5,265 results match your criteria Patent Foramen Ovale


Cryptogenic Stroke and Significance of the Patent Foramen Ovale: A Case Series.

Cureus 2018 Oct 30;10(10):e3525. Epub 2018 Oct 30.

Internal Medicine, University of Tennessee Health Science Center, Memphis, USA.

Stroke is the second leading cause of death globally and can lead to significant adverse outcomes in patients following the acute illness. Due to this high morbidity and mortality, adequate interventions can play a significant role in health outcomes. Patent foramen ovale is one of the major proposed causes of cryptogenic strokes and can be present in up to 25% of general population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318108PMC
October 2018

Anticoagulation in patients with Embolic Stroke of Unknown Source.

Authors:
J David Spence

Int J Stroke 2019 Jan 15:1747493019826363. Epub 2019 Jan 15.

Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.

When warfarin was the mainstay of anticoagulation for the prevention of cardioembolic stroke, the paradigm was essentially "we mustn't anticoagulate anyone unless we prove that the stroke was cardioembolic." Now that direct-acting oral anticoagulants are available, the paradigm should change. The risk of stroke is highest soon after the initial event, particularly in patients with more than one infarction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1747493019826363DOI Listing
January 2019

Stroke due to Paradoxical Embolization Related to Fibroid Uterus Enlargement Compressing the Right Common Iliac Vein.

Case Rep Neurol 2018 Sep-Dec;10(3):328-331. Epub 2018 Nov 23.

Department of Neurology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA.

Stroke in young women is commonly cryptogenic or associated with an underlying hypercoagulable state (e.g., hormonal contraception). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323390PMC
November 2018

Carcinoid heart disease involving the left heart: a case report and biomarker analysis.

ESC Heart Fail 2019 Jan 8. Epub 2019 Jan 8.

Department of Internal Medicine, Oberndorf Hospital, Salzburg, Austria.

Herein, we report the case of a 67-year-old woman who was admitted to our hospital because of dyspnoea and oedema of the lower extremities. Transthoracic echocardiography revealed severe tricuspid and mitral regurgitation, and the leaflets of the tricuspid valve were found to be rigid and almost immobile. The plasma concentrations of serotonin and chromogranin A were elevated, and hence, suspicion for carcinoid heart disease was raised. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ehf2.12396
Publisher Site
http://dx.doi.org/10.1002/ehf2.12396DOI Listing
January 2019
3 Reads

Interaction of cardiac implantable electronic device and patent foramen ovale in ischemic stroke: A case-only study.

Pacing Clin Electrophysiol 2019 Jan 8. Epub 2019 Jan 8.

Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri.

Background: Cardiovascular implantable electronic device (CIED) leads are a nidus for right atrial thrombi. Right-to-left thromboembolism across a patent foramen ovale (PFO) is a putative mechanism for ischemic stroke and PFO has been associated with stroke. We used a novel unbiased case-only study design to assess the effect modification of PFO-associated ischemic stroke risk by presence of CIED. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pace.13599
Publisher Site
http://dx.doi.org/10.1111/pace.13599DOI Listing
January 2019
1 Read

Prevalence and extent of right-to-left shunt on contrast-enhanced transcranial Doppler in patients with chronic hyperventilation syndrome: results of a case-control study.

Neurol Neurochir Pol 2019 Jan 7. Epub 2019 Jan 7.

Clinic of Neurology, Military Medical Institute, Szaserow 128, 04-141 Warsaw, Poland.

Aim: Chronic hyperventilation syndrome (CHVS) represents a frequent but poorly understood breathing pattern disorder. In a previous small pilot study, we reported a higher prevalence of right-to-left shunt (RLS) in CHVS patients than in healthy subjects. The aim of this study was to confirm previous results from this larger and matched case-control study and evaluate the prevalence and grade of RLS in patients with CHVS in whom organic and psychiatric causes were excluded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5603/PJNNS.a2019.0003DOI Listing
January 2019

Pediatric Acute Paradoxical Cerebral Embolism with Pulmonary Embolism Caused by Extremely Small Patent Foramen Ovale.

Open Med (Wars) 2019 24;14:10-13. Epub 2018 Dec 24.

Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.

Herein, we report a pediatric case of acute paradoxical cerebral embolism complicated by serious acute pulmonary embolism that was caused by an extremely small patent foramen ovale (PFO). The patient had no medical history suggestive of any other reason. Paradoxical cerebral embolism may occur even with an extremely small PFO because of the increased right-side pressure of the heart and a resulting right-to-left shunt from the acute pulmonary embolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2019-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310914PMC
December 2018

Paradoxical embolism caused by ovarian vein thrombosis extending to inferior vena cava in a female with uterine myoma.

J Cardiol Cases 2018 Dec 5;18(6):207-209. Epub 2018 Sep 5.

Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Deep vein thrombosis occasionally causes paradoxical embolism in patients with a patent foramen ovale (PFO). We report the case of a 42-year-old female who was hospitalized for stroke. Detailed investigations revealed the existence of a PFO, pulmonary embolism, and ovarian vein thrombosis extending to inferior vena cava. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jccase.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306514PMC
December 2018

Clinical Impact of Thrombophilia Screening in Young Adults with Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 27. Epub 2018 Dec 27.

Department of Neurology, Weill Cornell Medicine, New York, New York; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York. Electronic address:

Objective: We evaluated the ability of genetic and serological testing to diagnose clinically relevant thrombophilias in young adults with ischemic stroke.

Methods: We performed a retrospective cohort study of patients aged 18-65 years diagnosed with acute ischemic stroke at a comprehensive stroke center between 2011 and 2015 with laboratory testing for thrombophilia. The primary outcome was any positive thrombophilia screening test. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10523057183070
Publisher Site
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.006DOI Listing
December 2018
4 Reads

The best DEFENSE for high-risk patent foramen ovale: An updated meta-analysis of six randomized trials.

Arch Cardiovasc Dis 2018 Dec 26. Epub 2018 Dec 26.

Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, 10461 NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.acvd.2018.06.001DOI Listing
December 2018

Stroke in young adults: Five new things.

Neurol Clin Pract 2018 Dec;8(6):501-506

Division of Vascular Neurology (NB, AMM, SC), Department of Neurology, University of Miami Miller School of Medicine, and Miami VA Hospital (SC), FL.

Purpose Of Review: The incidence of stroke in young adults is increasing, mainly driven by an increasing incidence of ischemic stroke in this population. We provide new information that has been recently presented regarding the risk factor prevalence, some specific etiologic causes, and management strategies in ischemic stroke in this population.

Recent Findings: Recent studies indicate a rapid increase in traditional risk factors in young adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/CPJ.0000000000000522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294527PMC
December 2018

Paradoxical Embolism in a Patient with Patent Foramen Ovale; a Case Report.

Emerg (Tehran) 2018 8;6(1):e50. Epub 2018 Aug 8.

Department of Cardiology, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Patent foramen ovale (PFO) is usually asymptomatic; however, it could be quite dangerous for patients with right side clot in which thrombus can transmit the PFO and paradoxically emboli to systemic circulation. Here we present a patient with ankle fracture and paradoxical embolus to the brain, who was successfully treated with emergent thrombectomy, inferior vena cava (IVC) filter placement and anticoagulation therapy. Despite the high rate of mortality in these patients, fortunately our patient survived with surgical treatment. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289151PMC
August 2018
1 Read

Paradoxical embolism with thrombus stuck in a patent foramen ovale: a review of treatment strategies.

Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8885-8890

Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Objective: Paradoxical embolism represents a rare condition occurring when a thrombus originating from venous system produces pulmonary embolism and systemic embolization through an intracardiac or pulmonary shunt. The evidence of a thrombus entrapped in a patent foramen ovale (PFO) is an even more rare condition. There is uncertainty about the optimal treatment strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26355/eurrev_201812_16657DOI Listing
December 2018

Cryptogenic Stroke: To Close a Patent Foramen Ovale or Not to Close?

J Cent Nerv Syst Dis 2018 16;10:1179573518819476. Epub 2018 Dec 16.

Department of Medicine, The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

A patent foramen ovale (PFO) has been shown to be highly prevalent in patients diagnosed with strokes of unknown cause, which are also called cryptogenic strokes (CSs). It has been a long-running controversy as to whether a PFO should be closed or not to prevent recurrent strokes in patients diagnosed with CS. A paradoxical embolism that is produced through a PFO is hypothesized to be a leading cause of CS, especially in younger patients with low risk factors for stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179573518819476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297885PMC
December 2018

Response by Saver et al to Letter Regarding Article, "Patent Foramen Ovale Closure Versus Medical Therapy for Cryptogenic Ischemic Stroke: A Topical Review".

Stroke 2018 Dec;49(12):e336

Department of Neurology and Comprehensive Stroke Center, Tufts University School of Medicine, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.118.022688DOI Listing
December 2018

Clinical relevance of atrial septal aneurysm and patent foramen ovale with migraine.

World J Clin Cases 2018 Dec;6(15):916-921

Department of Structural Heart Disease, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an 710061, Shaanxi Province, China.

Aim: To test the potential association between atrial septal aneurysm (ASA) and migraine in patent foramen ovale (PFO) closure patients through an observational, single-center, case-controlled study.

Methods: We studied a total of 450 migraineurs who had right-to-left shunts and underwent PFO closure in a retrospective single-center non-randomized registry from February 2012 to October 2016 on the condition that they were aged 18-45 years old. Migraine was diagnosed according to the International Classification of Headache Disorders, 3 edition and evaluated using the Headache Impact Test-6 (HIT-6). Read More

View Article

Download full-text PDF

Source
http://www.wjgnet.com/2307-8960/full/v6/i15/916.htm
Publisher Site
http://dx.doi.org/10.12998/wjcc.v6.i15.916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288498PMC
December 2018
3 Reads

Tilting the balance: hemidiaphragm paralysis leading to right to left cardiac shunt.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Internal Medicine, Abington Hospital - Jefferson Health, Abington, Pennsylvania, USA.

Patent foramen ovale (PFO) is a congenital abnormality present in 25%-30% of healthy adults and rarely leads to any sequelae. It is associated with a left-to-right shunt which usually does not lead to any haemodynamic compromise. Occasionally, the shunt can get reversed; that is, right-to-left shunt occurs due to worsening pulmonary hypertension and can lead to persistent hypoxia. Read More

View Article

Download full-text PDF

Source
http://www.bmj.com/lookup/doi/10.1136/bcr-2018-227944
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-227944DOI Listing
December 2018
6 Reads

Morphological variations of the interatrial septum in ovine heart.

PLoS One 2018 19;13(12):e0209604. Epub 2018 Dec 19.

HEART-Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland.

Smooth septum interatrial septum, patent foramen ovale (PFO) channel and atrial septal pouches (SPs) are commonly described variants in humans. Recent discoveries on the clinical significance of left-sided SP may encourage the creation of new strategies and devices for the management of SPs. However, these strategies may first be tested in the ovine model before implementation in humans. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209604PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300291PMC
December 2018

Patent foramen ovale in an elderly male with multiple embolic infarcts.

Clin Case Rep 2018 Dec 26;6(12):2403-2406. Epub 2018 Oct 26.

Department of Neurology Haukeland University Hospital Bergen Norway.

Patent foramen ovale (PFO) is associated with embolic stroke, particularly in younger patients. In older patients, atrial fibrillation is a more common cause of embolic stroke. A PFO may be considered culpable at higher age when other potential embolic sources are absent or after recurrent stroke despite prophylactic treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.1852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293186PMC
December 2018

Neonatal Death Caused by Interrupted Aortic Arch Associated With 22q11.2 Deletion Syndrome: An Autopsy Case Report.

Am J Forensic Med Pathol 2018 Dec 17. Epub 2018 Dec 17.

Division of Genomic Medicine, Kanazawa Medical University, Ishikawa, Japan.

A case of clinically unsuspected fatal interrupted aortic arch (IAA) is described. A 17-day-old Japanese girl unexpectedly entered respiratory arrest at home. On autopsy, the heart was hypertrophic, with no apparent connection between the ascending and descending aortas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAF.0000000000000454DOI Listing
December 2018

Echocardiography guided bed side balloon atrial septostomy in dextro transposed great arteries (dTGA) with intact ventricular septum (IVS): A resource limited country experience.

Pak J Med Sci 2018 Nov-Dec;34(6):1347-1352

Najma Patel, FCPS, FSCAI, Professor and Head of the Department, Paediatric Cardiology, NICVD Karachi, Pakistan.

Objective: To determine effectiveness and safety of echocardiography guided bed side Balloon Atrial Septostomy (BAS) in dextro transposition of great Arteries (dTGA) with intact ventricular septum (IVS) at a public sector tertiary care hospital Karachi, Pakistan.

Methods: This case series include 40 patients with echocardiographic findings of dTGA with IVS and restricted PFO (≤ 2mm) who underwent bedside BAS at department of pediatric cardiology NICVD, Karachi, Pakistan. We recorded pre and post BAS diameter of PFO/Atrial Septal Defect (ASD), oxygen saturation (SpO %), and post procedure complications and outcome. Read More

View Article

Download full-text PDF

Source
http://pjms.com.pk/index.php/pjms/article/view/15792
Publisher Site
http://dx.doi.org/10.12669/pjms.346.15792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290203PMC
December 2018
4 Reads

Percutaneous patent foramen ovale closure during live case demonstrations.

Catheter Cardiovasc Interv 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, University Hospital of Bern, Bern, Switzerland.

Background: Live case demonstrations serve as an educational tool for interventional techniques in cardiology. The aim of this study was to assess the safety and technical success of percutaneous patent foramen ovale (PFO) closure during live case demonstrations.

Methods: All patients who had undergone percutaneous PFO closure with Amplatzer devices during live case demonstrations at our institution were consecutively included in this retrospective analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccd.28018DOI Listing
December 2018

Early Recurrent Ischemic Lesions in Patients With Cryptogenic Stroke and Patent Foramen Ovale: An Observational Study.

Front Neurol 2018 22;9:996. Epub 2018 Nov 22.

Klinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Randomized controlled trials indicate that patent foramen ovale (PFO) closure reduces risk of stroke recurrence in patients with cryptogenic stroke and PFO. However, the optimal time point for PFO closure is unknown and depends on the risk of stroke recurrence. We aimed to investigate risk of early new ischemic lesions on cerebral magnetic resonance imaging (MRI) in cryptogenic stroke patients with and without PFO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2018.00996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262074PMC
November 2018
1 Read

Fallacies of Evidence-Based Medicine in Cardiovascular Medicine.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Cardiology, University Heart Center, University Hospital of Zurich, Zurich, Switzerland.

Evidence-based medicine (EBM) has gained a dominant role as the backbone of modern medical activities since its definition about 20 years ago. It serves the purpose to unify and optimize patient management and minimize scientific bias and fraud. The article looks, in the realm of cardiovascular medicine, at the banes of overly rigorous application of EBM with insufficient counterbalancing of other decision criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjcard.2018.11.004DOI Listing
November 2018

Extreme exercise dislike of a toddler due to a patent foramen ovale.

Cardiol Young 2018 Dec 11:1-2. Epub 2018 Dec 11.

Fetal and Pediatric Cardiology,University Hospitals Leuven,Herestraat 49, 3000 Leuven,Belgium.

A 5-year-old girl presented with chronic fatigue and extreme exercise intolerance. After countless doctor visits, investigations, and hospital admissions, striking desaturation during exercise test pointed to a cardiovascular problem. Desaturation as a result of right-to-left shunting through a patent foramen ovale during upright exercise was hypothesised. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1047951118002044DOI Listing
December 2018
1 Read

Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

School of Health and Exercise Science, University of British Columbia, Canada.

Subjects with a patent foramen ovale (PFO) have blunted ventilatory acclimatization to high altitude, compared to subjects without PFO. The blunted response observed could be due to differences in central and/or peripheral respiratory chemoreflexes. We hypothesized that compared to subjects without a PFO (PFO-), subjects with a PFO (PFO+) would have blunted ventilatory responses to acute hypoxia and hypercapnia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00741.2018DOI Listing
December 2018
2 Reads

Microembolic signal detection by transcranial Doppler: Old method with a new indication.

World J Methodol 2018 Nov 29;8(3):40-43. Epub 2018 Nov 29.

Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.

Transcranial Doppler (TCD) is useful for investigation of intracranial arterial blood flow and can be used to detect a real-time embolic signal. Unfortunately, artefacts can mimic the embolic signal, complicating interpretation and necessitating expert-level opinion to distinguish the two. Resolving this situation is critical to achieve improved accuracy and utility of TCD for patients with disrupted intracranial arterial blood flow, such as stroke victims. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5662/wjm.v8.i3.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275557PMC
November 2018
1 Read

Transient Anarthria and Quadriplegia in a Patient with Basilar Artery Hypoplasia and Coincidental Intracranial Lipoma: A Case Report.

Case Rep Neurol 2018 Sep-Dec;10(3):322-327. Epub 2018 Nov 14.

Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Cerebral ischemia may be rarely associated with a hypoplastic vertebrobasilar system. Intracranial lipoma is also a very rare congenital malformation. We report the case of a 52-year-old woman with vertebrobasilar transient ischemic attack associated with basilar artery hypoplasia and coincidental intracranial lipoma. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/494323
Publisher Site
http://dx.doi.org/10.1159/000494323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276764PMC
November 2018
9 Reads

Interatrial shunting through an asymptomatic patent foramen ovale in thoracic surgery.

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Division of Thoracic Surgery, S. Maria della Misericordia Hospital, University of Perugia Medical School, Perugia, Italy.

Background: Patent foramen ovale (PFO) is present in up to 25% of the general population and is considered an irrelevant condition in healthy subjects. Here we sought to determine an association between the presence of an asymptomatic PFO at baseline and postoperative short-term adverse events in patients undergoing major pulmonary resection for lung cancer. As well, we evaluated for the rate of PFO after pulmonary resections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2018.10.054DOI Listing
November 2018
1 Read

Transcranial Doppler to detect right-to-left shunt in cryptogenic acute ischemic stroke.

Brain Behav 2018 Dec 1:e01091. Epub 2018 Dec 1.

Department of Neurology, Poitiers University Hospital, Poitiers Cedex, France.

Objectives: We aimed to confirm the sensitivity and specificity of contrast transcranial Doppler (cTCD) in the detection of right-to-left shunt (RLS) compared to the current reference standard (i.e., transesophageal echocardiography-TEE) in patients aged <55 years with a cryptogenic acute ischemic stroke (AIS) or high-risk (ABCD score ≥4) transient ischemic attack (TIA), and to calculate the real life delay in detecting RLS by cTCD versus TEE in a tertiary care academic stroke center. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/brb3.1091
Publisher Site
http://dx.doi.org/10.1002/brb3.1091DOI Listing
December 2018
12 Reads

[Obstructive sleep apnea-hypopnea and stroke].

Medicina (B Aires) 2018 ;78(6):427-435

Departamento de Medicina, Universitat Autónoma de Barcelona, Barcelona, España.

Stroke, one of the main causes of disability and death worldwide, is frequently associated to the obstructive sleep apnea-hypopnea syndrome. This sleep disorder has been demonstrated to be an independent risk factor for stroke, and therefore its investigation and treatment has been recommended for patients with stroke. Mechanisms relating these two clinical disorders include: oxidative stress, cerebral blood flow alterations, autonomic dysfunction, and hypercoagulability, as well as patent foramen ovale, blood pressure, and heart rhythm disorders. Read More

View Article

Download full-text PDF

Source
January 2018
1 Read

Hematopoietic cell transplantation for severe MPS I in the first six months of life: The heart of the matter.

Mol Genet Metab 2018 Nov 13. Epub 2018 Nov 13.

Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, United States.

Background: Hematopoietic cell transplantation (HCT) is accepted therapy for severe mucopolysaccharidosis type I (MPS IH). With implementation of newborn screening (NBS) for MPS I in the US, HCT may now occur earlier than 1-2 years of age and it might be assumed that cardiac issues will be fewer. To examine this hypothesis, we reviewed our records for any MPS IH infant who underwent HCT at ≤6 months of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2018.11.007DOI Listing
November 2018
1 Read

Updated Meta-analysis on the Closure of Patent Foramen Ovale in Reduction of Stroke Rates: the DEFENSE-PFO Trial Does not Change the Scenario.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):511-521

Department of Cardiovascular Surgery of the Pronto Socorro Cardiológico de Pernambuco (PROCAPE), Recife, PE, Brazil.

Objective: We aimed to analyze whether patent foramen ovale (PFO) closure reduces the risk of stroke, assessing also some safety outcomes after the publication of a new trial.

Introduction: The clinical benefit of closing a PFO has been an open question, so it is necessary to review the current state of published medical data in regards to this subject.

Methods: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles were used to search for randomized controlled trials (RCTs) that reported any of the following outcomes: stroke, death, major bleeding or atrial fibrillation. Read More

View Article

Download full-text PDF

Source
http://www.bjcvs.org/pdfRBCCV/v33n5a14.pdf
Publisher Site
http://dx.doi.org/10.21470/1678-9741-2018-0194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257535PMC
June 2018
4 Reads

Systemic Dissemination of Injected Foreign Material.

J Forensic Sci 2018 Dec 4. Epub 2018 Dec 4.

Forensic Science SA, GPO Box 2790, Adelaide, 5001.

A 32-year-old woman collapsed following an intravenous injection of material that included crushed pharmaceutical tablets. Resuscitation was attempted but was unsuccessful. She had an extensive past medical history of complications resulting from intravenous drug use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1556-4029.13970DOI Listing
December 2018
4 Reads

Antiplatelet therapy in valvular and structural heart disease interventions.

Cardiovasc Diagn Ther 2018 Oct;8(5):678-693

Unit of Cardiac Sciences, Campus Bio-Medico University of Rome, Rome, Italy.

Transcatheter interventions for valvular and structural heart diseases are rapidly expanding due to greater operators' experience and development of new generation devices associated with increased procedural safety. They represent the standard strategy for patients with prohibitive risk for open surgery. These procedures are associated with a significant occurrence of both thrombotic and bleeding complications, thus in this setting, even more than in other percutaneous procedures, the balance between thrombotic and bleeding risk is critical. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/cdt.2018.06.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232349PMC
October 2018

Embolization of Endocardial Vegetation With Stroke Presentation.

Am J Forensic Med Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC.

This case report details the unique cause of death of a 37-year-old Caucasian woman with a history significant for intravenous drug abuse. Before her death, she complained of extremity weakness and pain. Although her death was discovered to be the result of endocarditis, her symptoms were similar to that of a stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAF.0000000000000445DOI Listing
November 2018
6 Reads

Clinical and infarction patterns of PFO-related cryptogenic strokes and a prediction model.

Ann Clin Transl Neurol 2018 Nov 24;5(11):1323-1337. Epub 2018 Sep 24.

Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.

Objectives: The higher than expected PFO rate in CS patients has raised concerns that paradoxical embolism maybe the pathophysiologic mechanism for strokes. However, only a small proportion of pathogenic PFOs cause CS. Therefore, accurate recognition of patients with pathogenic PFOs among all CS patients could guide clinical decision making in selecting the most appropriate treatment. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/acn3.647
Publisher Site
http://dx.doi.org/10.1002/acn3.647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243387PMC
November 2018
9 Reads

Embolic stroke of undetermined source and patent foramen ovale closure: Practice insights from meta-analysis?

Catheter Cardiovasc Interv 2018 Nov;92(6):1161-1162

Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, Alabama.

Closure of patent foramen ovale (PFO) in embolic stroke of undetermined source (ESUS) reduces recurrent stroke compared with antiplatelet therapy in select patients but increases risk of atrial fibrillation. Device closure is an attractive option for young patients with an anatomically higher risk PFO and imaging proven ESUS. Benefit of PFO closure in ESUS compared with oral anticoagulation remains undefined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccd.27964DOI Listing
November 2018
1 Read

Ticagrelor for Refractory Migraine/Patent Foramen Ovale (TRACTOR): An open-label pilot study.

Neurology 2018 Nov;91(22):1010-1017

From the Herbert and Sandi Feinberg Interventional Cardiology and Heart Valve Center (A.M.R., B.T.R., L.P., T.N., R.J.S.) and Headache Center, Department of Neurology (D.E.C., M.S.Y., G.J.G.), New York-Presbyterian Hospital/Columbia University Medical Center, NY.

Objective: After finding that the thienopyridines clopidogrel and prasugrel reduced migraine headache (MHA) symptoms in some patients with patent foramen ovale (PFO), this small pilot study was undertaken to determine whether ticagrelor, a nonthienopyridine P2Y12 inhibitor, would have similar MHA effects and might be better suited for a future randomized trial.

Methods: MHA patients were screened for PFO. Participants with documented right to left shunt (RLS) and ≥6 monthly MHA days received ticagrelor therapy for 28 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006573DOI Listing
November 2018
8 Reads

Retrospective review of thienopyridine therapy in migraineurs with patent foramen ovale.

Neurology 2018 Nov;91(22):1002-1009

From the Herbert and Sandi Feinberg Interventional Cardiology and Heart Valve Center, New York-Presbyterian Hospital/Columbia University Medical Center, NY.

Objective: We retrospectively reviewed our clinical experience using off-label thienopyridine agents in patients with migraine headache (MHA) and patent foramen ovale (PFO).

Methods: Between 2011 and 2017, MHA/PFO patients referred to our practice were clinically treated with clopidogrel specifically for MHA. Those with ≥50% reduction in monthly MHA days compared with baseline were deemed MHA responders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006572DOI Listing
November 2018
14 Reads

Paradoxical embolism through PFO leading to stroke in a gunshot victim with IVC injury.

J Surg Case Rep 2018 Nov 19;2018(11):rjy308. Epub 2018 Nov 19.

Department of Surgery, UAMS, 4301W Markham St, Little Rock, AR, USA.

A 23-year-old man presented to the emergency department with multiple gunshot wounds to the chest and abdomen, and was taken to the operating room emergently for exploratory laparotomy due to hemodynamic instability. The patient underwent inferior vena cava (IVC), bowel and ureter repair during the procedure, requiring massive amounts of blood products. The patient transferred to the surgical intensive care unit with a routine post-operative course for approximately the next 7 days before presenting with signs of stroke. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjy30
Publisher Site
http://dx.doi.org/10.1093/jscr/rjy308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240738PMC
November 2018
12 Reads

Role of Transesophageal Echocardiography in Patients with Ischemic Stroke.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):456-467. Epub 2018 Nov 20.

John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA, United States of America.

Acute ischemic stroke is a condition with considerable mortality and morbidity. When used appropriately, Transesophageal Echocardiography (TEE) can be an incredibly useful tool to identify potential causes of stroke and guide management. The crucial distinction in this modality lies in separating common incidental findings from those likely to have contributed to ischemic stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pcad.2018.11.007DOI Listing
November 2018
5 Reads

[Efficacy and outcome of transcatheter closure of patent foramen ovale in patients with cryptogenic stroke].

Zhonghua Xin Xue Guan Bing Za Zhi 2018 Nov;46(11):882-886

Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

To investigate the efficacy and outcome of transcatheter patent foramen ovale (PFO) closure in patients with cryptogenic stroke (CS). Sixty consecutive patients with cryptogenic stroke who undertook transcatheter PFO closure between May 2015 and September 2017 in Beijing Tiantan Hospital were enrolled in this prospective study.Transcranial Doppler (TCD) bubble test was performed and right-left shunt(RLS) was confirmed in all patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-3758.2018.11.012DOI Listing
November 2018
4 Reads

[Is there to close the patent foramen ovale in time?]

Zhonghua Xin Xue Guan Bing Za Zhi 2018 Nov;46(11):846-848

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-3758.2018.11.006DOI Listing
November 2018

Percutaneous patent foramen ovale closure using the Occlutech Figulla device: More than 1,300 patient-years of follow up.

Catheter Cardiovasc Interv 2018 Nov 20. Epub 2018 Nov 20.

Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.

Objective: To evaluate the safety and efficacy of the Occlutech patent foramen ovale (PFO) device at long-term follow-up (FU).

Background: The Occlutech device has been proven safe and effective six-months after percutaneous PFO closure. We describe the safety and efficacy after more than 1,300 patient-years of FU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccd.27984DOI Listing
November 2018
6 Reads

State-of-the-Art Atrial Septal Defect Closure Devices for Congenital Heart.

Interv Cardiol Clin 2019 Jan;8(1):11-21

Division of Cardiology, UCLA Mattel Children's Hospital, University of California Los Angeles Medical School, 200 UCLA Medical Plaza #330, Los Angeles, CA 90095, USA.

This article describes current devices and indications for transcatheter device closure of atrial septal defect (TC-ASD) and patent foramen ovale in children and young adults. TC-ASD has a proven record of efficacy and safety, but device erosion raises questions about the relative safety of TC-ASD versus operative open heart surgical ASD closure. New devices for ASD closure with properties to reduce risk of erosion are being developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.iccl.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298220PMC
January 2019
15 Reads

A reversible cause of hypoxaemia in a patient with acute right ventricular infarction.

Hellenic J Cardiol 2018 Nov 15. Epub 2018 Nov 15.

Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hjc.2018.11.005DOI Listing
November 2018
1 Read

Thrombus "Squeezing" Through Patent Foramen Ovale After Traumatic Brain Injury.

Neurocrit Care 2018 Nov 16. Epub 2018 Nov 16.

Neuroscience Institute, The Queen's Medical Center, 1301 Punchbowl Street, Honolulu, HI, 96813, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12028-018-0646-1
Publisher Site
http://dx.doi.org/10.1007/s12028-018-0646-1DOI Listing
November 2018
4 Reads