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Front Neurol 2018 30;9:995. Epub 2018 Nov 30.

American University of Beirut Medical Center, Beirut, Lebanon.

To evaluate prospectively the frequency of epileptogenic lesions in a consecutive cohort of elderly patients presenting with new onset unprovoked seizures, and who underwent a complete evaluation including dedicated epilepsy protocol MRI. We included all consecutive patients 60 years or older who participated in a prospective study on new onset epilepsy. The work-up included the acquisition of a dedicated epilepsy protocol MRI and a 3 h video/EEG recording. Read More

Epilepsia 2018 Dec 7. Epub 2018 Dec 7.

INSERM Unit U1129 Infantile Epilepsies and Brain Plasticity, University Paris Descartes, Sorbonne Paris Cité, Paris, France.

Objective: We aimed to characterize epilepsy of infancy with migrating focal seizures (EIMFS), a rare, severe early onset developmental epilepsy related to KCNT1 mutation, and to define specific electroencephalography (EEG) markers using EEG quantitative analysis. The ultimate goal would be to improve early diagnosis and to better understand seizure onset and propagation of EIMFS as compared to other early onset developmental epilepsy.

Methods: EEG of 7 EIMFS patients with KCNT1 mutations (115 seizures) and 17 patients with other early onset epilepsies (30 seizures) was included in this study. Read More

Seizure 2018 Dec 31;63:62-67. Epub 2018 Oct 31.

University of California San Diego, San Diego, CA, United States.

Purpose: Stereotactic radiosurgery (SRS) may be an alternative to anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (MTLE). Visual field defects (VFD) occur in 9-100% of patients following open surgery for MTLE. Postoperative VFD after minimally invasive versus open surgery may differ. Read More

Seizure 2018 Dec 15;63:14-16. Epub 2018 Oct 15.

National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama, Aoi-ku, Shizuoka 420-8688, Japan. Electronic address:

Seizure 2018 Dec 17;63:1-6. Epub 2018 Sep 17.

Department of Neurology, Second Faculty of Medicine, Charles University, Motol University Hospital, Czech Republic.

Purpose: Epileptic seizures are a common manifestation of autoimmune encephalitis, but the role of neural antibodies in long-term epilepsy remains unclear. The aim of this study was to assess the prevalence of neural-surface antibodies (NSAbs) and antibodies against glutamic acid decarboxylase (GAD) in patients with chronic temporal lobe epilepsy (TLE).

Method: Patients with an electro-clinical diagnosis of TLE and a disease duration longer than one year were included. Read More

Seizure 2018 Nov 29;62:116-123. Epub 2018 Sep 29.

University of Bonn, Department of Epileptology, Germany.

Purpose: Epilepsy surgery can be a successful treatment option for temporal lobe epilepsy but there are concerns about accelerated memory decline in long-term follow-up.

Method: 161 adult operated (77 right, 84 left temporal resections) versus a heterogeneous group of 208 non-operated patients with focal epilepsies were consecutively recruited and re-evaluated focusing on memory, executive functions, and vocational outcome after follow-up intervals of >5 years (5-22 years, mean 8 ± 3 years).

Results: Major losses in the operated group manifest early, at one-year follow-up. Read More

Front Pharmacol 2018 27;9:1088. Epub 2018 Sep 27.

Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. Sleep comprises two distinct stages i. Read More

Seizure 2018 Nov 14;62:84-90. Epub 2018 Sep 14.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Purpose: The aim of this trial was to compare the efficacy and safety of two formulations of levetiracetam in people with partial epilepsy over a 12-week treatment period.

Methods: We performed a randomized, paralleled, and multicenter trial that consisted of a 4-week single-blind placebo run-in, followed by a 12-week double-blind, double-dummy treatment phase to compare the efficacy and safety of levetiracetam extended-release (LEV-ER) and immediate-release (LEV-IR) tablets as an adjunctive treatment in adult patients with uncontrolled epilepsy.

Results: The median partial-onset seizure (POS) frequency per week (min-max) was 0. Read More

Seizure 2018 Nov 3;62:79-83. Epub 2018 Oct 3.

Graduate Faculty of Interdisciplinary Research, Graduate School, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.

Purpose: The main purpose of this study was to compare the efficacy of levetiracetam (LEV) with the older antiepileptic drugs (AEDs) for preventing atypical evolution in children with Rolandic epilepsy (RE). Accordingly, the present study compared the efficacy of older AEDs (carbamazepine (CBZ) and valproate sodium (VPA)) with LEV in reducing rolandic discharges (RDs) on interictal electroencephalogram (EEG) in children with RE.

Methods: Patients in this heterogenous study were subdivided into CBZ, VPA and LEV groups in accordance with the initial monotherapy. Read More

Neurodiagn J 2018 ;58(3):164-173

a Neurodiagnostic Laboratory Duke University Medical Center , Durham , North Carolina.

Subtemporal electrode chains are part of the international 10-10 system. Since 2012, they have been routinely used at our institution in adult patients with intractable epilepsy who are undergoing video EEG evaluation for epilepsy surgery. In 2016, this was extended to the pediatric population. Read More

Expert Opin Emerg Drugs 2018 09 27;23(3):243-249. Epub 2018 Sep 27.

a Institute of Medical and Biomedical Education , St George's University of London , London , UK.

Introduction: Epilepsy is one of the most serious neurological conditions, affecting almost 50 million people around the world. Despite more than 20 antiepileptic drugs (AEDs) available, seizures are still uncontrolled in one third of patients. Areas covered: The present paper reviews current compounds in preclinical and clinical development for the treatment of focal epilepsies and new potential molecular targets recently identified. Read More

Seizure 2018 Nov 17;62:3-10. Epub 2018 Sep 17.

Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Purpose: MRI-negative epilepsy patients could benefit from advanced imaging techniques such as high-resolution diffusion magnetic resonance imaging (dMRI). Our aim was to perform hippocampal subfield-specific tractography and quantify connectivity of the subfields in MRI-negative patients. Abnormal connectivity of the hippocampal subfields may help inform seizure focus hypothesis and provide information to guide surgical intervention. Read More

Epilepsy Behav 2018 Nov 18;88S:33-38. Epub 2018 Sep 18.

University of South Florida, Tampa, FL, United States.

For drug-resistant epilepsy, nonpharmacologic treatments should be considered early rather than late. Of the nondrug treatments, only resective surgery can be curative. Neurostimulation is palliative, i. Read More

Neurophysiol Clin 2018 Oct 15;48(5):277-286. Epub 2018 Sep 15.

NeuroPain Team, Inserm U 1028/CNRS, UMR 5292, University of Lyon, Lyon Neuroscience Research Centre (CRNL), 69677 Bron, France.

Objective: Differential diagnosis between sleep-related epileptic seizures and NREM parasomnia remains challenging. Pathophysiological markers to differentiate both conditions are needed. Activation of autonomic system is present in arousal reactions and epileptic seizures. Read More

World Neurosurg 2018 Dec 14;120:337-342. Epub 2018 Sep 14.

Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

Background: Ictal asystole (IA) and ictal bradycardia (IB) are mainly seen with temporal or frontal lobe epilepsy. Many patients with these conditions undergo cardiac pacemaker therapy but not epilepsy surgery.

Case Description: We report the case of a 15-year-old boy with IA and IB secondary to right posterior quadrant epilepsy (PoQE) who underwent right posterior quadrant disconnection, but not cardiac pacemaker implantation. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):676-681

Department of Pathology, Beijing Haidian Hospital/Haidian Section of Peking University Third Hospital, Beijing 100080, China.

To investigate the clinicopathologic features of Rasmussen syndrome (RS) and to raise awareness of this rare disease. Clinicopathologic data of 4 cases of RS were retrospectively analyzed at Beijing Haidian Hospital from 2008 to 2016. The clinical manifestations included epilepsia partialis continua and progressive neurologic deficits in all patients. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):671-675

Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

To investigate the clinicpathologic features and probable mechanisms of massive subcortical heterotopia. Clinical data, histologic features and neuropathologic data were analyzed in five cases of massive subcortical heterotopia collected from Xuanwu Hospital, Capital Medical University from January 2014 to October 2017. All five patients (three males and two females) had a history of refractory epilepsy with a mean period of 15. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):664-670

Department of Pathology, Capital Medical University, Beijing 100010, China.

To investigate the clinicopathologic characteristics and BRAF V600E mutation of brain tumors associated with epilepsy. Totally 250 patients with brain tumors associated with epilepsy were included from March 2008 to August 2017 retrospectively at Sanbo Brain Hospital, Capital Medical University.The clinical manifestations, histological features and BRAF V600E mutation results were collected and analyzed. Read More

Exp Neurol 2018 Dec 8;310:70-83. Epub 2018 Sep 8.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

Cell transplantation based therapy is a promising strategy for treating intractable epilepsies. Inhibition of the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNr) is a powerful experimental approach for remote control of different partial seizure types, when targeting the seizure focus is not amenable. Here, we tested the hypothesis that grafting of embryonic/fetal neural precursor cells (NPCs) from various species (rat, human, pig) into STN or SNr of adult rats induces anticonvulsant effects. Read More

J Neurol 2018 Nov 1;265(11):2594-2601. Epub 2018 Sep 1.

Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.

Purpose: S100B, a cytokine produced by astrocytes, has been studied as a biomarker of glial and neuronal damage in epilepsy. The present study investigated the reliability of serum S100B as a biomarker and the effect of carbamazepine and oxcarbazepine on serum S100B in patients with focal seizure.

Methods: The present randomized, open-label, active-controlled, parallel design clinical trial (NCT02705768) conducted on 60 patients with focal seizure. Read More

Life Sci 2018 Sep 13;209:403-408. Epub 2018 Aug 13.

Department of Neurology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

Aims: Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period.

Main Methods: A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into this study. These patients were divided into three pairs of groups: less frequent seizure group and more frequent seizure group; medication group and non-medication group; <10 years disease group and ≥10 years disease group. Read More

Medicine (Baltimore) 2018 Aug;97(33):e11803

Department of Medical Imaging, Fuzhou General Hospital, Xi'erhuan Beilu, Fuzhou, Fujian, PR China.

Noninvasive imaging plays a pivotal role in assessing the brain structural and functional changes in presurgical mesial temporal lobe epilepsy (MTLE) patients. Our goal was to study the relationship between the changes of cerebral white matter (WM) and cognitive functions in MTLE patients.Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) MRI were performed on 24 right-handed MTLE patients (12 with left MTLE and 12 with right MTLE) and 12 matching healthy controls. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jun;43(6):638-645

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To compare the anterior temporal lobectomy (ATL) with transsylvian selective amygdalohippocampectomy (SeAH) in 72 patients with medial temporal lobe epilepsy (MTLE) regarding the seizure control and neuropsychological outcomes.
 Methods: Clinical data and follow-up data were collected and retrospectively analyzed. SeAH and ATL were used in 39 and 33 patients, respectively. Read More

Seizure 2018 Oct 17;61:63-70. Epub 2018 Jul 17.

Department of Neurology, Division of Clinical Neuroscience, Rikshospitalet, Oslo University Hospital, Oslo, Norway. Electronic address:

Purpose: To evaluate risk factors for drug resistance and polypharmacy in patients with temporal lobe epilepsy.

Methods: Patients with temporal lobe epilepsy, treated for more than 5 years, completed questionnaires on antiepileptic drug use and effect. Logistic regression models were used for analysis of risk factors. Read More

Rinsho Shinkeigaku 2018 Aug 31;58(8):492-498. Epub 2018 Jul 31.

Department of Neurology, Tenri Hospital.

A 69-year-old female with an old infarct of the left parietotemporal lobe was admitted for the evaluation of suspected painful seizures accompanying ictal paresis. The painful seizure and ictal paresis involved her right extremities without convulsions, although intermittent tremulous movements were noted on the right upper extremity. She also showed right hemianopia during the seizure. Read More

Rinsho Shinkeigaku 2018 Aug 31;58(8):513-516. Epub 2018 Jul 31.

Department of Neurology, Kyoto University Graduate School of Medicine.

Promnesia is a feeling of familiarity and foreknowledge and is a manifestation of simple partial seizures (focal aware seizures). It is similar to déjà vu and has been reported to be a rare symptom in patients with temporal lobe epilepsy. Here, we investigated the clinical characteristics in 4 patients with partial epilepsy presenting promnesia. Read More

Arq Neuropsiquiatr 2018 Jul;76(7):495-496

University of Kentucky Department of Neurology, Lexington, KY, USA.

World Neurosurg 2018 Nov 29;119:e209-e215. Epub 2018 Jul 29.

Department of Neurosurgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Objective: The optimal surgical treatment for cavernous malformation-related temporal lobe epilepsy (CRTLE) is still controversial because it frequently involves the hippocampus as an epileptogenic zone. Here we describe our unique surgical strategy of performing hippocampal transection (HT) plus tumor resection for CRTLE to solve the question of how to balance postoperative seizure outcomes and neuropsychologic outcomes.

Methods: From 2005 to 2016, 7 cases of HT (3 on dominant side) plus tumor resection were performed for patients with CRTLE. Read More

Epileptic Disord 2018 Aug;20(4):295-300

Pediatric Neurology Unit, University Hospitals Geneva, Switzerland.

Epileptic spasms represent a subcategory of motor seizures that have been extensively documented and recently re-classified by the International League Against Epilepsy as either generalized, focal or of unknown onset. Atypical characteristics continue to be reported in case studies, emphasizing the divergent morphological traits and putting into question the underlying aetiopathophysiology. Here, we report the findings of an infant with a triad of clinical manifestations during a single ictal event, comprising a cluster of epileptic spasms, vertical binocular nystagmus, and a focal tonic seizure. Read More

Seizure 2018 Oct 10;61:8-13. Epub 2018 Jul 10.

Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka 560029, India; Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka 560029, India. Electronic address:

Purpose: Quasi-stable electrical distribution in EEG called microstates could carry useful information on the dynamics of large scale brain networks. Using machine learning techniques we explored if abnormalities in microstates can identify patients with Temporal Lobe Epilepsy (TLE) in the absence of an interictal discharge (IED).

Method: 4 Classes of microstates were computed from 2 min artefact free EEG epochs in 42 subjects (21 TLE and 21 controls). Read More

Proc Natl Acad Sci U S A 2018 08 23;115(32):E7595-E7604. Epub 2018 Jul 23.

Psychological Sciences Research Institute, UCLouvain, B-1348 Louvain-La-Neuve, Belgium.

We report a comprehensive cartography of selective responses to visual letters and words in the human ventral occipito-temporal cortex (VOTC) with direct neural recordings, clarifying key aspects of the neural basis of reading. Intracerebral recordings were performed in a large group of patients ( = 37) presented with visual words inserted periodically in rapid sequences of pseudofonts, nonwords, or pseudowords, enabling classification of responses at three levels of word processing: letter, prelexical, and lexical. While letter-selective responses are found in much of the VOTC, with a higher proportion in left posterior regions, prelexical/lexical responses are confined to the middle and anterior sections of the left fusiform gyrus. Read More

Seizure 2018 Aug 11;60:178-183. Epub 2018 Jul 11.

Epilepsy Center, Department of Neurology, University Hospital, LMU Munich, Munich, Germany.

Purpose: To investigate the frequency, localizing significance, and intensity characteristics of ictal vocalization in different focal epilepsy syndromes.

Methods: Up to four consecutive focal seizures were evaluated in 277 patients with lesional focal epilepsy, excluding isolated auras and subclinical EEG seizure patterns. Vocalization was considered to be present if observed in at least one of the analyzed seizures and not being of speech quality. Read More

Seizure 2018 Aug 7;60:159-162. Epub 2018 Jul 7.

Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Brazil; Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil. Electronic address:

Purpose: Some variants of the brain derived neurotrophic factors (BDNF) gene, namely the Val66Met (rs6265), may contribute the risk for epilepsy development. We aimed to investigate if this polymorphism was associated with the risk for epilepsy development in TLE-HS and its correlation with epilepsy-related factors and the presence of psychiatric disorders.

Methods: We assessed 119 patients with unequivocal TLE-HS and 112 healthy controls. Read More

Hell J Nucl Med 2018 May-Aug;21(2):95-101. Epub 2018 Jul 12.

Department of Radiology, Division of Nuclear Medicine, Hospital of the University of Pennsylvania, USA.

Objective: The purpose of this study was to evaluate the utility of global semi-quantitative analysis via fluorine-18-flurodeoxyglucose positron emission tomography (F-FDG PET) at lateralizing seizure foci and diagnosing patients with unilateral temporal lobe epilepsy (TLE).

Methods: Seventeen patients with unilateral TLE (11 right TLE and 6 left TLE) were retrospectively selected for semi-quantitative F-FDG PET analysis. Twenty-three control subjects with a Mini Mental State Examination (MMSE) score of 29 or greater were selected for comparison. Read More

Seizure 2018 Aug 7;60:157-158. Epub 2018 Jul 7.

Clinical Neurosciences, Royal Free London NHS Foundation Trust, United Kingdom; Institute of Neurology, University College London, United Kingdom; Centre for Research in Public Health and Community Care, University of Hertfordshire, United Kingdom.

Clin Neuropharmacol 2018 Jul/Aug;41(4):116-122

Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt.

Objectives: Pregabalin (PGB) is a gabapentinoid (ie, GABA analog), which has been Food and Drug Administration-approved for treatment of partial epilepsy in adults and neuropathic pain. It also has off-label uses for the treatment of generalized anxiety disorders, fibromyalgia, and tension headache and prevention of migraine. Few cases were reported with sexual dysfunctions (SDs) as adverse effects of PGB and gabapentin, and the majority were dose related (≥900 mg/d for gabapentin). Read More

Cochrane Database Syst Rev 2018 07 11;7:CD009258. Epub 2018 Jul 11.

Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, E4-145, MLC 2015, 3333 Burnet Avenue, Cincinnati, Ohio, USA, 45229.

Background: This is an updated version of the original Cochrane Review published in Issue 10, 2014. There is a need to expand monotherapy options available to a clinician for the treatment of new focal or generalized seizures. A Cochrane systematic review for clobazam monotherapy is expected to define its place in the treatment of new-onset or untreated seizures and highlight gaps in evidence. Read More

Acta Neurol Scand 2018 Nov 10;138(5):432-440. Epub 2018 Jul 10.

Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objectives: The aim of this study was to understand the relationship between cortical morphology, centrotemporal spike (CTS), and neuropsychological functioning in children with BECTS compared to their typically developing peers.

Materials And Methods: To examine whole-brain differences in cortical thickness between groups, a general linear model approach was applied to T1-weighted structural magnetic resonance imaging (MRI) in children with BECTS and typically developing children. Further region-of-interest (ROI) analyses were performed to examine the effects of frequency and lateralization of CTS. Read More

Psychopharmacology (Berl) 2018 Sep 8;235(9):2665-2673. Epub 2018 Jul 8.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.

Rationale: Valproate (VPA) is a choice for the treatment of primary generalized epilepsies and partial epilepsies. Unfortunately, weight gain or obesity is one of the most frequent adverse effects of VPA treatment. Genetic factors were shown to be involved in the effect. Read More

Semin Pediatr Neurol 2018 07 23;26:95-100. Epub 2017 May 23.

From the Pediatric Neurology Division, Nationwide Children's Hospital, The Ohio State University, Columbus, OH.

We discuss an unusual case of a teenage boy who presented with waxing and waning cognitive decline and gelastic-dacrystic seizures, evolving later into a rapidly progressive encephalopathy with status epilepticus. Extensive genetic and metabolic testing did not lead to a specific diagnosis. Cerebrospinal fluid studies performed during admission to the intensive care unit provided the information needed to establish a diagnosis. Read More

Semin Pediatr Neurol 2018 07 2;26:68-73. Epub 2017 Apr 2.

Department of Child and Adolescent Neurology, Mayo Clinic, Rochester, MN. Electronic address:

There is increasing evidence to demonstrate that Parry-Romberg syndrome and linear scleroderma en coup de sabre are both forms of linear scleroderma, representing localized autoimmune conditions affecting the skin, eyes, brain, and surrounding tissues. We present a case highlighting the clinical presentation of a 12-year-old boy with focal seizures and physical examination findings of facial atrophy and hair loss. This article reviews the literature related to the presentation, epidemiology, diagnosis, and treatment of Parry-Romberg syndrome and linear scleroderma en coupe de sabre with focus on the significant correlation with neurologic disease, particularly seizures. Read More

J Clin Neurosci 2018 Sep 27;55:76-81. Epub 2018 Jun 27.

Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea. Electronic address:

The thalamus plays an important role in the modulation of both focal and generalized seizures, but the mechanisms related to seizures may be different among epilepsy syndromes. The aim of this study is to investigate the thalamic atrophy in different epilepsy syndromes. We enrolled a total of 72 patients with epilepsy (22 patients with temporal lobe epilepsy with hippocampal sclerosis, 21 patients with extra-temporal lobe epilepsy, and 29 patients with juvenile myoclonic epilepsy). Read More

Seizure 2018 Aug 15;60:123-126. Epub 2018 Jun 15.

Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan 612-896, Republic of Korea. Electronic address:

Purpose: Oxcarbazepine is known as an effective first-line monotherapy for pediatric focal epilepsy. Lamotrigine has also been reported to have similar efficacy to and better tolerability than carbamazepine. Therefore, the effectiveness of oxcarbazepine and lamotrigine monotherapies was compared in patients with pediatric focal epilepsy. Read More

Epilepsia 2018 Aug 28;59(8):1583-1594. Epub 2018 Jun 28.

Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA.

Objective: Detection of focal cortical dysplasia (FCD) is of paramount importance in epilepsy presurgical evaluation. Our study aims at utilizing quantitative positron emission tomography (QPET) analysis to complement magnetic resonance imaging (MRI) postprocessing by a morphometric analysis program (MAP) to facilitate automated identification of subtle FCD.

Methods: We retrospectively included a consecutive cohort of surgical patients who had a negative preoperative MRI by radiology report. Read More

Epilepsia 2018 Jun 28. Epub 2018 Jun 28.

Department of Neurology, Christian Doppler Klinik, University Hospital Paracelsus Medical University, Salzburg, Austria.

This article reviews the profile of perampanel, a novel noncompetitive α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor antagonist, and its role as a potential broad-spectrum antiepileptic drug in the treatment of epilepsy. For this narrative review, data were collected using specified search criteria. Articles reporting the evidence for perampanel's efficacy from preclinical models, phase 3 clinical studies, observational studies, and descriptive evidence were included. Read More

Medicine (Baltimore) 2018 Jun;97(26):e11239

Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Default-mode network (DMN) plays a key role in a broad-scale cognitive problem, which occurs in temporal lobe epilepsy (TLE). However, little is known about the alterations of the network homogeneity (NH) of DMN in TLE. In the present study, we employed NH method to investigate the NH of DMN in TLE at rest. Read More

Cochrane Database Syst Rev 2018 06 28;6:CD001031. Epub 2018 Jun 28.

Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Hill, Liverpool, UK, L69 3GL.

Background: This is an updated version of the original Cochrane Review published in Issue 11, 2006 of the Cochrane Database of Systematic Reviews.Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment up to 70% of individuals with active epilepsy have the potential to become seizure-free, and to go into long-term remission shortly after starting drug therapy with a single antiepileptic drug (AED) in monotherapy. Read More

J Neurol 2018 Sep 26;265(9):1998-2004. Epub 2018 Jun 26.

Department of Neurosurgery, Hospices Civils de Lyon, Neurology and Neurosurgery Hospital Pierre Wertheimer, 59, Bd Pinel, 69677, Bron, France.

Background: Stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) is a super-selective procedure. Hippocampus has a limited volume and is widely accessible to SEEG so that SEEG-guided RF-TC could be an alternative to the anterior temporal lobectomy (ATL) in case of temporal lobe epilepsy (TLE) syndrome.

Objective: To compare seizure-free rate at 1-year follow-up between patients undergoing SEEG-guided RF-TC and patients undergoing ATL in TLE over a 15-year period. Read More

J Clin Neurosci 2018 Sep 20;55:38-44. Epub 2018 Jun 20.

Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada; Department of Medical Imaging, Western University, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; Department of Psychology, Western University, London, Ontario, Canada. Electronic address:

This study was aimed to longitudinally assess memory function and whole-brain memory circuit reorganization in patients with temporal lobe epilepsy (TLE) by comparing activation potentials before versus after anterior temporal lobe (ATL) resection. Nineteen patients with medically-intractable TLE (10 left TLE, 9 right TLE) and 15 healthy controls were enrolled. Group analyses were conducted pre- and post-ATL of a novelty complex scene-encoding paradigm comparing areas of blood oxygen-level-dependent (BOLD) signal activations on functional magnetic resonance imaging (fMRI). Read More