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Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand; Omics Center for Agriculture, Bioresources, Food, and Health, Faculty of Science, Kasetsart University (OmiKU), Bangkok, 10900, Thailand. Electronic address:

Pasteurella multocida causes respiratory infectious diseases in a multitude of birds and mammals. A number of virulence-associated genes were reported across different strains of P. multocida, including those involved in the iron transport and metabolism. Read More

Trop Anim Health Prod 2018 Dec 10. Epub 2018 Dec 10.

Department of Basic Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, Jilin, China.

Pasteurella multocida (P. multocida) is an important pathogen that causes bovine respiratory disease (BRD) in China and other countries. To investigate the antimicrobial susceptibility of P. Read More

Microbiol Resour Announc 2018 Sep 6;7(9). Epub 2018 Sep 6.

Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.

Here, we report the first genome sequence of Pasteurella multocida BAUTB2 isolated from a buffalo that died from hemorrhagic septicemia in Rajshahi, Bangladesh. Using Illumina HiSeq technology, the BAUTB2 genome length was determined to be 2,439,149 bp, with 40.8% GC content, 2,307 coding sequences (CDS), 6 rRNAs, 51 tRNAs, and 4 noncoding RNAs (ncRNAs). Read More

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.

Pasteurella multocida is an animal-associated Gram-negative member of the Pasteurellaceae family. It is an opportunistic pathogen and is one of the principal bacterial species contributing to bovine respiratory disease complex (BRDC) in feedlot cattle. We present 16 closed genome sequences and antibiograms of isolates cultured from calves exhibiting clinical signs of BRDC and from control calves not showing signs of BRDC. Read More

Microb Pathog 2018 Dec 7;127:202-207. Epub 2018 Dec 7.

Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, PR China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, 730050, China. Electronic address:

This study assessed the antimicrobial activity of 14-O-[(4,6-Diaminopyrimidine-2-yl) thioacetyl] mutilin (DPTM), a novel pleuromutilin candidate with a substituted pyrimidine moiety, against Pasteurella multocida. Minimum Inhibitory Concentration (MIC), Oxford Cup assay, and time-kill experiments were used to measure the activity of DPTM against P. multocida serotype A in vitro. Read More

BMC Microbiol 2018 Dec 5;18(1):205. Epub 2018 Dec 5.

National Veterinary Institute, P.O. Box 19, Bishoftu, Ethiopia.

Background: Mannheimia haemolytica has been recognized as the principal cause of pneumonic pasteurellosis in sheep and goats. It is one of the important diseases of small ruminants in Ethiopia. While annual vaccination using a monovalent vaccine (inactivated Pasteurella multocida biotype A) is common, respiratory diseases are still reported in various parts of Ethiopia. Read More

Respir Med Case Rep 2019 9;26:31-34. Epub 2018 Nov 9.

Department of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

, which colonizes upper respiratory and digestive tracts, is a leading cause of respiratory diseases in many host species. Here, we describe a case of pneumonia with hemoptysis. A 72-year-old female diagnosed with bronchiectasis with a 36-year history presented with a worsened infiltrative and granular shadow in the lower right lobe and lingular segment. Read More

Can Vet J 2018 Oct;59(10):1099-1104

Department of Health Management (Awosile, Heider, Saab, McClure), Diagnostic Services (Saab), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue Charlottetown, Prince Edward Island C1A 4P3.

Diagnostic laboratory antimicrobial susceptibility data for bacteria isolated from clinical samples of cattle, sheep, and goats from 1994 to 2013 were evaluated retrospectively. Among bacteria from bovine mastitis, and were the most commonly isolated organisms. and were commonly isolated from the respiratory tract, while isolates were frequently recovered from the intestinal tract. Read More

Bioprocess Biosyst Eng 2018 Nov 27. Epub 2018 Nov 27.

Bioprocessing and Biomanufacturing Research Centre, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

Pasteurella multocida serotype B:2 is the causative agent of haemorrhagic septicaemia, a fatal disease in cattle and buffaloes. For use as a vaccine in the treatment of HS disease, an efficient cultivation of attenuated gdhA derivative P. multocida B:2 (mutant) for mass production of viable cells is required. Read More

Adv Perit Dial 2018 Nov;34(2018):50-52

From: University of Missouri, Division of Nephrology, Columbia, Missouri, U.S.A.

A 67-year-old white man with a history of end-stage renal disease receiving peritoneal dialysis (PD) presented with acute onset of vomiting, chills, and abdominal pain. He was diagnosed with PD-associated peritonitis secondary to Pasteurella. After failure of 3 weeks of antibiotic treatment, catheter loss occurred. Read More

J Infect Public Health 2018 Nov 23. Epub 2018 Nov 23.

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Introduction: Nanoparticles (NPs) have become very important owing to their various uses. In this research, an environmentally friendly biological technique was used to synthesize silver nanoparticles with Coriandrum sativum L. The objective of this research to use the source for the fabrication of silver NPs from C. Read More

R Soc Open Sci 2018 Oct 10;5(10):181068. Epub 2018 Oct 10.

Department of Biology, University of Nevada, Reno, NV 89557, USA.

Diverse bacterial communities are found on every surface of macro-organisms, and they play important roles in maintaining normal physiological functions in their hosts. While the study of microbiomes has expanded with the influx of data enabled by recent technological advances, microbiome research in reptiles lags behind other organisms. We sequenced the nasal microbiomes in a sample of four North American tortoise species, and we found differing community compositions among tortoise species and sampling sites, with higher richness and diversity in Texas and Sonoran desert tortoises. Read More

Otolaryngol Pol 2018 06;72(5):37-44

BağcılarTraining and Research Hospital, Department of Otorhinolaryngology - Head and Neck Surgery, Istanbul, Turkey.

Introduction: Atrophic rhinitis (AR) is a disease characterized by atrophy of the mucosa, submucosa, bone tissue due to an unknown cause and excessive nasal cavity enlargement. The disease still has no complete treatment, and the treatment of the functional loss of atrophic cells in AR is still a matter to be investigated. Ozone (O3) therapy has been shown to enhance cell metabolism, angiogenesis, fibroblast activity, and collagen synthesis. Read More

Am J Vet Res 2018 Dec;79(12):1268-1276

OBJECTIVE To determine whether target values for pharmacokinetic-pharmacodynamic (PK-PD) indices against selected canine pathogens were achievable for pradofloxacin in various canine fluids and leukocytes. ANIMALS 8 healthy adult hounds (experiments 1 and 2) and 6 healthy adult dogs (experiment 3). PROCEDURES In 3 experiments, pradofloxacin (3, 6, or 12 mg/kg) and enrofloxacin (5 or 10 mg/kg) were orally administered once a day for 5 days, and blood, interstitial fluid (ISF), and other fluid samples were collected at various points. Read More

Biochem Biophys Res Commun 2018 Dec 16;507(1-4):420-425. Epub 2018 Nov 16.

School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. Electronic address:

Background: Antibiotics and none-steroidal anti-inflammatory drugs are often taken orally to treat human diseases. The use of these drugs adversely could affect the natural oral microbiota composition and oral immune system. In the meanwhile, it may break the original balance of oral micro-ecosystem. Read More

J Vet Pharmacol Ther 2018 Nov 8. Epub 2018 Nov 8.

Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.

To explore the in vivo antimicrobial activity of cefquinome against Pasteurella multocida in piglets, a piglet tissue cage infection model was used in this study. After the population of P. multocida reached 10  CFU/mL in a tissue cage, piglets received an intramuscular administration of cefquinome at 0. Read More

Front Microbiol 2018 23;9:2489. Epub 2018 Oct 23.

Section of Paediatrics, Department of Medicine, Imperial College London, London, United Kingdom.

Evidence of plasmids carrying the tetracycline resistance gene, (B), was found in the previously reported whole genome sequences of 14 United Kingdom, and 4 Brazilian, isolates of Isolation and sequencing of selected plasmids, combined with comparative sequence analysis, indicated that the four Brazilian isolates all harbor plasmids that are nearly identical to pB1001, a plasmid previously found in isolates from Spain. Of the United Kingdom isolates, 13/14 harbor plasmids that are (almost) identical to pTetHS016 from . The remaining United Kingdom isolate, MIDG3362, harbors a 12666 bp plasmid that shares extensive regions of similarity with pOV from (which carries , , and genes), as well as with pTetHS016. Read More

Res Vet Sci 2018 Dec 22;121:111-115. Epub 2018 Oct 22.

Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.

The single dose pharmacokinetics (PK) of marbofloxacin was compared with repeated intravenous (IV) administrations in six healthy goats at the dose rate of 2 mg/kg body weight at 24 h interval for 5 days. Blood samples were collected at times: 5, 15, 30 min and 1, 2, 4, 6, 9, 12, 24, 36, 48 and 72 h post drug administration. Plasma drug concentrations were determined by High Performance Liquid Chromatography and concentration-time data were subjected to non-compartment analysis. Read More

Arch Razi Inst 2017 Sep 23;72(3):165-171. Epub 2016 Oct 23.

Department of Central Laboratory, Razi Vaccine and Serum Research Institute, Agricultural Research, Education, and Extension Organization,Karaj, Iran.

Pasteurella multocida isa gram-negative bacterial pathogen that is causative agent of a wide range of diseases in many animal species and humans. Lipopolysaccharides (LPS) are an important virulence factor, minor changes to structure of which can exert dramatic effects on pathogenicity of P. multocida in its host. Read More

J Biol Chem 2018 Oct 12. Epub 2018 Oct 12.

Institute for Stem Cell Biology and Regenerative Medicine, India.

The primary role of bacterial periplasmic binding proteins is sequestration of essential metabolites present at a low concentration in the periplasm and making them available for active transporters that transfer these ligands into the bacterial cell. The periplasmic binding proteins(SiaP) from the tripartite ATP-independent periplasmic (TRAP) transport system that transports mammalian host-derived sialic acids, have been well studied from different pathogenic bacteria, including , , , and SiaPs bind the sialic acid N-acetylneuraminic acid (Neu5Ac) with nanomolar affinity by forming electrostatic and hydrogen bonding interactions. Here, we report the crystal structure of a periplasmic binding protein (SatA) of the ATP-binding cassette (ABC) transport system from the pathogenic bacterium The structure of Hd-SatA in the native form and sialic acid-bound forms (with Neu5Ac and N-glycolylneuraminic acid [Neu5Gc]), determined to 2. Read More

J Fish Dis 2018 Oct 12. Epub 2018 Oct 12.

Department of Biological Sciences, University of Bergen, Bergen, Norway.

The incidence of disease caused by Pasteurella sp. in farmed lumpsuckers in Norway has been steadily increasing in recent years, causing significant economic losses and fish welfare issues. The disease affects all life stages, both in hatcheries and after release into salmon cages. Read More

J Vet Med Sci 2018 Dec 8;80(12):1861-1866. Epub 2018 Oct 8.

Fujian Provincial Key Laboratory for Avian Diseases Control and Prevention/Fujian Animal Diseases Control Technology Development Center, Institute of Animal Husbandry and Veterinary Medicine of Fujian Academy of Agricultural Sciences, Fuzhou 350013, People's Republic of China.

Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV) have both been found to cause high mortality and morbidity in Muscovy ducklings. Specific detection is often rife with false positives due to high identity at the genomic nucleotide level and antigenic similarity between MDPVs and GPVs. In this study, significantly variable regions were found, via non-structural (NS) comparison, between MDPV and GPV NS genes; however, NS genes were conserved within the MDPV and GPV groups. Read More

Avian Pathol 2018 Oct 7:1-8. Epub 2018 Oct 7.

a Faculty of Veterinary Medicine , Chiang Mai University , Muang, Chiang Mai , Thailand.

A capsule-defective mutant strain PBA129 of Pasteurella multocida was constructed by electroporation of phagemid containing the coding region of the antisense RNA of the ompH gene into the wild type strain X-73 (serovar A:1) of P. multocida. The pathogenicity and protective potency of the mutant against homologous and heterologous challenge in mice and chickens were characterized. Read More

Infect Dis Rep 2018 Sep 5;10(2):7632. Epub 2018 Sep 5.

Department of Human Pathology of the Adult and the Developmental Age "G. Barresi", Unit of Infectious Diseases, University of Messina, Italy.

species reside in the gastrointestinal tract of many animals, especially in pets such as cats or dogs. Zoonotic transmission of to human is documented. We describe a case of meningitis in a 66-year-old woman with positive blood culture for Meningitis caused by zoonosis agents is a rare event, but it should be suspected in patients that have recreational or professional exposure to animals. Read More

Pediatr Rev 2018 Oct;39(10):490-500

Department of Pediatrics, Sanford Children's Hospital, Sioux Falls, SD.

In the United States, nearly 56% of households owned a pet in 2011 according to the by the American Veterinary Medical Association. The survey also reports that approximately 70 million dogs and 74 million cats lived in households in the United States during the same year. (1)Human and animal bites are a frequent cause of primary care and emergency department visits for children. Read More

J Vet Pharmacol Ther 2018 Sep 28. Epub 2018 Sep 28.

Department of Comparative Biomedical Sciences, Royal Veterinary College, Hatfield, Herts, UK.

For clinical isolates of bovine Mannheimia haemolytica and Pasteurella multocida, this study reports minimum inhibitory concentration (MIC) differences for tetracycline, oxytetracycline and doxycycline between cation-adjusted Mueller-Hinton broth (CAMHB), foetal bovine serum (FBS) and Roswell Park Memorial Institute (RPMI) medium. MICs were determined according to CLSI standards and additionally using five overlapping sets of twofold dilutions. Matrix effect: (a) free drug MICs and minimum bactericidal concentrations (MBC) for all drugs were significantly higher in FBS than in CAMHB for both pathogens (p < 0. Read More

Aust Vet J 2018 Oct;96(10):390-394

Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, EcoSciences Precinct, Dutton Park, Queensland, Australia.

Objective: To investigate the genotype and diversity of Pasteurella multocida present in pig herds and to determine the extent of overlap with isolates from poultry flocks in Australia.

Methods: A total of 43 isolates from pigs from different farms and regions of Australia were used in this study. A diverse collection of 41 poultry isolates, with 31 being previously characterised, was also used. Read More

Aust Vet J 2018 10;96(10):367-368

Infect Immun 2018 Oct 21;86(10). Epub 2018 Sep 21.

Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

J Vet Diagn Invest 2018 Nov 21;30(6):837-847. Epub 2018 Sep 21.

School of Veterinary Medicine and Biomedical Sciences (Loy, Leger), University of Nebraska-Lincoln, Lincoln, NE.

Bovine respiratory disease complex (BRDC) is one of the most significant diseases of cattle. Bacterial pathogens involved in BRDC include Mannheimia haemolytica, Mycoplasma bovis, Histophilus somni, and Pasteurella multocida. We developed and evaluated a multiplexed real-time hydrolysis probe (rtPCR) assay using block-based Peltier and rotary-based thermocycling on lung tissue, nasal swabs, and deep nasopharyngeal swabs. Read More

Sci Rep 2018 Sep 11;8(1):13599. Epub 2018 Sep 11.

Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Pasteurella multocida is notorious for its role as an opportunistic pathogen in infectious bronchopneumonia, the economically most important disease facing cattle industry and leading indication for antimicrobial therapy. To rationalize antimicrobial use, avoiding imprudent use of highly and critically important antimicrobials for human medicine, availability of a rapid antimicrobial susceptibility test is crucial. The objective of the present study was to design a MALDI Biotyper antibiotic susceptibility test rapid assay (MBT-ASTRA) procedure for tetracycline resistance detection in P. Read More

J Infect Chemother 2018 Sep 5. Epub 2018 Sep 5.

Division of Infection Control and Prevention, Osaka University Hospital, Japan.

Pasteurella multocida, a zoonotic pathogen in humans, is known to be associated with skin and soft tissue infections following animal bites, but rarely causes visceral infections. We report a case of P. multocida-associated multiple intrapelvic abscesses in a young woman with uterine cervical cancer. Read More

J Vet Pharmacol Ther 2018 Dec 4;41(6):912-918. Epub 2018 Sep 4.

College of Veterinary Medicine, Yangzhou University, Yangzhou, China.

Pasteurella multocida (P. multocida) infection causes substantial economic loss in the duck industry. Danofloxacin, a fluoroquinolone solely used in animals, shows good antibacterial activity against P. Read More

Vet World 2018 Jul 29;11(7):1006-1014. Epub 2018 Jul 29.

Department of Microbiology and Immunology, Veterinary Division, National Research Center, Dokki, Egypt.

Aim: This study aimed to create rapid characterization and genotyping of (PM) protocol using modern molecular biology techniques.

Materials And Methods: Thirty bacterial isolates were characterized by capsular and somatic identification using conventional procedure followed by multiplex polymerase chain reaction (PCR), restriction endonucleases analysis (REA), and finally confirmed by sequence analysis. Two local vaccine strains and two field isolates were identified as PM Type A and B. Read More

BMC Infect Dis 2018 Aug 23;18(1):420. Epub 2018 Aug 23.

Division of infectious diseases and global public health, University of California San Diego, San Diego, USA.

Background: There are as many as 300,000 visits to the emergency department in the USA with animal bites every year. The most common infection after cat or dog bite is with Pasteurella Multocida. Many people infected will also have long-term central venous access for dialysis or for other reasons. Read More

BMC Vet Res 2018 Aug 22;14(1):244. Epub 2018 Aug 22.

Embrapa Suinos e Aves, P.O. Box 121, Concórdia, Santa Catarina, 89700-000, Brazil.

Background: Pasteurella multocida type A (PmA) is considered a secondary agent of pneumonia in pigs. The role of PmA as a primary pathogen was investigated by challenging pigs with eight field strains isolated from pneumonia and serositis in six Brazilian states. Eight groups of eight pigs each were intranasally inoculated with different strains of PmA (1. Read More

Front Microbiol 2018 7;9:1678. Epub 2018 Aug 7.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Phage PHB02 specifically infects capsular serogroup A strains. In this study, we found that capsule deletion mutants were not lysed by PHB02, suggesting that the capsule of serogroup A strains might be the primary receptor. Based on sequence analysis, a gene encoding a phage-associated putative depolymerase was identified. Read More

Vet Rec Open 2018 31;5(1):e000293. Epub 2018 Jul 31.

Bacterial Disease Division, Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea.

is one of the significant causes of respiratory infection outbreaks in the Korean pig industry. Although antimicrobial treatment is an effective strategy for controlling respiratory diseases, limited information is available regarding the antimicrobial susceptibility of the pathogens infecting Korean pigs. Therefore, in this study, we evaluated the antimicrobial resistance of against widely used antimicrobials in order to enable the selection of appropriate drugs and to evaluate any trends in resistance. Read More

IDCases 2018 24;13:e00429. Epub 2018 Jul 24.

University of Florida, Department of Medicine, Division of Infectious Diseases and Global Medicine, 1600 Southwest Archer Road, Gainesville, 32610 FL, United States.

Can Vet J 2018 Aug;59(8):885-893

Department of Health Management (Awosile, McClure, Saab, Heider), Diagnostic Services (Saab), Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island.

Antimicrobial susceptibility patterns and trends in bacteria isolated from cats and dogs were determined from diagnostic laboratory data from the Atlantic Veterinary College Diagnostic Services Bacteriology Laboratory over a 20-year period. Clinical samples were most commonly from the urinary tract and the ear. spp. Read More

Toxins (Basel) 2018 Aug 13;10(8). Epub 2018 Aug 13.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany.

toxin (PMT) causes progressive atrophic rhinitis with severe turbinate bone degradation in pigs. It has been reported that the toxin deamidates and activates heterotrimeric G proteins, resulting in increased differentiation of osteoclasts and blockade of osteoblast differentiation. So far, the action of PMT on osteocytes, which is the most abundant cell type in bone tissue, is not known. Read More

J Virol Methods 2018 11 10;261:51-62. Epub 2018 Aug 10.

Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada; Canadian Food Inspection Agency, Lethbridge Laboratory, Lethbridge, AB, Canada. Electronic address:

Respiratory and enteric diseases continue to be two major causes of economic losses to the cattle industry worldwide. Despite their multifactorial etiology, the currently available diagnostic tests for bovine respiratory disease complex (BRDC) and bovine enteric disease (BED) are single-pathogen-tests. DNA microarray when combined with multiplex polymerase chain reaction (PCR) is a powerful tool in detection and differentiation of multiple pathogens in a single sample. Read More

Front Pharmacol 2018 26;9:765. Epub 2018 Jul 26.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

(PM) can invade the upper respiratory tract of the body and cause death and high morbidity. Tildipirosin, a new 16-membered-ring macrolide antimicrobial, has been recommended for the treatment of respiratory diseases. The objective of this research was to improve the dose regimes of tildipirosin to PM for reducing the macrolides resistance development with the pharmacokinetic/pharmacodynamic (PK/PD) modeling approach and to establish an alternate cutoff for tildipirosin against PM. Read More

J Am Assoc Lab Anim Sci 2018 Sep 9;57(5):477-482. Epub 2018 Aug 9.

Georgetown University, Division of Comparative Medicine, Washington, DC;, Email:

Testing sentinel animals exposed to soiled bedding from colony animals is the most common method used for health monitoring in rodent facilities. Although environmental sampling is being explored-and, in many cases, has been implemented-as an alternative, exhaust plenum sampling is not effective for all ventilated rack designs. This study evaluated PCR testing of filter paper from sentinel cages on ventilated racks. Read More

Vet Microbiol 2018 Aug 17;222:114-123. Epub 2018 Jul 17.

Virginia-Maryland College of Veterinary Medicine, Department of Biomedical Sciences & Pathobiology, Virginia Tech, Blacksburg, VA, 24061, United States; Virginia Tech Carilion School of Medicine, Virginia Tech, Blacksburg, VA, 24061, United States. Electronic address:

Pasteurella multocida is the causative agent of avian cholera, an important economic and ecological disease that can present as a peracute, acute, chronic, or asymptomatic infection. Acute avian cholera is associated with encapsulated P. multocida, while chronic and asymptomatic cases of avian cholera may be associated with capsule-deficient P. Read More

Arch Pharm (Weinheim) 2018 Sep 29;351(9):e1800155. Epub 2018 Jul 29.

Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, China.

Pleuromutilin derivatives 4a-h, 5a-g, and 6a-d were synthesized and characterized by IR, H NMR, and C NMR. All synthetic compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus (ATCC 25923), methicillin-resistant S. aureus (MRSA, ATCC 43300), Pasteurella multocida (CVCC 408), Escherichia coli (ATCC 25922), and Salmonella typhimurium (ATCC 14028). Read More

Oxid Med Cell Longev 2018 27;2018:1780956. Epub 2018 Jun 27.

Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.

The present study investigated the efficacy of allicin as an antibacterial, anti-inflammatory, antioxidant, and immunostimulant agent in reducing the severity of () type B infection in rabbits. Fifty New Zealand rabbits, 5 weeks old, were divided equally into five groups. Except for group 1, all groups were intranasally infected with type B (2 × 10 colony forming units/ml/rabbit). Read More

Front Vet Sci 2018 10;5:153. Epub 2018 Jul 10.

Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.

The objectives of this study were to determine antimicrobial resistance and metal tolerance, and identify associated genes and mobile genetic elements in clinical strains of isolated from feedlot cattle in Alberta during years 2012-2016 (contemporary isolates, = 63) and years 1980-1990 (historical isolates, = 31). Comparison of antimicrobial resistance (AMR) showed a significant increase in resistance among contemporary isolates compared to historical isolates ( < 0.001). Read More

Cell Discov 2018 17;4:35. Epub 2018 Jul 17.

State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.

Various bacteria can ferment vitamin C (l-ascorbate) under anaerobic conditions via the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS system is composed of two soluble energy-coupling proteins (EI and HPr) and an enzyme II complex (EIIA, EIIB, and EIIC) for the anaerobic uptake of ascorbate and its phosphorylation to l-ascorbate 6-phosphate in vivo. Crystal structures of the ascorbate-bound EIIC component from are available in outward-open and occluded conformations, suggesting a possible elevator mechanism of membrane transport. Read More

BMC Res Notes 2018 Jul 17;11(1):485. Epub 2018 Jul 17.

Shire-Maytsebri Agricultural Research Center, P.O. Box 81, Shire, Ethiopia.

Objectives: A cross-sectional study was employed with the aim to explore the serological status of goats; we evaluated the presence of serum antibodies of the circulating serotypes of the genus Pasteurella. A total of 124 serum samples were collected from randomly selected goats and subsequently serotyped using indirect haemagglutination test.

Results: In the current study, the overall prevalence of pasteurellosis in goats was 31. Read More