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Microb Pathog 2020 Jul 6:104380. Epub 2020 Jul 6.

Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China; Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China. Electronic address:

Pasteurella multocida possesses a viscous capsule polysaccharide on the cell surface, which is a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. Based on the capsular antigen, P. Read More

Vet Microbiol 2020 Jul 2;246:108748. Epub 2020 Jun 2.

Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan; Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan; Center for Animal Disease Control, University of Miyazaki, Miyazaki, Japan. Electronic address:

The synergistic infection of bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) may predispose cattle to develop severe pneumonia. Previously, we reported that BRSV infection significantly decreased PM adherence to the upper respiratory epithelial cells. It may allow bacteria to invade into the lower respiratory tract and lead to severe pneumonia. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Jun 26. Epub 2020 Jun 26.

Service d'ORL et CCF, Hôpital Huriez, CHU de Lille, 1 place de Verdun, 59037 Lille cedex, France; INSERM U 908, Université des Sciences et Technologies de Lille, UFR de Biologie - SN3, 59655 Villeneuve d'Ascq, France. Electronic address:

Introduction: Apart from cases related to direct inoculation, pasteurellosis is a rare opportunistic infection occurring in predisposed subjects. Close contact with domestic animals, usually cats, is generally reported. Localized ENT forms are possible and are due to oropharyngeal carriage. Read More

Genet Sel Evol 2020 Jun 26;52(1):34. Epub 2020 Jun 26.

GenPhySE, INRAE, ENVT, Université de Toulouse, 31326, Castanet-Tolosan, France.

Background: Pasteurellosis (Pasteurella infection) is one of the most common bacterial infections in rabbits on commercial farms and in laboratory facilities. Curative treatments using antibiotics are only partly efficient, with frequent relapses. Breeding rabbits for improved genetic resistance to pasteurellosis is a sustainable alternative approach. Read More

Front Vet Sci 2020 2;7:304. Epub 2020 Jun 2.

Section Veterinary Public Health, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.

Respiratory tract infections (RTIs) associated with , Streptococci, Staphylococci, and species have been reported in dogs. The objective of this study was to investigate the occurrence and predictors of bacterial RTIs and antimicrobial resistance among samples from dogs with lower RTIs at a referral veterinary teaching hospital in South Africa. Records of 157 dogs with lower RTIs presented to the veterinary teaching hospital between 2007 and 2013 were included in the study. Read More

Vector Borne Zoonotic Dis 2020 Jun 22. Epub 2020 Jun 22.

Division of Pediatric Infectious Diseases, The Children's Hospital at Saint Peter's University Hospital, New Brunswick, New Jersey, USA.

This is a case of septic shock encountered in a 7-week-old infant without any bites, scratch marks, or history of licks by pet animals (dog and cats in household). The infant required 3 days of vasopressor support and 4 days of mechanical ventilation to achieve normal hemodynamics. This is an unidentified route of transmission and our literature search for this topic discovered reported cases of life-threatening presentation with infections in the absence of a bite or any form of invasive contact with animals. Read More

BMC Vet Res 2020 Jun 9;16(1):186. Epub 2020 Jun 9.

Research Centre for Ruminant Diseases, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Malaysia.

Background: Pasteurella multocida B:2 causes haemorrhagic septicaemia in cattle and buffaloes. However, buffaloes are found to be more susceptible to the infection than cattle. Upon infection, the pathogen rapidly spread from the respiratory tract to the blood circulation within 16-72 h, causing septicaemia. Read More

Vaccines (Basel) 2020 Jun 6;8(2). Epub 2020 Jun 6.

Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1, Shuefu Road, Neipu, Pingtung 91201, Taiwan.

Flagellin from bacteria elicits a proinflammatory immune response and may act as a vaccine adjuvant. In this study, we evaluated the adjuvant effect of the N-terminus of flagellin (residues 1-99) when linked to an antigen (a truncated, conserved domain of lipoprotein E of ). Immunization of chickens with the antigen-adjuvant chimeric protein showed that the N-terminus of flagellin accelerated the antibody response and enhanced the cellular immunity (CD8 T cell expansion). Read More

Prog Mol Biol Transl Sci 2020 9;171:131-193. Epub 2020 Apr 9.

Department of Oncology, Wayne State University School of Medicine, Detroit, MI, United States; Department of Pathology, Wayne State University School of Medicine, Detroit, MI, United States. Electronic address:

Growing evidence suggests that imbalances in resident microbes (dysbiosis) can promote chronic inflammation, immune-subversion, and production of carcinogenic metabolites, thus leading to neoplasia. Yet, evidence to support a direct link of individual bacteria species to human sporadic cancer is still limited. This chapter focuses on several emerging bacterial toxins that have recently been characterized for their potential oncogenic properties toward human orodigestive cancer and the presence of which in human tissue samples has been documented. Read More

IDCases 2020 11;21:e00801. Epub 2020 May 11.

Department of Hospital Medicine, Marshfield Clinic Health System - Marshfield, Marshfield, WI, 54444, United States.

() is a gram-negative coccobacillus that comprises the normal oral, upper respiratory, and gastrointestinal flora of many wild and domestic animals. Disease transmission primarily occurs via animal bites, scratches, and licks on broken skin. most commonly causes skin and soft tissue infection and local abscess formation; however, we report a unique case of spinal epidural abscess due to infection in a patient with a history of recent epidural steroid injection and repeated cat bites. Read More

Comp Immunol Microbiol Infect Dis 2020 May 11;71:101494. Epub 2020 May 11.

Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Brazil; Multi-User Animal Health Laboratory, Molecular Biology Unit, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Brazil; National Institute of Science and Technology for Dairy Production Chain, (INCT - LEITE), Universidade Estadual de Londrina, Brazil.

The etiological agents involved in a bovine respiratory disease (BRD) outbreak were investigated in a dairy heifer calf rearing unit from southern Brazil. A battery of PCR assays was performed to detect the most common viruses and bacteria associated with BRD, such as bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), bovine alphaherpesvirus 1 (BoHV-1), bovine coronavirus (BCoV), bovine parainfluenza virus 3 (BPIV-3), Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. Bronchoalveolar lavage fluid (BALF) samples were taken from 21 heifer calves (symptomatic n = 15; asymptomatic n = 6) that, during the occurrence of the BDR outbreak, were aged between 6 and 90 days. Read More

Vector Borne Zoonotic Dis 2020 May 18. Epub 2020 May 18.

Department of Family Practice, St Luke's University Health Network, Phillipsburg, New Jersey, USA.

Pasteur discovered the causative agent of fowl cholera () in 1880. Since then, multiple zoonotic infections affecting humans have been reported. infections usually result from bites of cats or dogs. Read More

Acta Vet Hung 2020 May 4. Epub 2020 May 4.

1Department of Animal Health (AGR-149), Campus of International Agri-Food Excellence CeiA3, Edificio Sanidad Animal 2Planta, Campus Universitario Rabanales, University of Córdoba, 14014, Córdoba, Spain.

This paper describes the first documented outbreak of haemorrhagic septicaemia (HS) caused by Pasteurella multocida type B in cattle in Spain. This acute, highly fatal septicaemia causes major economic losses in cattle and buffaloes in many areas of Asia and Africa. In other species and in European countries it is an infrequently reported disease. Read More

Vet Clin North Am Food Anim Pract 2020 Jul 21;36(2):253-268. Epub 2020 Apr 21.

Food Animal Health and Management Program, Department of Population Health, College of Veterinary Medicine, University of Georgia, Veterinary Medical Center, 2200 College Station Road, Athens, GA 30602, USA. Electronic address:

The bacteria Mannheimia haemolytica and Pasteurella multocida contribute to bovine respiratory disease (BRD), which is often managed with antimicrobials. Antimicrobial resistance in these bacteria has been rare, but extensively drug-resistant strains have recently become common. Routine antimicrobial use may be driving this resistance. Read More

Am J Ophthalmol Case Rep 2020 Jun 16;18:100711. Epub 2020 Apr 16.

Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.

Purpose: To report the case of a Japanese girl with a perforating ocular injury caused by a cat scratch, resulting in Pasteurella multocida-induced endophthalmitis.

Observations: A 10-year-old girl presented with a red eye, eye pain, and blurred vision in her right eye immediately after receiving a cat scratch. We performed lensectomy and vitrectomy for endophthalmitis 4 hours after her arrival. Read More

Sci Rep 2020 Apr 14;10(1):6340. Epub 2020 Apr 14.

Department of Basic Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.

Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Read More

Vet Microbiol 2020 Apr 19;243:108646. Epub 2020 Mar 19.

College of Animal Science and Technology, Southwest University, Chongqing, 400715, China. Electronic address:

Pasteurella multocida is a gram-negative bacterial pathogen, which causes a large number of diseases in mammals, birds and human. Although the bacterium has been known for decades, the pathogenesis and the mechanisms of P. multocida induced host immunity are poorly understood. Read More

BMC Nephrol 2020 Mar 19;21(1):102. Epub 2020 Mar 19.

Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Background: P. multocida (Pasteurella multocida) is animal-sourced gram-negative coccobacillus which can be transmitted to human through many animals including household pets. P. Read More

Dose Response 2020 Jan-Mar;18(1):1559325820904858. Epub 2020 Feb 4.

Department of Eastern Medicine, Government College University Faisalabad, Pakistan.

Multidrug resistance has increased globally in the communities. Bacterial infections associated with health care have weakened the existing antimicrobial therapy and demand the search for alternative therapies. In the present investigation, the medicinal plant from Quetta, Pakistan, has been screened for antimicrobial potential. Read More

Vet World 2019 Dec 26;12(12):2061-2069. Epub 2019 Dec 26.

Department of Bacteriology, Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agricultural Research Centre, Nadi El-Seid St., P.O. Box 246, Dokki, Giza 12618, Egypt.

Aim: A total of 112 freshly dead ducks aged from 2 to 20 weeks old with a history of respiratory manifestations were investigated for the implication of family members.

Materials And Methods: Isolation and identification to the family level were conducted by conventional bacteriological methods, including microscopic examination and biochemical characterization. Identification to the species level was conducted by polymerase chain reaction (PCR) and analytical profile index (API) 20E kits. Read More

Anim Health Res Rev 2019 12;20(2):274-290

Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

A systematic review and network meta-analysis (MA) was conducted to address the question, 'What is the efficacy of bacterial vaccines to prevent respiratory disease in swine?' Four electronic databases and the grey literature were searched to identify clinical trials in healthy swine where at least one intervention arm was a commercially available vaccine for one or more bacterial pathogens associated with respiratory disease in swine, including Mycoplasma hyopneumoniae, Actinobacillus pleuropneumonia, Actinobacillus suis, Bordetella bronchiseptica, Pasteurella multocida, Stretococcus suis, Haemophils parasuis, and Mycoplasma hyorhinis. To be eligible, trials had to measure at least one of the following outcomes: incidence of clinical morbidity, mortality, lung lesions, or total antibiotic use. There were 179 eligible trials identified in 146 publications. Read More

Germs 2019 Dec 2;9(4):193-197. Epub 2019 Dec 2.

MD, PhD, Clinic for Pulmonology, Clinical Centre of Serbia, Koste Todorovica 26, 11000 Belgrade, Serbia.

Introduction: colonizes the oropharynx of various domestic and wild animals. In humans, respiratory tract infection is the second most frequent localization and usually manifests as pneumonia. Unilateral absence of pulmonary artery (UAPA) is a very rare congenital anomaly. Read More

Poult Sci 2020 Feb 26;99(2):783-790. Epub 2019 Dec 26.

Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.

In the Mekong Delta region of Vietnam, small-scale chicken farming is common. However, high levels of disease or mortality in such flocks impair economic development and challenge the livelihoods of many rural households. We investigated 61 diseased small-scale flocks (122 chickens) for evidence of infection with 5 bacteria, 4 viruses, and helminths. Read More

QJM 2020 Feb 4. Epub 2020 Feb 4.

Division of Infectious Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Pasteurella multocida, a zoonotic infectious pathogen, is a rare cause of mycotic aneurysms in human hosts. A 61-year-old male patient with myelodysplastic syndromes (MDS) was admitted due to fever, chills, and malaise. He had been frequently licked by his pet dog. Read More

J Dairy Sci 2020 Mar 15;103(3):2556-2566. Epub 2020 Jan 15.

Animal Health Service Flanders (DGZ Vlaanderen), Industrielaan 29, 8820 Torhout, Belgium.

Respiratory tract infections (bovine respiratory disease) are a major concern in calf rearing. The objective of this study was to identify pathogen-specific risk factors associated with epidemic respiratory disease in calves. A cross-sectional study was conducted, involving 128 outbreaks (29 dairy, 58 dairy-mixed, and 41 beef) in Belgium (2016-2018). Read More

Case Rep Nephrol 2019 9;2019:5150695. Epub 2019 Dec 9.

Alabama College of Osteopathic Medicine, 445 Health Sciences Blvd, Dothan, AL 36303, USA.

is an aerobic gram-negative coccobacillus usually found in the oral cavities of most healthy cats and dogs as part of their natural oral flora. This zoonotic pathogen can cause a variety of infections in humans through bites, scratches, or licking. Infections range from less severe cases, such as infected animal bites and cellulitis, to more severe cases of pneumonia, septic arthritis, osteomyelitis, sepsis, and meningitis. Read More

Avian Pathol 2020 Jun 22;49(3):221-229. Epub 2020 Jan 22.

Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.

Fowl cholera is a highly contagious disease within the global duck farming industry. This study aimed at formulating and evaluating the protective efficacy of a combination vaccine containing a recombinant outer membrane protein H (rOmpH) of strain X-73 with a live attenuated duck plague vaccine into a single dose. Four groups of ducks received different treatments and the groups were labelled as non-vaccinated, combined vaccination, duck plague vaccination and rOmpH vaccination, respectively. Read More

J Vet Med Sci 2020 Feb 23;82(2):217-223. Epub 2019 Dec 23.

Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Fuchu, Tokyo 183-8509, Japan.

The etiology of Porcine respiratory disease complex is complicated by infections with multiple pathogens, and multiple infections increase the difficulty in identifying the causal pathogen. In this present study, we developed a detection system of microbes from porcine respiratory by using TaqMan real-time PCR (referred to as Dempo-PCR) to screen a broad range of pathogens associated with porcine respiratory diseases in a single run. We selected 17 porcine respiratory pathogens (Actinobacillus pleuropneumoniae, Boldetella bronchiseptica, Haemophilus parasuis, Pasteurella multocida, Pasteurella multocida toxin, Streptococcus suis, Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Mycoplasma hyosynovie, porcine circovirus 2, pseudorabies virus, porcine cytomegalovirus, swine influenza A virus, porcine reproductive and respiratory virus US strain, EU strain, porcine respiratory coronavirus and porcine hemagglutinating encephalomyelitis virus) as detection targets and designed novel specific primer-probe sets for seven of them. Read More

Rev Chilena Infectol 2019 Oct;36(5):667-669

Instituto de Cardiología, Bogotá, Colombia.

Pasteurella species are known to be one of the most frequently isolated in oral microbiota of domestic and wild animals, because of that, they are associated with skin and soft tissues infections secondary to bites and scratches. Systemic infections are uncommon, but are associated with dissemination from localized infections and some risks factors related to immunosuppression. We report a case of Pasteurella multocida bacteremia in an 88 years old patient, associated with food sharing with his dog; a bacteremia mechanism never described before in the medical literature. Read More

Genes Genomics 2020 02 18;42(2):235-243. Epub 2019 Dec 18.

Department of Cell Biology, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan, 49267, Korea.

Background: Although Pasteurella multocida is highly prevalent pathogen in animals and plays an important role in swine respiratory diseases, only a few studies on the use of bacteriophages specific to Pasteurella multocida disease have been reported.

Objective: The object of this study was to investigate the therapeutic effect of specific P. multocida bacteriophages and to identify genes related to bacteriophage signaling utilizing RNA microarrays in swine nasal turbinate cells. Read More

Acta Vet Hung 2019 12;67(4):489-498

Animal Health Department, Veterinary School, Universidad Complutense de Madrid, Av. Puerta de Hierro, s/n, 28040 Madrid, Spain.

is responsible for economically important diseases in sheep and pigs. Antimicrobial susceptibility studies are essential for initiating rational and effective empirical therapy of infections. In this study we investigated the antimicrobial susceptibility to 18 antimicrobial agents of 156 clinical isolates of from sheep (n = 87) and pigs (n = 69) using the microdilution method. Read More

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619895165

Ashland Bellefonte Cancer Center, Ashland, KY, USA.

Peritonitis caused by gram-negative organisms is a significant complication encountered in patients undergoing peritoneal dialysis and is associated with high morbidity and mortality. There has been recognition of peritonitis caused by uncommon organisms because of improved microbiological detection techniques. In this article, we report a rare case of peritonitis caused by . Read More

PLoS One 2019 13;14(12):e0219104. Epub 2019 Dec 13.

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States of America.

Although 90% of BRD relapses are reported to receive retreatment with a different class of antimicrobial, studies examining the impact of antimicrobial selection (i.e. bactericidal or bacteriostatic) on retreatment outcomes and the emergence of antimicrobial resistance (AMR) are deficient in the published literature. Read More

Microb Pathog 2020 Mar 10;140:103911. Epub 2019 Dec 10.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:

Pasteurella multocida capsular type A can cause a pulmonary infection, leading to serious pecuniary losses in cattle. The heterogeneity of infection outcome of P. multocida strains showing different virulence may be related to divergent expression of virulence genes. Read More

BMC Vet Res 2019 Dec 4;15(1):438. Epub 2019 Dec 4.

Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, No. 100 Pudang Road, Xindian Town, Jin'an District, Fuzhou, Fujian Province, People's Republic of China.

Background: Pasteurella multocida is one of the important pathogens that infect rabbits, causing major economic losses in commercial rabbit farming. In this study, 205 P. multocida isolates recovered from lungs of dead rabbits with respiratory disease were defined by capsular serogroups, lipopolysaccharide (LPS) genotypes, multi-locus sequence types and screened virulence factors by using PCR assays, and tested antimicrobial susceptibility. Read More

Case Rep Infect Dis 2019 3;2019:1964161. Epub 2019 Nov 3.

Head Section of Infectious Diseases, Department of Internal Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

is a small, Gram-negative, facultatively anaerobic coccobacillus that inhabits the normal microbiota of the respiratory tract of several animals, especially cats and dogs. By infecting humans, a wide range of clinical pictures can evolve varying from mild local cellulitis to more severe systemic diseases (e.g. Read More

Res Vet Sci 2020 Feb 13;128:118-123. Epub 2019 Nov 13.

Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Faculty of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang District, Harbin, PR China; Department of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang 150030, PR China. Electronic address:

The aim of this study is to evaluate the safety and efficacy of gamithromycin (GAM) for the treatment of naturally occurring bacterial swine respiratory disease (SRD) administered IM. A total of 240 pigs (nine-weeks old) were selected from two sites in Heilongjiang Province of China. The pigs showed severe signs of respiratory disease. Read More

Front Microbiol 2019 30;10:2430. Epub 2019 Oct 30.

Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.

Potential synergism between florfenicol (FF) and thiamphenicol (TAP) was investigated for efficacy against and/or as well as efficacy in swine. Among isolates of ( = 58) and ( = 79) from pigs in Taiwan that were tested, high percentages showed resistance to FF (52 and 53%, respectively) and TAP (57 and 53%, respectively). Checkerboard microdilution assay indicated that synergism [fractional inhibitory concentration index (FICI) ≤ 0. Read More

AMB Express 2019 Nov 14;9(1):185. Epub 2019 Nov 14.

Shanghai Veterinary Research Institute, The Chinese Academy of Agricultural Sciences (CAAS), 518 Ziyue Road, Shanghai, 200241, People's Republic of China.

Escherichia coli, Pasteurella multocida, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella spp. and Staphylococcus aureus are six bacterial pathogens of avian. However, these pathogens may cause many similar pathological changes, resulting in clinical isolates that are difficult to quickly and simultaneously detect and identify. Read More

Front Pharmacol 2019 24;10:1090. Epub 2019 Sep 24.

Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

Gamithromycin is approved for the treatment and prevention of bovine respiratory disease (BRD), which is caused mainly by , and species. In this study, multiple dosage regimens were administered to the neutropenic mouse lung infection model in order to investigate the pharmacokinetic/pharmacodynamic (PK/PD) parameters of gamithromycin treatment of and to further define the PK/PD parameter that best correlates with the efficacy of gamithromycin against . The PK characteristics of gamithromycin were analyzed after a single subcutaneous (s. Read More

Res Vet Sci 2019 Dec 25;127:82-90. Epub 2019 Oct 25.

Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China. Electronic address:

Pasteurella multocida possesses a polysaccharide capsule composed of a viscous surface layer that acts as a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. In recent years, a series of important research advances have been made in understanding the biosynthesis and regulatory aspects of the P. Read More

Proc (Bayl Univ Med Cent) 2019 Oct 22;32(4):574-576. Epub 2019 Jul 22.

Division of Infectious Disease, Department of Internal Medicine, Baylor Scott & White HealthTempleTexas.

is a bipolar staining gram-negative coccobacillus that resides in the nasopharynx of many animals, most notably felines. It is a common cause of soft tissue infections following animal bites but has rarely been reported to cause epiglottitis. Here we describe a case of epiglottitis and bacteremia due to following exposure to a feral cat. Read More

Br J Dermatol 2020 Jul 2;183(1):105-113. Epub 2019 Dec 2.

Department of Microbiology, AP-HP, Henri Mondor University Hospital, Université Paris-Est, Créteil, France.

Background: Necrotizing soft-tissue infections (NSTIs) are life threatening, requiring broad-spectrum antibiotics. Their aetiological diagnosis can be limited by poor performance of cultures and administration of antibiotics before surgery.

Objectives: We aimed (i) to compare 16S-targeted metagenomics (TM) and unbiased semiquantitative panmicroorganism DNA- and RNA-based shotgun metagenomics (SM) with cultures, (ii) to identify patients who would best benefit from metagenomics approaches and (iii) to detect the microbial pathogens in surrounding non-necrotic 'healthy' tissues by SM-based methods. Read More

Infect Immun 2019 12 18;87(12). Epub 2019 Nov 18.

College of Animal Science and Technology, Southwest University, Chongqing, China

causes a variety of infectious diseases in various species of mammals and birds, resulting in enormous economic loss to the modern livestock and poultry industry. However, the mechanism of host-pathogen interaction is unclear. Here, we found that l-serine levels were significantly decreased in murine lungs infected with Exogenous l-serine supplementation significantly increased the survival rate of mice and decreased the colonization of in the lungs of mice. Read More

J Dairy Sci 2019 Dec 20;102(12):11359-11369. Epub 2019 Sep 20.

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706. Electronic address:

The primary objective of this randomized controlled challenge study was to investigate the effect of ampicillin on ultrasonographic (US) lung consolidation after experimental challenge with Pasteurella multocida in preweaned dairy calves. The secondary objectives were to determine whether ampicillin affected respiratory score, gross consolidation, or the detection of P. multocida in lung tissue at postmortem exam (PME). Read More

Vet World 2019 Jul 3;12(7):945-950. Epub 2019 Jul 3.

Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.

Background And Aim: The current vaccination for peste des petits ruminants virus (PPRV) is stalled by myriad challenges and continuous endemicity of pneumonia due to fulminant bacterial complication in goats. The present study evaluated the protective effect of intranasal PPRV linage 1 and bacterine vaccinations.

Materials And Methods: Twelve West African Dwarf (WAD) goats aged 6 months were randomly grouped and vaccinated within 2 weeks using a combination of PPRV lineage 1 vaccine (Nig/75), and bacterin from (Mh) or intranasally. Read More

IDCases 2019 24;18:e00630. Epub 2019 Aug 24.

Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.

is frequently associated with soft tissue infections related to animal bites or scratches. These infections are usually mild but can lead to serious complications especially in high-risk patients. We present a chronic vertebral osteomyelitis with extensive spondylodiscitis, myositis and epidural abscess in a patient with diabetes and liver cirrhosis. Read More

Lett Appl Microbiol 2019 Nov 9;69(5):366-372. Epub 2019 Oct 9.

Faculty of Science, Institute of Science Biology, University of Malaya, Kuala Lumpur, Malaysia.

We evaluate the efficacy of recombinant DNA vaccine ABA392 against haemorrhagic septicaemia infection through intranasal administration route by targeting the mucosal immunity. The DNA vaccine was constructed and subjected to animal study using the Sprague Dawley (SD) rat. The study was divided into two major parts: (i) active and (ii) passive immunization studies, involving 30 animals for each part. Read More

Vet Microbiol 2019 Sep 22;236:108363. Epub 2019 Jul 22.

Clinic for Ruminants, Vetsuisse Faculty, University of Bern, Switzerland. Electronic address:

Antimicrobial consumption, with bovine respiratory disease as main indication, is higher in the veal calf industry compared to other livestock production branches. The aim of the present study was to investigate possible associations between antimicrobial drug use and resistance in Pasteurellaceae and indicator Escherichia (E.) coli from veal calves under field conditions in a prospective trial. Read More