therapeutic Potential of miRNA-20b-5p in Esophageal Squamous Cell Carcinoma.

Mol Ther Nucleic Acids 2020 Jun 12;21:315-331. Epub 2020 Jun 12.

School of Clinical Medicine, Affiliated Hospital, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, China; Department of Radiation Oncology, North China University of Science and Technology Affiliated People's Hospital, Tangshan 063000, China. Electronic address:

Novel therapies tailored to the molecular composition mechanism of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. miR-20b-5p expression was significantly upregulated in cancerous tissues and associated with lymph node metastasis, clinical stage, and overall survival (OS). An analysis of the methylation status of the miR-20b-5p gene indicated that the hypomethylation of the CpG sites located upstream of the miR-20b-5p gene in the ESCC tissues was more frequent than in the adjacent normal tissues, and the methylation status of miR-20b-5p correlated inversely with its expression levels. Read More

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http://dx.doi.org/10.1016/j.omtn.2020.05.015DOI Listing

The incidence of squamous cell carcinoma of the oral tongue is rising in young non-smoking women: An international multi-institutional analysis.

Oral Oncol 2020 Jul 1;110:104875. Epub 2020 Jul 1.

Central Clinical School, University of Sydney, Parramatta Road, Camperdown, NSW 2050, Australia; Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW 2050, Australia. Electronic address:

Purpose: Increasing evidence is accumulating for an alarming rising incidence of oral tongue SCC in a younger cohort, particularly in developed countries. The aim of this study is to analyse the change in incidence of OSCC in patients under the age of 45 in developed nations in the Asia-Pacific region.

Patients And Methods: Population data was extracted from the Australian Cancer Incidence and Mortality 2017 database and National Registry of Diseases Office, Singapore to allow calculation of the incidence in the Australian and Singaporean populations. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104875DOI Listing

Signet-ring squamous cell carcinoma: a report of a rare variant and review of the literature.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Pathology, Warren Alpert Medical School of Brown/Rhode Island Hospital, Providence, RI.

Signet-ring squamous cell carcinoma is a rare histological subtype of squamous cell carcinoma. The distinct morphologic appearance of this variant can mimic metastatic adenocarcinoma and impose a diagnostic challenge. Unlike its glandular counterpart, signet-ring cell variant of squamous cell carcinoma has a poorly characterized histopathogenesis with no known prognostic implication. Read More

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Submucosal gland neoplasms of the esophagus: an update and review.

Esophagus 2020 Jul 3. Epub 2020 Jul 3.

Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Jiangsu Province, 210008, Nanjing, People's Republic of China.

Submucosal glands (SMGs) present throughout human esophagus with clusters at either the upper third or lower third of the organ. SMGs tend to atrophy with age, and neoplasms arising in these glands are rare. In order to bring convenience to diagnosis, we summarize the histopathologic characteristics of all esophageal submucosal gland tumors (SGTs). Read More

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http://dx.doi.org/10.1007/s10388-020-00758-1DOI Listing

Synchronous Primary Pancreatic Ductal Carcinoma and Colonic Adenocarcinoma Present in a Patient With History of Skin Squamous Cell Carcinoma.

Anticancer Res 2020 Jul;40(7):4029-4032

Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.

The synchronous diagnosis of two or more primary malignancies in a patient is overall rare. This is a case report of a 70-year-old female with a history of skin squamous cell carcinoma presenting with occult hematochezia. Colonoscopy and biopsy results confirmed a microsatellite stable (MMS) adenocarcinoma in the ascending colon, and subsequent computed tomography (CT) scans identified a 3. Read More

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http://dx.doi.org/10.21873/anticanres.14398DOI Listing

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas.

Anticancer Res 2020 Jul;40(7):4017-4022

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Naples, Italy

Background/aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT). It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Read More

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http://dx.doi.org/10.21873/anticanres.14396DOI Listing

Comprehensive Analysis and Clinical Implication of PD-L1 Expression Considering HPV Status in Oropharyngeal Squamous Cell Carcinoma.

Anticancer Res 2020 Jul;40(7):4001-4010

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background/aim: This study was conducted to comprehensively evaluate programmed cell death ligand 1 (PD-L1) expression, and analyze the clinical and prognostic implications of PD-L1 expression in oropharyngeal squamous cell carcinoma (OPSCC).

Patients And Methods: We evaluated the expression of PD-L1 using the antibodies SP263 and SP142 in 106 patients with OPSCC, using immunohistochemistry. PD-L1 expression was subdivided into tumor cell score (TC), immune cell score (IC), and combined score (CS). Read More

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http://dx.doi.org/10.21873/anticanres.14394DOI Listing

Photosensitizer With Illumination Enhances Antitumor Effect of Anti-ROBO1 Immunotoxin on Maxillary Sinus Squamous Cell Carcinoma.

Anticancer Res 2020 Jul;40(7):3793-3799

Department of Protein-protein Interaction Research, Institute for Advanced Medical Sciences, Nippon Medical School, Kawasaki, Japan

Background/aim: Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of cancer worldwide. Our study focused on the axon guidance receptor roundabout guidance receptor 1 (ROBO1) as a target for monoclonal antibody therapy of HNSCC. We previously showed that saporin-conjugated anti-ROBO1 (B5209B) immunotoxin (IT-ROBO1) enhanced cytotoxic effects on HNSCC cells in combination with the photosensitizer aluminum phthalocyanine disulphonate (AlPcS2a) and illumination. Read More

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http://dx.doi.org/10.21873/anticanres.14368DOI Listing