1,764 results match your criteria Parkinson Disease in Young Adults


Movement disorders and neuropathies: overlaps and mimics in clinical practice.

J Neurol 2022 Jun 3. Epub 2022 Jun 3.

Clinical Neurology Unit, "Azienda Socio-Sanitaria Territoriale Santi Paolo E Carlo" and Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142, Milan, Italy.

Movement disorders as well as peripheral neuropathies are extremely frequent in the general population; therefore, it is not uncommon to encounter patients with both these conditions. Often, the coexistence is coincidental, due to the high incidence of common causes of peripheral neuropathy, such as diabetes and other age-related disorders, as well as of Parkinson disease (PD), which has a typical late onset. Nonetheless, there is broad evidence that PD patients may commonly develop a sensory and/or autonomic polyneuropathy, triggered by intrinsic and/or extrinsic mechanisms. Read More

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Genome-Wide mRNA Expression Analysis of Acute Psychological Stress Responses.

MEDICC Rev 2022 May 16;24(2):35-42. Epub 2022 May 16.

School of Medicine, University of Virginia, USA.

Introduction: Most previous studies have examined the effects of acute psychological stress in humans based on select gene panels. The genomic approach may help identify novel genes that underline biological mechanisms of acute psychological stress responses.

Objective: This exploratory study aimed to investigate genome-wide transcriptional activity changes in response to acute psychological stress. Read More

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Imposed load versus voluntary investment: Executive control and attention management in dual-task performance.

Acta Psychol (Amst) 2022 Jul 11;227:103591. Epub 2022 May 11.

Faculty of Industrial Engineering and Management Technion, Israel Institute of Technology, Technion city, Haifa 32000, Israel.

Dual task performance is one of the most frequently used paradigm in the evaluation of coping with concurrent task demands. The Breakfast Task experimented in this paper, was originally developed as a general indicator of coping ability with high demand executive control and attention management requirements. It is a computer-based simulation, in which the performer is required to cook several food items while concurrently setting table for guests. Read More

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Tolerability and feasibility of at-home remotely supervised transcranial direct current stimulation (RS-tDCS): Single-center evidence from 6,779 sessions.

Brain Stimul 2022 May-Jun;15(3):707-716. Epub 2022 Apr 22.

Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA. Electronic address:

Introduction: The ability to deploy transcranial direct current stimulation (tDCS) at home is a key usability advantage to support scaling for pivotal clinical trials. We have established a home-based tDCS protocol for use in clinical trials termed remotely supervised (RS)-tDCS.

Objective: To report the tolerability and feasibility of tDCS sessions completed to date using RS-tDCS in clinical trials. Read More

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Neurofilament Light Protein as a Potential Blood Biomarker for Huntington's Disease in Children.

Mov Disord 2022 Apr 18. Epub 2022 Apr 18.

Huntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

Background: Juvenile-onset Huntington's disease (JOHD) is a rare and particularly devastating form of Huntington's disease (HD) for which clinical diagnosis is challenging and robust outcome measures are lacking. Neurofilament light protein (NfL) in plasma has emerged as a prognostic biomarker for adult-onset HD.

Methods: We performed a retrospective analysis of samples and data collected between 2009 and 2020 from the Kids-HD and Kids-JHD studies. Read More

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Investigating the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinson's Disease.

Front Neurol 2022 24;13:793693. Epub 2022 Mar 24.

Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.

Cerebellar-thalamic connections play a central role in deep brain stimulation-based treatment of tremor syndromes. Here, we used diffusion Magnetic Resonance Imaging (MRI) tractography to delineate the main cerebellar peduncles as well as two main white matter tracts that connect the cerebellum with the thalamus, the dentato-rubro-thalamic tract (DRTT) and the subthalamo-ponto-cerebellar tract (SPCT). We first developed a reconstruction protocol in young healthy adults with high-resolution diffusion imaging data and then demonstrate feasibility of transferring this protocol to clinical studies using standard diffusion MRI data from a cohort of patients with Parkinson's disease (PD) and their matched healthy controls. Read More

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The effects of Parkinson's disease, music training, and dance training on beat perception and production abilities.

PLoS One 2022 8;17(3):e0264587. Epub 2022 Mar 8.

Department of Psychology, Western University, London, Ontario, Canada.

Humans naturally perceive and move to a musical beat, entraining body movements to auditory rhythms through clapping, tapping, and dancing. Yet the accuracy of this seemingly effortless behavior varies widely across individuals. Beat perception and production abilities can be improved by experience, such as music and dance training, and impaired by progressive neurological changes, such as in Parkinson's disease. Read More

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Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease.

Sci Rep 2022 02 28;12(1):3289. Epub 2022 Feb 28.

Department of Psychology and Neuroscience, Temple University, Weiss Hall, 1701 N. 13th St, Philadelphia, PA, 19112, USA.

In Parkinson's disease (PD), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (SN), while leaving the ventral tegmental area (VTA) relatively spared in early phases of the disease. Although the SN and VTA are known to be functionally dissociable in healthy adults, it remains unclear how this dissociation is altered in PD. To examine this issue, we performed a whole-brain analysis to compare functional connectivity in PD to healthy adults using resting-state functional magnetic resonance imaging (rs-fMRI) data compiled from three independent datasets. Read More

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February 2022

Comparing adaptive fractal and detrended fluctuation analyses of stride time variability: Tests of equivalence.

Gait Posture 2022 05 17;94:9-14. Epub 2022 Feb 17.

Department of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN, USA.

Background: Fractal analyses quantify self-similarities in stride-to-stride fluctuations over different time scales. Fractal exponents can be measured with adaptive fractal analysis (AFA) or detrended fluctuation analysis (DFA), though measurements obtained with the algorithms have not been directly compared.

Research Question: Are stride time fractal exponents measured with AFA and DFA algorithms equivalent?

Methods: Data from 50 participants with Parkinson's Disease (n = 15), age-similar healthy adults (n = 15) and healthy young adults (n = 20) were analyzed in this cross-sectional, observational study. Read More

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Analysis of mRNA and Protein Levels of , and Genes in Post-Mortem Brain of Schizophrenia, Parkinson's and Alzheimer's Disease Patients.

Int J Mol Sci 2022 Jan 28;23(3). Epub 2022 Jan 28.

Laboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.

Schizophrenia (SCZ) is a mental illness characterized by aberrant synaptic plasticity and connectivity. A large bulk of evidence suggests genetic and functional links between postsynaptic abnormalities and SCZ. Here, we performed quantitative PCR and Western blotting analysis in the dorsolateral prefrontal cortex (DLPFC) and hippocampus of SCZ patients to investigate the mRNA and protein expression of three key spine shapers: the actin-binding protein cyclase-associated protein 2 (), the sheddase a disintegrin and metalloproteinase 10 (), and the synapse-associated protein 97 (). Read More

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January 2022

Associations of Young Adult Intelligence, Education, Height, and Body Mass Index with Subsequent Risk of Parkinson's Disease and Survival: A Danish Cohort Study.

J Parkinsons Dis 2022 ;12(3):1035-1043

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospitals, Frederiksberg, Denmark.

Background: The underlying disease mechanisms of Parkinson's disease (PD) are still unknown and knowledge about risk and prognostic factors is sparse.

Objective: To examine the association between intelligence, education, body height, and body mass index (BMI) in young adulthood and risk of PD and subsequent survival.

Methods: In total, 656,751 men born 1939-1959 with information from conscription examinations around age 19 years were followed for PD and mortality from 1977-2018 in Danish registries. Read More

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January 2022

Age-related differences in the quantitative analysis of the finger tapping task.

Technol Health Care 2022 ;30(S1):115-122

BK21 Plus Research Institute of Biomedical Engineering, Konkuk University, Chungju, Korea.

Background: Quantitative measures of the finger tapping task is important for objective assessment of bradykinesia. However, age-related changes in quantitative measures are still unclear.

Objective: The aim of this study was to quantitatively investigate age-related group differences in finger tapping performance. Read More

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The netrin-1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson's disease.

J Neurochem 2022 05 14;161(3):254-265. Epub 2022 Feb 14.

Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Mechanisms that determine the survival of midbrain dopaminergic (mDA) neurons in the adult central nervous system (CNS) are not fully understood. Netrins are a family of secreted proteins that are essential for normal neural development. In the mature CNS, mDA neurons express particularly high levels of netrin-1 and its receptor Deleted in Colorectal Cancer (DCC). Read More

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The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease.

Int Arch Otorhinolaryngol 2022 Jan 29;26(1):e158-e166. Epub 2021 Mar 29.

Clinica Ouvire, Campinas, SP, Brazil.

 Parkinson disease (PD) is a degenerative and progressive neurological disorder characterized by resting tremor, stiffness, bradykinesia, and postural instability. Despite the motor symptoms, PD patients also consistently show cognitive impairment or executive dysfunction. The auditory event-related potential P300 has been described as the best indicator of mental function, being highly dependent on cognitive skills, including attention and discrimination. Read More

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January 2022

Redesigning therapies for pantothenate kinase-associated neurodegeneration.

J Biol Chem 2022 03 15;298(3):101577. Epub 2022 Jan 15.

Section of Infectious Diseases, Department of Internal Medicine and Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address:

Pantothenate kinase-associated neurodegeneration (PKAN) is an incurable rare genetic disorder of children and young adults caused by mutations in the PANK2 gene, which encodes an enzyme critical for the biosynthesis of coenzyme A. Although PKAN affects only a small number of patients, it shares several hallmarks of more common neurodegenerative diseases of older adults such as Alzheimer's disease and Parkinson's disease. Advances in etiological understanding and treatment of PKAN could therefore have implications for our understanding of more common diseases and may shed new lights on the physiological importance of coenzyme A, a cofactor critical for the operation of various cellular metabolic processes. Read More

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Heterogeneous digital biomarker integration out-performs patient self-reports in predicting Parkinson's disease.

Commun Biol 2022 01 17;5(1):58. Epub 2022 Jan 17.

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Parkinson's disease (PD) is one of the first diseases where digital biomarkers demonstrated excellent performance in differentiating disease from healthy individuals. However, no study has systematically compared and leveraged multiple types of digital biomarkers to predict PD. Particularly, machine learning works on the fine-motor skills of PD are limited. Read More

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January 2022

Effects of vitamin D (VD3) supplementation on the brain mitochondrial function of male rats, in the 6-OHDA-induced model of Parkinson's disease.

Neurochem Int 2022 03 10;154:105280. Epub 2022 Jan 10.

Faculty of Medicine of the Federal University of Ceará (UFC), Brazil. Electronic address:

Mitochondria dysfunction is an important factor involved in PD pathogenesis. We reported neuroprotective actions of vitamin D (VD3) on a PD model, and now we investigated the VD3 effects on the brain mitochondrial function. We focused on oxygen consumption, respiratory control ratio (RCR), ADP/O ratio, mitochondria swelling, HO production, and SOD activity. Read More

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A Frequent Observation of Wolff-Parkinson-White Syndrome and Fasciculoventricular Pathways in Patients With Danon Disease.

Circ J 2022 01 23;86(2):309-318. Epub 2021 Dec 23.

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Provincial People's Hospital.

Background: Danon disease is typically associated with cardiomyopathy and ventricular pre-excitation. The study aimed to characterize the clinical profile of Danon disease, analyze electrocardiographic (ECG) and electrophysiologic features, and investigate their association with Wolff-Parkinson-White (WPW) syndrome and fasciculoventricular pathways (FVPs).Methods and Results:Clinical course, family history, ECG and electrophysiological data were collected from 16 patients with Danon disease. Read More

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January 2022

Adopting a multidisciplinary telemedicine intervention for fall prevention in Parkinson's disease. Protocol for a longitudinal, randomized clinical trial.

PLoS One 2021 21;16(12):e0260889. Epub 2021 Dec 21.

Hospital Universitario Burgos, Burgos, Spain.

Background: Approximately 40-70% of people with Parkinson's disease (PD) fall each year, causing decreased activity levels and quality of life. Current fall-prevention strategies include the use of pharmacological and non-pharmacological therapies. To increase the accessibility of this vulnerable population, we developed a multidisciplinary telemedicine program using an Information and Communication Technology (ICT) platform. Read More

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January 2022

Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson's Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial.

J Parkinsons Dis 2022 ;12(2):557-570

Sanofi, Cambridge, MA, USA.

Background: Glucocerebrosidase gene (GBA) mutations influence risk and prognosis of Parkinson's disease (PD), possibly through accumulation of glycosphingolipids, including glucosylceramide (GL-1). Venglustat is a novel, brain penetrant glucosylceramide synthase inhibitor.

Objective: Evaluate venglustat pharmacology, safety, and tolerability in patients with PD and GBA mutations (GBA-PD). Read More

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January 2022

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.

Hum Genet 2022 Jan 10;141(1):147-173. Epub 2021 Dec 10.

Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. Read More

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January 2022

Strategic alterations of posture are delayed in Parkinson's disease patients during deep brain stimulation.

Sci Rep 2021 12 7;11(1):23550. Epub 2021 Dec 7.

Department of Clinical Sciences, Lund University, 221 85, Lund, Sweden.

Parkinson's disease (PD) is characterized by rigidity, akinesia, postural instability and tremor. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces tremor but the effects on postural instability are inconsistent. Another component of postural control is the postural strategy, traditionally referred to as the ankle or hip strategy, which is determined by the coupling between the joint motions of the body. Read More

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December 2021

Can People with Parkinson's Disease Self-Trigger Gait Initiation? A Comparison of Cueing Strategies.

J Parkinsons Dis 2022 ;12(2):607-619

Department of Neurology, University of Minnesota, Minneapolis, MN, USA.

Background: An external cue can markedly improve gait initiation in people with Parkinson's disease (PD) and is often used to overcome freezing of gait (FOG). It is unknown if the effects of external cueing are comparable if the imperative stimulus is triggered by the person receiving the cue (self-triggered) or an external source.

Objective: Two experiments were conducted to compare the effects of self- versus externally triggered cueing on anticipatory postural adjustments (APAs) during gait initiation in people with PD. Read More

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Impact of α-synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology.

Brain Pathol 2022 03 21;32(2):e13036. Epub 2021 Nov 21.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Misfolded α-synuclein spreads along anatomically connected areas through the brain, prompting progressive neurodegeneration of the nigrostriatal pathway in Parkinson's disease. To investigate the impact of early stage seeding and spreading of misfolded α-synuclein along with the nigrostriatal pathway, we studied the pathophysiologic effect induced by a single acute α-synuclein preformed fibrils (PFFs) inoculation into the midbrain. Further, to model the progressive vulnerability that characterizes the dopamine (DA) neuron life span, we used two cohorts of mice with different ages: 2-month-old (young) and 5-month-old (adult) mice. Read More

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Comparisons of vesicular monoamine transporter type 2 signals in Parkinson's disease and parkinsonism secondary to carbon monoxide poisoning.

Neurotoxicology 2022 01 10;88:178-186. Epub 2021 Nov 10.

Department of Neurology, Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Parkinson's disease (PD) and carbon monoxide (CO) poisoning demonstrate parkinsonian features related to presynaptic dopaminergic deficits. However, their clinical features and treatment responses are different, indicating other roles of neurotransmitters in symptomatic modulation. In this study, we used F-FP-(+)-DTBZ PET to explore vesicular monoamine transporter type 2 (VMAT2) distributions in 31 patients with PD, 39 patients with CO poisoning and parkinsonian features (n = 39), and 24 age-matched controls. Read More

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January 2022

Anticipating social incentives recruits alpha-beta oscillations in the human substantia nigra and invigorates behavior across the life span.

Neuroimage 2021 12 31;245:118696. Epub 2021 Oct 31.

Department of Psychology, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany; Center of Brain, Behavior and Metabolism, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany. Electronic address:

Anticipating social and non-social incentives recruits shared brain structures and promotes behavior. However, little is known about possible age-related behavioral changes, and how the human substantia nigra (SN) signals positive and negative social information. Therefore, we recorded intracranial electroencephalography (iEEG) from the SN of Parkinson's Disease (PD) patients (n = 12, intraoperative, OFF medication) in combination with a social incentive delay task including photos of neutral, positive or negative human gestures and mimics as feedback. Read More

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December 2021

Wearable Inertial Gait Algorithms: Impact of Wear Location and Environment in Healthy and Parkinson's Populations.

Sensors (Basel) 2021 Sep 28;21(19). Epub 2021 Sep 28.

Department of Computer and Information Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.

Wearable inertial measurement units (IMUs) are used in gait analysis due to their discrete wearable attachment and long data recording possibilities within indoor and outdoor environments. Previously, lower back and shin/shank-based IMU algorithms detecting initial and final contact events (ICs-FCs) were developed and validated on a limited number of healthy young adults (YA), reporting that both IMU wear locations are suitable to use during indoor and outdoor gait analysis. However, the impact of age (e. Read More

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September 2021

Juvenile-Onset Huntington Disease Pathophysiology and Neurodevelopment: A Review.

Mov Disord 2022 01 12;37(1):16-24. Epub 2021 Oct 12.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

Huntington disease is an autosomal dominant inherited brain disorder that typically becomes manifest in adulthood. Juvenile-onset Huntington disease refers to approximately 5% of patients with symptom onset before the age of 21 years. The causal factor is a pathologically expanded CAG repeat in the Huntingtin gene. Read More

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January 2022

Parkinsonism and motor neuron disorders: Lessons from Western Pacific ALS/PDC.

Authors:
Peter S Spencer

J Neurol Sci 2022 Feb 2;433:120021. Epub 2021 Oct 2.

Department of Neurology, School of Medicine, Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon, USA. Electronic address:

Recognized worldwide as an unusual "overlap" syndrome, Parkinsonism and motor neuron disease, with or without dementia, is best exemplified by the former high-incidence clusters of Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex (ALS/PDC) in Guam, USA, in the Kii Peninsula of Honshu Island, Japan, and in Papua, Indonesia, on the western side of New Guinea. Western Pacific ALS/PDC is a disappearing neurodegenerative disorder with multiple and sometime overlapping phenotypes (ALS, atypical parkinsonism, dementia) that appear to constitute a single disease of environmental origin, in particular from exposure to genotoxins/neurotoxins in seed of cycad plants (Cycas spp.) formerly used as a traditional source of food (Guam) and/or medicine (Guam, Kii-Japan, Papua-Indonesia). Read More

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February 2022