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J Clin Oncol 2021 Aug 2:JCO2100662. Epub 2021 Aug 2.

Janssen R&D, Spring House, PA.

Purpose: Non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor () exon 20 insertion (Exon20ins) mutations exhibits inherent resistance to approved tyrosine kinase inhibitors. Amivantamab, an EGFR-MET bispecific antibody with immune cell-directing activity, binds to each receptor's extracellular domain, bypassing resistance at the tyrosine kinase inhibitor binding site.

Methods: CHRYSALIS is a phase I, open-label, dose-escalation, and dose-expansion study, which included a population with Exon20ins NSCLC. Read More

J Dermatolog Treat 2021 Aug 1:1-4. Epub 2021 Aug 1.

University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Although Americans seek care for their nail diseases on an outpatient basis, they also seek nail care in the setting of the emergency department (ED).

Purpose: This study aims to characterize the treatment of nail diseases at ED visits in the United States from 2009-2018.

Methods: Data from 2009-2018 was collected from the National Hospital Ambulatory Medical Care Survey for EDs. Read More

Indian J Dermatol Venereol Leprol 2021 Jul 7:1-5. Epub 2021 Jul 7.

Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Nail braces are reportedly effective for treating both acute inflamed and chronic dystrophic type ingrown toenails.

Aims: In this study, risk factors for poorly controlled and recurrence-prone ingrown toenails treated with nail braces were identified.

Methods: We performed a retrospective study on patients with ingrown toenails between June 1, 2015, and May 31, 2018. Read More

Int J Dermatol 2021 Jul 9. Epub 2021 Jul 9.

Department of Dermatology, Weill Cornell Medicine, New York City, New York, USA.

Chemotherapy-associated paronychia (CAP) is an inflammation of the nail folds in response to various chemotherapeutic medications. Altered proliferation of keratinocytes or nail matrix stem cells is thought to be a major causative factor. Prophylactic tetracyclines, topical povidone-iodine, and general irritation avoidance measures are among some of the recommended interventions for CAP. Read More

JAAD Case Rep 2021 Aug 4;14:1-3. Epub 2021 Jun 4.

Dermatology Department, University of Mississippi Medical Center, Jackson, Mississippi.

J Oncol 2021 16;2021:2414897. Epub 2021 Jun 16.

College of Medicine and Public Health, Flinders University, Flinders Drive, Bedford Park, Adelaide 5042, South Australia, Australia.

Introduction: Afatinib is a first-line treatment option for patients with an advanced nonsmall cell lung cancer (NSCLC) expressing an epidermal growth factor receptor (EGFR) activating mutation. This study aimed to evaluate the association between early adverse events induced by afatinib and overall survival (OS) and progression free survival (PFS) in patients with advanced NSCLC.

Methods: The study was a pooled post hoc analysis of the randomized trials LUX-Lung 3 and LUX-Lung 6 which evaluated afatinib versus pemetrexed-cisplatin or gemcitabine-cisplatin, respectively. Read More

Handchir Mikrochir Plast Chir 2021 Jun 16;53(3):259-266. Epub 2021 Jun 16.

Kantonsspital St. Gallen, Klinik für Plastische Chirurgie und Handchirurgie.

The infections of the terminal phalanx are always special. Diseases, tumors or virus infections can look very similar and can show similar symptoms. Many require a radiological, dermatological, histological or general physical clarification, some need no surgery and in some surgery is contraindicated. Read More

Handchir Mikrochir Plast Chir 2021 Jun 16;53(3):245-258. Epub 2021 Jun 16.

Universitätsklinikum Münster; Klinik für Unfall-, Handund Wiederherstellungschirurgie.

Infections of the distal phalanx are the most common of all hand infections. There are dorsal localised infections, which develop in the area of the nail and are called paronychia, and palmar infections, which affect the fingertip and are the typical felons. The acute paronychia must be specifically opened depending on the site of infection. Read More

Handchir Mikrochir Plast Chir 2021 Jun 16;53(3):231-236. Epub 2021 Jun 16.

Malteser Krankenhaus Seliger Gerhard Bonn/Rhein-Sieg, Klinik für Hand- und Plastische Chirurgie.

The treatment of infections of the hand is an important part in hand surgery. Despite oft new antibiotic therapy there is a major part of surgical intervention. But there are certain cases in which a conservative treatment is indicated if a closed control is provided. Read More

Orthop Traumatol Surg Res 2021 Jun 5:102982. Epub 2021 Jun 5.

Service de chirurgie de la Main, SOS Main, Hôpitaux universitaires de Strasbourg, Icube CNRS 7357, Université de Strasbourg, 1, avenue Molière, 67000 Strasbourg, France. Electronic address:

Introduction: There is no consensus in the literature, or even within the same team, on the most appropriate treatment option for acute paronychia with abscess formation. The performance of an evaluation of professional practices (EPP) using a clinical audit measures the quality of our practices with the aim of standardizing them. Therefore, the primary objective of this study was to develop a clinical pathway for the management of acute paronychia with abscess formation. Read More

Dermatol Ther 2021 Jul 21;34(4):e15016. Epub 2021 Jun 21.

Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.

An increasing use of beta-blockers in dermatology has been described over the last 10 years, despite the fact that their use in diseases other than infantile hemangiomas is off-label. This review discusses the emerging role of topical beta-blockers in the treatment of infantile hemangioma, but also pyogenic granuloma, Kaposi sarcoma, wounds and nail paronychia. Data in literature demonstrate that topical beta-blockers are a safe and valid therapeutic option in numerous cutaneous diseases. Read More

J Dermatolog Treat 2021 Jun 16:1-6. Epub 2021 Jun 16.

Department of Dermatology, Soonchunhyang University Hospital, Seoul, Korea.

Background: Doxycycline is one of the most prescribed antibiotics by dermatologists. However, the concern regarding adverse events of doxycyline has been rising.

Objective: To detect the adverse events of doxycycline using the Korea Adverse Events Reporting System (KAERS) database from January 2014 to December 2018 through a data mining method. Read More

Asian Pac J Cancer Prev 2021 May 1;22(5):1581-1590. Epub 2021 May 1.

Department of Oncology, Hanoi Medical University, Hanoi, Vietnam.

Background: We aimed to evaluate the effectiveness and tolerability of Afatinib as first-line treatment of advanced epidermal growth factor receptor (EGFR) mutant non small cell lung cancer (NSCLC) in a real-world setting.

Patients And Methods: This is a retrospective study of Vietnamese patients  with advanced EGFR-mutant NSCLC treated with first-line afatinib at the National Cancer Hospital from 1st January 2018 to 31st October 2020. Patients' demographic, clinical and treatment data were captured. Read More

Pediatr Dermatol 2021 May 28. Epub 2021 May 28.

Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.

Background/objectives: Neonatal abstinence syndrome (NAS) incidence continues to rise in the United States due to increasing opioid use disorder in pregnancy. While cutaneous excoriations have been noted in NAS, there is a paucity of literature regarding abnormal nail findings in NAS.

Methods: A retrospective, observational case series was conducted of twelve patients with NAS and abnormal nail findings who were admitted to the neonatal intensive care unit between January 1, 2018, and May 1, 2020. Read More

Dermatol Surg 2021 Jun;47(6):775-779

Department of Dermatology, the University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Paronychia is a common toxicity associated with targeted anticancer therapies. Antibiotics and steroids are the standard treatments for severe paronychia, yet they are often inadequate, prolonging the patient's suffering and resulting in changes to effective cancer therapy.

Objective: This article describes the clinical course of drug-induced paronychia and attempts to identify circumstances under which nail surgery may be beneficial. Read More

An Bras Dermatol 2021 Jul-Aug;96(4):477-481. Epub 2021 May 18.

Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Herpetic whitlow is a viral infection of the fingers caused by the herpes simplex virus. The disease has a bimodal age distribution, affecting children under 10 years of age and young adults between 20 and 30 years old. It can be easily mistaken for panaritium or bacterial cellulitis. Read More

J Dermatolog Treat 2021 May 24:1-5. Epub 2021 May 24.

Department of Medicine, Faculty of Medicine, Division of Dermatology, Skin and Allergy Research Unit, Chulalongkorn University, Bangkok, Thailand.

We evaluated the efficacy and safety of red light LED as an adjuvant treatment for epidermal growth factor receptor inhibitor-induced paronychia. Eight patients were recruited in this randomized, single-blinded controlled trial. They were randomized to receive red-light on one hand or foot 2-3 times/week for 6 weeks while the contralateral side served as controls. Read More

Sex Transm Infect 2021 May 5. Epub 2021 May 5.

Dermatology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.

Thorac Cancer 2021 06 5;12(12):1824-1830. Epub 2021 May 5.

Department of Medical Oncology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Background: Sarcopenia has recently emerged as a new condition with increasing importance in lung cancer patients. The aim of this study was to investigate the influence of sarcopenia on tolerance and efficacy of afatinib.

Methods: We retrospectively evaluated 35 patients with epidermal growth factor receptor (EGFR) mutant advanced non-small cell lung cancer (NSCLC) treated with first-line afatinib. Read More

Cancer Med 2021 Jun 3;10(11):3556-3564. Epub 2021 May 3.

Division of Hematology, Oncology & BMT, Department of Pediatrics, University of British Columbia, Vancouver, Canada.

Purpose: To describe a series of children with extensive PNF or treatment refractory PLGG treated on a compassionate basis with trametinib.

Methods: We report on six patients with NF-1 treated with trametinib on a compassionate basis at British Columbia Children's Hospital since 2017. Data were collected retrospectively from the patient record. Read More

J Dermatol 2021 Jul 23;48(7):1073-1076. Epub 2021 Apr 23.

Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Green nail syndrome (GNS) is a paronychial infection mainly due to Pseudomonas aeruginosa, characterized by green discoloration of the nail plate. Although the diagnosis of GNS may be straightforward with its distinctive color change, the clinical management of the disease can be sometimes confusing, especially when the bacterial culture result is inconsistent. There is, however, a paucity of comprehensive reviews regarding the treatment of GNS in the actual clinical setting. Read More

Eur J Cancer 2021 May 2;149:235-248. Epub 2021 Apr 2.

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Via Giacomo Venezian 1, 20133, Milan, Italy.

Background: The treatment of metastatic non-small-cell lung cancer (mNSCLC) patients with EGFR/HER2 exon 20 insertion mutation (i-mut) remains an unmet clinical need. Poziotinib, a new generation tyrosine kinase inhibitor, is currently under investigation as a potential targeted therapy. This compassionate study of its use aims to describe the activity/toxicity of poziotinib in mNSCLC with EGFR/HER2-exon-20-i-mut. Read More

Skin Appendage Disord 2021 Feb 3;7(2):123-126. Epub 2020 Dec 3.

Department of Dermatology, Ankara Bilkent City Hospital, Ankara, Turkey.

Panitumumab is a recombinant, fully humanized IgG2 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). Panitumumab is indicated for patients with metastatic colorectal cancer with progressive refractory disease. Targeted therapies are well known to be well tolerated; however, they may induce toxicities that are distinct from those of classical chemotherapeutic agents. Read More

Dtsch Arztebl Int 2021 Feb;118(5):65

J Feline Med Surg 2021 Mar 24:1098612X21998612. Epub 2021 Mar 24.

Langford Small Animal Hospital, Langford House, University of Bristol, Bristol, UK.

Case Series Summary: The aim of this case series was to describe the clinical features and treatment of paronychia in cats diagnosed with patellar fracture and dental anomaly syndrome (PADS). Clinical records, photographs, microbiology, cytology and histopathology reports were collected, and follow-up was obtained. Five cats with paronychia were included. Read More

Dermatol Clin 2021 Apr 11;39(2):245-253. Epub 2021 Feb 11.

Department of Dermatology, Radboud University Medical Center, Rene Descartesdreef 1, Nijmegen 6525GL, The Netherlands.

Bacterial and viral infections of the nail unit are very common as primary infections, especially bacterial paronychia and warts, but they can also be superinfections complicating other nail disorders. In many nail unit infections, the clinical presentation is nonspecific: in these cases, diagnostic tests are mandatory before treatment, to avoid spread of the infection and drug resistance. The most common forms of bacterial and viral infections that may affect the nail unit are herein described in detail, with diagnostic and treatment options provided. Read More

Lung Cancer 2021 04 23;154:176-185. Epub 2021 Feb 23.

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China. Electronic address:

Objectives: To compare efficacy and safety of dacomitinib versus gefitinib as first-line therapy for EGFR mutation-positive advanced NSCLC in Asian patients enrolled in the ongoing ARCHER 1050 trial.

Materials And Methods: In this ongoing, randomized, open-label, phase 3 trial (NCT01774721), eligible patients with newly diagnosed advanced EGFR mutation-positive NSCLC were randomized (1:1) to receive oral dacomitinib 45 mg/day or oral gefitinib 250 mg/day. Randomization, by a central computer system, was stratified by race and EGFR mutation type (exon 19 deletion mutation/exon 21 L858R substitution mutation). Read More

Am J Emerg Med 2021 Mar 1;46:34-37. Epub 2021 Mar 1.

Boston Children's Hospital, Department of Emergency Medicine, USA. Electronic address:

Objectives: Little is known regarding the differences in microbiology associated with cellulitis or abscess with or without lymphangitic streaking. The objective of our study is to assess whether there are differences in the pathogens identified from wound cultures of patients with paronychia with and without associated lymphangitis.

Methods: Retrospective cross-sectional study at a tertiary pediatric emergency department over 25 years. Read More

Invest New Drugs 2021 Mar 13. Epub 2021 Mar 13.

Shanghai Henlius Biotech, Inc., Shanghai, China.

Purpose This study aimed to evaluate the safety and pharmacokinetic (PK) profiles of HLX07, a novel, recombinant, humanized anti-epidermal growth factor receptor (EGFR) antibody, in patients with advanced solid cancers who had failed standard therapy or for whom no standard therapy was available. Methods In this prospective, open-label, Phase I dose escalation study, patients aged ≥18 years (≥20 years for patients in Taiwan) with histologically-confirmed metastatic or recurrent epithelial carcinoma that had no K-RAS or B-RAF mutations were enrolled in a '3 + 3' escalation design. HLX07 was administered weekly by 2-h intravenous infusion at doses ranging from 50 to 800 mg. Read More

Rev Soc Bras Med Trop 2021;54. Epub 2021 Mar 8.

Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, AM, Brasil.