14,313 results match your criteria Pathology - Basal Cell Carcinoma


Junctional Melanocytic Hyperplasia Overlying Benign Fibrous Papule: An Under-recognized Variant of a Common Lesion.

J Cutan Pathol 2020 Jun 4. Epub 2020 Jun 4.

Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Fibrous papule (angiofibroma) is a common benign tumor often presenting as an erythematous papule on the face of an adult, most commonly on the nose. The clinical differential diagnosis is often fibrous papule, basal cell carcinoma, or intradermal nevus. A number of histologic variants of fibrous papule are described, including a variant with junctional melanocytic hyperplasia that can resemble lentigo maligna. Read More

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http://dx.doi.org/10.1111/cup.13767DOI Listing

A rare collision tumor of basal cell carcinoma and cherry angioma with dermoscopic and dermatopathological findings.

Dermatol Ther 2020 Jun 4:e13760. Epub 2020 Jun 4.

Department of Pathology, Hacettepe University, School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/dth.13760DOI Listing

miR-18a expression in basal cell carcinoma and regulatory mechanism on autophagy through mTOR pathway.

Clin Exp Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.

Background: Basal cell carcinoma (BCC) is the most common form of skin carcinoma.

Objective: To investigate the function of key miRNA and explore the potential molecular mechanisms involved in BCC.

Methods: Microarray dataset GSE34535 (including seven BCC samples and seven control samples) was downloaded from Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.1111/ced.14322DOI Listing

Basal cell carcinoma stroma as a mimicker of lymphatic invasion: A case report.

SAGE Open Med Case Rep 2020 29;8:2050313X20919602. Epub 2020 Apr 29.

Department of Dermatology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.

Basal cell carcinoma metastases are rare. We report a case of an 83 year-old male with recurrent cutaneous infiltrative basal cell carcinoma on the right vertex with tumor aggregates of infiltrative basal cell carcinoma in the lymphatic vessels of the superficial dermis strongly suspected on pathology slide evaluation during Mohs micrographic surgery. D2-40 immunohistochemical stain allows the detection of lymphatic invasion by highlighting endothelial cells. Read More

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http://dx.doi.org/10.1177/2050313X20919602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234329PMC

Navigated tissue characterization during skin cancer surgery.

Int J Comput Assist Radiol Surg 2020 May 31. Epub 2020 May 31.

School of Computing, Queen's University, Kingston, ON, Canada.

Purpose: Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer and is treated by surgical resection. Incomplete tumor removal requires surgical revision, leading to significant healthcare costs and impaired cosmesis. We investigated the clinical feasibility of a surgical navigation system for BCC surgery, based on molecular tissue characterization using rapid evaporative ionization mass spectrometry (REIMS). Read More

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http://dx.doi.org/10.1007/s11548-020-02200-4DOI Listing

Association of Multiple Aggregated Yellow-White Globules With Nonpigmented Basal Cell Carcinoma.

JAMA Dermatol 2020 May 27. Epub 2020 May 27.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Basal cell carcinoma (BCC) is the most common skin cancer. Dermoscopic imaging has improved diagnostic accuracy; however, diagnosis of nonpigmented BCC remains limited to arborizing vessels, ulceration, and shiny white structures.

Objective: To assess multiple aggregated yellow-white (MAY) globules as a diagnostic feature for BCC. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.1450DOI Listing

A New Look at the History of Peripheral Ameloblastoma.

Head Neck Pathol 2020 May 25. Epub 2020 May 25.

Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.

Peripheral ameloblastoma (PA) is a prototype form of extraosseous odontogenic tumor. As knowledge of PA has accumulated on the basis of more than 200 cases reported worldwide over a 60-year timeframe, it is important to comprehend the historical evolution of this entity. In 2018, we summarized the American history of PA, stressing the important early strides made by Bloodgood in 1904 with his many original observations of the "epulis form of ameloblastoma". Read More

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http://dx.doi.org/10.1007/s12105-020-01168-6DOI Listing

Kidney Transplant Modifies the Architecture and Microenvironment of Basal Cell Carcinomas.

Kidney Blood Press Res 2020 20;45(3):368-377. Epub 2020 May 20.

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania L. Vanvitelli, Naples, Italy.

Background/aims: Basal cell carcinoma (BCC) is a frequent type of nonmelanoma skin cancer, which shows a greater prevalence in kidney-transplanted (KT) patients than in the general population. The study of this tumor in KT patients may allow us to understand the influence of the tumor inflammatory microenvironment on cancer behavior, and to design new image analysis methods to determine prognosis and apply personalized medicine. The major hypothesis of the present work is that antirejection drugs, by modifying the B-cell/T-cell balance, induce measurable differences in tumoral cell microarchitecture and in the inflammatory microenvironment in KT patients compared to nontransplanted controls. Read More

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http://dx.doi.org/10.1159/000507581DOI Listing

Seborrheic Keratosis Concealing a Basal Cell Carcinoma.

Ophthalmic Plast Reconstr Surg 2020 May 19. Epub 2020 May 19.

Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, and.

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http://dx.doi.org/10.1097/IOP.0000000000001706DOI Listing

Chronic Venous Insufficiency As A Predisposing Factor For Basal Cell Carcinoma On Legs.

Ann Vasc Surg 2020 May 15. Epub 2020 May 15.

Medical School, Unicamp, Departments of Pathology. Electronic address:

Background: The main risk factor associated with basal cell carcinoma (BCC) is believed to be exposure to ultraviolet radiation (UVR). In the case of lower limb BCC, the frequency is higher in women, possibly because of greater leg UVR exposure. Chronic venous insufficiency (CVI), also more common in women, may have some association with leg BCC. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.04.053DOI Listing

Successful Treatment of Topical Imiquimod-resistant Basal Cell Carcinoma by Electronic X-ray Brachytherapy.

Dermatol Ther 2020 May 17:e13609. Epub 2020 May 17.

Department of Dermatology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1111/dth.13609DOI Listing

Dermoscopic features and differential diagnosis of sebaceous carcinoma.

J Dermatol 2020 May 16. Epub 2020 May 16.

Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.

Sebaceous carcinoma is a rare malignant skin neoplasm arising from sebaceous glands. Its clinical diagnosis is difficult and reports of dermoscopic findings have been limited. This study aims to analyze its dermoscopic features and differential diagnosis in dermoscopic examination. Read More

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http://dx.doi.org/10.1111/1346-8138.15384DOI Listing

A story of a pimple: Newly diagnosed chronic lymphocytic leukemia in a basal cell carcinoma biopsy.

J Cutan Pathol 2020 May 16. Epub 2020 May 16.

Department of Pathology, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1111/cup.13745DOI Listing

An unusual cause of a common presentation: a case of metastatic basal cell carcinoma.

Br J Oral Maxillofac Surg 2020 May 11. Epub 2020 May 11.

Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield. Electronic address:

Metastasis of basal cell carcinoma is exceedingly rare and usually not considered in the differential diagnosis of neck lumps. We present a case highlighting the importance of a thorough history and consideration of metastatic basal cell carcinoma in patients with a basaloid metastasis and an unknown primary. Read More

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http://dx.doi.org/10.1016/j.bjoms.2020.04.037DOI Listing

Sebaceous carcinoma and basal cell carcinoma arising within nevus sebaceous on the face-A rare entity with dermatoscopic findings.

Dermatol Ther 2020 May 13:e13576. Epub 2020 May 13.

Department of Dermatology, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/dth.13576DOI Listing

CK14 Expression Identifies a Basal/Squamous-Like Type of Papillary Non-Muscle-Invasive Upper Tract Urothelial Carcinoma.

Front Oncol 2020 24;10:623. Epub 2020 Apr 24.

Department of Pathology, Seoul National University Hospital, Seoul, South Korea.

CK14 expression is an important marker of basal/squamous-like (BASQ)-type muscle-invasive bladder carcinoma, and this molecularly defined subtype has a poor prognosis and a distinct response to chemotherapy. However, CK14 expression and its clinicopathological and molecular significance in papillary non-muscle-invasive upper tract urothelial carcinoma (NMIUTUC) remain unknown. Herein, we investigated the prognostic implications of immunohistochemical (IHC) staining for CK14 and the transcriptional characteristics associated with CK14 expression in papillary NMIUTUC. Read More

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http://dx.doi.org/10.3389/fonc.2020.00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193093PMC

Greater utility of molecular subtype rather than epithelial-to-mesenchymal transition (EMT) markers for prognosis in high-risk non-muscle-invasive (HGT1) bladder cancer.

J Pathol Clin Res 2020 May 6. Epub 2020 May 6.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.

Approximately 75% of bladder cancers are non-muscle invasive (NMIBC). Of these, up to 53% of cases progress to life-threatening muscle-invasive bladder cancer (MIBC). Patients with high-grade stage T1 (HGT1) NMIBC frequently undergo radical cystectomy (RC), although this represents overtreatment for many. Read More

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http://dx.doi.org/10.1002/cjp2.167DOI Listing

Cumulative risk of skin cancer in patients with Li-Fraumeni syndrome.

Fam Cancer 2020 Apr 30. Epub 2020 Apr 30.

Department of Dermatology, Netherlands Cancer Institute, Plesmanlaan 12, 1066, CX, Amsterdam, The Netherlands.

Li-Fraumeni syndrome (LFS) is an inherited cancer syndrome, characterized by an early onset of various types of cancers. LFS is associated with a germline mutation in the TP53 gene. The risk of developing skin cancer in patients with LFS is unknown. Read More

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http://dx.doi.org/10.1007/s10689-020-00178-1DOI Listing

Peritumoral Clefting and Expression of MMP-2 and MMP-9 in Basal Cell Carcinoma of the Skin.

In Vivo 2020 May-Jun;34(3):1271-1275

School of Medicine, University of Zagreb, Zagreb, Croatia

Background/aim: Peritumoral clefting is one of the main histologic features of basal cell carcinoma of the skin (BCC). The aim of the study was to analyze the expression of MMP-2 and MMP-9 both in cells of basal cell carcinoma and in the adjacent stroma and to correlate the findings of immunohistochemical analysis with the presence of peritumoral clefting.

Patients And Methods: The study was made on archival material comprising 48 cases of BCC. Read More

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http://dx.doi.org/10.21873/invivo.11901DOI Listing

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.

Vet Comp Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. Read More

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http://dx.doi.org/10.1111/vco.12604DOI Listing

Trp53 mutation in Krt5-expressing basal cells facilitates the development of basal squamous-like invasive bladder cancer in the chemical carcinogenesis of mouse bladder.

Am J Pathol 2020 Apr 24. Epub 2020 Apr 24.

Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

The biological processes of urothelial carcinogenesis are not fully understood, particularly regarding the relationship between specific genetic events, cell of origin, and molecular subtypes of subsequent tumors. N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced mouse bladder cancer is widely accepted as a useful model that recapitulates the pathway of human bladder tumorigenesis from dysplasia to invasive cancer via carcinoma in situ. However, the long and variable time of tumorigenesis often hinders efficient preclinical or translational research. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.04.005DOI Listing

Perioperative margin detection in basal cell carcinoma using a deep learning framework: a feasibility study.

Int J Comput Assist Radiol Surg 2020 May 22;15(5):887-896. Epub 2020 Apr 22.

School of Computing, Queen's University, Kingston, ON, Canada.

Purpose: Basal cell carcinoma (BCC) is the most commonly diagnosed cancer and the number of diagnosis is growing worldwide due to increased exposure to solar radiation and the aging population. Reduction of positive margin rates when removing BCC leads to fewer revision surgeries and consequently lower health care costs, improved cosmetic outcomes and better patient care. In this study, we propose the first use of a perioperative mass spectrometry technology (iKnife) along with a deep learning framework for detection of BCC signatures from tissue burns. Read More

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http://dx.doi.org/10.1007/s11548-020-02152-9DOI Listing

Surgery versus combined treatment with Curettage and Imiquimod for Nodular basal cell carcinoma (SCIN): 1-year results of a non-inferiority, randomized controlled trial.

J Am Acad Dermatol 2020 Apr 19. Epub 2020 Apr 19.

Department of Epidemiology, Maastricht University, Maastricht, The Netherlands; Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands; GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Purpose: Nodular basal cell carcinoma (nBCC) is mostly treated with surgical excision. Interest in minimally invasive treatment of these low-risk tumors is increasing. We assessed the effectiveness of nBCC treatment with curettage and imiquimod cream compared to surgical excision. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.053DOI Listing

Myeloid cell-derived TGF-beta signaling regulates ECM deposition in mammary carcinoma via adenosine-dependent mechanisms.

Cancer Res 2020 Apr 20. Epub 2020 Apr 20.

Medicine, Vanderbilt University Medical Center

TGFβ plays a crucial role in the tumor microenvironment by regulating cell-cell and cell-stroma interactions. We previously demonstrated that TGFβ signaling on myeloid cells regulates expression of CD73, a key enzyme for production of adenosine, a pro-tumorigenic metabolite implicated in regulation of tumor cell behaviors, immune response, and angiogenesis. Here, using an MMTV-PyMT mouse mammary tumor model, we discovered that deletion of TGFβ signaling on myeloid cells (PyMT/TGFβRIILysM) affects ECM formation in tumor tissue, specifically increasing collagen and decreasing fibronectin deposition. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-19-3954DOI Listing

Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.

J Cell Mol Med 2020 Apr 19. Epub 2020 Apr 19.

Department of Pathology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Finding out the driver gene critical for the maintenance of breast cancer stem cells (BrCSCs) is important for designing a new strategy to eradicate these cells to improve patient's prognosis. Here, in our study, we revealed that PIM1, an oncogenic serine-threonine kinase and a well-proven contributor to the tumorigenesis of breast cancer, was involved in BrCSCs regulation and promised to be a new target for eradicating BrCSCs. In brief, PIM1 could enhance the stem cell-like traits of breast cancer cells by promoting the phosphorylation and cytoplasmic localization of RUNX3. Read More

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http://dx.doi.org/10.1111/jcmm.15272DOI Listing

BerEP4 positivity in Merkel cell carcinoma: a potential diagnosis pitfall.

J Eur Acad Dermatol Venereol 2020 Apr 17. Epub 2020 Apr 17.

Department of Pathology, Université de Tours, CHU de Tours, avenue de la République, 37170, Chambray-les-tours, France.

Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin with a 5-year overall survival estimated at 40% . In 2008, Merkel cell Polyomavirus (MCPyV) integration was identified as the primary oncogenic event of about 80% of MCC cases. Under microscopic examination, MCC appears as a proliferation of basaloid tumor cells invading the dermis and subcutaneous tissues. Read More

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http://dx.doi.org/10.1111/jdv.16482DOI Listing

Surgical margins required for basal cell carcinomas treated with Mohs micrographic surgery based on tumor features.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Epiphany Dermatology, Dallas, TX. Electronic address:

Background: Basal cell carcinomas (BCC) with high-risk features are preferably treated by Mohs micrographic surgery (MMS). Studies have shown clinicopathologic characteristics that may predict more stages required for clearance. However, few studies have correlated such factors with the number of millimeters removed per stage. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.008DOI Listing

Risk of melanoma following keratinocyte malignancies.

Int J Cancer 2020 Apr 14. Epub 2020 Apr 14.

Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

Patients diagnosed with keratinocyte cancer experience heightened risk for melanoma, yet patients who go on to develop this malignancy have not been well-characterized. We followed a population-based cohort of 2243 participants with histologically confirmed KC identified from dermatology and pathology practices who did not have a history of internal malignancy (1363 BCC, 880 SCC). A total of 77 participants went on to develop melanoma. Read More

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http://dx.doi.org/10.1002/ijc.33011DOI Listing

Wide area digital dermoscopy applied to basal cell carcinoma.

An Bras Dermatol 2020 May - Jun;95(3):379-382. Epub 2020 Mar 20.

Department of Dermatology, Hospital Santa Casa de Misericórdia de Curitiba, Curitiba, PR, Brazil.

In situations in when a dermoscopic record of a large lesion is desirable, the resulting images are usually restricted to a small field of view due to the limited diameter of dermatoscope lenses. This limitation often produces several photographs separately, thus losing the possibility of a single-image global evaluation. In these case reports, we show examples of a recently published image montage technique called Wide Area Digital Dermoscopy, in this case, applied to basal cell carcinomas. Read More

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http://dx.doi.org/10.1016/j.abd.2019.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253909PMC

Expression of the immune checkpoint VISTA in breast cancer.

Cancer Immunol Immunother 2020 Apr 7. Epub 2020 Apr 7.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

V-domain Ig suppressor of T cell activation (VISTA) is a novel immune checkpoint that is an emerging target for cancer immunotherapy. This study aimed to investigate the expression of VISTA and its association with clinicopathologic parameters as weNll as with the key immune markers including programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1) in invasive ductal carcinoma (IDC) of the breast. Immunohistochemistry was used to detect VISTA, PD-1, PD-L1, and CD8 in tissue microarrays from 919 patients with IDC (N = 341 in the exploratory cohort and  = 578 in the validation cohort). Read More

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http://dx.doi.org/10.1007/s00262-020-02554-3DOI Listing

Nasal prosthesis after partial rhinectomy. A case report.

Clin Pract 2020 Mar 31;10(1):1200. Epub 2020 Mar 31.

Department Of Prosthodontics, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital, Nagpur, India.

Maxillofacial defects can result from several reasons, including neoplasia, congenital malformations, trauma, oral infections, etc. This kind of defects can be severely debilitating to the patients. To improve the quality of life of these patients, the options include surgical reconstruction and maxillofacial prosthesis. Read More

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http://dx.doi.org/10.4081/cp.2020.1200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132139PMC

A tender pigmented papule in an African-American woman.

JAAD Case Rep 2020 Apr 24;6(4):260-262. Epub 2020 Mar 24.

Department of Medicine, Division of Dermatology, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2020.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109375PMC

Regression of Periocular Basal Cell Carcinoma: A Report of Four Cases with Clinicopathologic Correlation.

Ocul Oncol Pathol 2020 Mar 28;6(2):107-114. Epub 2019 Aug 28.

Division of Ophthalmic Pathology, Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.

Objectives: To describe the spectrum of clinical and histopathological features of a case series of basal cell carcinoma (BCC) with spontaneous regression and to discuss this phenomenon.

Method: Four cases of BCC with complete/substantial regression were retrospectively identified. Patients' records were analyzed for demographic data, clinical appearance, and the postoperative course. Read More

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http://dx.doi.org/10.1159/000501370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109437PMC

Keratin 36, a specific marker of tongue filiform papillae, is downregulated in squamous cell carcinoma of the mobile tongue.

Mol Clin Oncol 2020 May 26;12(5):421-428. Epub 2020 Feb 26.

Department of Medical Biosciences, Umea University, SE-901 85 Umea, Sweden.

Human keratin 36 (K36) is a member of the hair keratin family and is a marker of hair cortex differentiation. The human gene is located on the long arm of chromosome 17 and belongs to the cluster of structurally unrelated acidic hair keratins. Recently, it has been reported that mRNA is specifically expressed in normal tongue epithelium and downregulated in squamous cell carcinomas of the mobile tongue. Read More

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http://dx.doi.org/10.3892/mco.2020.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087467PMC

The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.

Cells 2020 Apr 2;9(4). Epub 2020 Apr 2.

Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Read More

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http://dx.doi.org/10.3390/cells9040857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226813PMC

Local recurrence of clinically observed basal cell carcinomas following complete saucerization or punch removal with negative margins: retrospective case series from 2010 to 2020.

J Am Acad Dermatol 2020 Mar 28. Epub 2020 Mar 28.

Dermatology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Department of Dermatology, Stanford University Medical Center, Stanford, California. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.03.061DOI Listing

Clues to primary vismodegib resistance lie in histology and genetics.

J Clin Pathol 2020 Mar 26. Epub 2020 Mar 26.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA

Basal cell carcinoma (BCC) is the most common human malignant neoplasm. However, there are multiple BCC subtypes that share clinical features while demanding different management. We present a case of a woman with hundreds of BCCs throughout her body that were resistant to vismodegib and without other features of basal cell nevus syndrome. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206448DOI Listing
March 2020
2.915 Impact Factor

Anatomic Features of Head and Neck Keratinocyte Cancer in Virginia.

Dermatol Surg 2020 Mar 18. Epub 2020 Mar 18.

Departments of Oculoplastic Surger, and.

Background: Keratinocyte cancer (KC) patients benefit from early diagnosis. We describe here the anatomy of head/neck KCs to help guide screening efforts.

Objective: To examine lesion frequency and anatomic distribution of head and neck KC. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002370DOI Listing

Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status.

Mod Pathol 2020 Mar 20. Epub 2020 Mar 20.

Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be stratified into two prognostically relevant groups based on human papillomavirus (HPV) status. The prognostic value of p53 for further sub-stratification, particularly in the HPV-independent group, has not been agreed upon. This disagreement is likely due to tremendous variations in p53 immunohistochemical (IHC) interpretation. Read More

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http://dx.doi.org/10.1038/s41379-020-0524-1DOI Listing
March 2020
6.187 Impact Factor

Basaloid squamous cell carcinoma of the breast.

Rev Esp Patol 2020 Apr - Jun;53(2):113-116. Epub 2020 Jan 14.

Department of Pathology, Hospital Quironsalud Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Infections and Cancer Unit, Cancer Epidemiology Research Program, IDIBELL, Institut Català d'Oncologia (ICO)-IDIBELL, CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain.

Basaloid squamous cell carcinoma (BSCC) is a subtype of squamous cell carcinoma that characteristically occurs in the head and neck, may be related to HPV infection and is usually considered to be aggressive. We present the first description of BSCC of the breast. The tumor exhibited characteristic histologic features of BSCC, including nests of basaloid squamous cells with comedonecrosis, abrupt keratinization, and abundant hyaline basement membrane-like material deposition. Read More

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http://dx.doi.org/10.1016/j.patol.2019.10.003DOI Listing
January 2020

Hexyl aminolevulinate, 5-aminolevulinic acid nanoemulsion, and methyl aminolevulinate in photodynamic therapy of non-aggressive basal cell carcinomas: A non-sponsored, randomized, prospective and double-blinded trial.

J Eur Acad Dermatol Venereol 2020 Mar 20. Epub 2020 Mar 20.

Departments of Pathology and Dermatology, Institutes of Biomedicine and Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.

Background: In the photodynamic therapy (PDT) of non-aggressive basal cell carcinomas (BCCs), 5-aminolevulinic acid nanoemulsion (BF-200ALA) has shown non-inferior efficacy when compared with methyl aminolevulinate (MAL), a widely used photosensitizer. Hexyl aminolevulinate (HAL) is an interesting alternative photosensitizer. To our knowledge, this is the first study using HAL-PDT in the treatment of BCCs. Read More

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http://dx.doi.org/10.1111/jdv.16357DOI Listing

Basal cell carcinoma or melanoma, that is the question!

J Eur Acad Dermatol Venereol 2020 Mar 17. Epub 2020 Mar 17.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

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http://dx.doi.org/10.1111/jdv.16373DOI Listing

Immunohistochemical staining of podoplanin is helpful in determining the microinvasion of cervical squamous cell carcinoma.

Ann Diagn Pathol 2020 Mar 3;46:151493. Epub 2020 Mar 3.

Department of Pathology, School of Medicine, Shandong University, Jinan, Shandong, China; Department of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address:

Cervical squamous cell carcinoma develops through a series of stages, including low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), microinvasive squamous cell carcinoma (MISCC), and invasive squamous cell carcinoma (ISCC). The difference between HSIL and MISCC is the appearance of microinvasion, which determines the treatment for patients. However, sometimes it is difficult to differentiate HSIL from MISCC in morphology, and no effective markers are available to help determine microinvasion. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151493DOI Listing

Granuloma faciale arising on a scar after Mohs surgery for basal cell carcinoma.

J Cosmet Dermatol 2020 Mar 16. Epub 2020 Mar 16.

Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1111/jocd.13365DOI Listing

When to suspect a non-melanoma skin cancer.

BMJ 2020 Mar 11;368:m692. Epub 2020 Mar 11.

Department of Dermatology, Nottingham NHS Treatment Centre, Nottingham NG7 2FT, UK.

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http://dx.doi.org/10.1136/bmj.m692DOI Listing

Pilomatrix carcinoma of the lacrimal caruncle: a case report.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):153-156

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

A 45-year-old man presented with a 3-month history of a mass located in the caruncle of his right eye. An incisional biopsy had been performed one month prior by another specialist, and the histopathology report showed basal cell carcinoma. The mass was completely excised with a 2 mm safety margin, and the large conjunctival defect was reconstructed with one sheet of amniotic membrane allograft. Read More

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http://dx.doi.org/10.5935/0004-2749.20200029DOI Listing

Surgical Outcomes of More Than 1300 Cases of Mohs Micrographic Surgeries from a Private Mohs Clinic in Romania.

Chirurgia (Bucur) 2020 Jan-Feb;115(1):69-79

Basal cell carcinoma (BCC) and Squamous cell carcinoma (SCC) are the most frequent skin cancers with a continuous increasing incidence and a cause of economic impact. Mohs micrographic surgery (MMS) is known as the gold-standard of treatment of non-melanoma skin cancer. The files of the patients treated with MMS were analysed during a 6 year period (2014-2019) and demographic information was extracted in addition to the information on tumor histology, localization of tumors, number of stages required for a complete removal of the tumors, and the evolution of the patients. Read More

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http://dx.doi.org/10.21614/chirurgia.115.1.69DOI Listing

[Skin cancers in Madagascar: where do we stand?]

Pan Afr Med J 2019 29;34:167. Epub 2019 Nov 29.

Service Dermatologie, Centre Hospitalo-Universitaire Joseph Raseta Befelatanana, Antananarivo, Madagascar.

Introduction: Skin cancers are malignant keratinizing tumors of epidermal, melaninic or adnexal origin. These cancers are still little known. However they affect people living in Madagascar where the amount of sunshine remains very high with an impact that varies depending on the skin type. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.167.19269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046123PMC

Adherence to the National Comprehensive Cancer Network Criteria of Complete Circumferential Peripheral and Deep Margin Assessment in Treatment of High-Risk Basal and Squamous Cell Carcinoma.

Dermatol Surg 2020 Mar 6. Epub 2020 Mar 6.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: The National Comprehensive Cancer Network (NCCN) has established guidelines for the treatment of keratinocyte carcinomas (KCs). Complete circumferential peripheral and deep margin assessment (CCPDMA) is recommended for "high-risk" tumors that cannot be closed primarily. If flap or grafts are needed and CCPDMA was not used, it is recommended that reconstruction be delayed until achieving clear margins. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002354DOI Listing