28,632 results match your criteria Paroxysmal Nocturnal Hemoglobinuria


[Analysis of nystagmus and medical history of 121 patients positive with positional test].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1491-1494

Department of Otolaryngology, Kuang Tien General Hospital, Taichung, Taiwan.

To observe the characteristics of positional nystagmus and clinical profile of patients with positive positional test, and to explore its possible pathogenesis. One hundred and twenty-one patients with positive positional test in the vestibular function examination were enrolled in the Peking University International Hospital from January to June in 2017. According to the 2017 BPPV guidelines, patients with test positive positional nystagmus were divided into two groups: definite BPPV and the controversial syndrome. Read More

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October 2018

[The clinical characteristics of the evoked nystagmus in the non-affected side during Dix-Hallpike test in the unilateral posterior semicircular canal benign paroxysmal positional vertigo].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1451-1454

Department of Otolaryngology Head and Neck Surgery, the First Hospital, Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province.

To investigate the clinical characteristics of the evoked nystagmus in the non-affected side during Dix-Hallpike test(D-H test)in unilateral posterior semicircular canal benign paroxysmal positional vertigo(PC-BPPV). Two hundred and thirty-six patients were diagnosed with unilateral PC-BPPV in the Tinnitus and Dizziness clinic.Among them,14 patients exhibited positive nystagmus when the non-affected side was stimulated by D-H test. Read More

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October 2018

[Characteristics analysis of patients with benign paroxysmal positional vertigo-spontaneously cured].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1426-1428

Department of Otolaryngology Head and Neck Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University.

To analyze the characteristics of patients with benign paroxysmal positional vertigo which were spontaneously cured. A total of 1 257 patients with chief complaint of positional vertigo were included and analyzed retrospectively, in which 921 cases were diagnosed as BPPV with the diagnosis standard of Guiyang meeting, and the other 336 cases were negative in the positional test diagnosed as BPPV-spontaneously cured. The age,gender and history course of the two groups were analyzed respectively. Read More

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September 2018

[Interpretation of updated version of BPPV clinical practice guideline: treatment and patient education].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1367-1371

In 2008, American Academy of Otorhinolaryngology Head and Neck Surgery(AAOHNSF) published the first clinical practice guideline for benign paroxysmal positional vertigo (BPPV), in which 13 key action statements for BPPV diagnosis, treatment, and patient education were proposed. The updated version of guideline was published in 2017. This article aimed at interpreting the updated guideline with particular focus on BPPV treatment and patient education. Read More

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September 2018

[Clincal analysis of missed diagnosis and misdiagnosis of benign paroxysmal positional vertigo].

Authors:
X Wang Y S Xu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1904-1905

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December 2018

Gender differences in symptoms and functional status in patients with atrial fibrillation undergoing catheter ablation.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Chapel Hill: Department of Medicine, Division of Cardiology, University of North Carolina, 160 Dental Circle CB#7075, Chapel Hill, NC 27599, USA.

Background: Catheter ablation improves symptoms and quality of life in patients with atrial fibrillation (AF); however, despite its benefit, women are less likely than men to undergo catheter ablation. Women with AF have been described to have more frequent and severe symptoms with a lower quality of life than men, and it is therefore unclear why women are less likely to undergo catheter ablation. We prospectively characterized gender differences in AF symptoms among men and women undergoing ablation at UNC using questionnaire data. Read More

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December 2018

Alternating hemiplegia of childhood: the gap between paroxysmal manifestations and non-paroxysmal characteristics.

Dev Med Child Neurol 2018 Dec 13. Epub 2018 Dec 13.

Hôpital Femme Mère Enfant - Epilepsy, Sleep and Pediatric Neurophysiology Unit, Bron, France.

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December 2018

Surgical repair of severe mitral valve regurgitation complicated by incomplete cor triatriatum.

J Cardiol Cases 2014 Jan 13;9(1):29-31. Epub 2013 Dec 13.

Department of Cardiology, KKR Sapporo Medical Center, Hiragishi 1-6, Toyohira-ku, Sapporo, Hokkaido 062-0931, Japan.

A 69-year-old woman with exertional dyspnea was referred emergently to our hospital for further evaluation. Transthoracic echocardiography showed severe mitral valve regurgitation and moderate tricuspid regurgitation, which were thought to be the main cause of her heart failure. An electrocardiogram showed paroxysmal atrial fibrillation. Read More

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January 2014

A case of paroxysmal pheochromocytoma concurrent with coronary artery aneurysm presenting as acute coronary syndrome.

J Cardiol Cases 2013 Aug 25;8(2):e72-e76. Epub 2013 Jun 25.

Department of Cardiology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, 1-9-6 Senda-machi, Naka-ku, Hiroshima 730-8619 Japan.

A 51-year-old man recently diagnosed with preclinical Cushing's syndrome complained of chest oppression concomitant with back pain. Following contrast-enhanced computed tomography (CT) to rule out acute aortic dissection, he developed chest symptoms accompanied by elevation of blood pressure to 240/120 mmHg and ischemic electrocardiographic change. Urgent coronary angiography revealed a coronary artery aneurysm (15 mm × 6 mm) in the distal portion of the left anterior descending artery concomitant with coronary flow delay. Read More

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Recurrent paroxysmal atrial fibrillation induced by marked hypoxia during sleep-disordered breathing.

J Cardiol Cases 2016 Sep 3;14(3):87-89. Epub 2016 Jun 3.

Department of Cardiovascular Medicine, Saiseikai Futsukaichi Hospital, Fukuoka, Japan.

Sleep-disordered breathing (SDB) has a big impact on autonomic nervous activity and thus induces or deteriorates various cardiovascular diseases. We here describe a typical but rarely documented case which clearly indicates a strong link between SDB and cardiovascular disease. A 68-year-old woman complaining of frequent palpitations was referred to our institute. Read More

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September 2016

Rapid and dynamic changes of N-terminal proB-type natriuretic peptide (NT-proBNP) in a patient during paroxysmal atrial fibrillation (PAF).

J Cardiol Cases 2016 Jan 20;13(1):14-16. Epub 2015 Oct 20.

Division of Health Science, Osaka University Graduate School of Medicine, Osaka, Japan.

N-terminal proB-type natriuretic peptide (NT-proBNP) is known as a marker of heart failure (HF). NT-proBNP is also elevated in a patient with atrial fibrillation (AF). In this case report, serial assays of NT-proBNP were performed in AF attack without HF. Read More

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January 2016

Left ventricular apical aneurysm in chronic Chagas cardiomyopathy-A case report.

J Cardiol Cases 2014 Sep 14;10(3):88-90. Epub 2014 Jul 14.

Department of Cardiology, Jackson Memorial Hospital, Miami, FL, USA.

A 56-year-old female, who immigrated to the USA from Honduras, presented with worsening shortness of breath, orthopnea, paroxysmal nocturnal dyspnea, and decreased exercise tolerance over the previous 2 months. She was diagnosed 1 year previously with non-ischemic dilated cardiomyopathy and non-sustained monomorphic ventricular tachycardia. An implantable cardioverter defibrillator was placed. Read More

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September 2014

A case report: 201Tl/99mTc-Pyrophosphate dual-isotope myocardial SPECT for detecting annular subendocardial infarction induced by a transient shock.

J Cardiol Cases 2010 Oct 7;2(2):e63-e66. Epub 2016 Jun 7.

Division of Cardiology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan.

The patient was a 74-year-old woman with angina pectoris, who had undergone percutaneous coronary intervention with stent placement in the right coronary artery on October 2, 2007. On November 12 of the same year, she suffered from paroxysmal atrial fibrillation. She was treated with pilsicainide hydrochloride administered by intravenous injection, which was followed by a sudden sinus standstill, with marked bradycardia and a shock state. Read More

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October 2010

Left atrial thrombus in a patient without mitral valve disease or atrial fibrillation.

J Cardiol Cases 2016 Oct 2;14(4):115-118. Epub 2016 Jul 2.

Department of Cardiovascular Surgery, Showa University, Tokyo, Japan.

A 54-year-old man presented with back pain. His medical history included hypertension and gout. There was no history of heart disease or arrhythmia. Read More

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October 2016

A rare appearance of a large mural thrombus in left atrium detected two years after the Maze procedure.

J Cardiol Cases 2016 Feb 3;13(2):52-55. Epub 2015 Dec 3.

Department of Cardiovascular Medicine, Nantan General Hospital, Kyoto, Japan.

A 77-year-old Japanese woman underwent bioprosthetic aortic valve replacement (AVR) and the Maze procedure for severe aortic valve disease and paroxysmal atrial fibrillation (AF), and one year after the AVR, she also underwent a permanent pacemaker implantation for sick sinus syndrome. At two postoperative years, a large mural mass happened to be detected in her left atrium on routine trans-thoracic echocardiography. The cardiac rhythm records produced by the implanted pacemaker demonstrated the recurrence of AF. Read More

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February 2016

Catheter ablation of persistent atrial fibrillation solely guided by complex fractionated atrial electrograms in a patient with persistent left superior vena cava.

J Cardiol Cases 2010 Jun 24;1(3):e154-e157. Epub 2010 Feb 24.

Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.

Catheter ablation in patients with persistent atrial fibrillation (AF) is challenging. There are few reports of catheter ablation for persistent AF with persistent left superior vena cava (PLSVC). We report an ablation case of persistent AF with PLSVC solely guided by complex fractionated atrial electrogram (CFAE). Read More

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Lambda-like ST-segment elevation in acute myocardial infarction triggered by coronary spasm may be a new risk predictor for lethal ventricular arrhythmia: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13561

Department of Cardiology.

Rationale: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon.

Patient Concerns: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms. Read More

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December 2018

Complete remission after hypofractionated radiotherapy for a patient with inoperable adenoid cystic carcinoma of bronchus: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13463

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Tracheobronchial adenoid cystic carcinoma (TACC) is a rare malignancy. Surgical resection remains the standard treatment of choice. But it is frequently unresectable due to its local extension. Read More

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December 2018
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Risk factor of benign paroxysmal positional vertigo in trauma patients: A retrospective analysis using Korean trauma database.

Medicine (Baltimore) 2018 Dec;97(49):e13150

Department of Trauma Surgery, Ujeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Benign paroxysmal positional vertigo (BPPV) is a comorbid condition prevalent in patients recovering from trauma. Due to the paucity of studies investigating the etiology of this condition, the present study sought to analyze the high-risk group of BPPV patients following trauma.Trauma patients visiting the emergency department from January to December 2016 were enrolled. Read More

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December 2018

Identifying clinical complexity in patients affected by severe acquired brain injury in neurorehabilitation: a cross sectional survey.

Eur J Phys Rehabil Med 2018 Dec 13. Epub 2018 Dec 13.

Neurorehabilitation Unit, Department of Rehabilitation, HABILITA, Zingonia di Ciserano, Bergamo, Italy.

Background: Literature shows that occurrence of comorbidities in people with severe acquired brain injury (sABI) is a common problem in rehabilitation stay. Consequently, patients could require an increase of interventions for diagnosis and treatment of clinical conditions, with a reduction of the rehabilitative take in charge for both clinical and organizational aspects.

Aim: The first aim was to evaluate the rate of clinical conditions of sABI patients at admission in rehabilitation and the types of rehabilitative interventions performed in the first week; second objective was to explore the impact of clinical conditions on real rehabilitative take in charge. Read More

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December 2018

[Significance of the items for Dizziness Handicap Inventory in differential diagnosis of benign paroxysmal positional vertigo].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1145-1150

Department of Otorhinolaryngology Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To explore the value of items for the Chinese version of Dizziness Handicap Inventory (DHI) in differential diagnosis of benign paroxysmal positional vertigo (BPPV) in patients with vertigo or dizziness first coming to the outpatient clinic.
 Methods: A total of 322 patients with vertigo or dizziness, who came from Nanfang Hospital, Southern Medical University, were enrolled from April 2016 to February 2017. The Chinese version of DHI and Visual Analogue Scale (VAS) were completed by themselves. Read More

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October 2018

Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

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December 2018

Cryoballoon Ablation for the Treatment of Atrial Fibrillation: A Meta-Analysis.

Curr Cardiol Rev 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Nassau University Medical Center, East Meadow, NY. United States.

Background: Ablation therapy is the treatment of choice in antiarrhythmic drug refractory atrial fibrillation (AF). It is performed by either cryoballoon ablation (CBA) or radiofrequency ablation. CBA is gaining popularity due to simplicity with similar efficacy and complication rate compared with RFA. Read More

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December 2018

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus.

Case Rep Hematol 2018 13;2018:7586719. Epub 2018 Nov 13.

Division of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USA.

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. Read More

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November 2018

Clinical Study Regarding Arrhythmogenic Risk Factors and Oxidative Stress Inductibility in Young People.

Curr Health Sci J 2015 Jul-Sep;41(3):251-258. Epub 2015 Mar 15.

Department of Rheumatology, University of Medicine and Pharmacy of Craiova.

Rhythm disorders in young people are often reported and when they are persistent, repetitive or with a severity degree, an ethiopathgenical assessment of arrhythmogenic risk factors and their implications is required.

Purpose: Arrhythmogenic risk factors evaluation and the possibility of determining oxidative stress in the arrhythmic pathology in young people.

Material And Methods: The study was conducted on 184 young subjects, aged 16-26 years old; the points of interest were: the presence or absence of cardiac dysrhythmias, the existence of proarrhythmogenic risk factors and determination of oxidative stress status modifications. Read More

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A case of idiopathic ventricular fibrillation in which implanted loop recorder was useful in application decision for implantation of implantable cardioverter-defibrillator.

J Cardiol Cases 2012 Aug 20;6(2):e59-e63. Epub 2012 Jun 20.

Division of Cardiology, Department of Internal Medicine, Uwajima City Hospital, Goten-machi 1-1, Uwajima, Ehime 798-8510, Japan.

Establishing a symptom-rhythm correlation in patients with unexplained syncope is complicated because of its sporadic, infrequent, and unpredictable nature. Recently, an implantable loop recorder (ILR) has become available to evaluate undiagnosed recurrent arrhythmic episodes particularly in unexplained syncopes, and its usefulness has been reported in patients with recurrent syncopes that remain unexplained after conventional work-up. A 65-year-old man was referred to our hospital for loss of consciousness with nocturnal paroxysmal seizures. Read More

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Fluorodeoxyglucose accumulation in the left atrial appendage of a patient with paroxysmal atrial fibrillation.

J Cardiol Cases 2012 Feb 4;5(1):e32-e35. Epub 2011 Oct 4.

Department of Radiology, University of Fukui, Fukui, Japan.

A 69-year-old man with a history of paroxysmal atrial fibrillation (PAF) and subsequent cerebral infarction was referred to our hospital because of an abnormal accumulation of F-fluorodeoxyglucose (FDG) in the left atrial appendage (LAA) that was detected on positron emission tomography-computed tomography (PET-CT) imaging during a health screening. Transesophageal echocardiography (TEE) demonstrated thrombus formation in the LAA. Even after the thrombus disappeared by strictly guided oral anticoagulant therapy, intense abnormal FDG uptake in the LAA on PET-CT imaging persisted. Read More

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February 2012

The case of successful catheter ablation using only the approach from the upper part of the subject's body, with meandering aorta and implanted IVC filter.

J Cardiol Cases 2011 Oct 19;4(2):e115-e120. Epub 2011 Aug 19.

Second Department of Internal Medicine, Kansai Medical University, Moriguchi City, Japan.

A 79-year-old female had paroxysmal supraventricular tachycardia. However, she was implanted with an inferior vena cava filter and her descending aorta had significant meandering. It was thought that the insertion of the catheters would be difficult from the femoral vessels. Read More

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October 2011

A case of ventricular asystole without escape rhythm 4 days after percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy with drug-resistant paroxysmal atrial fibrillation.

J Cardiol Cases 2011 Oct 11;4(2):e110-e114. Epub 2011 Aug 11.

Division of Cardiology, Hokkaido Chuo Rosai Hospital, Iwamizawa, Hokkaido, Japan.

A 42-year-old man with a more than 10-year history of hypertrophic obstructive cardiomyopathy, but no history of heart failure or syncope, had left ventricular outflow tract pressure gradient (LVOT-PG) of 50-80 mmHg on Doppler echocardiography. In June 2010, he experienced general malaise on effort, and LVOT-PG increased to 124 mmHg. Two months later, he suffered a transient ischemic attack, complicated with atrial fibrillation (AF). Read More

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October 2011

Comparison of phase-mapping and electrogram-based driver mapping for catheter ablation in atrial fibrillation.

Pacing Clin Electrophysiol 2018 Dec 10. Epub 2018 Dec 10.

Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang-Ming University.

Introduction: Adjunctive driver-guided ablation in addition to pulmonary vein isolation has been proposed as a strategy to improve procedural success and outcomes for various populations with atrial fibrillation (AF). This study firstly aimed to evaluate the different mapping techniques for driver/rotor identification and secondly to evaluate the benefit of driver/rotor guided ablation in patients with paroxysmal and persistent AF.

Methods: We searched the electronic database in PubMed using the keywords "atrial fibrillation", "rotor", "rotational driver", "atrial fibrillation source", and "drivers" for both randomized controlled trials and observational controlled trials. Read More

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December 2018
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Adenosine plasma level in patients with paroxysmal or persistent atrial fibrillation and normal heart during ablation procedure and/or cardioversion.

Purinergic Signal 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiology, Timone University Hospital, 13005, Marseille, France.

The mechanism of atrial fibrillation (AF) in patients with normal heart remains unclear. While exogenous adenosine can trigger AF, nothing is known about the behavior of endogenous adenosine plasma level (APL) at the onset of AF and during ablation procedure. Ninety-one patients (68 with paroxysmal AF: 40 males, 66 ± 16 years; 23 with persistent AF: 14 males, 69 ± 11 years) and 18 controls were included. Read More

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December 2018

Is there a difference in rhythm outcome between patients undergoing first line versus second line paroxysmal atrial fibrillation ablation?

PLoS One 2018 7;13(12):e0208994. Epub 2018 Dec 7.

Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Background: Catheter ablation of atrial fibrillation (AF) is an established second line therapy for patients with symptomatic paroxysmal AF (PAF) and may be considered as a first line therapy in selected patients who are highly symptomatic, considering patient choice, benefit, and risk, according to recent guidelines. Our study investigated whether a first line vs. second line ablation approach may result in improved sinus rhythm maintenance after ablation. Read More

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December 2018

Cortical stimulation for treatment of neurological disorders of hyperexcitability: a role of homeostatic plasticity.

Neural Regen Res 2019 Jan;14(1):34-38

Department of Anatomy and Cell Biology, Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management of them is to suppress this hyperexcitability, such as having been exemplified by the use of certain antiepileptic drugs, their frequent refractoriness to drug treatment suggests likely different pathophysiological mechanism. Because the pathogenesis in these disorders exhibits a transition from an initial activity loss after injury or sensory deprivation to subsequent hyperexcitability and paroxysmal discharges, this process can be regarded as a process of functional compensation similar to homeostatic plasticity regulation, in which a set level of activity in neural network is maintained after injury-induced activity loss through enhanced network excitability. Read More

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January 2019

Development and validation of a score to detect paroxysmal atrial fibrillation after stroke.

Neurology 2018 Dec 7. Epub 2018 Dec 7.

From the Department of Neurology (T.U., K.G.), and Institute of Medical Biostatistics, Epidemiology and Informatics (G.T., A.J.-E.), University Medical Center of the Johannes Gutenberg University Mainz; Department of Cardiology and Pneumology (M.W.-K.), University of Göttingen; Clinic and Policlinic for Cardiology (R.W.), University Hospital Leipzig, Germany; Department of Neurology (M.G.), Kreisklinikum Siegen; Darmstadt University of Applied Sciences (A.J.-E.); Department of Neurology (M.J.), Hainich Klinikum, Mühlhausen, Germany; Institute of Cardiovascular Sciences (P.K.), University of Birmingham; and Department of Cardiology (P.K.), SWBH and UHB NHS Trusts, Birmingham, UK.

Objective: Prolonged monitoring times (72 hours) are recommended to detect paroxysmal atrial fibrillation (pAF) after ischemic stroke but this is not yet clinical practice; therefore, an individual patient selection for prolonged ECG monitoring might increase the diagnostic yield of pAF in a resource-saving manner.

Methods: We used individual patient data from 3 prospective studies (n = 1,556) performing prolonged Holter-ECG monitoring (at least 72 hours) and centralized data evaluation after TIA or stroke in patients with sinus rhythm. Based on the TRIPOD (Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis) guideline, a clinical score was developed on one cohort, internally validated by bootstrapping, and externally validated on 2 other studies. Read More

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December 2018

Impact of the Cox-Maze IV Procedure on Left Atrial Mechanical Function.

Heart Lung Circ 2018 Nov 30. Epub 2018 Nov 30.

St Vincent's Hospital, Melbourne, Victoria, Australia.

Background: The Cox-Maze IV procedure is a proven surgical treatment for atrial fibrillation (AF). Previous studies on the procedure and its effect on left atrial mechanical function have yielded mixed results.

Methods: Sixty-four patients underwent Cox-Maze IV at St Vincent's Hospital, Melbourne between March 2010 and May 2016. Read More

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November 2018

Health care cost analysis of enhanced pacing modalities in bradycardia patients: Portuguese case study on the results of the MINERVA trial.

Rev Port Cardiol 2018 Dec 6. Epub 2018 Dec 6.

University of Florence, Florence, Italy.

Introduction: The MINERVA trial established that atrial preventive pacing and atrial antitachycardia pacing (DDDRP) in combination with managed ventricular pacing (MVP) reduces progression to permanent atrial fibrillation (AF) in patients with paroxysmal or persistent AF and bradycardia who need cardiac pacing, compared to standard dual-chamber pacing (DDDR). It was shown that AF-related health care utilization was significantly lower in the DDDRP + MVP group than in the control group. Cost analysis demonstrated significant savings related to this new algorithm, based on health care costs from the USA, Italy, Spain and the UK. Read More

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December 2018

Effect of Postablation Statin Treatment on Arrhythmia Recurrence in Patients With Paroxysmal Atrial Fibrillation.

J Cardiovasc Pharmacol 2018 Dec;72(6):285-290

2nd Department of Cardiology, University of Athens Medical School, Attikon Hospital, Athens, Greece.

Background: Statins have been proposed as a means to prevent postablation atrial fibrillation (AF) recurrences, mainly on the basis of their pleiotropic effects. The objective of this subanalysis of a prospectively randomized controlled study population of patients undergoing radiofrequency ablation for paroxysmal AF was to test the hypothesis that statin treatment is associated with longer time to recurrence.

Methods And Results: This is a subanalysis over an extended follow-up period of a prospective randomized study (ClinicalTrials. Read More

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December 2018
2 Reads

Increased Risk of Benign Paroxysmal Positional Vertigo in Patients With Non-Apnea Sleep Disorders: A Nationwide, Population-Based Cohort Study.

J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.

Study Objectives: To investigate the association between non-apnea sleep disorders (NSD) and subsequent benign paroxysmal positional vertigo (BPPV) risk.

Methods: This retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database from 2000 to 2013. We established an NSD group (n = 24,624) and an age-, sex- and index year-matched comparison group (n = 98,496). Read More

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November 2018
2 Reads

Complexities in the Atrial Fibrillation-Stroke Relationship: Improving Comprehension of Temporal Discordance, Magnitude Synergism, and Subclinical Atrial Fibrillation -- Three Sources of Consternation for Physicians Who Care for Patients with Atrial Fibrillation.

Authors:
James A Reiffel

J Atr Fibrillation 2018 Aug 31;11(2):2100. Epub 2018 Aug 31.

Professor Emeritus of Medicine, Columbia University Dept. of Medicine, Division of Cardiology.

That clinically-documented atrial fibrillation (AF) in association with a variety of elevated clinical/laboratory risk markers is associated with an increased risk of stroke is well known -- regardless of whether the AF is paroxysmal, persistent, or permanent. Moreover, data is accumulating to suggest that the absolute rate of stroke should be expectedly higher with a greater burden of AF and greater degree of comorbid contributors. Relatedly, stroke prevention with chronic oral anticoagulation (OAC) is recommended for AF patients with appropriate risk markers by all major medical, cardiologic, and surgical guideline-writing organizations. Read More

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August 2018
1 Read

"Clinical Impact of the Cryoballoon Temperature and Occlusion Status on the Success of Pulmonary Vein Isolation".

J Atr Fibrillation 2018 Aug 31;11(2):2065. Epub 2018 Aug 31.

Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo.

Background: Complete occlusion of the pulmonary veins (PVs) with the cryoballoon (CB) is considered to be the crucial factor for a successful PV isolation (PVI). We investigated whether a complete occlusion was indispensable for a successful CB based PVI of every PV.

Methods And Results: Atrial fibrillation patients (n=123, 97; paroxysmal) undergoing a de novo PVI were enrolled. Read More

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August 2018
1 Read

An Itchy Lead: First Reported Case of Ventricular Pacemaker Lead Self-Extraction.

J Atr Fibrillation 2018 Aug 31;11(2):2052. Epub 2018 Aug 31.

Division of Cardiology, Altru Health System, Grand Forks, North Dakota 58201.

We present a particularly rare case and the first ever report of a ventricular self-extraction in a 98-year old female. Our patient had a past medical history significant for severe Alzheimer's dementia, paroxysmal atrial fibrillation, and sick sinus syndrome who was admitted in clinically stable condition following the unwitnessed self-extraction the ventricular lead of her dual chamber pacemaker. This case highlights the potential risks and other clinical challenges of pacemaker and ICD placement in elderly patients and in patients with cognitive impairment. Read More

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August 2018
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Paroxysmal sympathetic hyperactivity due to fourth ventricular tumor resection resulting in cerebrovascular constriction syndrome.

Neurol India 2018 Nov-Dec;66(6):1821-1822

Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

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December 2018
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A brief, but comprehensive, guide to clonal evolution in aplastic anemia.

Authors:
Daria V Babushok

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):457-466

Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA; and.

Acquired aplastic anemia (AA) is an immune-mediated bone marrow aplasia that is strongly associated with clonal hematopoiesis upon marrow recovery. More than 70% of AA patients develop somatic mutations in their hematopoietic cells. In contrast to other conditions linked to clonal hematopoiesis, such as myelodysplastic syndrome (MDS) or clonal hematopoiesis of indeterminate potential in the elderly, the top alterations in AA are closely related to its immune pathogenesis. Read More

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November 2018
3 Reads

Anticoagulating patients with high-risk acquired thrombophilias.

Authors:
Leslie Skeith

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):439-449

Division of Hematology and Hematological Malignancies, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Canada; and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.

Antiphospholipid syndrome (APS), heparin-induced thrombocytopenia, and paroxysmal nocturnal hemoglobinuria are 3 acquired thrombophilias that carry a high risk of venous and arterial thromboembolism. Management of these conditions has largely included anticoagulation with a vitamin K antagonist after an initial period of a parenteral anticoagulant, for as long as the thrombotic risk is still present. The available evidence for the use of direct oral anticoagulants (DOACs) is limited and primarily consists of case series and cohort studies, which are summarized in this chapter. Read More

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November 2018
1 Read

Complement-driven anemia: more than just paroxysmal nocturnal hemoglobinuria.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):371-376

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Atypical hemolytic uremic syndrome (aHUS); hemolysis, elevated liver function tests, and low platelets syndrome; and transplant-associated thrombotic microangiopathy are related conditions, in that many patients harbor germline heterozygous mutations in genes that regulate the alternative pathway of complement (APC). Penetrance is variable because development of clinically significant disease appears to require supervention of a process such as inflammation. Complement activation on the endothelial surfaces leads to endothelial damage, platelet consumption, microthrombi, and a mechanical hemolytic anemia with schistocytes. Read More

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November 2018
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[Approach to patients with vertigo].

Medicina (B Aires) 2018 ;78(6):410-416

Servicio de Otorrinolaringología, Hospital Británico de Buenos Aires, Argentina.

Vertigo is defined as an abnormal sensation of body motion or of its surrounding objects. It is a common chief complaint in emergency departments comprising 2 to 3% of these consultations worldwide. Vertigo is classified as peripheral or central, according to its origin, and can also be occasionally mixed, the most common cause of peripheral involvement being benign paroxysmal positional vertigo. Read More

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January 2018
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Morphological determinators of platelet activation status in patients with atrial fibrillation.

Int J Cardiol 2018 Nov 17. Epub 2018 Nov 17.

Department of Electrophysiology, Heart Center Leipzig, Germany.

Background: Stage of platelet activation is an important modulator of stroke risk associated with atrial fibrillation (AF). However, factors determining such activation status of thrombocytes in patients with AF are still not well studied.

Methods And Results: We enrolled 83 patients (mean age 61 ± 10 years, 61% male, mean CHADS-VASc 2. Read More

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November 2018
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Secular trends in success rate of catheter ablation for atrial fibrillation: The SMASH-AF cohort.

Am Heart J 2018 Oct 29. Epub 2018 Oct 29.

Department of Medicine, Stanford University School of Medicine, Stanford, CA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA; Center for Digital Health, Stanford University School of Medicine, Stanford, CA. Electronic address:

Background: Approaches, tools, and technologies for atrial fibrillation (AF) ablation have evolved significantly since its inception. We sought to characterize secular trends in AF ablation success rates.

Methods: We performed a systematic review and meta-analysis of AF ablation from January 1, 1990, to August 1, 2016, searching PubMed, Scopus, and Cochrane databases. Read More

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October 2018
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Acute-Onset Ataxia and Transient Cerebellar Diffusion Restriction Associated with a PRRT2 Mutation.

J Stroke Cerebrovasc Dis 2018 Nov 28. Epub 2018 Nov 28.

Neurology Department, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, (AP-HP), Paris, France.

PRRT2 gene mutations cause paroxysmal kinesigenic dyskinesia (PKD), infantile convulsions, hemiplegic migraine, and episodic ataxia. A 21-year-old woman reported an episode of dizziness and ataxic gait occurring after swimming. Brain MRI showed a hyperintense cerebellar lesion on diffusion-weighted imaging (DWI) with decreased apparent diffusion coefficient. Read More

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November 2018
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Paroxysmal Atrial Fibrillation Catheter Ablation of Pulmonary Veins: does Anatomy Influence the Outcome?

Arq Bras Cardiol 2018 Dec;111(6):831-832

Instituto de Cardiologia do Distrito Federal - Fundação Universitária de Cardiologia (FUC), Brasília, DF - Brazil.

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December 2018
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