14,861 results match your criteria Pathology - Basal Cell Carcinoma


Dermoscopic features of basal cell carcinoma in skin of color: A retrospective cross-sectional study from Puducherry, South India.

Indian J Dermatol Venereol Leprol 2021 Apr 23:1-7. Epub 2021 Apr 23.

Department of Pathology, AIIMS, Bhubaneswar, Odisha, India.

Background: Dermoscopy is useful in the diagnosis of basal cell carcinoma (BCC). However, most descriptions of the dermoscopic features of BCCs are in Caucasians (skin types I-III) and there is a paucity of data in dark-skinned Indian patients.

Aims: The aim of this study was to describe the various dermoscopic features of BCC in dark-skinned patients from South India and correlate these with the histopathologic subtypes. Read More

View Article and Full-Text PDF

p53 Expression, Programmed Death Ligand 1, and Risk Factors in Urinary Tract Small Cell Carcinoma.

Front Oncol 2021 22;11:651754. Epub 2021 Apr 22.

Department of Pathology and Laboratory Medicine, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, United States.

Small cell carcinoma of the urinary tract (SCCUT) is a rare finding with poor clinical course. This study sheds light on the molecular subtype and identifies risk factors in patients diagnosed with SCCUT. Immunohistochemical expression of immunotherapy target programmed death ligand 1 (PD-L1) and luminal (GATA3), basal (p63), and p53 markers are assessed in patients diagnosed with SCCUT. Read More

View Article and Full-Text PDF

Gorlin syndrome: A rare case report.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):591. Epub 2021 Jan 9.

Department of Oral Surgery, Government Dental College, Raipur, Chhattisgarh, India.

Gorlin syndrome is an autosomal dominant inherited condition that exhibits high penetrance and variable expressivity. The syndrome is caused by mutations in PTCH, a tumor suppressor gene that has been mapped to chromosome 9q22.3-q31. Read More

View Article and Full-Text PDF
January 2021

Morphometric analysis of basal cells of oral epithelium in predicting malignant transformation of oral potentially malignant disorders in patients with tobacco chewing habit.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):579. Epub 2021 Jan 9.

Department of Oral and Maxillofacial Pathology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.

Background: Oral potentially malignant disorders (OPMDs) are a heterogenous group of disorders which precede the development of oral cancer. These are characterized by increased risk of malignant transformation to Oral cancer.

Aims & Objectives: In this study, an attempt has been made to assess the morphological alterations of the nuclei of the basal cells in OPMDs and oral squamous cell carcinoma (OSCC). Read More

View Article and Full-Text PDF
January 2021

Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component.

Vet Comp Oncol 2021 May 7. Epub 2021 May 7.

University of Nottingham, BioDiscovery Institute, Nottingham, UK.

A limited number of species, including men and dogs, spontaneously develop prostate cancer (PC). The histological and molecular relevance of canine PC as a model for the disease in men remains controversial. To address this challenge, this study aimed to assess the histomorphology and expression of basal cell, urothelial and neuroendocrine markers [p63, high molecular weight cytokeratin (HMWCK), Uroplakin 3 (UPIII), neuron-specific enolase (NSE)] in canine PC (n=41). Read More

View Article and Full-Text PDF

Basal Cell Carcinoma Arising from an Epidermoid Cyst: A Histopathological Surprise.

Indian Dermatol Online J 2021 Mar-Apr;12(2):351-352. Epub 2020 Sep 28.

Pathology Consultancy Services, B-6, Sector 27, Noida, Uttar Pradesh, India.

View Article and Full-Text PDF
September 2020

Domain adaptation and self-supervised learning for surgical margin detection.

Int J Comput Assist Radiol Surg 2021 May 6. Epub 2021 May 6.

School of Computing, Queen's University, Ontario, Canada.

Purpose: One in five women who undergo breast conserving surgery will need a second revision surgery due to remaining tumor. The iKnife is a mass spectrometry modality that produces real-time margin information based on the metabolite signatures in surgical smoke. Using this modality and real-time tissue classification, surgeons could remove all cancerous tissue during the initial surgery, improving many facets of patient outcomes. Read More

View Article and Full-Text PDF

Keratinocyte Skin Cancers in General Surgery: The Impact of Anaesthesia, Trainee Supervision, and Choice of Reconstruction.

J Skin Cancer 2021 13;2021:5537273. Epub 2021 Apr 13.

Caboolture Hospital, 120 McKean Street, Caboolture 4310, QLD, Australia.

Background: Keratinocyte skin cancers are common in Australia, incurring disproportionately high health expenditure in comparison with mortality. General surgeons often excise these lesions as day-surgery. Balancing individual complexities of these cancers with trainee supervision and health expenditure is key to deliver efficacious care and maintain day-surgery volume for patients during a pandemic. Read More

View Article and Full-Text PDF

Differential Diagnosis and Management on Seborrheic Keratosis in Elderly Patients.

Clin Cosmet Investig Dermatol 2021 28;14:395-406. Epub 2021 Apr 28.

Dermatology Unit, University of Campania, Naples, Italy.

Seborrheic keratoses are exceedingly common in the elderly and usually are easy to diagnose and do not require treatment. However, given their great variety of clinical presentation, they may give rise to false-positive cases, meaning that they may at times mimic melanoma, squamous cell carcinoma and basal cell carcinoma. On the other hand, melanoma may mimic seborrheic keratosis, leading to incorrect patient management. Read More

View Article and Full-Text PDF

Interdigitating Dendritic Cell Tumor of Submandibular Lymph Node: Case Report and Literature Review.

Iran J Pathol 2021 21;16(2):237-242. Epub 2020 Dec 21.

Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Dendritic cells (DCs) are key arms of immune system, which act in antigen presenting processes, and are considered as a bridge between innate and adaptive immune responses. DCs are found in both lymphoid and non-lymphoid organs. They are called interdigitating dendritic cells (IDCs) in secondary lymphoid organs. Read More

View Article and Full-Text PDF
December 2020

Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.

J Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Primary cilia (PC) are non-motile, antenna-like structures on the cell surface. Many types of neoplasms exhibit PC loss, whereas in some neoplasms PC are retained and involved in tumourigenesis. To elucidate the PC status and characteristics of major salivary gland tumours (SGTs), we examined 100 major SGTs encompassing eight histopathological types by immunohistochemical analysis. Read More

View Article and Full-Text PDF

Noninvasive papillary urothelial carcinoma with pathological features in between low and high grades: A case report.

Medicine (Baltimore) 2021 Apr;100(17):e25693

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.

Rationale: Urinary bladder urothelial carcinoma is the most common malignant tumor in the urinary system, and noninvasive papillary urothelial carcinoma (NIPUC) comprises most bladder malignancies. NIPUC grading is important for therapeutic and clinical protocol selection. Here, we report a case of NIPUC with pathological features in between low (LG-NIPUC) and high (HG-NIPUC) grades NIPUC. Read More

View Article and Full-Text PDF

Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer.

Malays J Pathol 2021 Apr;43(1):49-54

Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Pathology, 43400 UPM Serdang, Selangor, Malaysia.

Introduction: Hedgehog (HH) pathway is an important signalling cascade for growth and patterning during embryonic development. Constitutive activation of Hedgehog pathway can be found in various types of malignancies including medulloblastoma, basal cell carcinoma, gastrointestinal, breast, pancreatic, prostate cancer and leukaemia. Little is known about the expression and role of Hedgehog signalling in bladder cancer. Read More

View Article and Full-Text PDF

Aberrant epithelial polarity cues drive the development of precancerous airway lesions.

Proc Natl Acad Sci U S A 2021 May;118(18)

Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118;

Molecular events that drive the development of precancerous lesions in the bronchial epithelium, which are precursors of lung squamous cell carcinoma (LUSC), are poorly understood. We demonstrate that disruption of epithelial cellular polarity, via the conditional deletion of the apical determinant Crumbs3 (Crb3), initiates and sustains precancerous airway pathology. The loss of Crb3 in adult luminal airway epithelium promotes the uncontrolled activation of the transcriptional regulators YAP and TAZ, which stimulate intrinsic signals that promote epithelial cell plasticity and paracrine signals that induce basal-like cell growth. Read More

View Article and Full-Text PDF

Combination of targeted therapy and immune checkpoint blocker in a patient with xeroderma pigmentosum presenting an aggressive angiosarcoma and a recurrent non-resectable basal cell carcinoma.

Eur J Cancer 2021 Apr 23;150:130-132. Epub 2021 Apr 23.

Dermatology Unit, Gustave Roussy Cancer Campus, Villejuif, France; Inserm U981, Gustave Roussy Cancer Campus, Villejuif, France; University Paris-Saclay, Faculty of Medicine, Kremlin-Bicêtre, France. Electronic address:

View Article and Full-Text PDF

Pan-TRK Immunohistochemistry Is Highly Correlated With NTRK3 Gene Rearrangements in Salivary Gland Tumors.

Am J Surg Pathol 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Centre Henri Becquerel INSERM 1245, Rouen Normandy Uniiversity Department of Pathology, Rouen University Hospital, Rouen Platform of Experimental Pathology, Department of Diagnostic and Theranostic Medicine, Curie Institute Department of Pathology, Lariboisière Hospital, Paris, France.

Aims: Secretory carcinoma (SC) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors (SGTs), SCs can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK (tropomyosin receptor kinase) antibody shows promise for identifying tumors with NTRK (neurotrophic tyrosine kinase receptor 3) fusions. Read More

View Article and Full-Text PDF

Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons.

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

UCSF Dermatopathology and Oral Pathology Service, University of California San Francisco, San Francisco, CA; Departments of Pathology and Dermatology, University of California San Francisco, San Francisco, CA; Department of Dermatology, Yale University School of Medicine, New Haven, CT; and Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, CA.

Abstract: Pseudocarcinomatous desmoplastic trichoepithelioma (PDTE) features verrucous squamous epidermal hyperplasia with a jagged undersurface overlying cords of follicular germinative cells in a fibrotic stroma. To date, only 5 cases have been reported. We identified 7 new PDTEs from 2 institutions and reviewed their clinical manifestations and immunohistochemical profile. Read More

View Article and Full-Text PDF

Expression of Transient Receptor Potential Channel of Melastatin number 8 (TRPM8) in Non- Melanoma Skin Cancer: A Clinical and Immunohistochemical study.

J Immunoassay Immunochem 2021 Apr 25:1-13. Epub 2021 Apr 25.

Dermatology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.

Transient Receptor Potential Channel of Melastatin number 8 (TRPM8) is abnormally expressed in many cancers as lung, however little is known about TRPM8 expression in non-melanoma skin cancer (NMSC) including cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). This work aimed to study TRPM8 expression in NMSC. It included 100 skin biopsies (50 normal skin as control group, 15 BCC and 35 SCC). Read More

View Article and Full-Text PDF

Interplay of autophagy and cancer stem cells in hepatocellular carcinoma.

Mol Biol Rep 2021 Apr 24. Epub 2021 Apr 24.

Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, 47500 Subang Jaya, Bandar Sunway, Selangor Darul Ehsan, Malaysia.

Liver cancer is the sixth most common cancer and the fourth leading cause of cancer deaths in the world. The most common type of liver cancers is hepatocellular carcinoma (HCC). Autophagy is the cellular digestion of harmful components by sequestering the waste products into autophagosomes followed by lysosomal degradation for the maintenance of cellular homeostasis. Read More

View Article and Full-Text PDF

Basal cell carcinoma with signet ring cell morphology accumulating the ubiquitinated cytokeratin 5/6.

BMJ Case Rep 2021 Apr 23;14(4). Epub 2021 Apr 23.

Department of Pathology, Japanese Red Cross Akita Hospital, Akita, Japan.

Basal cell carcinoma (BCC) showing signet ring (SR) cell morphology is a very rare variant of BCC. Here, we report BCC with SR cell morphology developed in the right cheek skin of a 79-year-old man. Histopathologic examination showed irregularly shaped islands of basaloid cells with characteristic peripheral palisading. Read More

View Article and Full-Text PDF

Basal Cell Nevus Syndrome with Unusual Associated Findings: A Case Report with 17 Years of Follow-Up.

Am J Case Rep 2021 Apr 22;22:e928670. Epub 2021 Apr 22.

School of Dentistry, Federal University of Pará (UFPA), Belém, PA, Brazil.

BACKGROUND Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin-Goltz syndrome (GGS), is an inherited autosomal dominant disorder caused by mutations in the patched (PTCH) tumor-suppressor gene, which has high penetrance and variable phenotypic expressivity. In 1960, Gorlin and Goltz defined the condition by 3 main characteristics: multiple basal cell carcinomas, odontogenic keratocyst (OKC), and skeletal anomalies. Nowadays, many neurologic, ophthalmic, endocrine, and genital manifestations are known to be associated with this syndrome. Read More

View Article and Full-Text PDF

Expression Analysis of Same-Patient Metachronous and Synchronous Upper-Tract and Bladder Urothelial Carcinoma.

J Urol 2021 Apr 21:101097JU0000000000001788. Epub 2021 Apr 21.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: To compare upper-tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BUC) in same-patient metachronous-(m) and synchronous-(s) UTUC and BUC using next generation sequencing.

Materials And Methods: Consecutive untreated same-patient samples of UTUC and BUC were macrodissected from unstained formalin-fixed, paraffin-embedded slides after quality control. Samples were divided into 4 groups: 1) UTUC-mBUC, 2) BUC-mUTUC, 3) sUTUC-BUC, 4) UTUC without BUC. Read More

View Article and Full-Text PDF

[Teledermatology in the Health Center West Area of Granada: From primary to specialized care].

Semergen 2021 Apr 13. Epub 2021 Apr 13.

Servicio de Dermatología, Hospital Universitario San Cecilio, Granada, España; Instituto biosanitario de Granada, Ibs, Granada, Spain. Electronic address:

Introduction: Teledermatology (TD) is a health tool based on the application of information and communication technologies (ICT) for the care of skin diseases at a distance, allowing a better connection between primary care professionals (PCP) and specialized care. The objective of this study was to analyze the characteristics of the teleconsultations made to our service in a period of 2years (January 1, 2018 to December 31, 2019).

Material And Methods: The data was obtained from a TD system with dermoscopy that allows teleconsultations to be carried out asynchronously. Read More

View Article and Full-Text PDF

Current and future perspectives of digital microscopy with fluorescence confocal microscope for prostate tissue interpretation: a narrative review.

Transl Androl Urol 2021 Mar;10(3):1569-1580

Department of Urology, University of Modena and Reggio Emilia, Modena, Italy.

Fluorescence confocal microscopy (FCM) is an optical imaging technique providing digital microscopical images of fresh tissue in a real time fashion, without conventional processing. FCM has been widely applied in several fields of dermatology, including the detection of basal cell carcinoma and of cutaneous inflammatory diseases. The aim of the paper is to provide an overview of FCM applications in the field of prostate tissue interpretation and prostate cancer (PCa) detection. Read More

View Article and Full-Text PDF

Cytological Evaluation of Palpebral Lesions: An Insight into its Limitations Aided with Histopathological Corroboration.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):12-17. Epub 2020 Nov 9.

Department of Pathology, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.

Context: Eyelids by virtue of its unique histomorphology give rise to multitudes of different pathological conditions. Appropriate preoperative cytological diagnoses of these cases are necessary to determine their optimal therapy.

Aims: The aims of this study were to evaluate the utility of various cytological techniques in diagnosing the definite pathology for palpebral lesions and thereby to highlight the drawbacks associated with cytology in this context. Read More

View Article and Full-Text PDF
November 2020

Tissue Expression of Carbonic Anhydrase IX Correlates to More Aggressive Phenotype of Basal Cell Carcinoma.

Front Oncol 2021 25;11:659332. Epub 2021 Mar 25.

Pathology Unit, Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy.

Basal cell carcinoma (BCC) is the most common cancer in the white-skinned population accounting for about 15% of all neoplasms. Its incidence is increasing worldwide, at a rate of about 10% per year. BCC, although infrequently metastasizing, very often causes extensive tissue losses, due to the high propensity toward stromal infiltration, particularly in its dedifferentiated forms, with disfiguring and debilitating results. Read More

View Article and Full-Text PDF

Nuclear factor IB is downregulated in vulvar squamous cell carcinoma (VSCC): Unravelling differentially expressed genes in VSCC through gene expression dataset analysis.

Oncol Lett 2021 May 16;21(5):381. Epub 2021 Mar 16.

Department of Pathology, Erasmus MC, University Medical Center Rotterdam, 3000CA Rotterdam, The Netherlands.

Vulvar squamous cell carcinoma (VSCC) comprises two distinct etiopathological subtypes: i) Human papilloma virus (HPV)-related VSCC, which arises via the precursor high grade squamous intraepithelial lesion (HSIL); and ii) HPV-independent VSCC, which arises via precursor, differentiated vulvar intraepithelial neoplasia (dVIN), driven by mutations. However, the mechanism of carcinogenesis of VSCC is poorly understood. The current study aimed to gain insight into VSCC carcinogenesis by identifying differentially expressed genes (DEGs) for each VSCC subtype. Read More

View Article and Full-Text PDF

The Triangular Dart Flap: A Reconstructive Option for Soft Tissue Defects.

Ann Plast Surg 2021 Apr 5. Epub 2021 Apr 5.

From the Department of Plastic and Reconstructive Surgery, Wake Forest School of Medicine; Winston-Salem, NC.

Introduction: Reconstruction of soft tissue defects after skin cancer excision remains a challenge. Options for reconstruction are numerous, including primary repair, local tissue rearrangement, and skin grafts, among others. In this series, the authors present a novel technique: The triangular dart flap. Read More

View Article and Full-Text PDF

[Application of immunohistochemical staining of bcl-2, Ber-EP4, CD10, CK20, and Ki-67 in differential diagnosis between trichoblastoma and basal cell carcinoma].

Zhonghua Bing Li Xue Za Zhi 2021 Apr;50(4):376-381

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

To study the utility of immunohistochemistry (IHC) in differential diagnosis between trichoblastoma (TB) and basal cell carcinoma (BCC). Fifty-eight cases of TB and 40 cases of BCC were collected at Fudan University Shanghai Cancer Center from January 2009 to December 2019 and retrospectively analyzed by IHC for bcl-2, Ber-EP4, CD10, CK20 and Ki-67. Fisher exact test was performed for statistical analysis. Read More

View Article and Full-Text PDF

Carcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic Considerations.

Adv Anat Pathol 2021 May;28(3):150-170

Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.

Most cervical carcinomas and their related lesions are attributed to an infection by human papillomavirus (HPV). The infection usually starts in the basal cells at the squamocolumnar junction. It causes cell proliferation and maturation abnormalities along with nuclear abnormalities resulting in low-grade squamous intraepithelial lesions. Read More

View Article and Full-Text PDF