13,652 results match your criteria Pathology - Basal Cell Carcinoma


Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
April 2019
1 Read

Evaluating the trend of cutaneous malignant tumors in Ilam from 2002 to 2011.

J Family Med Prim Care 2019 Feb;8(2):717-721

Department of Cardiology, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: Skin cancer, the melanoma type of which causes high mortality, is the most common malignancy in Iran and all over the world. UV is the most important cause of the incidence of this disease. This study evaluates the frequency of different types of cancer and their trajectory in Ilam province from 2012 to 2011. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jfmpc.jfmpc_178_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436317PMC
February 2019
3 Reads

A Collision Tumor: Reflectance Confocal Microscopy Features and Correlation between Dermoscopy and Histopathology.

Indian J Dermatol 2019 Mar-Apr;64(2):155-157

Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Coexistence of two types of malignant neoplasms, called 'a collision tumor,' is relatively uncommon. Basal cell carcinomas (BCCs) are known to coexist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report a rare case of BCC with underlying lentigo maligna melanoma, focusing on dermoscopic and reflectance confocal microscopic (RCM) findings and their correlation with histopathology. Read More

View Article

Download full-text PDF

Source
http://www.e-ijd.org/text.asp?2019/64/2/155/254153
Publisher Site
http://dx.doi.org/10.4103/ijd.IJD_278_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440176PMC
April 2019
2 Reads

Complete healing of basal cell carcinoma under bendamustine and brentuximab vedotin therapy in a patient with cutaneous lymphoma.

Dermatol Ther 2019 Apr 12:e12934. Epub 2019 Apr 12.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12934DOI Listing
April 2019
1 Read

Upregulation of SNAI2 and SOX9 mRNA versus downregulation of eight other EMT/stemness related genes in Basal Cell Carcinoma.

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Medical Genetics Department, School of Medicine, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, 14176-13151, Iran.

Basal Cell Carcinoma (BCC) is the most common malignancy among fair-skinned people. In contrast to other types of cancer, BCC has the lowest rate of metastasis and mortality. Although several molecular signaling pathways have been documented to play a role in BCC formation, the molecular mechanism to explain why BCC is distinctively rarely metastatic has not been elucidated yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.17995DOI Listing
April 2019
1 Read

Multiple adenoid basal cell carcinoma: An uncommon presentation.

Indian J Dermatol Venereol Leprol 2019 Apr 11. Epub 2019 Apr 11.

Department of Pathology, Cancer Institute, Adyar (W.I.A.), Chennai, Tamil Nadu, India.

Basal cell carcinoma (BCC) is the most common malignant skin tumor which occurs more frequently over the sun exposed parts of body. Its adenoid variant is a rare histological subtype. We report a case of multiple adenoid basal cell carcinomas at unusual sites in a middle-aged male patient. Read More

View Article

Download full-text PDF

Source
http://www.ijdvl.com/preprintarticle.asp?id=255791;type=0
Publisher Site
http://dx.doi.org/10.4103/ijdvl.IJDVL_803_16DOI Listing
April 2019
3 Reads

Ameloblastic carcinoma ex ameloblastoma of the maxilla.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):58-62

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor. Approximately 138 cases were reported. The majority of these cases occurred in the mandible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jomfp.JOMFP_116_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421907PMC
February 2019
1 Read

Breast cancer quantitative proteome and proteogenomic landscape.

Nat Commun 2019 04 8;10(1):1600. Epub 2019 Apr 8.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 21, Solna, Sweden.

In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC subtypes. Additionally, poor-prognosis basal-like and luminal B tumors are further subdivided by immune component infiltration, suggesting the current classification is incomplete. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-09018-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453966PMC
April 2019
2 Reads

Vascular patterns in basal cell carcinoma: Dermoscopic, confocal and histopathological perspectives.

Oncol Lett 2019 May 25;17(5):4112-4125. Epub 2019 Feb 25.

Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.

Basal cell carcinoma (BCC) is the most prevalent skin cancer in the Caucasian population. A variety of different phenotypic presentations of BCC are possible. Although BCCs rarely metastasize, these tumors commonly destroy underlying tissues and should therefore be treated promptly. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/ol.2019.10070
Publisher Site
http://dx.doi.org/10.3892/ol.2019.10070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444327PMC
May 2019
3 Reads

Inflammation: A key process in skin tumorigenesis.

Oncol Lett 2019 May 19;17(5):4068-4084. Epub 2018 Nov 19.

Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, Romania.

The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major scientific interest. While the inflammation induced by environmental agents has well known underlying mechanisms, less is known concerning the oncogenic changes that follow an inflammatory chronic status in the tissue microenvironment that can lead to pro-tumorigenic processes. Regardless of the origin of the environmental factors, the maintenance of an inflammatory microenvironment is a clear condition that favors tumorigenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2018.9735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444305PMC
May 2019
2 Reads

The role of radiotherapy in the management of non-melanoma skin cancer.

Australas J Dermatol 2019 Mar 31. Epub 2019 Mar 31.

Department of Radiation Oncology, Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, New South Wales, Australia.

The global incidence of non-melanoma skin cancer continues to increase as the global population ages with the highest incidence in the world occurring in Australian and New Zealand patients. There are numerous treatment options available for non-melanoma skin cancer patients of which radiotherapy is an efficacious and versatile tissue preserving non-surgical (or medical) option. In patients where excision may not be an option (medically/technically inoperable) or considered less ideal (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.13025DOI Listing
March 2019
2 Reads

Silibinin inhibits ultraviolet B radiation-induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch(+/-) mouse model of basal cell carcinoma.

Mol Carcinog 2019 Mar 25. Epub 2019 Mar 25.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

Around 80% of nonmelanoma skin cancers (NMSCs) are basal cell carcinoma (BCC), still studies evaluating the efficacy of chemopreventive agents during early stage/s of BCC development are lacking. Accordingly, utilizing the well-established patched (Ptch)+/- mouse model of ultraviolet B (UVB) radiation-induced BCC formation, we excised skin samples from UVB exposed Ptch+/- and Ptch+/+ mice before tumor formation to study the promotion/progression of BCC and to determine the efficacy and target/s of silibinin, a well-known skin cancer chemopreventive agent. UVB exposure for 1 month increased the number of mast cells in Ptch+/- mice by ~48% (P < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mc.23008DOI Listing
March 2019
2 Reads

Rare paraneoplastic erythroderma associated with ectopic neuron-specific enolase deposition in basal cells.

Ann Transl Med 2019 Feb;7(3):51

Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China.

The cutaneous symptom of the paraneoplastic erythroderma can be the only symptom of a malignancy. Although many cases associated with malignancies have been reported, the pathogenesis of cancer related erythroderma is still unclear. Herein we presented a patient with large cell neuroendocrine carcinoma (LCNEC) of the lung and contemporary severe erythroderma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2018.12.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389566PMC
February 2019
2 Reads

Cytological features of basal cell adenocarcinoma of the salivary glands.

Diagn Cytopathol 2019 Mar 22. Epub 2019 Mar 22.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Hirakata, Osaka, Japan.

The cytological features of basal cell adenocarcinoma (BAC) of the salivary gland, a rare carcinoma, have not been well described. This study included patients who were histopathologically diagnosed with BAC and who underwent preoperative fine-needle aspiration cytological examination. Cytological characteristics, including background, arrangement and shape of the neoplastic cells, nuclear and cytoplasmic features, and presence of stromal spindle cells, were reviewed. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/dc.24178
Publisher Site
http://dx.doi.org/10.1002/dc.24178DOI Listing
March 2019
11 Reads

Basal Cell Carcinoma Associated with Secondary Localized Cutaneous Amyloid Deposits: Case Report and Review.

Authors:
Philip R Cohen

Cureus 2019 Jan 14;11(1):e3879. Epub 2019 Jan 14.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Amyloid deposition has been observed in tissue specimens of basal cell carcinomas. A 68-year-old man with a nodular basal cell carcinoma on his left arm near the elbow is described; microscopic evaluation of the biopsy tissue specimen shows not only nodular aggregates and strands of atypical basaloid tumor cells but also marked deposition of amorphous amyloid material in the stroma between the aggregates of basal cell carcinoma. Including the man in this report, there are additional individual descriptions of patients whose basal cell carcinomas have amyloid deposits in the adjacent stroma or within the tumor aggregates or both. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420332PMC
January 2019
6 Reads

Skin cancer precursor immunotherapy for squamous cell carcinoma prevention.

JCI Insight 2019 Mar 21;4(6). Epub 2019 Mar 21.

Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown.

Methods: We performed a blinded prospective cohort study on participants of a randomized double-blind clinical trial in which a 4-day course of topical calcipotriol plus 5-FU combination was compared to Vaseline plus 5-FU (control) for AK treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.125476DOI Listing
March 2019
2 Reads

Metatypical Basal Cell Carcinoma: A 6-Year Retrospective Study.

Skinmed 2019 19;17(1):24-28. Epub 2019 Mar 19.

Department of Pathology, Faculty of Medicine of Tunis, University of Tunis El Manar, Med Tahar Maamouri Hospital, Nabeul, Tunisia.

Metatypical basal cell carcinoma (MBCC) represents a high-risk type of cutaneous tumor and has characteristics similar to basal cell carcinoma and squamous cell carcinoma. We report a retrospective study of 13 patients who presented with cervicofacial MBCC. Our study found an increased prevalence of aggressive clinicohistologic features and showed disease recurrences in more than one-third of the patients; therefore, we conclude that MBCC is an aggressive variant that requires a complex surgical approach for achieving a stable and complete remission. Read More

View Article

Download full-text PDF

Source
March 2019
2 Reads

Characterisation of resistance mechanisms developed by basal cell carcinoma cells in response to repeated cycles of Photodynamic Therapy.

Sci Rep 2019 Mar 18;9(1):4835. Epub 2019 Mar 18.

Biology Department, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain.

Photodynamic Therapy (PDT) with methyl-aminolevulinate acid (MAL-PDT) is being used for the treatment of Basal cell carcinoma (BCC), but recurrences have been reported. In this work, we have evaluated resistance mechanisms to MAL-PDT developed by three BCC cell lines (ASZ, BSZ and CSZ), derived from mice on a ptch+/- background and with or without p53 expression, subjected to 10 cycles of PDT (10G). The resistant populations showed mesenchymal-like structure and diminished proliferative capacity and size compared to the parental (P) cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-41313-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423284PMC
March 2019
1 Read

Rapidly progressive miliary brain metastasis of lung cancer after EGFR tyrosine kinase inhibitor discontinuation: An autopsy report.

Neuropathology 2019 Apr 13;39(2):147-155. Epub 2019 Mar 13.

Department of Pathology, Mitsui Memorial Hospital, Tokyo, Japan.

Miliary brain metastasis is a rare type of brain metastasis, in which carcinoma cells disseminate to numerous foci confined to Virchow-Robin/subpial spaces. Symptoms usually progress within several months, and magnetic resonance imaging (MRI) shows multiple small contrast-enhancing lesions. We report an autopsy case of a patient who rapidly deteriorated within a week due to miliary brain metastasis after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) discontinuation, without contrast-enhancing lesions on MRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/neup.12542DOI Listing
April 2019
2 Reads

Nonmelanoma Skin Cancer in Childhood and Young Adult Cancer Survivors Previously Treated With Radiotherapy.

J Natl Compr Canc Netw 2019 Mar;17(3):237-243

dAdult Long-Term Follow-Up Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, and.

Background: Radiotherapy (RT) is a risk factor for nonmelanoma skin cancer (NMSC), specifically basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), but whether features, histology, or recurrence of NMSC after RT resemble those observed in the general population is unknown.

Methods: A retrospective review (1994-2017) was performed within the Adult Long-Term Follow-Up Program and Dermatology Service at Memorial Sloan Kettering Cancer Center. Demographics, clinical features, histology, treatment, and recurrence were collected for this patient cohort that was under close medical surveillance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.6004/jnccn.2018.7096DOI Listing
March 2019
1 Read

Epidemiology of basal and cutaneous squamous cell carcinoma in the United Kingdom 2013-2015: a cohort study.

Br J Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Barts and The London School of Medicine and Dentistry, London, UK.

Background: Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together known as keratinocyte cancers (KCs), are the commonest cancer in Caucasian populations. Recent improvements to registry data collection in England has allowed more accurate analysis of the epidemiology of BCC and cSCC and for the first time we are able to provide an accurate (representative) tumour burden for KC in the UK.

Objective: To estimate the incidence of BCC and cSCC in the UK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.17873DOI Listing
March 2019
1 Read
4.275 Impact Factor

Neurofolicullar hamartoma presenting as a rare adnexal neoplasm in association with basal cell carcinoma.

Caspian J Intern Med 2019 ;10(1):107-110

Department of Pathology, Iran University of Medical Sciences, Tehran, Iran.

Background: Neurofollicular hamartoma (NFH) is characterized histopathologically by fascicles of spindle cells that laterally delimited by hyperplastic folliculosebaceous units. It usually appears on face, near the nose or nasolabial fold. It does not manifest true neural differentiation and recently the term spindle cell predominant trichodiscoma (SCPT) has been used instead. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22088/cjim.10.1.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386336PMC
January 2019
1 Read

'Eternal sunshine of the spotless islands': how dermoscopy may influence confocal microscopy when dealing with squamous cells carcinoma simulating basal cell carcinoma.

J Eur Acad Dermatol Venereol 2019 Mar 9. Epub 2019 Mar 9.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Viale Risorgimento, 80, 42123, Reggio Emilia, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15553DOI Listing
March 2019
1 Read

Uncommon Presentation of Metastatic Squamous Cell Carcinoma of the Skin and Treatment Challenges.

Am J Case Rep 2019 Mar 6;20:294-299. Epub 2019 Mar 6.

Department of Pathology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA.

BACKGROUND Squamous cell carcinoma is one of the most common keratinocytic skin cancers, the other being basal cell carcinoma. It is the second most common skin cancer after melanoma. Cutaneous squamous cell carcinoma is mostly a localized disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.913488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419533PMC
March 2019
4 Reads

Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile.

Case Rep Pathol 2019 27;2019:2301640. Epub 2019 Jan 27.

Department of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, Belgium.

Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity. DIN occurring in the anus is quite rare, and to the best of our knowledge, only one publication reported it. In this report, we describe the clinicopathological features of this entity on anal margin, associated with invasive squamous cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/2301640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369487PMC
January 2019
1 Read

Histopathological changes in the oesophageal mucosa in Egyptian children with corrosive strictures: A single-centre vast experience.

World J Gastroenterol 2019 Feb;25(7):870-879

Department of Paediatrics, Kasr Alainy School of Medicine, Cairo University, Cairo 11562, Egypt.

Background: The caustic ingestion continues to be a major problem worldwide especially in developing countries. The long-term complications include stricture and increased life time risk of oesophageal carcinoma. Patients suffered from corrosive induced oesophageal strictures have more than a 1000-fold risk of developing carcinoma of the oesophagus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v25.i7.870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385009PMC
February 2019
2 Reads

SerpinB2 is involved in cellular response upon UV irradiation.

Sci Rep 2019 Feb 26;9(1):2753. Epub 2019 Feb 26.

Department of Biochemistry and Molecular Biology, University of Szeged, Faculty of Science and Informatics, Szeged, Hungary.

Ultraviolet light induced pyrimidine dimer is a helix distortion DNA damage type, which recruits repair complexes. However, proteins of these complexes that take part in both DNA damage recognition and repair have been well-described, the regulation of the downstream steps of nucleotide excision repair (NER) have not been clearly clarified yet. In a high-throughput screen, we identified SerpinB2 (SPB2) as one of the most dramatically upregulated gene in keratinocytes following UV irradiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-39073-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391458PMC
February 2019
1 Read

Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation.

Nat Cell Biol 2019 03 25;21(3):359-371. Epub 2019 Feb 25.

Department of Pharmacology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Loss of apical-basal polarity and activation of epithelial-mesenchymal transition (EMT) both contribute to carcinoma progression and metastasis. Here, we report that apical-basal polarity inhibits EMT to suppress metastatic dissemination. Using mouse and human epithelial three-dimensional organoid cultures, we show that the PAR-atypical protein kinase C (aPKC) polarity complex inhibits EMT and invasion by promoting degradation of the SNAIL family protein SNAI1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41556-019-0291-8DOI Listing
March 2019
19.679 Impact Factor

Immunoexpression of LGR4 and Β-Catenin in Gastric Cancer and Normal Gastric Mucosa

Asian Pac J Cancer Prev 2019 Feb 26;20(2):519-527. Epub 2019 Feb 26.

Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceará, Brazil. Email:

Background: We evaluated the immunoexpression of LGR4 and β-catenin in primary gastric carcinomas, lymph node metastases and histologically normal gastric mucosa in the surgical margins of gastric primary tumours. Methods: We performed a cross-sectional, observational study, based on 75 gastric carcinoma specimens from gastrectomies conducted at the hospital of the Federal University of Ceará, Brazil. The samples were analysed by tissue microarray and immunohistochemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31557/APJCP.2019.20.2.519DOI Listing
February 2019
6 Reads

Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study.

J Natl Cancer Inst 2019 Feb 25. Epub 2019 Feb 25.

Background: Skin cancer is common after radiotherapy among childhood cancer survivors (CCSs). We studied risks and risk factors for subsequent skin cancers, with emphasis on radiation dose, exposed skin surface area, and chemotherapeutic agents.

Methods: The DCOG-LATER cohort study includes 5-year Dutch CCSs diagnosed 1963-2001. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djy212DOI Listing
February 2019
1 Read

SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma.

Breast Cancer Res Treat 2019 Feb 23. Epub 2019 Feb 23.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.

Purpose: Invasive lobular carcinoma (ILC) is a histological subtype of breast cancer that is predominantly estrogen receptor alpha (ER)-positive (+) and is thus treated with endocrine therapies. Herein, we sought to understand the molecular underpinnings of the 4-hydroxytamoxifen (4OHT) resistance in ILC by assessing the potential role of the epithelial-to-mesenchymal transition transcription factor (EMT-TF) SNAIL (SNAI1).

Methods: Using a series of breast cancer cell lines, we measured the basal, estrogen and 4OHT-induced expression of SNAIL and other EMT-TF family members by quantitative reverse transcription-polymerase chain reaction and immunoblotting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-019-05161-8DOI Listing
February 2019
1 Read

High-risk basal cell carcinoma excision in primary care: a retrospective observational study of compliance with NICE guidance.

BMJ Open 2019 Feb 22;8(11):e023299. Epub 2019 Feb 22.

Plastic Surgery Department, Salisbury District Hospital, Salisbury, UK.

Objectives: To assess compliance with 2010 National Institute for Health and Care Excellence (NICE) guidance on cancer services relating to the management of basal cell carcinomas (BCC) in the community, where except in specific circumstances it is recommended that only low-risk BCCs should be excised routinely.

Design And Setting: A retrospective observational study of the histopathology reports of BCC excisions received from primary care in two district general hospitals in the South of England. One hundred consecutive BCC excisions were analysed from each hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278784PMC
February 2019
2 Reads

Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary-care centre.

Singapore Med J 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore.

We retrospectively reviewed the clinical features, management and outcomes of patients diagnosed with basal cell carcinoma (BCC) of the vulva at the Gynaecological Cancer Centre, KK Women's and Children's Hospital, Singapore, between 1 January 2000 and 28 February 2014. Patients with vulvar BCC were identified from the cancer registry, and their medical records reviewed and analysed. A total of 11 patients with vulvar BCC were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11622/smedj.2019014DOI Listing
February 2019
2 Reads

S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 2: Treatment, Prevention and Follow-up.

J Dtsch Dermatol Ges 2019 Feb;17(2):214-230

Department of Dermatology, Mainz University Medical Center, Mainz, Germany.

Basal cell carcinoma (BCC) is the most common malignant tumor among fair-skinned individuals, and its incidence had been steadily rising in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 2 addresses issues such as proper risk stratification, the various therapeutic approaches, and prevention as well as follow-up of patients with basal cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ddg.13755
Publisher Site
http://dx.doi.org/10.1111/ddg.13755DOI Listing
February 2019
7 Reads

Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas.

Curr Health Sci J 2018 Apr-Jun;44(2):166-171. Epub 2018 Mar 27.

Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, Romania.

Basal cell carcinomas (BCCs) are malignant tumors with particular biological prognosis and behavior, and the biomolecular investigation of these lesions can provide important therapeutic targets for epithelial neoplasia. In this study we analyzed the immunoexpression of transforming growth factor beta 3 (TGFβ3) and its receptor type III (TGFβRIII) for 53 cases of BCC in relation to the main histopathological prognostic parameters. The results indicated statistically significant differences of TGFβ3 and TGFβRIII expression related to histological type and lesion stage, the both proteins being higher expressed in adenoid and morpheaform advanced stage tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12865/CHSJ.44.02.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320465PMC

Effects of new tetrahydroquinoline-isoxazole hybrids on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria.

Chem Biol Interact 2019 Apr 6;302:164-171. Epub 2019 Feb 6.

Grupo de Investigación en Bioquímica y Microbiología GIBIM, Escuela de Química, Universidad Industrial de Santander, A.A. 678, Bucaramanga, Colombia; Grupo de Investigación en Compuestos Orgánicos de Interés Medicinal CODEIM, Parque Tecnológico Guatiguará, Universidad Industrial de Santander, A. A. 678, Piedecuesta, Colombia. Electronic address:

New molecular hybrids were synthesized by combining tetrahydroquinoline (THQ) and isoxazole (ISX) scaffolds, in search for chemical structures with improved pharmacological properties. Our tetrahydroquinoline (THQ) and isoxazole (ISX) hybrids differ in the X and Y substituents: FM53 (X = H; Y= H), FM49 (X = CH; Y= OCH), FM50 (X = Cl; Y= H) and FM48 (X = Cl; Y= OCH). Aiming at exploring their bioactivity in liver cancer cells, in this paper we report the effect of four THQ-ISX hybrids on viability, respiration and oxidative stress in Hep-G2 human hepatoma cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2019.02.002DOI Listing
April 2019
2 Reads

Long-term recurrence rates of whole specimen intraoperative frozen section analysis in basal cell carcinomas of the face with WIFSA.

J Surg Oncol 2019 Feb 8. Epub 2019 Feb 8.

Department of Plastic Surgery and Hand Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.

Background And Objectives: Recent studies show that whole specimen intraoperative frozen section analysis (WIFSA) is a reliable method for margin analysis in basal cell carcinoma (BCC) and has low recurrence rates after five-years follow-up. There are no studies with longer follow-up. Our aim is to present long-term recurrence rates after WIFSA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25396DOI Listing
February 2019
1 Read

More than meets the eye.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Otolaryngology Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.

We report an extremely rare case of a hybrid tumour of the maxillary sinus. A 51-year-old man presented with a 6-week history of nasal congestion and epiphora. Radiological imaging demonstrated a maxillary sinus tumour, with extensive local invasion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2015-212000DOI Listing
February 2019
4 Reads

Recent Advances in Pathology: the 2019 Annual Review Issue of The Journal of Pathology.

J Pathol 2019 Apr;247(5):535-538

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields and our intention is to provide comprehensive updates in specific areas of pathology in which there has been considerable recent progress. Copyright © 2019 Pathological Society of Great Britain and Ireland. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/path.5255
Publisher Site
http://dx.doi.org/10.1002/path.5255DOI Listing
April 2019
15 Reads

Patterns of proliferation and apoptosis in different subtypes of basal cell carcinoma, adjacent epidermis, and recurrent forms.

An Bras Dermatol 2019 Jan-Feb;94(1):108-110

Dermatology Course, Department of Dermatology and Radiotherapy, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu (SP), Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/abd1806-4841.20198165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360986PMC
March 2019
2 Reads

Study of skin neoplasms in a university hospital: integration of anatomopathological records and its interface with the literature.

An Bras Dermatol 2019 Jan-Feb;94(1):42-46

Service of Dermatology, Hospital Escola Álvaro Alvim, Campos dos Goytacazes (RJ), Brazil.

Background: Skin cancer is a highly prevalent condition with a multifactorial etiology resulting from genetic alterations, environmental and lifestyle factors. In Brazil, among all malignant tumors, skin cancers have the highest incidences.

Objective: To retrospectively evaluate the incidence, prevalence and profile of basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma in Campos dos Goytacazes and region. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/abd1806-4841.20197357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360975PMC
February 2019
2 Reads

Peritumoural clefting as a key feature in differentiating basal cell carcinoma from trichoblastoma through in vivo reflectance confocal microscopy.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15467DOI Listing
February 2019
10 Reads

Basal Cell Carcinoma Pathology Requests and Reports Are Lacking Important Information.

J Skin Cancer 2019 3;2019:4876309. Epub 2019 Jan 3.

Department of Dermatology, Jordan University of Science and Technology, P.O. Box 3030, Irbid, Jordan.

Introduction: Basal cell carcinoma (BCC) is the most common cancer affecting humans. Luckily it has negligible risk for metastasis; however it can be locally destructive to surrounding tissue. The diagnosis of this tumor relies on clinical and dermoscopic features; however confirmation requires biopsy and histologic examination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/4876309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335659PMC
January 2019
6 Reads

Extremity nevus count is an independent risk factor for basal cell carcinoma and melanoma, but not squamous cell carcinoma.

J Am Acad Dermatol 2019 Apr 31;80(4):970-978. Epub 2019 Jan 31.

Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana. Electronic address:

Background: The presence of nevi portends an increased risk for melanoma.

Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers.

Methods: We evaluated prospective cohorts of 176,317 women (the Nurses' Health Study, 1986-2012 and the Nurses' Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01909622183265
Publisher Site
http://dx.doi.org/10.1016/j.jaad.2018.09.044DOI Listing
April 2019
11 Reads

Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma.

J Invest Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London, UK. Electronic address:

Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the United Kingdom. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-κB signaling pathways and has been documented as highly expressed in several types of human cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.01.020DOI Listing
January 2019
2 Reads

Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma.

J Invest Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA. Electronic address:

Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naive tumor responsiveness to Smoothened inhibitors (Smo), resistance in advanced tumors remains common. Although the resistant BCCs usually maintain HH pathway activation, squamous cell carcinomas with Ras/MAPK pathway activation also arise, and the molecular basis of tumor type and pathway selection are still obscure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2018.11.035DOI Listing
January 2019
3 Reads

[Clinicopathological analysis of cervical basaloid squamous cell carcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):7-12

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.003DOI Listing
January 2019
13 Reads

Isolation, Characterization and Proliferation of Cancer Cells from Breast Cancer Patients.

Acta Inform Med 2018 Dec;26(4):240-244

Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.

Introduction: The most cases of cancer death, which are in the first rank among cancers suffered by women is breast cancer. The breast cancer therapy for patients has been done, but still not optimal, so it is necessary to understand the mechanism of therapy in model cell of breast cancer.

Aim: This study aim to develop an isolation technique of breast cancer cell from patients as a cancer cell model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5455/aim.2018.26.240-244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311122PMC
December 2018
4 Reads

Effect of Sentinel Node Biopsy in Clinically N0, BRAF V600E-Mutated, Small Papillary Thyroid Carcinoma: A Pilot Study.

Clin Nucl Med 2019 May;44(5):359-364

General Surgery Unit, Azienda Ospedaliera Universitaria Pisana.

Purpose: BRAF V600E mutation papillary thyroid cancer (PTC) is more aggressive with a higher risk of lymph node involvement and a poorer prognosis. Prior studies failed to demonstrate the superiority of prophylactic lymphadenectomy. We investigated the utility of additional radio-guided sentinel node biopsy (SNB). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002465DOI Listing
May 2019
4 Reads