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    Second-line Treatment of Non-Small Cell Lung Cancer: Focus on the Clinical Development of Dacomitinib.
    Front Med (Lausanne) 2017 5;4:36. Epub 2017 Apr 5.
    Medical Oncology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación i+12, Madrid, Spain.
    Dacomitinib is a second-generation, irreversible, covalent pan-HER tyrosine-kinase inhibitor (TKI). It showed potent EGFR signaling inhibition in experimental models, including first-generation TKI-resistant non-small cell lung cancer (NSCLC) cell lines. This preclinical efficacy did not translate into clinically meaningful treatment benefits for advanced, pretreated, molecularly unselected NSCLC patients enrolled in two parallel phase III trials. Read More

    Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities.
    J Formos Med Assoc 2017 Mar 27. Epub 2017 Mar 27.
    Department of Dermatology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
    Background/purpose: This report describes the 2016 consensus of the Taiwanese Dermatological Association (TDA) regarding the definition, classification, diagnosis, prevention, and management of skin toxicities resulting from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). This consensus is distributed to practices throughout Taiwan to provide recommendations for the diagnosis and treatment of such skin toxicities in order to improve the quality of life of patients undergoing EGFR-TKI treatment. The consensus thus serves as an important reference for dermatologists and other interested clinicians, such as oncologists, throughout Taiwan. Read More

    EGFR inhibitory monoclonal antibodies and EGFR tyrosine kinase inhibitors have distinct effects on the keratinocyte innate immune response.
    Br J Dermatol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Dermatology, Nara Medical University, Nara, Japan.
    Epidermal growth factor receptor inhibitors (EGFRIs) are a well-established targeted therapy for several cancers. Two categories of EGFRIs are known, EGFR tyrosine kinase inhibitors (EGFR-TKIs) and EGFR monoclonal antibodies (EGFR mAbs). These EGFRIs frequently cause cutaneous adverse effects, such as papulo-pustular eruptions, xerosis and chronic paronychia. Read More

    Development of Photoonycholysis with Vandetanib Therapy.
    Skin Appendage Disord 2017 Jan 3;2(3-4):146-151. Epub 2016 Nov 3.
    Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France; Department of Medical Oncology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
    Vandetanib therapy is a novel once-daily oral multitargeted tyrosine kinase inhibitor, which is currently used in advanced or metastatic medullary thyroid cancer. Skin toxicities are among the most prevalent adverse events reported with this targeted therapy (e.g. Read More

    Dermatux: phase IV trial of Cetuximab plus FOLFIRI in first-line metastatic colorectal cancer receiving a pre-defined skin care.
    J Cancer Res Clin Oncol 2017 Feb 14. Epub 2017 Feb 14.
    1. Med. Klinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
    Purpose: Cetuximab-induced skin rash Gd3+ occurs in ≥16% patients (pts) (Heinemann et al., Lancet Oncol 15(10):1065-1075, 2014; Van Cutsem et al. J Clin Oncol 27(19):3117-25; 2009b). Read More

    Dermatologic Reactions to Targeted Therapy: A Focus on Epidermal Growth Factor Receptor Inhibitors and Nursing Care.
    Nurs Clin North Am 2017 Mar;52(1):83-113
    Department of Nursing Research, Memorial Sloan Kettering Cancer Center, 205 East 64th Street, Room 251 Concourse Level, New York, NY 10065, USA.
    Cancer treatments usually have side effects of bone marrow depression, mucositis, hair loss, and gastrointestinal issues. Rarely do we think of skin side effects until patients have been treated successfully with epidermal growth factor receptor inhibitors (EGFRi). Those reactions include papulopustular rash, hair changes, radiation dermatitis enhancement, pruritus, mucositis, xerosis, fissures, and paronychia. Read More

    De novo thrombotic microangiopathy following simultaneous pancreas and kidney transplantation managed with eculizumab.
    Nephrology (Carlton) 2017 Feb;22 Suppl 1:23-27
    Department of Nephrology, Monash Health, Melbourne, Victoria, Australia.
    Thrombotic microangiopathy (TMA) is a well-recognised complication following transplantation, often due to an underlying genetic predisposition, medications or rejection. The use of eculizumab in these settings has been previously described, but its role still remains to be clarified. A 45-year-old man, with a history of type 1 diabetes mellitus and subsequent end-stage kidney failure, presented for a simultaneous pancreas-kidney transplant. Read More

    MDCT of hand and wrist infections: emphasis on compartmental anatomy.
    Clin Radiol 2017 Apr 6;72(4):338.e1-338.e9. Epub 2017 Jan 6.
    The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, 601 North Wolfe Street, Baltimore, MD 21287, USA.
    Hand and wrist infections can present with a spectrum of manifestations ranging from cellulitis to deep-space collections. The various infectious processes can be categorised as superficial or deep infections based on their respective locations relative to the tendons. Superficial hand infections are located superficial to the tendons and are comprised of cellulitis, lymphangitis, paronychia, pulp-space infections, herpetic whitlow, and include volar as well as dorsal subcutaneous abscesses. Read More

    Cutaneous Side Effects and Transepidermal Water Loss To Gefitinib: A Study of 11 Patients.
    Dermatol Ther (Heidelb) 2017 Mar 21;7(1):133-141. Epub 2016 Dec 21.
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Introduction: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor.

    Methods: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016. Read More

    Cutaneous Reactions in Children Treated with the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase Inhibitor Trametinib for Neural Tumors.
    Pediatr Dermatol 2017 Jan 16;34(1):90-94. Epub 2016 Dec 16.
    Division of Pediatric Dermatology, Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.
    Background: The mitogen-activated protein kinase (MAPK) pathway is a target for the treatment of a growing number of malignancies. The cutaneous reactions to medications that inhibit this pathway have not been described in children.

    Methods: A retrospective chart review was completed for eight children with neural tumors treated with the MAPK extracellular signal-regulated kinase inhibitor trametinib. Read More

    LJM716 in Japanese patients with head and neck squamous cell carcinoma or HER2-overexpressing breast or gastric cancer.
    Cancer Chemother Pharmacol 2017 Jan 9;79(1):131-138. Epub 2016 Dec 9.
    Department of Gastrointestinal and Medical Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
    Purpose: Human epidermal growth factor receptor 3 (HER3) has been identified as an important component of many receptor tyrosine kinase-driven cancers. LJM716 is a human IgG monoclonal antibody that binds HER3, trapping it in an inactive conformation. In this study, a phase I dose escalation was performed with a primary objective to establish the maximum tolerated dose and/or the recommended dose of LJM716 in Japanese patients with selected advanced solid tumors. Read More

    A phase 1 study combining the HER3 antibody seribantumab (MM-121) and cetuximab with and without irinotecan.
    Invest New Drugs 2017 Feb 16;35(1):68-78. Epub 2016 Nov 16.
    University of California - San Francisco, Box 1705, UCSF, San Francisco, CA, 94143-1705, USA.
    Background HER3/EGFR heterodimers have been implicated as a mode of resistance to EGFR-directed therapies. Methods This Phase 1 trial assessed the tolerability, maximum tolerated dose (MTD) and pharmacokinetic (PK) properties of the HER-3 antibody seribantumab in combination with cetuximab (Part I) or cetuximab and irinotecan (Part II) in patients with EGFR-dependent cancers. In Part I, escalating doses of seribantumab and cetuximab were administered. Read More

    Allergic contact dermatitis from acrylic nails in a flamenco guitarist.
    Occup Med (Lond) 2016 Dec 7;66(9):751-753. Epub 2016 Nov 7.
    Dermatology Department, University Hospital of Guadalajara, Guadalajara 19002, Spain.
    Acrylates are molecules that are well known for their strong sensitizing properties. Historically, many beauticians and individuals using store-bought artificial nail products have developed allergic contact dermatitis from acrylates. More recently, the use of acrylic nails among flamenco guitarists to strengthen their nails has become very popular. Read More

    Factors influencing cure rates of non-dermatophyte mold and Candida onychomycosis: analysis of outcomes in 81 patients who completed treatment.
    Int J Dermatol 2017 Feb 4;56(2):202-208. Epub 2016 Nov 4.
    Department of Evaluation and Research, National Institute of Health Sciences, Kalutara, Sri Lanka.
    Objectives: Onychomycosis shows a poor response to current topical, oral, or device-related antifungal therapies. The aim of this study was to identify factors influencing the cure rates of non-dermatophyte mold and Candida onychomycosis.

    Methods: Eighty-one patients who completed treatments were divided into "cured" and "non-cured" groups. Read More

    Discovering Outliers of Potential Drug Toxicities Using a Large-scale Data-driven Approach.
    Cancer Inform 2016 26;15:211-217. Epub 2016 Oct 26.
    Center for Biomedical Data and Language Processing, Department of Health Informatics and Administration, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; Department of Health Informatics and Administration, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; Center for Urban Population Health, Milwaukee, WI, USA.; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
    We systematically compared the adverse effects of cancer drugs to detect event outliers across different clinical trials using a data-driven approach. Because many cancer drugs are toxic to patients, better understanding of adverse events of cancer drugs is critical for developing therapies that could minimize the toxic effects. However, due to the large variabilities of adverse events across different cancer drugs, methods to efficiently compare adverse effects across different cancer drugs are lacking. Read More

    Nail changes in casted and braced clubfoot: A preliminary study.
    Foot Ankle Surg 2016 Dec 27;22(4):229-232. Epub 2015 Oct 27.
    Department of Paediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India. Electronic address:
    Background: The study aimed at finding whether there are any nail changes specific to treatment in clubfoot.

    Methods: Sixty new, 26 undergoing serial corrective casting, and 247 clubfoot patients using foot abduction braces were prospectively studied. The casted and braced group formed the basis of the study to observe nail changes, if any. Read More

    Toenail paronychia.
    Foot Ankle Surg 2016 Dec 21;22(4):219-223. Epub 2015 Sep 21.
    Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, United Kingdom.
    Paronychia is an inflammation of the tissues alongside the nail. It may be acute or chronic and can be seen in isolation or in association with an ingrowing toenail. Acute paronychial infections develop when a disruption occurs between the seal of the nail fold and the nail plate, providing a portal of entry for invading organisms. Read More

    MRSA infections among patients in the emergency department: a European multicentre study.
    J Antimicrob Chemother 2017 Feb 17;72(2):372-375. Epub 2016 Oct 17.
    National Reference Center for Staphylococci, 59 Bd Louis Pinel, 69677 Bron cedex, Lyon, France.
    Background: MRSA is a therapeutic concern worldwide, and a major agent of community-acquired skin and soft tissue infections (CA-SSTIs). While the US epidemiology of MRSA in CA-SSTIs is well described and reports the high prevalence of the USA300 clone, data on the European situation are lacking.

    Objectives: To determine the prevalence and clonal characteristics of MRSA in CA-SSTIs in seven European emergency departments. Read More

    Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient.
    J Dermatol 2017 Jan 8;44(1):88-90. Epub 2016 Sep 8.
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
    The patient was a 73-year-old healthy female farmer who had been treated with terbinafine for 25.5 months by a primary physician. She exhibited a discoloration and thickening of the right big toenail. Read More

    Dermatoses among Children from Celebration of "Holi," the Spring Festival, in India: A Cross-sectional Observational Study.
    Indian J Dermatol 2016 Sep-Oct;61(5):525-8
    Department of Dermatology, Venereology, and Leprosy, R.G. Kar Medical College, Kolkata, West Bengal, India.
    Background: "Holi" is a spring festival celebrated primarily in the Indian subcontinent and also abroad by expatriate Indians. It is a festival of colors, traditionally celebrated by mutual application of colors in different forms on a particular day of the year. These colors frequently comprise a range of synthetic dyes which have harmful effects on the skin and mucosae. Read More

    Drug-Induced Itch Management.
    Curr Probl Dermatol 2016 23;50:155-63. Epub 2016 Aug 23.
    Department of Dermatology, The Jikei University School of Medicine, Chitofuna Dermatology Clinic, Tokyo, Japan.
    Drugs may cause itching as a concomitant symptom of drug-induced skin reactions or in the form of pruritus without skin lesions. Drug-induced itch is defined as generalized itching without skin lesions, caused by a drug. Itching associated with drug-induced cholestasis is among the common dermatologic adverse events (dAEs) that induce itching. Read More

    Nail psoriasis in an adult successfully treated with a series of herbal skin care products family – a case report.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):21-8
    Chair of Dermatology, University of Rome “G. Marconi” Rome, Italy.
    Psoriasis is a common chronic inflammatory dermatosis that causes significant distress and morbidity. Approximately 50% of patients with cutaneous psoriasis and 90% of patients with psoriatic arthritis demonstrate nail involvement of their psoriasis. Left untreated, nail psoriasis may progress to debilitating nail disease that leads to not only impairment of function but also on quality of life. Read More

    Multicenter phase II study of combination therapy with cetuximab and S-1 in patients with KRAS exon 2 wild-type unresectable colorectal cancer previously treated with irinotecan, oxaliplatin, and fluoropyrimidines (KSCC 0901 study).
    Cancer Chemother Pharmacol 2016 Sep 28;78(3):585-93. Epub 2016 Jul 28.
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Purpose: Anti-epidermal growth factor receptor antibody therapy alone or in combination with irinotecan is recognized as a standard third-line treatment for KRAS wild-type unresectable metastatic colorectal cancer. However, in some cases, it is difficult to administer irinotecan after third-line treatment. Therefore, we examined the efficacy and safety of the combination of cetuximab and S-1 in patients with KRAS wild-type unresectable metastatic colorectal cancer who were previously treated with irinotecan, oxaliplatin, and fluoropyrimidines. Read More

    A Randomized Phase 2 Study Comparing the Combination of Ficlatuzumab and Gefitinib with Gefitinib Alone in Asian Patients with Advanced Stage Pulmonary Adenocarcinoma.
    J Thorac Oncol 2016 Oct 21;11(10):1736-44. Epub 2016 Jul 21.
    Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Introduction: A randomized phase 2 study was designed to compare the combination of ficlatuzumab (AV-299), a humanized hepatocyte growth factor-neutralizing monoclonal antibody, plus gefitinib versus gefitinib monotherapy in a pulmonary adenocarcinoma population clinically enriched for EFGR tyrosine kinase inhibitor-sensitizing mutations.

    Methods: A total of 188 patients were randomized 1:1 to receive either gefitinib or ficlatuzumab plus gefitinib treatment. Patients who demonstrated disease control in the single-agent gefitinib arm were allowed to cross over to ficlatuzumab plus gefitinib treatment upon disease progression. Read More

    Initial misdiagnosis of melanoma located on the foot is associated with poorer prognosis.
    Medicine (Baltimore) 2016 Jul;95(29):e4332
    Department of Dermatology, Venerology and Allergology, University School of Medicine Essen-Duisburg, Essen, Germany.
    Acral melanoma has been reported to be associated with poorer outcomes than melanoma occurring on other cutaneous sites. It has been suggested that part of this disparity in outcomes may be related to delay in diagnosis. Therefore, we have analyzed the rate of misdiagnoses in patients with melanoma located on the foot and have characterized the influence on the clinical course and survival of the patients. Read More

    [Toxicity associated with EGRF inhibition: review and key aspects in the management of afatinib].
    Med Clin (Barc) 2016 Apr;146 Suppl 1:30-5
    Servicio de Oncología Médica, Hospital del Mar, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Barcelona, España. Electronic address:
    Afatinib is an irreversible tyrosine kinase inhibitor of the ErbB family, approved for the treatment of patients with non-small cell lung cancer with EGFR-sensitizing mutations. Like other EGFR inhibitors, afatinib can provoke adverse events such as diarrhoea, rash, paronychia or mucositis. The correct management of these adverse events is essential to maintain quality of life in these patients and obtain the maximum benefit from afatinib therapy. Read More

    Congenital Malalignment of the Great Toenails With Acute Paronychia.
    Pediatr Dermatol 2016 Sep 11;33(5):e288-9. Epub 2016 Jul 11.
    Department of Dermatology, Weill Cornell Medicine, New York, New York.
    Congenital malalignment of the great toenails (CMGT) has been well documented. In the present case, it was complicated by acute paronychia. It is important for physicians to recognize and treat CMGT to prevent sequelae such as onychocryptosis, onychogryphosis, and recurrent paronychia. Read More

    Evaluation of cytology collection techniques and prevalence of Malassezia yeast and bacteria in claw folds of normal and allergic dogs.
    Vet Dermatol 2016 Aug;27(4):279-e67
    Animal Dermatology Clinic, 2965 Edinger Avenue, Tustin, CA, 92780, USA.
    Background: Canine bacterial and Malassezia paronychia are common secondary complications of atopic dermatitis and adverse food reactions.

    Hypothesis/objectives: The aim of this study was to compare three different sampling methods for claw fold cytology and to evaluate the numbers of bacteria, Malassezia yeast and inflammatory cells.

    Animals: Sixty client-owned dogs were classified into three groups: (A) normal dogs; (B) allergic dogs with no clinical evidence of claw disease (brown staining, erythema, swelling, crusts or exudates); and (C) allergic dogs with clinical paronychia. Read More

    Oral Antifungal Drugs in the Treatment of Dermatomycosis.
    Med Mycol J 2016 ;57(2):J71-5
    Department of Dermatology, Tokyo Women's Medical University.
    Oral antifungal drugs are used primarily to treat tinea unguium; however, they are also useful for other types of tinea. For example, a combination of topical and oral antifungal drugs is effective in hyperkeratotic tinea pedis that is unresponsive to topical monotherapy. In cases of tinea facialis adjacent to the eyes, ears, or mouth, or widespread tinea corporis, or tinea cruris involving the complex skin folds of the external genitalia, it is difficult to apply topical drugs to all the lesions; therefore, oral antifungal drugs are necessary. Read More

    A Case of Fingernail Onychomycosis due to Aspergillus flavus.
    Med Mycol J 2016 ;57(2):E21-5
    Noguchi Dermatology Clinic.
    A 56-year-old woman on insulin therapy for diabetes visited our clinic due to whitish discoloration on the right index finger. Despite topical application of 1% lanoconazole solution, the lesion grew, causing paronychia. Direct microscopy revealed non-dermatophyte molds. Read More

    Paronychia and granulation tissue formation during treatment with isotretinoin.
    An Bras Dermatol 2016 Apr;91(2):223-5
    Instituto Materno Infantil Professor Fernando Figueira, Recife, PE, Brazil.
    This paper describes the association of two unusual side effects of treatment with isotretinoin for severe acne: paronychia and excess granulation tissue in the nails furrows. We report a case of male patient aged 19 years, who in the course of the 36th week of treatment with isotretinoin for acne grade III showed erythema, edema, excess granulation tissue and onychocryptosis in various nail beds of hands and feet, with no history of trauma associated. A literature review revealed few reports of these adverse events, and two clinical patterns of exuberant granulation tissue has been described: one in periungual location and other in lesions of previous acne. Read More

    Acquired Congenital Malalignment of the Great Toenails.
    Skin Appendage Disord 2016 Feb 28;1(3):147-9. Epub 2015 Nov 28.
    Department of Dermatology, Weill Cornell/New York Presbyterian, New York, N.Y., USA.
    Congenital malalignment is the lateral deviation of the nail plate along the longitudinal axis due to the lateral rotation of the nail matrix. The nail plate grows out in ridges caused by repeated microtrauma to the nail. Common complications include onychomycosis, Pseudomonas infection and acute or chronic paronychia. Read More

    Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.
    Acta Dermatovenerol Croat 2016 Apr;24(1):70-2
    Daška Štulhofer Buzina, MD, PhD, University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;
    Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are the most common adverse reactions occurring during epidermal growth factor receptor inhibitors (EGFRI) therapy. Read More

    Initial Report of Phase II Study on Bi-weekly SOX plus Cetuximab Treatment for Wild-type K-RAS Advanced and Recurrent Colorectal Cancer.
    Anticancer Res 2016 May;36(5):2505-11
    Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
    Aim: This prospective study was designed to evaluate the tolerability and the efficacy of bi-weekly SOX (S-1 and oxaliplatin)+cetuximab as first-line chemotherapy for wild-type K-RAS metastatic colorectal cancer.

    Patients And Methods: We studied patients with previously untreated, unresectable, advanced or recurrent colorectal cancer who were treated in our hospital between October 2010 and March 2013. Their performance status (PS) was 0 to 1. Read More

    Risk factors, clinical variants and therapeutic outcome of retronychia: a retrospective study of 18 patients.
    Eur J Dermatol 2016 Aug;26(4):377-81
    Saint-André Hospital, University Hospital of Bordeaux, 1 rue Jean Burguet, 33000 Bordeaux, France.
    Retronychia is a form of post-traumatic ingrowing nail disease that involves proximal nail plate embedding into the proximal nail fold, with multiple generations of nail plate beneath the proximal nail. This disease is probably underdiagnosed because of incomplete clinical forms. The aim of this study was to report clinical and aetiological variants of retronychia and to evaluate their therapeutic outcome. Read More

    Acute felon and paronychia: Antibiotics not necessary after surgical treatment. Prospective study of 46 patients.
    Hand Surg Rehabil 2016 Feb 16;35(1):40-3. Epub 2016 Feb 16.
    Service de chirurgie de la main, du membre supérieur et des nerfs périphériques, hôpital européen Georges-Pompidou, université Paris-Descartes, Sorbonne Paris Cité, Assistance publique-Hôpitaux de Paris (AP-HP), 20, rue Leblanc, 75908 Paris cedex 15, France.
    Paronychia and felon are the most common infections of the hand. Surgical treatment is required once an abscess develops, but systematic use of postoperative antibiotic therapy remains open for discussion. Antibiotics both favor the selection of resistant bacteria and increase the cost of treatment. Read More

    Management of Skin Reactions During Cetuximab Treatment in Association With Chemotherapy or Radiotherapy: Update of the Italian Expert Recommendations.
    Am J Clin Oncol 2016 Aug;39(4):407-15
    *Medical Oncology Unit, Clinical Cancer Centre, IRCCS-Arcispedale S. Maria Nuova, Reggio Emilia †Medical Oncology Unit, Università Cattolica Sacro Cuore, Rome ‡Department of Medicine, Section of Dermatology, University of Verona, Verona §Radiotherapy Unit ∥Oncology Unit, Santa Croce and Carle Hospital, Cuneo ¶Oncology Unit, San Paolo Hospital, Milan #Oncology Unit, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy.
    Objectives: Cetuximab was shown in phase III clinical trials to improve chemotherapy efficacy in patients with advanced colorectal and head-neck cancer. Appropriate management of skin reactions associated with epidermal growth factor receptor inhibitor therapy is necessary to allow adequate drug compliance and to improve patient quality of life and outcomes.

    Methods: The RAND/UCLA Appropriateness Method was used by a group of experts to produce new Italian recommendations on the management of skin reactions in this setting. Read More

    Palmoplantar Keratoderma as a Variant of Lichen Planus.
    Skinmed 2016 1;14(1):56-60. Epub 2016 Feb 1.
    Department of Dermatology and STD, and the Department of Pathology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Shahdra, Delhi, India.
    A 52-year-old air conditioner mechanic presented with progressively itchy grayish white eruptions affecting the skin and mucous membranes, including his palms and soles for the past 2 months. The inner aspects of the palms and weight-bearing areas of the soles were the initial sites of presentation, resulting in a diffuse thickness of the palms and soles, which inhibited his everyday activity. The eruptions were asymptomatic but conspicuous. Read More

    Hair and nail adverse events during treatment with targeted therapies for metastatic melanoma.
    Eur J Dermatol 2016 Jun;26(3):232-9
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna.
    Targeted therapies for melanoma have shown clinical benefit in increasing the survival of metastatic patients. Cutaneous adverse events have been reported, but hair and nail data have been rarely detailed. Patients treated with BRAF and MEK inhibitors for metastatic melanoma underwent dermatological evaluation before the start of each treatment and after every four weeks. Read More

    Chronic paronychia treatment: Square flap technique.
    J Am Acad Dermatol 2016 Aug 4;75(2):398-403. Epub 2016 Mar 4.
    Dermatology Institute Prof. Rubem David Azulay, Nail Studies Center, Rio de Janeiro, Brazil.
    Background: Chronic paronychia is an inflammatory process of the periungual folds that lasts longer than 6 weeks. It manifests as hypertrophy of the proximal and lateral nailfolds, absence of cuticle, progressive retraction of the proximal nailfold, and onychodystrophy. Surgical treatment is recommended if there has been insufficient response to 6 months of appropriate medical therapies. Read More

    Retronychia: A Case Report Including Ultrasound Imaging and Surgical Treatment.
    Actas Dermosifiliogr 2016 Jun 27;107(5):e33-7. Epub 2016 Feb 27.
    Servicio de Dermatología, Hospital Universitario La Paz, Universidad Autónoma, Madrid, España.
    Retronychia is a recently described disorder caused by ingrowth of the proximal nail plate into the proximal nail fold. This situation provokes chronic paronychia refractory to antimicrobial therapy. Ultrasound has been proposed as the noninvasive method of choice to confirm the diagnosis and rule out other differential diagnoses, particularly local tumors and arthritic disease. Read More

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