125 results match your criteria Parkinson-Plus Syndromes


The Swallow Tail Sign of Substantia Nigra: A Case-Control Study to Establish Its Role in Diagnosis of Parkinson Disease on 3T MRI.

J Neurosci Rural Pract 2022 Apr 9;13(2):181-185. Epub 2022 Feb 9.

Department of Radiodiagnosis, King George's Medical University, Lucknow, Uttar Pradesh, India.

 The loss of swallow tail sign (STS) has been studied for the diagnosis of Parkinson's disease (PD). The study aims to establish the role of STS on high-resolution 3D susceptibility-weighted images (SWI) on 3T MRI in clinically diagnosed cases of PD and compare with control population.  Forty-five patients with clinically diagnosed PD and Parkinson plus syndrome (PPS) formed the study group and were compared with 45 controls without any neurological disease and normal brain magnetic resonance imaging (MRI). Read More

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Diffusion Tensor Imaging for the differential diagnosis of Parkinsonism by machine learning.

Biomed J 2022 Jun 4. Epub 2022 Jun 4.

Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. Electronic address:

Background: There are currently no specific tests for either idiopathic Parkinson's disease or Parkinson-plus syndromes. The study aimed to investigate the diagnostic performance of features extracted from the whole brain using diffusion tensor imaging concerning parkinsonian disorders.

Materials And Methods: The retrospective data yielded 625 participants (average age: 61. Read More

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Clinical Aspects of the Differential Diagnosis of Parkinson's Disease and Parkinsonism.

J Clin Neurol 2022 May;18(3):259-270

Department of Neurology, Chung-Ang University College of Medicine, Seoul, Korea.

Parkinsonism is a clinical syndrome presenting with bradykinesia, tremor, rigidity, and postural instability. Nonmotor symptoms have recently been included in the parkinsonian syndrome, which was traditionally associated with motor symptoms only. Various pathologically distinct and unrelated diseases have the same clinical manifestations as parkinsonism or parkinsonian syndrome. Read More

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Association of white mater lesions with orthostatic hypotension.

Am J Transl Res 2022 15;14(4):2410-2418. Epub 2022 Apr 15.

Department of Radiology, Beijing Tiantan Hospital, Capital Medical University Beijing, China.

Objective: To reveal the cerebral hypoperperfusion characteristics of White matter lesions (WMLs), we monitored the blood pressure (BP) fluctuation in patients with orthostatic hypotension (OH) and WMLs.

Methods: A total of 2265 syncope patients were enrolled in this retrospective study. Clinical outcomes of brain MRI or CT, tilt test and continuous electrocardiogram monitoring were reviewed. Read More

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Parkinsonism in multiple sclerosis patients: A prospective observational study.

Mult Scler Relat Disord 2022 Jun 10;62:103796. Epub 2022 Apr 10.

Case Westerns Reserve University School of Medicine, Cleveland, OH, USA; Multiple Sclerosis and Neuroimmunology Program, Parkinson's and Movement Disorders Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. Electronic address:

Background: Rare cases of coexisting multiple sclerosis and parkinsonism have been reported in the literature. However, the true prevalence, clinical characteristics, and causal relation between the two entities have not been systematically evaluated.

Objective: To evaluate the prevalence of parkinsonism in patients with multiple sclerosis and examine the causal relationship, if any. Read More

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Spontaneous posterior dislocation of the cataractous lens in a patient with Parkinson-plus syndrome.

Am J Ophthalmol Case Rep 2022 Mar 22;25:101286. Epub 2022 Jan 22.

Dr. Shroff's Charity Eye Hospital, 5027, Kedar Nath Road, Daryagunj, New Delhi, Delhi, 110006, India.

Purpose: To report a case of unilateral posterior dislocation of the cataractous lens and subluxation of the lens in the fellow eye of a patient with Parkinson-plus syndrome.

Observations: A 67-year-old-man who was a known case of Parkinson-plus syndrome on long-term dopamine agonists and anti-psychotic medications demonstrated apraxia of lid opening associated with moderate-to-severe blepharospasm. He had unilateral posterior dislocation of the cataractous lens and subluxation of the lens in the fellow eye with no prior history of trauma or other known ocular risk factors. Read More

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Therapeutic Application of rTMS in Atypical Parkinsonian Disorders.

Behav Neurol 2021 23;2021:3419907. Epub 2021 Dec 23.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

The terms atypical parkinsonian disorders (APDs) and Parkinson plus syndromes are mainly used to describe the four major entities of sporadic neuronal multisystem degeneration: progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), and dementia with Lewy bodies (LBD). APDs are characterized by a variety of symptoms and a lack of disease modifying therapies; their treatment thus remains mainly symptomatic. Brain stimulation via repetitive transcranial magnetic stimulation (rTMS) is a safe and noninvasive intervention using a magnetic coil, and it is considered an alternative therapy in various neuropsychiatric pathologies. Read More

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January 2022

Multiple System Atrophy Caregivers' Experience: A Mixed Methods Study.

Can J Neurol Sci 2021 Nov 8:1-11. Epub 2021 Nov 8.

Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Background: Multiple system atrophy (MSA) is a rare Parkinson-plus syndrome with rapid progression and a high symptom burden. The experience of caregivers of people with MSA has not been closely examined. We therefore sought to document the impact of MSA on caregivers using a mixed methods approach. Read More

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November 2021

Alteration of Mitochondrial Function in Oxidative Stress in Parkinsonian Neurodegeneration: A Cross-Sectional Study.

Ann Indian Acad Neurol 2021 Jul-Aug;24(4):506-512. Epub 2021 Apr 21.

Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.

Context: Appropriate mitochondrial function and oxidative balance are critical to neuronal survival. Accumulation of reactive oxygen species leads to oxidative stress that can cause free radical damage to biomolecules of the cell components and the molecules in the cellular milieu that eventually lead to a variety of chronic diseases including neurodegenerative disorders. Mitochondrial dysfunction initiates neuronal apoptosis thereby leading to neurodegenerative diseases including Parkinson's disease (PD). Read More

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An atypical case of corticobasal syndrome with psychotic depression and delusional jealousy.

Neurocase 2021 10 30;27(5):425-429. Epub 2021 Sep 30.

Department of Neurology, University of Health Sciences Erenköy Mental Health and Neurological Diseases Training and Research Hospital, Istanbul, Turkey.

Corticobasal syndrome (CBS) is one of the Parkinson-plus disorders. While initially defined as a movement disorder rather than cognition, it is now known that CBS is related to various psychiatric symptoms. We describe a patient clinically diagnosed with CBS whose initial presentation was psychiatric and rather atypical. Read More

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October 2021

Plasma neurofilament light chain level and orthostatic hypotension in early Parkinson's disease.

J Neural Transm (Vienna) 2021 12 27;128(12):1853-1861. Epub 2021 Sep 27.

Department of Neurology, Parkinson Center, Ajou University School of Medicine, Suwon, Republic of Korea.

To delineate the impact of non-motor markers (REM sleep behavior disorder (RBD), orthostatic hypotension (OH), cardiac sympathetic denervation, hyposmia) on neuronal injury in early-stage Parkinson's disease (PD), we measured the plasma neurofilament light chain (NFL) level of PD patients and evaluated its relationship with these markers. The study population comprised a cohort of 77 patients with PD and 54 controls. OH was assessed using 5-min head-up tilt-table test. Read More

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December 2021

Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study.

Brain 2022 Mar;145(1):340-348

Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0SZ, UK.

The relationship between in vivo synaptic density and molecular pathology in primary tauopathies is key to understanding the impact of tauopathy on functional decline and in informing new early therapeutic strategies. In this cross-sectional observational study, we determine the in vivo relationship between synaptic density and molecular pathology in the primary tauopathies of progressive supranuclear palsy and corticobasal degeneration as a function of disease severity. Twenty-three patients with progressive supranuclear palsy and 12 patients with corticobasal syndrome were recruited from a tertiary referral centre. Read More

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Predicting Long-Term Outcome of Patients of Early Parkinsonism with Acute Levodopa Challenge Test.

Neurol India 2021 Mar-Apr;69(2):430-434

Department of Neurology, Bangur Institute of Neuroscience and Institute of Post Graduate Medical Education and Research (IPGME&R), Kolkata, West Bengal, India.

Objectives: The aim of this study was to evaluate the sensitivity and specificity of various outcomes of acute levodopa challenge test (ALCT) namely improvement of motor function, development of dyskinesia and intolerance; to predict the diagnosis of idiopathic Parkinson's disease (IPD) or Parkinson-plus syndrome; to predict levodopa responsiveness and levodopa-induced dyskinesia (LID) during long-term therapy.

Methods: ALCT was performed on 89 patients with parkinsonism of <2 years and were followed up for 18 months. Improvement of UPDRSm by ≥30% was considered positive. Read More

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High prevalence of serum anti-NH-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome.

J Neurol 2021 Nov 15;268(11):4291-4295. Epub 2021 Apr 15.

Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: Hashimoto's encephalopathy with serum anti-NH-terminal of α-enolase (NAE) antibodies occasionally displays clinical symptoms such as cerebellar ataxia and parkinsonism. We studied the frequency of anti-NAE antibodies in patients with Parkinson-plus syndrome.

Methods: We examined the positive rates of anti-NAE antibodies in 47 patients with multiple system atrophy (MSA), 29 patients with Parkinson's disease (PD), eight patients with corticobasal syndrome (CBS), and 18 patients with progressive supranuclear palsy (PSP) using conventional immunoblot analysis. Read More

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November 2021

Identification of GBA mutations among neurodegenerative disease patients from eastern India.

Neurosci Lett 2021 04 9;751:135816. Epub 2021 Mar 9.

S. N. Pradhan Centre for Neurosciences, University of Calcutta, Kolkata, India. Electronic address:

Introduction: GBA mutations have been reported in PD, PDD and DLB - but not associated with cognitive impairment for example in PSP, AD or MSA. However, frequencies of GBA mutations are ethnicity dependent. The present study aims to identify commonly reported GBA mutations (mostly from Asia), among eastern Indian patients with neurodegenerative disorders. Read More

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Hyperhomocysteinemia and Dementia Associated With Severe Cortical Atrophy, but No Amyloid Burden.

J Geriatr Psychiatry Neurol 2022 01 19;35(1):57-61. Epub 2021 Jan 19.

Regionale Brain Aging Center, Department of Medicine (DIMED), University of Padova, Padova, Italy.

We report a case of a 77 years old patient who was admitted to our memory clinic because of progressive gait impairment and amnestic cognitive decline associated with extrapyramidal symptoms and behavioral changes. The clinical picture was consistent with a possible diagnosis of Alzheimer's Disease associated with parkinsonian symptoms or with a Parkinson Plus syndrome. After a complete investigation, she was found to have a high plasma level of homocysteine due to homozygous methylene-tetrahydrofolate reductase (MTHFR) gene C665 T polymorphism, cognitive and motor impairment were associated with a severe cortical atrophy and mild subcortical vascular disease. Read More

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January 2022

Diagnostic performance of loss of nigral hyperintensity on susceptibility-weighted imaging in parkinsonism: an updated meta-analysis.

Eur Radiol 2021 Aug 15;31(8):6342-6352. Epub 2021 Jan 15.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Olympic-ro 33, Seoul, 05505, Republic of Korea.

Objectives: To evaluate diagnostic performance of loss of nigral hyperintensity on SWI in differentiating idiopathic Parkinson's disease (IPD) or primary parkinsonism (including IPD and Parkinson-plus syndrome) from healthy/disease controls.

Methods: MEDLINE/PubMed and EMBASE databases were searched to identify original articles investigating the diagnostic performance of loss of nigral hyperintensity for differentiating IPD or primary parkinsonism from healthy/disease control, up to April 3, 2020. Pooled sensitivity and specificity were calculated using a bivariate random-effects model. Read More

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Comparative Performance of 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT Imaging in Patients With Parkinson's Disease, Parkinson-Plus Syndrome, and Essential Tremor.

Clin Nucl Med 2021 Feb;46(2):95-102

From the Departments of Nuclear Medicine.

Purpose: The aim of this study was to assess the utility of presynaptic dopaminergic imaging using 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT and compare their performance in Parkinson's disease (PD), Parkinson-plus syndrome (PPS), and essential tremor (ET).

Patients And Methods: A total of 103 patients (PD = 48, PPS = 19, and ET = 36) were enrolled prospectively. Hoehn and Yahr (H&Y) staging and MDS-UPDRS (Movement Disorder Society-Sponsored Revision of Unified Parkinson's Disease Rating Scale) were done for PD and PPS cases. Read More

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February 2021

Multimodal analysis of gene expression from postmortem brains and blood identifies synaptic vesicle trafficking genes to be associated with Parkinson's disease.

Brief Bioinform 2021 07;22(4)

Head of Department of Neurology, Zhujiang Hospital, Southern Medical University, China.

Objective: We aimed to identify key susceptibility gene targets in multiple datasets generated from postmortem brains and blood of Parkinson's disease (PD) patients and healthy controls (HC).

Methods: We performed a multitiered analysis to integrate the gene expression data using multiple-gene chips from 244 human postmortem tissues. We identified hub node genes in the highly PD-related consensus module by constructing protein-protein interaction (PPI) networks. Read More

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Role of variant p.Gly2019Ser in patients with Parkinsonism.

Indian J Med Res 2020 06;151(6):592-597

S.N. Pradhan Centre for Neurosciences, University of Calcutta, Kolkata, India.

Background & Objectives: Parkinsonian disorder, including Parkinson's disease (PD), is an aetiologically complex neurodegenerative disorder. Mutations in leucine-rich repeat kinase 2 (LRRK2) gene have been implicated in an autosomal dominant form of PD with variable penetrance. The identification of a common LRRK2 variant (p. Read More

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Detailed Anatomical Volumetric Study of Deep Nuclei of Brain and Other Structures Between Parkinson's Disease Patients Who Had Deep Brain Stimulation and Control Group.

Malays J Med Sci 2020 May 30;27(3):53-60. Epub 2020 Jun 30.

Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Background: Deep brain stimulation (DBS) was pioneered by Neuroscience team of Hospital Universiti Sains Malaysia (HUSM) nearly a decade ago to treat advanced medically refractory idiopathic Parkinson's disease (IPD) patients.

Objectives: Brain volume reduction occurs with age, especially in Parkinson plus syndrome or psychiatric disorders. We searched to define the degree of volume discrepancy in advanced IPD patients and correlate the anatomical volumetric changes to motor symptoms and cognitive function. Read More

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Dysphagia in Parkinsonism: Prevalence, Predictors and Correlation with Severity of Illness Fasting).

J Assoc Physicians India 2020 May;68(5):22-25

Associate Professor, Department of Medicine, LTMMC and GH, Mumbai, Maharashtra.

Introduction: Dysphagia is frequently present in Parkinsonian syndromes and is associated with increased morbidity and mortality. Early identification of swallowing dysfunction is critical to minimize complications like aspiration pneumonia and malnutrition. Published prevalence rates for dysphagia in Parkinsonian syndromes vary widely with a very few studies from India. Read More

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Overview of sleep disturbances and their management in Parkinson plus disorders.

J Neurol Sci 2020 Aug 8;415:116891. Epub 2020 May 8.

Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka 560029, India. Electronic address:

Sleep disturbance is one of the commonly reported non-motor symptoms in patients with Parkinson's disease (PD) as well as in Parkinson plus disorders such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS). Although there is a wealth of literature on sleep disturbances in PD, the same is not robust on the Parkinson plus disorders. This article aims to comprehensively review the sleep disturbances in Parkinson plus disorders. Read More

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DCTN1-related Parkinson-plus disorder (Perry syndrome).

Pract Neurol 2020 Aug 20;20(4):317-319. Epub 2020 May 20.

Department of Neurology, St George's Hospital, London, UK

Dynactin-1 (DCTN1)-related Parkinson-plus disorder (Perry syndrome) is an autosomal dominant neurodegenerative disorder characterised by levodopa-resistant parkinsonism, weight loss, mood change and central hypoventilation. Ventilatory insufficiency is the predominant cause of death. It has been previously described in 87 people from 20 families with a worldwide distribution. Read More

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Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity.

Acta Neuropathol Commun 2020 02 4;8(1):11. Epub 2020 Feb 4.

Cambridge University Centre for Parkinson-plus and Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge, CB2 0SZ, UK.

The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour. Neurodegeneration and pathological aggregation of tau protein in the locus coeruleus are early features of progressive supranuclear palsy (PSP). This pathology is proposed to contribute to the clinical expression of disease, including the PSP Richardson's syndrome. Read More

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February 2020

Parkinsonism in frontotemporal dementias.

Authors:
James B Rowe

Int Rev Neurobiol 2019 21;149:249-275. Epub 2019 Nov 21.

Cambridge University Centre for Frontotemporal Dementia and Cambridge University Centre for Parkinson-plus, Cambridge University, Cambridge, United Kingdom.

Frontotemporal dementia is a clinically and pathologically heterogeneous group of neurodegenerative disorders, with progressive impairment of behavior and language. They can be closely related to amyotrophic lateral sclerosis, clinically and through shared genetics and similar pathology. Approximately 40% of people with frontotemporal dementia report a family history of dementia, motor neuron disease or parkinsonism, and half of these familial cases are attributed to mutations in three genes (C9orf72, MAPT and PGRN). Read More

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Urological function and dysfunction in aging: Diagnosis and treatment.

Handb Clin Neurol 2019 ;167:495-509

Center for Health in Aging, Emory University School of Medicine, Atlanta, GA, United States.

Urinary symptoms worsen further the quality of life of persons already burdened by neurologic disease. Urinary symptoms frequently occur in the setting of neurologic diseases such as Parkinson disease and Parkinson-plus syndromes, multiple sclerosis, and stroke. Urinary incontinence is associated with increased caregiver burden and enhances the risk of institutionalization among those living with dementia. Read More

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Recognizing and treating atypical Parkinson disorders.

Handb Clin Neurol 2019 ;167:301-320

Department of Neurology, University of Florida College of Medicine, Gainesville, FL, United States.

Though less common than Parkinson's disease (PD), the atypical Parkinson disorders such as such as dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration are increasingly recognized and important to distinguish from PD. Atypical or "Parkinson-plus" disorders are multisystem disorders and generally progress more rapidly and respond poorly to current therapies compared to PD. Recent advances in our understanding of the pathophysiology of these disorders, however, have generated new interest in the development of novel diagnostics and disease-modifying therapeutics aimed at identifying and treating these disorders. Read More

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Dysphagia in Progressive Supranuclear Palsy.

Dysphagia 2020 08 1;35(4):667-676. Epub 2019 Nov 1.

Department of Neurology, Mayo Clinic, 200 1st Street S.W., Rochester, MN, 55905, USA.

Progressive supranuclear palsy (PSP) is the most common Parkinson-Plus syndrome and is associated with early onset of dysphagia relative to Parkinson Disease. The current study contributes to the growing understanding of swallowing dysfunction in PSP by describing oropharyngeal swallowing characteristics in a large prospective cohort of participants with PSP employing a nationally standardized videofluoroscopy protocol and a disease severity scale developed expressly for PSP. Participants were 51 adults diagnosed with PSP. Read More

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Survival, effect measures, and impact numbers after dementia diagnosis: a matched cohort study.

Clin Epidemiol 2019 16;11:525-542. Epub 2019 Jul 16.

Research Group on Ageing, Disability and Health, Girona Biomedical Research Institute (IDIBGI), Catalonia, Spain.

Background: Knowledge on survival after diagnosis is important for all stakeholders. We aimed to estimate the survival and life expectancy after a dementia diagnosis, and to quantify the impact of dementia subtypes on mortality.

Methods: Retrospective matched cohort study using a linkage between a dementia-specific registry and two primary care electronic medical records databases. Read More

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