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Animals (Basel) 2022 Jun 13;12(12). Epub 2022 Jun 13.

Hainan Key Laboratory of Tropical Animal Reproduction & Breeding and Epidemic Disease Research, Engineering Key Lab of Haikou, College of Animal Science and Technology, Hainan University, Haikou 570228, China.

(Pm) infection causes severe respiratory disease in goats. We investigated the effects of the Pm infection intratracheally on the histopathology, miRNA and mRNA expression dynamics in the lung of goats infected for 1, 2, 5 and 7 days. Pm infection caused fever, which significantly ( < 0. Read More

Vet Sci 2022 Jun 18;9(6). Epub 2022 Jun 18.

Department of Veterinary Medicine, University of Bari "Aldo Moro", S. P. Casamassima km 3, 70010 Valenzano, Italy.

The number of pets such as dogs, cats, rabbits, and parrots has increased in European families. Social benefits to owners such as decreasing feelings of loneliness and anxiety are provided by pets which are also used in Animal-assisted Therapy (AAT). Nevertheless, human-animal interactions are also associated with health problems including allergies, asthma, and zoonosis. Read More

J Community Hosp Intern Med Perspect 2022 12;12(2):50-52. Epub 2022 Apr 12.

Internal Medicine, UPMC Harrisburg, PA, USA.

Background: is a gram-negative pathogen commonly associated with soft tissue infections caused by bites or scratches from household animals. However, infections have been reported without prior zoonotic exposure or associated soft tissue or skin infection in immunocompromised individuals.

Case: A 73-year-old patient with history significant for multiple malignancies including lung cancer presented to the emergency department with a fever, chills, and rigor. Read More

Front Vet Sci 2022 25;9:895492. Epub 2022 May 25.

Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Brazil.

Bovine respiratory disease (BRD) is considered a major cause of morbidity and mortality in young calves and is caused by a range of infectious agents, including viruses and bacteria. This study aimed to determine the frequency of viral and bacterial pathogens detected in calves with BRD from high-production dairy cattle herds and to perform the molecular characterization of N and S1 genes in identified bovine coronavirus (BCoV) strains. Nasal swabs were collected from 166 heifer calves, namely, 85 symptomatic and 81 asymptomatic calves aged between 5 and 90 days, from 10 dairy cattle herds. Read More

Cureus 2022 Apr 23;14(4):e24414. Epub 2022 Apr 23.

Infectious Disease, Moffitt Cancer Center, Tampa, USA.

Cats and dogs make up an essential part of the household for families in the United States. Close contact with pets can carry a risk of potential infectious disease transmission. This case series outlines causes of zoonotic pneumonia associated with cats and dogs, with a particular focus on the three cases presented of respiratory infection with and in patients with an underlying malignancy. Read More

Vaccine 2022 Jun 20;40(27):3771-3780. Epub 2022 May 20.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; MARA Key Laboratory of Development of Veterinary Diagnostic Products, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Dermonecrotic toxin (DNT) is an important bacterial virulence factor produced by the zoonotic pathogens Bordetella bronchiseptica and Pasteurella multocida. This study aims to explore the possibility of expressing different fragments of P. multocida toxin (PMT) in the chromosome of attenuated B. Read More

Cureus 2022 Apr 16;14(4):e24188. Epub 2022 Apr 16.

Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, USA.

We report the fiftieth case in the literature of species peritoneal dialysis (PD)-related peritonitis and the third reported case of bacteremia associated with PD-related peritonitis. Our review provides the most up-to-date collection of all fifty reported cases of PD-related peritonitis caused by  species. A 77-year-old Caucasian male with a past medical history significant for new-onset left-ventricular systolic heart failure, severe mitral valve regurgitation, and end-stage renal disease on PD for six months presented to the emergency department with a one-week cloudy peritoneal effluent and intermittent abdominal pain. Read More

J Vet Res 2022 Mar 25;66(1):109-116. Epub 2022 Mar 25.

School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.

Introduction: Bovine respiratory disease (BRD) is one of the primary causes of death in young calves. Vaccination against infection by the common bacteria causing BRD is possible; however, the physical condition of the young calves that enables antibody production when stimulated by early immunisation remains to be elucidated.

Material And Methods: Healthy young female Holstein calves on a commercial dairy farm were fed a colostrum replacer and administered primary and booster immunisations with an inactivated vaccine against the bacterial pneumonia agents , and . Read More

Lancet Microbe 2022 Jan 11;3(1):e6. Epub 2021 Nov 11.

IHU Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, MEPHI, IHU Méditerranée Infection, 13385 Marseille, France; Laboratoire de Microbiologie, Assistance Publique-Hôpitaux de Marseille, IHU Méditerranée Infection, Marseille, France. Electronic address:

Cureus 2022 Apr 8;14(4):e23962. Epub 2022 Apr 8.

Ophthalmology, Hospital Raja Permaisuri Bainun, Perak, MYS.

is a rare but aggressive causative organism in panophthalmitis. It is commonly transmitted to humans through contact with cats and dogs as a result of bites or scratches. We report a rare case of panophthalmitis due to following an industrial penetrating injury. Read More

Poult Sci 2022 Jul 15;101(7):101860. Epub 2022 Mar 15.

Yancheng Engineering Research Center of Animal Biologics, College of Marine and Biological Engineering, Yancheng Teachers University, Yancheng 224002, China. Electronic address:

Mycoplasma synoviae (MS) is an important avian pathogen that has brought substantial economic losses to the global poultry industry. Fast and accurate diagnosis is one of the critical factors for the control of MS infection. This study established a simple, rapid and visual detection method for MS using a recombinase-aided amplification (RAA) combined with a lateral flow dipstick (LFD). Read More

J Ind Microbiol Biotechnol 2022 May 10. Epub 2022 May 10.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

A structurally unique aminoglycoside produced in Streptoalloteichus tenebrarius, Apramycin is used in veterinary medicine or the treatment of Salmonella, Escherichia coli and Pasteurella multocida infections. Although apramycin was discovered nearly 50 years ago, many biosynthetic steps of apramycin remain unknown. In this study, we identified a HemK family methyltransferase, AprI, to be the 7'-N-methyltransferase in apramycin biosynthetic pathway. Read More

Cureus 2022 Apr 8;14(4):e23948. Epub 2022 Apr 8.

Nephrology, Carilion New River Valley Medical Center, Christiansburg, USA.

Peritoneal dialysis (PD) is an effective modality for renal replacement therapy. A serious complication that can arise from PD is peritonitis. Over the last few decades, there have been cases of PD-related peritonitis secondary to infections We present the case of a 44-year-old female who presented to the emergency department with a one-day history of abdominal pain and cloudy peritoneal fluid on evaluation. Read More

Dis Model Mech 2022 05 6;15(5). Epub 2022 Jun 6.

Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.

To elucidate the molecular mechanisms that manifest lung abnormalities during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole-transcriptome sequencing of lung autopsies from 31 patients with severe COVID-19 and ten uninfected controls. Using metatranscriptomics, we identified the existence of two distinct molecular signatures of lethal COVID-19. The dominant 'classical' signature (n=23) showed upregulation of the unfolded protein response, steroid biosynthesis and complement activation, supported by massive metabolic reprogramming leading to characteristic lung damage. Read More

Pediatr Infect Dis J 2022 06 6;41(6):e267-e268. Epub 2022 May 6.

From the Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

A 33-day-old previously healthy term female is admitted to the pediatric intensive care unit with fever, lethargy and bulging fontanel. Given concern for meningitis, a lumbar puncture is performed and empiric treatment is initiated. The cerebrospinal fluid culture results reveal Pasteurella multocida. Read More

BMJ Case Rep 2022 Apr 15;15(4). Epub 2022 Apr 15.

Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

A woman in her late 40s who works as a veterinary technician represented to the emergency department with increasing headache, confusion, neck stiffness, subjective fevers and distorted hearing 2 days after diagnosis of viral infection at an outside emergency department.Diagnosis of was made from blood cultures and lumbar puncture. Intravenous ceftriaxone was administered for 21 days. Read More

Vet Microbiol 2022 Jun 4;269:109428. Epub 2022 Apr 4.

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:

The association between changes in the respiratory microbiota and Bovine Respiratory Disease (BRD) in dairy calves is not well understood. We investigated characteristics of the nasopharyngeal (NP) microbiota associated with BRD following Pasteurella multocida infection. We also evaluated the effect of ampicillin on the respiratory microbiota. Read More

Porcine Health Manag 2022 Apr 12;8(1):16. Epub 2022 Apr 12.

National Veterinary Institute, SVA, 751 89, Uppsala, Sweden.

Background: An outdoor pig herd was affected by severe respiratory disease in one out of three pastures. At necropsy, Mycoplasma hyopneumoniae and Pasteurella multocida were detected in the lungs, as well as the lung worm Metastrongylus apri. The life cycle of Metastrongylus spp. Read More

Cureus 2022 Mar 8;14(3):e22950. Epub 2022 Mar 8.

Critical Care, University of Texas Health Science Center at San Antonio, San Antonio, USA.

is a small Gram-negative organism that usually causes a localized infection after exposure to cat or dog scratches, bites, or licking wounds. Invasive infections, such as bacteremia and endocarditis, are very rare yet serious conditions that are associated with high morbidity and mortality, particularly in patients with major comorbidities. Here, we report a case of a 47-year-old male who presented to the hospital with altered mental status two weeks after a fall and was found to have a subarachnoid hemorrhage. Read More

Microbiol Spectr 2022 04 11;10(2):e0019522. Epub 2022 Apr 11.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash Universitygrid.1002.3, Melbourne, Victoria, Australia.

Pasteurella multocida is a Gram-negative capsulated bacterium responsible for a range of diseases that cause severe morbidity and mortality in livestock animals. The hyaluronic acid (HA) capsule produced by P. multocida serogroup A strains is a critical virulence factor. Read More

Vet World 2022 Feb 10;15(2):275-280. Epub 2022 Feb 10.

Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background And Aim: B:2 is the causative agent of hemorrhagic septicemia (HS) in buffalo and cattle. Buffaloes are known to be more susceptible to HS than cattle, but the reason for this remains unknown. This study aimed to compare the efficiency with which buffalo and cattle macrophages can kill B:2. Read More

Front Microbiol 2022 8;13:849482. Epub 2022 Mar 8.

Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, China.

is a zoonotic pathogen causing respiratory infection in different animal species such as cattle, sheep, pigs, chickens and humans. Inflammasome is a complex assembled by multiple proteins in the cytoplasm and plays an important role in the host defense against microbial infection. Bovine type A (PmCQ2) infection induces NLRP3 inflammasome activation and IL-1β secretion, but the mechanism of PmCQ2-induced activation of NLRP3 inflammasome is still unknown. Read More

Gene 2022 Jun 24;826:146452. Epub 2022 Mar 24.

ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru 560064, Karnataka, India. Electronic address:

Pasteurella multocida, a Gram-negative bacterium with ubiquitous nature, is known to affect wide range of host species worldwide with varied clinical manifestations including haemorrhagic septicaemia (HS) in bovines. Although, HS causing P. multocida strains were identified and characterized by conventional tools and PCR assays, diverse strains are indistinguishable by these tools in the face of disease outbreaks. Read More

Pathogens 2022 Mar 7;11(3). Epub 2022 Mar 7.

Bacterial Disease Division, Animal and Plant Quarantine Agency, 177 Hyeksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, Korea.

Bacterial infections are a significant cause of illness and death in different animals. However, these bacterial infections could be a source of human disease or illness if these pathogenic bacteria are present in companion animals. This study aimed to investigate the prevalence of pathogenic bacteria associated with different site infections in cats in the Republic of Korea. Read More

Animals (Basel) 2022 Mar 11;12(6). Epub 2022 Mar 11.

Department of Clinical Medicine and Surgery, Faculty of Veterinary Science, University of Agriculture, Faisalabad 38000, Pakistan.

Hemorrhagic septicemia (HS) and mastitis caused by , and are important ailments of the dairy industry especially in South Asia. The present study evaluates the efficacy of a locally prepared hemorrhagic septicemia (HS) and mastitis combined vaccine. To this end, a total of 70 HS, and -free lactating (early stage of lactation) buffaloes (n = 45) and cows (n = 25), and 50 lactating (early stage of lactation) cows (n = 25) and buffaloes (n = 25) positive for / were subjected to two doses of HS-mastitis combined vaccine with an interval of 21 days. Read More

J Bacteriol 2022 04 24;204(4):e0059221. Epub 2022 Mar 24.

Department of Microbiology, Infection Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

The Gram-negative pathogen Pasteurella multocida is the causative agent of many important animal diseases. While a number of P. multocida virulence factors have been identified, very little is known about how gene expression and protein production is regulated in this organism. Read More

J Anesth 2022 Jun 23;36(3):428-431. Epub 2022 Mar 23.

Division of Intensive Care Medicine, Department of Research and Development Center for New Medical Frontiers, Kitasato University, School of Medicine, 1-15-1 Kitasato Minami-ku, Sagamihara City, Kanagawa, 252-0375, Japan.

Pasteurella is a gram-negative coccobacillus that is commonly transmitted through cat and dog bites and causes various diseases in humans. In the present case, kissing an animal caused Pasteurella multocida infection, leading to sepsis and cardiogenic shock. We used venoarterial extracorporeal membrane oxygenation (VA-ECMO) to support the cardiovascular system until recovery. Read More

Vet Res 2022 Mar 18;53(1):20. Epub 2022 Mar 18.

School of Agricultural and Veterinarian Sciences, São Paulo State University (Unesp), Jaboticabal, Brazil.

Mycoplasma (M.) hyopneumoniae interacts with the respiratory microbiota and facilitates colonization of other pathogens. The present study investigated the pulmonary and nasal microbiota of M. Read More

Microb Genom 2022 03;8(3)

Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.

Fowl cholera caused by has re-emerged in Australian poultry production since the increasing adoption of free-range production systems. Currently, autogenous killed whole-cell vaccines prepared from the isolates previously obtained from each farm are the main preventative measures used. In this study, we use whole-genome sequencing and phylogenomic analysis to investigate outbreak dynamics, as well as monitoring and comparing the variations in the lipopolysaccharide (LPS) outer core biosynthesis loci of the outbreak and vaccine strains. Read More

Vet Res 2022 Mar 2;53(1):17. Epub 2022 Mar 2.

Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.

Pasteurella multocida infection frequently causes fowl cholera outbreaks, leading to huge economic losses to the poultry industry worldwide. This study developed a novel live attenuated P. multocida vaccine strain for ducks named PMZ2 with deletion of the gatA gene and first four bases of the hptE gene, both of which are required for the synthesis of the lipopolysaccharide (LPS) outer core. Read More