23,970 results match your criteria Partial Epilepsies


A Study among the Genotype, Functional Alternations, and Phenotype of 9 SCN1A Mutations in Epilepsy Patients.

Sci Rep 2020 Jun 24;10(1):10288. Epub 2020 Jun 24.

Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, Bratislava, 842 15, Slovakia.

Mutations in the voltage-gated sodium channel Na1.1 (SCN1A) are linked to various epileptic phenotypes with different severities, however, the consequences of newly identified SCN1A variants on patient phenotype is uncertain so far. The functional impact of nine SCN1A variants, including five novel variants identified in this study, was studied using whole-cell patch-clamp recordings measurement of mutant Na1. Read More

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http://dx.doi.org/10.1038/s41598-020-67215-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314844PMC

Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options.

Pharmacol Rev 2020 Jul;72(3):606-638

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany (W.L.); Center for Systems Neuroscience, Hannover, Germany (W.L.); Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University, Munich, Germany (H.P.); Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom (S.S); and Department of Neuroscience, Mario Negri Institute for Pharmacological Research Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy (A.V.).

Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide. Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of epileptic seizures, about one-third of patients with epilepsy have seizures refractory to pharmacotherapy. Patients with such drug-resistant epilepsy (DRE) have increased risks of premature death, injuries, psychosocial dysfunction, and a reduced quality of life, so development of more effective therapies is an urgent clinical need. Read More

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http://dx.doi.org/10.1124/pr.120.019539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300324PMC

Focal status epilepticus as unique clinical feature of COVID-19: A case report.

Seizure 2020 May 21;78:109-112. Epub 2020 Apr 21.

Neurologia, Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; Neurologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

SARS-CoV-2, a novel zoonotic coronavirus, is currently spreading all over the world, causing a pandemic disease defined coronavirus disease 2019 (COVID-19). The spectrum of COVID-19 ranges from asymptomatic or mild infection to rapidly progressive, acute respiratory distress syndrome and death [1].To the best of our knowledge, status epilepticus has never been described as initial presentation of COVID-19. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172719PMC

SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model.

Braz J Med Biol Res 2020 6;53(4):e9175. Epub 2020 Apr 6.

Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Read More

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http://dx.doi.org/10.1590/1414-431X20199175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162585PMC

Vitamin D Status in Epileptic Children on Valproic Acid; a Case-Control Study.

Arch Acad Emerg Med 2020 27;8(1):e13. Epub 2020 Feb 27.

Raparin Pediatric Hospital, Hawler Medical University, College of Medicine, Erbil, Iraq.

Introduction: Much attention has been paid to the association between valproic acid treatment and bone health. The objective of this study is to compare the serum vitamin D3 level in the epileptic children under valproic acid treatment with the healthy control group.

Methods: A case-control study has been carried out to compare vitamin D3 levels in 50 epileptic children who were treated with valproic acid with 50 healthy children selected from children visiting the hospital for routine checkup as control group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130439PMC
February 2020

Eight-Year Experience With 3-T Intraoperative MRI Integration in Focal Pediatric Epilepsy Surgery: Impact on Extent of Resection, Residual Volumes, and Seizure Outcomes.

AJR Am J Roentgenol 2020 06 24;214(6):1343-1351. Epub 2020 Mar 24.

Department of Diagnostic Imaging, Montreal Children's Hospital, McGill University, 1001 Decarie Blvd, Rm B02.7005, Montreal, QC H4A 3J1, Canada.

The purpose of this study was to investigate the influence of 3-T intraoperative MRI (ioMRI) on the extent of resection of pediatric focal epileptogenic lesions, residual lesion volumes, and postoperative seizure outcomes. All surgical procedures for focal epilepsy from 2003 to 2017 were retrospectively reviewed. Patients were divided into two groups: those who underwent ioMRI and those who did not. Read More

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http://dx.doi.org/10.2214/AJR.19.22336DOI Listing

New Treatment for Partial-Onset Seizures in Adults.

Am J Nurs 2020 03;120(3):24-25

Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch:

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http://dx.doi.org/10.1097/01.NAJ.0000656316.30694.43DOI Listing

A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy.

Nat Commun 2020 02 17;11(1):923. Epub 2020 Feb 17.

Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of SNr parvalbumin (PV) GABAergic neurons amplifies seizure activities in kindling- and kainic acid-induced TLE models, whereas selective inhibition of these neurons alleviates seizure activities. The severity of seizures is bidirectionally regulated by optogenetic manipulation of SNr PV fibers projecting to the parafascicular nucleus (PF). Read More

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http://dx.doi.org/10.1038/s41467-020-14648-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026152PMC
February 2020

[microsurgery 'burr hole' for intracranial tumors and mesial temporal lobe epilepsy].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(6):44-57

Burdenko Neurosurgical Center, Moscow, Russia.

Purpose: In recent years, neurosurgery has been characterized by a clear tendency towards the development of minimally invasive and less traumatic surgical approaches. To minimize the degree of injury to the brain tissue, we have proposed burr hole-based microsurgical approaches.

Material And Methods: In the period between February 2016 and February 2019, more than 500 microsurgical interventions were performed through a 14 mm burr hole using a technique that we called burr-hole microneurosurgery; to date, 200 of these have been analyzed. Read More

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http://dx.doi.org/10.17116/neiro20198306144DOI Listing

Accelerated long-term forgetting after amygdalohippocampectomy in temporal lobe epilepsy.

J Clin Neurosci 2020 Feb 16;72:43-49. Epub 2020 Jan 16.

REMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.

Aim Of The Study: Temporal lobe epilepsy (TLE) has been associated with the phenomenon of accelerated long-term forgetting (ALF). In this study, we aimed to demonstrate the effect of surgery on the ALF phenomena thus contributing to potential explanation of the causal mechanism.

Materials And Methods: We evaluated 51 patients with TLE related to hippocampal sclerosis who had amygdalohippocampectomy and had remained seizure-free after surgery. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.01.038DOI Listing
February 2020

Evaluating Invasive EEG Implantations with Structural Imaging Data and Functional Scalp EEG Recordings from Epilepsy Patients.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:3866-3869

Seizures in patients with medically refractory epilepsy (MRE) cannot be controlled with drugs. For focal MRE, seizures originate in the epileptogenic zone (EZ), which is the minimum amount of cortex that must be treated to be seizure free. Localizing the EZ is often a laborious process wherein clinicians first inspect scalp EEG recordings during several seizure events, and then formulate an implantation plan for subsequent invasive monitoring. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857241DOI Listing

Effect of Temporal Lobe Epilepsy on Auditory-motor Integration for Vocal Pitch Regulation: Evidence from Brain Functional Network Analysis.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:3849-3853

Temporal lobe epilepsy (TLE) is a medically refractory focal epilepsy associated with structural deficits. Considerable evidence has revealed that patients with TLE also exhibit deficits in functional connectivity. According to previous research, patients with TLE exhibited decreased performance in speech sound perception and auditory-motor integration for voice control, which might be related to the compromised brain network connectivity. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856902DOI Listing

Ongoing intracortical neural activity predicts upcoming interictal epileptiform discharges in human epilepsy.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:2386-2391

Interictal epileptiform discharges (IEDs) are a hallmark of focal epilepsies. Most previous studies have focused on whether IED events increase seizure likelihood or, on the contrary, act as a protective mechanism. Here, we study instead whether IED events themselves can be predicted based on measured ongoing neural activity. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857513DOI Listing

Evolution of Graph Theory in Dynamic Functional Connectivity for Lateralization of Temporal Lobe Epilepsy.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:628-631

Resting-state functional magnetic resonance imaging (rsfMRI) has described the functional architecture of the human brain in the absence of any task or stimulus. Since the functional connectivity (FC), has non-stationary nature, it is evidenced to be varying over time. Using dynamic functional connectivity, six graph theoretical characteristics were measured and compared between left and right temporal lobe epilepsy (TLE). Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856717DOI Listing

Clinically Significant Visual Deficits after Laser Interstitial Thermal Therapy for Mesiotemporal Epilepsy.

Stereotact Funct Neurosurg 2019 14;97(5-6):347-355. Epub 2020 Jan 14.

Department of Neurological Surgery, University of Miami, Miami, Florida, USA,

Background: Laser interstitial thermal therapy (LITT) has recently gained popularity as a minimally invasive surgical option for the treatment of mesiotemporal epilepsy (mTLE). Similar to traditional open procedures for epilepsy, the most frequent neurological complications of LITT are visual deficits; however, a critical analysis of these injuries is lacking.

Objectives: To evaluate the visual deficits that occur after LITT for mTLE and their etiology. Read More

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http://dx.doi.org/10.1159/000504856DOI Listing

Cenobamate: First Approval.

Authors:
Susan J Keam

Drugs 2020 Jan;80(1):73-78

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Cenobamate (XCOPRI) is an oral, small molecule neurotherapeutic azole compound that is being developed by SK Life Science Inc. and Arvelle Therapeutics for the treatment of epilepsy. Based on results of two pivotal phase 2 trials, cenobamate was recently approved in the USA for use in the treatment of partial-onset seizures in adult patients. Read More

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http://dx.doi.org/10.1007/s40265-019-01250-6DOI Listing
January 2020

Mystery Case: Parietal lobe epilepsy with ictal manifestation of Gerstmann syndrome.

Neurology 2020 01 13;94(4):e430-e433. Epub 2020 Jan 13.

From the Epilepsy Center (H.M.K., N.T., S.O., K.K.-S., H.K.), Osaka University Hospital; Departments of Neurosurgery (H.M.K., Y.F., N.T., S.O., H.K.) and Pediatrics (K.K.-S.), Osaka University Graduate School of Medicine; and Division of Developmental Neuroscience (K.K.-S.), United Graduate School of Child Development, Osaka University, Suita, Japan.

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http://dx.doi.org/10.1212/WNL.0000000000008841DOI Listing
January 2020

Breakdown of spatial coding and interneuron synchronization in epileptic mice.

Nat Neurosci 2020 02 6;23(2):229-238. Epub 2020 Jan 6.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain unknown. Interneuron death and reorganization during epileptogenesis may disrupt the synchrony of hippocampal inhibition. To test this, we simultaneously recorded from the CA1 and dentate gyrus in pilocarpine-treated epileptic mice with silicon probes during head-fixed virtual navigation. Read More

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http://dx.doi.org/10.1038/s41593-019-0559-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259114PMC
February 2020
16.095 Impact Factor

Ictal multicomponent agraphia in left temporal lobe epilepsy.

Neurology 2020 01;94(1):42-43

From the Departments of Neurology (C.U., G.O.-G., C.P., P.L., U.U.) and Radiology (J.L.), University of Kansas Medical Center, Kansas City.

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http://dx.doi.org/10.1212/WNL.0000000000008705DOI Listing
January 2020

Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis.

PLoS One 2019 30;14(12):e0226575. Epub 2019 Dec 30.

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Background And Aims: Mesial Temporal Lobe Epilepsy is characterized by progressive changes of both neurons and glia, also referred to as epileptogenesis. No curative treatment options, apart from surgery, are available. DNA methylation (DNAm) is a potential upstream mechanism in epileptogenesis and may serve as a novel therapeutic target. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226575PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936816PMC

Applicability and contribution of the new ILAE 2017 classification of epileptic seizures and epilepsies.

Epileptic Disord 2019 Dec;21(6):549-554

Epilepsy Section, Instituto de Neurología, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Uruguay.

The aim of the study was to evaluate the clinical applicability of the 2017 ILAE classification of seizures and epilepsies through the analysis of a sample of 100 outpatients with a diagnosis of epilepsy. All clinical charts were reviewed applying both the 1981/1989 and 2017 classifications of seizures and epilepsies, respectively. For most focal seizures, descriptors were required to include all the relevant clinical information. Read More

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http://dx.doi.org/10.1684/epd.2019.1108DOI Listing
December 2019

Benign Rolandic epilepsy: widespread increases in connectivity in a focal epilepsy syndrome.

Epileptic Disord 2019 Dec;21(6):567-578

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Benign Rolandic epilepsy (benign epilepsy with centrotemporal spikes; recently renamed self-limited epilepsy with centrotemporal spikes) is associated with widespread deficits in cognition and behavior, suggesting abnormalities in networks that extend beyond the centrotemporal region. To assess functional connectivity in children with benign Rolandic epilepsy, we assessed EEG spectral power and coherence during awake and sleep records in 27 children with centrotemporal spikes. Coherence represents the consistency of the phase difference between two EEG signals when compared over time and serves as a measure of synchronization between two EEG signals based mainly on phase consistency. Read More

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http://dx.doi.org/10.1684/epd.2019.1111DOI Listing
December 2019

Ictal asystole with intercurrent cardiopathy: a complex combination leading to delayed diagnosis.

Epileptic Disord 2019 Dec;21(6):598-602

Centre de recherche du Centre Hospitalier de l'Université de Montréal,, Division of Neurology, Centre Hospitalier de l'Université de Montréal.

Ictal asystole is a rare epileptic phenomenon, though usually self-limiting, which has been associated with an increased risk of sudden death in epileptic patients. Although early recognition is desirable, the diagnosis can be delayed until prolonged video-EEG monitoring is completed. We report a case of ictal asystole in a 74-year-old patient with co-morbid cardiac conditions leading to a delay in diagnosis of approximately 10 years. Read More

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http://dx.doi.org/10.1684/epd.2019.1118DOI Listing
December 2019
5 Reads

[Visual field disorder after surgery of temporal lobe epilepsy associated to hippocampus sclerosis].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(5):14-20

Burdenko Neurosurgical Center, Moscow, Russia.

Objective: Assessment of frequency and severity of visual field disorders after neurosurgical operations at patients with pharmacoresistant form of epilepsy in hippocampus sclerosis.

Material And Methods: The study included 48 patients having surgical operations for a pharmacoresistant form of temporal lobe epilepsy due to hippocampus sclerosis. Anterior lobectomy with amygdalohippocampectomy (LE + AHE) was performed in 25 patients; Selective amygdalohippocampectomy (SAHE) was performed in 23 patients. Read More

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http://dx.doi.org/10.17116/neiro20198305114DOI Listing
January 2020

Losigamone add-on therapy for focal epilepsy.

Cochrane Database Syst Rev 2019 12 11;12:CD009324. Epub 2019 Dec 11.

The First Affiliated Hospital, Guangxi Medical University, Department of Neurology, No. 22, Shuang Yong Road, Nanning, China, 530021.

Background: Epilepsy is a common neurologic disorder, affecting approximately 50 million people worldwide; nearly a third of these people have epilepsy that is not well controlled by a single antiepileptic drug (AED) and they usually require treatment with a combination of two or more AEDs. In recent years, many newer AEDs have been investigated as add-on therapy for focal epilepsy; losigamone is one of these drugs and is the focus of this systematic review. This is an update of a Cochrane Review first published in 2012 and updated in 2018. Read More

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http://dx.doi.org/10.1002/14651858.CD009324.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904891PMC
December 2019

Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1.

Mol Brain 2019 12 3;12(1):102. Epub 2019 Dec 3.

Medical Laboratory, Affiliated Hospital, Xuzhou Medical University, No. 99, Huaihai West Road, Xuzhou City, 221002, Jiangsu Province, China.

This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model of TLE was established by intraperitoneal injection of lithium chloride-pilocarpine. These model rats were injected intracerebroventricularly with an miRNA-146a inhibitor and Notch-1 siRNA. Read More

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http://dx.doi.org/10.1186/s13041-019-0523-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892218PMC
December 2019

[Electroclinical characteristics of epilepsy children with midline epileptiform discharges related epileptic negative myoclonus as the first symptom].

Zhonghua Er Ke Za Zhi 2019 Dec;57(12):943-949

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To investigate the electroclinical findings in epilepsy children with epileptic negative myoclonus (ENM) restricted to the lower limb as the first seizure type. Each retrieved electroencephalogram record performed between March 2011 and March 2018 at the Department of Pediatrics of Peking University First Hospital was searched with "midline" . There were 302 records of 175 patients with "benign" or "functional" midline spikes. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.12.009DOI Listing
December 2019

Predictors of Class I epilepsy surgery outcome in tumour-related chronic temporal lobe epilepsy in adults.

Neurol Neurochir Pol 2019 3;53(6):466-475. Epub 2019 Dec 3.

Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland, Banacha 1a, 02-097 Warsaw, Poland.

Objective: Temporal lobe tumours, especially low-grade gliomas and glioneuronal tumours, are common causes of seizures in patients referred for epilepsy surgery. We here present our experience of surgical treatment of patients with intractable chronic epilepsy associated with temporal lobe tumours, focusing on the long-term surgical outcomes and the features associated with better seizure control.

Methods: In this study, we retrospectively analysed 44 consecutive patients from a total of 182 with refractory temporal lobe epilepsy presenting with long-term intractable epilepsy due to a temporal lobe tumour who were surgically treated at our institution between 2005 and 2015 with post-surgical follow-up of at least two years. Read More

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http://dx.doi.org/10.5603/PJNNS.a2019.0061DOI Listing
January 2020

Automatic labeling of the fanning and curving shape of Meyer's loop for epilepsy surgery: an atlas extracted from high-definition fiber tractography.

BMC Neurol 2019 Nov 28;19(1):302. Epub 2019 Nov 28.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xuanwu District, Beijing, 100053, China.

Background: Visual field defects caused by injury to Meyer's loop (ML) are common in patients undergoing anterior temporal lobectomy during epilepsy surgery. Evaluation of the anatomical shapes of the curving, fanning and sharp angles of ML to guide surgeries is important but still challenging for diffusion tensor imaging. We present an advanced diffusion data-based ML atlas and labeling protocol to reproduce anatomical features in individuals within a short time. Read More

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http://dx.doi.org/10.1186/s12883-019-1537-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882219PMC
November 2019

Neuroplasticity in Cholinergic Projections from the Basal Forebrain to the Basolateral Nucleus of the Amygdala in the Kainic Acid Model of Temporal Lobe Epilepsy.

Int J Mol Sci 2019 Nov 13;20(22). Epub 2019 Nov 13.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.

The amygdala is a cerebral region whose function is compromised in temporal lobe epilepsy (TLE). Patients with TLE present cognitive and emotional dysfunctions, of which impairments in recognizing facial expressions have been clearly attributed to amygdala damage. However, damage to the amygdala has been scarcely addressed, with the majority of studies focusing on the hippocampus. Read More

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http://dx.doi.org/10.3390/ijms20225688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887742PMC
November 2019

Localization value of subclinical seizures on scalp video-EEG in epilepsy presurgical evaluation.

Epilepsia 2019 12 21;60(12):2477-2485. Epub 2019 Nov 21.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: To evaluate the localization value and prognostic significance of subclinical seizures (SCSs) on scalp video-electroencephalography monitoring (VEEG) in comparison to clinical seizures (CSs) in patients who had epilepsy surgery.

Methods: We included 123 consecutive patients who had SCSs and CSs during scalp-VEEG evaluation. All patients had subsequent epilepsy surgery and at least 1-year follow-up. Read More

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http://dx.doi.org/10.1111/epi.16383DOI Listing
December 2019

Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy.

PLoS One 2019 20;14(11):e0224571. Epub 2019 Nov 20.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

Background: MRI-guided laser interstitial thermal therapy (MRgLITT) is a new minimally invasive treatment for temporal lobe epilepsy (TLE), with limited effectiveness data. It is unknown if the cost savings associated with shorter hospitalization could offset the high equipment cost of MRgLITT. We examined the cost-utility of MRgLITT versus surgery for TLE from healthcare payer perspective, and the value of additional research to inform policy decision on MRgLITT. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224571PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867628PMC

Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex.

Elife 2019 11 20;8. Epub 2019 Nov 20.

Institute of Neuroscience and Medicine INM-10, Research Centre Jülich GmbH, Jülich, Germany.

Synapses are fundamental building blocks controlling and modulating the 'behavior' of brain networks. How their structural composition, most notably their quantitative morphology underlie their computational properties remains rather unclear, particularly in humans. Here, excitatory synaptic boutons (SBs) in layer 4 (L4) of the temporal lobe neocortex (TLN) were quantitatively investigated. Read More

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http://dx.doi.org/10.7554/eLife.48373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919978PMC
November 2019

First add-on perampanel for focal-onset seizures: An open-label, prospective study.

Acta Neurol Scand 2020 Feb 4;141(2):132-140. Epub 2019 Dec 4.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objectives: This study aimed to determine the efficacy and safety of perampanel added to monotherapy in patients with focal-onset seizures, with or without secondarily generalized tonic-clonic seizures.

Materials & Methods: In this multicentre, open-label trial, enrolled patients were treated with perampanel monotherapy. During a 12-week titration period, perampanel was incrementally increased by 2 mg/d over ≥2-week intervals. Read More

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http://dx.doi.org/10.1111/ane.13197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973118PMC
February 2020
2.395 Impact Factor

Risk factors associated with drug resistant focal epilepsy in adults: A case control study.

Seizure 2019 Dec 5;73:46-50. Epub 2019 Nov 5.

Saskatchewan Epilepsy Program, Department of Medicine, University of Saskatchewan, Canada. Electronic address:

Purpose: Using an adult cohort of patients with focal epilepsy, we aimed to identify risk factors for development of drug-resistant epilepsy, which if identifiable would allow patients to receive appropriate counsel and earlier surgical treatment.

Methods: This is a case-control study nested within a cohort, 146 adult patients with focal epilepsy were included. Definitions were used in accordance with ILAE criteria. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.10.020DOI Listing
December 2019

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.

Lancet Neurol 2020 01 14;19(1):38-48. Epub 2019 Nov 14.

Medical Affairs, SK Life Science, Paramus, NJ, USA.

Background: More than a third of patients with epilepsy are treatment resistant, and thus new, more effective therapies to achieve seizure freedom are needed. Cenobamate (YKP3089), an investigational antiepileptic drug, has shown broad-spectrum anticonvulsant activity in preclinical studies and seizure models. We aimed to evaluate the safety, efficacy, and tolerability of adjunctive cenobamate in patients with uncontrolled focal (partial)-onset epilepsy. Read More

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http://dx.doi.org/10.1016/S1474-4422(19)30399-0DOI Listing
January 2020

Classification and management of epilepsy and epileptic syndromes in a cohort of 202 school children- a 2 year follow up study- Sudan.

BMC Neurol 2019 Nov 15;19(1):290. Epub 2019 Nov 15.

Neurology Division, Department of pediatrics and Child Health Faculty of Medicine, University of Khartoum, P. O. Box 102, Khartoum, Sudan.

Background: In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year period is presented. The applicability of the ILAE classification in resource limited countries has been revisited. Read More

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http://dx.doi.org/10.1186/s12883-019-1514-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857133PMC
November 2019

Quantitative Analysis of [18F]FFMZ and [18F]FDG PET Studies in the Localization of Seizure Onset Zone in Drug-Resistant Temporal Lobe Epilepsy.

Stereotact Funct Neurosurg 2019 13;97(4):232-240. Epub 2019 Nov 13.

Unidad Radiofarmacia-Ciclotrón, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico,

Background: Positron emission tomography (PET) imaging in epilepsy is an in vivo technique that allows the localization of a possible seizure onset zone (SOZ) during the interictal period. Stereo-electro-encephalography (SEEG) is the gold standard to define the SOZ. The objective of this research was to evaluate the accuracy of PET imaging in localizing the site of SOZ compared with SEEG. Read More

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http://dx.doi.org/10.1159/000503692DOI Listing

Mild chronic perturbation of inhibition severely alters hippocampal function.

Sci Rep 2019 11 11;9(1):16431. Epub 2019 Nov 11.

Department of Psychiatry, Washington University School of Medicine, St. Louis, USA.

Pentameric GABA receptors mediate a large share of CNS inhibition. The γ2 subunit is a typical constituent. At least 11 mutations in the γ2 subunit cause human epilepsies, making the role of γ2-containing receptors in brain function of keen basic and translational interest. Read More

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http://dx.doi.org/10.1038/s41598-019-52851-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848214PMC
November 2019
5.078 Impact Factor

Ictal kissing in a patient with right frontal lobe epilepsy.

Epileptic Disord 2019 Oct;21(5):453-457

Neurophisiology Unit, Neurology Service, Centro Hospitalar Universitário de São João, Porto.

When performing pre-surgical evaluation of patients with refractory epilepsy, the analysis of seizure semiology is one of the key elements used to generate a hypothesis about the location of the epileptogenic zone. Ictal kissing is a very rarely observed ictal automatism described in patients with temporal lobe epilepsy. We present a 62-year-old man who was referred to our epilepsy centre for comprehensive evaluation. Read More

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http://dx.doi.org/10.1684/epd.2019.1097DOI Listing
October 2019
3 Reads

Evolution of concepts in epilepsy surgery.

Authors:
Jerome Engel

Epileptic Disord 2019 Oct;21(5):391-409

Departments of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences, and the Brain Research Institute, David Geffen School of Medicine, UCLA.

At the time of the first meeting of the International League Against Epilepsy (ILAE) in 1909, surgical treatment for epilepsy had been accepted as an alternative therapy for over two decades, but was rarely practiced, considered a last resort for carefully selected patients. Localization was based on ictal semiology and identification of a structural lesion. Very few papers on epilepsy surgery were presented at ILAE meetings or published in Epilepsia during the first half of the 20 century. Read More

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http://dx.doi.org/10.1684/epd.2019.1091DOI Listing
October 2019

Lack of association of SCN2A rs17183814 polymorphism with the efficacy of lamotrigine monotherapy in patients with focal epilepsy from Herzegovina area, Bosnia and Herzegovina.

Epilepsy Res 2019 12 23;158:106221. Epub 2019 Oct 23.

Clinic of Neurology, Clinical Hospital Dubrava, 10000 Zagreb, Croatia.

Objective: We assessed the influence of the SCN2A gene polymorphism c.56 G > A rs17183814 on the response to lamotrigine monotherapy in patients with focal epilepsy in Herzegovina area, Bosnia and Herzegovina.

Material And Methods: For SCN2A polymorphism c. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.106221DOI Listing
December 2019

Learning to see the invisible: A data-driven approach to finding the underlying patterns of abnormality in visually normal brain magnetic resonance images in patients with temporal lobe epilepsy.

Epilepsia 2019 12 6;60(12):2499-2507. Epub 2019 Nov 6.

Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, University College London, London, UK.

Objective: To find the covert patterns of abnormality in patients with unilateral temporal lobe epilepsy (TLE) and visually normal brain magnetic resonance images (MRI-negative), comparing them to those with visible abnormalities (MRI-positive).

Methods: We used multimodal brain MRI from patients with unilateral TLE and employed contemporary machine learning methods to predict the known laterality of seizure onset in 104 subjects (82 MRI-positive, 22 MRI-negative). A visualization approach entitled "Importance Maps" was developed to highlight image features predictive of seizure laterality in both the MRI-positive and MRI-negative cases. Read More

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http://dx.doi.org/10.1111/epi.16380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972547PMC
December 2019

Minimally Invasive Technique (Nummular Craniotomy) for Mesial Temporal Lobe Epilepsy: A Comparison of 2 Approaches.

World Neurosurg 2020 Feb 2;134:e636-e641. Epub 2019 Nov 2.

Department of Neurosurgery, University of São Paulo, São Paulo, Brazil. Electronic address:

Objective: To describe our series of a minimally invasive technique using a small scalp incision and keyhole craniotomy for the removal of mesial temporal lobe structures through a transcortical approach in patients with medically intractable mesial temporal lobe epilepsy (MTLE). Studies that directly compare the clinical outcomes between minimally invasive and conventional techniques are scarce, and this information is lacking in the literature.

Methods: The study enrolled 73 consecutive patients with refractory MTLE and unilateral hippocampal sclerosis; 30 patients were operated on with standard frontotemporal craniotomy between 2010 and 2013 and 43 patients were operated with a minimally invasive craniotomy (nummular craniotomy) between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.160DOI Listing
February 2020

Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study.

Neuroscience 2019 12 1;423:148-161. Epub 2019 Nov 1.

Biomedical Technology Wing, Satelmond Palace Campus, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala 695012, India. Electronic address:

Several reports of augmented hyperpolarisation-activated cyclic nucleotide-gated (HCN) currents in seizures have suggested a pro-convulsive identity for HCN channels. The mutations identified in one or more of the four HCN channel subunits are found to be contributing to different epileptic phenotypes. S126L, S632W, V246M and E515K are four different mutations affecting the HCN2 subunit and have been reported in febrile seizures and partial/generalised idiopathic epilepsies. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.10.019DOI Listing
December 2019
1 Read

Subicular Pyramidal Neurons: A Key to Unlock the "Black Box" of Drug Resistance in Temporal Lobe Epilepsy.

Neurosci Bull 2019 Dec 2;35(6):1123-1125. Epub 2019 Nov 2.

Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, 310053, China.

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http://dx.doi.org/10.1007/s12264-019-00440-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863992PMC
December 2019

Effectiveness of eslicarbazepine acetate in dependency of baseline anticonvulsant therapy: Results from a German prospective multicenter clinical practice study.

Epilepsy Behav 2019 12 31;101(Pt A):106574. Epub 2019 Oct 31.

Eisai GmbH, Lyoner Str. 36, 60528 Frankfurt, Germany.

Eslicarbazepine acetate (ESL) is a third-generation antiepileptic drug (AED) approved as monotherapy for partial-onset seizures in adults and as adjunctive therapy in patients aged above 6 years in the European Union (EU). The prospective observational Zebinix Effects in DEpendency of BAseline Conditions (ZEDEBAC) study aimed at investigating the effectiveness of ESL in clinical practice, with ESL being administered as monotherapy (mono group), as only add-on to a current monotherapy (1+ group), or as add-on to ≥2 baseline AEDs (≥2+ group). In total, 237 patients were included, 35 in the mono group, 114 in the 1+, and 88 in the ≥2+ group. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106574DOI Listing
December 2019
1 Read

Pharmacokinetic interaction of brivaracetam on other antiepileptic drugs in adults with focal seizures: Pooled analysis of data from randomized clinical trials.

Epilepsy Res 2019 12 14;158:106218. Epub 2019 Oct 14.

UCB Pharma, Braine-l'Alleud, Belgium. Electronic address:

Objective: To assess the effect of brivaracetam (BRV) on steady-state plasma concentrations of commonly prescribed antiepileptic drugs (AEDs).

Methods: Data were pooled from five randomized, double-blind, placebo-controlled efficacy studies (NCT00175929, NCT00175825, NCT00490035, NCT00464269, and NCT01261325) in which adults with refractory epilepsy, and receiving stable doses of 1-2 AEDs, initiated adjunctive treatment with BRV (or placebo) for up to 12 weeks, following a 4-8 week baseline period. Concentrations of carbamazepine, carbamazepine epoxide, clobazam, clonazepam, lacosamide, lamotrigine, levetiracetam, oxcarbazepine (MHD), phenobarbital, phenytoin, pregabalin, topiramate, valproic acid and zonisamide, were measured during baseline and during BRV or placebo evaluation periods. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.106218DOI Listing
December 2019
2.015 Impact Factor