6,337 results match your criteria Pathology[Journal]


REMOVED: Fatal penetrating injury to the neck due to defective airbag deployment.

Pathology 2018 Feb 17;50 Suppl 1:S96-S97. Epub 2019 Jan 17.

Department of Forensic Medicine, Glebe, Forensic and Analytic Science Service, NSW Health Pathology, Australia.

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http://dx.doi.org/10.1016/j.pathol.2017.12.268DOI Listing
February 2018

Laboratory testing for lupus anticoagulant (LA) in patients taking direct oral anticoagulants (DOACs): potential for false positives and false negatives.

Pathology 2019 Jan 18. Epub 2019 Jan 18.

Department of Laboratory Haematology, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia; Sydney Centres for Thrombosis and Haemostasis, Sydney, NSW, Australia.

We and others have previously highlighted the potential problems with testing of lupus anticoagulants (LA) in patients on anticoagulant therapy, including most recently as related to the direct oral anticoagulants (DOACs). Thus, current DOACs in use (e.g. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.008DOI Listing
January 2019
1 Read

HDL and cardiovascular disease.

Pathology 2019 Feb 3;51(2):142-147. Epub 2019 Jan 3.

South Australian Health and Medical Research Institute, Adelaide, SA, Australia.

High-density lipoprotein (HDL) has received increasing interest due to observations of an inverse relationship between its systemic levels and cardiovascular risk and targeted interventions in animal models that have had favourable effects on atherosclerotic plaque. In addition to its pivotal role in reverse cholesterol transport, HDL has been reported to possess a range of functional properties, which may exert a protective influence on inflammation, oxidation, angiogenesis and glucose homeostasis. This has led to the development of a range of HDL targeted therapeutics, which have undergone evaluation in clinical trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183051
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http://dx.doi.org/10.1016/j.pathol.2018.10.017DOI Listing
February 2019
5 Reads

Apheresis for severe hypercholesterolaemia and elevated lipoprotein(a).

Pathology 2019 Feb 2;51(2):227-232. Epub 2019 Jan 2.

Medical Department IV - Grosshadern, University Munich, Munich, Germany.

Low-density lipoprotein (LDL)-cholesterol (LDL-c) and lipoprotein(a) [Lp(a)] are independent cardiovascular risk factors. Reduction of LDL-c leads to reduction in cardiovascular events, regardless of the method of reducing LDL-c levels. Lifestyle modification and drugs are first line treatment options. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183039
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http://dx.doi.org/10.1016/j.pathol.2018.10.016DOI Listing
February 2019
1 Read

Calreticulin mutation specific CAL2 immunohistochemistry accurately identifies rare calreticulin mutations in myeloproliferative neoplasms.

Pathology 2018 Dec 31. Epub 2018 Dec 31.

MTA-SE Momentum Molecular Oncohematology Research Group, Semmelweis University, 1st Department of Pathology and Experimental Cancer Research, Budapest, Hungary. Electronic address:

Mutations of the multifunctional protein calreticulin (CALR) are recognised as one of the main driver alterations involved in the pathogenesis of Philadelphia negative myeloproliferative neoplasms (Ph MPN) and also represent a major diagnostic criterion in the most recent World Health Organization classification of myeloid neoplasms. Nowadays, quantitative assessment of the driver mutations is gaining importance, as recent studies demonstrated the clinical relevance of the mutation load reflecting the size of the mutant clone. Here, we performed for the first time a manual and automated quantitative assessment of the CALR mutation load at protein level using CAL2, a recently developed CALR mutation specific monoclonal antibody, on a cohort of 117 patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF) and compared the CALR protein mutation loads with the CALR mutation load values established by a molecular assay. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183038
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http://dx.doi.org/10.1016/j.pathol.2018.11.007DOI Listing
December 2018
3 Reads

Update on the diagnosis, treatment and management of rare genetic lipid disorders.

Pathology 2019 Feb 28;51(2):193-201. Epub 2018 Dec 28.

School of Medicine, Faculty of Health & Medical Sciences, University of Western Australia, Perth, WA, Australia; Department of Clinical Biochemistry, PathWest Laboratory Medicine WA, Royal Perth Hospital & Fiona Stanley Hospital Network, Perth, WA, Australia. Electronic address:

Rare genetic lipid disorders affect the levels of cholesterol and/or triglyceride in the circulation and, if untreated, can often lead to severe multisystem complications. The field of rare lipid disorders is evolving and increasing awareness of these conditions, along with the systematic integration of recent advances or knowledge into clinical practice, is crucial to improve patient outcomes. The aim of this review is to provide an overview of selected rare genetic lipid disorders, focusing on the recommended diagnostic strategies and contemporary treatment and management options. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.005DOI Listing
February 2019
2.188 Impact Factor

Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease.

Authors:
A David Marais

Pathology 2019 Feb 28;51(2):165-176. Epub 2018 Dec 28.

Chemical Pathology Division, Pathology Department, University of Cape Town Health Science Faculty and National Health Laboratory Service, Cape Town, South Africa. Electronic address:

Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids, predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to mediate the clearance of their remnants after enzymatic lipolysis in the circulation. Its synthesis in macrophages initiates the formation of high density-like lipoproteins to effect reverse cholesterol transport to the liver. In the nervous system apoE forms similar lipoproteins which perform the function of distributing lipids amongst cells. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.002DOI Listing
February 2019

Lipodystrophies, dyslipidaemias and atherosclerotic cardiovascular disease.

Pathology 2019 Feb 27;51(2):202-212. Epub 2018 Dec 27.

Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Lipodystrophies are rare, heterogeneous, genetic or acquired, disorders characterised by varying degrees of body fat loss and associated metabolic complications, including insulin resistance, dyslipidaemias, hepatic steatosis and predisposition to atherosclerotic cardiovascular disease (ASCVD). The four main types of lipodystrophy, excluding antiretroviral therapy-induced lipodystrophy in HIV-infected patients, are congenital generalised lipodystrophy (CGL), familial partial lipodystrophy (FPLD), acquired generalised lipodystrophy (AGL) and acquired partial lipodystrophy (APL). This paper reviews the literature related to the prevalence of dyslipidaemias and ASCVD in patients with lipodystrophies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183052
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http://dx.doi.org/10.1016/j.pathol.2018.11.004DOI Listing
February 2019
5 Reads

Lipoprotein(a) catabolism: a case of multiple receptors.

Pathology 2019 Feb 27;51(2):155-164. Epub 2018 Dec 27.

Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria.

Lipoprotein(a) [Lp(a)] is an apolipoprotein B (apoB)-containing plasma lipoprotein similar in structure to low-density lipoprotein (LDL). Lp(a) is more complex than LDL due to the presence of apolipoprotein(a) [apo(a)], a large glycoprotein sharing extensive homology with plasminogen, which confers some unique properties onto Lp(a) particles. ApoB and apo(a) are essential for the assembly and catabolism of Lp(a); however, other proteins associated with the particle may modify its metabolism. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.003DOI Listing
February 2019

Non-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment.

Pathology 2019 Feb 27;51(2):148-154. Epub 2018 Dec 27.

School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia; Department of Clinical Biochemistry, Royal Perth Hospital and Fiona Stanley Hospital Network, PathWest Laboratory Medicine, Perth, WA, Australia. Electronic address:

Low density lipoprotein (LDL) is the predominant atherogenic lipoprotein particle in the circulation. Conventionally, a fasting lipid profile has been used for atherosclerotic cardiovascular disease (ASCVD) risk assessment. A non-fasting sample is now regarded as a suitable alternative to a fasting sample. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183059
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http://dx.doi.org/10.1016/j.pathol.2018.11.006DOI Listing
February 2019
4 Reads
2.188 Impact Factor

Lipids and cardiovascular disease.

Pathology 2019 Feb 27;51(2):129-130. Epub 2018 Dec 27.

Departments of Medicine and Biochemistry, Schulich School of Medicine and Robarts Research Institute, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.pathol.2018.12.001DOI Listing
February 2019
2.188 Impact Factor

Improving the detection of familial hypercholesterolaemia.

Pathology 2019 Feb 19;51(2):213-221. Epub 2018 Dec 19.

Faculty of Health and Medical Sciences, School of Medicine, The University of Western Australia, Crawley, WA, Australia; Department of Cardiology, Lipid Disorders Clinic, Cardiometabolic Service, Royal Perth Hospital, Perth, WA, Australia; Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia; Department of Clinical Biochemistry, Australian Clinical Laboratories, Perth, WA, Australia. Electronic address:

Familial hypercholesterolaemia (FH) is a dominantly inherited disorder of low-density lipoprotein (LDL) catabolism, which if untreated causes lifelong elevated LDL-cholesterol (LDL-c), accelerated atherosclerosis and premature cardiovascular disease. Recent evidence suggests the prevalence of heterozygous FH is ∼1:220, making FH the most common autosomal dominant condition. Lowering LDL-c with statin and lifestyle therapy reduces the risk of cardiovascular events. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.015DOI Listing
February 2019

A Colonic Perineurioma.

Clin Med Insights Pathol 2018 6;11:1179555718815918. Epub 2018 Dec 6.

Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan.

Perineurioma is a mesenchymal neoplasm best known in soft-tissue pathology. A colonic perineurioma is a relatively recently described entity and sometimes encountered in specimens from the large intestine, especially distal colon. Without its recognition, a perineurioma can be misdiagnosed as other more common gastrointestinal spindle cell neoplasms. Read More

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http://dx.doi.org/10.1177/1179555718815918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295680PMC
December 2018
1 Read

The role of genetic testing in dyslipidaemia.

Pathology 2019 Feb 14;51(2):184-192. Epub 2018 Dec 14.

Departments of Medicine and Biochemistry, and Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address:

Dyslipidaemias encompass about two dozen relatively rare monogenic disorders and syndromes for which the genetic basis has largely been defined. In addition, the complex polygenic basis of disturbed lipids and lipoproteins has been characterised in many patients, and has been shown to result from accumulation of many common polymorphisms with small effects on lipids. Genetic technologies, including dedicated genotyping and sequencing methods can detect both rare and common DNA variants underlying dyslipidaemias. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.014DOI Listing
February 2019
1 Read

Nonfasting versus fasting lipid profile for cardiovascular risk prediction.

Pathology 2019 Feb 3;51(2):131-141. Epub 2018 Dec 3.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Before 2009 essentially all societies, guidelines, and statements required fasting before measuring a lipid profile for cardiovascular risk prediction. This was mainly due to the increase seen in triglycerides during a fat tolerance test. However, individuals eat much less fat during a normal day and nonfasting triglycerides have been shown to be superior to fasting in predicting cardiovascular risk. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.09.062DOI Listing
February 2019

PCSK9: from biology to clinical applications.

Pathology 2019 Feb 4;51(2):177-183. Epub 2018 Dec 4.

Laboratoire Inserm UMR 1188 DéTROI, Université de La Réunion, Sainte-Clotilde, France. Electronic address:

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial protein governing the circulating levels of low density lipoprotein-cholesterol (LDL-C), by virtue of its pivotal role in the degradation of the LDL receptor (LDLR). In the last 15 years, in vitro and in vivo studies have allowed our understanding of the physiological role of PCSK9. In the current report, we review the key studies that have established the mode of action of PCSK9, leading to the development of PCSK9 inhibitors for clinical use. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.012DOI Listing
February 2019
4 Reads

Digital pathology: semper ad meliora.

Authors:
Simone L Van Es

Pathology 2019 Jan 3;51(1):1-10. Epub 2018 Dec 3.

Department of Pathology, School of Medical Sciences, UNSW, Sydney, NSW, Australia. Electronic address:

This review is an evidence-based summary of digital pathology: past, present and future. It discusses digital surgical pathology and the cytopathology digitisation challenge as well as the performance of digital histopathology and cytopathology as a diagnostic tool, particularly in contrast to user perceptions. Time and cost efficiency of digital pathology, learning curves, education and quality assurance, with the importance of validation of systems, is emphasised. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183032
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http://dx.doi.org/10.1016/j.pathol.2018.10.011DOI Listing
January 2019
1 Read

Diet, exercise and weight loss and dyslipidaemia.

Authors:
Peter M Clifton

Pathology 2019 Feb 7;51(2):222-226. Epub 2018 Dec 7.

Alliance for Research in Exercise, Nutrition and Activity (ARENA), Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia. Electronic address:

There is a large amount of controversy relating dietary fat intake and coronary artery disease. It has been strongly suggested that saturated fat is not harmful and that polyunsaturated fat is either not beneficial or even harmful. Given that dietary lipids and fibre can influence serum lipids which are strongly linked to the risk of coronary artery disease I have reviewed recent evidence linking diet and serum lipids to confirm a diet-heart disease link. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.013DOI Listing
February 2019
1 Read

HTLV-1 is rare in Far North Queensland despite a significant burden of classically associated diseases.

Pathology 2019 Jan 28;51(1):91-94. Epub 2018 Nov 28.

Department of Medicine, Cairns Hospital, Cairns, Qld, Australia; The Kirby Institute, University of New South Wales, Kensington, NSW, Australia.

Human T-lymphotropic virus type 1 (HTLV-1) is hyperendemic amongst Indigenous Australians living in Central Australia. The epidemiology of the disease is poorly defined in other parts of Australia, despite a high prevalence of classically associated conditions. All HTLV-1 serology tests requested through public health facilities in Far North Queensland (FNQ) from January 1999 to December 2016 were reviewed. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.010DOI Listing
January 2019
1 Read

Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: a useful immunohistochemical approach for identification of neoplastic plasma cells.

Pathology 2019 Jan 29;51(1):81-85. Epub 2018 Nov 29.

Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address:

Plasma cell myeloma (PCM) is a haematological malignancy defined by aberrant proliferation of plasma cells in the bone marrow. For the diagnosis of PCM, immunostaining of light chains or surface marker analyses by flow cytometry is needed but sometimes difficult. Aberrant methylation at the carbon-5 position of cytosine results in 5-methylcytosine (5-mC), which is a well-known epigenetic hallmark of cancer in mammals. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.006DOI Listing
January 2019
1 Read

Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma.

Pathology 2019 Jan 28;51(1):67-73. Epub 2018 Nov 28.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Hong Kong. Electronic address:

Malignant transformation of benign mature ovarian teratoma can result in a wide spectrum of cancer, including a variety of carcinoma, sarcoma, or melanoma. The role of mismatch repair defects in such malignant transformation is still elusive. In view of current immunotherapy, the role of mismatch repair deficiency can have significant implications on therapeutic strategy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183034
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http://dx.doi.org/10.1016/j.pathol.2018.09.061DOI Listing
January 2019
10 Reads

MMP-9-1562 C/T single nucleotide polymorphism associates with increased MMP-9 level and activity during papillary thyroid carcinoma progression.

Pathology 2019 Jan 27;51(1):55-61. Epub 2018 Nov 27.

Institute for the Application of Nuclear Energy-INEP, University of Belgrade, Belgrade, Serbia. Electronic address:

Papillary thyroid carcinoma (PTC), a common form of thyroid malignancy, displays significant variations in clinical features and outcome. The malignant transformation of the thyroid is driven by altered expression of many matrix-modulating enzymes, including matrix metalloproteinase-9 (MMP-9). A single nucleotide polymorphism in its promotor (-1562 C/T) is suspected to cause overexpression of MMP-9, which in turn contributes to development of a tumour unfavourable phenotype. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.008DOI Listing
January 2019

Maternally expressed, paternally imprinted, embryonic non-coding RNA are expressed in osteosarcoma, Ewing sarcoma and spindle cell sarcoma.

Pathology 2019 Jan 27;51(1):113-116. Epub 2018 Nov 27.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom; Department of Clinical Biochemistry, Norfolk and Norwich University Hospital, Norwich Research Park, Norwich, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.08.014DOI Listing
January 2019

MMR protein immunohistochemistry and microsatellite instability in gastric cancers.

Pathology 2019 Jan 27;51(1):110-113. Epub 2018 Nov 27.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.09.057DOI Listing
January 2019

A high seroprevalence of human herpesvirus type 8 already present in patients with chronic hepatitis before the development of cirrhosis.

Pathology 2019 Jan 27;51(1):86-90. Epub 2018 Nov 27.

School of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Clinical Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi County, Taiwan; Department of Anatomic Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi County, Taiwan. Electronic address:

A high seroprevalence of human herpesvirus type 8 (HHV-8) in mild cirrhotics is significantly associated with hepatitis activity. Cirrhosis is always derived from chronic hepatitis. We aimed to evaluate the prevalence of HHV-8 infection in patients with chronic hepatitis. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.005DOI Listing
January 2019
10 Reads

Primary anorectal melanoma: clinical, immunohistology and DNA analysis of 43 cases.

Pathology 2019 Jan 26;51(1):39-45. Epub 2018 Nov 26.

Melanoma Institute Australia, The University of Sydney, Sydney, Australia; Royal Prince Alfred Hospital, Sydney, Australia; Sydney Medical School, The University of Sydney, Sydney, Australia. Electronic address:

Primary melanoma involving the anorectal region is rare, accounting for <1% of all melanomas in most Western countries. It characteristically presents at an advanced clinical stage and is associated with poor clinical outcomes. Preliminary reports suggest that response rates to immunotherapies in patients with advanced stage mucosal melanoma are much lower than in cutaneous (or acral) melanoma patients but reasons for this are unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183032
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http://dx.doi.org/10.1016/j.pathol.2018.09.060DOI Listing
January 2019
16 Reads

Cost-effective implementation of a custom MALDI-TOF library for the identification of South Australian Nocardia isolates.

Pathology 2018 Dec 25;50(7):753-757. Epub 2018 Oct 25.

SA Pathology, Department of Microbiology and Infectious Diseases, Adelaide, SA, Australia.

Mass spectrometry plays a significant role in the routine identification of micro-organisms and provides the ability to incorporate newly found pathogens into the database in a cost-effective fashion. This work aims to highlight the role of mass spectrometry through improved identification of Nocardia species in a diagnostic clinical microbiology laboratory. Prior to this study we constructed a custom in-house matrix-assisted laser desorption ionisation-time of flight (MALDI-TOF) library for Nocardia isolates consisting of isolates identified to the species level. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.08.006DOI Listing
December 2018

Blastic plasmacytoid dendritic cell neoplasm with immunoblastoid morphology and MYC rearrangement and overexpression.

Pathology 2019 Jan 24;51(1):100-102. Epub 2018 Nov 24.

Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.pathol.2018.09.058DOI Listing
January 2019

Acute Epstein-Barr virus hepatitis superimposed on drug induced liver injury causing severe hepatic dysfunction.

Pathology 2019 Jan 24;51(1):104-106. Epub 2018 Nov 24.

Australian Clinical Labs, Bella Vista, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.07.007DOI Listing
January 2019
1 Read

Chronic kidney cortical damage is associated with baseline kidney function and albuminuria in patients managed with radical nephrectomy for kidney tumours.

Pathology 2019 Jan 23;51(1):32-38. Epub 2018 Nov 23.

Princess Alexandra Hospital, Brisbane, Qld, Australia; Centre for Kidney Disease Research, University of Queensland, Brisbane, Qld, Australia; Translational Research Institute, Brisbane, Qld, Australia.

This study evaluated the relationship between histological markers of chronic kidney damage in patients undergoing radical nephrectomy for kidney tumours and preoperative kidney function, degree of albuminuria, and changes in glomerular volume. A schema to grade chronic kidney damage could be used to identify patients at risk of developing CKD following nephrectomy. Non-neoplastic cortical tissue was sourced from 150 patients undergoing radical nephrectomy for suspected kidney cancer. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.009DOI Listing
January 2019
13 Reads

Rhabdomyosarcoma with FUS re-arrangement: additional case in support of a novel subtype.

Pathology 2019 Jan 23;51(1):116-120. Epub 2018 Nov 23.

Department of Anatomical Pathology, PathWest, QEII Medical Centre, Nedlands, WA, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.09.056DOI Listing
January 2019

Dataset for the reporting of prostate carcinoma in core needle biopsy and transurethral resection and enucleation specimens: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Pathology 2019 Jan 23;51(1):11-20. Epub 2018 Nov 23.

Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

The International Collaboration on Cancer Reporting (ICCR) is a project which issues datasets and guidelines for international standardisation of cancer reporting. This review summarises the required and recommended elements of the datasets for prostate core needle biopsies and transurethral resection (TURP) and enucleation specimens of the prostate. To obtain as much information as possible from needle biopsies there should be only one core in each specimen jar with the exception of saturation biopsies. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.003DOI Listing
January 2019
1 Read
2.188 Impact Factor

High reproducibility is attainable in assessing histoprognostic parameters of pT1 colorectal cancer using routine histopathology slides and immunohistochemistry analyses.

Pathology 2019 Jan 23;51(1):46-54. Epub 2018 Nov 23.

CHRU Brest, Service d'Anatomie et Cytologie Pathologiques, Brest, France; Inserm U1053 BaRITOn, Bordeaux, France. Electronic address:

Assessment of the risk of lymph node invasion and tumour recurrence is critical to determine whether additional surgery is required in patients with endoscopically-removed pT1 colorectal cancer (CRC). A reproducible assessment of this risk of recurrence based on histopathological parameters is crucial for relevant therapeutic decisions. The inter-observer reproducibility of these parameters was the subject of our study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183030
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http://dx.doi.org/10.1016/j.pathol.2018.10.007DOI Listing
January 2019
8 Reads

Ectopic cervical well differentiated thymic carcinoma: report of a diagnostically challenging rare case.

Pathology 2019 Jan 23;51(1):122-125. Epub 2018 Nov 23.

Department of Pathology, National University Hospital, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.08.018DOI Listing
January 2019
1 Read

Overexpression of CDK7 is associated with unfavourable prognosis in oral squamous cell carcinoma.

Pathology 2019 Jan 22;51(1):74-80. Epub 2018 Nov 22.

Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Nanjing Medical University, Jiangsu, China. Electronic address:

Increased expression of cyclin-dependent kinase 7 (CDK7), an ubiquitous kinase associated with cell cycle and transcription, contributes to human tumourigenesis and associates with patients' prognosis. In the present study, we sought to investigate the expression pattern of CDK7 and its clinicopathological significance in primary oral squamous cell carcinoma (OSCC). The expression of CDK7 mRNA in OSCC was determined by data mining and interrogation using the Oncomine database. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.10.004DOI Listing
January 2019
4 Reads
2.188 Impact Factor

FDG-PET/CT findings, the vital clue to rare diagnosis of herpes simplex virus lymphadenitis simulating Richter transformation.

Pathology 2019 Jan 22;51(1):102-104. Epub 2018 Nov 22.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Vic, Australia; Epworth Healthcare, Melbourne, Vic, Australia; Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.08.016DOI Listing
January 2019

Uterine intravascular adenomyomatosis: a bizarre hybrid lesion?

Pathology 2019 Jan 22;51(1):120-122. Epub 2018 Nov 22.

Douglass Hanly Moir Pathology, Macquarie Park, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.07.009DOI Listing
January 2019
1 Read

Analysis of chromosome 12p over-representation and clinicopathological features in mediastinal teratomas.

Pathology 2019 Jan 20;51(1):62-66. Epub 2018 Nov 20.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Teratomas show diverse biologic behaviour and prognosis as well as variable histological features. Importantly, post-pubertal testicular teratomas composed of mature components have a potential for malignant behaviour, in contrast to ovarian dermoid cysts and pre-pubertal testicular teratomas which are considered almost always benign. On the other hand, the biological behaviour and histogenesis of extragonadal teratomas are still not fully elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183021
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http://dx.doi.org/10.1016/j.pathol.2018.10.002DOI Listing
January 2019
13 Reads

Human telomerase reverse transcriptase protein expression predicts tumour aggressiveness and survival in patients with clear cell renal cell carcinoma.

Pathology 2019 Jan 19;51(1):21-31. Epub 2018 Nov 19.

Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran; Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran.

Human telomerase reverse transcriptase (hTERT) is an active component of telomerase and responsible for its catalytic activity, associated with cell proliferation and differentiation. For the first time, the present study was conducted to evaluate the expression and prognostic significance of hTERT in different histological subtypes of renal cell carcinoma (RCC). Expression of hTERT was examined in 176 well-defined renal tumour samples including clear cell RCCs (ccRCCs), papillary and chromophobe RCCs using immunohistochemistry on tissue microarrays. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.08.019DOI Listing
January 2019
18 Reads

First report of homocystinuria-megaloblastic anaemia, cobalamin E complementation type, in an Indian child.

Pathology 2019 Jan 19;51(1):95-98. Epub 2018 Nov 19.

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.07.008DOI Listing
January 2019
9 Reads
2.188 Impact Factor

Parasitic nodules of thyroid: some insights into the origin and early evolution.

Authors:
Andrey Bychkov

Pathology 2019 Jan 16;51(1):125-127. Epub 2018 Nov 16.

Department of Pathology, Kameda Medical Center, Kamogawa, Chiba, Japan; Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.08.015DOI Listing
January 2019

Detection of OXA-carbapenemase-producing Enterobacteriaceae with chromID CARBA SMART screening plate.

Pathology 2019 Jan 16;51(1):108-110. Epub 2018 Nov 16.

Department of Laboratory Medicine, National University Hospital, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.08.017DOI Listing
January 2019
7 Reads

An insight into in vitro susceptibility of non-albicans Candida species from bloodstream infections to echinocandins in a Singapore cohort.

Pathology 2019 Jan 16;51(1):106-108. Epub 2018 Nov 16.

Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.07.010DOI Listing
January 2019
6 Reads

Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features.

Clin Med Insights Pathol 2018 4;11:1179555718809071. Epub 2018 Nov 4.

Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX, USA.

Central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL) is associated with a poor prognosis. However, prophylactic measures, including intrathecal (IT) methotrexate, reduce the incidence of CNS relapse in these patients considerably. Unfortunately, IT methotrexate can cause several neurologic complications, including transverse myelopathy; ie, the development of isolated spinal cord dysfunction over hours or days following the IT infusion of methotrexate, but in the absence of a compressive lesion. Read More

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http://dx.doi.org/10.1177/1179555718809071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236481PMC
November 2018
8 Reads

Activity of ceftolozane/tazobactam against a collection of Pseudomonas aeruginosa isolates from bloodstream infections in Australia.

Pathology 2018 Dec 2;50(7):748-752. Epub 2018 Nov 2.

UQ Centre for Clinical Research, The University of Queensland, Brisbane, Qld, Australia.

Pseudomonas aeruginosa is a common pathogen causing nosocomial infection. In particular, bloodstream infection (BSI) is associated with a high rate of morbidity and mortality. Ceftolozane/tazobactam is a new β-lactam/β-lactamase antimicrobial with activity against P. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.08.009DOI Listing
December 2018
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Evaluation of the role of Notch1 expression in hepatic carcinogenesis with clinico-pathological correlation.

Pathology 2018 Dec 30;50(7):730-736. Epub 2018 Oct 30.

Pathology Department, College of Medicine, Mansoura University, Mansoura, Egypt.

The role of Notch pathway in hepatocarcinogenesis is unclear with conflicting results reported from different researchers. This study aimed to investigate the exact role of Notch1 in hepatocarcinogenesis and its influence on survival and to determine the possibility of it being a target therapy. Differential immunohistochemical expression of Notch1 in 100 cases of hepatocellular carcinoma (HCC) and adjacent non-neoplastic liver tissue was performed. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.08.007DOI Listing
December 2018

Expression of EpCAM in adenoid cystic carcinoma.

Pathology 2018 Dec 30;50(7):737-741. Epub 2018 Oct 30.

Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

The mutational landscape of adenoid cystic carcinoma (ACC) is currently being revealed, but further studies are needed to identify biomarkers as therapeutic targets or prognostic factors of ACC. In this study, we investigated the expression of epithelial cell adhesion molecule (EpCAM) in ACCs. We retrospectively collected 83 cases of surgically resected ACCs. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.08.013DOI Listing
December 2018

EBV-positive diffuse large B-cell lymphoma features PD-L1 protein but not mRNA overexpression.

Pathology 2018 Dec 30;50(7):725-729. Epub 2018 Oct 30.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China. Electronic address:

Programmed cell death ligand 1 (PD-L1) is upregulated in various types of haematological malignancies and is associated with immunosuppression. This study aimed to investigate the expression pattern of PD-L1 in Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL). We retrospectively analysed clinicopathological characteristics in 30 cases of EBV-positive DLBCL and immunohistochemically evaluated the level of membrane bound PD-L1 protein. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.08.011DOI Listing
December 2018
10 Reads