6,471 results match your criteria Patent Foramen Ovale

From cryptogenic to ESUS: Toward precision medicine?

S Timsit

Rev Neurol (Paris) 2022 May 18. Epub 2022 May 18.

Université Brest, Inserm, EFS, UMR 1078, GGB, 29200 Brest, France; Neurology and Stroke unit Department, CHRU de Brest, Inserm1078, Université de Bretagne Occidentale, 29200 Brest, France. Electronic address:

Cryptogenic infarctions are infarctions without a defined cause, despite a complete work-up. They differ from infarctions of undetermined causes, which may involve overlapping causes or an incomplete investigation. It is also different from uncommon heritable and non-heritable causes. Read More

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A Prospective, Single-Center, Phase I Clinical Trial to Evaluate the Value of Transesophageal Echocardiography in the Closure of Patent Foramen Ovale With a Novel Biodegradable Occluder.

Front Cardiovasc Med 2022 3;9:849459. Epub 2022 May 3.

Department of Structural Heart Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Objective: Traditional metal alloy occluders for the closure of patent foramen ovale (PFO) may be associated with some potential complications, and may restrict the trans-septal access to the left atrium for future treatment of left-sided heart disease. Increasing attention has been paid to novel biodegradable occluders (NBOs) to achieve PFO closure. We aimed to evaluate the role of transesophageal echocardiography (TEE) in the diagnostic and anatomical evaluation of PFO, as well as in the Post-procedural assessment after transcatheter closure with a NBO. Read More

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Unexplained hypoxemia in COPD with cardiac shunt.

Respir Med Case Rep 2022 5;37:101661. Epub 2022 May 5.

Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Italy.

In Chronic Obstructive Pulmonary Disease (COPD), hypoxemia is associated with multiple underlying mechanisms, of which one of the most significant is ventilation-perfusion (V/Q) mismatch, which is correctable with supplemental oxygen (O) therapy. Hypoxemia that is refractory to very high concentration of inspired O can be indicative of cardiac defect with shunt, e.g. Read More

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Current Challenges and Future Directions in Handling Stroke Patients With Patent Foramen Ovale-A Brief Review.

Front Neurol 2022 28;13:855656. Epub 2022 Apr 28.

Department of Neurology, University of Leipzig, Leipzig, Germany.

The role of patent foramen ovale (PFO) in stroke was debated for decades. Randomized clinical trials (RCTs) have shown fewer recurrent events after PFO closure in patients with cryptogenic stroke (CS). However, in clinical practice, treating stroke patients with coexisting PFO raises some questions. Read More

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Editorial commentary: Atrial septal aneurysm as a risk factor for ischemic stroke with patent foramen ovale.

Yuji Ueno

Trends Cardiovasc Med 2022 May 11. Epub 2022 May 11.

Department of Neurology, Juntendo University Faculty of Medicine, Tokyo, Japan. Electronic address:

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Percutaneous Closure of Patent Foramen Ovale after Anterior Spinal Cord Infarction.

Case Rep Cardiol 2022 20;2022:2171350. Epub 2022 Apr 20.

Department of Pediatric Cardiology, Hospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

In patients with a patent foramen (PFO) who have had a cryptogenic ischemic stroke, percutaneous closure reduces its recurrence risk. However, its role in spinal cord infarction (SCI) is less well-established. A few case reports describe the putative causative role of PFO in SCI. Read More

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Cardiovascular manifestation of end-stage liver disease and perioperative echocardiography for liver transplantation: anesthesiologist's view.

Anesth Pain Med (Seoul) 2022 Apr 22;17(2):132-144. Epub 2022 Apr 22.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Liver transplantation (LT) is the curative therapy for decompensated cirrhosis. However, anesthesiologists can find it challenging to manage patients undergoing LT due to the underlying pathologic conditions of patients with end-stage liver disease and the high invasiveness of the procedure, which is frequently accompanied by massive blood loss. Echocardiography is a non-invasive or semi-invasive imaging tool that provides real-time information about the structural and functional status of the heart and is considered to be able to improve outcomes by enabling accurate and detailed assessments. Read More

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Impact of dose reducing software on patient and staff temple dose during fluoroscopically guided pacemaker insertion, closure devices implantation and coronary angiography procedures.

Phys Eng Sci Med 2022 May 9. Epub 2022 May 9.

School of Chemistry and Physics, Faulty of Science, Queensland University of Technology, 2 George Street, Brisbane, QLD, 4000, Australia.

The aim of this study is to investigate the effectiveness of dose reducing software (ClarityIQ) on patient and staff dose during fluoroscopically guided cardiac procedures. Dose measurements were collected in a room without dose reducing software (n = 157) and compared with similar procedures performed in two rooms with the software (n = 1141). Procedures included diagnostic coronary angiography, percutaneous coronary intervention, deployment of cardiac closure devices (for occlusion of atrial septal defect, patent foramen ovale, and atrial appendage) and insertion of permanent pacemakers. Read More

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Clinical Status and Outcome of Isolated Right Ventricular Hypoplasia: A Systematic Review and Pooled Analysis of Case Reports.

Front Pediatr 2022 21;10:794053. Epub 2022 Apr 21.

Department of Pediatrics, International University of Health and Welfare, Tokyo, Japan.

Background: Isolated right ventricular hypoplasia (IRVH), not associated with severe pulmonary or tricuspid valve malformation, is a rare congenital myocardial disease. This study aims to evaluate the clinical status and outcome of IRVH.

Methods: A systematic search of keywords on IRVH was conducted. Read More

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Novel Heterozygous Missense Variant in GRIA4 Gene Associated With Neurodevelopmental Disorder With or Without Seizures and Gait Abnormalities.

Front Genet 2022 20;13:859140. Epub 2022 Apr 20.

Chigene (Beijing) Translational Medical Research Center Co., Ltd., Beijing, China.

Neurodevelopmental disorder with or without seizure and gait abnormalities (NEDSGA, MIM * 617864) is a newly described autosomal dominant inherited disease caused by a heterozygous variant in the GRIA4 gene. plays an essential role in excitatory synaptic transmission. In this study, we presented the clinical and genetic features of a female patient carrying a novel variant in and further reviewed the previously reported five different patients. Read More

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[Bilateral paramedian thalamic infraction due artery of Percheron occlusion].

Andes Pediatr 2021 Dec 8;92(6):924-929. Epub 2021 Sep 8.

Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Introduction: Artery of Percheron (AOP) is an anatomical variant responsible for the bilateral irrigation of both the medial thalami and rostral sector of the brainstem. Its obstruction causes infarcts in these areas.

Objective: To describe a clinical case of AOP infarction, highlighting the clinical and imaging fin dings to consider this pathology in the pediatric population with acute altered state of consciousness. Read More

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December 2021

Short-term results of percutaneous closure of a patent foramen ovale guided by transoesophageal echocardiography in patients with cryptogenic stroke: a retrospective study.

J Cardiothorac Surg 2022 May 3;17(1):96. Epub 2022 May 3.

Department of Cardiovascular Surgery, The Second Affiliated Hospital of Hainan Medical University, 48th of Bai Shui Tang Road, Haikou, Hainan, 570311, People's Republic of China.

Background: A patent foramen ovale (PFO) is a risk factor for cryptogenic stroke (CS), and interventional therapy for PFO can reduce the recurrence rate of CS. However, interventional therapies are primarily guided by X-ray imaging, and data on regular post-surgical follow-up with the transthoracic ultrasound foaming test (UFT) are rare. Thus, this study aimed to assess the short-term (12 months) results of PFO occlusion guided by transoesophageal echocardiography (TEE) and the results of regular UFTs. Read More

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Acute Lymphoblastic Leukemia in Combined Methylmalonic Acidemia and Homocysteinemia (cblC Type): A Case Report and Literature Review.

Front Genet 2022 14;13:856552. Epub 2022 Apr 14.

Department of Pediatrics, The First Hospital of China Medical University, Shenyang, China.

Methylmalonic acidemia (MMA) can display many clinical manifestations, among which acute lymphoblastic leukemia (ALL) has not been reported, and congenital heart disease (CHD) is also rare. We report an MMA case with ALL and CHD in a 5.5-year-old girl. Read More

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[Risk factors for syncope in children with severe idiopathic pulmonary arterial hypertension].

Zhonghua Er Ke Za Zhi 2022 May;60(5):442-446

Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.

To explore the risk factors for syncope in children with severe idiopathic pulmonary arterial hypertension (IPAH). Forty-four patients (age<18 years) with IPAH admitted to the Department of Pediatric Cardiology, Beijing Anzhen Hospital between May 2011 and October 2021 were retrospectively included. Patients were devided into syncope group and non-syncope group. Read More

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A rare congenital anomaly: Anomalous fibromuscular cord of the left atrium.

J Card Surg 2022 Apr 26. Epub 2022 Apr 26.

Department of Echocardiography, Wuhan Asia Heart Hospital, Wuhan, Hubei, P.R. China.

Background: Left atrial anomalous fibromuscular cord is a rare congenital anomaly, which exists in a small proportion of the general population. Although its clinical significance remains largely unknown, it is generally considered a benign entity. We report a case of incidental finding of left atrial fibromuscular cord without structural cardiac abnormalities or hemodynamic obstruction. Read More

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High prevalence of patent foramen ovale in recreational to elite breath hold divers.

J Sci Med Sport 2022 Mar 26. Epub 2022 Mar 26.

Department of Human Physiology, University of Oregon, United States of America.

Objectives: During apnea diving, a patent foramen ovale may function as a pressure relief valve under conditions of high pulmonary pressure, preserving left-ventricular output. Patent foramen ovale prevalence in apneic divers has not been previously reported. We aimed to determine the prevalence of patent foramen ovale in apneic divers compared to non-divers. Read More

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Pulmonary Embolism in Transit Across a Patent Foramen Ovale.

Cureus 2022 Mar 10;14(3):e23026. Epub 2022 Mar 10.

Cardiology, Western Reserve Hospital, Cuyahoga Falls, USA.

A pulmonary embolism (PE) is an obstruction in a pulmonary artery, and a saddle PE occurs when the obstruction is lodged in the main pulmonary trunk and spans the left and right pulmonary arteries. The current case study describes complications of a thrombus in transit across a patent foramen ovale (PFO). A 35-year-old female presented to the emergency department after a nontraumatic syncopal fall. Read More

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Differences in Cardiac Etiologies for Ischemic Stroke in Young and Middle-Aged Patients: A Single-Center Experience in Taiwan.

Wen-Hwa Wang

J Clin Med 2022 Apr 11;11(8). Epub 2022 Apr 11.

Department of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.

Background: The cardiac etiology of acute ischemic stroke (AIS) plays an important role in young adults; therefore, complete cardiac workups and subsequent prevention methods are important for treating young AIS patients. However, the definition of a young age for AIS patients could be below 45 years old, while in some previous studies, it has been below 55 years old. It remains unclear whether cardiac workups are equally important for AIS patients in the young (the age of 20-45 years old) and middle-aged (46-55 years old) categories. Read More

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Aortic Root Downward Movement as a Novel Method for Identification of an Adequately Performed Valsalva Maneuver to Detect Patent Foramen Ovale during Transesophageal Echocardiograph.

Diagnostics (Basel) 2022 Apr 13;12(4). Epub 2022 Apr 13.

Shenzhen Medical Ultrasound Engineering Center, Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China.

The Valsalva maneuver (VM) is the most sensitive auxiliary method for the detection of patent foramen ovale (PFO), but it is difficult to assess whether the maneuver is adequately performed during transesophageal echocardiography (TEE). In this study, we tried to use aortic root downward movement as a novel method for judging whether VM was adequate or not, and to evaluate whether this novel method can increase the sensitivity of detecting PFO. A total of 224 patients with clinically suspected PFO were enrolled in this study. Read More

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Changing of Left Atrial Function Index in Symptomatic Patients with Patent Foramen Ovale After Device Closure.

Turk Kardiyol Dern Ars 2022 Apr;50(3):175-181

Division of Cardiology, Rovigo General Hospital, Rovigo, Italy.

Background: Left atrial function is impaired in patients with patent foramen ovale. This study aimed to evaluate the role of left atrial function index in monitoring the course of left atrial function in a patient with patent foramen ovale before and after percutaneous closure.

Methods: We retrospectively reviewed the findings of consecutive patients evaluated in our tertiary center for patent foramen ovale closure to identify those subjects with acute ischemic stroke, transient ischemic attack, or radiological evidence of cerebral ischemic events (index event) who performed a complete echocardiography evaluation reporting evidence of patent foramen ovale between September 2004 and September 2018. Read More

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Is patent foramen ovale the cause of stroke in a patient with moyamoya disease?

Cardiol Young 2022 Apr 22:1-3. Epub 2022 Apr 22.

Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China.

We reported a case of ischaemic stroke with moyamoya disease with simultaneous occurrence of patent foramen ovale. The patient underwent percutaneous closure of patent foramen ovale and was scheduled for follow-up. Read More

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Retinal vascular occlusion in pregnancy: three case reports and a review of the literature.

J Med Case Rep 2022 Apr 21;16(1):167. Epub 2022 Apr 21.

Department of Ophthalmology, University of Duesseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.

Background: Retinal arterial occlusive events in young patients are rare. However, because of physiological multifactorial adaptations during pregnancy, retinal vascular occlusive disease may occur spontaneously. In addition, a patent foramen ovale is a risk factor for an ischemic thromboembolic event. Read More

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Characteristics of Patent Foramen Ovale: Analysis from a Single Center.

Cardiol Res Pract 2022 6;2022:5430598. Epub 2022 Apr 6.

Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Objective: To collect and analyze data of patent foramen ovale (PFO).

Methods: This study included a total of 260 patients diagnosed with PFO. We analyzed basic clinical data such as sex, age, transesophageal echocardiography as well as other symptoms. Read More

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Incidence of new-onset atrial fibrillation after transcatheter patent foramen ovale closure using 15 years of Ontario administrative health data.

Heart Rhythm 2022 Apr 13. Epub 2022 Apr 13.

Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, University Health Network (UHN), Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Background: Individuals with patent foramen ovale (PFO) routinely undergo transcatheter closure (TC) for secondary prevention of recurrent stroke. However, some evidence suggests that TC may increase the risk of new-onset atrial fibrillation (AF).

Objective: The purpose of this study was to evaluate the risk of new-onset AF following PFO closure and to explore predictors of AF development. Read More

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Advances in Recurrent Stroke Prevention: Focus on Antithrombotic Therapies.

Circ Res 2022 Apr 14;130(8):1075-1094. Epub 2022 Apr 14.

Department of Neurology, University of Maryland, Baltimore, MD (S.C.).

The past decade has seen significant advances in stroke prevention. These advances include new antithrombotic agents, new options for dyslipidemia treatment, and novel techniques for surgical stroke prevention. In addition, there is greater recognition of the benefits of multifaceted interventions, including the role of physical activity and dietary modification. Read More

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Embolic Stroke in Setting of Iliac Vein Stenosis in an Avid Cyclist.

Neurohospitalist 2022 Apr 20;12(2):413-416. Epub 2022 Feb 20.

Department of Neurology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ, USA.

External iliac vein stenosis related to cycling has rarely been reported as a cause of deep vein thrombosis. Ischemic stroke occurring in this condition due to paradoxical embolism across a preexisting patent foramen ovale (PFO) has yet to be reported. Here we report a case of embolic ischemic strokes in a young, avid cyclist with no prior known vascular risk factors. Read More

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The impact of medical insurance reimbursement on postoperative inflammation reaction in distinct cardiac surgery from a single center.

BMC Health Serv Res 2022 Apr 13;22(1):494. Epub 2022 Apr 13.

Department of Cardiac Surgery, Fuwai Hospital, National, Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Evidences shows that socioeconomic status is reversely associated with the risk of morbidity and mortality for people with cardiovascular disease via pro-inflammation mechanism, but the population profile is not deeply defined on. We aimed to investigate the impact of medical insurance coverage on postoperative systemic inflammatory reaction in two kinds of disease populations undergoing distinct cardiac procedures.

Methods: A total of 515 patients receiving open mitral valve procedure with high-total expense from May 2013 through May 2021 in Sichuan Provincial People's Hospital were retrospectively collected and stratified according to medical insurance reimbursement: low coverage with high out-pocket (< 30%), medium coverage (≤ 60%, but ≥ 30%), and high coverage (> 60%). Read More

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An Unusual Case of Hypoxia: A Case of Right-to-Left Interatrial Shunting in a Patient With a Patent Foramen Ovale and Normal Pulmonary Pressure.

Cureus 2022 Mar 9;14(3):e22998. Epub 2022 Mar 9.

Department of Internal Medicine, Grand Strand Regional Medical Center, Myrtle Beach, USA.

A patent foramen ovale (PFO) is an embryological remnant. Hypoxia in the setting of a PFO is generally attributed to pulmonary hypertension resulting in an increase in right atrial pressure and mixing of venous blood from the right atrium with blood in the left atrium resulting in a right-to-left interatrial shunt (RLIAS), thus deoxygenating it. We present a case of a 64-year-old male with a past medical history of coronary artery disease (CAD) who presented with two weeks of dyspnea on exertion and intermittent chest pressure. Read More

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