1,400 results match your criteria Parkinson Disease in Young Adults


DRD2 Genotype-Based Variants Modulates D2 Receptor Distribution in Ventral Striatum.

Mol Neurobiol 2019 Mar 8. Epub 2019 Mar 8.

Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

Dopaminergic signaling within the striatum is crucial for motor planning and mental function. Neurons within the striatum contain two dopamine D2 receptor isoforms-D2 long and D2 short. The amount of expression for these receptor isoforms is affected by the genotype within two single nucleotide polymorphisms (SNPs), rs2283265 and rs1076560 (both are in high linkage disequilibrium; C > A), found in the DRD2 gene. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12035-019-1543-0
Publisher Site
http://dx.doi.org/10.1007/s12035-019-1543-0DOI Listing
March 2019
10 Reads

22q11.2 Deletion Syndrome-Associated Parkinson's Disease.

Mov Disord Clin Pract 2019 Jan 9;6(1):11-16. Epub 2018 Nov 9.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease Research Toronto Western Hospital and University of Toronto Toronto Ontario Canada.

Background: 22q11.2 deletion syndrome (22q11.2DS) is a multisystem condition associated with an increased risk of early-onset Parkinson's disease (PD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mdc3.12687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335527PMC
January 2019
2 Reads

Neural Substrates of Cognitive Motor Interference During Walking; Peripheral and Central Mechanisms.

Front Hum Neurosci 2018 9;12:536. Epub 2019 Jan 9.

Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, United Kingdom.

Current gait control models suggest that independent locomotion depends on central and peripheral mechanisms. However, less information is available on the integration of these mechanisms for adaptive walking. In this cross-sectional study, we investigated gait control mechanisms in people with Parkinson's disease (PD) and healthy older (HO) adults: at self-selected walking speed (SSWS) and at fast walking speed (FWS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnhum.2018.00536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333849PMC
January 2019
1 Read

Beat perception ability and instructions to synchronize influence gait when walking to music-based auditory cues.

Gait Posture 2019 02 2;68:555-561. Epub 2019 Jan 2.

Brain & Mind Institute, University of Western Ontario, Canada; Department of Psychology, University of Western Ontario, Canada. Electronic address:

Synchronizing gait to music-based auditory cues (rhythmic auditory stimulation) is a strategy used to manage gait impairments in a variety of neurological conditions, including Parkinson's disease. However, knowledge of how to individually optimize music-based cues is limited. The purpose of this study was to investigate how instructions to synchronize with auditory cues influences gait outcomes among healthy young adults with either good or poor beat perception ability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gaitpost.2018.12.038DOI Listing
February 2019
4 Reads

Changes in event-related potentials during dual task walking in aging and Parkinson's disease.

Clin Neurophysiol 2019 Feb 8;130(2):224-230. Epub 2018 Dec 8.

Laboratory of Early Markers of Neurodegeneration, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Neurological Institute, Tel Aviv Medical Center, Tel-Aviv, Israel; Department of Neurology, Sackler School of Medicine, Tel Aviv University, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: To investigate EEG changes during an auditory odd-ball task while walking (dual-task) in young adults, older adults, and patients with Parkinson's disease.

Methods: 11 young adults, 10 older adults, and 10 patients with Parkinson's disease (PD) performed an auditory oddball task during standing and walking on a treadmill, while wearing a wireless EEG cap. The amplitude and latency of P300 were compared between groups and within conditions using linear mix model analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2018.11.019DOI Listing
February 2019
4 Reads

Parkinson's disease versus ageing: different postural responses to soleus muscle vibration.

Gait Posture 2018 09 19;65:169-175. Epub 2018 Jul 19.

Institute of Normal and Pathological Physiology, Centre of Experimental Medicine Slovak Academy of Sciences, Sienkiewiczova 1, 813 71, Bratislava, Slovak Republic. Electronic address:

Background: Impairments of postural stability occur with increasing age and in neurodegenerative diseases like the Parkinson's disease (PD). While changes in balance have been described in many studies under steady-state conditions, less is known about the dynamic changes in balance following sudden transition to different sensory inputs.

Research Question: The aim was to clarify different effects of age and Parkinson's disease on dynamic postural responses immediately after lower leg muscle stimulation offset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gaitpost.2018.07.162DOI Listing
September 2018
4 Reads

Quantifying Dynamic Balance in Young, Elderly and Parkinson's Individuals: A Systematic Review.

Front Aging Neurosci 2018 22;10:387. Epub 2018 Nov 22.

School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.

Falling is one of the primary concerns for people with Parkinson's Disease and occurs predominately during dynamic movements, such as walking. Several methods have been proposed to quantify dynamic balance and to assess fall risk. However, no consensus has been reached concerning which method is most appropriate for examining walking balance during unperturbed and perturbed conditions, particularly in Parkinson's Disease individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnagi.2018.00387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262057PMC
November 2018
3 Reads

Non-motor Symptoms in Patients with Parkinson's Disease: A Cross-sectional Survey.

Cureus 2018 Oct 4;10(10):e3412. Epub 2018 Oct 4.

Neurology, Shifa International Hospital, Islamabad, PAK.

Background In multiple studies around the globe, non-motor symptoms (NMS) have been identified as a source of immense disability in patients with Parkinson's disease (PD). However, there is a scarcity of data from Asia. This is the first study of the Pakistani population to assess the impact of NMS in PD on patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281445PMC
October 2018
12 Reads

Kinematic and Kinetic Patterns Related to Free-Walking in Parkinson's Disease.

Sensors (Basel) 2018 Dec 1;18(12). Epub 2018 Dec 1.

Neuroimaging Laboratory, Division of Neurosciences, CIMA University of Navarra, Applied Medical Research, 31008 Pamplona, Spain.

The aim of this study is to compare the properties of free-walking at a natural pace between mild Parkinson's disease (PD) patients during the ON-clinical status and two control groups. In-shoe pressure-sensitive insoles were used to quantify the temporal and force characteristics of a 5-min free-walking in 11 PD patients, in 16 young healthy controls, and in 12 age-matched healthy controls. Inferential statistics analyses were performed on the kinematic and kinetic parameters to compare groups' performances, whereas feature selection analyses and automatic classification were used to identify the signature of parkinsonian gait and to assess the performance of group classification, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s18124224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308417PMC
December 2018
2 Reads
2.245 Impact Factor

Anti-saccades predict cognitive functions in older adults and patients with Parkinson's disease.

PLoS One 2018 28;13(11):e0207589. Epub 2018 Nov 28.

School of Optometry, University of Montreal, Montreal, Quebec, Canada.

A major component of cognitive control is the ability to act flexibly in the environment by either behaving automatically or inhibiting an automatic behaviour. The interleaved pro/anti-saccade task measures cognitive control because the task relies on one's abilities to switch flexibly between pro and anti-saccades, and inhibit automatic saccades during anti-saccade trials. Decline in cognitive control occurs during aging or neurological illnesses such as Parkinson's disease (PD), and indicates decline in other cognitive abilities, such as memory. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207589PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261587PMC

Classification of Gait Patterns in Patients with Neurodegenerative Disease Using Adaptive Neuro-Fuzzy Inference System.

Comput Math Methods Med 2018 30;2018:9831252. Epub 2018 Sep 30.

Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, China.

A common feature that is typical of the patients with neurodegenerative (ND) disease is the impairment of motor function, which can interrupt the pathway from cerebrum to the muscle and thus cause movement disorders. For patients with amyotrophic lateral sclerosis disease (ALS), the impairment is caused by the loss of motor neurons. While for patients with Parkinson's disease (PD) and Huntington's disease (HD), it is related to the basal ganglia dysfunction. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/cmmm/2018/9831252/
Publisher Site
http://dx.doi.org/10.1155/2018/9831252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186329PMC
February 2019
21 Reads

Visual detection of affordances for aperture negotiation in people with Parkinson disease.

Neuropsychologia 2018 11 18;120:59-64. Epub 2018 Oct 18.

First Physical Therapy, United States.

Background: An essential requirement for the guidance of action in cluttered environments is that people can accurately perceive what actions are afforded by particular surroundings given the person's action capabilities. Research has shown that healthy young individuals turn their shoulders when walking through a doorway when the aperture is less than a certain percentage of their shoulder width and that they are able to detect this critical width with visual inspection. These findings imply that movements are constrained by perception of the environment in body-scaled unit. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00283932183071
Publisher Site
http://dx.doi.org/10.1016/j.neuropsychologia.2018.10.010DOI Listing
November 2018
18 Reads

[Prescribing patterns of antiparkinson drugs in a group of Colombian patients, 2015].

Biomedica 2018 09 1;38(3):417-426. Epub 2018 Sep 1.

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma, S.A., Pereira, Colombia.

Introduction: Parkinson's disease, whose prevalence in Colombia is 4.7 per 1,000 inhabitants, is a public health problem and a therapeutic challenge for health professionals.

Objective: To determine the prescribing patterns of antiparkinson drugs and the variables associated with its use in a population from Colombia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7705/biomedica.v38i4.3781DOI Listing
September 2018
1 Read

"You can tell by the way I use my walk." Predicting the presence of cognitive load with gait measurements.

Biomed Eng Online 2018 Sep 12;17(1):122. Epub 2018 Sep 12.

Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.

Background: There is considerable evidence that a person's gait is affected by cognitive load. Research in this field has implications for understanding the relationship between motor control and neurological conditions in aging and clinical populations. Accordingly, this pilot study evaluates the cognitive load based on gait accelerometry measurements of the walking patterns of ten healthy individuals (18-35 years old). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12938-018-0555-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134780PMC
September 2018
1 Read

A Novel SYNJ1 Mutation in a Tunisian Family with Juvenile Parkinson's Disease Associated with Epilepsy.

J Mol Neurosci 2018 Oct 5;66(2):273-278. Epub 2018 Sep 5.

Laboratoire de Recherche en Neurogénétique, Maladie de Parkinson et Maladies Cérébro-Vasculaires (LR-12-SP-19), Habib Bourguiba University Hospital, 3029, Sfax, Tunisia.

Mutations in SYNJ1 gene have been described in few families with juvenile atypical Parkinson disease (PD). This gene encodes for "Synaptojanin 1," an enzyme playing a major role in the phosphorylation and the recycling of synaptic vesicles. In this study, we report two siblings, from a consanguineous Tunisian family, presenting juvenile PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-018-1167-2DOI Listing
October 2018
15 Reads

The relationship between four GWAS-identified loci in Alzheimer's disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophy.

Neurosci Lett 2018 11 22;686:205-210. Epub 2018 Aug 22.

Department of Neurology and West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Background: A number of genetic variants have previously been identified and associated with the risk of Alzheimer's disease (AD), including rs10838725 in CELF1, rs28834970 in PTK2B, rs17125944 in FERMT2, and rs10410544 in SIRT2 based on genome-wide association studies. Considering the overlap between the clinical manifestation and pathological characteristics of AD and Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), we conducted a large sample study to investigate the associations between these variants and these three common neurodegenerative diseases in a Chinese population.

Methods: A total of 2449 patients, including 1219 PD, 870 sporadic ALS, and 360 MSA, and 821 healthy controls were examined for this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2018.08.024DOI Listing
November 2018
3 Reads

Mitochondrial DNA mutation "m.3243A>G"-Heterogeneous clinical picture for cardiologists ("m.3243A>G": A phenotypic chameleon).

Congenit Heart Dis 2018 Sep 21;13(5):671-677. Epub 2018 Aug 21.

Department of Child and Adolescent Health, Pediatrics I/III, Medical University of Innsbruck, Innsbruck, Austria.

Objective: In general, a mitochondrial disorder is diagnosed on the basis of symptom combinations and confirmed by genetic findings. However, patients carrying the m.3243A>G mutation in the mitochondrial tRNA leucine 1 (MT-TL1) do not always meet all the proposed criteria for the most frequently encountered mitochondrial syndrome "MELAS," an acronym for Mitochondrial Encephalomyopathy, Lactic Acidosis, and at least one Stroke-like episode. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/chd.12634
Publisher Site
http://dx.doi.org/10.1111/chd.12634DOI Listing
September 2018
10 Reads

Is transcranial sonography useful for diagnosing Parkinson's disease in clinical practice?

Arq Neuropsiquiatr 2018 Jul;76(7):459-466

Universidade de Brasília, Faculdade de Medicina, Brasília DF, Brasil.

Objective: Transcranial sonography (TCS) is an emerging ancillary examination for diagnosing Parkinson's disease (PD).

Objective: To evaluate TCS features in patients with PD and its mimics, and establish their accuracy in predicting the final clinical diagnosis after follow-up.

Methods: We retrospectively studied 85 patients with an initial clinical suspicion of PD, atypical parkinsonism or essential tremor, all of whom underwent TCS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0004-282X20180067DOI Listing
July 2018
6 Reads

Novel biomarker for neurodegenerative diseases- motor neuron disease (MND), cerebellar ataxia (CA) and Parkinson's disease (PD).

Clin Chim Acta 2018 Oct 10;485:258-261. Epub 2018 Jul 10.

Department of Biochemistry, KGMU, Lucknow 226003, UP, India.

Oxygen is the most mandatory component of living organism and it may at times produce highly reactive species, the free radicals, which are destructive to normal living tissues. Degenerative diseases of central nervous system (CNS) are quite common, contributing significantly to morbidity as well as mortality %. In neurodegenerative diseases such as motor neuron disease (MND), Cerebellar Ataxia (CA) and Parkinson's disease (PD), there is no direct evidence for involvement of metals and free radicals in the etiology but circumstantial evidence provides a hypothesis that alteration in metals and free radicals contribute to the pathogenesis of neurodegeneration in these disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2018.07.021DOI Listing
October 2018
13 Reads
2.824 Impact Factor

Categorization system-switching deficits in typical aging and Parkinson's disease.

Neuropsychology 2018 Sep 28;32(6):724-734. Epub 2018 Jun 28.

Department of Psychological Sciences, Purdue University.

Objective: Numerous studies documenting cognitive deficits in Parkinson's disease (PD) revealed impairment in a variety of tasks related to memory, learning, and attention. One ubiquitous task that has not received much attention, is categorization system-switching. Categorization system-switching is a form of task-switching requiring participants to switch between different categorization systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1037/neu0000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126963PMC
September 2018
1 Read

GCH1 mutations in dopa-responsive dystonia and Parkinson's disease.

J Neurol 2018 Aug 14;265(8):1860-1870. Epub 2018 Jun 14.

Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Guanosine triphosphate cyclohydrolase I (GCH1) mutations are associated with increased risk for dopa-responsive dystonia (DRD) and Parkinson's disease (PD). Herein, we investigated the frequency of GCH1 mutations and clinical symptoms in patients with clinically diagnosed PD and DRD. We used the Sanger method to screen entire exons in 268 patients with PD and 26 patients with DRD, with the examinations of brain magnetic resonance imaging scans, striatal dopamine transporter scans, and [I] metaiodobenzylguanidine (MIBG) myocardiac scintigraphy scans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-018-8930-8DOI Listing
August 2018
18 Reads

Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway.

Mol Cell Proteomics 2018 09 18;17(9):1778-1787. Epub 2018 Jun 18.

From the ‡Department of Molecular and Translational Medicine, Center for Biomedical Mass Spectrometry, Boston University Medical Campus, Boston, Massachusetts;

Parkinson's disease (PD) is a neurological disorder characterized by the progressive loss of functional dopaminergic neurons in the nigrostriatal pathway in the brain. Although current treatments provide only symptomatic relief, gene therapy has the potential to slow or halt the degeneration of nigrostriatal dopamine neurons in PD patients. Adeno-associated viruses (AAV) are vectors of choice in gene therapy because of their well-characterized safety and efficacy profiles; however, although gene therapy has been successful in preclinical models of the disease, clinical trials in humans have failed to demonstrate efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.RA118.000680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126385PMC
September 2018
21 Reads

Long-Term Effect of Modified Incision to Prevent Related Complications in Deep Brain Stimulation.

World Neurosurg 2018 Sep 7;117:280-283. Epub 2018 Jun 7.

Department of Neurosurgery, Tsinghua University Yuquan Hospital, Shijingshan District, Beijing, China. Electronic address:

Background: Skin complications are a frequent type of complication of deep brain stimulation (DBS) neurosurgical procedure and are always observed in the postauricular area, scalp area, and implantable pulse generator pocket. Modifications to the surgical techniques for DBS have been proposed as therapeutic options. To prevent skin complications, we modified the surgical incisions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2018.05.224DOI Listing
September 2018
14 Reads

Age affects reinforcement learning through dopamine-based learning imbalance and high decision noise-not through Parkinsonian mechanisms.

Neurobiol Aging 2018 08 19;68:102-113. Epub 2018 Apr 19.

Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, Newark, NJ, USA. Electronic address:

Probabilistic reinforcement learning declines in healthy cognitive aging. While some findings suggest impairments are especially conspicuous in learning from rewards, resembling deficits in Parkinson's disease, others also show impairments in learning from punishments. To reconcile these findings, we tested 252 adults from 3 age groups on a probabilistic reinforcement learning task, analyzed trial-by-trial performance with a Q-reinforcement learning model, and correlated both fitted model parameters and behavior to polymorphisms in dopamine-related genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993631PMC
August 2018
3 Reads

Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson's disease.

Neurol Sci 2018 Aug 12;39(8):1415-1421. Epub 2018 May 12.

Department of Biostatistics and Medical Informatics, Ordu University Medical Faculty, Ordu, Turkey.

Aim: In this study, the aim was to identify the incidence of sarcopenia and dynapenia according to disease stage among idiopathic Parkinson's disease (IPD) patients and collect data to illuminate precautions related to reducing the disease load.

Method: The study was completed with 166 patients divided by stage according to modified Hoehn and Yahr (HYR) criteria and 249 healthy volunteers aged from 18 to 39 and 68 to 75 years met the inclusion criteria. In our prospective and cross-sectional study, patients with IPD according to "UK Brain Bank" diagnostic criteria had the Unified Parkinson's Disease Rating Scale (UPDRS) and HYR scales applied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-018-3439-6DOI Listing
August 2018
7 Reads

Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2.

Neurology 2018 Jun 11;90(23):e2059-e2067. Epub 2018 May 11.

From The Dalglish Family 22q Clinic for Adults and Department of Psychiatry (E.B., A.M.F., A.S.B.), Toronto General Research Institute (A.S.B.), and Division of Cardiology, Department of Medicine (A.S.B.), University Health Network, Toronto, Canada; De Hartekamp Groep (E.B.), Centre for People with Intellectual Disability, Haarlem; Department of Nuclear Medicine (E.B., J.B.), Academic Medical Center, Amsterdam, the Netherlands; Clinical Genetics Research Program and Campbell Family Mental Health Research Institute (N.J.B., A.M.F., A.S.B.), Centre for Addiction and Mental Health, Toronto; Institute of Medical Science (N.J.B., M.M., A.E.L., A.S.B.), Division of Neurology, Department of Medicine (C.M., M.M., A.E.L.), and Department of Psychiatry (A.S.B.), University of Toronto; Deer Lodge Movement Disorders Centre (S.U.); Section of Neurology (S.U.), Division of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease Research (C.M., A.E.L.), Toronto Western Hospital and University of Toronto, Canada; Department of Molecular Neuroscience (K.Y.M., N.W.W.), UCL Institute of Neurology, London, UK; Department of Neurology (S.K.), Kansai Medical University, Osaka, Japan; Department of Neurology (M.J.B.), University of Virginia School of Medicine, Charlottesville; Medical Genetics Unit (P.P.), Perugia University Hospital, Italy; Department of Neurology (B.D.B.), University of Colorado Anschutz Medical Campus, Aurora; Neurology Section (B.D.B.), VA Eastern Colorado Health Care System, Denver; Cognitive & Movement Disorders Clinic and Hurvitz Brain Sciences Research Program (M.M.), Sunnybrook Health Sciences Centre, Toronto, Canada; Departments of Clinical Neurosciences (Movement Disorders) (B.D.) and Genetics (Neurogenetics) (K.N.), Timone University Hospital (AP-HM), Provence-Alpes-Côte d'Azur; Aix-Marseille University (B.D., K.N.), Marseille; Department of Genetics (Neurogenetics) (P.C., A.J.), Pitié-Salpêtrière University Hospital; Sorbonne University (P.C., A.J.), Paris; Department of Neurosciences (Movement Disorders) (E.M.), Lille University Hospital; Lille University (E.M.); Department of Neurology (Movement Disorders) (T.D.), Pierre Wertheimer University Hospital, Lyon; Marc Jeannerod Center for Cognitive Neurosciences (T.D.), Lyon-1 University; Department of Neurology (Movement Disorders) and Clinical Investigation Center (Clinical and Experimental Neurosciences) (O.C.), Poitiers University Hospital; Department of Neurology (Movement Disorders) (S.D.), Rennes University Hospital; Rennes-1 University (S.D.); Department of Clinical Neurosciences (Movement Disorders) (M.B.), Nice University Hospital, France; Department of Psychiatry (A.M.F.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Center for Human Genetics (E.V., A.S., A.V.), University Hospital Leuven; Department of Human Genetics (A.S.), KU Leuven, Belgium; Department of Neurology (A.P.), University of Munich, Germany; Scientific and Technological Coordination Unit of the ANLIS Directorate (C.P.), National Administration of Laboratories and Institutes of Health, Argentina; Department of Neurodegenerative Diseases (T.G.), Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.); Department of Neurology (K.C.), AZ Turnhout, Antwerp, Belgium; Neurology Unit and Stroke Center (F.B.), Hôpital Foch, Suresnes, France; Movement Disorder Division (K.M.), Johns Hopkins University, Baltimore, MD; and Psychological Medicine and Clinical Neurosciences (N.M.W.), MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff University, UK.

Objective: To delineate the natural history, diagnosis, and treatment response of Parkinson disease (PD) in individuals with 22q11.2 deletion syndrome (22q11.2DS), and to determine if these patients differ from those with idiopathic PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000005660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993183PMC
June 2018
10 Reads

Tubulin and Tau: Possible targets for diagnosis of Parkinson's and Alzheimer's diseases.

PLoS One 2018 9;13(5):e0196436. Epub 2018 May 9.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

Neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by progressive neuronal loss and pathological accumulation of some proteins. Developing new biomarkers for both diseases is highly important for the early diagnosis and possible development of neuro-protective strategies. Serum antibodies (AIAs) against neuronal proteins are potential biomarkers for AD and PD that may be formed in response to their release into systemic circulation after brain damage. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942772PMC
August 2018
8 Reads

Botulinum Neurotoxin Injection for the Treatment of Recurrent Temporomandibular Joint Dislocation with and without Neurogenic Muscular Hyperactivity.

Authors:
Kazuya Yoshida

Toxins (Basel) 2018 04 25;10(5). Epub 2018 Apr 25.

Department of Oral and Maxillofacial Surgery, National Hospital Organization, Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, Japan.

The aim of this study was to compare treatment outcomes following intramuscular injection of botulinum neurotoxin (BoNT) in patients with recurrent temporomandibular joint dislocation, with and without muscle hyperactivity due to neurological diseases. Thirty-two patients (19 women and 13 men, mean age: 62.3 years) with recurrent temporomandibular joint dislocation were divided into two groups: neurogenic (8 women and 12 men) and habitual (11 women and 1 man). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins10050174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983230PMC
April 2018
3 Reads

Outcomes of Ebstein's Anomaly Patients Treated with Tricuspid Valvuloplasty or Tricuspid Valve Replacement: Experience of a Single Center.

Chin Med J (Engl) 2018 May;131(9):1067-1074

Department of Cardiac Surgery, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.

Background: The incidence of Ebstein's anomaly is extremely low, and except for the Mayo Clinic, no cardiac center has reported on a sufficient number of patients. The aim of our study was to report the outcomes of Ebstein's anomaly patients treated with tricuspid valvuloplasty (TVP) or tricuspid valve replacement (TVR).

Methods: TVP or TVR was performed in 245 patients from July 2006 to April 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0366-6999.230731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937315PMC
May 2018
16 Reads

Giardia and Cryptosporidium antibody prevalence and correlates of exposure among Alaska residents, 2007-2008.

Epidemiol Infect 2018 05 10;146(7):888-894. Epub 2018 Apr 10.

Arctic Investigations Program, Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention,4055 Tudor Centre Dr, Anchorage, Alaska 99508,USA.

Giardia duodenalis and Cryptosporidium spp. are common intestinal protozoa that can cause diarrhoeal disease. Although cases of infection with Giardia and Cryptosporidium have been reported in Alaska, the seroprevalence and correlates of exposure to these parasites have not been characterised. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S095026881800078XDOI Listing
May 2018
8 Reads

An end-to-end framework for real-time automatic sleep stage classification.

Sleep 2018 05;41(5)

Centre for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore.

Sleep staging is a fundamental but time consuming process in any sleep laboratory. To greatly speed up sleep staging without compromising accuracy, we developed a novel framework for performing real-time automatic sleep stage classification. The client-server architecture adopted here provides an end-to-end solution for anonymizing and efficiently transporting polysomnography data from the client to the server and for receiving sleep stages in an interoperable fashion. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/sleep/article/doi/10.1093/sleep/zsy
Publisher Site
http://dx.doi.org/10.1093/sleep/zsy041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946920PMC
May 2018
3 Reads

Identification of clinically relevant phenotypes in patients with Ebstein anomaly.

Clin Cardiol 2018 Mar 22;41(3):343-348. Epub 2018 Mar 22.

Departamento de Investigaciones, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.

Background: Ebstein anomaly (EA) is a heterogeneous congenital heart defect (CHD), frequently accompanied by diverse cardiac and extracardiac comorbidities, resulting in a wide range of clinical outcomes.

Hypothesis: Phenotypic characterization of EA patients has the potential to identify variables that influence prognosis and subgroups with distinct contributing factors.

Methods: A comprehensive cross-sectional phenotypic characterization of 147 EA patients from one of the main referral institutions for CHD in Colombia was carried out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/clc.22870DOI Listing
March 2018
9 Reads

Iatrogenic Ventricular Fibrillation after Direct-Current Cardioversion of Preexcited Atrial Fibrillation Caused by Inadvertent T-Wave Synchronization.

Tex Heart Inst J 2018 02 1;45(1):39-41. Epub 2018 Feb 1.

Direct-current cardioversion is an important means of managing arrhythmias. During treatment, carefully synchronizing energy delivery to the QRS complex is necessary to avoid ventricular fibrillation caused by a shock during the vulnerable period of ventricular repolarization, that is, a shock on the T wave. The presence of an accessory pathway and ventricular preexcitation can lead to difficulty in distinguishing the QRS complex from the T wave because of bizarre, wide, irregular QRS complexes and prominent repolarization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14503/THIJ-16-6162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832085PMC
February 2018
6 Reads

Thalamocortical dysrhythmia detected by machine learning.

Nat Commun 2018 03 16;9(1):1103. Epub 2018 Mar 16.

Unit of Neurosurgery, Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.

Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological disorders. It is characterized by a common oscillatory pattern in which resting-state alpha activity is replaced by cross-frequency coupling of low- and high-frequency oscillations. We undertook a data-driven approach using support vector machine learning for analyzing resting-state electroencephalography oscillatory patterns in patients with Parkinson's disease, neuropathic pain, tinnitus, and depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-02820-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856824PMC
March 2018
3 Reads

Effects of 99mTc-TRODAT-1 drug template on image quantitative analysis.

PLoS One 2018 15;13(3):e0194503. Epub 2018 Mar 15.

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.

99mTc-TRODAT-1 is a type of drug that can bind to dopamine transporters in living organisms and is often used in SPCT imaging for observation of changes in the activity uptake of dopamine in the striatum. Therefore, it is currently widely used in studies on clinical diagnosis of Parkinson's disease (PD) and movement-related disorders. In conventional 99mTc-TRODAT-1 SPECT image evaluation, visual inspection or manual selection of ROI for semiquantitative analysis is mainly used to observe and evaluate the degree of striatal defects. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854413PMC
July 2018
3 Reads

Impulse control disorders in Parkinson's: Sleep disorders and nondopaminergic associations.

Brain Behav 2018 03 10;8(3):e00904. Epub 2018 Feb 10.

Department of Neurology Center for Movement Disorders and Neurorestoration University of Florida Gainesville FL USA.

Objectives: Impulse control disorders (ICDs) are common among patients with Parkinson's disease (PD). Risk factors identified for developing ICDs include young age, family history, and impulsive personality traits. However, the association of these potentially disabling disorders with nondopaminergic drugs and sleep disorders has been understudied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/brb3.904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840436PMC
March 2018
14 Reads

Prevalence of Helicobacter pylori among Alaskans: Factors associated with infection and comparison of urea breath test and anti-Helicobacter pylori IgG antibodies.

Helicobacter 2018 Jun 14;23(3):e12482. Epub 2018 Mar 14.

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA.

Background: Helicobacter pylori is one of the most common human infections in the world, and studies in Alaska Native people, as well as other Indigenous peoples, have shown a high prevalence of this gastric infection. This study was undertaken to determine the prevalence of H. pylori infection by urea breath test (UBT) and anti- H. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hel.12482DOI Listing
June 2018
5 Reads

Direct localisation of the human pedunculopontine nucleus using MRI: a coordinate and fibre-tracking study.

Eur Radiol 2018 Sep 12;28(9):3882-3892. Epub 2018 Mar 12.

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China.

Objectives: To image the pedunculopontine tegmental nucleus (PPN), a deep brain stimulation (DBS) target for Parkinson disease, using MRI with validated results.

Methods: This study used the MP2RAGE sequence with high resolution and enhanced grey-white matter contrast on a 7-T ultra-high-field MRI system to image the PPN as well as a diffusion spectrum imaging method on a 3-T MRI system to reconstruct the main fibre systems surrounding the PPN. The coordinates of the rostral and caudal PPN poles of both sides were measured in relation to the third and fourth ventricular landmarks on the 7-T image. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-017-5299-5DOI Listing
September 2018
29 Reads
4.014 Impact Factor

Influence of Music Style and Rate on Repetitive Finger Tapping.

Motor Control 2018 Oct 9;22(4):472-485. Epub 2018 Mar 9.

1 Iowa State University.

Auditory cues, including music, are commonly used in the treatment of persons with Parkinson's disease. Yet, how music style and movement rate modulate movement performance in persons with Parkinson's disease have been neglected and remain limited in healthy young populations. The purpose of this study was to determine how music style and movement rate influence movement performance in healthy young adults. Read More

View Article

Download full-text PDF

Source
https://journals.humankinetics.com/doi/10.1123/mc.2017-0081
Publisher Site
http://dx.doi.org/10.1123/mc.2017-0081DOI Listing
October 2018
2 Reads

Effect of virtual reality in Parkinson's disease: a prospective observational study.

Arq Neuropsiquiatr 2018 Feb;76(2):78-84

Universidade Tuiuti do Paraná, Departamento de Otoneurologia, Curitiba PR, Brasil.

Objective: To assess the effectiveness of balance exercises by means of virtual reality games in Parkinson's disease.

Methods: Sixteen patients were submitted to anamnesis, otorhinolaryngological and vestibular examinations, as well as the Dizziness Handicap Inventory, Berg Balance Scale, SF-36 questionnaire, and the SRT, applied before and after rehabilitation with virtual reality games.

Results: Final scoring for the Dizziness Handicap Inventory and Berg Balance Scale was better after rehabilitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0004-282X20170195DOI Listing
February 2018

Deep Brain Stimulation of the Subthalamic Nucleus Does Not Affect the Decrease of Decision Threshold during the Choice Process When There Is No Conflict, Time Pressure, or Reward.

J Cogn Neurosci 2018 06 28;30(6):876-884. Epub 2018 Feb 28.

University of Oxford.

During a decision process, the evidence supporting alternative options is integrated over time, and the choice is made when the accumulated evidence for one of the options reaches a decision threshold. Humans and animals have an ability to control the decision threshold, that is, the amount of evidence that needs to be gathered to commit to a choice, and it has been proposed that the subthalamic nucleus (STN) is important for this control. Recent behavioral and neurophysiological data suggest that, in some circumstances, the decision threshold decreases with time during choice trials, allowing overcoming of indecision during difficult choices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1162/jocn_a_01252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037388PMC
June 2018
2 Reads

Atypical presentation of dopa-responsive dystonia in Taiwan.

Brain Behav 2018 02 20;8(2):e00906. Epub 2018 Jan 20.

Department of Neurology Chang Gung Memorial Hospital Chang-Gung University College of Medicine Taipei Taiwan.

The typical clinical presentation of dopa-responsive dystonia, which is also called Segawa disease, is a young age of onset, with predominance in females, diurnal fluctuation of lower limb dystonia, and fair response to low-dose levodopa. This disease has both autosomal dominant and autosomal recessive inheritance. Autosomal dominant Segawa disease is caused by mutation on chromosome 14q22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/brb3.906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822572PMC
February 2018
2 Reads

Clinical characteristics and quality of life in Chinese patients with Parkinson's disease beyond 20 years.

Neurol Res 2018 Apr 15;40(4):312-317. Epub 2018 Feb 15.

a Department of Neurology , West China Hospital, Sichuan University , Chengdu , China.

Background The number of Parkinson's disease (PD) patients with disease duration of more than 20 years (long disease duration PD, LPD) is on the rise. Objectives This study aims to describe the clinical profiles and the quality of life (QoL) of LPD patients from a cohort of the Chinese population. Methods We compared 71 LPD subjects to 60 PD patients who died less than 20 years after the onset of PD (control PD, CPD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01616412.2018.1438227DOI Listing
April 2018
3 Reads

The epidemiology of Parkinson's disease in the Italian region Friuli Venezia Giulia: a population-based study with administrative data.

Neurol Sci 2018 Apr 9;39(4):699-704. Epub 2018 Feb 9.

Neurology Unit, Neuroscience Department, "S. Maria della Misericordia" University Hospital of Udine, Udine, Italy.

Parkinson's disease is known to pose a relevant burden to society in industrialized countries. However, not much research has been conducted on the epidemiology of this disease in Italy. Our aim was to estimate the incidence rate and prevalence of Parkinson's disease in the Italian Friuli Venezia Giulia region using administrative health-related databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-018-3273-xDOI Listing
April 2018
2 Reads

How many strides are required for a reliable estimation of temporal gait parameters? Implementation of a new algorithm on the phase coordination index.

PLoS One 2018 8;13(2):e0192049. Epub 2018 Feb 8.

Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel.

Background: The Phase coordination index (PCI), a temporal gait measure that quantifies consistency and accuracy in generating the anti-phased left-right stepping pattern, assesses bilateral coordination of gait in various cohorts (e.g., Parkinson's disease, post stroke). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192049PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805232PMC

Assessment of Snaith-Hamilton Pleasure Scale (SHAPS): the dimension of anhedonia in Italian healthy sample.

Neurol Sci 2018 Apr 30;39(4):657-661. Epub 2018 Jan 30.

National Research Council (IBFM-CNR), Institute of Molecular Bioimaging and Physiology, Viale Europa, 88100, Catanzaro, Italy.

The Snaith-Hamilton Pleasure Scale (SHAPS) is a rapid screening battery created for assessing the presence of anhedonia, namely the inability to experience pleasure. Although, this symptom has widely been investigated in clinical settings, individual differences in anhedonia are also present in healthy population. The aim of present study was to validate the translated Italian version of this test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-018-3260-2DOI Listing
April 2018
5 Reads

A Common Function of Basal Ganglia-Cortical Circuits Subserving Speed in Both Motor and Cognitive Domains.

eNeuro 2017 Nov-Dec;4(6). Epub 2017 Dec 8.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Distinct regions of the frontal cortex connect with their basal ganglia and thalamic counterparts, constituting largely segregated basal ganglia-thalamo-cortical (BTC) circuits. However, any common role of the BTC circuits in different behavioral domains remains unclear. Indeed, whether dysfunctional motor and cognitive BTC circuits are responsible for motor slowing and cognitive slowing, respectively, in Parkinson's disease (PD) is a matter of debate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/ENEURO.0200-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783269PMC
December 2018
3 Reads

Slower saccadic reading in Parkinson's disease.

PLoS One 2018 24;13(1):e0191005. Epub 2018 Jan 24.

Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, United States of America.

Idiopathic Parkinson's Disease (PD) is characterized by degeneration of dopaminergic and other neurons, leading to motor and non-motor deficits. Abnormal eye movements in PD, including fixations, saccades, and convergence, are well described. However, saccadic reading, which requires serial and alternating saccades and fixations, is not well studied, despite its obvious impact on the quality of life. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783375PMC
February 2018
4 Reads