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    Cardiac remodeling in preterm infants with prolonged exposure to a patent ductus arteriosus.
    Congenit Heart Dis 2017 Feb 22. Epub 2017 Feb 22.
    Department of Cardiology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia.
    Background: Sustained volume load due to a patent ductus arteriosus (PDA) leads to cardiac remodeling. Remodeling changes can become pathological and are associated with cardiovascular disease progression. Data on remodeling changes in preterm infants is not available. Read More

    Multicenter Off-Label Use of Nit-Occlud Coil in Retrograde Closure of Small Patent Ductus Arteriosus.
    Pediatr Cardiol 2017 Feb 21. Epub 2017 Feb 21.
    Pediatric Cardiology Department, Cairo University Children's Hospital, Cairo University, 2 Aly Basha Ibrahim Street, Mounira, PO Box: 11111, Cairo, Egypt.
    We studied the safety and efficacy of closing patent ductus arteriosus by Nit-Occlud coils via retrograde approach. This is a retrospective study of 46 attempts to close ducts by this method in two hospitals in Egypt and Iran. Ductus arteriosus was crossed by left or right Judkins or endhole catheters. Read More

    Use of Model-based Iterative Reconstruction to Improve Detection of Congenital Cardiovascular Anomalies in Infants Undergoing Free-breathing Computed Tomographic Angiography.
    J Thorac Imaging 2017 Mar;32(2):127-135
    *Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD †Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.
    Purpose: The aim of the study was to assess the detection of congenital cardiovascular anomalies (congenital heart disease) in neonates and infants using model-based iterative reconstruction (MBIR) algorithm compared with hybrid iterative reconstruction (HIR) and filtered back projection (FBP) reconstructions on axial computed tomography (CT) performed at minimum scanner dose.

    Materials And Methods: Over 1 year, all CT angiographies performed in infants below 3 months of age with congenital heart disease were assessed retrospectively. All were scanned on a 256-slice CT (Brilliance iCT) using single axial rotation at minimum allowable scanner dose (80 kV/10 mAs), with patients free-breathing. Read More

    The Medtronic Micro Vascular Plug™ for Vascular Embolization in Children With Congenital Heart Diseases.
    J Interv Cardiol 2017 Feb 16. Epub 2017 Feb 16.
    The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
    Objectives: To describe the early multi-center, clinical experience with the Medtronic Micro Vascular Plug™ (MVP) in children with congenital heart disease (CHD) undergoing vascular embolization.

    Background: The MVP is a large diameter vascular occlusion device that can be delivered through a microcatheter for embolization of abnormal blood vessels.

    Methods: A retrospective review of embolization procedures using the MVP in children with CHD was performed in 3-centers. Read More

    Isolated Hypoplasia of Left Pulmonary Artery with Agenesis of Left Lobe of Thyroid: A Case Report.
    J Clin Diagn Res 2016 Dec 1;10(12):SD04-SD05. Epub 2016 Dec 1.
    Professor and Head, Department of Cardiology, Chettinad Hospital and Research Institute , Chennai, Tamil Nadu, India .
    Isolated Unilateral hypoplasia or agenesis of a branch of pulmonary artery is very rare. It is usually seen associated with congenital heart diseases such as tetralogy of Fallot, atrial septal defect, coarctation of the aorta, right aortic arch, truncus arteriosus, patent ductus arteriosus and pulmonary atresia. It occurs as a result of lack of embryological development of either the left or right sixth aortic arch and has been found to present itself with various clinical manifestations as during childhood it presents as contralateral pulmonary hypertension and in adults as haemoptysis. Read More

    Patent ductus arteriosus in premature infants: to treat or not to treat?
    J Perinatol 2017 Feb 16. Epub 2017 Feb 16.
    Division of Newborn Services, The George Washington University Hospital, Washington, DC, USA.
    Objective: Closing patent ductus arteriosus (PDA) is a widely accepted approach in the management of very low birth weight (VLBW) infants. Our objective is to test the hypothesis that conservative management (no treatment) of PDA will not affect survival without chronic lung diseases (CLD).

    Study Design: This retrospective study utilizes a prospectively collected database to compare two cohorts of VLBW infants. Read More

    Comparison of the Efficacy of Three Natural Surfactants (Curosurf, Survanta, and Alveofact) in the Treatment of Respiratory Distress Syndrome Among Neonates: A Randomized Controlled Trial.
    Iran J Pediatr 2016 Oct 25;26(5):e5743. Epub 2016 Jul 25.
    Department of Social Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran.
    Background: Although several different types of natural surfactants are available, including Alveofact, Curosurf, and Survanta, the preferred type and the magnitude of their effects are unknown.

    Objectives: This study was designed to compare the effects of these three surfactants on the gas exchange and clinical outcomes of neonates with respiratory distress syndrome (RDS).

    Methods: This triple-blind randomized clinical trial studied all preterm neonates ≤ 37 weeks with RDS who were admitted to the neonatal intensive care unit (NICU) of Taleghani hospital (Tabriz, Iran) between 2012 and 2013. Read More

    Radiation dose benchmarks in pediatric cardiac catheterization: A prospective multi-center C3PO-QI study.
    Catheter Cardiovasc Interv 2017 Feb 15. Epub 2017 Feb 15.
    Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
    Objectives: This study sought to update benchmark values to use a quality measure prospectively.

    Background: Congenital Cardiac Catheterization Outcomes Project - Quality Improvement (C3PO-QI), a multi-center registry, defined initial radiation dose benchmarks retrospectively across common interventional procedures. These data facilitated a dose metric endorsed by the American College of Cardiology in 2014. Read More

    Patent Ductus Arteriosus With Eisenmenger Syndrome: Difficult Diagnosis Made Easily With Saline Contrast Echocardiography.
    Cardiol Res 2016 Jun 24;7(3):117-118. Epub 2016 Jun 24.
    LPS Institute of Cardiology, GSVM Medical College, Kanpur, India.
    The diagnosis of patent ductus arteriosus (PDA) with Eisenmenger syndrome is difficult. We report a case of 35-year-old male who came to our outpatient department (OPD) for evaluation of repeated hemoptysis and dyspnea on exertion. He had already completed two courses of ATT. Read More

    Pentoxifylline Treatment of Very Low Birth Weight Neonates with Nosocomial Sepsis.
    Am J Perinatol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Pediatrics, Bagcılar Training and Research Hospital, Istanbul, Turkey.
    Objective The objective of this study was to assess the result of intravenous pentoxifylline as an adjunct to antibiotic therapy on mortality and morbidity in very low birth weight (VLBW) preterm neonates with nosocomial sepsis. Methods For the 18 VLBW preterm neonates, as an adjunct therapy to antibiotics regimens, pentoxifylline (5 mg/kg/h for 6 hours) was administered to premature infants with sepsis on 3 successive days. Clinical and laboratory parameters were recorded before and after treatment. Read More

    Eisenmenger Syndrome and Pregnancy: Novel ECMO configuration as a Bridge to Delivery and Recovery Utilizing a Multidisciplinary Team.
    ASAIO J 2017 Feb 9. Epub 2017 Feb 9.
    1Department of Pediatrics, Columbia University Medical Center 2Department of Medicine, Columbia University Medical Center 3Department of Surgery, Columbia University Medical Center 4Department of Obstetrics and Gynecology, Columbia University Medical Center.
    Pregnancy is typically contraindicated in Eisenmenger syndrome because of its association with excessively high maternal and fetal morbidity and mortality. We report on our novel approach to successfully managing a 29 year-old pregnant woman with an unrepaired patent ductus arteriosus (PDA) with Eisenmenger syndrome through delivery and recovery. Venovenous ECMO was utilized during induction of labor to stabilize maternal hemodynamics and optimize fetal oxygenation by creating an oxygenated right-to-left shunt through the PDA. Read More

    Isolated left brachiocephalic artery with the right aortic arch: A rare differential of large patent ductus arteriosus.
    Ann Pediatr Cardiol 2017 Jan-Apr;10(1):78-81
    Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
    We report a case of isolation of the left brachiocephalic artery with the right aortic arch in a 9-year-old male child masquerading as large patent ductus arteriosus with left-to-right shunt. We have emphasized the subtle clinical findings which served as clues to the diagnosis. Read More

    [Ebstein's anomaly revealed by fetal-placental anasarca. Original case study].
    Pan Afr Med J 2016 28;24:279. Epub 2016 Jul 28.
    Equipe de Recherche en Santé et Nutrition du Couple Mère Enfant, Service de Médecine et de Réanimation Néonatale à l'Hôpital d'Enfant de Rabat, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
    Ebstein's anomaly is a congenital heart defect rarely revealed by fetal-placental anasarca. Our study reports an original case of Ebstein's anomaly diagnosed during fetal-placental anasarca assessment, revealed by antenatal ultrasound, objectifying hydramnios, ascites and pericardial effusion. Echocardiography allowed the identification of Ebstein's disease with significant tricuspid insufficiency, mitral regurgitation (grade 3) and patent ductus arteriosus. Read More

    Transcatheter Closure of Patent Ductus Arteriosus in Adolescents and Adults: A Case Series.
    Acta Med Indones 2016 Oct;48(4):314-319
    Department of Pediatrics, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
    During 11 years period from January 2005 to December 2015 there were 18 adolescent and adult patients  who underwent transcatheter closure of PDA using PDA Amplatzer Duct Occluder (ADO). There were 9 cases with age of 14 to 18 years and 9 cases with age of more than 18 years where the oldest case was 46 years old. Two cases were male and 16 cases were female. Read More

    Normative Values of Aortic Arch Structures in Premature Infants.
    J Am Soc Echocardiogr 2017 Jan 27. Epub 2017 Jan 27.
    Department of Pediatric Cardiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: Aortic arch abnormalities represent 5% to 8% of all congenital heart disease. Measurements of the aortic arch dimensions on two-dimensional echocardiographic images remain of critical importance in the diagnosis of aortic arch pathology. To define aortic hypoplasia or coarctation, measured dimensions must be compared with normal values. Read More

    Patent Ductus Arteriosus Treatment in Very Preterm Infants: A European Population-Based Cohort Study (EPICE) on Variation and Outcomes.
    Neonatology 2017 Jan 26;111(4):367-375. Epub 2017 Jan 26.
    Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
    Background: Spontaneous closure of patent ductus arteriosus (PDA) occurs frequently in very preterm infants and despite the lack of evidence for treatment benefits, treatment for PDA is common in neonatal medicine.

    Objectives: The aim of this work was to study regional variations in PDA treatment in very preterm infants (≤31 weeks of gestation), its relation to differences in perinatal characteristics, and associations with bronchopulmonary dysplasia (BPD) and survival without major neonatal morbidity.

    Methods: This was a population-based cohort study in 19 regions in 11 European countries conducted during 2011 and 2012. Read More

    Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age.
    PLoS One 2017 26;12(1):e0170797. Epub 2017 Jan 26.
    Department of Neonatology, Maternité Régionale, CHRU NANCY, France.
    Conventional magnetic resonance imaging (MRI) at term equivalent age (TEA) is suggested to be a reliable tool to predict the outcome of very premature infants. The objective of this study was to determine simple reproducible MRI indices, in premature infants and to analyze their neonatal determinants at TEA. A cohort of infants born before 32 weeks gestational age (GA) underwent a MRI at TEA in our center. Read More

    A Comparison of Early Ibuprofen and Indomethacin Administration to Prevent Intraventricular Hemorrhage Among Preterm Infants.
    Acta Med Iran 2016 Dec;54(12):788-792
    Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
    Intraventricularhemorrhage (IVH) is one of thecommon morbidities among preterm neonates. In thepresentstudy, we set out to evaluate the efficacy of two prophylactic modalities (ibuprofen and indomethacin prophylaxis) for prevention of IVH in our local setting. A prospective study was carried out in Akbar-Abadi Hospital, Tehran-Iran (2013-2014). Read More

    Post-transitional adaptation of the left heart in uncomplicated, very preterm infants.
    Cardiol Young 2017 Jan 24:1-7. Epub 2017 Jan 24.
    2University of Newcastle,Newcastle,New South Wales,Australia.
    Background: The postnatal period in preterm infants involves multiple physiological changes occurring immediately after birth and continuing for days or weeks. To recognise and treat compromise, it is important to measure cardiovascular function. The aim of this study was to describe longitudinal left ventricular function using conventional and novel echocardiography techniques in preterm infants who did not experience significant antenatal or postnatal complications and treatments. Read More

    Deletion of 2.7 kb near HOXD3 in an Arabian horse with occipitoatlantoaxial malformation.
    Anim Genet 2017 Jan 23. Epub 2017 Jan 23.
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
    In the horse, the term occipitoatlantoaxial malformation (OAAM) is used to describe a developmental defect in which the first cervical vertebra (atlas) resembles the base of the skull (occiput) and the second cervical vertebra (axis) resembles the atlas. Affected individuals demonstrate an abnormal posture and varying degrees of ataxia. The homeobox (HOX) gene cluster is involved in the development of both the axial and appendicular skeleton. Read More

    Double-outlet right ventricle with an intact interventricular septum and concurrent hypoplastic left ventricle in a calf.
    J Vet Cardiol 2017 Jan 19. Epub 2017 Jan 19.
    Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
    A 3-day-old Hereford heifer calf presented for evaluation of lethargy and dyspnea, with persistent hypoxia despite supplemental oxygen therapy. A grade III/VI right apical systolic murmur was noted during cardiac auscultation. Echocardiography revealed a double-outlet right ventricle with an intact interventricular septum and concurrent hypoplastic left ventricle and tricuspid valve dysplasia. Read More

    Prevalence and independent risk factors for hearing impairment among very low birth weight infants.
    Int J Pediatr Otorhinolaryngol 2017 Feb 27;93:123-127. Epub 2016 Dec 27.
    Division of Neonatology, Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, 33305, Taiwan.
    Background: Although we've made big strides in perinatal and neonatal care, auditory handicap remains a serious complication in those who were born very premature.

    Objectives: The aim was to determine the prevalence and analyze possible risk factors of hearing impairment in very-low-birth-weight (VLBW) infants.

    Materials And Methods: This was a retrospective study by reviewing medical records of all VLBW infants (BW ≤ 1500 g) admitted to NICU of Chang Gung Children's Hospital over 2 years period from Jan. Read More

    Enhanced EP4 Expression in a Pulmonary Artery Aneurysm With Dissection in a Patient With Pulmonary Arterial Hypertension.
    Circ Cardiovasc Imaging 2017 Feb;10(2)
    From the Department of Cardiovascular Medicine (S.A., K.N., T.S., K.E., H.I.) and Department of Cardiovascular Surgery (S.K.), Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan; and Department of Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan (U.Y.).

    Vocal fold paralysis in preterm infants: prevalence and analysis of risk factors.
    J Perinatol 2017 Jan 19. Epub 2017 Jan 19.
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
    Objective: To calculate the prevalence of vocal fold paralysis (VFP) in preterm (<37 weeks of gestation) infants at a single neonatal intensive care unit (NICU) and identify risk factors for the development of VFP.

    Study Design: This is a case control study of all surviving preterm infants admitted to the NICU at Children's Hospital of Wisconsin from 2006 to 2012, comparing those with and without VFP. Multivariate analysis was performed to identify significant risk factors for VFP. Read More

    [High-risk factors and clinical characteristics of massive pulmonary hemorrhage in infants with extremely low birth weight].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Jan;19(1):54-58
    Department of Neonatology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
    Objective: To explore the high-risk factors and analyze the clinical characteristics of massive pulmonary hemorrhage (MPH) in infants with extremely low birth weight (ELBW).

    Methods: Two hundred and eleven ELBW infants were included in this study. Thirty-five ELBW infants who were diagnosed with MPH were labelled as the MPH group, and 176 ELBW infants without pulmonary hemorrhage were labelled as the control group. Read More

    Relationship Between Perfusion Index And Patent Ductus Arteriosus In Preterm Infants.
    Pediatr Res 2017 Jan 18. Epub 2017 Jan 18.
    Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States.
    Background: Perfusion index (PI) is a noninvasive measure of perfusion. ΔPI (difference between pre and post-ductal PI) may identify hemodynamically significant PDA. However, studies are limited to brief and intermittent ΔPI sampling. Read More

    A retrospective analysis of a pediatric tele-echocardiography service to treat, triage, and reduce trans-Pacific transport.
    J Telemed Telecare 2017 Jan 1:1357633X16689500. Epub 2017 Jan 1.
    5 Tripler Army Medical Center, Department of Pediatrics, Hawaii, USA.
    Introduction Tele-echocardiography can ensure prompt diagnosis and prevent the unnecessary transport of infants without critical congenital heart disease, particularly at isolated locations lacking access to tertiary care medical centers. Methods We retrospectively reviewed all infants who underwent tele-echocardiography at a remote 16-bed level IIIB NICU from June 2005 to March 2014. Tele-echocardiograms were completed by cardiac sonographers in Okinawa, Japan, and transmitted asynchronously for review by pediatric cardiologists in Hawaii. Read More

    Use of 3D printer technology to facilitate surgical correction of a complex vascular anomaly with esophageal entrapment in a dog.
    J Vet Cardiol 2017 Jan 13. Epub 2017 Jan 13.
    Section of Cardiology, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA.
    A 10 week old female intact Staffordshire terrier was presented with a total of five congenital cardio-thoracic vascular anomalies consisting of a patent ductus arteriosus (PDA) with an aneurysmic dilation, pulmonic stenosis, persistent right aortic arch, aberrant left subclavian artery and persistent left cranial vena cava. These abnormalities were identified with a combination of echocardiogram and computed tomography angiography (CTA). The abnormalities were associated with esophageal entrapment, regurgitation, and volume overload of the left heart with left atrial and ventricular enlargement. Read More

    Percutaneous Patent Ductus Arteriosus (PDA) Closure During Infancy: A Meta-analysis.
    Pediatrics 2017 Feb 13;139(2). Epub 2017 Jan 13.
    Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
    Context: Patent ductus arteriosus (PDA) is a precursor to morbidity and mortality. Percutaneous (catheter-based) closure is the procedure of choice for adults and older children with a PDA, but use during infancy (<1 year) is not well characterized.

    Objective: Investigate the technical success and safety of percutaneous PDA closure during infancy. Read More

    Increased urinary neutrophil gelatinase-associated lipocalin in very-low-birth-weight infants with oliguria and normal serum creatinine.
    Pediatr Nephrol 2017 Jan 12. Epub 2017 Jan 12.
    Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, 56 Dalseong-Ro, Jung-gu, Daegu, 700-712, South Korea.
    Background: In infants, oliguria is defined as a urine output of <1.5 mL/kg/h. The aim of our study was to assess the impact of oliguria on urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C (CysC) levels in very-low-birth-weight infants (VLBWIs) with a normal serum creatinine (Cr) level. Read More

    Echocardiographic Versus Angiographic Assessment of Patent Arterial Duct in Percutaneous Closure: Towards X-ray Free Duct Occlusion?
    Pediatr Cardiol 2017 Jan 11. Epub 2017 Jan 11.
    Department of Pediatric Cardiology, Evelina London Children's Hospital, Guys and St Thomas' NHS Foundation Trust, London, UK.
    Device selection and procedural guidance for percutaneous ductal closure strongly rely upon angiographic and echocardiographic imaging. Current literature recognises 2D echocardiography as an essential tool for diagnosis and assessment but does not define a consistent methodology to optimise ductal measurement. There is little research comparing echocardiography with gold standard angiography for ductal measurement. Read More

    Urinary Neutrophil Gelatinase-associated Lipocalin in the evaluation of Patent Ductus Arteriosus and AKI in Very Preterm Neonates: a cohort study.
    BMC Pediatr 2017 Jan 10;17(1). Epub 2017 Jan 10.
    Department of Pediatrics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK 8200, Aarhus, Denmark.
    Background: A patent ductus arteriosus (PDA) is frequently found in very preterm neonates and is associated with increased risk of morbidity and mortality. A shunt across a PDA can result in an unfavorable distribution of the cardiac output and may in turn result in poor renal perfusion. Urinary Neutrophil Gelatinase-associated Lipocalin (U-NGAL) is a marker of renal ischemia and may add to the evaluation of PDA. Read More

    Coronal clival cleft in CHARGE syndrome.
    Neuroradiol J 2017 Jan 1:1971400916678248. Epub 2017 Jan 1.
    1 Department of Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC, USA.
    CHARGE syndrome is a genetic disorder with multi-systemic congenital anomalies, most commonly including coloboma, heart malformations, choanal atresia, developmental delay, and genital and ear anomalies. The diagnostic criteria for CHARGE syndrome has been refined over the years. However, there are limited reports describing skullbase and craniocervical junction abnormalities. Read More

    Lung function in very low birth weight infants after pharmacological and surgical treatment of patent ductus arteriosus - a retrospective analysis.
    BMC Pediatr 2017 Jan 6;17(1). Epub 2017 Jan 6.
    Department of Neonatology, Charité University Medical Centre, Charitéplatz 1, 10117, Berlin, Germany.
    Background: The indications and strategies for treatment of patent ductus arteriosus (PDA) are controversial, and the safety and long-term benefits of surgical PDA closure remain uncertain. The aim of this study was to compare the lung function of very low birth weight (VLBW) infants after successful PDA treatment with a cyclooxygenase inhibitor or secondary surgical ligation.

    Methods: A total of 114 VLBW infants (birth weight < 1500 g), including 94 infants (82%) with a birth weight < 1000 g, who received treatment for hemodynamically significant PDA (hsPDA), were examined at a median postmenstrual age of 48 weeks. Read More

    Evaluation of left pulmonary artery sling, associated cardiovascular anomalies, and surgical outcomes using cardiovascular computed tomography angiography.
    Sci Rep 2017 Jan 5;7:40042. Epub 2017 Jan 5.
    Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
    We evaluated the prevalence, image appearance, associated cardiovascular anomalies, and surgical outcomes of left pulmonary artery sling (LPAS) using cardiovascular computed tomography angiography (CCTA). A retrospective search of patients from our database between October 2007 and December 2014 identified 52,200 patients with congenital heart diseases (CHD) referred for CCTA, echocardiography, or magnetic resonance imaging. Clinical information, CCTA findings, associated cardiovascular anomalies, and surgical outcomes were analyzed. Read More

    Efficacy and safety of rectal ibuprofen for patent ductus arteriosus closure in very low birth weight preterm infants.
    J Matern Fetal Neonatal Med 2017 Jan 25:1-10. Epub 2017 Jan 25.
    a Department of Pediatrics, Division of Neonatology , Yuzuncu Yil University School of Medicine , Van , Turkey.
    Background: To compare rectal ibuprofen with oral ibuprofen for the closure of hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) preterm infants.

    Study Design And Subjects: In a prospective, randomized study, 72 VLBW infants who had hsPDA received either rectal or oral ibuprofen. The plasma concentration of ibuprofen and renal functions were determined in both groups by the high-performance liquid chromatography (HPLC) method and cystatin-C (cys-C), respectively. Read More

    Persistent left superior vena cava accompanying congenital heart disease in children: Experience of a tertiary care center.
    Echocardiography 2017 Jan 3. Epub 2017 Jan 3.
    Department of Pediatric Cardiology, Dr. Sami Ulus Obstetrics and Gynecology, Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
    Background: This study focuses on determining concomitant persistent left superior vena cava (SVC) in patients with congenital heart disease (CHD).

    Methods: Between 2005 and 2012, a total of 2.663 patients with CHD, 88 (3. Read More

    Case report: maternal mosaicism resulting in inheritance of a novel GATA6 mutation causing pancreatic agenesis and neonatal diabetes mellitus.
    Diagn Pathol 2017 Jan 3;12(1). Epub 2017 Jan 3.
    Division of Pediatric Endocrinology Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Decarie, Montreal, H4A 3J1, Quebec, Canada.
    Background: Haploinsufficiency of the GATA6 transcription factor gene was recently found to be the most common cause of pancreatic agenesis, a rare cause of neonatal diabetes mellitus. Although most cases are de novo, we describe three siblings with inherited GATA6 haploinsufficiency and the rare finding of parental mosaicism.

    Case Presentation: The proband was born at term with severe intrauterine growth restriction, the first child of non-consanguineous parents. Read More

    Comparative Effectiveness of Nonsteroidal Anti-inflammatory Drug Treatment vs No Treatment for Patent Ductus Arteriosus in Preterm Infants.
    JAMA Pediatr 2017 Jan 3:e164354. Epub 2017 Jan 3.
    Department of Pediatrics, The Ohio State University College of Medicine and Nationwide Children's Hospital, Columbus2Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
    Importance: Patent ductus arteriosus (PDA) is associated with increased mortality and worsened respiratory outcomes, including bronchopulmonary dysplasia (BPD), in preterm infants. Nonsteroidal anti-inflammatory drugs (NSAIDs) are efficacious in closing PDA, but the effectiveness of NSAID-mediated PDA closure in improving mortality and preventing BPD is unclear.

    Objective: To determine the effectiveness of NSAID treatment for PDA in reducing mortality and moderate/severe BPD at 36 weeks postmenstrual age. Read More

    Echocardiographic assessment of patent ductus arteriosus in very low birthweight infants over time: prospective observational study.
    J Matern Fetal Neonatal Med 2017 Jan 23:1-12. Epub 2017 Jan 23.
    a Division of Neonatology, Department of Pediatrics , College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.
    Background: We aimed to determine the echocardiographic parameters that can predict the presence of patent ductus arteriosus (PDA) and haemodynamically significant ductus arteriosus (HSDA) at different time points.

    Methods: Echocardiogram was performed on postnatal days 3 and 7(D3-Echo and D7-Echo, respectively) in 71 very low birthweight infants with a median gestational age of 28.0 weeks. Read More

    A conservative treatment of patent ductus arteriosus in very low birth weight infants.
    Early Hum Dev 2017 Jan 30;104:45-49. Epub 2016 Dec 30.
    Department of Paediatric and Newborn Medicine, Coombe Women and Infants University Hospital, Dublin, Ireland; Neonatal Intensive Care Unit, Institute for the Care of Mother and Child, Prague, Czech Republic; UCD School of Medicine, Dublin, Ireland; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:
    Background: Treatment of the patent ductus arteriosus (PDA) in the preterm infant remains contentious. There are numerous options of the PDA management from early targeted treatment, late (symptomatic) treatment to no treatment at all.

    Aims: To evaluate a three different PDA management approaches in very low birth weight (VLBW) infants. Read More

    [Management of patent ductus arteriosus in preterm infants: An evidence-based approach].
    Arch Pediatr 2017 Feb 29;24(2):175-179. Epub 2016 Dec 29.
    Service de cardiologie pédiatrique, hôpital de la mère et de l'enfant, 7, quai Moncousu, 44000 Nantes, France. Electronic address:
    A patent ductus arteriosus, very common in the preterm infant (incidence up to 70% in infants less than 28 weeks gestational age), causes a left-to-right shunt leading to overload of the pulmonary circulation and low systemic blood flow. These hemodynamic anomalies are associated with a higher incidence of respiratory, neurological, and digestive complications of prematurity, as well as a higher mortality rate. Although growing knowledge about the natural history, the pathophysiology, and the mechanisms of closure of the ductus arteriosus has resulted in therapeutic progress, management of the patent ductus arteriosus in the preterm infant is still a subject of intense controversy. Read More

    Screening for retinopathy of prematurity and treatment outcome in a tertiary hospital in Hong Kong.
    Hong Kong Med J 2017 Feb 30;23(1):41-7. Epub 2016 Dec 30.
    Department of Ophthalmology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.
    Introduction: Studies on the prevalence and severity of retinopathy of prematurity in the local population are scarce. This study aimed to evaluate the prevalence, screening, and treatment outcome of retinopathy of prematurity in a tertiary hospital in Hong Kong.

    Methods: This cross-sectional study with internal comparison was conducted at Queen Mary Hospital, Hong Kong. Read More

    A Case of Patent Ductus Arteriosus in an Elderly Patient Treated by Thoracic Endovascular Aortic Repair.
    Ann Vasc Dis 2016 7;9(4):326-329. Epub 2016 Sep 7.
    Department of Radiology, Aichi Medical University, Nagakute, Aichi, Japan.
    The patient described herein was a 75-year-old female. Echocardiography showed patent ductus arteriosus (PDA). Heart failure symptoms gradually appeared, and she was referred to our department for treatment. Read More

    Evaluation of maternal health and labor and delivery conditions as risk factors for childhood leukemias in children with Down syndrome.
    Cancer Epidemiol 2017 Feb 22;46:36-41. Epub 2016 Dec 22.
    Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX 78714. Electronic address:
    Children with Down syndrome (DS) have a remarkably high risk of developing leukemia during childhood; the mechanisms driving that risk are not well understood, and no clear prevention strategies exist. We conducted a nested case-control study in a Texas DS birth cohort to investigate possible links between maternal health, labor/delivery conditions, and leukemia risk. For most of the factors studied there was no evidence of an increased risk of total leukemias, or the subtypes acute lymphoid or acute myeloid leukemia. Read More

    'End-stage' heart failure therapy: potential lessons from congenital heart disease: from pulmonary artery banding and interatrial communication to parallel circulation.
    Heart 2017 Feb 23;103(4):262-267. Epub 2016 Dec 23.
    Pediatric Heart Center, Justus Liebig University Giessen, Virginia Commonwealth University, School of Pharmacy, Richmond, Virginia, USA.
    The final therapy of 'end-stage heart failure' is orthotopic heart, lung or heart-lung transplantation. However, these options are not available for many patients worldwide. Therefore, novel therapeutical strategies are needed. Read More

    Use of stent-grafts for the ductus arteriosus and its related lesions.
    Asian Cardiovasc Thorac Ann 2016 Jan 1:218492316686478. Epub 2016 Jan 1.
    1 Department of Cardiovascular Surgery, Matsue Red Cross Hospital, Shimane, Japan.
    Five cases of ductal lesions with various anatomies have been successfully treated by thoracic endovascular aortic replacement in recent years; 4 using mainly fenestrated stent-grafts, and one using a non-fenestrated stent-graft. Considering the invasive nature of open surgery and the anatomical limitations of the catheter technique for occluding a patent ductus in many adult cases, thoracic endovascular aortic replacement should be the first option because of its broad applicability for ductal lesions. Read More

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