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    1 OF 28

    LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations.
    J Clin Oncol 2012 Jun;30(18_suppl):LBA7500
    Massachusetts General Hospital Cancer Center, Boston, MA.
    LBA7500 Background: Afatinib (A) is a selective, orally bioavailable, irreversible ErbB family blocker of EGFR (ErbB1), HER2 (ErbB2), and ErbB4. This global study investigated the efficacy and safety of A compared with pemetrexed/cisplatin (PC) in pts with EGFR mutation positive advanced lung adenocarcinoma.

    Methods: Following central testing for EGFR mutations (companion diagnostic TheraScreen EGFR RGQ PCR kit), 345 pts (stage IIIB/IV, PS 0-1, chemo-naive) were randomized 2:1 (A: 230; PC: 115) to daily A 40 mg or iv PC (500 mg/m(2) + 75 mg/m(2) q21 days up to 6 cycles). Read More

    Chemotherapy-associated paronychia treated with 2% povidone-iodine: a series of cases.
    Cancer Manag Res 2017 26;9:225-228. Epub 2017 Jun 26.
    Veloce BioPharma LLC, Fort Lauderdale, FL.
    Background: Nail changes are known to occur during the use of chemotherapy for a variety of malignancies, particularly those treated with taxanes and EGFR inhibitors. There are currently no actively recruiting prospective clinical trials investigating potential treatments. There are also no US Food and Drug Administration-approved medical treatments for chemotherapy-associated paronychia and no consensus on the best way to treat these common chemotherapy-induced events. Read More

    Neonatal Acute Paronychia.
    Hand (N Y) 2017 Feb 1:1558944717692092. Epub 2017 Feb 1.
    1 West Virginia University School of Medicine, Morgantown, USA.
    Background: Paronychia is defined as infection afflicting the eponychial nail folds of the hand or foot. Such infections are rarely reported in the perinatal age group, and not previously described in a neonate younger than 2 weeks. Trauma resulting in inoculation of the nail fold is the most common predisposing factor to paronychia. Read More

    Acute and Chronic Paronychia.
    Am Fam Physician 2017 Jul;96(1):44-51
    Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
    Paronychia is inflammation of the fingers or toes in one or more of the three nail folds. Acute paronychia is caused by polymicrobial infections after the protective nail barrier has been breached. Treatment consists of warm soaks with or without Burow solution or 1% acetic acid. Read More

    Recurrent Paronychia as a Presenting Manifestation of Pemphigus Vulgaris: A Case Report.
    Skin Appendage Disord 2017 Mar 19;3(1):28-31. Epub 2017 Jan 19.
    Skin Disease Centre, Nashik, India.
    Nail involvement in pemphigus vulgaris (PV) is an unusual clinical finding. The most common clinical manifestations include chronic paronychia and onychomadesis. We report an adult female patient with PV who initially presented with chronic paronychia of multiple fingernails and toenails before the onset of vesiculobullous eruptions. Read More

    Osimertinib: A third-generation tyrosine kinase inhibitor for treatment of epidermal growth factor receptor-mutated non-small cell lung cancer with the acquired Thr790Met mutation.
    J Oncol Pharm Pract 2017 Jan 1:1078155217712401. Epub 2017 Jan 1.
    1 Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
    Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved for the treatment of metastatic EGFR T790M mutation-positive non-small cell lung cancer (NSCLC) in patients failing previous TKI therapy. The T790M mutation is an acquired resistance mechanism found in over half of patients with NSCLC progressing on first-generation TKIs. First- and second-generation TKIs do not inhibit the T790M mutation at clinically relevant concentrations. Read More

    Acute finger-tip infection: Management and treatment. A 103-case series.
    Orthop Traumatol Surg Res 2017 May 26. Epub 2017 May 26.
    Centre de la main, chirurgie de la main, 47, rue de la Foucaudière, 49800 Trélaze, France.
    Introduction: Acute fingertip infections (AFTI) are common. Surgical treatment is the norm in case of effusion. There is, however, no consensus on treatment modalities, or on adjuvant antibiotic therapy (AT). Read More

    Periungual tegumentary leishmaniasis: a diagnostic challenge.
    An Bras Dermatol 2017 Mar-Apr;92(2):268-269
    Department of Clinical Medicine, Dermatology Unit, of the School of Medical Sciences of the State University of Campinas (Unicamp) - Campinas (SP), Brazil.
    Periungual and paronychia-like skin lesions can mimic various diseases, setting up a diagnostic challenge that invariably requires correlation with complementary tests. We report a case of an ulcerated tumor of the nailfold diagnosed as leishmaniasis. Although paronychia-like cutaneous leishmaniasis is a rare variant, its epidemiological relevance in Brazil should prompt dermatologists to include it as a plausible diagnosis thus leading to correct work up and treatment. Read More

    Microbiological analysis of acute infections of the nail fold on the basis of bait thread test.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):110-115. Epub 2017 Apr 13.
    Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: An acute infection of the nail fold, called paronychia, is a common clinical problem. The basis for the implementation of the treatment is the result of microbiological examination. Due to the rapid and painful course of infection, usually an empirical antimicrobial treatment prior to obtaining microbiological test results is introduced. Read More

    A prospective randomized controlled trial of hydrating nail solution for prevention or treatment of onycholysis in breast cancer patients who received neoadjuvant/adjuvant docetaxel chemotherapy.
    Breast Cancer Res Treat 2017 Aug 9;164(3):617-625. Epub 2017 May 9.
    Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
    Purpose: Onycholysis and other nail toxicities occur in approximately 20-30% of breast cancer (BC) patients receiving docetaxel chemotherapy. Onycholysis is often associated with painful paronychia, decreasing patients' quality of life. In this study, we aimed to evaluate the efficacy of hydrating nail solution (HNS) (EVONAIL(®) solution, Evaux Laboratories, France) for the prevention and treatment of docetaxel-induced onycholysis and nail toxicities. Read More

    Ethnopharmacological survey of medicinal plants practiced by traditional healers and herbalists for treatment of some urological diseases in the West Bank/Palestine.
    BMC Complement Altern Med 2017 May 8;17(1):255. Epub 2017 May 8.
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, P.O. Box 7, Palestine.
    Background: Throughout history, every civilization in the world used plants or their derivatives for treatment or prevention of diseases. In Palestine as in many other countries, herbal medicines are broadly used in the treatment of wide range of diseases including urological diseases. The main objective of this research is to study the use of herbal remedies by herbalists and traditional healers for treatment of various urological diseases in the West Bank regions of Palestine and to assess their efficacy and safety through the literature review of the most cited plants. Read More

    Management of epidermal growth factor receptor tyrosine kinase inhibitor-related cutaneous and gastrointestinal toxicities.
    Asia Pac J Clin Oncol 2017 May 2. Epub 2017 May 2.
    Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore.
    Patients with advanced stage non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations using EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib, gefitinib and afatinib as first-line treatment had better progression-free survival, overall response rate and quality of life than those on chemotherapy. Although EGFR TKIs are commonly associated with skin-related (rash, xerosis and paronychia) and gastrointestinal-related (diarrhea and stomatitis) adverse events (AEs), these effects are usually mild. But severe cases can occur, significantly affecting patient's well-being, treatment compliance and quality of life. Read More

    Second-line Treatment of Non-Small Cell Lung Cancer: Focus on the Clinical Development of Dacomitinib.
    Front Med (Lausanne) 2017 5;4:36. Epub 2017 Apr 5.
    Medical Oncology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación i+12, Madrid, Spain.
    Dacomitinib is a second-generation, irreversible, covalent pan-HER tyrosine-kinase inhibitor (TKI). It showed potent EGFR signaling inhibition in experimental models, including first-generation TKI-resistant non-small cell lung cancer (NSCLC) cell lines. This preclinical efficacy did not translate into clinically meaningful treatment benefits for advanced, pretreated, molecularly unselected NSCLC patients enrolled in two parallel phase III trials. Read More

    Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities.
    J Formos Med Assoc 2017 Jun 27;116(6):413-423. Epub 2017 Mar 27.
    Department of Dermatology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
    Background/purpose: This report describes the 2016 consensus of the Taiwanese Dermatological Association (TDA) regarding the definition, classification, diagnosis, prevention, and management of skin toxicities resulting from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). This consensus is distributed to practices throughout Taiwan to provide recommendations for the diagnosis and treatment of such skin toxicities in order to improve the quality of life of patients undergoing EGFR-TKI treatment. The consensus thus serves as an important reference for dermatologists and other interested clinicians, such as oncologists, throughout Taiwan. Read More

    EGFR inhibitory monoclonal antibodies and EGFR tyrosine kinase inhibitors have distinct effects on the keratinocyte innate immune response.
    Br J Dermatol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Dermatology, Nara Medical University, Nara, Japan.
    Epidermal growth factor receptor inhibitors (EGFRIs) are a well-established targeted therapy for several cancers. Two categories of EGFRIs are known, EGFR tyrosine kinase inhibitors (EGFR-TKIs) and EGFR monoclonal antibodies (EGFR mAbs). These EGFRIs frequently cause cutaneous adverse effects, such as papulo-pustular eruptions, xerosis and chronic paronychia. Read More

    Development of Photoonycholysis with Vandetanib Therapy.
    Skin Appendage Disord 2017 Jan 3;2(3-4):146-151. Epub 2016 Nov 3.
    Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France; Department of Medical Oncology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
    Vandetanib therapy is a novel once-daily oral multitargeted tyrosine kinase inhibitor, which is currently used in advanced or metastatic medullary thyroid cancer. Skin toxicities are among the most prevalent adverse events reported with this targeted therapy (e.g. Read More

    Dermatux: phase IV trial of Cetuximab plus FOLFIRI in first-line metastatic colorectal cancer receiving a pre-defined skin care.
    J Cancer Res Clin Oncol 2017 Jun 14;143(6):1023-1034. Epub 2017 Feb 14.
    1. Med. Klinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
    Purpose: Cetuximab-induced skin rash Gd3+ occurs in ≥16% patients (pts) (Heinemann et al., Lancet Oncol 15(10):1065-1075, 2014; Van Cutsem et al. J Clin Oncol 27(19):3117-25; 2009b). Read More

    Dermatologic Reactions to Targeted Therapy: A Focus on Epidermal Growth Factor Receptor Inhibitors and Nursing Care.
    Nurs Clin North Am 2017 Mar;52(1):83-113
    Department of Nursing Research, Memorial Sloan Kettering Cancer Center, 205 East 64th Street, Room 251 Concourse Level, New York, NY 10065, USA.
    Cancer treatments usually have side effects of bone marrow depression, mucositis, hair loss, and gastrointestinal issues. Rarely do we think of skin side effects until patients have been treated successfully with epidermal growth factor receptor inhibitors (EGFRi). Those reactions include papulopustular rash, hair changes, radiation dermatitis enhancement, pruritus, mucositis, xerosis, fissures, and paronychia. Read More

    De novo thrombotic microangiopathy following simultaneous pancreas and kidney transplantation managed with eculizumab.
    Nephrology (Carlton) 2017 Feb;22 Suppl 1:23-27
    Department of Nephrology, Monash Health, Melbourne, Victoria, Australia.
    Thrombotic microangiopathy (TMA) is a well-recognised complication following transplantation, often due to an underlying genetic predisposition, medications or rejection. The use of eculizumab in these settings has been previously described, but its role still remains to be clarified. A 45-year-old man, with a history of type 1 diabetes mellitus and subsequent end-stage kidney failure, presented for a simultaneous pancreas-kidney transplant. Read More

    MDCT of hand and wrist infections: emphasis on compartmental anatomy.
    Clin Radiol 2017 Apr 6;72(4):338.e1-338.e9. Epub 2017 Jan 6.
    The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, 601 North Wolfe Street, Baltimore, MD 21287, USA.
    Hand and wrist infections can present with a spectrum of manifestations ranging from cellulitis to deep-space collections. The various infectious processes can be categorised as superficial or deep infections based on their respective locations relative to the tendons. Superficial hand infections are located superficial to the tendons and are comprised of cellulitis, lymphangitis, paronychia, pulp-space infections, herpetic whitlow, and include volar as well as dorsal subcutaneous abscesses. Read More

    Cutaneous Side Effects and Transepidermal Water Loss To Gefitinib: A Study of 11 Patients.
    Dermatol Ther (Heidelb) 2017 Mar 21;7(1):133-141. Epub 2016 Dec 21.
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Introduction: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor.

    Methods: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016. Read More

    Cutaneous Reactions in Children Treated with the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase Inhibitor Trametinib for Neural Tumors.
    Pediatr Dermatol 2017 Jan 16;34(1):90-94. Epub 2016 Dec 16.
    Division of Pediatric Dermatology, Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.
    Background: The mitogen-activated protein kinase (MAPK) pathway is a target for the treatment of a growing number of malignancies. The cutaneous reactions to medications that inhibit this pathway have not been described in children.

    Methods: A retrospective chart review was completed for eight children with neural tumors treated with the MAPK extracellular signal-regulated kinase inhibitor trametinib. Read More

    Clindamycin-induced acute generalised exanthematous pustulosis: five cases and a review of the literature.
    Neth J Med 2016 Dec;74(10):421-428
    1Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the Netherlands.
    Acute generalised exanthematous pustulosis (AGEP) is a rare but serious cutaneous adverse drug reaction, often related to antibiotics such as beta-lactams or macrolides. However, it is rarely associated with clindamycin which belongs to the lincosamide antibiotics. The Netherlands Pharmacovigilance Centre Lareb received five reports of AGEP associated with the use of clindamycin. Read More

    LJM716 in Japanese patients with head and neck squamous cell carcinoma or HER2-overexpressing breast or gastric cancer.
    Cancer Chemother Pharmacol 2017 Jan 9;79(1):131-138. Epub 2016 Dec 9.
    Department of Gastrointestinal and Medical Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
    Purpose: Human epidermal growth factor receptor 3 (HER3) has been identified as an important component of many receptor tyrosine kinase-driven cancers. LJM716 is a human IgG monoclonal antibody that binds HER3, trapping it in an inactive conformation. In this study, a phase I dose escalation was performed with a primary objective to establish the maximum tolerated dose and/or the recommended dose of LJM716 in Japanese patients with selected advanced solid tumors. Read More

    A phase 1 study combining the HER3 antibody seribantumab (MM-121) and cetuximab with and without irinotecan.
    Invest New Drugs 2017 Feb 16;35(1):68-78. Epub 2016 Nov 16.
    University of California - San Francisco, Box 1705, UCSF, San Francisco, CA, 94143-1705, USA.
    Background HER3/EGFR heterodimers have been implicated as a mode of resistance to EGFR-directed therapies. Methods This Phase 1 trial assessed the tolerability, maximum tolerated dose (MTD) and pharmacokinetic (PK) properties of the HER-3 antibody seribantumab in combination with cetuximab (Part I) or cetuximab and irinotecan (Part II) in patients with EGFR-dependent cancers. In Part I, escalating doses of seribantumab and cetuximab were administered. Read More

    Allergic contact dermatitis from acrylic nails in a flamenco guitarist.
    Occup Med (Lond) 2016 Dec 7;66(9):751-753. Epub 2016 Nov 7.
    Dermatology Department, University Hospital of Guadalajara, Guadalajara 19002, Spain.
    Acrylates are molecules that are well known for their strong sensitizing properties. Historically, many beauticians and individuals using store-bought artificial nail products have developed allergic contact dermatitis from acrylates. More recently, the use of acrylic nails among flamenco guitarists to strengthen their nails has become very popular. Read More

    Factors influencing cure rates of non-dermatophyte mold and Candida onychomycosis: analysis of outcomes in 81 patients who completed treatment.
    Int J Dermatol 2017 Feb 4;56(2):202-208. Epub 2016 Nov 4.
    Department of Evaluation and Research, National Institute of Health Sciences, Kalutara, Sri Lanka.
    Objectives: Onychomycosis shows a poor response to current topical, oral, or device-related antifungal therapies. The aim of this study was to identify factors influencing the cure rates of non-dermatophyte mold and Candida onychomycosis.

    Methods: Eighty-one patients who completed treatments were divided into "cured" and "non-cured" groups. Read More

    Discovering Outliers of Potential Drug Toxicities Using a Large-scale Data-driven Approach.
    Cancer Inform 2016 26;15:211-217. Epub 2016 Oct 26.
    Center for Biomedical Data and Language Processing, Department of Health Informatics and Administration, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; Department of Health Informatics and Administration, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; Center for Urban Population Health, Milwaukee, WI, USA.; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
    We systematically compared the adverse effects of cancer drugs to detect event outliers across different clinical trials using a data-driven approach. Because many cancer drugs are toxic to patients, better understanding of adverse events of cancer drugs is critical for developing therapies that could minimize the toxic effects. However, due to the large variabilities of adverse events across different cancer drugs, methods to efficiently compare adverse effects across different cancer drugs are lacking. Read More

    Nail changes in casted and braced clubfoot: A preliminary study.
    Foot Ankle Surg 2016 Dec 27;22(4):229-232. Epub 2015 Oct 27.
    Department of Paediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India. Electronic address:
    Background: The study aimed at finding whether there are any nail changes specific to treatment in clubfoot.

    Methods: Sixty new, 26 undergoing serial corrective casting, and 247 clubfoot patients using foot abduction braces were prospectively studied. The casted and braced group formed the basis of the study to observe nail changes, if any. Read More

    Toenail paronychia.
    Foot Ankle Surg 2016 Dec 21;22(4):219-223. Epub 2015 Sep 21.
    Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, United Kingdom.
    Paronychia is an inflammation of the tissues alongside the nail. It may be acute or chronic and can be seen in isolation or in association with an ingrowing toenail. Acute paronychial infections develop when a disruption occurs between the seal of the nail fold and the nail plate, providing a portal of entry for invading organisms. Read More

    MRSA infections among patients in the emergency department: a European multicentre study.
    J Antimicrob Chemother 2017 Feb 17;72(2):372-375. Epub 2016 Oct 17.
    National Reference Center for Staphylococci, 59 Bd Louis Pinel, 69677 Bron cedex, Lyon, France.
    Background: MRSA is a therapeutic concern worldwide, and a major agent of community-acquired skin and soft tissue infections (CA-SSTIs). While the US epidemiology of MRSA in CA-SSTIs is well described and reports the high prevalence of the USA300 clone, data on the European situation are lacking.

    Objectives: To determine the prevalence and clonal characteristics of MRSA in CA-SSTIs in seven European emergency departments. Read More

    Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient.
    J Dermatol 2017 Jan 8;44(1):88-90. Epub 2016 Sep 8.
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
    The patient was a 73-year-old healthy female farmer who had been treated with terbinafine for 25.5 months by a primary physician. She exhibited a discoloration and thickening of the right big toenail. Read More

    Dermatoses among Children from Celebration of "Holi," the Spring Festival, in India: A Cross-sectional Observational Study.
    Indian J Dermatol 2016 Sep-Oct;61(5):525-8
    Department of Dermatology, Venereology, and Leprosy, R.G. Kar Medical College, Kolkata, West Bengal, India.
    Background: "Holi" is a spring festival celebrated primarily in the Indian subcontinent and also abroad by expatriate Indians. It is a festival of colors, traditionally celebrated by mutual application of colors in different forms on a particular day of the year. These colors frequently comprise a range of synthetic dyes which have harmful effects on the skin and mucosae. Read More

    Drug-Induced Itch Management.
    Curr Probl Dermatol 2016 23;50:155-63. Epub 2016 Aug 23.
    Department of Dermatology, The Jikei University School of Medicine, Chitofuna Dermatology Clinic, Tokyo, Japan.
    Drugs may cause itching as a concomitant symptom of drug-induced skin reactions or in the form of pruritus without skin lesions. Drug-induced itch is defined as generalized itching without skin lesions, caused by a drug. Itching associated with drug-induced cholestasis is among the common dermatologic adverse events (dAEs) that induce itching. Read More

    Nail psoriasis in an adult successfully treated with a series of herbal skin care products family – a case report.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):21-8
    Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.
    Psoriasis is a common chronic inflammatory dermatosis that causes significant distress and morbidity. Approximately 50% of patients with cutaneous psoriasis and 90% of patients with psoriatic arthritis demonstrate nail involvement of their psoriasis. Left untreated, nail psoriasis may progress to debilitating nail disease that leads to not only impairment of function but also on quality of life. Read More

    Multicenter phase II study of combination therapy with cetuximab and S-1 in patients with KRAS exon 2 wild-type unresectable colorectal cancer previously treated with irinotecan, oxaliplatin, and fluoropyrimidines (KSCC 0901 study).
    Cancer Chemother Pharmacol 2016 Sep 28;78(3):585-93. Epub 2016 Jul 28.
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Purpose: Anti-epidermal growth factor receptor antibody therapy alone or in combination with irinotecan is recognized as a standard third-line treatment for KRAS wild-type unresectable metastatic colorectal cancer. However, in some cases, it is difficult to administer irinotecan after third-line treatment. Therefore, we examined the efficacy and safety of the combination of cetuximab and S-1 in patients with KRAS wild-type unresectable metastatic colorectal cancer who were previously treated with irinotecan, oxaliplatin, and fluoropyrimidines. Read More

    A Randomized Phase 2 Study Comparing the Combination of Ficlatuzumab and Gefitinib with Gefitinib Alone in Asian Patients with Advanced Stage Pulmonary Adenocarcinoma.
    J Thorac Oncol 2016 Oct 21;11(10):1736-44. Epub 2016 Jul 21.
    Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Introduction: A randomized phase 2 study was designed to compare the combination of ficlatuzumab (AV-299), a humanized hepatocyte growth factor-neutralizing monoclonal antibody, plus gefitinib versus gefitinib monotherapy in a pulmonary adenocarcinoma population clinically enriched for EFGR tyrosine kinase inhibitor-sensitizing mutations.

    Methods: A total of 188 patients were randomized 1:1 to receive either gefitinib or ficlatuzumab plus gefitinib treatment. Patients who demonstrated disease control in the single-agent gefitinib arm were allowed to cross over to ficlatuzumab plus gefitinib treatment upon disease progression. Read More

    Initial misdiagnosis of melanoma located on the foot is associated with poorer prognosis.
    Medicine (Baltimore) 2016 Jul;95(29):e4332
    Department of Dermatology, Venerology and Allergology, University School of Medicine Essen-Duisburg, Essen, Germany.
    Acral melanoma has been reported to be associated with poorer outcomes than melanoma occurring on other cutaneous sites. It has been suggested that part of this disparity in outcomes may be related to delay in diagnosis. Therefore, we have analyzed the rate of misdiagnoses in patients with melanoma located on the foot and have characterized the influence on the clinical course and survival of the patients. Read More

    [Toxicity associated with EGRF inhibition: review and key aspects in the management of afatinib].
    Med Clin (Barc) 2016 Apr;146 Suppl 1:30-5
    Servicio de Oncología Médica, Hospital del Mar, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Barcelona, España. Electronic address:
    Afatinib is an irreversible tyrosine kinase inhibitor of the ErbB family, approved for the treatment of patients with non-small cell lung cancer with EGFR-sensitizing mutations. Like other EGFR inhibitors, afatinib can provoke adverse events such as diarrhoea, rash, paronychia or mucositis. The correct management of these adverse events is essential to maintain quality of life in these patients and obtain the maximum benefit from afatinib therapy. Read More

    Congenital Malalignment of the Great Toenails With Acute Paronychia.
    Pediatr Dermatol 2016 Sep 11;33(5):e288-9. Epub 2016 Jul 11.
    Department of Dermatology, Weill Cornell Medicine, New York, New York.
    Congenital malalignment of the great toenails (CMGT) has been well documented. In the present case, it was complicated by acute paronychia. It is important for physicians to recognize and treat CMGT to prevent sequelae such as onychocryptosis, onychogryphosis, and recurrent paronychia. Read More

    Evaluation of cytology collection techniques and prevalence of Malassezia yeast and bacteria in claw folds of normal and allergic dogs.
    Vet Dermatol 2016 Aug;27(4):279-e67
    Animal Dermatology Clinic, 2965 Edinger Avenue, Tustin, CA, 92780, USA.
    Background: Canine bacterial and Malassezia paronychia are common secondary complications of atopic dermatitis and adverse food reactions.

    Hypothesis/objectives: The aim of this study was to compare three different sampling methods for claw fold cytology and to evaluate the numbers of bacteria, Malassezia yeast and inflammatory cells.

    Animals: Sixty client-owned dogs were classified into three groups: (A) normal dogs; (B) allergic dogs with no clinical evidence of claw disease (brown staining, erythema, swelling, crusts or exudates); and (C) allergic dogs with clinical paronychia. Read More

    Oral Antifungal Drugs in the Treatment of Dermatomycosis.
    Med Mycol J 2016 ;57(2):J71-5
    Department of Dermatology, Tokyo Women's Medical University.
    Oral antifungal drugs are used primarily to treat tinea unguium; however, they are also useful for other types of tinea. For example, a combination of topical and oral antifungal drugs is effective in hyperkeratotic tinea pedis that is unresponsive to topical monotherapy. In cases of tinea facialis adjacent to the eyes, ears, or mouth, or widespread tinea corporis, or tinea cruris involving the complex skin folds of the external genitalia, it is difficult to apply topical drugs to all the lesions; therefore, oral antifungal drugs are necessary. Read More

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