81,318 results match your criteria Parkinsonism & Related Disorders [Journal]


A Palm-Worn Device to Quantify Rigidity in Parkinson's Disease.

J Neurosci Methods 2019 Feb 15. Epub 2019 Feb 15.

Bionics Institute, East Melbourne, Victoria, Australia; Department of Medical Bionics, University of Melbourne, East Melbourne, Victoria, Australia.

Background: Parkinsonian rigidity is identified on clinical examination as resistance to passive movement. Measurement of rigidity commonly relies on ordinal rating scales (MDS-UPDRS), however instrumented objective measures may provide greater mechanistic insight.

New Method: We present a palm-worn instrument to objectively quantify rigidity on a continuous scale. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.006DOI Listing
February 2019
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Clinical heterogeneity of frontotemporal dementia and Parkinsonism linked to chromosome 17 caused by MAPT N279K mutation in relation to tau positron emission tomography features.

Mov Disord 2019 Feb 17. Epub 2019 Feb 17.

Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

Background: While mechanistic links between tau abnormalities and neurodegeneration have been proven in frontotemporal dementia and parkinsonism linked to chromosome 17 caused by MAPT mutations, variability of the tau pathogenesis and its relation to clinical progressions in the same MAPT mutation carriers are yet to be clarified.

Objectives: The present study aimed to analyze clinical profiles, tau accumulations, and their correlations in 3 kindreds with frontotemporal dementia and parkinsonism linked to chromosome 17 attributed to the MAPT N279K mutation.

Methods: Four patients with N279K mutant frontotemporal dementia and parkinsonism linked to chromosome 17/MAPT underwent [ C]PBB3-PET to estimate regional tau loads. Read More

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http://dx.doi.org/10.1002/mds.27623DOI Listing
February 2019

Tics and stereotypies: A comparative clinical review.

Parkinsonism Relat Disord 2019 Feb 4. Epub 2019 Feb 4.

Tic and Neurodevelopmental Movements Service (TANDeM), Children's Neurosciences Centre, Evelina London Children's Hospital, Guys and St Thomas' NHS Foundation Trust, London, UK.

Tics and stereotypies are the most common pathological repetitive complex motor behaviors occurring during the neurodevelopmental period. Although they may appear transiently during development without acquiring a pathological status, when they become chronic they may be distressing, socially impairing, or even, in the case of malignant tics, potentially physically harmful. Despite a certain similarity in their phenomenology, physicians should be able to distinguish them for their different variability over time, topographical distribution, association with sensory manifestations, and relationship with environmental triggers. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.005DOI Listing
February 2019

A rare cause of axial worsening in Parkinson's disease: A case of myasthenic pseudo-parkinsonism.

Clin Neurol Neurosurg 2019 Feb 11;179:1-3. Epub 2019 Feb 11.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.

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http://dx.doi.org/10.1016/j.clineuro.2019.02.009DOI Listing
February 2019

Altered functional network topology correlates with clinical measures in very early-stage, drug-naïve Parkinson's disease.

Parkinsonism Relat Disord 2019 Feb 7. Epub 2019 Feb 7.

Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, USA. Electronic address:

Introduction: The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients.

Methods: Functional-MRI data for 16 healthy controls and 20 very early-stage, drug-naïve patients with PD were obtained from the Parkinson's Progression Markers Initiative database after controlling for strict inclusion/exclusion imaging criteria. Connectivity between regions of interest was estimated using Pearson's correlation between averaged time-series, and subsequently a connectivity matrix was obtained for each subject. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.001DOI Listing
February 2019

General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study.

Parkinsonism Relat Disord 2019 Feb 8. Epub 2019 Feb 8.

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Germany. Electronic address:

Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.

Methods: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.019DOI Listing
February 2019

Development of evidence-based quality indicators for deep brain stimulation in patients with Parkinson's disease and first year experience of implementation of a nation-wide registry.

Parkinsonism Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Center, University Würzburg, Clincial Trial Center Würzburg, University Hospital Würzburg, Germany.

Introduction: Deep Brain Stimulation (DBS) is a complex, invasive and cost-intensive therapy that requires a high level of expertise. To date, data on quality of DBS in clinical routine in the German health care system are lacking.

Methods: The development of evidence-based QIs for DBS in PD patients was performed following a standardized process by a multidisciplinary board between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.016DOI Listing
February 2019

Subthalamic and pallidal oscillatory activity in patients with Neurodegeneration with Brain Iron Accumulation type I (NBIA-I).

Clin Neurophysiol 2019 Jan 25;130(4):469-473. Epub 2019 Jan 25.

Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure, ExzellenzCluster, Charité - Universitätsmedizin Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany. Electronic address:

Objectives: Neurodegeneration with Brain Iron Accumulation type I (NBIA-I) is a rare hereditary neurodegenerative disorder with pallidal degeneration leading to disabling generalized dystonia and parkinsonism. Pallidal or subthalamic deep brain stimulation can partially alleviate motor symptoms. Disease-specific patterns of abnormally enhanced oscillatory neuronal activity recorded from the basal ganglia have been described in patients with movement disorders undergoing deep brain stimulation (DBS). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.012DOI Listing
January 2019

Pill swallowing in Parkinson's disease: A prospective study based on flexible endoscopic evaluation of swallowing.

Parkinsonism Relat Disord 2019 Feb 4. Epub 2019 Feb 4.

Center for Clinical Neurosciences, Department of Voice, Speech and Hearing Disorders, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: This study evaluates the prevalence, characteristics, and predictors of the difficulty of swallowing medication in Parkinson's disease (PD).

Methods: In this prospective controlled, cross-sectional cohort study, the ability to swallow four different placebos was assessed using flexible endoscopic evaluation of swallowing (FEES) in 118 PD patients and 32 controls. The association between a patient's swallowing ability for each pill and water, patient characteristics and dopaminergic response was examined. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.002DOI Listing
February 2019

[Drug-induced Parkinsonism].

Rev Esp Geriatr Gerontol 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Geriatría, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.regg.2018.08.004DOI Listing
February 2019

The distribution and risk effect of GBA variants in a large cohort of PD patients from Colombia and Peru.

Parkinsonism Relat Disord 2019 Feb 4. Epub 2019 Feb 4.

Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA; Lerner Research Institute, Genomic Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA. Electronic address:

Background: Mutations in the glucocerebrosidase (GBA) gene are an important risk factor for Parkinson's disease (PD). However, most GBA genetic studies in PD have been performed in patients of European origin and very few data are available in other populations.

Methods: We sequenced the entire GBA coding region in 602 PD patients and 319 controls from Colombia and Peru enrolled as part of the Latin American Research Consortium on the Genetics of Parkinson's disease (LARGE-PD). Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.030DOI Listing
February 2019

The effect of dopamine on response inhibition in Parkinson's disease relates to age-dependent patterns of nigrostriatal degeneration.

Parkinsonism Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

Charité - Universitätsmedizin Berlin, Movement Disorders and Neuromodulation Unit, Department of Neurology, Campus Virchow Klinikum and Campus Mitte, Charitéplatz 1, 10119, Berlin, Germany. Electronic address:

Introduction: Motor but also non-motor effects are modulated by dopamine (DA) in Parkinson's disease (PD). Impaired inhibition has been related to dopamine overdosing of the associative striatum. We compared effects of dopaminergic medication on inhibitory control in patients with young (age at onset <50 years, YOPD) and late onset PD (LOPD) and related them to nigrostriatal degeneration. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.003DOI Listing
February 2019

The organization of the basal ganglia functional connectivity network is non-linear in Parkinson's disease.

Neuroimage Clin 2019 Feb 3;22:101708. Epub 2019 Feb 3.

Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Spain. Electronic address:

The motor symptoms in Parkinson's disease (PD) have been linked to changes in the excitatory/inhibitory interactions of centers involved in the cortical-subcortical closed-loop circuits which connect basal ganglia (BG) and the brain cortex. This approach may explain some motor symptoms of PD but not others, which has driven the study of BG from new perspectives. Besides their cortical-subcortical linear circuits, BG have a number of subcortical circuits which directly or indirectly connect each BG with all the others. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101708DOI Listing
February 2019

Learning from the past and expecting the future in Parkinsonism: Dopaminergic influence on predictions about the timing of future events.

Neuropsychologia 2019 Feb 11. Epub 2019 Feb 11.

Sobell Department of Motor Neuroscience and Movement Disorders, University College London, UK.

The prolonged reaction times seen in Parkinson's disease (PD) have been linked to a dopaminergic-dependent deficit in using prior information to prepare responses, but also have been explained by an altered temporal processing. However, an underlying cognitive mechanism linking dopamine, temporal processing and response preparation remains elusive. To address this, we studied PD patients, with or without medication, and age-matched healthy individuals using a variable foreperiod task requiring speeded responses to a visual stimulus occurring at variable onset-times, with block-wise changes in the temporal predictability of visual stimuli. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283932183061
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http://dx.doi.org/10.1016/j.neuropsychologia.2019.02.003DOI Listing
February 2019
3 Reads

Dementia spectrum disorders: lessons learnt from decades with PET research.

J Neural Transm (Vienna) 2019 Feb 14. Epub 2019 Feb 14.

Neurodegeneration Imaging Group, Maurice Wohl Clinical Neuroscience Institute, 125 Coldharbour Lane, Camberwell, London, SE5 9NU, UK.

The dementia spectrum encompasses a range of disorders with complex diagnosis, pathophysiology and limited treatment options. Positron emission tomography (PET) imaging provides insights into specific neurodegenerative processes underlying dementia disorders in vivo. Here we focus on some of the most common dementias: Alzheimer's disease, Parkinsonism dementias including Parkinson's disease with dementia, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal syndrome, and frontotemporal lobe degeneration. Read More

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http://dx.doi.org/10.1007/s00702-019-01975-4DOI Listing
February 2019
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Case Report: An Incidental Finding of Fahr's Disease in a Patient with Hypochondria.

Cureus 2018 Dec 1;10(12):e3668. Epub 2018 Dec 1.

Neurology, Marcus Neuroscience Institute, Boca Raton, USA.

Idiopathic basal ganglia calcification (IBGC), commonly referred to as Fahr's disease, is a rare neurological disorder characterized by the abnormal, symmetrical, and bilateral calcification of the basal ganglia and other brain regions. Patients typically present in their forties and fifties with various neurologic and/or psychiatric symptoms, including movement disorders, Parkinsonism, psychosis, and depression. The pathophysiology of this disease is not completely understood; however, several gene mutations have been identified in the pathogenesis of Fahr's disease. Read More

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http://dx.doi.org/10.7759/cureus.3668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367120PMC
December 2018

Refining initial diagnosis of Parkinson's disease after follow-up: A 4-year prospective clinical and magnetic resonance imaging study.

Mov Disord 2019 Feb 13. Epub 2019 Feb 13.

Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy.

Background: No prospective study of patients with Parkinson's disease (PD) has investigated the appearance of vertical gaze abnormalities, a feature suggestive of progressive supranuclear palsy (PSP).

Objective: To identify, within a cohort of patients with an initial diagnosis of PD, those who developed vertical gaze abnormalities during a 4-year follow-up, and to investigate the performance of new imaging biomarkers in predicting vertical gaze abnormalities.

Methods: A total of 110 patients initially classified as PD and 74 controls were enrolled. Read More

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http://dx.doi.org/10.1002/mds.27621DOI Listing
February 2019

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.

Neurotherapeutics 2019 Feb 12. Epub 2019 Feb 12.

Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, BMC F11, Lund, Sweden.

Pridopidine is a small molecule in clinical development for the treatment of Huntington's disease. It was recently found to have high binding affinity to the sigma-1 receptor, a chaperone protein involved in cellular defense mechanisms and neuroplasticity. Here, we have evaluated the neuroprotective and neurorestorative effects of pridopidine in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of parkinsonism in mice. Read More

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http://dx.doi.org/10.1007/s13311-018-00699-9DOI Listing
February 2019

Dynamics of Parkinson's Disease Multimodal Complex Treatment in Germany from 2010⁻2016: Patient Characteristics, Access to Treatment, and Formation of Regional Centers.

Cells 2019 Feb 11;8(2). Epub 2019 Feb 11.

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44801 Bochum, Germany.

Parkinson's disease (PD) is currently the world's fastest-growing neurological disorder. It is characterized by motor and non-motor symptoms which progressively lead to significant clinical impairment, causing a high burden of disease. In addition to pharmacological therapies, various non-pharmacological treatment options are available. Read More

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http://dx.doi.org/10.3390/cells8020151DOI Listing
February 2019

Changes in Dendritic Spine Density and Inhibitory Perisomatic Connectivity onto Medium Spiny Neurons in L-Dopa-Induced Dyskinesia.

Mol Neurobiol 2019 Feb 11. Epub 2019 Feb 11.

Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Using bacterial artificial chromosome-double transgenic mice expressing tdTomato in D1 receptor-medium spiny neurons (MSNs) and enhanced green fluorescent protein in D2 receptor-MSNs, we have studied changes in spine density and perisomatic GABAergic boutons density in MSNs of both the D1R and D2R pathways, in an experimental model of parkinsonism (mouse injected with 6-hydroxydopamine in the medial forebrain bundle), both in the parkinsonian and dyskinetic condition induced by L-DOPA treatment. To assess changes in perisomatic GABAergic connectivity onto MSNs, we measured the number of contacts originated from parvalbumin (PV)-containing striatal "fast-spiking" interneurons (FSIs), the major component of a feed-forward inhibition mechanism that regulates spike timing in MSNs, in both cell types as well as the number of vesicular GABA transporter (VGAT) contacts. Furthermore, we determined changes in PV-immunoreactive cell density by PV immunolabeling combined with Wisteria floribunda agglutinin (WFA) labeling to detect FSI in a PV-independent manner. Read More

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http://dx.doi.org/10.1007/s12035-019-1515-4DOI Listing
February 2019
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Tc-TRODAT-1 SPECT Showing Dopaminergic Deficiency in a Patient with Spinocerebellar Ataxia Type 10 and Parkinsonism.

Mov Disord Clin Pract 2019 Jan 16;6(1):85-87. Epub 2018 Nov 16.

Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas Federal University of Paraná Curitiba PR Brazil.

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http://dx.doi.org/10.1002/mdc3.12700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335547PMC
January 2019

Substantia Nigra Swelling and Dentate Nucleus T2 Hyperintensity May Be Early Magnetic Resonance Imaging Signs of β-Propeller Protein-Associated Neurodegeneration.

Mov Disord Clin Pract 2019 Jan 9;6(1):51-56. Epub 2018 Nov 9.

Neuroradiology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy.

Background And Methods: Mutations in cause β-propeller protein-associated neurodegeneration (BPAN), a type of neurodegeneration with brain iron accumulation (NBIA). We reviewed clinical and MRI findings in 4 patients with de novo mutations.

Results: Psychomotor delay and movement disorders were present in all cases; early-onset epileptic encephalopathy was present in 3. Read More

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http://dx.doi.org/10.1002/mdc3.12693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335537PMC
January 2019

22q11.2 Deletion Syndrome-Associated Parkinson's Disease.

Mov Disord Clin Pract 2019 Jan 9;6(1):11-16. Epub 2018 Nov 9.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease Research Toronto Western Hospital and University of Toronto Toronto Ontario Canada.

Background: 22q11.2 deletion syndrome (22q11.2DS) is a multisystem condition associated with an increased risk of early-onset Parkinson's disease (PD). Read More

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http://dx.doi.org/10.1002/mdc3.12687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335527PMC
January 2019
1 Read

Linaclotide and Prucalopride for Management of Constipation in Patients with Parkinsonism.

Mov Disord Clin Pract 2018 Mar-Apr;5(2):218-220. Epub 2018 Jan 28.

Division of Gastroenterology Department of Medicine University of Toronto Toronto Ontario Canada.

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http://dx.doi.org/10.1002/mdc3.12577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336416PMC
January 2018
1 Read

Long Lag Between Drug-induced Parkinsonism and Idiopathic Parkinson's Disease in Idiopathic REM Sleep Behavior Disorder.

Mov Disord Clin Pract 2018 Mar-Apr;5(2):203-205. Epub 2018 Jan 10.

Department of Neurology and Neurosurgery McGill University Montreal Quebec Canada.

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http://dx.doi.org/10.1002/mdc3.12576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336185PMC
January 2018
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Dopamine transporter imaging for the diagnosis of multiple system atrophy cerebellar type.

Parkinsonism Relat Disord 2019 Feb 5. Epub 2019 Feb 5.

Service de Neurologie, CRMR Atrophie Multisystématisée, CHU Bordeaux, 33000, Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000, Bordeaux, France; Dept. of Medicine, University of Otago, Christchurch, and New Zealand Brain Research Institute, Christchurch, New Zealand. Electronic address:

Introduction: The added value of dopamine transporter SPECT (DAT-SPECT) for the diagnosis of "possible" multiple system atrophy of the cerebellar type (MSA-C) remains unknown.

Methods: We reviewed retrospectively the charts of 128 consecutive patients with a clinical diagnosis of MSA-C who were seen between 2007 and 2016 at the French Reference Center for MSA. The main objective was to evaluate the proportion of patients for whom the diagnosis of "possible" MSA-C was made because of a positive DAT-SPECT. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.006DOI Listing
February 2019

Movement Disorders Emergencies.

Semin Neurol 2019 Feb 11;39(1):125-136. Epub 2019 Feb 11.

Movement Disorders Division, Department of Neurology, Johns Hopkins, Baltimore, Maryland.

Many acute and potentially life-threatening medical conditions have hyperkinetic or hypokinetic movement disorders as their hallmark. Here we review the clinical phenomenology, and diagnostic principles of neuroleptic malignant syndrome, malignant catatonia, serotonin syndrome, Parkinsonism hyperpyrexia, acute parkinsonism, acute chorea-ballism, drug-induced dystonia, and status dystonicus. In the absence of definitive lab tests and imaging, only a high index of clinical suspicion, awareness of at-risk populations, and variations in clinical presentation can help with diagnosis. Read More

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http://dx.doi.org/10.1055/s-0038-1677050DOI Listing
February 2019
2 Reads

MAPT mutations, tauopathy, and mechanisms of neurodegeneration.

Lab Invest 2019 Feb 11. Epub 2019 Feb 11.

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent pathological feature is the aberrant aggregation and inclusion formation of the microtubule-associated protein tau. Because of the pathological association, these disorders are often referred to as tauopathies. Mutations in the MAPT gene that encodes tau can cause frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), providing the clearest evidence that tauopathy plays a causal role in neurodegeneration. Read More

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http://dx.doi.org/10.1038/s41374-019-0197-xDOI Listing
February 2019

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI).

Parkinsonism Relat Disord 2019 Jan 31. Epub 2019 Jan 31.

Northwestern University Feinberg School of Medicine, USA. Electronic address:

Objective: To determine the feasibility, safety and tolerability of lumbar punctures (LPs) in research participants with early Parkinson disease (PD), subjects without evidence of dopaminergic deficiency (SWEDDs) and healthy volunteers (HC).

Background: Cerebrospinal fluid (CSF) analysis is becoming an essential part of the biomarkers discovery effort in PD with still limited data on safety and feasibility of serial LPs in PD participants.

Design/methods: Parkinson's Progression Marker Initiative (PPMI) is a longitudinal observation study designed to identify PD progression biomarkers. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2018.12.025DOI Listing
January 2019
1 Read

Co-morbid demyelinating lesions and atypical clinical features in a patient with Parkinson's disease.

Parkinsonism Relat Disord 2019 Feb 2. Epub 2019 Feb 2.

Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain; Institute of Neurology, Medical University of Vienna, Allgemeines Krankenhaus der Stadt Wien, Waehringer Guertel 18-20, 1090, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.015DOI Listing
February 2019
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Flunarizine related movement disorders: a nationwide population-based study.

Sci Rep 2019 Feb 8;9(1):1705. Epub 2019 Feb 8.

Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.

Flunarizine (fz) causes side effects such as movement disorders (MDs). We investigated risk factors associated with fz-related MDs. Participants were recruited from the longitudinal health insurance databases and included patients who took fz for more than 1 month. Read More

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http://dx.doi.org/10.1038/s41598-018-37901-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368567PMC
February 2019

What Promises the CJD Diagnosis in a Case of Rapidly Progressive Dementia?

J Alzheimers Dis Parkinsonism 2018 30;8(5). Epub 2018 Oct 30.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.

Background: Developing methods for accurately diagnosing prion diseases has been a challenge in the search for successful diagnosis and treatment of rapidly progressive dementia. prion diseases are rare. However, they should be considered in the differential diagnosis. Read More

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http://dx.doi.org/10.4172/2161-0460.1000452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362841PMC
October 2018
1 Read

Pseudobulbar Affect in Parkinsonian Disorders: A Review.

J Mov Disord 2019 Jan 30;12(1):14-21. Epub 2019 Jan 30.

Stony Brook University School of Medicine, Stony Brook, NY.

Pseudobulbar affect (PBA) is a neurological symptom of inappropriate and uncontrollable laughter or crying that occurs secondary to a variety of neurological conditions, including parkinsonian disorders. PBA is a socially and emotionally debilitating symptom that has been estimated to affect 3.6% to 42. Read More

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http://dx.doi.org/10.14802/jmd.18051DOI Listing
January 2019
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Abnormal Eye Movements in Parkinsonism and Movement Disorders.

J Mov Disord 2019 Jan 30;12(1):1-13. Epub 2019 Jan 30.

Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan.

Abnormal eye movements are commonly observed in movement disorders. Ocular motility examination should include bedside evaluation and laboratory recording of ocular misalignment, involuntary eye movements, including nystagmus and saccadic intrusions/oscillations, triggered nystagmus, saccades, smooth pursuit (SP), and the vestibulo-ocular reflex. Patients with Parkinson's disease (PD) mostly show hypometric saccades, especially for the selfpaced saccades, and impaired SP. Read More

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http://dx.doi.org/10.14802/jmd.18034DOI Listing
January 2019

Widespread microglial activation in multiple system atrophy.

Mov Disord 2019 Feb 6. Epub 2019 Feb 6.

Departments of Nulcear Medicine and Geriatric Medicine, University Hospital Essen, Germany.

Background: The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [ C](R)-PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients.

Methods: Fourteen patients with the parkinsonian phenotype of MSA (MSA-P) with a mean disease duration of 2. Read More

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http://dx.doi.org/10.1002/mds.27620DOI Listing
February 2019
1 Read

Emerging links between pediatric lysosomal storage diseases and adult parkinsonism.

Mov Disord 2019 Feb 6. Epub 2019 Feb 6.

Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Lysosomal storage disorders comprise a clinically heterogeneous group of autosomal-recessive or X-linked genetic syndromes caused by disruption of lysosomal biogenesis or function resulting in accumulation of nondegraded substrates. Although lysosomal storage disorders are diagnosed predominantly in children, many show variable expressivity with clinical presentations possible later in life. Given the important role of lysosomes in neuronal homeostasis, neurological manifestations, including movement disorders, can accompany many lysosomal storage disorders. Read More

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http://dx.doi.org/10.1002/mds.27631DOI Listing
February 2019
1 Read

Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy.

Mov Disord 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Mayo Clinic Rochester, Rochester, Minnesota, USA.

Background: In 2017, the International Parkinson and Movement Disorder Society put forward new clinical criteria for the diagnosis of PSP, recognizing diverse PSP phenotypes. In this study, we compared the sensitivity and specificity of the new criteria with the National Institutes of Neurological Disease and Society for Progressive Supranuclear Palsy criteria at different times.

Methods: Patients with clinical parkinsonism, clinical and/or neuropathological diagnosis of PSP, were identified from the Society for Progressive Supranuclear Palsy brain bank. Read More

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http://dx.doi.org/10.1002/mds.27619DOI Listing
February 2019
1 Read

Management of delirium in Parkinson's disease.

J Neural Transm (Vienna) 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.

Delirium is an acute and fluctuating disturbance of attention and awareness. Pre-existing cognitive disturbances or dementia are the most significant risk factors for developing delirium and precipitating factors such as drug treatment, infections, trauma, or surgery may trigger delirium. Patients with Parkinson's disease (PD) are at an increased risk for delirium which may be underdiagnosed due to phenomenological overlap between delirium and chronic neuropsychiatric features of PD or side effects of dopaminergic medication. Read More

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http://dx.doi.org/10.1007/s00702-019-01980-7DOI Listing
February 2019
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The Diagnostic Scope of Sensor-Based Gait Analysis in Atypical Parkinsonism: Further Observations.

Front Neurol 2019 22;10. Epub 2019 Jan 22.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Differentiating idiopathic Parkinson's disease (IPD) from atypical Parkinsonian disorders (APD) is challenging, especially in early disease stages. Postural instability and gait difficulty (PIGD) are substantial motor impairments of IPD and APD. Clinical evidence implies that patients with APD have larger PIGD impairment than IPD patients. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00005
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http://dx.doi.org/10.3389/fneur.2019.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349719PMC
January 2019
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Physical activity mediates the association between striatal dopamine transporter availability and cognition in Parkinson's disease.

Parkinsonism Relat Disord 2019 Jan 31. Epub 2019 Jan 31.

Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, USA; Department of Radiology, University of North Carolina at Chapel Hill, USA. Electronic address:

Objective: Associations between cognition and nigrostriatal dopaminergic deficits in Parkinson's disease have been documented in the literature, but are incompletely understood. Here we studied the extent to which physical activity mediates the relationship between striatal dopamine transporter availability and global cognition among patients with Parkinson's disease.

Methods: Data from 174 patients from a multi-center study were analyzed using regression-based mediation analysis. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.027DOI Listing
January 2019
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Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation.

Acta Neuropathol 2019 Feb 5. Epub 2019 Feb 5.

Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disease that is characterized by varying degrees of cerebellar dysfunction and Parkinsonism. The neuropathological hallmark of MSA is alpha-synuclein (AS)-positive glial cytoplasmic inclusions (GCIs). Although severe neuronal loss (NL) is also observed in MSA, neuronal inclusions (NIs) are rare compared to GCIs, such that the pathological mechanism of NL in MSA is unclear. Read More

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http://dx.doi.org/10.1007/s00401-019-01961-wDOI Listing
February 2019

Corticobasal Syndrome: Neuroimaging and Neurophysiological Advances.

Eur J Neurol 2019 Feb 5. Epub 2019 Feb 5.

IRCCS Neuromed Institute, Pozzilli, IS.

Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R-tau protein deposition in several brain regions that clinically manifests itself as a heterogeneous atypical parkinsonism typically expressing in the adulthood. The prototypical clinical phenotype of CBD is corticobasal syndrome (CBS). Important insights into the pathophysiological mechanisms underlying motor and higher cortical symptoms in CBS have been gained by using advanced neuroimaging and neurophysiological techniques. Read More

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http://dx.doi.org/10.1111/ene.13928DOI Listing
February 2019

Altered transposition asymmetry in serial ordering in early Parkinson's disease.

Parkinsonism Relat Disord 2019 Jan 30. Epub 2019 Jan 30.

Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Electronic address:

Introduction: The ability to arrange thoughts and actions in an appropriate serial order is impaired in Parkinson's disease (PD). However, it is unclear how serial order is represented and manipulated and how the representation or manipulation is altered in the early stages of PD. We aimed to analyze the pattern of performance errors in serial ordering versus serial recall in nondemented PD patients with mild clinical symptoms and healthy adults to identify the underlying principles of serial ordering. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.028DOI Listing
January 2019
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End of life planning in parkinsonian diseases.

Parkinsonism Relat Disord 2019 Jan 30. Epub 2019 Jan 30.

Parkinson and Other Movement Disorders Center, University of California San Diego, Department of Neurosciences, San Diego, CA, USA. Electronic address:

Introduction: The utilization of advance directives in individuals with Parkinson's disease (PD) and atypical parkinsonian disorders (APD) and their caregivers requires further investigation. This study determined the utilization rates of four forms of advance directives: living will, durable power of attorney, durable power of attorney for healthcare, and medical orders in these individuals. We hypothesized that having a neurodegenerative parkinsonian disorder or exposure to these disorders would increase the likelihood of having advance directives. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.026DOI Listing
January 2019
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Associations between daily-living physical activity and laboratory-based assessments of motor severity in patients with falls and Parkinson's disease.

Parkinsonism Relat Disord 2019 Jan 29. Epub 2019 Jan 29.

Center for the study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel; Department of Physical Therapy, Sackler Faculty of Medicine, Israel; Sagol School of Neuroscience, Tel Aviv University, Israel; Rush Alzheimer's Disease Center and Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA. Electronic address:

Introduction: Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.022DOI Listing
January 2019
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Deep brain stimulation for dystonia-choreoathetosis in cerebral palsy: Pallidal versus thalamic stimulation.

Parkinsonism Relat Disord 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurosurgery, Hannover Medical School, Germany.

Introduction: Dystonia-choreoathetosis is common in patients with cerebral palsy, and medical treatment is mostly unsatisfactory. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has shown some effect, but there is still a need to optimize treatment strategies. We aimed to assess whether the thalamic ventral intermediate nucleus (Vim) might be an alternative DBS target in dystonia-choreoathetosis. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.029DOI Listing
January 2019
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Glutamate And Gaba Neurotransmission Are Increased In Paraventricular Nucleus Of Hypothalamus In Rats Induced To 6-OHDA Parkinsonism: Involvement Of nNOS.

Acta Physiol (Oxf) 2019 Feb 4:e13264. Epub 2019 Feb 4.

Departament of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina - PR, Brazil.

Aim: Parkinson's disease (PD) is a progressive neurodegenerative disease that manifests itself clinically after reaching an advanced pathological stage. Besides motor signals, PD patients present cardiovascular and autonomic alterations. Recent data showed that rats induced to Parkinsonism by 6-hydroxydopamine (6-OHDA) administration in the substantia nigra pars compacta (SNpc) showed lower mean arterial pressure (MAP) and heart rate (HR), as reduction in sympathetic modulation. Read More

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http://dx.doi.org/10.1111/apha.13264DOI Listing
February 2019

Role of ANO3 mutations in dystonia: A large-scale mutational screening study.

Parkinsonism Relat Disord 2019 Jan 2. Epub 2019 Jan 2.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address:

Background: The role of ANO3 variants as a monogenic cause of dystonia is still under debate because of its relatively high frequency also in controls.

Objective: To screen >1000 patients with movement disorders for rare ANO3 variants.

Methods: We searched for rare ANO3 variants in 729 dystonia and 294 Parkinson's disease (PD) patients using a gene panel. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2018.12.030DOI Listing
January 2019