15,613 results match your criteria Pathology - Basal Cell Carcinoma

Case report of bilateral ovarian fibromas associated with de novo germline variants in PTCH1 and SMARCA4.

Mol Genet Genomic Med 2022 Jun 30:e2005. Epub 2022 Jun 30.

Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Background: Ovarian sex cord-stromal tumors (OSCTs) are rare ovarian tumors that can develop from sex cord, stromal cells, or both. OSCTs can be benign or malignant. Bilateral and/or unilateral ovarian fibromas, a type of OSCT of the stromal cells, have been reported in individuals diagnosed with nevoid basal cell carcinoma syndrome (NBCCS). Read More

View Article and Full-Text PDF

Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response.

Front Med (Lausanne) 2022 14;9:893063. Epub 2022 Jun 14.

Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Basal cell carcinoma (BCC) is the most common form of skin cancer, affecting more often elderly patients, but sometimes even younger ones, particularly if immunocompromised or genetically predisposed. Specifically, the Gorlin-Goltz syndrome, an autosomal dominant genodermatosis, also known as nevoid basal cell carcinoma syndrome, characterizes for multiple early onset BCCs. It is caused by a germline mutation in , a tumor suppressor gene whose product is the key component of Hedgehog (Hh) signaling pathway, which also appears somatically mutated in more than 85% of sporadic BCCs. Read More

View Article and Full-Text PDF

An approach to evaluating scrotal skin-based lesions: A case report of Basal Cell Carcinoma of the Scrotum in patient with multiple risk factors.

Urol Case Rep 2022 Sep 17;44:102130. Epub 2022 Jun 17.

Department of Urology, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia.

Basal cell carcinoma (BCC) is rare on non-sun exposed skin such as the scrotum and thus diagnosis is often delayed. This case highlights an approach to scrotal skin lesions, risk factors and diagnostic features of BCC. Importantly, scrotal BCCs are more likely to metastasise than non-scrotal BCCs. Read More

View Article and Full-Text PDF
September 2022

Periocular basal cell carcinoma results and surgical outcome during a 5-year period in a larger Danish population.

BMC Ophthalmol 2022 Jun 28;22(1):282. Epub 2022 Jun 28.

Department of Ophthalmology, Sygehus Lillebaelt, 7100, Vejle, Denmark.

Background: To report tumour pathology, surgical procedure, complication rates and overall outcome of periocular basal cell carcinoma (BCC) in the Department of Ophthalmology at Sygehus Lillebaelt, Southern Denmark Region over a 5-year period.

Methods: Medical records for all patients who underwent surgery for periocular BCC between January 2016 and December 2020 were reviewed. All tumours were excised with a 3 mm margin beyond the clinically apparent delimitation of the tumour and analysed by frozen section histological examination. Read More

View Article and Full-Text PDF

Metastatic insidious super giant basal cell carcinoma.

BMJ Case Rep 2022 Jun 27;15(6). Epub 2022 Jun 27.

Yale-Waterbury Internal Medicine Residency, Yale University School of Medicine, Waterbury, Connecticut, USA

A middle-aged woman presented with a mechanical fall. Physical examination revealed a massive purulent ulcerated lesion spanning her entire back and axilla, which had reportedly been brewing for over a decade. Punch biopsy revealed infiltrative basal cell carcinoma. Read More

View Article and Full-Text PDF

WHO Classification of Tumours 5th Edition: Evolving Issues in Classification, Diagnosis and Prognostication of Prostate Cancer.

Histopathology 2022 Jun 27. Epub 2022 Jun 27.

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.

The 5 edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems encompasses several updates to the classification and diagnosis of prostatic carcinoma as well as incorporating advancements in assessment of its prognosis, including recent grading modifications. Some of the salient aspects include: 1) recognition that PIN-like carcinoma is not synonymous with a pattern of ductal carcinoma but better classified as a subtype of acinar adenocarcinoma; 2) a specific section on treatment-related neuroendocrine prostatic carcinoma in view of the tight correlation between androgen deprivation therapy and the development of prostatic carcinoma with neuroendocrine morphology, and the emerging data on lineage plasticity; 3) a terminology change of basal cell carcinoma to "adenoid cystic (basal cell) cell carcinoma" given the presence of an underlying MYB::NFIB gene fusion in many cases; 4) discussion of the current issues in the grading of acinar adenocarcinoma and the prognostic significance of cribriform growth patterns; and 5) more detailed coverage of intraductal carcinoma of prostate (IDC-P) reflecting our increased knowledge of this entity, while recommending the descriptive term atypical intraductal proliferation (AIP) for lesions falling short of IDC-P but containing more atypia than typically seen in high-grade prostatic intraepithelial neoplasia (HGPIN). Lesions previously regarded as cribriform patterns of HGPIN are now included in the AIP category. Read More

View Article and Full-Text PDF

Basal cell carcinoma of the prostate: a case report responding to the FGFR inhibitor pemigatinib and literature review.

Curr Opin Urol 2022 Jul;32(4):358-363

Department of Pathology, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: Due to the limited number of cases, there are no guidelines for basal cell carcinoma (BCC) of the prostate. This review combines an unpublished case report of a 55-year-old patient with BCC with an assessment of the latest literature.

Recent Findings: BCC of the prostate has previously been described in only approximately 140 cases. Read More

View Article and Full-Text PDF

Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.

PLoS One 2022 24;17(6):e0268693. Epub 2022 Jun 24.

Department of Medicine, University of Chicago, Chicago, IL, United States of America.

Maternal embryonic leucine-zipper kinase (MELK) regulates cell cycle progression and is highly expressed in many cancers. The molecular mechanism of MELK dysregulation has not been determined in aggressive forms of breast cancer, such as triple negative breast cancer (TNBC). To evaluate molecular markers of MELK aberrations in aggressive breast cancer, we assessed MELK gene amplification and expression in breast tumors. Read More

View Article and Full-Text PDF

[Translated article] Histologically agressive basal cell carcinoma with particular emphasis on galeal infiltration of the scalp.

Actas Dermosifiliogr 2022 Jun 11;113(6):T575-T582. Epub 2022 May 11.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.

Familiarity with predictors of more aggressive behavior is crucial to the management of basal cell carcinoma (BCC). Risk factors for aggressive BCC are essentially divided into clinical and histopathologic factors. In this review we examine histopathologic features predictive of aggressiveness in BCC. Read More

View Article and Full-Text PDF

Secondary Malignant Tumors Arising in Nevus Sebaceus: Two Case Reports.

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Dermatology, International University of Health and Welfare, Narita 286-8520, Chiba, Japan.

Nevus sebaceus is a benign tumor that is present at birth and is often seen on the scalp or face. Secondary malignant tumors sometimes occur in nevus sebaceus in adulthood. Herein, we present two malignant tumors arose from nevus sebaceus. Read More

View Article and Full-Text PDF

Evaluation of Heterogeneous Nuclear Ribonucleoprotein D Expression as a Diagnostic Marker for Oral Squamous Cell Carcinoma.

Diagnostics (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.

The heterogeneous nuclear ribonucleoprotein D (hnRNPD) serves as a prognostic marker for oral squamous cell carcinoma (OSCC). We evaluated the diagnostic potential of hnRNPD to differentiate between OSCC and normal mucosa. Immunohistochemistry for hnRNPD and a routinely used diagnostic marker deltaNp63 (p40) was performed in 32 normal mucosae and 46 OSCC specimens. Read More

View Article and Full-Text PDF

Expression of Matrix Metalloproteinases 7 and 9, Desmin, Alpha-Smooth Muscle Actin and Caldesmon, in Odontogenic Keratocyst Associated with NBCCS, Recurrent and Sporadic Keratocysts.

Biomolecules 2022 Jun 2;12(6). Epub 2022 Jun 2.

Department of Medical and Surgical Sciences, University of Catania, 95123 Catania, Italy.

Nevoid basal cell carcinoma syndrome (NBCCS) associated odontogenic keratocysts (OKCs) show more aggressive behavior and it has a higher frequency of relapse than non-syndromic OKCs. Stromal myofibroblasts (MFs), characterized by α-smooth muscle actin (αSMA), desmin and caldesmon expression, and metalloproteinases (MMPs) have an essential role in the remodeling of the extracellular matrix (ECM). The aim of the study is to analyze the immunohistochemical expression of MMP-7, MMP-9, αSMA and other new markers in the study of OKCs MFs such as desmin and caldesmon in NBCCS-associated OKCs compared to recurrent and sporadic keratocysts. Read More

View Article and Full-Text PDF

[Overtreatment of patients with basal cell carcinoma: active surveillance should be considered more often].

Ned Tijdschr Geneeskd 2022 05 31;166. Epub 2022 May 31.

Maastricht UMC+, afd. Dermatologie, Maastricht.

Basal cell carcinoma (BCC) is the most common cancer type in the Netherlands and frequently diagnosed in older adults. Unlike other common forms of skin cancer (squamous cell carcinoma and melanoma), BCC generally grows slowly and the risk of metastasis and/or death is extremely small. In the first years after presentation, BCC often causes no or only minor complaints. Read More

View Article and Full-Text PDF

An Up-to-Date Correlation of Epidemiological and Histopathological Characteristics of Basal Cell Carcinoma of the Skin in a County Hospital in Romania.

Dermatopathology (Basel) 2022 Jun 18;9(2):183-195. Epub 2022 Jun 18.

Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania.

: Basal carcinoma of the skin (BCC) is part of the nonmelanoma skin cancer (NMSC) family and is the most frequently occurring type of skin cancer in humans. A combination of clinical and histopathological approaches is necessary in order to establish the best treatment regime for patients who have been diagnosed with this type of cancer. The objective of the present study was to establish the statistical value of prediction for certain sociodemographic characteristics (age category and environment of origin) and histopathological parameters of the subjects that could be related to the incidence of diagnosis with certain histopathological subtypes of BCC. Read More

View Article and Full-Text PDF

Recurrent cutaneous basal cell carcinoma after surgical excision: A retrospective clinicopathological study.

Ann Med Surg (Lond) 2022 Jun 26;78:103877. Epub 2022 May 26.

Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt.

Background: Recurrence of basal cell carcinoma (BCC) after complete surgical excision is rarely reported. Risk factors for this negative outcome are not well-studied. We present the clinical and histological features of recurrent BCCs in our institution. Read More

View Article and Full-Text PDF

Use of the O-Z Flap to Repair Scalp Defects After Cancer Tumor Resection.

J Craniofac Surg 2022 May 26;33(3):892-894. Epub 2021 Oct 26.

Ningbo City First Hospital, Ningbo, China.

Background: Large benign and malignant tumors in the scalp cannot be sutured directly after resection. Instead, skin grafting or skin flap repair is the most commonly used techniques. Local tissue depression and lack of hair growth are some of the drawbacks associated with these techniques. Read More

View Article and Full-Text PDF

The correlation between tumor thickness and aggressive histopathological pattern in Basal cell carcinoma.

J Cosmet Dermatol 2022 Jun 28;21(6):2577-2580. Epub 2021 Sep 28.

Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkey.

Background: The significance of tumor thickness is not clear in the prognosis of basal cell carcinoma. We aimed to identify the relationship between the tumor thickness and aggressive histopathological growth pattern in BCC.

Methods: We retrospectively reviewed 85 primary BCCs of 82 patients. Read More

View Article and Full-Text PDF

[Reconstruction of facial skin defects by the V-Y subcutaneous pedicle flap].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):718-723

Department of Otolaryngology, Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, China.

To investigate the method and efficacy of reconstruction of facial skin defects after removing the lesions by applying the V-Y subcutaneous pedicle flap. A retrospective analysis was performed on 23 patients with facial reconstruction by using V-Y subcutaneous pedicle flap in the Otolaryngology Department of Guangdong Integrated Traditional Chinese and Western Medicine Hospital from March 2012 to April 2021. Patient ages ranged from 45 to 85 years old, with a mean age of 66. Read More

View Article and Full-Text PDF

Perianal basal cell carcinoma managed with wide excision and random flap reconstruction.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Surgery, University of the Philippines-Philippine General Hospital, Manila, Metro Manila, Philippines.

Basal cell carcinoma (BCC) is a common skin malignancy and usually occurs in sun-exposed areas like the head and neck. Occurrence in the perianal area is rare, accounting for only 0.08% of all BCC, and 0. Read More

View Article and Full-Text PDF

Surgery combined with photodynamic therapy versus surgery alone for the treatment of non-melanoma skin cancer and actinic keratosis: A retrospective cohort study.

Dermatol Ther 2022 Jun 18:e15652. Epub 2022 Jun 18.

Department of Pathology, Panzhihua Central Hospital, Panzhihua, Sichuan, China.

Photodynamic therapy (PDT) is an effective treatment for some non-melanoma skin cancers (NMSC) and actinic keratosis. To compare recurrence-free survival (RFS) rates between surgery alone and surgery with postoperative PDT in patients with NMSC in China. This retrospective cohort study included patients with pathologically confirmed NMSC or actinic keratosis treated by surgical excision with/without PDT. Read More

View Article and Full-Text PDF

Basal cell carcinoma of the scalp shows distinct features from the face in Asians.

Sci Rep 2022 Jun 17;12(1):10183. Epub 2022 Jun 17.

Department of Dermatology, Seoul National University Bundang Hospital, 82 Gumi-Ro 173 Beon-Gil, Seongnam, 13620, Gyeonggi, Korea.

Basal cell carcinoma (BCC) affecting different sites has been reported to have different clinicopathological features. In previous studies, the scalp was commonly classified to the head and neck region. However, the scalp has distinct characteristics from those of other parts of the skin. Read More

View Article and Full-Text PDF

Perianal Basal Cell Carcinoma: 35-Year Experience.

Dis Colon Rectum 2021 Dec 27. Epub 2021 Dec 27.

Division of Colon and Rectal Surgery, Mayo Clinic Rochester, Minneapolis.

Background: Basal cell carcinoma of the perianal region is a rare anorectal disease. This condition is not related to exposure to ultra-violet radiation. Due to the low prevalence and poor detection, there is a paucity of data relating to this condition in literature. Read More

View Article and Full-Text PDF
December 2021

Periocular Pigmented Basal Cell Carcinomas: Clinicopathologic Features and Mutational Profile.

Ophthalmic Plast Reconstr Surg 2022 Jun 14. Epub 2022 Jun 14.

King Khaled Eye Specialty Hospital, Riyadh, Saudi Arabia.

Purpose: Pigmented basal cell carcinomas (PBCC) is an uncommon variant of basal cell carcinoma of the periocular region with limited information in the literature. We highlight the clinicopathological profile and somatic mutations in periocular PBCC.

Methods: The clinicopathological features and somatic mutations in patients with periocular PBCC were examined and compared with periocular non-PBCC reported in the literature. Read More

View Article and Full-Text PDF

Mohs Micrographic Surgery in Squamous Cell Carcinoma of the Nail Unit.

Actas Dermosifiliogr 2022 05 17;113(5):526-528. Epub 2021 Nov 17.

Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.

View Article and Full-Text PDF

Vismodegib and Sonidegib in Locally Advanced and Metastatic Basal Cell Carcinoma: Update on Hedgehog Pathway Inhibitors.

Actas Dermosifiliogr 2022 May 31;113(5):443-450. Epub 2022 Jan 31.

Servicio de Dermatología y Venerología, Facultad de Medicina, Universidad Hasanuddin, Makassar, Indonesia.

As one of the most common malignancies, basal cell carcinoma (BCC) has evolved as a global burden with incidence annually rising, especially in the older population. Even though the condition is mostly localized, the nature of the disease is destructive and can evolve as either locally advanced BCC (laBCC) or even more rarely as metastatic BCC (mBCC). There are well-established conventional treatment options for these cases, including surgeries and radiotherapy. Read More

View Article and Full-Text PDF

Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment.

Sci Adv 2022 06 10;8(23):eabm7981. Epub 2022 Jun 10.

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.

How basal cell carcinoma (BCC) interacts with its tumor microenvironment to promote growth is unclear. We use singe-cell RNA sequencing to define the human BCC ecosystem and discriminate between normal and malignant epithelial cells. We identify spatial biomarkers of tumors and their surrounding stroma that reinforce the heterogeneity of each tissue type. Read More

View Article and Full-Text PDF

Basal Cell Carcinoma: Pathology, Current Clinical Treatment, and Potential Use of Lipid Nanoparticles.

Cancers (Basel) 2022 Jun 3;14(11). Epub 2022 Jun 3.

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, nº. 228, 4050-313 Porto, Portugal.

Skin cancer is the most common type of carcinoma diagnosed worldwide, with significant morbidity and mortality rates among Caucasians, in particular basal cell carcinoma (BCC). The main risk factors of BCC are well-identified, and there are many chemotherapeutic drugs available for its treatment. The effectiveness of therapeutic options is governed by several factors, including the location of the tumor, its size, and the presence of metastases (although rare for BCC). Read More

View Article and Full-Text PDF

Immune Microenvironment of Muscular-Invasive Urothelial Carcinoma: The Link to Tumor Immune Cycle and Prognosis.

Cells 2022 05 31;11(11). Epub 2022 May 31.

Medical Laboratory CSD, 03022 Kyiv, Ukraine.

In this study, we investigated the relationship between the tumor immune microenvironment (TIME), histological differentiation and hypoxia in patients with muscular-invasive urothelial carcinomas (MIUC) after radical cystectomy. Forty-two cases of pT2-3N0M0 MIUCs underwent clinical, histological and immunohistochemical evaluation by counting CD8+, FOXP3+, CD68+, CD163+ cells and polymorphonuclear leukocytes (PMN) in intra-tumoral and peritumoral areas, assessing PD-L1 and GLUT1 expression for defining the impact of tumor immune contexture on patients' outcomes. Five-year survival rates and overall survival were calculated. Read More

View Article and Full-Text PDF

Preliminary results on a proposed histopathological assessment of predictive factors for basal cell carcinoma recurrence after primary free margin excision.

Skin Health Dis 2022 Jun 25;2(2):e88. Epub 2022 Mar 25.

Service of Pathology CHU Reims University Hospital of Reims Reims France.

Background: Basal cell carcinoma (BCC) incidence is steadily increasing but therapeutic solutions remain limited and present a public health challenge.

Aims: To identify predictive factors of BCC recurrence after primary free margin excision, with automated methods, by evaluating cell proliferation, the Hedgehog pathway activation and primary cilia.

Materials And Methods: This case-control study included 32 patients (16 with recurrence occurring at least 6 months after complete resection, and 16 without recurrence) who underwent surgery for BCC. Read More

View Article and Full-Text PDF