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Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Oral and Maxillofacial Surgery, 8AFDC, Kanpur, India.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Pathology, The Ministry of Health Izmir Tepecik Training and Research Hospital, Izmir, Turkey.

Intraparotid facial nerve schwannoma (IFNS) is rarely observed in children compared with adults. Only a few cases have been reported in the literature. After radiological imaging and fine needle aspiration biopsy, an IFNS diagnosis may be skipped and confused with pleomorphic adenoma, which has a high prevalence among patients who have a mass in the parotid gland. Read More

Med Phys 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Purpose: The goal of this study was to generate a large treatment plan database for head-and-neck (H&N) cancer patients that can be considered as golden standard to train and validate models for knowledge-based (KB) treatment planning and QA. With this dataset the intrinsic prediction performance, the effect of inter-organ dependency and the impact of dataset inconsistency was investigated for an existing treatment planning QA model.

Methods: CT-scans of 108 previously treated oropharyngeal patients were used to establish the plan database. Read More

Med Phys 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns, Hopkins University, Baltimore, MD, 21287, USA.

Purpose: In radiotherapy, it is necessary to characterize dose over the patient anatomy to target areas and organs at risk. Current tools provide methods to describe dose in terms of percentage of volume and magnitude of dose, but are limited by assumptions of anatomical homogeneity within a region of interest (ROI) and provide a non-spatially aware description of dose. A practice termed radio-morphology is proposed as a method to apply anatomical knowledge to parametrically derive new shapes and substructures from a normalized set of anatomy, ensuring consistently identifiable spatially-aware features of the dose across a patient set. Read More

Eur Arch Otorhinolaryngol 2018 Dec 1. Epub 2018 Dec 1.

Department of Otolaryngology-HNS, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University School of Medicine, 83 Fenyang Road, Shanghai, 200031, China.

Purpose: To report 5-year survival in patients with primary parotid malignant tumours and assess the impact of various factors on survival or local control among diverse histologic groups.

Methods: A total of 65 patients with primary parotid malignant tumours who had surgery between 2003 and 2014 were identified. Demographic characteristics including age, T stage, N stage and clinical or pathological performance were analysed. Read More

World J Nucl Med 2018 Oct-Dec;17(4):302-304

Department of Nuclear Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.

We are presenting the first case of a gastro-oesophageal junction adenocarcinoma with metastasis only to the intraparotid lymph node simulating Warthin's tumor. A 66-year-old man underwent an esophagogastroduodenoscopy that found circumferential ulcerated esophageal tumor beginning 40 cm from incisors resulting in stricture and two discrete erosions in the proximal third of esophagus. Biopsies from the stricture have demonstrated a poorly differentiated gastric adenocarcinoma. Read More

J Comp Pathol 2018 Nov 24;165:52-56. Epub 2018 Oct 24.

Department of Microbiology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, Japan.

A 7-year-old male cavalier King Charles spaniel was presented with a cervical subcutaneous mass. The mass had a multilobular growth pattern and each individual lobule contained ductal epithelial cells and myoepithelial cells surrounding the ductal cells. Immunohistochemically, the ductal epithelial cells were positive for cytokeratin (CK) 7 and CAM5. Read More

Eur J Rheumatol 2018 Mar;5(1):62-64

Department of Rheumatology, Fırat University School of Medicine, Elazığ, Turkey.

Swelling in the salivary glands, particularly parotid glands, is observed in approximately one third of Sjögren's syndrome patients. However, such patients should be assessed in terms of causes such as malignancies, infections, amyloidosis, sarcoidosis, and other autoimmune diseases when parotid gland swelling is noted. It should be considered that the incidence of lymphoma increases in Sjögren's syndrome. Read More

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

Dipartimento di Scienze Radiologiche, Radioterapiche ed Ematologiche, Istituto di Medicina Nucleare, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Rome, Italy.

A 75-year-old man, who had been diagnosed with small lymphocytic lymphoma with cervical localization, underwent F-FDG PET/CT with iodinated contrast medium due to the appearance of cervical swelling suspected of illness relapse. PET/CT revealed intense F-FDG uptake in multiple cervical and subdiaphragmatic lymph nodes and in the left parotid. Moreover, diffuse uptake and wall thickening of the colon were evident; endoscopy with biopsy revealed a diffuse large B-cell lymphoma. Read More

Radiat Oncol 2018 Dec 4;13(1):240. Epub 2018 Dec 4.

Department of Radiation Oncology, Beaumont Health System, Royal Oak, MI, USA.

Background: Advanced clinical applications, such as dose accumulation and adaptive radiation therapy, require deformable image registration (DIR) algorithms capable of voxel-wise accurate mapping of treatment dose or functional imaging. By utilizing a multistage deformable phantom, the authors investigated scenarios where biomechanical refinement method (BM-DIR) may be better than the pure image intensity based deformable registration (IM-DIR).

Methods: The authors developed a biomechanical-model based DIR refinement method (BM-DIR) to refine the deformable vector field (DVF) from any initial intensity-based DIR (IM-DIR). Read More

Iran J Med Sci 2018 Nov;43(6):668-670

Department of General Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Benign lymphoepithelial cysts of the parotid are common in retropositive patients, but extremely rare in HIV-negative individuals. We present a 28-year-old man who presented with a painless, gradually increasing swelling in the left parotid region and was clinically diagnosed to have a pleomorphic adenoma of the left parotid gland. Preoperative blood investigations revealed that the patient was seronegative. Read More

J Am Dent Assoc 2018 Dec;149(12):1073-1080

Background And Overview: Cone-beam computerized tomographic (CBCT) imaging is increasingly used in the maxillofacial region for various purposes. The volumetric dataset created by means of CBCT increases the possibility of detecting incidental findings.

Case Description: In this case report, the authors describe an otherwise healthy 45-year-old man who was referred from the Sjogren's Syndrome Center in Jerusalem, Israel, for bilateral parotid CBCT sialographic imaging owing to xerostomia lasting for 4 months. Read More

Lond Med Phys J 1830 Jan;8(43):26

Med Phys J 1809 Sep;22(127):221-223

Clayfield Hill, near Rotheram.

Arch Oral Biol 2018 Nov 20;98:148-155. Epub 2018 Nov 20.

Institute of Chemistry of the Molecular Recognition - CNR, L.go F. Vito 1, 00168, Rome, Italy.

Objective: In the present study the salivary proteome of burning mouth syndrome patients and healthy subjects was characterized by a top-down proteomic approach and compared to highlight possible qualitative and quantitative differences that may give suggestions about the causes of this pathology which are still unknown.

Materials And Methods: Resting and stimulated whole saliva, stimulated parotid and submandibular/sublingual saliva samples were collected from burning mouth syndrome patients (n = 16) and age- and gender-matched healthy subjects (n = 14). An equal volume of 0. Read More

JAMA Oncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill.

Importance: Whole-brain radiation therapy (WBRT) delivers a substantial radiation dose to the parotid glands, but the parotid glands are not delineated for avoidance and xerostomia has never been reported as an adverse effect. Minimizing the toxic effects in patients receiving palliative treatments, such as WBRT, is crucial.

Objective: To assess whether xerostomia is a toxic effect of WBRT. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1428-1430

Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Acinic cell carcinoma (AciCC) is a low-grade malignancy which rarely metastasizes to bone or cavernous sinuses. A 62-year-old male patient, previously treated for AciCC of right parotid with surgery and local radiotherapy, presented 10 years later with progressive visual impairment and restriction of ocular movements. Magnetic resonance imaging of the head and orbit showed an expansile lobulated mass with heterogeneous signal intensity in bilateral cavernous sinus with encasement of the internal carotid artery on both sides. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1220-1224

Department of Radiotherapy and Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Aims And Objectives: This study aims to study the effect of geometric- and patient-related variables in achieving the desired dose-volume constraints to parotid for patients undergoing definitive/adjuvant intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinomas (HNSCC).

Subjects And Methods: This retrospective study considered HNSCC patients who underwent IMRT at our center between 2009 and 2014. Patients' details and dose-volume parameters were collected, and correlated with dose to parotids using Pearson's correlation test. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1196-1201

Department of Radiotherapy, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Parotid-sparing intensity-modulated radiotherapy (IMRT) effectively reduces xerostomia in head-and-neck cancer (HNC). Changes in the salivary output at 1 year were studied and correlation with quality of life (QOL) changes in patients of locally advanced HNC (LAHNC) was drawn.

Materials And Methods: Between October 2009 and October 2011, 20 patients of LAHNC were treated with IMRT using simultaneous integrated boost technique. Read More

Bull Math Biol 2018 Nov 27. Epub 2018 Nov 27.

Department of Mathematics, The University of Auckland, Level 2, Building 303, 38 Princes Street, Auckland, New Zealand.

Salivary gland acinar cells use the calcium ([Formula: see text]) ion as a signalling messenger to regulate a diverse range of intracellular processes, including the secretion of primary saliva. Although the underlying mechanisms responsible for saliva secretion are reasonably well understood, the precise role played by spatially heterogeneous intracellular [Formula: see text] signalling in these cells remains uncertain. In this study, we use a mathematical model, based on new and unpublished experimental data from parotid acinar cells (measured in excised lobules of mouse parotid gland), to investigate how the structure of the cell and the spatio-temporal properties of [Formula: see text] signalling influence the production of primary saliva. Read More

Oral Radiol 2018 Sep 8;34(3):277-280. Epub 2017 Sep 8.

Division of Oral and Maxillofacial Radiology, Kyushu Dental University, Kitakyushu, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.

A Stafne bone defect is a static bone depression in the mandible that is commonly observed in cortical bone near the mandibular angle. We herein present a rare case in which static bone depressions attached to the three major salivary glands were observed on panoramic radiography and computed tomography (CT). The three static bone depressions in the mandible were visualized on a panoramic radiograph and CT as oval radiolucent masses in a 68-year-old man. Read More

Oral Radiol 2018 Sep 12;34(3):267-272. Epub 2017 Jun 12.

Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, 52 Mária Street, Budapest, 1085, Hungary.

We report a rare case of Sjögren's syndrome (SS) with multiple microliths in the bilateral parotid glands. A 41-year-old man presented to our department with mild pain in the region of the right parotid gland. The dental examination was negative except for the parotid regions. Read More

Surg Radiol Anat 2018 Nov 27. Epub 2018 Nov 27.

Department II of Surgical Clinical Divisions, Faculty of Medicine, "Ovidius" University, Constanţa, Romania.

The external carotid artery (ECA) normally bifurcates terminally with the superficial temporal artery (STA) and the maxillary artery (MA). From the horizontally coursing, mandibular segment of the MA leaves the middle meningeal artery (MMA). We hereby report a previously unknown anatomic possibility, incidentally found during an angio-CT scan in an adult female patient. Read More

Shanghai Kou Qiang Yi Xue 2018 Aug;27(4):411-414

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Huzhou University. Huzhou 313000,Zhejiang Province, China.

Purpose: To investigate the clinical features, diagnosis, and treatment, as well as prognosis of neurinoma in parotid region, in order to provide references for clinical treatment.

Methods: Fifty-two cases of neurinoma in parotid region treated between June 2000 to December 2013 were retrospectively investigated, including their clinical characteristics, imaging examination, diagnosis, therapies and prognosis. SPSS13. Read More

OTO Open 2017 Jul-Sep;1(3):2473974X17719416. Epub 2017 Jul 3.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Med Phys 2018 Nov 27. Epub 2018 Nov 27.

Department of Computer Science, University of California, Irvine, CA, USA.

Purpose: Radiation therapy (RT) is a common treatment option for head and neck (HaN) cancer. An important step involved in RT planning is the delineation of organs-at-risks (OARs) based on HaN computed tomography (CT). However, manually delineating OARs is time-consuming as each slice of CT images needs to be individually examined and a typical CT consists of hundreds of slices. Read More

Ann Med Surg (Lond) 2018 Dec 8;36:148-151. Epub 2018 Nov 8.

Department of Clinical Surgical Science, University of the West Indies, St. Augustine, Trinidad and Tobago.

Objective: The epidemiology of the salivary glands tumour is not well documented in the Caribbean countries. Therefore, the aim of this study is to determine the local trend of salivary gland tumours with a review of current diagnostic techniques.

Design & Methods: Retrospective data was collected from the electronic database at the Pathology department of the San Fernando Teaching Hospital between the periods January 2005 to June 2015. Read More

Head Neck 2018 Nov 26. Epub 2018 Nov 26.

Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Alterations in the human epidermal growth factor receptor-2 (HER2) pathway have been identified in a subset of salivary duct carcinomas. Dual HER2 inhibition with trastuzumab and pertuzumab has superior antitumor efficacy to trastuzumab monotherapy in HER2-positive breast cancer, yet its efficacy in HER2-positive salivary duct carcinoma is unknown.

Methods: We report 2 cases of exceptional responses of HER2-positive salivary duct carcinomas to dual HER2 blockade and docetaxel combination and their molecular characteristics. Read More

J Exp Ther Oncol 2018 Nov;12(4):307-315

Department of Pathology, PostGraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Objective: Although mucoepidermoid carcinoma is the most common primary malignancy of the salivary glands, the sclerosing morphologic variant of this tumor is extremely rare and only 26 cases have been reported till date in the english literature. This report describes a case involving a 35-year-old female with an intermediate-grade sclerosing mucoepidermoid carcinoma of parotid gland and we review the litreture. Immunohitochemical markers, Her-2/neu and MIB-1 evaluated to help predict the clinical outcome and to determine whether an association exists between the histologic grade and immunohistochemical findings. Read More

J Magn Reson Imaging 2018 Nov 26. Epub 2018 Nov 26.

Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Department of Radiology, Shanghai, P.R. China.

Background: Differential diagnosis of the mucosa-associated lymphoid tissue lymphoma (MALToma) and tumor-like benign lymphoepithelial lesion (BLEL) in the parotid gland is difficult.

Purpose: To distinguish MALToma and BLEL with multimodality MRI including hydrogenproton magnetic resonance spectroscopy ( H-MRS), diffusion-weighted imaging (DWI-MR), and dynamic contrast-enhanced (DCE-MR), and evaluate each sequence.

Study Type: Retrospective. Read More

Case Rep Oncol Med 2018 24;2018:4038250. Epub 2018 Oct 24.

Sri Venkateshwaraa Medical College Hospital & Research Centre, Department of Radiology, Puducherry, India.

Follicular dendritic cell sarcoma is a very rare neoplasm that most commonly involves cervical lymph nodes and usually presents as a solid mass. Presentation as a cystic neck mass is very rare. Radiological studies and aspiration cytology are often unreliable, and diagnosis is usually made after thorough clinical and pathological examination along with immunohistochemical analysis. Read More

Oxid Med Cell Longev 2018 24;2018:7083486. Epub 2018 Oct 24.

Department of Experimental Pharmacology, Medical University of Białystok, ul. Szpitalna 37, 15-295 Białystok, Poland.

Oxidative stress takes part in the pathomechanisms of many diseases, including oral disorders. The imbalance between oxidative and antioxidative processes may lead to periodontitis, osteitis, or oral cancers. Furthermore, many chemotherapeutics, e. Read More

Med Sci Monit 2018 Nov 25;24:8500-8505. Epub 2018 Nov 25.

Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).

BACKGROUND This study aimed to investigate the therapeutic role of flattening filter-free (FFF) mode in volumetric modulated arc therapy (VMAT) compared with flattening filter (FF) mode in patients with locally advanced nasopharyngeal carcinoma (NPC). MATERIAL AND METHODS Ten previously treated patients with NPC underwent treatment re-planning with FFF and FF VMAT. Radiotherapy dose distribution on planning target volume (PTV), organs at risk (OAR), target conformity index (CI), total monitor units (MUs), and therapeutic time were compared. Read More

Phys Med 2018 Nov 15;55:107-115. Epub 2018 Nov 15.

Department of Medical Sciences, University of Girona, C/Emili Grahit 77, 17003 Girona, Spain; Department of Radiology, Clínica Girona, Institut de Diagnòstic per la Imatge, C/Lorenzana 36, 17002 Girona, Spain. Electronic address:

Purpose: To assess the dosimetric impact of switching from the Analytical Anisotropic Algorithm (AAA) to Acuros XB (AXB) for both dose-to-medium (Dm) and dose-to-water (Dw) in VMAT for H&N patients. To study whether it should be linked to a change in the dose prescriptions to the PTVs and in the constraints to the OARs.

Methods: 110H&N patients treated with VMAT were included. Read More

Radiat Oncol 2018 Nov 23;13(1):229. Epub 2018 Nov 23.

Beatson West of Scotland Cancer Centre, Radiotherapy Physics, NHS Greater Glasgow and Clyde, 1053 Great Western Road, Glasgow, G12 0YN, UK.

Background: A new strategy is introduced combining the use of Multi-Criteria Optimization-based Trade-Off Exploration (TO) and RapidPlan™ (RP) for the selection of optimisation parameters that improve the trade-off between sparing of organs at risk (OAR) and target coverage for head and neck radiotherapy planning. Using both approaches simultaneously; three different workflows were proposed for the optimisation process of volumetric-modulated arc therapy (VMAT) plans. The generated plans were compared to the clinical plans and the plans that resulted using RP and TO individually. Read More

Ann Anat 2018 Nov 22;222:70-78. Epub 2018 Nov 22.

Department of Biological and Material Sciences in Dentistry, School of Dentistry, Faculty of Health, Witten/Herdecke University, Germany. Electronic address:

Introduction: The superficial musculoaponeurotic system (SMAS) of the midface has a complex morphological architecture, and a multitude of controversial opinions exist regarding its in vitro appearance and clinical relevance. The aim of this study was to investigate the three-dimensional architecture of the midfacial SMAS.

Method: Histological and SEM analyses were performed on tissue blocks of the skin, subcutaneous tissue and mimic musculature of the midfacial region between the anterior parotid gland pole and lateral to the nasolabial fold and tissue blocks of the skin, subcutaneous tissue and parotid fascia. Read More

Clin Case Rep 2018 Nov 23;6(11):2126-2130. Epub 2018 Sep 23.

Department of Radiation Oncology MD Anderson Cancer Center Houston Texas.

This study highlights gamma knife stereotactic radiosurgery (GK-SRS) as boost therapy in a patient with adenoid cystic carcinoma of the parotid involving the skull base and invasion of the facial nerve. Using GK-SRS, dose to the brainstem and temporal lobe were reduced when compared to less conformal radiotherapy techniques. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;53(11):857-858

Department of Otorhinolaryngology, Zhifu Branch of Yuhuangding Hospital, Yantai 264000, China.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan.

A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Read More

Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):125-144

Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical School, Parkland Memorial Hospital, 5323 Harry Hines Boulevard, Mail Code 9109, Dallas, TX 75390, USA.

Salivary gland tumors are rare pathologic entities that are derived from major and minor salivary gland tissue located throughout the head and neck region. These tumors are distinctly heterogenous, comprising numerous cell types, especially those deemed malignant. The incidence of malignant salivary gland tumors is widely distributed in both adult and pediatric patient populations. Read More

J Otolaryngol Head Neck Surg 2018 Nov 16;47(1):69. Epub 2018 Nov 16.

Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.

Background: Secretory Carcinoma (SC) is a recently described malignancy affecting salivary glands of the head and neck, with a paucity of evidence regarding the natural history, morbidity, and mortality. This study aimed to investigate the current treatment options utilized for SC, as well as its presentation and outcomes.

Methods: This study is a retrospective case series and includes patients diagnosed with SC at four Maritime Canadian institutions. Read More

Laryngoscope 2018 Nov 16. Epub 2018 Nov 16.

Department of Clinical Sciences, Simmons Comprehensive Cancer Center , University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.

Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes.

Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Read More

Auris Nasus Larynx 2018 Nov 12. Epub 2018 Nov 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hirhoshima-shi, Hiroshima, 734-8551, Japan.

CheckMate 141, an open-label, randomized phase III trial of nivolumab, indicated that treatment with nivolumab prolonged overall survival of patients with platinum-refractory, recurrent head and neck squamous cell carcinoma. Herein, we describe a case of brain metastasis of parotid carcinoma in which a good response was achieved after nivolumab treatment. The patient was a 67-year-old woman with parotid carcinoma (cT4bN0M0) who received induction chemotherapy followed by chemoradiation. Read More

Am J Phys Med Rehabil 2018 Dec;97(12):873-878

From the Children's Specialized Hospital, Clifton, New Jersey (HAS); Touro College, Executive Office, New York, New York (EA); Cornell University Joan and Sanford I Weill Medical College, New York, New York (AH); New York-Presbyterian Hospital, New York, New York (XW, PT, RA, HK); and Blythedale Children's Hospital, New York, New York (XW, PT, RA, HK).

Objective: The aim of the study was to investigate the safety and efficacy of onabotulinum toxin A injection to the salivary glands under ultrasound guidance for the treatment of sialorrhea in patients with spinal muscular atrophy type I.

Design: Prospective case series with four patients with spinal muscular atrophy type I who received onabotulinum toxin A injection to parotid and submandibular glands for sialorrhea as part of clinical care. All four patients received validated surveys for measuring drooling, including objective measures of number of bib changes, and number of mouth wipes before injection and 4-6 wks after injection. Read More

Laryngoscope 2018 Nov 15. Epub 2018 Nov 15.

Department of Otolaryngology and Communication Enhancement, Boston, Massachusetts, U.S.A.

Objective: Pleomorphic adenoma is the most common benign salivary gland neoplasm in children. Recurrence and malignant transformation are concerns necessitating proper treatment. The goal of this research was to discuss the presentation, evaluation, and management of pediatric pleomorphic adenoma of the head and neck. Read More

World J Clin Cases 2018 Nov;6(13):707-715

Department of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.

IgG4-related disease (IgG4-RD) is an increasingly recognized pathological entity that tends to involve multiple organs with an elevated level of serum IgG4, which is easily misdiagnosed owing to sharing common clinical features with a variety of other diseases. Here, we report an interesting IgG4-RD case of a woman with progressive multi-organ involvement for over 19 years, started with swollen eyelids, dry eye and mouth, and polydipsia and hydruria. Imaging diagnosis revealed diffuse enlargement of the parotid glands, enlargement of the head of the pancreas, pulmonary infection and interstitial lung. Read More