6,376 results match your criteria Pathology[Journal]


Non-specific pleuritis: pathological patterns in benign pleuritis.

Pathology 2019 Apr 20. Epub 2019 Apr 20.

Department of Pneumonology and Thoracic Oncology, North Hospital, University Hospital of St-Etienne, France.

A pleural biopsy without granulomatous inflammation or tumour cells is interpreted as 'non-specific pleuritis' (NSP), a diagnosis without any specificity, often frustrating for physicians. However, varying histological features are found in NSPs with unknown significance. The aim of this study was to describe the detailed microscopic features of NSP and correlate them with the underlying aetiology. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.01.007DOI Listing

Imposter mucin: awareness of an important cytology artefact.

Pathology 2019 Apr 20. Epub 2019 Apr 20.

Anatomical Pathology, Austin Pathology, Heidelberg, Vic, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.12.422DOI Listing

Pulmonary epithelial myoepithelial carcinoma with papillary architecture: an uncommon morphology of a rare tumour.

Pathology 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.12.421DOI Listing

Fibrillin-1, a novel TGF-beta-induced factor, is preferentially expressed in metaplastic carcinoma with spindle sarcomatous metaplasia.

Pathology 2019 Apr 19. Epub 2019 Apr 19.

Graduate Institute of Pathology, National Taiwan University, Taipei, Taiwan.

TGF-β induces epithelial-mesenchymal transition (EMT), which is involved in tumour progression. This study aims to identify and characterise novel factors potentially related to TGF-β-mediated tumour aggression in breast cancer. We treated the human mammary epithelial cell line MCF10A with TGF-β and observed TGF-β-dependent upregulation of FBN1, involving demethylation of CpG sites, in MCF10A cells undergoing EMT. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.02.001DOI Listing

Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network.

Pathology 2019 Apr 19. Epub 2019 Apr 19.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

About 60-70% of hidradenoma papilliferum (HP), a benign tumour of the anogenital region, were recently described to harbour mutations in major driver genes of the PI3K/AKT/MAPK-signalling pathways. However, the underlying genetic defects of the non-mutant cases are still unknown. Using a 409 gene panel, we employed targeted next generation sequencing to investigate the mutational landscape in a cohort of seven PI3K/AKT-negative cases and five cases with known hotspot mutations in either PIK3CA or AKT1. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.01.010DOI Listing

HPV detection and genotyping of head and neck cancer biopsies by molecular testing with regard to the new oropharyngeal squamous cell carcinoma classification based on HPV status.

Pathology 2019 Apr 17. Epub 2019 Apr 17.

Laboratoire de virologie, Hôpital Européen Georges Pompidou, and Assistance Publique - Hôpitaux de Paris, Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes (Paris V), Sorbonne Paris Cité, Paris, France. Electronic address:

Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In practice, formalin-fixed, paraffin-embedded (FFPE) biopsy specimens are frequently the only available samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183059
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http://dx.doi.org/10.1016/j.pathol.2019.02.002DOI Listing
April 2019
4 Reads

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) in leukaemic phase without skin lesions: a diagnostic and management challenge.

Pathology 2019 Apr 16. Epub 2019 Apr 16.

Department Haematology, Royal Hobart Hospital, Hobart, Tas, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.11.016DOI Listing

Transthyretin Val122Ile amyloidosis associated with isolated gastrointestinal disease and bowel rupture in a Caucasian woman.

Pathology 2019 Apr 16. Epub 2019 Apr 16.

Haematology Department, Eastern Health, Victorian and Tasmanian Amyloidosis Service, Monash University Eastern Health Clinical School, Melbourne, Vic, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.12.423DOI Listing

Candida auris arriving on our shores: an Australian microbiology laboratory's experience.

Pathology 2019 Apr 16. Epub 2019 Apr 16.

Microbiology Department, Melbourne Health, Parkville, Vic, Australia; Pathology Department, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.

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http://dx.doi.org/10.1016/j.pathol.2019.01.009DOI Listing

First two confirmed cases of Dibothriocephalus nihonkaiensis in Southeast Asia (Singapore).

Pathology 2019 Apr 15. Epub 2019 Apr 15.

Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.pathol.2018.12.420DOI Listing

Is total iron binding capacity (TIBC) calculation correct?

Pathology 2019 Apr 15. Epub 2019 Apr 15.

The Royal College of Pathologists of Australasia Quality Assurance Program, St Leonards, NSW, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183048
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http://dx.doi.org/10.1016/j.pathol.2018.12.419DOI Listing
April 2019
1 Read

Increasing prevalence of methicillin-resistant Staphylococcus aureus in remote Australian communities: implications for patients and clinicians.

Pathology 2019 Apr 15. Epub 2019 Apr 15.

Division of Medicine, Cairns Hospital, Cairns, Qld, Australia; The Kirby Institute, University of New South Wales, Kensington, NSW, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.11.015DOI Listing

Insidious plumbum.

Pathology 2019 Apr 15. Epub 2019 Apr 15.

Department of Chemical Pathology, Pathology Queensland Central Laboratory, Brisbane, Qld, Australia; Faculty of Medicine, University of Queensland, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.11.017DOI Listing

Yersinia pseudotuberculosis bacteraemia: a diagnostic dilemma in the era of MALDI-TOF mass spectrometry.

Pathology 2019 Apr 15. Epub 2019 Apr 15.

Department of Microbiology and Infectious Diseases, SA Pathology, Adelaide, SA, Australia.

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http://dx.doi.org/10.1016/j.pathol.2019.01.006DOI Listing

Percentage grade 4 tumour predicts outcome for clear cell renal cell carcinoma.

Pathology 2019 Apr 12. Epub 2019 Apr 12.

Aquesta Specialised Uropathology, Brisbane, Qld, Australia; University of Queensland School of Medicine, Brisbane, Qld, Australia.

Heterogeneity of tumour grading is common in clear cell renal cell carcinoma (ccRCC). WHO/ISUP grading specifies that RCC should be graded based on the highest grade present in at least one high power field. This does not take into account the proportion of high grade tumour present in a cancer, which may itself influence outcome. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.01.004DOI Listing
April 2019
1 Read

Early treatment of acute promyelocytic leukaemia is accurately guided by the PML protein localisation pattern: real-life experience from a tertiary New Zealand centre.

Pathology 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology and Laboratory Medicine, LabPlus, Auckland City Hospital, Auckland, New Zealand; Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand. Electronic address:

Current guidelines recommend that a rapid test be used to assist diagnosis of acute promyelocytic leukaemia (APL), but the choice of an assay is discretionary. PML immunofluorescence (PML IF) identifies the microparticulate pattern of the PML protein localisation, highly specific for APL. The aim of this study was to evaluate clinical utility of PML IF in a real-life setting based on a retrospective records review for all patients who had PML IF performed in our centre between 2000 and 2017. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.01.003DOI Listing
March 2019
1 Read

Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.

Pathology 2019 Apr 8;51(3):274-280. Epub 2019 Mar 8.

Department of Chemical Pathology and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong. Electronic address:

Genetic defects on 6-pyruvoyl-tetrahydropterin synthase (PTPS) are the most prevalent cause of hyperphenylalaninaemia not due to phenylalanine hydrolyase deficiency (phenylketonuria). PTPS catalyses the second step of tetrahydrobiopterin (BH) cofactor biosynthesis, and its deficiency represents the most common form of BH deficiency. Untreated PTPS deficiency results in depletion of the neurotransmitters dopamine, catecholamine and serotonin causing neurological symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183042
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http://dx.doi.org/10.1016/j.pathol.2018.11.011DOI Listing
April 2019
5 Reads

An unusual case of undescended testis: type II persistent Müllerian duct syndrome.

Pathology 2019 Apr 7;51(3):335-336. Epub 2019 Mar 7.

Department of Chemical Pathology, Prince of Wales Hospital, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1016/j.pathol.2018.10.023DOI Listing

Australasian Gastrointestinal Pathology Society (AGPS) consensus guidelines for universal defective mismatch repair testing in colorectal carcinoma.

Pathology 2019 Apr 6;51(3):233-239. Epub 2019 Mar 6.

Envoi Specialist Pathologists, Brisbane, Qld, Australia; Faculty of Medicine, University of Queensland, Brisbane, Qld, Australia; Department of Pathology, University of Melbourne, Melbourne, Vic, Australia. Electronic address:

Lynch syndrome is the most common hereditary form of colorectal carcinoma caused by a constitutional pathogenic mutation in a DNA mismatch repair gene. Identifying Lynch syndrome is essential to initiate intensive surveillance program for the patient and affected relatives. On behalf of the Australasian Gastrointestinal Pathology Society (AGPS), we present in this manuscript consensus guidelines for Lynch syndrome screening in patients with colorectal carcinoma. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.014DOI Listing
April 2019
4 Reads

Laboratory validation studies in Ki-67 digital image analysis of breast carcinoma: a pathway to routine quality assurance.

Pathology 2019 Apr 6;51(3):246-252. Epub 2019 Mar 6.

Breast Subspecialty Unit, PathWest Laboratory Medicine, QEII Medical Centre and Fiona Stanley Hospital Sites, Perth, WA, Australia; School of Biomedical Science, UWA, Crawley, WA, Australia; Division of Pathology and Laboratory Medicine, Medical School, UWA, Crawley, WA, Australia. Electronic address:

Ki-67 proliferative index (PI) has prognostic and predictive value in invasive breast carcinoma (IBC), but clinical uptake has been hampered by suboptimal accuracy, reproducibility and standardisation. Published guidelines have addressed pre-analytical and analytical factors to improve Ki-67 PI utility; however, practicalities of ongoing monitoring of Ki-67 PI quality in IBC reporting have not been established. We aimed to evaluate the internal and external quality of our established digital Ki-67 PI IBC reporting practice at a tertiary institution. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.12.416DOI Listing
April 2019
1 Read

Identification of Fusobacterium nucleatum in formalin-fixed, paraffin-embedded placental tissues by 16S rRNA sequencing in a case of extremely preterm birth secondary to amniotic fluid infection.

Pathology 2019 04 5;51(3):320-322. Epub 2019 Mar 5.

Department of Pathology and Laboratory Medicine, University of Calgary Cumming School of Medicine, Calgary, Canada.

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http://dx.doi.org/10.1016/j.pathol.2018.11.013DOI Listing
April 2019
2 Reads

Biclonal presentation of lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia.

Pathology 2019 04 4;51(3):340-343. Epub 2019 Mar 4.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.10.022DOI Listing
April 2019
2.188 Impact Factor

Evaluation of the BioGX BD-Max PCR assay for detection of pathogenic Bordetella.

Pathology 2019 04 5;51(3):323-324. Epub 2019 Mar 5.

Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, NSW, Australia; Sydney Medical School, The University of Sydney, NSW, Australia; Centre for Infectious Diseases and Microbiology Laboratory Services, NSW Health Pathology, Sydney, NSW, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183035
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http://dx.doi.org/10.1016/j.pathol.2018.10.018DOI Listing
April 2019
3 Reads

Vancomycin dependent Enterococcus: an unusual mutant?

Pathology 2019 04 5;51(3):318-320. Epub 2019 Mar 5.

Department of Microbiology, The Canberra Hospital, Canberra, ACT, Australia; Department of Infectious Diseases, The Canberra Hospital, Canberra, ACT, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.11.012DOI Listing

Androgen receptor immunoexpression in triple-negative breast cancers: is it a prognostic factor?

Pathology 2019 Apr 5;51(3):327-329. Epub 2019 Mar 5.

Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia; Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, St Leonards, NSW, Australia; Sydney Medical School, University of Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.09.063DOI Listing

Concurrent anti-GBM disease and IgA glomerulonephritis.

Authors:
Anthony Longano

Pathology 2019 Apr 2;51(3):336-338. Epub 2019 Mar 2.

Department of Anatomical Pathology, Eastern Health, Box Hill Hospital, Box Hill, Vic, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.09.065DOI Listing
April 2019
1 Read

Clear cell sarcoma of the soft palate mimicking unclassified melanoma.

Pathology 2019 Apr 2;51(3):331-334. Epub 2019 Mar 2.

Département of Biopathology, Centre Leon Bérard, Lyon, France; UMR Inserm 1052 CNRS 5286, Centre Léon Bérard, Lyon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183038
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http://dx.doi.org/10.1016/j.pathol.2018.10.019DOI Listing
April 2019
4 Reads

Digital evaluation of proliferative 'hotspots' of more than 16,000 cells negatively impacts Ki-67 assessment in breast carcinoma.

Pathology 2019 Apr 2;51(3):329-331. Epub 2019 Mar 2.

Breast Subspecialty Group, Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, WA, Australia; Division of Pathology and Laboratory Medicine, Medical School, University of Western Australia, Crawley, WA, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.10.020DOI Listing
April 2019
2 Reads

Induction of peripheral lymph node addressin in human nasal mucosa with eosinophilic chronic rhinosinusitis.

Pathology 2019 Apr 2;51(3):268-273. Epub 2019 Mar 2.

Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan. Electronic address:

Eosinophilic chronic rhinosinusitis (ECRS) is characterised by formation of nasal polyps with prominent eosinophilic infiltration; however, how eosinophils are recruited in this pathological setting remains unclear. In the present study, we carried out quantitative immunohistochemical analysis of nasal polyps associated with ECRS (n=30) and non-ECRS (n=30) to evaluate expression of an L-selectin ligand peripheral lymph node addressin (PNAd) on vascular endothelial cells. We found that PNAd was induced primarily on the luminal surface of venular vessels present in nasal mucosa in both ECRS and non-ECRS, while the number of PNAd-expressing vessels in ECRS significantly exceeded that seen in non-ECRS. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.01.002DOI Listing
April 2019
1 Read

Patterns of p53 immunoreactivity in non-neoplastic and neoplastic Barrett's mucosa of the oesophagus: in-depth evaluation in endoscopic mucosal resections.

Pathology 2019 Apr 28;51(3):253-260. Epub 2019 Feb 28.

PathWest Laboratory Medicine, Perth, WA, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia.

There is increasing interest in p53 immunohistochemistry as an adjunct to haematoxylin and eosin (H&E) assessment for dysplasia in oesophageal Barrett's mucosa; however, published information on the patterns of staining remains scant. Here, we present descriptions of normal and aberrant p53 staining in non-neoplastic and dysplastic Barrett's mucosa in endoscopic mucosal resections. A retrospective series of archival endoscopic mucosal resections for biopsy proven dysplasia at our institution were retrieved for this study, comprising 28 sections from 23 patients. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.12.415DOI Listing

High Yes-associated protein 1 with concomitant negative LATS1/2 expression is associated with poor prognosis of advanced gastric cancer.

Pathology 2019 Apr 25;51(3):261-267. Epub 2019 Feb 25.

Department of Pathology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea. Electronic address:

The Hippo pathway is a tumour-suppressive pathway and its inactivation is known to be associated with progression and metastasis of various cancers. LATS1/2 (large tumour suppressor homolog 1 and 2), YAP1 (Yes-associated protein 1), and TEAD4 (TEA domain-containing sequence-specific transcription factors 4) are core components of the Hippo pathway, and their prognostic roles have not yet been studied in advanced gastric cancers (AGCs). A total of 318 surgically resected AGCs were retrieved. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.01.001DOI Listing

The epidemiology of Staphylococcus aureus skin and soft tissue infection in the southern Barkly region of Australia's Northern Territory in 2017.

Pathology 2019 Apr 25;51(3):308-312. Epub 2019 Feb 25.

Victorian Infectious Disease Service, The Royal Melbourne Hospital, and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia; Menzies School of Health Research, Darwin, NT, Australia.

The aim of this study was to describe the burden and organism antibiotic resistance patterns of skin and soft tissue infections (SSTI) due to Staphylococcus aureus presenting in a remote Australian Northern Territory community in the Barkly region. We collated reported antibiograms of all skin and superficial soft tissue swab specimens obtained from the town's Indigenous medical clinic from 12 of the 13 months between November 2016 and December 2017. Clinician's notes for the consultation associated with each test request were examined to determine the nature of the clinical problem and to access other relevant data. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.010DOI Listing
April 2019
6 Reads

NK-cell enteropathy, a potential diagnostic pitfall of intestinal lymphoproliferative disease.

Pathology 2019 04 26;51(3):338-340. Epub 2019 Feb 26.

Sydney Medical School, University of Sydney, NSW, Australia; Tissue Pathology and Diagnostic Oncology, ICPMR, Westmead Hospital, NSW, Australia.

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http://dx.doi.org/10.1016/j.pathol.2018.09.064DOI Listing

Diffuse inflammatory aneurysmal aortitis secondary to Scedosporium apiospermum complex in an immunocompetent individual.

Pathology 2019 04 26;51(3):316-318. Epub 2019 Feb 26.

Department of Immunology, PathWest, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; Medical School, University of Western Australia, Nedlands, WA, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.10.021DOI Listing

Choosing wisely in infectious serology: the merits of triaging send-away tests.

Pathology 2019 Apr 23;51(3):313-315. Epub 2019 Feb 23.

Wellington Southern Community Laboratory, Wellington Regional Hospital, Wellington, New Zealand.

Over-utilisation of pathology requests can incur unnecessary costs and be detrimental to patient care. The choosing wisely campaign has helped to reduce the use of tests with limited or no value. This report describes the estimated benefits and costs of implementing a triage process of infectious serology requests in a single mixed hospital and community laboratory. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.12.414DOI Listing

Measuring natural killer cell cytotoxicity by flow cytometry.

Pathology 2019 Apr 22;51(3):286-291. Epub 2019 Feb 22.

Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong Kong.

Natural killer (NK) cell cytotoxic function is critical in guarding an organism against viral infections and malignantly transformed cells. Although the Chromium (Cr)-release assay is regarded as the gold standard for assessing NK cell cytolytic activity, this method is associated with a number of technical problems including the use of radioactive reagents and inconsistent assay performance, due to the lack of assay standardisation across laboratories. Here we describe the setup of a flow cytometry (FC) based method for the measurement of NK cell cytotoxicity, suitable for patient testing. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.12.417DOI Listing

Indirect derivation of biological variation data and analytical performance specifications for therapeutic drug monitoring activities.

Pathology 2019 Apr 23;51(3):281-285. Epub 2019 Feb 23.

Department of Laboratory Medicine, National University Hospital, Singapore; Biomedical Institution for Global Health and Technology, National University of Singapore, Singapore. Electronic address:

We applied the indirect approach using anonymised data from an Australian and a Singapore laboratory to derive biological variation data for a group of 10 therapeutic drugs routinely monitored. A series of inclusion and exclusion criteria were applied on the data. The within- (CVi) and between-individual (CVg) biological variation data were then derived as previously described. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.12.418DOI Listing

Agreement of CK5/6, p40, and p63 immunoreactivity in non-small cell lung cancer.

Pathology 2019 Apr 21;51(3):240-245. Epub 2019 Feb 21.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

Histological subtyping of non-small cell lung cancer (NSCLC) is of utmost importance for therapy stratification. Common immunohistochemical markers to identify squamous lineage are CK5/6, p40, and p63. Although p40 is considered the gold standard by current guidelines, the agreement of all three markers is an important aspect for tumours more difficult to classify. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.009DOI Listing

Laboratory testing for lupus anticoagulant (LA) in patients taking direct oral anticoagulants (DOACs): potential for false positives and false negatives.

Pathology 2019 Apr 18;51(3):292-300. Epub 2019 Jan 18.

Department of Laboratory Haematology, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia; Sydney Centres for Thrombosis and Haemostasis, Sydney, NSW, Australia.

We and others have previously highlighted the potential problems with testing of lupus anticoagulants (LA) in patients on anticoagulant therapy, including most recently as related to the direct oral anticoagulants (DOACs). Thus, current DOACs in use (e.g. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.008DOI Listing
April 2019
3 Reads

HDL and cardiovascular disease.

Pathology 2019 Feb 3;51(2):142-147. Epub 2019 Jan 3.

South Australian Health and Medical Research Institute, Adelaide, SA, Australia.

High-density lipoprotein (HDL) has received increasing interest due to observations of an inverse relationship between its systemic levels and cardiovascular risk and targeted interventions in animal models that have had favourable effects on atherosclerotic plaque. In addition to its pivotal role in reverse cholesterol transport, HDL has been reported to possess a range of functional properties, which may exert a protective influence on inflammation, oxidation, angiogenesis and glucose homeostasis. This has led to the development of a range of HDL targeted therapeutics, which have undergone evaluation in clinical trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183051
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http://dx.doi.org/10.1016/j.pathol.2018.10.017DOI Listing
February 2019
9 Reads

Apheresis for severe hypercholesterolaemia and elevated lipoprotein(a).

Pathology 2019 Feb 2;51(2):227-232. Epub 2019 Jan 2.

Medical Department IV - Grosshadern, University Munich, Munich, Germany.

Low-density lipoprotein (LDL)-cholesterol (LDL-c) and lipoprotein(a) [Lp(a)] are independent cardiovascular risk factors. Reduction of LDL-c leads to reduction in cardiovascular events, regardless of the method of reducing LDL-c levels. Lifestyle modification and drugs are first line treatment options. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183039
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http://dx.doi.org/10.1016/j.pathol.2018.10.016DOI Listing
February 2019
2 Reads

Calreticulin mutation specific CAL2 immunohistochemistry accurately identifies rare calreticulin mutations in myeloproliferative neoplasms.

Pathology 2019 Apr 31;51(3):301-307. Epub 2018 Dec 31.

MTA-SE Momentum Molecular Oncohematology Research Group, Semmelweis University, 1st Department of Pathology and Experimental Cancer Research, Budapest, Hungary. Electronic address:

Mutations of the multifunctional protein calreticulin (CALR) are recognised as one of the main driver alterations involved in the pathogenesis of Philadelphia negative myeloproliferative neoplasms (Ph MPN) and also represent a major diagnostic criterion in the most recent World Health Organization classification of myeloid neoplasms. Nowadays, quantitative assessment of the driver mutations is gaining importance, as recent studies demonstrated the clinical relevance of the mutation load reflecting the size of the mutant clone. Here, we performed for the first time a manual and automated quantitative assessment of the CALR mutation load at protein level using CAL2, a recently developed CALR mutation specific monoclonal antibody, on a cohort of 117 patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF) and compared the CALR protein mutation loads with the CALR mutation load values established by a molecular assay. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183038
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http://dx.doi.org/10.1016/j.pathol.2018.11.007DOI Listing
April 2019
5 Reads

Update on the diagnosis, treatment and management of rare genetic lipid disorders.

Pathology 2019 Feb 28;51(2):193-201. Epub 2018 Dec 28.

School of Medicine, Faculty of Health & Medical Sciences, University of Western Australia, Perth, WA, Australia; Department of Clinical Biochemistry, PathWest Laboratory Medicine WA, Royal Perth Hospital & Fiona Stanley Hospital Network, Perth, WA, Australia. Electronic address:

Rare genetic lipid disorders affect the levels of cholesterol and/or triglyceride in the circulation and, if untreated, can often lead to severe multisystem complications. The field of rare lipid disorders is evolving and increasing awareness of these conditions, along with the systematic integration of recent advances or knowledge into clinical practice, is crucial to improve patient outcomes. The aim of this review is to provide an overview of selected rare genetic lipid disorders, focusing on the recommended diagnostic strategies and contemporary treatment and management options. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.005DOI Listing
February 2019
2.188 Impact Factor

Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease.

Authors:
A David Marais

Pathology 2019 Feb 28;51(2):165-176. Epub 2018 Dec 28.

Chemical Pathology Division, Pathology Department, University of Cape Town Health Science Faculty and National Health Laboratory Service, Cape Town, South Africa. Electronic address:

Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids, predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to mediate the clearance of their remnants after enzymatic lipolysis in the circulation. Its synthesis in macrophages initiates the formation of high density-like lipoproteins to effect reverse cholesterol transport to the liver. In the nervous system apoE forms similar lipoproteins which perform the function of distributing lipids amongst cells. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.002DOI Listing
February 2019
2 Reads

Lipodystrophies, dyslipidaemias and atherosclerotic cardiovascular disease.

Pathology 2019 Feb 27;51(2):202-212. Epub 2018 Dec 27.

Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Lipodystrophies are rare, heterogeneous, genetic or acquired, disorders characterised by varying degrees of body fat loss and associated metabolic complications, including insulin resistance, dyslipidaemias, hepatic steatosis and predisposition to atherosclerotic cardiovascular disease (ASCVD). The four main types of lipodystrophy, excluding antiretroviral therapy-induced lipodystrophy in HIV-infected patients, are congenital generalised lipodystrophy (CGL), familial partial lipodystrophy (FPLD), acquired generalised lipodystrophy (AGL) and acquired partial lipodystrophy (APL). This paper reviews the literature related to the prevalence of dyslipidaemias and ASCVD in patients with lipodystrophies. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402807PMC
February 2019
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Lipoprotein(a) catabolism: a case of multiple receptors.

Pathology 2019 Feb 27;51(2):155-164. Epub 2018 Dec 27.

Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria.

Lipoprotein(a) [Lp(a)] is an apolipoprotein B (apoB)-containing plasma lipoprotein similar in structure to low-density lipoprotein (LDL). Lp(a) is more complex than LDL due to the presence of apolipoprotein(a) [apo(a)], a large glycoprotein sharing extensive homology with plasminogen, which confers some unique properties onto Lp(a) particles. ApoB and apo(a) are essential for the assembly and catabolism of Lp(a); however, other proteins associated with the particle may modify its metabolism. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.11.003DOI Listing
February 2019
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2.188 Impact Factor

Non-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment.

Pathology 2019 Feb 27;51(2):148-154. Epub 2018 Dec 27.

School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia; Department of Clinical Biochemistry, Royal Perth Hospital and Fiona Stanley Hospital Network, PathWest Laboratory Medicine, Perth, WA, Australia. Electronic address:

Low density lipoprotein (LDL) is the predominant atherogenic lipoprotein particle in the circulation. Conventionally, a fasting lipid profile has been used for atherosclerotic cardiovascular disease (ASCVD) risk assessment. A non-fasting sample is now regarded as a suitable alternative to a fasting sample. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183059
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http://dx.doi.org/10.1016/j.pathol.2018.11.006DOI Listing
February 2019
7 Reads
2.188 Impact Factor

Lipids and cardiovascular disease.

Pathology 2019 Feb 27;51(2):129-130. Epub 2018 Dec 27.

Departments of Medicine and Biochemistry, Schulich School of Medicine and Robarts Research Institute, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.pathol.2018.12.001DOI Listing
February 2019
2.188 Impact Factor