209,036 results match your criteria Pathologic Assessment of Radical Prostatectomy


Impairment of the antifibrotic prostaglandin E pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium.

Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.

Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More

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November 2018
2 Reads

Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.

Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More

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December 2018

Micro-ATR FTIR, SEM-EDS and X-ray micro-CT: an innovative multi-technique approach to investigate bone affected by peri-implantitis.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: The aim of this work was to prove the synergic complementarity of attenuated total reflection Fourier transform infrared microspectroscopy (micro-ATR FTIR), scanning electron microscopy (SEM) coupled with energy-dispersive x-ray spectroscopy (EDS) and x-ray computed microtomography (micro-CT) by studying implant samples with bone affected by peri-implantitis.

Materials And Methods: Six samples of implanted bone affected by peri-implantitis and one control healthy bone were analyzed. Thick bone sections included in epoxy-resin and removed implants were analyzed by micro-ATR FTIR, SEM-EDS, and micro-CT. Read More

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December 2018

Accuracy of Right Upper Quadrant Ultrasound in Estimating Gallbladder Wall Thickness.

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Departments of Surgery.

Objective: Ultrasound (US) evaluation of biliary pathology can be influenced by a variety of factors. This study examines the effect of patient specific factors on the accuracy of sonographic evaluation of gallbladder wall thickness (GBW).

Methods: We performed a retrospective review of all patients who underwent cholecystectomy at a single institution from November 2012 to October 2015. Read More

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December 2018
1 Read

Why Does Postoperative Pancreatic Fistula Occur After Hand-sewn Parenchymal Closure and Staple Closure in Distal Pancreatectomy?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

Hand-sewing (HS) and stapling are common parenchymal closure techniques after distal pancreatectomy. However, these methods cannot completely prevent postoperative pancreatic fistula (POPF). The mechanisms of POPF formation after closure are unknown. Read More

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December 2018

Is it Necessary to Send the Sleeve Gastrectomy Specimens to Pathology?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Departments of General Surgery.

Background: Laparoscopic sleeve gastrectomy (LSG) has become more popular among other bariatric procedures. The histopathologic changes in the sleeve gastrectomy specimens have not been widely investigated among the Turkish population.

Objective: The purpose of this study was to delineate these histopathologic findings of the LSG specimens of morbidly obese patients from a single center. Read More

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December 2018

A Functional Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphism is Associated with Reduced Diffusing Capacity.

Am J Physiol Lung Cell Mol Physiol 2018 Dec 6. Epub 2018 Dec 6.

Pulmonary and Critical Care, Yale University School of Medicine, United States.

Cigarette smoke exposure is the leading modifiable risk factor for COPD, however the clinical and pathologic consequences of chronic cigarette smoke exposure are variable amongst smokers. MIF (Macrophage Migration Inhibitory Factor) is a pleiotropic cytokine implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Within the promoter of the MIF gene is a functional polymorphism that regulates MIF expression (-794 CATT microsatellite repeat) ( rs5844572). Read More

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December 2018

CD8-positive lymphomatoid papulosis (type D): Some lesions may lack CD30 expression and overlap histologically with mycosis fungoides.

Int J Dermatol 2018 Dec 6. Epub 2018 Dec 6.

School of Medicine, Indiana University, Indianapolis, IN, USA.

Background: CD8 lymphomatoid papulosis is frequently indistinguishable histopathologically from primary cutaneous aggressive epidermotropic CD8 T-cell lymphoma except for the expression of CD30. However, absent or weak expression of CD30 has been rarely reported in cases of CD8 LyP.

Objective: We aim to study the clinical and pathologic features of cases of CD8 LyP with no or minimal expression of CD30. Read More

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December 2018

Incidental Hepatic Tissue Obtained via Routine Cholecystectomy.

Int J Surg Pathol 2018 Dec 6:1066896918817374. Epub 2018 Dec 6.

2 University of California, Irvine, CA, USA.

Background: The hepatic tissue that may occupy specimens from routine cholecystectomies has yet to be studied. Our objectives were to determine the prevalence of hepatic tissue obtained at routine cholecystectomy, to determine whether such hepatic tissue can histologically withstand technical artifacts commonly associated with cholecystectomy, and to determine whether examining such hepatic tissue has diagnostic utility.

Materials And Methods: We retrospectively reviewed 50 specimens from routine cholecystectomies that were performed by surgeons who lacked knowledge of our study. Read More

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December 2018
1 Read

Potential of Exosomes for the Treatment of Stroke.

Cell Transplant 2018 Dec 6:963689718816990. Epub 2018 Dec 6.

1 Department of Anatomy, Histology and Embryology, Discipline of Neuroscience, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain barrier (BBB), and their important role in communication between cells. Read More

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December 2018
1 Read

A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation.

Biochemistry 2018 Dec 6. Epub 2018 Dec 6.

Ribonucleoprotein (RNP) condensations through liquid-liquid phase separation play vital roles in the dynamic formation-dissolution of stress granules (SGs). These condensations are, however, usually assumed to be linked to pathologic fibrillation. Here, we show that physiologic condensation and pathologic fibrillation of RNPs are independent processes that can be unlinked with the chemical chaperone trimethylamine N-oxide (TMAO). Read More

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December 2018

Prognostic Value of the Cycle Number of Perioperative Chemotherapy in Locoregionally Advanced Rectal Cancer: a Propensity Score Matching Analysis.

J Cancer 2018 21;9(23):4346-4354. Epub 2018 Oct 21.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center.

Appropriate cycle number of perioperative chemotherapy for patients with locoregionally advanced rectal cancer (LARC) remains unknown. This study aimed to evaluate how cycle number of perioperative chemotherapy influenced the prognosis of LARC patients. In this study, a total of 388 consecutive patients were enrolled and retrospectively reviewed if they were diagnosed with untreated stage cII-III LARC and treated with neoadjuvant chemoradiotherapy plus radical surgery followed by adjuvant chemotherapy or not. Read More

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October 2018

Patterns of regional nodal relapse after D2 lymphadenectomy in gastric cancer: rethinking the target volume.

Onco Targets Ther 2018 12;11:8015-8024. Epub 2018 Nov 12.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China,

Purpose: This study mapped the localization of regional nodal recurrence to determine whether the clinical target volume (CTV) should be redefined in adjuvant radiotherapy.

Patients And Methods: Between January 2004 and October 2015, a total of 129 patients with gastric cancer following D2 resection who experienced regional recurrence were retrospectively examined. The lymph nodes (LNs) were hand-drawn proportionally on template computed tomography (CT) images of a standard patient by referencing surrounding anatomic landmarks. Read More

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November 2018
1 Read

Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog.

Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.

Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More

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December 2018

SOCE and STIM1 signaling in the heart: Timing and location matter.

Cell Calcium 2018 Nov 27;77:20-28. Epub 2018 Nov 27.

Department of Medicine, Duke University School of Medicine, Durham, NC, United States.

Store operated Ca entry (SOCE) is an ancient and ubiquitous Ca signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to striated muscle was solidified with the description of skeletal myopathies that result from mutations in STIM1 and Orai1, the two SOCE components. Here, we consider the evidence for STIM1 and SOCE in cardiac muscle and the sinoatrial node. Read More

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November 2018

Cannabinoid receptor 2 agonist prevents local and systemic inflammatory bone destruction in rheumatoid arthritis.

J Bone Miner Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedics, The First Affiliated Hospital of Soochow University.

Cannabinoid receptor 2 (CB2) has been implicated as an important clinical regulator of inflammation and malignant osteolysis. Here, we observed that CB2 expression was markedly higher in the collagen-induced arthritis (CIA) mice synovium and bone tissues than in the non-inflamed synovium and bone tissues. The CB2 selective agonist (JWH133) but not antagonist (SR144528) suppressed CIA in mice without toxic effects, as demonstrated by the decreased synovial hyperplasia, inflammatory responses, cartilage damage, and periarticular and systemic bone destruction. Read More

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December 2018

Biomarkers and postoperative cognitive function: could it be that easy?

Curr Opin Anaesthesiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Anaesthesiology, University Hospital, LMU Munich, Munich.

Purpose Of Review: Neurocognitive dysfunction after surgery is highly relevant in the elderly. The multifactorial manner of this syndrome has made it hard to define an ideal biomarker to predict individual risk and assess diagnosis and severity of delirium [postoperative delirium (POD)] and subsequent postoperative cognitive decline (POCD). This review summarizes recent literature on blood biomarkers for POD/POCD. Read More

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November 2018

Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.

J Alzheimers Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA.

Little is known about the extracellular matrix (ECM) during progression of AD pathology. Brain ECM is abundant in hyaluronan (HA), a non-sulfated glycosaminoglycan synthesized by HA synthases (HAS) 1-3 in a high molecular weight (MW) form that is degraded into lower MW fragments. We hypothesized that pathologic severity of AD is associated with increases in HA and HA-associated ECM molecules. Read More

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November 2018

French translation and validation of the exercise-induced leg pain Questionnaire.

Disabil Rehabil 2018 Dec 3:1-6. Epub 2018 Dec 3.

c Department of Sport and Rehabilitation Sciences , University of Liège , Liège , Belgium.

Objective: The "Exercise-Induced Leg Pain" questionnaire was developed (in German) for the evaluation of the severity of symptoms and sports ability in individuals with exercise-induced leg pain. The purpose of the present study was to translate and cross-culturally adapt this questionnaire into French and to study the reliability and validity of this French-language version.

Methods: The translation and cross-cultural adaptation of the original "Exercise-Induced Leg Pain" was performed according to established guidelines. Read More

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December 2018
1 Read

Office treatment of large endometrial polyps using truclear 5C: Feasibility and acceptability.

J Obstet Gynaecol Res 2018 Dec 2. Epub 2018 Dec 2.

2nd Unit of Obstetrics and Gynecology, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.

Aim: This retrospective multicenter study was carried out to evaluate feasibility, effectiveness and patient acceptability of a small diameter hysteroscopic tissue removal system in the treatment of large endometrial polyps (≥20 mm), usually not removed in an office setting.

Methods: Hundred and forty-six women with a single greater than 10-mm diameter polyp considered for polypectomy between April 2016 and August 2017. Sixty-five of these patients had a polyp size greater than 20 mm. Read More

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December 2018
1 Read

The impact of 5-aminolevulinic acid on extent of resection in newly diagnosed high grade gliomas: a systematic review and single institutional experience.

J Neurooncol 2018 Dec 1. Epub 2018 Dec 1.

Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Health System, Detroit, MI, USA.

Background: Glioma surgery at its nascency relied predominantly on visual and tactile feedback for the removal of grossly abnormal tissue. This technique has inherent limitations in delineating infiltrative tumor from normal brain, thus limiting the ability to achieve a gross total resection consistently. Since extent of resection (EOR) is consistently correlated with measures of survival, fluorescence-guided surgery shows promise in improving our ability to treat high-grade gliomas (HGG). Read More

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December 2018

Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights.

Clin Rev Allergy Immunol 2018 Nov 30. Epub 2018 Nov 30.

Department of Respiratory Medicine & Allergology, Inst for Clinical Science, Lund University, Lund, Sweden.

Improving the lung function after experimental allergen challenge by blocking of mast cell (MC) mediators and the capability of MC mediators (including histamine, prostaglandin (PG) D2, and leukotriene (LT) C4) in induction of mucosal edema, bronchoconstriction, and mucus secretion provide evidence that MCs play a key role in pathophysiology of asthma. In asthma, the number of MCs increases in the airways and infiltration of MCs in a variety of anatomical sites including the epithelium, the submucosal glands, and the smooth muscle bundles occurs. MC localization within the ASM is accompanied with the hypertrophy and hyperplasia of the layer, and smooth muscle dysfunction that is mainly observed in forms of bronchial hyperresponsiveness, and variable airflow obstruction. Read More

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November 2018

Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease.

Authors:
Tanya M Laidlaw

World J Otorhinolaryngol Head Neck Surg 2018 Sep 5;4(3):162-168. Epub 2018 Sep 5.

Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, USA.

It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Samter's disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical symptoms, which usually involves nasal congestion, rhinorrhea, wheezing and bronchospasm. Gastrointestinal distress, nausea, a pruritic rash and angioedema can also occasionally develop. However, the underlying pathologic mechanism that drives these clinical reactions remains elusive. Read More

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September 2018
4 Reads

Impact of extra-axial cerebrospinal fluid collection in frontal morphology after surgical treatment of scaphocephaly.

Surg Neurol Int 2018 30;9:215. Epub 2018 Oct 30.

Departement of Pediatric Neurosurgery, Craniofacial Unit, Necker Enfants Malades Hospital, APHP, Paris, France.

Background: Infants with sagittal suture synostosis often present a pathologic dilatation of subarachnoid spaces. The impact of such subarachnoid spaces' enlargement in the morphology of the skull, especially on the forehead and on the surgical outcome, was analyzed.

Methods: Children less than 6 months of age undergoing a surgical correction of the scaphocephaly with Renier's H technique between 2003 and 2008 were included in the study. Read More

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October 2018

Correlation of tumor size and survival in pancreatic cancer.

J Gastrointest Oncol 2018 Oct;9(5):910-921

Department of Gastrointestinal Oncology, Sarasota Memorial Healthcare System, Sarasota, FL, USA.

Background: Neoadjuvant therapy (NT) for resectable pancreatic adenocarcinoma (PAC) continues to be debated. We sought to establish the relationship between pancreatic tumor size, neoadjuvant chemotherapy (NCT), neoadjuvant chemoradiation (NCRT), and definitive surgery (DS) on survival.

Methods: Utilizing the National Cancer Database we identified patients with PAC who underwent NT and DS. Read More

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October 2018
1 Read

Accuracy of endoscopic ultrasound staging for T2N0 esophageal cancer: a National Cancer Database analysis.

J Gastrointest Oncol 2018 Oct;9(5):887-893

Division of Surgical Oncology, Sarasota Memorial Hospital, Sarasota, FL, USA.

Background: To determine accuracy of clinical staging of T2N0 esophageal cancer from the National Cancer Database (NCDB).

Methods: The NCDB was accessed to identify patients with T2N0M0 esophageal cancer (adenocarcinoma or squamous cell carcinoma) treated between 2004-2013 that underwent esophagectomy. Pathologic staging was compared to clinical stage. Read More

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October 2018

Clinical fate of T0N1 esophageal cancer: results from the National Cancer Database.

J Gastrointest Oncol 2018 Oct;9(5):880-886

Sarasota Memorial Hospital, Florida State University College of Medicine, Sarasota, FL, USA.

The long-term survival for patients with locally advanced esophageal cancer (EC) remains poor despite improvements in multi-modality care. Neoadjuvant chemoradiation (NCR) followed by surgical resection remains pivotal in the management of patients with EC. However, the outcome of patients whose primary tumor exhibits a complete response with residual regional nodal disease (T0N1) remains unclear as well as the role for adjuvant therapy. Read More

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October 2018
1 Read

Differences in overall survival and mutation prevalence between right- and left-sided colorectal adenocarcinoma.

J Gastrointest Oncol 2018 Oct;9(5):778-784

Medical Oncology, Cancer Treatment Centers of America, Philadelphia, PA, USA.

Background: Prior reports have demonstrated inferior outcomes for patients with right-sided colorectal cancer (CRC) compared to patients with left-sided disease, as well as differences in treatment response based on disease sidedness. Differences in prognosis remain even among patients with metastatic disease, indicating that anatomy or stage at diagnosis alone cannot explain all of these findings. While genetic differences between right- and left-sided CRC have long been described, the genetic and molecular drivers underlying differences in prognosis and treatment response remain incompletely understood. Read More

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October 2018

Interstitial lung disease associated with anti-citrullinated peptide/protein antibody-positive anti-synthetase syndrome.

J Thorac Dis 2018 Oct;10(10):5924-5931

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanazawa-ku, Yokohama 236-0051, Japan.

Little has been reported on the characteristics of interstitial lung disease (ILD) associated with anti-citrullinated peptide/protein antibody (ACPA)-positive anti-synthetase syndrome (ASS). We sought to investigate the clinical, radiologic, and pathologic features of patients with ILD associated with ACPA-positive ASS. Medical records of seven ILD patients with positive results of both ACPA and anti-aminoacyl-tRNA synthetase antibody were retrospectively reviewed. Read More

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October 2018
1 Read

Prognostic factors in breast cancer patients evaluated by positron-emission tomography/computed tomography before neoadjuvant chemotherapy.

World J Nucl Med 2018 Oct-Dec;17(4):275-280

Department of Medicine, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26505, USA.

Neoadjuvant chemotherapy (NAC) is a significant modality in breast cancer therapy. We sought to characterize prognostic factors in patients scheduled for NAC who had a pretreatment positron-emission tomography paired with diagnostic quality contrast-enhanced computed tomography (CT) (positron-emission tomography/CT [PET/CT]). A total of 118 breast cancer patients were analyzed through chart review who underwent pretreatment PET/CT imaging and received NAC from 2008 to 2014. Read More

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December 2018
1 Read

The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity.

Authors:
Darja Kanduc

Biol Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, I-70124 Bari, Italy.

Analyses of the peptide sharing between five common human viruses (Borna disease virus, influenza A virus, measles virus, mumps virus and rubella virus) and the human proteome highlight a massive viral vs. human peptide overlap that is mathematically unexpected. Evolutionarily, the data underscore a strict relationship between viruses and the origin of eukaryotic cells. Read More

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December 2018
1 Read

What Is the Role of Elective Neck Dissection in the Management of Patients With Buccal Squamous Cell Carcinoma and Clinically Negative Neck Findings?

J Oral Maxillofac Surg 2018 Nov 7. Epub 2018 Nov 7.

Associate Professor and Chair, Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI.

Purpose: Buccal squamous cell carcinoma (BSCC) is rare in the United States. Given its location, few anatomic barriers to spread exist and it has been found to have a high locoregional recurrence rate. The role of elective neck dissection (END) in patients with clinically negative neck findings (N0) is not clear. Read More

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November 2018

Pathologic assessment after neoadjuvant chemotherapy for non-small cell lung cancer: Importance and implications of distinguishing adenocarcinoma from squamous cell carcinoma.

J Thorac Oncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: Major pathologic response (MPR) following neoadjuvant chemotherapy (NAC) for non-small cell lung cancer (NSCLC) has been defined as ≤10% residual viable tumor, without distinguishing between histologic types. We sought to investigate whether the optimal cutoff percentage of residual viable tumor for predicting survival differs between lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC).

Patients And Methods: Tumor slides from 272 patients treated with NAC and surgery for clinical stage II-III NSCLC (ADC, n=192; SCC, n=80) were reviewed. Read More

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November 2018
5.282 Impact Factor

Molecular and pathologic characterization of AML with double Inv(3)(q21q26.2).

Cancer Genet 2018 Nov 16. Epub 2018 Nov 16.

Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Pathology, UH Cleveland Medical Center, 10524 Euclid Ave, Cleveland, OH 44106, USA. Electronic address:

The inv(3)(q21q26.2) altering a single chromosome 3 homolog is an established myeloid malignancy-associated entity. Comparatively, double inv(3) cases involving both homologs are exceedingly rare with 13 reports across AML, CML and MDS. Read More

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November 2018

The fallopian tube, "precursor escape" and narrowing the knowledge gap to the origins of high-grade serous carcinoma.

Gynecol Oncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, United States of America. Electronic address:

Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. Read More

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November 2018
2 Reads

ypT0N+ status in oesophageal cancer patients: Location of residual metastatic lymph nodes with regards to the neoadjuvant radiation field.

Eur J Surg Oncol 2018 Nov 22. Epub 2018 Nov 22.

Department of Surgery, University Medical Center Utrecht, the Netherlands. Electronic address:

Introduction: A subset of oesophageal cancer patients has residual nodal disease despite complete pathologic response of the primary tumour after neoadjuvant chemoradiation and resection. The aim of this study was to determine the exact location of metastatic nodes with regard to the neoadjuvant radiation field and to assess progression-free (PFS) and overall survival (OS) in this group of patients.

Materials And Methods: From January 2010 to January 2017, complete tumour responders (ypT0) after neoadjuvant chemoradiotherapy and oesophagectomy were identified from a prospective database and grouped according to residual nodal disease (ypT0N + or ypT0N0). Read More

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November 2018

Phase II study of metabolic response to one-cycle chemotherapy in patients with locally advanced esophageal squamous cell carcinoma.

J Formos Med Assoc 2018 Nov 27. Epub 2018 Nov 27.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan; National Taiwan University Cancer Center, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, No 1, Jen Ai Road Section 1, Taipei, 10051, Taiwan. Electronic address:

Background: In the treatment of esophageal squamous cell carcinoma (ESCC), the optimal use of fluorodeoxyglucose positron emission tomography (PET) in measuring metabolic tumor response is undetermined. We launched a phase II trial to evaluate early metabolic response to one-cycle induction chemotherapy in patients with locally advanced ESCC.

Methods: ESCC patients in stage classification T3N0, N1M0, or M1a (American Joint Committee on Cancer, 6th edition) received one-cycle chemotherapy comprising paclitaxel, cisplatin, and 24-h infusional 5-fluorouracil and leucovorin on days 1 and 8, followed by neoadjuvant chemoradiotherapy, 40 Gy, with paclitaxel/cisplatin and then esophagectomy. Read More

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November 2018

Can post-hoc video review of robotic pancreaticoduodenectomy predict portal/superior mesenteric vein margin status in pancreatic adenocarcinoma?

HPB (Oxford) 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgery, University of Pittsburgh Medical Center, 5150 Center Ave, Pittsburgh, PA 15232, USA; Department of Surgery, West Virginia University, PO Box 9238 HSCS, Morgantown, WV 26506, USA. Electronic address:

Background: Achieving margin negative resection is a significant determinant of outcome in pancreatic adenocarcinoma (PDA). However, because of the fibrotic nature of PDA, it can be difficult to discriminate fibrosis from active disease intra-operatively. We sought to determine if post-hoc video review of robotic pancreatico-duodenectomy (RPD) could predict the portal/superior mesenteric vein (PV/SMV) margin status on final pathology. Read More

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November 2018
2 Reads

Prognostic value of pathologic complete response and the alteration of breast cancer immunohistochemical biomarkers after neoadjuvant chemotherapy.

Authors:
Yanjie Shuai Li Ma

Pathol Res Pract 2018 Nov 17. Epub 2018 Nov 17.

Hebei Medical University, Fourth Affiliated Hospital, Hebei Province Tumor Hospital, China. Electronic address:

Neoadjuvant chemotherapy(NCT) has become the standard treatment for breast cancer. The information about the tumor's sensitivity to chemotherapy and prognostic significance based on response to therapy can be provided after individualized neoadjuvant treatment. The biomarkers are key factors in the decision-making process regarding treatment as well as important prognostic indicators. Read More

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November 2018

[Relation of Thromboelastography with Coagulation Function and Plt Count in Different Coagulation States].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1793-1799

Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province,

Objective: To investigate the correlation and consistency between thromboelastography (TEG) and routine tests, platelets count in different coagulation states (hypercoagulable, low coagulation, and normal coagulation) and to evaluate the clinical value of TEG, routine bloot test and Plt count.

Methods: The clinical data of 409 patients performed the TEG, coaglation 4 test and blood routine test in third Xiangya Hosptial of Central Sonth University from January 2015 to December 2017 were analyzed retrospectively. The TEG main parameters such as the activation time of clothing factor (R), the formation rate of blood clots (K), the maximal α-angle (Angle) and maximal amplitude (MA) were compared with prothrombin time (PT), activated partial thromboplastin time (APTT), fibrin (Fib), thrombin time (TT) in blood routine test as well as platelet (Plt) counts by using the person correlation, Kappa consistency and paired chi-square test in different coagulation states, at the same time the guiding rote of these 2 detection mathods for clinical application of blood was compared. Read More

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December 2018

Mitophagy, a potential therapeutic target for stroke.

J Biomed Sci 2018 Nov 30;25(1):87. Epub 2018 Nov 30.

Heilongjiang University Of Chinese Medicine, Harbin, 150040, Heilongjiang province, China.

Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or excessive mitochondria that can generate reactive oxygen species (ROS) and cause cell death. Mitochondria are centrally implicated in neuron and tissue injury after stroke, due to the function of supplying adenosine triphosphate (ATP) to the tissue, regulating oxidative metabolism during the pathologic process, and contribution to apoptotic cell death after stroke. Read More

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November 2018

Differences in fetal growth patterns between twins and singletons.

J Matern Fetal Neonatal Med 2018 Dec 2:1-201. Epub 2018 Dec 2.

b Division of Maternal-Fetal Medicine , Department of Obstetrics and Gynecology , Sunnybrook Health Sciences Center , and University of Toronto , Toronto , Canada.

Objective: Twin fetuses growth is delayed during the third trimester compared to singletons. Whether this phenomenon should be considered a normal physiologic characteristic of twins or a pathologic process inherent to twin pregnancies is currently unclear. Information on the growth rate of the individual fetal biometric indices may provide more insight into the mechanisms underlying these differences between twins and singletons. Read More

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December 2018

Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)--1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression.

Molecules 2018 Nov 29;23(12). Epub 2018 Nov 29.

Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.

Osteoclasts are large multinucleated cells which are induced by the regulation of the receptor activator of nuclear factor kappa-Β ligand (RANKL), which is important in bone resorption. Excessive osteoclast differentiation can cause pathologic bone loss and destruction. Numerous studies have targeted molecules inhibiting RANKL signaling or bone resorption activity. Read More

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November 2018

Association of Prevalence of Benign Pathologic Findings After Partial Nephrectomy With Preoperative Imaging Patterns in the United States From 2007 to 2014.

JAMA Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Stanford University Medical Center, Stanford, California.

Importance: Although the intent of nephron-sparing surgery is to eradicate malignant tumors found on preoperative imaging, benign masses often cannot be differentiated from malignant tumors. However, in the past there have been discrepancies in the reported percentages of benign masses removed by partial nephrectomy (PNx).

Objective: To investigate the annual trend of prevalence of benign pathologic findings after PNx and to investigate what potential factors are associated with this prevalence. Read More

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December 2018

Can Presurgical Ultrasound Predict Survival in Women With Ovarian Masses?

Ultrasound Q 2018 Dec 3. Epub 2018 Dec 3.

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: This study aimed to determine the ability of ultrasound to predict survival and detect more aggressive tumors in women with ovarian masses.

Materials And Methods: Institutional review board approval was obtained. A total of 167 patients who presented with adnexal mass/masses were included. Read More

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December 2018
5 Reads

PET/CT and MR Features of Infiltrating Spinal Angiolipoma.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Sichuan, People's Republic of China.

Spinal angiolipomas are benign tumors predominantly found in the epidural space. Infiltrating spinal angiolipoma is an extremely rare type, which tends to invade the surrounding tissue and may mimic an aggressive tumor. Herein, we reported the case of a 64-year-old woman with a thoracic angiolipoma involving the T9 vertebral body and its appendix. Read More

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December 2018
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Malignant Lymphoma of the Ovary: A Diagnostic Pitfall of Intraoperative Consultation.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Departments of Obstetrics and Gynecology (N.I., Y.F., T.S., A.K., T.O., F.K.) Pathology (Y. Ikura, Y. Iwai) Hematology (M.O.), Takatsuki General Hospital, Takatsuki, Japan.

Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Read More

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December 2018
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[PROBLEMS OF IMPROVING ANTENATAL MONITORING OF PREGNANT WOMEN IN THE PRIMARY HEALTH CARE SYSTEM IN GEORGIA].

Georgian Med News 2018 Oct(283):1118-123

Universitty of Georgia; Tbilisi State University; Tbilisi Humanitarian Teaching University, Georgia.

The purpose of the above work is to study the trends of mothers' health condition according to the implementation of antenatal monitoring of primary healthcare programs in 1996 - 2016 in Georgia. The methodology basis of the research is the qualitative investigation, so called Desk Research: collecting statistical data, description, systematization, comparison, analyses and interpretation. Data about mothers' health indicators were derived from National Center for Disease Control and Social Health and National Service of Georgian Statistics. Read More

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October 2018
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Recurrent natural killer/T-cell lymphoma of the lacrimal sac and nasolacrimal duct in a 59-year-old Caucasian woman.

Orbit 2018 Dec 5:1-4. Epub 2018 Dec 5.

a Oculoplastic, Facial Cosmetic, and Orbital Surgery, Department of Ophthalmology and Visual Sciences , University of Wisconsin School of Medicine and Public Health , Madison , Wisconsin , United States.

A 59-year-old Caucasian woman with past medical history significant for Natural Killer (NK)/T-cell lymphoma of the right nasal septum in remission for nine months presented after surveillance PET-CT imaging revealed increased metabolic activity in the right nasolacrimal duct. She also reported ipsilateral epiphora starting around this time. The lacrimal sac and nasolacrimal ductal mucosa were biopsied via an external approach. Read More

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December 2018

Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification.

Calcif Tissue Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA.

Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs joint motion and function leading to loss of the ability to perform activities of daily living and pain. While soft tissue injury is a prerequisite of developing HO, the exact molecular pathology leading to trauma-induced HO remains unknown. Through prior investigations aimed at identifying the causative factors of HO, it has been suggested that additional predisposing factors that favor ossification within the injured soft tissues environment are required. Read More

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December 2018