Search Our Scientific Publications & Authors

Virchows Arch 2022 Jun 24. Epub 2022 Jun 24.

Department of Pathology, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC, Canada.

The Milan system for reporting salivary gland cytopathology (MSRSGC) is a novel standardized classification tool for salivary gland cytology specimens based on the use of direct smears. Formalin-fixed paraffin-embedded (FFPE) cell blocks facilitate the use of ancillary studies, leading to improved diagnostic accuracy. However, the application of the MSRSGC with only cell blocks has not been well established. Read More

Eur Radiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China.

Objectives: To evaluate the effectiveness of machine learning models based on morphological magnetic resonance imaging (MRI) radiomics in the classification of parotid tumors.

Methods: In total, 298 patients with parotid tumors were randomly assigned to a training and test set at a ratio of 7:3. Radiomics features were extracted from the morphological MRI images and screened using the Select K Best and LASSO algorithm. Read More

Front Oncol 2022 7;12:830496. Epub 2022 Jun 7.

Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Purpose: The magnetic resonance imaging (MRI) findings may overlap due to the complex content of parotid gland tumors and the differentiation level of malignant tumor (MT); consequently, patients may undergo diagnostic lobectomy. This study assessed whether radiomics features could noninvasively stratify parotid gland tumors accurately based on apparent diffusion coefficient (ADC) maps.

Methods: This study examined diffusion-weighted imaging (DWI) obtained with echo planar imaging sequences. Read More

J Clin Med 2022 Jun 10;11(12). Epub 2022 Jun 10.

Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Sialolithiasis is the most common cause of calcifications detected with ultrasound in patients with chronic inflammatory symptoms and swellings of the salivary glands. Other differential diagnoses of calcifications are extremely rare and mostly benign. Case report and literature review. Read More

In Vivo 2022 Jul-Aug;36(4):1795-1800

Departments of Radiation Oncology, University of Lübeck, Lübeck, Germany.

Background/aim: Radiotherapy of head-and-neck cancers can cause xerostomia. This study investigated potential prognostic factors for complete recovery from this complication.

Patients And Methods: Eighty head-and-neck cancer patients with radiation-induced xerostomia were retrospectively evaluated. Read More

Metabolites 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.

Salivary gland tumors are relatively uncommon neoplasms that represent less than 5% of head and neck tumors, and about 90% are in the parotid gland. The wide variety of histologies and tumor characteristics makes diagnosis and treatment challenging. In the present study, Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used to discriminate the pathological regions of patient-derived biopsies of parotid neoplasms by metabolomic and lipidomic profiles. Read More

Laryngoscope Investig Otolaryngol 2022 Jun 9;7(3):779-784. Epub 2022 May 9.

Department of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan.

Objective: Lymphoepithelial carcinoma (LEC) accounts for 0.4% of malignant tumors of the salivary gland and 0.8% of parotid gland malignancies. Read More

BMC Oral Health 2022 Jun 17;22(1):239. Epub 2022 Jun 17.

Department of Oncology Radiotherapy, Zhongshan City People's Hospital, No.2 Sunwen Middle Road, Shiqi District, Zhongshan City, 528403, Guangdong, China.

Background: This study was to evaluate the predictors of xerostomia and Grade 3 xerostomia in locoregionally advanced nasopharyngeal carcinoma (NPC) patients receiving radical radiotherapy and establish prediction models for xerostomia and Grade 3 xerostomia based on the predictors.

Methods: Totally, 365 patients with locoregionally advanced NPC who underwent radical radiotherapy were randomly divided into the training set (n = 255) and the testing set (n = 110) at a ratio of 7:3. All variables were included in the least absolute shrinkage and selection operator regression to screen out the potential predictors for xerostomia as well as the Grade 3 xerostomia in locoregionally advanced NPC patients receiving radical radiotherapy. Read More

J Pak Med Assoc 2022 May;72(5):950-953

Department of Surgical Oncology, Lahore,Pakistan.

Mammary Analogue Secretory Carcinoma (MASC) is a rare pathology of the salivary gland, most commonly involving the parotid gland. The objective of this study was to identify the characteristic features of MASC and its treatment outcomes. A retrospective review of 12 patients with histological diagnosis of MASC, who were managed between 2010 to 2019, was carried out at the Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore. Read More

J Cutan Pathol 2022 Jun 16. Epub 2022 Jun 16.

University of Virginia Medical Center, Department of Pathology, P.O. Box 800214, 1215 Lee St, Charlottesville, VA.

Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor characterized by unique histomorphologic and immunohistochemical features as well as recurrent MEF2C::SS18 gene fusion. Since 2019, 24 cases have been reported in the literature, primarily arising in the oral cavity, with a single reported case arising in the parotid gland. Here, we present a case of MSA that arose in the external ear canal in an 89-year-old woman and was discovered during management of vertigo symptoms. Read More

S D Med 2022 Apr;75(4):158-160

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Sebaceous adenocarcinoma of the parotid gland is a rare, malignant epithelial neoplasm with focal areas of sebaceous differentiation. A literature search revealed only 34 cases as of December 2020. Our case brings this total to 35. Read More

Gulf J Oncolog 2022 May;1(39):79-88

Department of Medical Oncology, RCC JIPMER, Puducherry, India.

Extraosseous Ewing's Sarcoma (EES) is a high grade rare malignancy from Ewing's family tumors (EFTs) occurring in soft tissues. Diagnosis of EES relies on a constellation of features, including round cell morphology, characteristic immunohistochemistry (such as CD99, FLI-1 and NKX2.2 positivity), and pathognomic molecular abnormalities of t(11;22)(q24;q12). Read More

World J Clin Cases 2022 May;10(14):4648-4653

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 23000, Anhui Province, China.

Background: Pleomorphic adenoma (PA) is the most common type of salivary gland tumor, and its common sites are parotid gland, sinus, nasal septum and cleft palate. PA is an uncommon benign type of tumor occurring in the breast, and there are few reports of cases in Asia.

Case Summary: An 84-year-old woman found a mass in the upper outer quadrant of the right breast > 1 year ago. Read More

Oral Oncol 2022 Jul 1;130:105937. Epub 2022 Jun 1.

Loyola University Medical Center, Department of Otolaryngology, Maywood, IL, USA.

Purpose: At present, perineural invasion is used as a histologic indicator of aggressive salivary gland disease. In other head and neck malignancies, perineural invasion impacts staging of cancer lesions and therefore affects treatment options.

Objective: To compare survival outcomes in primary parotid malignancies with and without perineural invasion. Read More

Int J Surg Case Rep 2022 May 30;94:107135. Epub 2022 Apr 30.

Reconstructive Sciences Unit, Hospital Universiti Sains Malayisa, Jalan Raja Perempuan Zainab II, Kubang Kerian, 16150 Kota Bharu, Kelantan, Malaysia. Electronic address:

Introduction: Primary cutaneous anaplastic large cell lymphomas (PC-ALCL) are rare. They fall within non-Hodgkin's lymphomas spectrum. Commonly misdiagnosed, this malignancy involving the skin has favorable prognosis. Read More

Acta Oncol 2022 Jul 3;61(7):856-863. Epub 2022 Jun 3.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.

Purpose: We tested the hypothesis that gene expressions from biopsies of locally advanced head and neck squamous cell carcinoma (HNSCC) patients can supplement dose-volume parameters to predict dysphagia and xerostomia following primary radiochemotherapy (RCTx).

Material And Methods: A panel of 178 genes previously related to radiochemosensitivity of HNSCC was considered for nanoString analysis based on tumour biopsies of 90 patients with locally advanced HNSCC treated by primary RCTx. Dose-volume parameters were extracted from the parotid, submandibular glands, oral cavity, larynx, buccal mucosa, and lips. Read More

Iran J Otorhinolaryngol 2022 Mar;34(121):83-88

Nuclear Medicine Physician, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Patotidectomy is the treatment of choice for superficial parotid gland lesions. The present study aimed to assess the facial nerve status, as well as peri-and postsurgical complications, in two surgical techniques (antegrade and retrograde) for parotidectomy.

Materials And Methods: This study was conducted on 56 patients diagnosed with parotid neoplasms from 2013-2015. Read More

Tex Heart Inst J 2022 05;49(3)

Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

A 64-year-old man who had undergone treatment for left parotid adenocarcinoma presented with progressive exertional shortness of breath. Evaluation revealed metastatic invasion of the myocardium as a rare presentation of recurrent parotid adenocarcinoma. This case highlights the importance of using multimodal imaging methods in diagnostic evaluation and a collaborative multidisciplinary approach in managing patient care. Read More

J Cancer Res Ther 2022 Apr;18(2):470-475

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Haidian Dist, Beijing, People's Republic China.

Purpose: Variability in volume delineation is a possible error source in brachytherapy. This study assessed the interobserver variations in clinical target volume (CTV) delineation in postoperative adjuvant I seed implant brachytherapy after parotid gland cancer surgical resection and evaluated the image fusion technique for target volume delineation.

Material And Methods: Five radiation oncologists delineated gross tumor volume (GTV) and CTV in 20 patients using conventional delineation and image fusion methods. Read More

Anticancer Res 2022 Jun;42(6):3035-3039

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Xerostomia is a serious complication following radiotherapy of head-and-neck cancers. A prognostic tool was developed for estimating its risk.

Patients And Methods: In our previous study, age, tumor site, bilateral lymph node involvement, definitive radiotherapy, and addition of systemic therapies showed significant associations with grade ≥3 late xerostomia or trends. Read More

BMJ Case Rep 2022 May 31;15(5). Epub 2022 May 31.

Surgical Oncology, Kolhapur Cancer Centre, Kolhapur, Maharashtra, India.

Malignant neoplasms of salivary gland neoplasms are rare and often involve the parotid gland. The primary treatment of these malignancies is surgery with or without adjuvant therapy. Chemotherapy or systemic therapy is indicated in recurrent or metastatic disease where surgery or radiotherapy is not possible. Read More

Cancer Cytopathol 2022 May 31. Epub 2022 May 31.

Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA.

Background: Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. In this study, the author undertook analysis of a large collection of MEC cytologic cases.

Materials And Methods: Cytopathology files were searched for MEC cases with histopathologic confirmation. Read More

Int J Oral Maxillofac Surg 2022 May 24. Epub 2022 May 24.

Department of Oral Health Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Department of Oral and Maxillofacial Surgery, Sint-Elisabeth Hospital, Tilburg, the Netherlands.

Improvements in preoperative diagnostics and intraoperative techniques have made the surgical excision of benign parotid gland tumours less invasive. Extracapsular dissection (ECD) has become more popular in comparison to superficial parotidectomy (SP), the gold standard. Although clinical outcomes have been reported, reports on cost-effectiveness are limited. Read More

Head Neck Pathol 2022 May 27. Epub 2022 May 27.

Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK.

Background: Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only.

Methods: This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. Read More

Oral Oncol 2022 Jul 23;130:105930. Epub 2022 May 23.

Radiation Oncology, UPMC Hillman Cancer Center, Williamsport, PA, USA; Radiation Oncology, WellSpan Health, Chambersburg, PA, USA. Electronic address:

Clin Ter 2022 May;173(3):203-206

U.O. Maxillofacial Surgery, S. Andrea Hospital, Faculty of medicine and psychology, University of Rome "Sapienza", Roma, Italy.

Abstract: In this paper we report the rare case of a patient who came to our attention with three synchronous Warthin tumours affecting both the right and left parotid glands. The patient was a 68-year-old female, heavy smoker, with a seven-year history of painless growing nodules in both pre-auricular areas. Left-sided subtotal parotidectomy and contralateral superficial parotidectomy were performed at two differ-ent surgical times. Read More

J Oncol 2022 12;2022:8192999. Epub 2022 May 12.

Department of Ultrasound, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, 350014 Fujian Province, China.

Objectives: Evidence suggests that about 80% of all salivary gland tumors involve the parotid glands, with approximately 20% of parotid gland tumors (PGTs) being malignant. Discriminating benign and malignant parotid gland lesions preoperatively is vital for selecting the appropriate treatment strategy. This study explored the diagnostic performance of deep learning system for discriminating benign and malignant PGTs in ultrasonography images and compared it with radiologists. Read More

Eur Arch Otorhinolaryngol 2022 May 21. Epub 2022 May 21.

Department of Radiology, Inonu University Faculty of Medicine, Malatya, Turkey.

Purpose: To create a new artificial intelligence approach based on deep learning (DL) from multiparametric MRI in the differential diagnosis of common parotid tumors.

Methods: Parotid tumors were classified using the InceptionResNetV2 DL model and majority voting approach with MRI images of 123 patients. The study was conducted in three stages. Read More

Radiother Oncol 2022 07 15;172:91-98. Epub 2022 May 15.

Department of Radiation Oncology, First Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address:

Purpose: To identify the clinical significance of sparing submandibular glands (SMG) for the amelioration of acute xerostomia using diffusion kurtosis imaging (DKI) in nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy (HT).

Materials And Methods: The prospective study enrolled 42 participants treated with HT. All patients underwent five times of DKI scans before HT (pre-HT), in the middle of the HT course (mid-HT), immediately after HT (post-HT), and 1 months (1m-HT), 3 months post-HT(3m-HT). Read More

HNO 2022 May 17. Epub 2022 May 17.

Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Universitätsklinikum Erlangen-Nürnberg, Waldstr. 1, 91054, Erlangen, Deutschland.

Background: Due to the rarity of primary parotid malignancies, there are currently only limited clinical study data on the optimal surgical therapy. Parotid malignancies encompass a broad spectrum of more than 20 different histological subtypes with varying biology, which thus represents a challenge for even experienced pathologists and head and neck surgeons with proven expertise in salivary gland surgery.

Objective: The aim of this review article is to provide an overview of the current literature on surgical therapy of the primary tumor and the cN0 neck as well as treatment of the facial nerve, and to shed light on the various controversial aspects of this topic. Read More