13,558 results match your criteria Pathology - Basal Cell Carcinoma


Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary-care centre.

Singapore Med J 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.

We retrospectively reviewed the clinical features, management and outcomes of patients diagnosed with basal cell carcinoma (BCC) of the vulva at the Gynaecological Cancer Centre, KK Women's and Children's Hospital, Singapore, between 1 January 2000 and 28 February 2014. Patients with vulvar BCC were identified from the cancer registry, and their medical records reviewed and analysed. A total of 11 patients with vulvar BCC were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11622/smedj.2019014DOI Listing
February 2019

S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 2: Treatment, Prevention and Follow-up.

J Dtsch Dermatol Ges 2019 Feb;17(2):214-230

Department of Dermatology, Mainz University Medical Center, Mainz, Germany.

Basal cell carcinoma (BCC) is the most common malignant tumor among fair-skinned individuals, and its incidence had been steadily rising in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 2 addresses issues such as proper risk stratification, the various therapeutic approaches, and prevention as well as follow-up of patients with basal cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ddg.13755
Publisher Site
http://dx.doi.org/10.1111/ddg.13755DOI Listing
February 2019
3 Reads

Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas.

Curr Health Sci J 2018 Apr-Jun;44(2):166-171. Epub 2018 Mar 27.

Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, Romania.

Basal cell carcinomas (BCCs) are malignant tumors with particular biological prognosis and behavior, and the biomolecular investigation of these lesions can provide important therapeutic targets for epithelial neoplasia. In this study we analyzed the immunoexpression of transforming growth factor beta 3 (TGFβ3) and its receptor type III (TGFβRIII) for 53 cases of BCC in relation to the main histopathological prognostic parameters. The results indicated statistically significant differences of TGFβ3 and TGFβRIII expression related to histological type and lesion stage, the both proteins being higher expressed in adenoid and morpheaform advanced stage tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12865/CHSJ.44.02.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320465PMC

Long-term recurrence rates of whole specimen intraoperative frozen section analysis in basal cell carcinomas of the face with WIFSA.

J Surg Oncol 2019 Feb 8. Epub 2019 Feb 8.

Department of Plastic Surgery and Hand Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.

Background And Objectives: Recent studies show that whole specimen intraoperative frozen section analysis (WIFSA) is a reliable method for margin analysis in basal cell carcinoma (BCC) and has low recurrence rates after five-years follow-up. There are no studies with longer follow-up. Our aim is to present long-term recurrence rates after WIFSA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25396DOI Listing
February 2019
1 Read

More than meets the eye.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Otolaryngology Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.

We report an extremely rare case of a hybrid tumour of the maxillary sinus. A 51-year-old man presented with a 6-week history of nasal congestion and epiphora. Radiological imaging demonstrated a maxillary sinus tumour, with extensive local invasion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2015-212000DOI Listing
February 2019
1 Read

Recent Advances in Pathology: The 2019 Annual Review Issue of the Journal of Pathology.

J Pathol 2019 Feb 8. Epub 2019 Feb 8.

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields and our intention is to provide comprehensive updates in specific areas of pathology in which there has been considerable recent progress. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/path.5255
Publisher Site
http://dx.doi.org/10.1002/path.5255DOI Listing
February 2019
5 Reads

Patterns of proliferation and apoptosis in different subtypes of basal cell carcinoma, adjacent epidermis, and recurrent forms.

An Bras Dermatol 2019 Jan-Feb;94(1):108-110

Dermatology Course, Department of Dermatology and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu (SP), Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/abd1806-4841.20198165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360986PMC
February 2018

Peritumoral clefting as a key feature in differentiating basal cell carcinoma from trichoblastoma through in-vivo reflectance confocal microscopy.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

Adnexal tumors represent one of the most troublesome differential diagnosis when dealing with skin lesions with clinical and dermoscopic criteria suggestive for basal cell carcinoma (BCC). Among these, benign follicular tumors, and in particular trichoblastoma and trichoepithelioma, deserve a special mention as BCC mimickers. These are benign tumors showing differentiation toward the outer follicular sheath. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15467DOI Listing
February 2019
10 Reads

Basal Cell Carcinoma Pathology Requests and Reports Are Lacking Important Information.

J Skin Cancer 2019 3;2019:4876309. Epub 2019 Jan 3.

Department of Dermatology, Jordan University of Science and Technology, P.O. Box 3030, Irbid, Jordan.

Introduction: Basal cell carcinoma (BCC) is the most common cancer affecting humans. Luckily it has negligible risk for metastasis; however it can be locally destructive to surrounding tissue. The diagnosis of this tumor relies on clinical and dermoscopic features; however confirmation requires biopsy and histologic examination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/4876309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335659PMC
January 2019
1 Read

Epigenetic regulation of iASPP-p63 feedback loop in cutaneous squamous cell carcinoma.

J Invest Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London E1 2AT, UK. Electronic address:

Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the UK. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-kB signalling pathways and has been documented as highly expressed in several types of human cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.01.020DOI Listing
January 2019
1 Read

Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma.

J Invest Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford CA, United States of America. Electronic address:

Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naïve tumors responsiveness to Smoothened inhibitors (Smo), resistance in advanced tumors remains frequent. While the resistant BCCs usually maintain HH pathway activation, squamous cell carcinomas with Ras/MAPK pathway activation also arise, with the molecular basis of tumor type and pathway selection still obscure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2018.11.035DOI Listing
January 2019

[Clinicopathological analysis of cervical basaloid squamous cell carcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):7-12

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.003DOI Listing
January 2019
8 Reads

Isolation, Characterization and Proliferation of Cancer Cells from Breast Cancer Patients.

Acta Inform Med 2018 Dec;26(4):240-244

Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.

Introduction: The most cases of cancer death, which are in the first rank among cancers suffered by women is breast cancer. The breast cancer therapy for patients has been done, but still not optimal, so it is necessary to understand the mechanism of therapy in model cell of breast cancer.

Aim: This study aim to develop an isolation technique of breast cancer cell from patients as a cancer cell model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5455/aim.2018.26.240-244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311122PMC
December 2018
3 Reads

Effect of Sentinel Node Biopsy in Clinically N0, BRAF V600E-Mutated, Small Papillary Thyroid Carcinoma: A Pilot Study.

Clin Nucl Med 2019 Jan 25. Epub 2019 Jan 25.

General Surgery Unit, Azienda Ospedaliera Universitaria Pisana.

Purpose: BRAF V600E mutation papillary thyroid cancer (PTC) is more aggressive with a higher risk of lymph node involvement and a poorer prognosis. Prior studies failed to demonstrate the superiority of prophylactic lymphadenectomy. We investigated the utility of additional radio-guided sentinel node biopsy (SNB). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002465DOI Listing
January 2019
1 Read

Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.

Cancer Cell 2019 Feb 24;35(2):177-190.e8. Epub 2019 Jan 24.

Division of Genome Biology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Molecular Oncology, The Jikei University Graduate School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. Electronic address:

ARID1A encodes an SWI/SNF chromatin-remodeling factor and is frequently mutated in various cancers. This study demonstrates that ARID1A-deficient cancer cells are specifically vulnerable to inhibition of the antioxidant glutathione (GSH) and the glutamate-cysteine ligase synthetase catalytic subunit (GCLC), a rate-limiting enzyme for GSH synthesis. Inhibition of GCLC markedly decreased GSH in ARID1A-deficient cancer cells, leading to apoptotic cell death triggered by excessive amounts of reactive oxygen species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2018.12.009DOI Listing
February 2019

Smad3 suppresses epithelial cell migration and proliferation via the clock gene Dec1, which negatively regulates the expression of clock genes Dec2 and Per1.

Am J Pathol 2019 Jan 18. Epub 2019 Jan 18.

Department of Pathology, Wakayama Medical University School of Medicine, Wakayama, Japan.

Smad3 has circadian expression; however, whether Smad3 affects the expression of clock genes is poorly understood. Here, we investigated the regulatory mechanisms between Smad3 and the clock genes Dec1, Dec2, and Per1. In Smad3 knockout mice, the amplitude of locomotor activity was decreased and Dec1 expression was decreased in the suprachiasmatic nucleus, liver, kidney, and tongue compared with control mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2019.01.006DOI Listing
January 2019
1 Read

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.

J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Institute for Hematopathology, Hamburg, Germany.

The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63 K5 progenitors which generate the K10 luminal cells of sebaceous ducts; and (ii) p63 K5 K7 progenitors which finally generate K7 adipophilin EMA sebocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14765DOI Listing
January 2019
2 Reads

Scalp basal cell carcinoma: A different entity?

Dermatol Ther 2019 Jan 18:e12828. Epub 2019 Jan 18.

Department of Pathology, Faculty of Medicine of the University of Porto, Porto, Portugal.

Basal cell carcinoma is the most frequent malignant neoplasm in white-skinned individuals. It develops in different body areas, including in the scalp, which is a unique anatomical region due to the high number of pilosebaceous follicles; the scalp is protected from UV exposure, a main risk factor for basal cell carcinoma development. Moreover, scalp basal cell carcinoma has been described as more aggressive and difficult to treat than other forms of basal cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12828DOI Listing
January 2019
1 Read

Cytokeratin expression in epidermal stem cells in skin adnexal tumors.

Oncol Lett 2019 Jan 8;17(1):927-932. Epub 2018 Nov 8.

Department of Pathology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

The expression levels of seven types of cytokeratin (CK) in different kinds of skin adnexal tumors were evaluated. One hundred and thirty-two patients with different kinds of skin adnexal tumors admitted and treated in the Department of Dermatology of Dongying People's Hospital from May 2013 to May 2015 were selected and underwent tissue section staining. Another 20 cases of normal skin were enrolled as the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2018.9679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312935PMC
January 2019
1 Read

Imaging features of uterine and ovarian fibromatosis in Nevoid Basal Cell Carcinoma Syndrome.

J Radiol Case Rep 2018 Sep 30;12(9):21-30. Epub 2018 Sep 30.

Department of Radiology, Azienda Ospedaliero-Universitaria Policlinico di Modena, Italy.

Gorlin-Goltz Syndrome also known as Nevoid Basal Cell Carcinoma Syndrome is an autosomal dominant multisystem disorder. It is characterized by basal cell carcinomas, odontogenic keratocysts, skeletal abnormalities and in a minority of female patients bilateral calcified ovarian fibromas. It is challenging to radiologically assess ovarian fibromas as they have similar imaging patterns to some malignant ovarian lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3941/jrcr.v12i9.3390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312044PMC
September 2018
1 Read

Tetrad presentation of non-syndromic odontogenic keratocyst: An uphill diagnostic and therapeutic challenge.

Dent Med Probl 2018 Oct-Dec;55(4):447-451

Department of Oral Pathology and Microbiology, the A.B. Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Deralakatte, India.

Odontogenic keratocyst (OKC), in the last decade sceptically referred to as keratocystic odontogenic tumor (KCOT), is known for its subclinical extensive growth potential and significant rate of recurrences. Odontogenic keratocyst, being the third most common cystic lesion (10-20%) of the maxillofacial region, is often recognized as a sporadic lesion and is well-documented in the literature. Multiple presentation of these cysts over a lifetime is relatively uncommon and is usually seen in conjunction with nevoid basal cell carcinoma syndrome (NBCC), orofacial digital syndrome, Noonan syndrome, Ehlers-Danlos syndrome, Simpson-Golabi-Behmel syndrome, or other syndromes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17219/dmp/96272DOI Listing
January 2019

Primary Cutaneous Angiosarcoma of the Eyelid: A Diagnostic and Therapeutic Challenge.

Ocul Oncol Pathol 2018 Jun 12;4(4):230-235. Epub 2018 Jan 12.

Department of Ophthalmic Pathology, Thomas Jefferson University, Philadelphia, PA, USA.

Primary cutaneous angiosarcoma is a rare vasoformative malignant neoplasm that can present a diagnostic and therapeutic challenge. We describe a 76-year-old Caucasian man with right upper eyelid swelling and nodularity, initially suspected clinically to represent either ocular adnexal lymphoma or basal cell carcinoma. Incisional biopsy and wide resection of the mass with frozen section control of margins were interpreted as compatible with hobnail (Dabska-retiform) hemangioendothelioma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322085PMC
June 2018
1 Read

Reconstruction of Mohs Defects Located in the Head and Neck.

J Craniofac Surg 2019 Jan 10. Epub 2019 Jan 10.

Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Background: Defects following Mohs micrographic surgery (MMS) can range in size from small defects requiring linear closure to large defects needing flap coverage. Reconstruction is dependent on defect size and facial aesthetic unit involvement. The aim of this study was to review the types of facial reconstruction per aesthetic unit involvement and describe their outcomes. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00001665-900000000-9509
Publisher Site
http://dx.doi.org/10.1097/SCS.0000000000005137DOI Listing
January 2019
5 Reads
0.676 Impact Factor

Melanoma Within Basal Cell Carcinoma Nests Discovered During Mohs Micrographic Surgery.

Dermatol Surg 2019 Jan 11. Epub 2019 Jan 11.

Bennett Surgery Center, Santa Monica, California Department of Pathology, Providence Saint John's Hospital, Santa Monica, California Bennett Surgery Center, Santa Monica, California Department of Medicine (Dermatology), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DSS.0000000000001762DOI Listing
January 2019
5 Reads

[Terebrant basal cell carcinoma].

Pan Afr Med J 2018 30;30:300. Epub 2018 Aug 30.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

Basal cell carcinoma (BCC) is the most frequent skin cancer. It never affects the mucosa. It is characterized by a local malignancy with an extremely rare risk of developing distant metastasis and the lowest mortality. Read More

View Article

Download full-text PDF

Source
http://www.panafrican-med-journal.com/content/article/30/300
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.300.16224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320449PMC
January 2019
3 Reads

Multiple facial plaque variant of trichoblastoma.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Departments of Dermatology and Pathology, Instituto Valenciano de Oncología, Valencia, Spain.

Background: The plaque variant of trichoblastoma has been described as a solitary tumor with diffuse infiltration of the lower dermis and hypodermis, with poorly defined borders. Herein, we report a new variant of multiple centrofacial trichoblastoma.

Object: To describe clinical and pathological features of a new multiple kind of plaque variant of centrofacial trichoblastoma. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13416
Publisher Site
http://dx.doi.org/10.1111/cup.13416DOI Listing
January 2019
2 Reads

Proliferative Activity in Basal Cell Carcinomas.

Curr Health Sci J 2018 Jan-Mar;44(1):55-60. Epub 2018 Jan 13.

Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.

Basal cell carcinomas (BCCs) represent one of the most common human neoplasias. The excellent prognosis of the diagnosed early lesions and the low metastasis rate are particularities that required the investigation of the mechanisms of carcinogenesis on these lesions. In this study we analyzed the proliferation rate for 53 cases of BCC in relation to the clinicopathological parameters of the lesions using Ki67, considered a true indicator of cellular proliferation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12865/CHSJ.44.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295187PMC
January 2018
1 Read

Epidemiological Aspects in Lip Tumors in Oltenia Region of Romania During 2012-2016.

Curr Health Sci J 2018 Jan-Mar;44(1):39-47. Epub 2018 Mar 21.

Oral Health Department, University of Medicine and Pharmacy of Craiova, Romania.

Purpose: The objective of this study was to review lip tumor diagnosed subjects from Oltenia region, in the past 5 years according to gender, age, home environment, profession, geographic area, smoking habit, associated diseases, tumor location, macroscopic aspect and histological type.

Material And Methods: The study was done at the Oral and Maxillo-Facial Clinic of the Emergency Clinical County Hospital of Craiova, and involved the analysis of patient file records, surgical registers, histopathological bulletins, from 2012-2016.

Results: Of the 175 subjects included in this study, all of them diagnosed with lip tumor pathology, 109 (62. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12865/CHSJ.44.01.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295190PMC
March 2018
1 Read

Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts.

Int J Oral Sci 2019 Jan 5;11(1). Epub 2019 Jan 5.

Department of Oral Pathology, Peking University School and Hospital of Stomatology, 22 South Zhongguancun Avenue, Haidian District, Beijing, China.

Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mutations (at ∼80%) are frequently detected in the epithelia of both NBCCS-related and sporadic OKCs, suggesting that PTCH1 inactivation might constitutively activate sonic hedgehog (SHH) signalling and play a major role in disease pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41368-018-0034-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320367PMC
January 2019
2 Reads
2.029 Impact Factor

Frequent TLE1 Expression in Cutaneous Neoplasms.

Am J Dermatopathol 2019 Jan;41(1):1-6

Dermatopathologist, Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001186DOI Listing
January 2019
2 Reads

Dermoscopic features of acral basal cell carcinoma.

Int J Dermatol 2019 Mar 3;58(3):e54-e55. Epub 2019 Jan 3.

Department of Pathology, Carlos Andrade Marín Hospital, Quito, Ecuador.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14375DOI Listing

Extensive bony metastases from facial metatypical basal cell carcinoma: a case report.

Br J Oral Maxillofac Surg 2019 Jan 28;57(1):82-84. Epub 2018 Dec 28.

Department of Oral- and Maxillofacial Surgery, Federal Armed Forces Hospital, Rübenacherstr. 170, 56072 Koblenz, Germany.

Metastatic basal cell carcinoma (BCC) is rare. We treated a 44-year-old woman with an extended facial metatypical BCC in whom staging showed no local or distant metastases, but one year after resection, we diagnosed a local recurrence. Re-staging, using a fludeoxyglucose positron emission tomography-computed tomogram, (FDG PET-CT) showed suspected accumulations of FDG in the whole axial skeleton. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjoms.2018.10.286DOI Listing
January 2019
1 Read

Expression of P53 Protein and Ki-67 Antigen in Oral Leukoplakia with Different Histopathological Grades of Epithelial Dysplasia.

J Int Soc Prev Community Dent 2018 Nov-Dec;8(6):513-522. Epub 2018 Nov 29.

Department of Oral Pathology and Microbiology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India.

Aims And Objective: The aim of this study is to investigate the expression of p53 protein and Ki-67 antigen in normal oral mucosa and oral leukoplakia with different grades of dysplasia using immunohistochemistry and to clarify the correlation of the expression of these cell cycle regulatory proteins.

Materials And Methods: A total of 20 archival tissue blocks obtained from our department which were diagnosed as mild ( = 5), moderate ( = 5), and severe dysplasia ( = 5) with normal mucosa ( = 5) as a control. Positivity of Ki-67 and p53 was analyzed using Statistical Package for the Social Sciences (IBM Corp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jispcd.JISPCD_241_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280575PMC
November 2018

S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 1: Epidemiology, Genetics and Diagnosis.

J Dtsch Dermatol Ges 2019 Jan 28;17(1):94-103. Epub 2018 Dec 28.

Department of Dermatology, Mainz University Medical Center, Mainz, Germany.

Basal cell carcinoma is the most common malignant tumor among fair-skinned individuals, and its incidence has been rising steadily in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 1 highlights new developments in genetics in particular as well as aspects regarding epidemiology, diagnosis, and histology. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ddg.13733
Publisher Site
http://dx.doi.org/10.1111/ddg.13733DOI Listing
January 2019
16 Reads

I seeds implantation for an elderly patient of skin squamous cell carcinomas with ulcer guided by ultrasound.

J Cancer Res Ther 2018 ;14(7):1660-1664

Department of Oncology, The Hebei General Hospital, Shijiazhuang, Hebei Province, China.

The skin squamous cell carcinoma (SCC) is a kind of malignancy of keratinocytes. SCC was originated within the epidermis or relevant appendages, which commonly occurred on sunlight exposure sites, such as the head and neck. This case report described an 85-year-old female patient with skin SCC at the right frontal, accompanied with skin ulcer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_1032_17DOI Listing
February 2019
1 Read

A Case Report of Basal Cell Carcinoma in a Non-Sun-Exposed Area: A Rare Presentation Mimicking Recurrent Perianal Abscess.

Case Rep Surg 2018 21;2018:9021289. Epub 2018 Nov 21.

Department of Surgery, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Basal cell carcinoma (BCC), a common malignancy, arises most often in sun-exposed areas but does rarely occur in non-sun-exposed sites. Prior tissue injury, especially sharp trauma and chronic inflammation, increases the risk of BCC. We describe a 66-year-old male patient with recurrent perianal abscesses who was found to have a large pigmented basal cell carcinoma. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/cris/2018/9021289/
Publisher Site
http://dx.doi.org/10.1155/2018/9021289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280225PMC
November 2018
3 Reads

Histologic subtype of treatment failures after noninvasive therapy for superficial basal cell carcinoma: An observational study.

J Am Acad Dermatol 2018 Dec 21. Epub 2018 Dec 21.

Department of Dermatology, Maastricht University Medical Center+, Maastricht, the Netherlands; GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, the Netherlands.

Background: There have been concerns that recurrences after noninvasive therapy for basal cell carcinoma (BCC) transform into a "more aggressive" histologic subtype.

Objective: We sought to evaluate the proportion of patients with a nonsuperficial treatment failure after noninvasive therapy for superficial BCC.

Methods: An observational study was performed using data from a single blind, noninferiority, randomized controlled trial (March 2008-August 2010) with 5-year follow-up in patients with primary superficial BCC treated with methylaminolevulinate-photodynamic therapy, 5-fluorouracil, or imiquimod. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01909622183310
Publisher Site
http://dx.doi.org/10.1016/j.jaad.2018.12.028DOI Listing
December 2018
3 Reads

Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome.

Oncogene 2018 Dec 21. Epub 2018 Dec 21.

INSERM UMR 1149, Centre de Recherche sur l'Inflammation, Paris, France.

Metabolic syndrome (MS) is becoming the leading risk factor for hepatocellular carcinoma (HCC). HCC development related to MS may occur in advanced or non-advanced liver fibrosis, suggesting specific molecular pathways. Among these pathways, basal inflammatory state and adipokines production are involved. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41388-018-0597-1
Publisher Site
http://dx.doi.org/10.1038/s41388-018-0597-1DOI Listing
December 2018
5 Reads

An Unusual Case of Medullary Thyroid Carcinoma and A Revision of Current Literature.

Endocr Metab Immune Disord Drug Targets 2019 ;19(2):226-229

Endocrinology and Metabolism Unit, University-Hospital "Santa Maria della Misericordia", Udine, Italy.

Background: Medullary thyroid cancer (MTC) accounts for 5% of all thyroid cancers and occurs either sporadically or in a hereditary pattern. Routine calcitonin (CT) measurement is suggested for MTC screening in patients with nodular thyroid disease.

Patient Findings: A 45 years-old woman incidentally discovered, with neck ultrasound, the presence of thyroid micronodules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871530319666181220165350DOI Listing
January 2019
3 Reads

Risks for lymphoma and gastrointestinal carcinoma in patients with newly diagnosed adult-onset celiac disease: Consequences for follow-up: Celiac disease, lymphoma and GI carcinoma.

United European Gastroenterol J 2018 Dec 12;6(10):1485-1495. Epub 2018 Sep 12.

Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands.

Background: The association between celiac disease (CD) and the development of lymphoid and gastrointestinal (GI) malignancies have been reported. However, data are scarce yet needed to develop evidence-based follow-up programs.

Objective: The objective of this article is to assess relative (RR) and absolute risks of lymphoma and GI carcinoma for newly diagnosed patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050640618800540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297918PMC
December 2018
1 Read

Solitary pulmonary metastasis from a gingival cancer of 36 years ago: A case report.

Int J Surg Case Rep 2018 24;53:436-440. Epub 2018 Nov 24.

Departments of General Thoracic Surgery, Seirei Hamamatsu General Hospital, Japan.

Introduction: Unlike a squamous cell carcinoma (SqCC), an adenoid cystic carcinoma (ACC) is an uncommon histology of all head and neck cancers. The clinical significance of a pulmonary metastasectomy differs greatly between these two types of cancers. A solitary pulmonary nodule in a patient with a history of both these different malignancies is a diagnostic and therapeutic challenge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2018.11.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262786PMC
November 2018
1 Read

Margin-Controlled, Staged Surgical Excision in the Treatment of High-Risk Basal Cell Carcinomas of the Head and Neck Region.

J Cutan Med Surg 2018 Dec 17:1203475418820868. Epub 2018 Dec 17.

2 Department of Plastic Reconstructive and Aesthetic Surgery, Marmara University School of Medicine, Istanbul, Turkey.

Background:: The most common skin cancer is basal cell carcinoma (BCC), and the gold-standard treatment for high-risk tumours is Mohs surgery. However, alternative methods are needed for high-risk tumours in countries where the performance rate of Mohs surgery is low.

Objectives:: The objective of this article is to investigate the feasibility, efficacy, and safety of margin-controlled, staged surgical excision (MCSSE) in high-risk tumours as a possible treatment alternative. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1203475418820868DOI Listing
December 2018
9 Reads

Keratinocyte Carcinomas: Current Concepts and Future Research Priorities.

Clin Cancer Res 2018 Dec 6. Epub 2018 Dec 6.

Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are keratinocyte carcinomas, the most frequently diagnosed cancers in fair-skinned populations. Ultraviolet radiation (UVR) is the main driving carcinogen for these tumors, but immunosuppression, pigmentary factors, and aging are also risk factors. Scientific discoveries have improved the understanding of the role of human papillomaviruses (HPV) in cSCC as well as the skin microbiome and a compromised immune system in the development of both cSCC and BCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-1122DOI Listing
December 2018
12 Reads
8.722 Impact Factor

Malignant eyelid tumors: Are intra-operative rapid frozen section and permanent section diagnoses of surgical margins concordant?

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Ophthalmic Pathology Laboratory (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors.

Methods: This is a retrospective study of 120 cases and 429 frozen section slides.

Results: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-018-1058-0DOI Listing
December 2018
2 Reads

Basal cell carcinoma and basosquamous carcinoma, two faces of the same condition?

Rom J Morphol Embryol 2018 ;59(3):989-996

Department of Microscopic Morphology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania; Department of Otorhinolaryngology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

Basal cell carcinoma (BCC) is the most common locally invasive malignant epidermal neoplasm. It is generally a tumor that runs a slow progressive course and can usually be cured by surgery. Basosquamous carcinoma is considered by some authors a rare subtype of BCC, while others describe it as independent tumor with different evolution from BCC. Read More

View Article

Download full-text PDF

Source
January 2019
5 Reads

Mixed (nodular and morpheic) upper eyelid basal cell carcinoma with orbital invasion - histological and clinical features.

Rom J Morphol Embryol 2018 ;59(3):977-983

Department of Plastic Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Read More

View Article

Download full-text PDF

Source
January 2019
6 Reads

The prognostic value of CXCR4, α-SMA and WASL in upper lip basal cell carcinomas.

Rom J Morphol Embryol 2018 ;59(3):839-849

Department of Dental Materials, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania;

Lip cancers account for 10-12% of the total head and neck cancers and, although squamous cell carcinoma is by far the most common lower lip cancer, the basal cell carcinoma (BCC) seems to be more common for the upper lip. Most BCCs have a clinically indolent behavior, but there are also local aggressive and∕or metastatic cases, with the incidence of such cases being estimated at about 1-10% of all cases of BCC. Many of the molecular mechanisms underlying this aggression are still unknown, which is why our study aimed to investigate the potential prognosis of a few markers, such as C-X-C chemokine receptor type 4 (CXCR4), alpha-smooth muscle actin (α-SMA) and Wiskott-Aldrich syndrome like (WASL) in upper lip BCCs. Read More

View Article

Download full-text PDF

Source
January 2019
8 Reads

Curettage and multiple needle puncture-assisted methyl-aminolaevulinate photodynamic therapy of basal cell carcinoma.

Eur J Dermatol 2018 Dec;28(6):818-822

University of Northern Norway, Institute of Clinical Medicine, Tromsø, Norway, Lillehammer Dermatological Clinic, Lillehammer, Norway.

The use of skin puncture techniques may facilitate the delivery of topically applied drugs for photodynamic therapy (PDT). The main aim of this prospective study was to evaluate the efficacy and cosmetic outcome of curettage, multiple needle puncture, and methyl-aminolaevulinate (MAL)-PDT in basal cell carcinoma (BCC). All tumours received curettage and 15-20 needle punctures/cm before two sessions of MAL-PDT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2018.3445DOI Listing
December 2018
1 Read

Non-genetic and genetic predictors of a superficial first basal cell carcinoma.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Several observational studies have suggested differences in the risk factor profile between patients with superficial basal cell carcinomas (BCCs) and non-superficial BCCs.

Objective: To test the reproducibility of previous study findings and to find new genetic and non-genetic predictors for patients with a superficial first BCC.

Methods: A total of 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15389DOI Listing
December 2018
3 Reads

Mass spectrometric imaging of cysteine rich proteins in human skin.

Int J Biol Macromol 2019 Mar 2;125:270-277. Epub 2018 Dec 2.

Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. Electronic address:

Looking insight pathological processes, metallothioneins (MTs) are considered to be potential biomarkers for monitoring of a development of various types of diseases, such as cancer. The early identification of the MTs in biological tissues could be important tool for the estimation of appropriate clinical therapy. Therefore, here we investigated the application of matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) together with immunohistochemical analyses (IHC) using MT-1/2 antibody for MT detection in formalin-fixed paraffin-embedded (FFPE) biopsy specimens of human skin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2018.11.272DOI Listing
March 2019
10 Reads