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    11149 results match your criteria Patent Ductus Arteriosus

    1 OF 223

    Interventional Closure of a Patent Ductus Arteriosus Using an Amplatz Canine Duct Occluder in an Alpaca Cria.
    J Vet Intern Med 2017 May 24. Epub 2017 May 24.
    College of Veterinary Medicine, The Ohio State University, Columbus, OH.
    A 6-month old female alpaca cria presented to The Ohio State University for evaluation of a cardiac murmur. Echocardiography revealed a left-to-right shunting patent ductus arteriosus, a restrictive left-to-right shunting perimembranous ventricular septal defect, and secondary moderate left atrial and ventricular dilation. Aortic root angiography demonstrated a type IIA patent ductus arteriosus (PDA). Read More

    [Periorbital pallor post application of mydriatic in infants with hydrocephalus associated to systemic effects].
    Rev Chil Pediatr 2017 Apr;88(2):280-284
    Unidad de Neonatología, Departamento de Pediatría, Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia.
    Adequate pupil dilation is needed to evaluate some neonates at risk of developing illness during this stage. However, this procedure is not free of adverse effects, either local or systemic. One of these complications is the local vasoconstriction of the preterm baby’s skin following the application of mydriatic eye drops. Read More

    [Digestive and Kidney Complications by indomethacin and ibuprofen in extreme preterm infants with patent ductus arteriosus].
    Rev Chil Pediatr 2017 Apr;88(2):243-251
    Servicio de Neonatología, Complejo Asistencial Barros Luco, Santiago, Chile.
    The symptomatic patent ductus arteriosus (sPDA) is common in extremely premature infants (EPI). In order to decrease the hemodynamic repercussion and avoid complications it is necessary to close it. Indomethacin or ibuprofen are used for this purpose with its associated risks. Read More

    Neonatologist-performed point-of-care functional echocardiography in the neonatal intensive care unit.
    Singapore Med J 2017 May;58(5):230-233
    Paediatric Cardiology Pte Ltd, Singapore.
    Functional echocardiography (fECHO) refers to a bedside, limited assessment of the ductus arteriosus, myocardial performance and pulmonary or systemic haemodynamics that is brief in nature and addresses a specific clinical question or management dilemma. This point-of-care ultrasonography is increasingly used internationally and locally among neonatal units to assist with management of neonatal haemodynamic conditions. This article intends to explain the modality, its indications, interpretation and implications for management, and how it impacts long-term outcomes, particularly in chronic lung disease for premature infants born before 32 weeks of gestation. Read More

    Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation.
    PLoS One 2017 22;12(5):e0175082. Epub 2017 May 22.
    Department of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
    Background: Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation.

    Aim: To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. Read More

    [A case of primary diagnosis of patent ductus arteriosus at the age of 75 years].
    Ter Arkh 2017 ;89(4):86-90
    A.L. Myasnikov Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow.
    The paper describes a case of primary diagnosis of functioning patent ductus arteriosus in a 75-year-old female patient. Read More

    Pregnancy Outcome of Abnormal Nuchal Translucency: A Systematic Review.
    J Clin Diagn Res 2017 Mar 1;11(3):QC12-QC16. Epub 2017 Mar 1.
    Faculty, Department of Radiology, Faculty of Para-Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
    Introduction: Nuchal Translucency (NT) is the sonographic form of subcutaneous gathering of liquid behind the foetal neck in the first trimester of pregnancy. There is association of increased NT with chromosomal and non-chromosomal abnormalities.

    Aim: The purpose of this systemic review was to review the pregnancy outcome of abnormal nuchal translucency. Read More

    [Congenital heart disease in adolescents and adults: Management in a general cardiology department in Senegal].
    Ann Cardiol Angeiol (Paris) 2017 May 12. Epub 2017 May 12.
    Service de cardiologie, hôpital général de Grand-Yoff, BP 3270, Dakar, Sénégal.
    Background: Congenital heart diseases in adults include malformations treated in childhood that decompensate secondarily and those asymptomatic at birth, appear later. This study aims to identify congenital heart diseases in adults in general cardiology department of Senegal and to assess clinical presentations, treatment and outcomes.

    Methods: We conducted a cross-sectional and descriptive study based on the records of patients aged at least 16 years and followed for congenital heart disease in the cardiology department of the General Hospital of Grand-Yoff in Dakar between May 2003 and March 2015. Read More

    Simultaneous transcatheter therapy for perimembranous ventricular septal defect combined with patent ductus arteriosus.
    J Card Surg 2017 May 11. Epub 2017 May 11.
    Department of Congenital Heart Disease, General Hospital of Shenyang Military Command, Shenyang, Liaoning, P. R. China.
    Objective: This study aims to assess the clinical efficiency and safety of simultaneous transcatheter interventional treatment for perimembranous ventricular septal defect (pmVSD) combined with patent ductus arteriosus (PDA).

    Methods: Twenty-five patients with pmVSD and PDA treated with simultaneous transcatheter interventions from April 2004 to December 2015 were included in this study. The mean age was 9. Read More

    Male child with somatic mosaic Osteopathia Striata with Cranial Sclerosis caused by a novel pathogenic AMER1 frameshift mutation.
    Am J Med Genet A 2017 May 12. Epub 2017 May 12.
    Department of Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    Osteopathia striata with cranial sclerosis (OSCS; OMIM #300373) is a rare X-linked dominant condition caused by mutations in the AMER1 gene (also known as WTX or FAM123B). It is a condition which usually affects females in whom the clinical phenotype can be extremely variable. Conversely affected males typically die in utero or during the neonatal period [Perdu et al. Read More

    Echocardiographic Assessment of Young Male Draft-Eligible Elite Hockey Players Invited to the Medical and Fitness Combine by the National Hockey League.
    Am J Cardiol 2017 Mar 29. Epub 2017 Mar 29.
    Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    The "athletic heart" is characterized by hypertrophy and dilation of the heart, in addition to functional and electrical remodeling. The aim of this study was to provide reference 2-dimensional (2DE) and 3-dimensional (3DE) echocardiographic measurements in a large database on draft-eligible elite ice hockey players and to determine the frequency of occult cardiac anomalies in this cohort of athletes. In this prospective cohort study, we performed a comprehensive cardiac assessment of the 100 top draft picks selected by the National Hockey League. Read More

    Bilateral microtia, canal atresia and aplasia of cochleovestibular nerve.
    Med J Malaysia 2017 Apr;72(2):135-137
    Universiti Kebangsaan Malaysia, Department of Radiology, Kuala Lumpur, Malaysia.
    A six-month-old baby with congenital patent ductus arteriosus (PDA), bilateral microtia and canal atresia was referred for hearing assessment. The audiology assessment revealed bilateral profound hearing loss, which is atypical for a case of pure canal atresia. Imaging was performed much earlier than usual and, as suspected, the patient also had bilateral severe inner ear anomaly. Read More

    Transcatheter closure of hemodynamic significant patent ductus arteriosus in 32 premature infants by amplatzer ductal occluder additional size-ADOIIAS.
    Catheter Cardiovasc Interv 2017 May 4. Epub 2017 May 4.
    NICU, Department of Pediatrics, American Memorial Hospital, Reims, France.
    Objectives: The advent of Amplatzer Duct Occluder II additional Size (ADOIIAS) provided the potential to close hemodynamic significant patent ductus arteriosus (HSPDA) and to analyze the feasibility, safety and efficacy of the device.

    Background: Treatment of a patent ductus arteriosus (PDA) in very premature neonates is still a dilemma for the neonatalogist who has to consider its significance and has to choose among different treatment options. Because surgical ligation and medical therapy both have their drawbacks, interventional catheterization might provide an alternative means of closing HSPDA. Read More

    Prevalence of Congenital Heart Disease among Infants from 2012 to 2014 in Langfang, China.
    Chin Med J (Engl) 2017 May;130(9):1069-1073
    Department of Ultrasound, PLA Army General Hospital, Beijing 100700, China.
    Background: Congenital heart disease (CHD) is the most common congenital malformations with high mortality and morbidity. The prevalence of CHD reported previously ranged from 4 per 1000 live births to 50 per 1000 live births. In this cross-sectional study, we aimed to document the prevalence of CHD in Langfang district of Hebei Province, China by analyzing data collected by hospitals located in 11 the counties of the district, as supported by a public health campaign. Read More

    Emergency laparotomy in infants born at <26 weeks gestation: a neonatal network-based cohort study of frequency, surgical pathology and outcomes.
    Arch Dis Child Fetal Neonatal Ed 2017 May 3. Epub 2017 May 3.
    Department of Paediatric Surgery and Urology, Southampton Children's Hospital, Southampton, UK.
    Objective: Identify the proportion of infants born at <26 completed weeks' gestation who require emergency laparotomy, and review the surgical pathology, incidence of subsequent surgical procedures and outcome.

    Design: Retrospective cohort review.

    Setting: Tertiary neonatal surgical unit. Read More

    Infective Endocarditis of the Left Main to Right Atrial Coronary Cameral Fistula.
    J Cardiovasc Echogr 2016 Oct-Dec;26(4):123-126
    Department of Cardiology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
    A 7-year-old female child presented with pyrexia of unknown origin. She had received an empirical regimen of antibiotic for possible endocarditis. Evaluation included multiple imaging supports and blood culture. Read More

    The role of serial measurements of serum insulin-like growth factor 1 levels in the development of retinopathy of prematurity.
    Turk Pediatri Ars 2017 Mar 1;52(1):10-14. Epub 2017 Mar 1.
    Department of Opthalmology, Uludağ University School of Medicine, Bursa, Turkey.
    Aim: To determine the role of serum insulin-like growth factor-1 levels in the development of retinopathy of prematurity, which is a major cause of childhood blindness worldwide.

    Material And Methods: We prospectively studied newborn infants born at a postmenstrual age of <32 weeks and birth weights <1 500 gr, between January 1(st), 2015, and December 31(st), 2015. A total of 40 infants were enrolled in the study. Read More

    [Multimodality imaging in the cardiac catheterization laboratory].
    Presse Med 2017 Apr 17. Epub 2017 Apr 17.
    M3C CHU de Nantes, hôpital G.-et-R.-Laënnec, l'institut du thorax, unité d'hémodynamique, fédération des cardiopathies congénitales, boulevard Jacques-Monod, 44093 Nantes cedex 1, France. Electronic address:
    Cardiac catheterization has greatly contributed to the progress made in the management of congenital heart diseases (CHD). Initially used in diagnosis, it allowed the understanding of heart diseases, their anatomy and hemodynamics. Gradually, the development of interventional cardiology has played a major role in the management of these malformations (Patent ductus arteriosus [PDA] and atrial septal defect [ASD] closure, pulmonary dilatation, percutaneous pulmonary valve implantation…). Read More

    Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study.
    PLoS One 2017 20;12(4):e0175065. Epub 2017 Apr 20.
    Department of Pediatric Cardiology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil.
    Objective: To report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome.

    Methods: An observational retrospective study was performed at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil. Read More

    Incidence and factors predisposing to retinopathy of prematurity in inborn infants less than 32 weeks of gestation.
    Hippokratia 2016 Apr-Jun;20(2):121-126
    Neonatal Department and Neonatal Intensive Care Unit (NICU), McGill University, Jewish General Hospital, Montreal, Quebec, Canada.
    Purpose: Retinopathy of prematurity (ROP) is a visual-impairing disorder of the developing retinal vasculature in premature infants. Recent advances in neonatal care have led to an increase in the vulnerable premature population. The aim of this retrospective study was to assess the incidence of ROP and its risk factors according to degree of prematurity. Read More

    Misses Opportunity: TOF Diagnoses in 4th Decade of Life.
    J La State Med Soc 2017 Mar-Apr;169(2):54. Epub 2017 Apr 15.
    Department of Internal Medicine, LSU Health, Baton Rouge, LA.
    Case: A 40 year old woman with a history of HIV, congestive heart failure secondary to an unknown congenital heart defect, and hypertension presented to our emergency department with worsening edema. On room air, oxygen saturation was 55 percent . On 5L of oxygen via nasal cannula, oxygen saturation was 88 percent . Read More

    Using benchmarking to identify inter-centre differences in persistent ductus arteriosus treatment: can we improve outcome?
    Cardiol Young 2017 Apr 12:1-9. Epub 2017 Apr 12.
    1Department of Neonatology,Máxima Medical Centre,Veldhoven,The Netherlands.
    Objective: The aim of this study was to identify inter-centre differences in persistent ductus arteriosus treatment and their related outcomes. Materials and methods We carried out a retrospective, multicentre study including infants between 24+0 and 27+6 weeks of gestation in the period between 2010 and 2011. In all centres, echocardiography was used as the standard procedure to diagnose a patent ductus arteriosus and to document ductal closure. Read More

    Prophylactic Indomethacin Compared with Delayed Conservative Management of the Patent Ductus Arteriosus in Extremely Preterm Infants: Effects on Neonatal Outcomes.
    J Pediatr 2017 Apr 7. Epub 2017 Apr 7.
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA. Electronic address:
    Objective: To determine whether prophylactic indomethacin (PINDO) has more or less morbidity than delayed conservative management of the moderate-to-large patent ductus arteriosus (PDA).

    Study Design: We performed a prospective double cohort controlled study of infants delivered at ≤27(6/7) weeks gestation (n = 397). From January 2005 through April 2011, all infants were treated with PINDO (n = 247). Read More

    Neurodevelopmental Outcomes of Preterm Infants Treated with Oral Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus.
    Am J Perinatol 2017 Apr 10. Epub 2017 Apr 10.
    Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
    Objective This study aims to determine the effects of paracetamol versus ibuprofen treatment given to preterm infants for the pharmacological closure of patent ductus arteriosus (PDA) on neurodevelopmental outcomes at 18 to 24 months' corrected age. Method A follow-up study was conducted to evaluate the neurodevelopmental outcomes of preterm infants (gestational age ≤ 30 weeks) enrolled in a randomized controlled trial comparing oral paracetamol versus oral ibuprofen for the closure of PDA. The developmental assessment was done by using "Bayley Scales of Infant Development, Second Edition" at 18 to 24 months' corrected age. Read More

    Prevalence and composition of CHD at different altitudes in Tibet: a cross-sectional study.
    Cardiol Young 2017 Apr 10:1-7. Epub 2017 Apr 10.
    Department of Cardiology,PLA Navy General Hospital,Beijing,People's Republic of China.
    Background: The prevalence of CHD has been well described worldwide except in Tibet. This study aimed to illustrate the prevalence and composition of CHD in Tibetan children according to altitude. Methods and results In the first part, we prospectively recruited 7088 unselected Tibetan children (4-17 years) from south-west Tibet. Read More

    Surgical management of postoperative ductal aneurysm: a case report.
    Cardiol Young 2017 Apr 10:1-3. Epub 2017 Apr 10.
    Department of Cardiovascular Surgery,Ibn Sina University Hospital,Rabat,Morocco.
    We report the case of 24-year-old woman who presented with ductal aneurysm 7 years after a triple ligation of a patent ductus arteriosus. She underwent successful repair through median sternotomy and under moderate hypothermic circulatory arrest and selective cerebral perfusion. Read More

    Factors associated with non-response to second course indomethacin for PDA treatment in preterm neonates.
    J Matern Fetal Neonatal Med 2017 May 2:1-5. Epub 2017 May 2.
    e Department of Pediatrics , Mount Sinai Hospital, University of Toronto , Toronto , Canada.
    Background: Failure of first course of indomethacin (FCI) for patent ductus arteriosus (PDA) treatment in preterm neonates often prompts clinicians to consider a second course (SCI).

    Objective: To identify factors including baseline characteristics and response to FCI that are associated with non-response to SCI for PDA treatment in preterm neonates.

    Methods: In this retrospective observational study, neonates ≤32 weeks admitted to a tertiary NICU over 5 years who received two indomethacin courses for PDA treatment were reviewed. Read More

    Neonatal repair of left atrial diverticulum with gigantic thrombus without cardiopulmonary bypass.
    Gen Thorac Cardiovasc Surg 2017 Apr 8. Epub 2017 Apr 8.
    Departments of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
    A 5-day-old neonate with coarctation of the aorta, hypoplastic aortic arch, large apical muscular ventricular septal defect, and patent ductus arteriosus developed pulmonary over-circulation and systemic hypoperfusion underwent bilateral pulmonary artery banding through median sternotomy as a part of hybrid stage I palliation. At operation, left atrial diverticulum with gigantic thrombus formation at the base of the left atrial appendage was incidentally detected by intraoperative direct echocardiography, and therefore, was successfully resected with the whole thrombus inside it without use of cardiopulmonary bypass. Histopathological finding was compatible with diverticulum. Read More

    Abiotrophia defectiva endarteritis with infective spondylodiscitis in an adult patient with patent ductus arteriosus.
    BMJ Case Rep 2017 Apr 7;2017. Epub 2017 Apr 7.
    Department of General Medicine, Christian Medical College and Hospital, Vellore, India.
    Endarteritis is a major complication in patients with patent ductus arteriosus, causing significant morbidity and mortality. We report an adult patient with asymptomatic patent ductus arteriosus and endarteritis involving the main pulmonary artery and secondary infective spondylodiscitis at the L5-S1 intervertebral disc caused by Abiotrophia defectivaA. defectiva, commonly referred to as nutritionally variant streptococci, cannot be identified easily by conventional blood culture techniques from clinical specimens. Read More

    Serial measures of cardiac performance using tissue Doppler imaging velocity in preterm infants <29weeks gestations.
    Early Hum Dev 2017 May 4;108:33-39. Epub 2017 Apr 4.
    Department of Cardiology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.
    Introduction: Tissue Doppler imaging (TDI) is a useful marker of myocardial performance in preterm infants. We aimed to demonstrate serial changes in TDI velocity in preterm infants <29weeks gestation, to assess the impact of inotropes and a haemodynamically significant patent ductus arteriosus (hsPDA).

    Methods: This was a prospective observational study of preterm infants <29weeks gestation. Read More

    Coarctation of the Aorta as a Complication of Surgical Ligation of Patent Ductus Arteriosus in a Premature Infant.
    Case Rep Pediatr 2017 13;2017:2647353. Epub 2017 Mar 13.
    Department of Pediatric Cardiology, University of Texas Medical Branch, Galveston, TX 77550, USA.
    Surgical ligation of a patent ductus arteriosus (PDA) is a commonly performed procedure. Complications are infrequent and most commonly include recurrent laryngeal nerve injury and rarely ligation of left pulmonary artery. We report a case of accidental ligation of the descending thoracic aorta leading to a clinically significant coarctation. Read More

    Mortality, rehospitalizations and costs in children undergoing a cardiac procedure in their first year of life in New South Wales, Australia.
    Int J Cardiol 2017 Mar 27. Epub 2017 Mar 27.
    Clinical and Population Perinatal Health Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Sydney Medical School Northern, University of Sydney, Sydney, NSW, Australia.
    Background: Cardiac procedures are part of management for many children with congenital heart disease (CHD). Using population health data, this study explores health outcomes of children undergoing a cardiac procedure in the first year of life to better understand the impact of CHD on children, families and health services.

    Methods And Results: A population-based record-linkage cohort study was undertaken. Read More

    Timing of surgical ligation and morbidities in very low birth weight infants.
    Medicine (Baltimore) 2017 Apr;96(14):e6557
    aDepartment of Pediatrics bDepartment of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    The present study examined whether early patent ductus arteriosus (PDA) surgical ligation at ≤2 weeks of life was associated with increased morbidities and mortality in very low birth weight infants (VLBWIs) who were diagnosed with hemodynamically significant (hs) PDA. Between December 2013 and December 2015, a total of 407 VLBWIs were admitted, of whom 145 (35.6%) infants were diagnosed with an hs PDA. Read More

    Tetralogy of Fallot Surgical Repair: Shunt Configurations, Ductus Arteriosus and the Circle of Willis.
    Cardiovasc Eng Technol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Mechanical Engineering, Koç University, Rumeli Feneri Kampüsü, Sarıyer, Istanbul, Turkey.
    In this study, hemodynamic performance of three novel shunt configurations that are considered for the surgical repair of tetralogy of Fallot (TOF) disease are investigated in detail. Clinical experience suggests that the shunt location, connecting angle, and its diameter can influence the post-operative physiology and the neurodevelopment of the neonatal patient. An experimentally validated second order computational fluid dynamics (CFD) solver and a parametric neonatal diseased great artery model that incorporates the ductus arteriosus (DA) and the full patient-specific circle of Willis (CoW) are employed. Read More

    TFAP2B mutation and dental anomalies.
    J Hum Genet 2017 Apr 6. Epub 2017 Apr 6.
    Center of Excellence in Medical Genetics Research, Chiang Mai University, Chiang Mai, Thailand.
    Mutations inTFAP2B has been reported in patients with isolated patent ductus arteriosus (PDA) and Char syndrome. We performed mutation analysis of TFAP2B in 43 patients with isolated PDA, 7 patients with PDA with other congenital heart defects and 286 patients with isolated tooth agenesis with or without other dental anomalies. The heterozygous c. Read More

    Diagnosis, imaging and clinical management of aortic coarctation.
    Heart 2017 Apr 4. Epub 2017 Apr 4.
    Department of Pediatric Cardiology, Wilhelmina Children's Hospital, The University of Utrecht, Utrecht, The Netherlands
    Coarctation of the aorta (CoA) is a well-known congenital heart disease (CHD), which is often associated with several other cardiac and vascular anomalies, such as bicuspid aortic valve (BAV), ventricular septal defect, patent ductus arteriosus and aortic arch hypoplasia. Despite echocardiographic screening, prenatal diagnosis of CoA remains difficult. Most patients with CoA present in infancy with absent, delayed or reduced femoral pulses, a supine arm-leg blood pressure gradient (>20 mm Hg), or a murmur due to rapid blood flow across the CoA or associated lesions (BAV). Read More

    Changing Management of the Patent Ductus Arteriosus: Effect on Neonatal Outcomes and Resource Utilization.
    Am J Perinatol 2017 Apr 4. Epub 2017 Apr 4.
    Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, California.
    Objective This historical cohort study investigated how a shift toward a more conservative approach of awaiting spontaneous closure of the patent ductus arteriosus (PDA) in preterm infants has affected neonatal outcomes and resource utilization. Methods We retrospectively studied very low birth weight infants diagnosed with a PDA by echocardiogram (ECHO) in 2006-2008 (era 1), when medical or surgical PDA management was emphasized, to those born in 2010-2012 (era 2) when conservative PDA management was encouraged. Multiple regression analyses adjusted for gestational age were performed to assess differences in clinical outcomes and resource utilization between eras. Read More

    Is the C242T Polymorphism of the CYBA Gene Linked with Oxidative Stress-Associated Complications of Prematurity?
    Antioxid Redox Signal 2017 May 8. Epub 2017 May 8.
    1 Department of Pediatrics, Maastricht University Medical Center (MUMC+) , School for Oncology and Developmental Biology (GROW), Maastricht, The Netherlands .
    The C242T polymorphism of CYBA (cytochrome B-245 alpha chain), the gene encoding the p22phox subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, has been linked to several conditions in which oxidative stress plays a pathogenic role. We investigated in a cohort of 451 preterm infants [gestational age (GA) ≤30 weeks] the association of the polymorphism with the risk of developing neonatal respiratory distress syndrome (RDS), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, patent ductus arteriosus, or intraventricular hemorrhage. We observed a significant association of the TT/CT genotype with RDS [odds ratio (OR) 2. Read More

    Clinical Characteristics of Adult Dogs More Than 5 Years of Age at Presentation for Patent Ductus Arteriosus.
    J Vet Intern Med 2017 May 3;31(3):685-690. Epub 2017 Apr 3.
    Department of Small Animal Clinical Sciences and the Michael E. DeBakey Institute for Comparative Cardiovascular Sciences and Biomedical Devices, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.
    Background: The median age at presentation for dogs with patent ductus arteriosus (PDA) is <6 months of age, and closure is associated with a decrease in heart size and increased survival time, which are not well described in older dogs.

    Objectives: To describe the clinical characteristics of dogs with PDA ≥5 years of age at the time of presentation to a veterinary referral hospital.

    Animals: 35 client-owned dogs. Read More

    Impact of advanced medical therapy for the outcome of an adult patient with Eisenmenger syndrome.
    Respir Med Case Rep 2017 9;21:16-20. Epub 2017 Mar 9.
    Department of Pulmonology and Immunology, Lithuanian University of Health Sciences, Eivenių 2, LT-50009, Kaunas, Lithuania.
    Eisenmenger syndrome (ES) is the most severe form of pulmonary arterial hypertension (PAH) associated with congenital heart disease. It is an extremely devastating condition with a serious impact on patients' life. Classical therapy of ES remains directed to avoid complications, such as erythrocytosis, treatment of congestive heart failure, prevention of infection, and secondary haematological abnormalities such as iron deficiency and coagulation disorders. Read More

    Construction of Ductal Diameter Centiles in the First 24 h of Life and Their Relation to Cerebral Blood Flow in Neonates Weighing Less Than 1250 g in the First 24 h of Life.
    J Trop Pediatr 2017 Mar 13. Epub 2017 Mar 13.
    Department of Neonatology, Fernandez Hospital, Hyderabad, Telangana 500029, India.
    Aims And Objectives: To evaluate the ductal diameter centiles in the first 24 h of life and their relation to cerebral blood flow in neonates weighing <1250 g in the first 24 h of life.

    Method And Material: This prospective observational cohort study enrolled 44 infants with birth weight <1250 g. Two-dimensional echocardiography and color Doppler were performed within the first 12 h of life and were repeated again in the next 12 h of life to assess the ductal size and middle cerebral artery (MCA) flows [peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV) and pulsatility index (PI)]. Read More

    Hypoplastic left heart syndrome: a novel surgical strategy for small-volume centres?
    Eur J Cardiothorac Surg 2017 May;51(5):1003-1008
    Department of Pediatric Cardiac Surgery, University Paris Descartes and Necker Sick Children Hospital, Paris, France.
    Objectives: We describe in a prospective study, a novel surgical technique for the management of hypoplastic left heart syndrome inspired by the hybrid Norwood approach.

    Methods: This new neonatal palliation comprises replacement of the patent ductus arteriosus (PDA) and aortic arch plasty with a pulmonary homograft associated with the banding of both pulmonary arteries and atrial septectomy, under cardiopulmonary bypass without aortic clamping and cardioplegia. Initial results led to tightening of the pulmonary artery band from 3. Read More

    Frequency of Development of Aortic Valve Disease in Unrepaired Perimembranous Ventricular Septal Defects.
    Am J Cardiol 2017 May 28;119(10):1670-1674. Epub 2017 Feb 28.
    Division of Pediatric Cardiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
    We sought to determine the natural history of aortic valve disease in patients with unrepaired perimembranous ventricular septal defects (pVSDs) and to identify echocardiographic parameters predictive of increased risk of surgical repair of pVSD because of aortic valve disease. We retrospectively analyzed all echocardiograms of patients with a diagnosis of pVSD at our institution from January 1999 to January 2015. All available echocardiographic data were collected. Read More

    Outcomes of Percutaneous Closure of Patent Ductus Arteriosus Accompanied With Unilateral Absence of Pulmonary Artery.
    Am J Med Sci 2017 Apr 1;353(4):389-393. Epub 2017 Feb 1.
    Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
    Background: Limited data have reported the outcomes of percutaneous closure of patent ductus arteriosus (PDA) in patients with unilateral absence of pulmonary artery (UAPA). This study aimed to evaluate the symptomatology, diagnosis and therapy, especially the transcatheter closure of PDA in patients with PDA associated with UAPA.

    Materials And Methods: Patients diagnosed with PDA and UAPA were retrospectively enrolled from August 2010 through January 2016. Read More

    Retinopathy of prematurity: Revisiting incidence and risk factors from Oman compared to other countries.
    Oman J Ophthalmol 2017 Jan-Apr;10(1):26-32
    Department of Pediatrics, Brookdale University Hospital, New York, USA.
    Purpose: The purpose of this study is to determine the incidence of retinopathy of prematurity (ROP) and the maternal/neonatal risk factors at a tertiary care hospital in Oman, compared to other countries.

    Patients And Methods: A retrospective analysis of premature neonates born with gestational age (GA) 24-32 weeks at Sultan Qaboos University Hospital, Oman, from January 2007 to December 2010. Maternal and neonatal in-hospital course was retrieved. Read More

    Evolution of hybrid interventions for congenital heart disease.
    Expert Rev Cardiovasc Ther 2017 Apr 23;15(4):257-266. Epub 2017 Mar 23.
    c Department of Cardiology , Our Lady's Children's Hospital, Crumlin , Dublin , Ireland.
    Introduction: Surgical and transcatheter interventions have seen a tremendous evolution in last three decades. Hybrid technology combines the achievements of both disciplines to bring substantial hemodynamic benefit to patients with congenital heart disease (CHD) in a minimally invasive manner. This collaboration between surgeons and interventionalists will continue to grow as the technology evolves to meet the demands of CHD patients, potentially avoiding cardiopulmonary bypass and vascular access complications as well as optimizing immediate technical outcomes with exit angiography. Read More

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