11,769 results match your criteria Patent Ductus Arteriosus


Patent ductus arteriosus and small for gestational age infants: Treatment approaches and outcomes.

Early Hum Dev 2019 Feb 13;131:10-14. Epub 2019 Feb 13.

Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: The current treatment approach in patent ductus arteriosus suggests the identification of high-risk infants that may benefit the most from treatment. Small for gestational age infants are a high-risk population in which the treatment approach to the patent ductus arteriosus and outcomes have not been described.

Aim: To compare the patent ductus arteriosus treatment approach and outcomes in small for gestational age and appropriate for gestational age infants. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.02.002DOI Listing
February 2019

A case report of interrupted aortic arch without patent ductus arteriosus and with double-outlet right ventricle.

Echocardiography 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, China.

A case of interruption of the aortic arch with double-outlet right ventricle is reported. Although the aortic arch was interrupted, there was no direct artery to supply blood to the descending aorta. However, a feeder vessel from the neck was found to be connected to the proximal descending aorta. Read More

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http://doi.wiley.com/10.1111/echo.14272
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http://dx.doi.org/10.1111/echo.14272DOI Listing
February 2019
1 Read

Natural evolution of ductus arteriosus with noninterventional conservative management in extremely preterm infants born at 23-28 weeks of gestation.

PLoS One 2019 13;14(2):e0212256. Epub 2019 Feb 13.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

This study aimed to determine the natural course of patent ductus arteriosus (PDA) with noninterventional conservative management and whether the presence and/or prolonged duration of hemodynamically significant (HS) PDA increased the risk of mortality and morbidities in extremely preterm (EPT) infants. We retrospectively reviewed the medical records of EPT infants born at 23-28 weeks of gestation (n = 195) from January 2011 to June 2014, when PDA was managed with noninterventional conservative treatment. We stratified infants into three subgroups of 23-24, 25-26, and 27-28 weeks and analyzed the prevalence and natural evolution of HS PDA, defined as ventilator dependency and PDA size ≥2 mm. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212256PLOS
February 2019

Early haemodynamically significant patent ductus arteriosus does not predict future persistence in extremely preterm infants.

Acta Paediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Women's and Children's Health, Uppsala University.

Aim: We assessed whether early haemodynamically significant patent ductus arteriosus (hsPDA) predicted persistent PDA in extremely preterm infants.

Methods: This prospective observational study of 60 infants born at 22-27 weeks of gestational age without any major congenital anomalies or heart defects was conducted at Uppsala University Children's Hospital from November 2012 to May 2015. Respiratory and systemic circulatory parameters were continuously recorded and echocardiographic examinations performed daily during the first three days of life. Read More

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http://dx.doi.org/10.1111/apa.14752DOI Listing
February 2019
1 Read

Urinary acute kidney injury biomarkers in very low-birth-weight infants on indomethacin for patent ductus arteriosus.

Pediatr Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany.

Background: Serum creatinine (SCr)- or urine output-based definitions of acute kidney injury (AKI) have important limitations in neonates. This study evaluates the diagnostic value of urinary biomarkers in very low-birth-weight (VLBW) infants receiving indomethacin for closure of a patent ductus arteriosus (PDA).

Methods: Prospective cohort study in 14 indomethacin-treated VLBW infants and 18 VLBW infants without indomethacin as controls. Read More

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http://dx.doi.org/10.1038/s41390-019-0332-9DOI Listing
February 2019
1 Read
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Does Postmenstrual Age Affect Medical Patent Ductus Arteriosus Treatment Success in Preterm Infants?

Am J Perinatol 2019 Feb 6. Epub 2019 Feb 6.

Section of Neonatology, Department of Pediatrics, Foothills Medical Centre, Cumming School of Medicine, University of Calgary, Alberta, Canada.

Introduction:  Patent ductus arteriosus (PDA) is the most common cardiovascular problem of prematurity. Our objective was to examine the effect of postmenstrual age (PMA) on response to medical PDA treatment.

Study Design:  This retrospective cohort study included infants ≤ 32 weeks' gestational age (GA) who received nonsteroidal anti-inflammatory drugs (NSAIDs) for PDA treatment. Read More

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http://dx.doi.org/10.1055/s-0039-1678555DOI Listing
February 2019
1 Read

Laron syndrome related to homozygous growth hormone receptor c.784>C mutation in a patient with hypoplastic pulmonary arteries.

Cardiovasc J Afr 2019 Jan 22;30:1-2. Epub 2019 Jan 22.

Department of Paediatric Endocrinology, Faculty of Medicine, Inonu University, Malatya, Turkey.

Laron syndrome, also known as growth hormone insensitivity, is an autosomal recessive disorder characterised by short stature due to mutations or deletions in the growth hormone receptor (GHR), leading to congenital insulin-like growth factor 1 (IGF1) deficiency. Cardiac abnormalities, such as patent ductus arteriosus or peripheral vascular disease are rare in patients with Laron syndrome, but cardiac hypertrophy has been observed after IGF1 therapy. In this report, we present a 10-year-and-5-month-old girl with severe peripheral-type pulmonary artery hypoplasia and Laron syndrome related to homozygous GHR c. Read More

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http://dx.doi.org/10.5830/CVJA-2019-002DOI Listing
January 2019
2 Reads

Understanding the Pathophysiology, Implications, and Treatment Options of Patent Ductus Arteriosus in the Neonatal Population.

Adv Neonatal Care 2019 Jan 31. Epub 2019 Jan 31.

Department of Graduate Nursing Science, East Carolina University, Greenville, North Carolina.

Background: Patent ductus arteriosus (PDA) is the persistence of a fetal shunt between the pulmonary artery and the aorta. This structure normally closes in the first 3 days after birth; however, closure is delayed in up to 80% of infants born at 25 to 28 weeks of gestation. Persistent PDA results in pulmonary overcirculation and systemic hypoperfusion. Read More

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http://dx.doi.org/10.1097/ANC.0000000000000590DOI Listing
January 2019
1 Read

Patent ductus arteriosus is associated with acute kidney injury in the preterm infant.

Pediatr Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatrics, Division of Pediatric Nephrology, New York Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, 10032, USA.

Background: This study aimed to test the hypothesis that a patent ductus arteriosus (PDA) is independently associated with acute kidney injury (AKI) in neonates ≤ 28 weeks gestation.

Methods: Preterm infants with echocardiographic diagnosis of moderate-large PDA at age ≤ 30 days were studied retrospectively. AKI, the primary outcome, was defined and staged according to serum creatinine using Kidney Disease Improving Global Outcomes (KDIGO) neonatal criteria. Read More

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http://dx.doi.org/10.1007/s00467-019-4194-5DOI Listing
January 2019

Successful Percutaneous Treatment of an Embolized Patent Ductus Arteriosus Occluder Device.

Vasc Endovascular Surg 2019 Jan 28:1538574418823384. Epub 2019 Jan 28.

2 Cardiology Department, Kartal Kosuyolu Heart Research and Training Hospital, Istanbul, Turkey.

Transcatheter closure has become the leading approach for closure of most instances of patent ductus arteriosus. However, there are some complications associated with this procedure. We report a case involving the embolization of a device in the right pulmonary artery during placement. Read More

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http://dx.doi.org/10.1177/1538574418823384DOI Listing
January 2019
1 Read

Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants.

Pediatr Crit Care Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Anesthesiology and Intensive Care, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.

Objectives: The postoperative course of patent ductus arteriosus ligation is often complicated by postligation cardiac syndrome, occurring in 10-45% of operated infants. Milrinone might prevent profound hemodynamic instability and improve the recovery of cardiac function in this setting. The present study aimed to describe the population pharmacokinetics of milrinone in premature neonates at risk of postligation cardiac syndrome and give dosing recommendations. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001879DOI Listing
January 2019
5 Reads

Absent Pulmonary Valve Syndrome in a Fetus: A Case Report and Literature Review.

Fetal Pediatr Pathol 2019 Jan 20:1-6. Epub 2019 Jan 20.

c Department of Medical Ultrasound , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.

Introduction: The main characteristics of absent pulmonary valve syndrome (APVS) include the absence or hypoplasia of the pulmonary valve, stenosis of the pulmonary valve annulus, and aneurysmal dilatation of the pulmonary trunk and its branches. In the more common type 1, the tetralogy of Fallot-like type, there is a ventricular septal defect, overriding aorta, pulmonary arterial dilatation, and absence of ductus arteriosus, The second type has an intact ventricular septum, less pulmonary artery dilatation, and a patent ductus arteriosus, with or without tricuspid atresia.

Case Report: This APVS had an intact ventricular septum with an absent ductus arteriosus. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2018.1
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http://dx.doi.org/10.1080/15513815.2018.1529066DOI Listing
January 2019
10 Reads

Intake of sucrose-sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in offspring: a Norwegian pregnancy cohort study.

Eur J Epidemiol 2019 Jan 19. Epub 2019 Jan 19.

Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.

Studies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened soft beverages during pregnancy and risk of CHD. Prospective cohort data with 88,514 pregnant women participating in the Norwegian Mother and Child Cohort Study was linked with information on infant CHD diagnoses from national health registers and the Cardiovascular Diseases in Norway Project. Read More

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http://link.springer.com/10.1007/s10654-019-00480-y
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http://dx.doi.org/10.1007/s10654-019-00480-yDOI Listing
January 2019
8 Reads

'Absent' pulmonary valve with intact ventricular septum mimicking tricuspid valve atresia: Prenatal diagnosis and postnatal course.

J Obstet Gynaecol Res 2019 Jan 17. Epub 2019 Jan 17.

Pediatric Cardiology, Tuscany Region-National Centre for Research Foundation, Ospedale del Cuore, Massa, Italy.

Absent pulmonary valve syndrome is a rare congenital heart disease characterized by absent or rudimentary pulmonary valve leaflets and hypoplastic pulmonary annulus. The most common variant, associated with tetralogy of Fallot, implies dilatation of pulmonary branches and usually absent ductus arteriosus. Rarely, absent pulmonary valve occurs with intact ventricular septum: pulmonary branches are normally sized or mildly dilated and ductus arteriosus is usually patent. Read More

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http://dx.doi.org/10.1111/jog.13878DOI Listing
January 2019
9 Reads

Wide Pulse Pressure Is Not Associated with Patent Ductus Arteriosus in the First Week of Life.

Am J Perinatol 2019 Jan 15. Epub 2019 Jan 15.

Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.

Background And Objectives:  Widened pulse pressure is generally associated with patent ductus arteriosus (PDA). Surprisingly, this is often not true for preterm infants during the first week of life when systolic and diastolic pressures are both reduced and pulse pressure may remain unchanged.

Methods:  This is a retrospective, observational review of individual blood pressure (BP) parameters preterm neonates <30 weeks' gestational age during the first week of life as correlated with ductal patency and severity. Read More

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http://dx.doi.org/10.1055/s-0038-1677475DOI Listing
January 2019
2 Reads

Low Renal Oxygen Saturation at Near-Infrared Spectroscopy on the First Day of Life Is Associated with Developing Acute Kidney Injury in Very Preterm Infants.

Neonatology 2019 Jan 15;115(3):198-204. Epub 2019 Jan 15.

Centre d'Etudes Périnatales de l'Océan Indien (EA 7388), CHU La Réunion, Site Sud, Saint Pierre,

Background: Acute kidney injury (AKI) is a frequent complication in preterm infants, and the identification of early markers of renal hypoperfusion is a chief challenge in neonatal intensive care units.

Objectives: To describe the association between early markers of cardiovascular function and renal perfusion with AKI occurrence in a cohort of preterm infants < 32 weeks' gestation.

Methods: 128 infants were prospectively included from birth to discharge. Read More

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http://dx.doi.org/10.1159/000494462DOI Listing
January 2019
2 Reads

Totally endoscopic ventricular septal defect repair using bilateral femoral arterial cannulation in an 8-year-old girl.

Int J Surg Case Rep 2019 Jan 9;55:4-6. Epub 2019 Jan 9.

Institute of Preventive Medicine and Public Health, Hanoi Medical University (HMU), Hanoi, Viet Nam.

Introduction: There are few reports on applying totally endoscopic surgery (TES) for repairing ventricular septal defect (VSD), especially in children.

Case Presentation: We described an 8-year-old girl, weighing 17 kg, who was diagnosed with peri-membranous VSD and patent ductus arteriosus (PDA). The patient had undergone trans-catheter PDA closure first, and 3 weeks later, TES was performed for VSD repair through 4 small trocars (one 12 mm trocar and three 5 mm trocars) without robotic assistance. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330555PMC
January 2019
1 Read

Complex pulmonary arteriovenous fistula in mother and daughter: Case report.

Medicine (Baltimore) 2019 Jan;98(2):e13922

Department of Cardiology, West China Hospital, Sichuan University, Chengdu.

Rationale: Complex pulmonary arteriovenous fistula (PAVF) is unusual, and even rarer in 2 members of a family. PAVF may not appear on chest X-ray or computed tomography imaging, especially in asymptomatic patients, and therapy is limited. Herein, PAVFs occurring in a mother and daughter are described, with the current standard methods of diagnosis and treatment of PAVF. Read More

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http://dx.doi.org/10.1097/MD.0000000000013922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336614PMC
January 2019
2 Reads

[Clinical characteristics and risk factors of very low birth weight and extremely low birth weight infants with bronchopulmonary dysplasia: multicenter retrospective analysis].

Authors:

Zhonghua Er Ke Za Zhi 2019 Jan;57(1):33-39

To analyze clinical characteristics and risk factors of very low birth weight and extremely low birth weight infants with bronchopulmonary dysplasia (BPD). A retrospective epidemiological study was performed in 768 neonates (376 males) with birth weights<1 500 g and gestational age ≤ 34 weeks who survived ≥28 days. Clinical data were obtained from the multi-center clinical database of neonatal intensive care units (NICU) in 19 hospitals of Jiangsu Province between January 1, 2017 and December 31, 2017. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.01.009DOI Listing
January 2019
2 Reads

Perinatal Risk Factors and Outcome Coding in Clinical and Administrative Databases.

Pediatrics 2019 Jan 9. Epub 2019 Jan 9.

Perinatal Epidemiology and Health Outcomes Research Unit, Divisions of Neonatology and.

Background And Objectives: Administrative databases may allow true population-based studies and quality improvement endeavors, but the accuracy of billing codes for capturing key risk factors and outcomes needs to be assessed. We sought to describe the performance of a statewide administrative database and the clinical database from the California Perinatal Quality Care Collaborative (CPQCC).

Methods: This population-based retrospective cohort study linked key perinatal risk factors and outcomes from the 133-unit CPQCC database to relevant billing codes from administrative maternal and newborn inpatient discharge records, for 50 631 infants born from 2006 to 2012. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361352PMC
January 2019
10 Reads

Acute Aortic Dissection as a Rare Complication of Percutaneous Closure Using the Amplatzer Vascular Plug II for a Tubular and Enlarged Patent Ductus Arteriosus in an Elderly Patient.

JACC Cardiovasc Interv 2019 Jan;12(1):e5-e7

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

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http://dx.doi.org/10.1016/j.jcin.2018.10.057DOI Listing
January 2019
2 Reads

Development of tissue Doppler-derived predictors of hemodynamically significant patent ductus arteriosus and the ability to incorporate it in targeted neonatal echocardiography protocol.

J Saudi Heart Assoc 2019 Apr 20;31(2):69-74. Epub 2018 Nov 20.

Neonatology Unit, Department of Pediatrics, Kasr AlAiny Faculty of Medicine, Cairo University, Cairo, EgyptEgypt.

Background: Hemodynamically significant (HS) patent ductus arteriosus (PDA) is a significant cause of mortality in preterm neonates. Early detection of HS PDA and pre-symptomatic closure may help in avoiding complications. For this to happen, easily performed predictors must be available; the aim of this paper is to test the reliability and repeatability of tissue Doppler-derived parameters for prediction of HS PDA. Read More

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http://dx.doi.org/10.1016/j.jsha.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313813PMC
April 2019
3 Reads

Hypoxia-induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA-ROCK-PTEN pathway.

J Cell Biochem 2018 Dec 28. Epub 2018 Dec 28.

Department of Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The Rho family plays crucial roles in O -induced vasoconstriction, cell proliferation, and migration. Rho GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein for the small GTPases of the Rho family. Our previous studies have demonstrated that ARHGAP26 expression was significantly downregulated in patent human ductus arteriosus (DA) tissue. Read More

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http://doi.wiley.com/10.1002/jcb.28294
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http://dx.doi.org/10.1002/jcb.28294DOI Listing
December 2018
3 Reads

Effects of protocol-based management on the post-operative outcome after systemic to pulmonary shunt.

Egypt Heart J 2018 Dec 28;70(4):271-278. Epub 2018 Oct 28.

King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Objectives: Systemic to pulmonary shunt (commonly known as Modified Blalock-Taussig shunt) is a palliative procedure in cyanotic heart diseases to overcome inadequate blood flow to the lungs. Based on the most recent risk stratification score, the mortality and morbidity of this procedure is still high especially in neonates and over-shunting patients. We developed and implemented protocol-based management in March 2013 to better standardize the management of these patients. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303540PMC
December 2018
1 Read

Aortic stiffness index and its association with cardiovascular functions in children before and after transcatheter closure of PDA.

Egypt Heart J 2018 Dec 28;70(4):261-266. Epub 2018 Sep 28.

Minia University, Cardiology Department, Egypt.

Background: Patent ductus arteriosus is generally associated with hyperdynamic status. Given the vascular shunt between the aorta and pulmonary artery, intrinsic aortic changes occur (aortic stiffness). In the present study, we attempted to assess the impact of PDA on aortic stiffness and its connection with cardiovascular function before and after transcatheter closure of PDA. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303348PMC
December 2018

Simultaneous Occurrence of Dysrhythmia and Seizure as a Diagnostic Difficulty; a Case Report.

Emerg (Tehran) 2018 8;6(1):e49. Epub 2018 Aug 8.

Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.

Torsades de pointes (TdP) is a rare but hazardous ventricular dysrhythmia caused by an increase in the QT interval of the heart rhythm and is categorized into congenital or acquired types. Signs and symptoms of TdP include syncope, seizure, ventricular fibrillation, and even sudden death. According to statistics, among these symptoms, syncope and the seizure can be considered as signs that make the TdP diagnosis difficult. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289149PMC
August 2018
4 Reads

Char Syndrome a novel mutation and new insights: A clinical report.

Eur J Med Genet 2018 Dec 21. Epub 2018 Dec 21.

Medical Genetics Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Lebanon; Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Lebanon. Electronic address:

Transcription Factor AP-2 Beta (TFAP2B) functions in the differentiation of neural crest cell derivatives and contributes to the embryogenesis of the ductus arteriosus. Mutations of TFAP2B produces Char syndrome. Char syndrome is an autosomal dominant disorder comprising facial dysmorphism, hand anomalies, and patent ductus arteriosus (PDA). Read More

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http://dx.doi.org/10.1016/j.ejmg.2018.12.012DOI Listing
December 2018

A comparison of postoperative outcomes with PDA ligation in the OR versus the NICU: a retrospective cohort study on the risks of transport.

BMC Anesthesiol 2018 Dec 22;18(1):199. Epub 2018 Dec 22.

Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, 757 Westwood Plaza, Suite 3325, Los Angeles, CA, 90095-7403, USA.

Background: Although patent ductus arteriosus (PDA) ligations in the Neonatal Intensive Care Unit (NICU) have been an accepted practice, many are still performed in the Operating Room (OR). Whether avoiding transport leads to improved perioperative outcomes is unclear. Here we aimed to determine whether PDA ligations in the NICU corresponded to higher risk of surgical site infection or mortality and if transport was associated with worsened perioperative outcomes. Read More

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https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12871-018-0658-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303951PMC
December 2018
10 Reads

Projected Future Cancer Risks in Children Treated With Fluoroscopy-Guided Cardiac Catheterization Procedures.

Circ Cardiovasc Interv 2018 Nov;11(11):e006765

Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.).

Background Children treated with cardiac catheterization procedures have now a long life expectancy and consequently potential long-term radiation-induced risks. We projected lifetime attributable risks (LARs) of cancer incidence from the most frequent procedures in pediatrics: atrial septal defect closure, patent ductus arteriosus occlusion, or pulmonary valvuloplasty. Methods and Results Organ equivalent doses were estimated for 1251 procedures performed in children aged ≤15 years at 2 reference catheterization centers in France from 2009 to 2013. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006765DOI Listing
November 2018
2 Reads

SOFT syndrome in a patient from Chile.

Am J Med Genet A 2019 Mar 20;179(3):338-340. Epub 2018 Dec 20.

Department of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

SOFT syndrome (MIM614813) is an extremely rare primordial dwarfism caused by biallelic mutations in the POC1A gene. It is characterized by prenatal short stature, onychodysplasia, facial dysmorphism, hypotrichosis, and variable skeletal abnormalities including hypoplastic pelvis and sacrum, small hands, and cone-shaped epiphyses, as well as delayed bone age. To the best of our knowledge, only eight POC1A mutations have been reported in humans to date. Read More

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http://doi.wiley.com/10.1002/ajmg.a.61015
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http://dx.doi.org/10.1002/ajmg.a.61015DOI Listing
March 2019
7 Reads

Comparison of efficacy of paracetamol and ibuprofen in preterm infants.

J Matern Fetal Neonatal Med 2018 Dec 18:1-41. Epub 2018 Dec 18.

b Department of Radiodiagnosis , All India Institute of Medical Sciences , Jodhpur , India.

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http://dx.doi.org/10.1080/14767058.2018.1559289DOI Listing
December 2018
3 Reads

Use of acetaminophen for patent ductus arteriosus treatment: a single center experience.

J Matern Fetal Neonatal Med 2019 Jan 28:1-7. Epub 2019 Jan 28.

a Department of Pediatrics, Division of Newborn Medicine , University of Massachusetts Medical School- Baystate , Springfield , MA , USA.

Purpose: Patent ductus arteriosus (PDA) continues to be one of the most common complications associated with preterm birth. Up to 70% of infants born before 28 weeks gestational age may require some form of medical or surgical treatment for PDA closure. Recent studies have suggested acetaminophen to be a promising new alternative to indomethacin and ibuprofen for closure of PDA with potentially fewer adverse effects. Read More

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http://dx.doi.org/10.1080/14767058.2018.1559810DOI Listing
January 2019
1 Read

Neonatal Death Caused by Interrupted Aortic Arch Associated With 22q11.2 Deletion Syndrome: An Autopsy Case Report.

Am J Forensic Med Pathol 2018 Dec 17. Epub 2018 Dec 17.

Division of Genomic Medicine, Kanazawa Medical University, Ishikawa, Japan.

A case of clinically unsuspected fatal interrupted aortic arch (IAA) is described. A 17-day-old Japanese girl unexpectedly entered respiratory arrest at home. On autopsy, the heart was hypertrophic, with no apparent connection between the ascending and descending aortas. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000454DOI Listing
December 2018
3 Reads

Assessment of hemodynamic parameters in the assessment of a patent ductus arteriosus: It is still a puzzle.

J Pediatr 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatric Cardiology Saarland University Medical Center Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jpeds.2018.11.049DOI Listing
December 2018
1 Read

What is the Most Efficacious Pharmacological Therapy for Patent Ductus Arteriosus Closure in Premature Infants?

Ir Med J 2018 Oct 11;111(9):816. Epub 2018 Oct 11.

Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.

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October 2018

Anatomy, baseline characteristics, and procedural outcome of patent ductus arteriosus in German Shepherd dogs.

J Vet Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: German Shepherd dogs (GSD) are predisposed to developing patent ductus arteriosus (PDA) and are reportedly prone to type III (tubular) PDA anatomy. Dogs with type III anatomy are not considered favorable candidates for device-based intervention.

Objective: To describe the PDA anatomy, baseline characteristics, and procedural outcome of GSD with PDA. Read More

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http://dx.doi.org/10.1111/jvim.15401DOI Listing
December 2018
1 Read

Unwinding old habits: deimplementation of treatment regimens for patent ductus arteriosus in preterm infants.

Authors:
William E Benitz

J Pediatr (Rio J) 2018 Dec 11. Epub 2018 Dec 11.

Stanford University School of Medicine, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Palo Alto, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jped.2018.12.003DOI Listing
December 2018
1 Read

What is a hemodynamically significant PDA in preterm infants?

Congenit Heart Dis 2018 Dec 12. Epub 2018 Dec 12.

Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.

Objective: There is no consensus on the definition of a hemodynamically significant patent ductus arteriosus (hsPDA). In this review article, our objective is to discuss the main variables that one should consider when determining the hemodynamic significance of a PDA.

Results: We describe the various approaches that have been utilized over time to define an hsPDA and discuss the strengths and weaknesses of each echocardiographic index. Read More

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http://dx.doi.org/10.1111/chd.12727DOI Listing
December 2018
1 Read

Late onset neonatal acute kidney injury: results from the AWAKEN Study.

Pediatr Res 2019 Feb 13;85(3):339-348. Epub 2018 Dec 13.

Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY, USA.

Background: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d).

Methods: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Read More

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http://www.nature.com/articles/s41390-018-0255-x
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http://dx.doi.org/10.1038/s41390-018-0255-xDOI Listing
February 2019
7 Reads

Thoracic endovascular repair technique for the treatment of patent ductus arteriosus in an elderly patient: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13558

Department of Thoracic and Cardiovascular surgery, College of Medicine, Yeungnam University, Daegu, Korea.

Rationale: Patent ductus arteriosus (PDA) ligation by open surgery is more difficult and dangerous in elderly patients than in infants. Nowadays, simple and safe interventional catheterization technology is used for the closure of uncomplicated isolated PDAs. Therefore, an alternative less invasive therapeutic option must be developed to treat complicated PDA. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812070-0010
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http://dx.doi.org/10.1097/MD.0000000000013558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310524PMC
December 2018
6 Reads

Reducing Radiation Exposure in Cardiac Catheterizations for Congenital Heart Disease.

Pediatr Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Pediatric Cardiology, Yale School of Medicine, 333 Cedar St, LLCI 302, New Haven, CT, 06510, USA.

Ionizing radiation exposure is a necessary risk entailed during congenital cardiac catheterizations. The congenital catheterization lab at Yale New Haven Children's Hospital employed quality improvement strategies to minimize radiation exposure in this vulnerable population. In two phases, we implemented six interventions, which included adding and utilizing lower fluoroscopy and digital angiography (DA) doses, increasing staff and physician radiation awareness, focusing on tighter collimation, and changing the default fluoroscopy and DA doses to lower settings. Read More

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http://dx.doi.org/10.1007/s00246-018-2039-9DOI Listing
December 2018
1 Read

Simultaneous operative repair of pectus excavatum and concurrent congenital heart defects.

Interact Cardiovasc Thorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiothoracic Surgery, Hunan Children's Hospital, Changsha, China.

Objectives: The aim of this study is to describe an effective surgical strategy for the treatment of children with pectus excavatum (PE) and concurrent congenital heart defect (CHD).

Methods: We retrospectively reviewed the medical records of all children (n = 16) who underwent simultaneous repair of PE with concurrent CHD at the Hunan Children's Hospital from July 2007 to December 2017. Among them, 7 patients had a simple atrial septal defect (ASD); 4 patients had a simple ventricular septal defect (VSD); 3 patients had both VSD and ASD; 1 patient had VSD, ASD and patent ductus arteriosus; and 1 patient had VSD complicated by pulmonary hypertension. Read More

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https://academic.oup.com/icvts/advance-article/doi/10.1093/i
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http://dx.doi.org/10.1093/icvts/ivy294DOI Listing
December 2018
14 Reads

Pharmacotherapy for patent ductus arteriosus closure.

Authors:
John M Ferguson

Congenit Heart Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Read More

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http://dx.doi.org/10.1111/chd.12715DOI Listing
December 2018
4 Reads

State of the art-Patent ductus arteriosus.

Authors:

Congenit Heart Dis 2018 Sep;13(5):645

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https://onlinelibrary.wiley.com/doi/abs/10.1111/chd.12689
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http://dx.doi.org/10.1111/chd.12689DOI Listing
September 2018
10 Reads

Genetic variants associated with patent ductus arteriosus in extremely preterm infants.

J Perinatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Objective: Patent ductus arteriosus (PDA) is a commonly observed condition in preterm infants. Prior studies have suggested a role for genetics in determining spontaneous ductal closure. Using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with PDA in extremely preterm infants. Read More

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http://dx.doi.org/10.1038/s41372-018-0285-6DOI Listing
December 2018
3 Reads

Survey of preterm neuro-centric care practices in California neonatal intensive care units.

J Perinatol 2019 Feb 5;39(2):256-262. Epub 2018 Dec 5.

Department of Pediatrics, Division of Neonatal & Developmental Medicine, Stanford University, Stanford, CA, USA.

Objective: Examine the adoption and presence of preterm, neuro-centric care practices across neonatal intensive care units (NICUs).

Study Design: Statewide, cross-sectional survey of California NICUs. Data were collected surrounding the timing of adoption and presence of delivery room practices, nursing protocols, provider management practices and quality improvement initiatives. Read More

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http://dx.doi.org/10.1038/s41372-018-0283-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351217PMC
February 2019
1 Read

Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants.

Pediatrics 2019 Jan 5;143(1). Epub 2018 Dec 5.

Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background: Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes in preterm infants.

Methods: Infants of <29 weeks' gestation born between April 2009 and September 2011 and admitted to Canadian Neonatal Network units and then assessed at Canadian Neonatal Follow-up Network centers were studied. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1348DOI Listing
January 2019
38 Reads

Simultaneously surgical management of adult complex coarctation of aorta concomitant with intracardiac abnormality.

J Thorac Dis 2018 Oct;10(10):5842-5849

Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: To explore surgical management of complex coarctation of aorta (COA) concomitant with intracardiac abnormality, in order to provide recommendations for safe and reliable treatment.

Methods: Totally, six adult cases demonstrating complex COA concomitant with intracardiac abnormality were reviewed from our department between May 2012 and June 2017. Four patients were male and two patients were female, the age range being 43. Read More

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http://dx.doi.org/10.21037/jtd.2018.09.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236160PMC
October 2018
7 Reads