92,390 results match your criteria Parkinson Disease in Young Adults


Lrrk2 modulation of Wnt signaling during zebrafish development.

J Neurosci Res 2020 Jul 5. Epub 2020 Jul 5.

Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, USA.

Mutations in leucine-rich repeat kinase 2 (lrrk2) are the most common genetic cause of Parkinson's disease. Difficulty in elucidating the pathogenic mechanisms resulting from disease-associated Lrrk2 variants stems from the complexity of Lrrk2 function and activities. Lrrk2 contains multiple protein-protein interacting domains, a GTPase domain, and a kinase domain. Read More

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http://dx.doi.org/10.1002/jnr.24687DOI Listing

[Caregiver burden in patients with Parkinson's disease].

Authors:
Gerhard Ransmayr

Fortschr Neurol Psychiatr 2020 Jul 5. Epub 2020 Jul 5.

Parkinson patients suffering from disease progression become increasingly dependent on personal care, which is mostly provided by female family members. Burden of care correlates with severity of motor impairment, neurocognitive and neuropsychiatric symptoms, behavioral abnormalities, autonomic nervous system disorders, impairment of micturition, sleep, and dependence. Caregiver burden also results from restrictions in time for personal matters, family, leisure and social activities, occupational limits, costs, lack of social support and impairment of sleep, depression, and emotional and other health problems of the carer (such as depression and anxiety). Read More

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http://dx.doi.org/10.1055/a-1120-8567DOI Listing

Bi-allelic variants in PNPLA6 possibly associated with Parkinsonian features in addition to spastic paraplegia phenotype.

J Neurol 2020 Jul 4. Epub 2020 Jul 4.

Parkinson Disease and Movement Disorders Program, Department of Neurology, Medical Faculty Associates, George Washington University, Washington, DC, USA.

Variants in the PNPLA6 gene are known to cause 4 distinct phenotypes. One known phenotype is Hereditary Spastic Paraplegia type 39 (HSP 39), a rare neurodegenerative condition characterized by variable onset of lower limb spasticity, weakness and ataxia. Little is known about complications of HSP 39 in adulthood. Read More

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http://dx.doi.org/10.1007/s00415-020-10028-wDOI Listing

Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism.

iScience 2020 Jun 19;23(7):101284. Epub 2020 Jun 19.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Despite intensive research on Parkinson disease (PD) for decades, this common neurodegenerative disease remains incurable. We hypothesize that abnormal iron accumulation is a common thread underlying the emergence of the hallmarks of PD, namely mitochondrial dysfunction and α-synuclein accumulation. We investigated the powerful action of the main iron regulator hepcidin in the brain. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101284DOI Listing

Orofacial dystonia and associated bulbar symptoms in multiple system atrophy: A blinded video analysis.

J Neurol Sci 2020 Jun 24:116995. Epub 2020 Jun 24.

Department of Neurosciences, UC, Riverside, CA, USA; The Parkinson and Movement Disorder Institute, Orange Coast Memorial Medical Center, Fountain Valley, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2020.116995DOI Listing

Novel decision algorithm to discriminate parkinsonism with combined blood and imaging biomarkers.

Parkinsonism Relat Disord 2020 Jun 22;77:57-63. Epub 2020 Jun 22.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:

Introduction: To determine an exploratory multimodal approach including serum NFL and MR planimetric measures to discriminate Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP).

Methods: MR planimetric measurements and NFL serum levels, with a mean time interval of 60 months relative to symptom onset, were assessed in a retrospective cohort of 11 progressive supranuclear palsy (PSP), 22 Parkinson's disease (PD), 16 multiple system atrophy (MSA) patients and 42 healthy controls (HC). A decision tree model to discriminate PD, PSP, and MSA was constructed using receiver operating characteristic curve analysis and Classification and Regression Trees algorithm. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.05.033DOI Listing

Age-dependent efficacy of subthalamic nucleus deep brain stimulation in young- and late-onset Parkinson's disease based on a 10 year follow-up.

J Neurol Sci 2020 Jun 25;416:117004. Epub 2020 Jun 25.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. Electronic address:

Introduction: Long-term efficacy and safety of subthalamic nucleus deep brain stimulation (STN DBS) in patients with young-onset Parkinson's disease (YOPD) and late-onset PD (LOPD) (i.e. motor symptom initial appearance at ages ≤40 and > 40 years, respectively) was compared to identify relationships between PD onset age and the efficacy of DBS. Read More

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http://dx.doi.org/10.1016/j.jns.2020.117004DOI Listing

In Vivo Molecular Signatures of Cerebellar Pathology in Spinocerebellar Ataxia Type 3.

Mov Disord 2020 Jul 4. Epub 2020 Jul 4.

Center for Magnetic Resonance Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.

Background: No treatment exists for the most common dominantly inherited ataxia Machado-Joseph disease, or spinocerebellar ataxia type 3 (SCA3). Successful evaluation of candidate therapeutics will be facilitated by validated noninvasive biomarkers of disease pathology recapitulated by animal models.

Objective: We sought to identify shared in vivo neurochemical signatures in two mouse models of SCA3 that reflect the human disease pathology. Read More

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http://dx.doi.org/10.1002/mds.28140DOI Listing

Gabapentin and memantine increases randomness of oscillatory waveform in ocular palatal tremor.

J Comput Neurosci 2020 Jul 3. Epub 2020 Jul 3.

Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.

Syndrome of oculopalatal tremor (OPT) causes pendular nystagmus of the eyes and its disabling consequence on the visual system. Classic pharmacotherapeutic studies revealed reduction in the eye velocity of the oscillatory waveforms. Subjective improvement in vision, however, remains out of proportionately low. Read More

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http://dx.doi.org/10.1007/s10827-020-00753-6DOI Listing

Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.

J Formos Med Assoc 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan City, Taiwan; School of Medicine, Chang Gung University, Taoyuan City, Taiwan. Electronic address:

Background: Oxidative stress could participate in the pathogenesis of Parkinson's disease (PD). However, the role of genetic variation of superoxide dismutase 2 (SOD2), an important regulator against oxidative stress, in PD remains to be elucidated.

Methods: We screened SOD2 gene variation by sequencing cDNA from 72 patients with early onset PD. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.06.023DOI Listing

Transcranial magnetic stimulation and gait disturbances in Parkinson's disease: A systematic review.

Neurophysiol Clin 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurorehabilitation, Hospital of Vipiteno, Vipiteno, Italy; Research Unit for Neurorehabilitation South Tyrol, Bolzano, Italy.

Transcranial magnetic stimulation (TMS) may offer a reliable means of characterizing important pathophysiologic aspects of motor impairments in Parkinson's disease (PD). Moreover, high-frequency repetitive TMS (rTMS), especially if delivered bilaterally over motor cortical regions, can have beneficial effects on parkinsonian motor symptoms. However, only a few studies have investigated the effects of rTMS on freezing of gait (FOG) and other gait disturbances in PD. Read More

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http://dx.doi.org/10.1016/j.neucli.2020.05.002DOI Listing

Cognition, function and awareness of disease impact in early Parkinson's and Huntington's disease.

Disabil Rehabil 2020 Jul 3:1-19. Epub 2020 Jul 3.

University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal.

Patients with Parkinson's and Huntington's Disease (PD and HD) present impairments in cognitively challenging everyday activities. This study contrasts these two basal ganglia disorders on the ability to perform daily life- like tasks and their level of awareness regarding the disease impact on function. 19 controls, 10 early-onset PD, 20 early stage PD, and 15 early manifest HD patients were compared in the "EcoKitchen," a virtual reality task with increasing executive load, the "Behavioural Assessment of Dysexecutive Syndrome battery - BADS," and "The Adults and Older Adults Functional Assessment Inventory - IAFAI," a self-report functional questionnaire. Read More

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http://dx.doi.org/10.1080/09638288.2020.1783001DOI Listing

A wearable tool for selective and continuous monitoring of tremor and dyskinesia in Parkinsonian patients.

Parkinsonism Relat Disord 2020 Jun 23;77:43-47. Epub 2020 Jun 23.

Department of Neurosurgery, Neurology Unit, Hospital of Potenza "San Carlo", Via Potito Petrone, Potenza, Italy.

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http://dx.doi.org/10.1016/j.parkreldis.2020.06.020DOI Listing

Impact of rasagiline nanoparticles on brain targeting efficiency via gellan gum based transdermal patch: A nanotheranostic perspective for Parkinsonism.

Int J Biol Macromol 2020 Jun 30. Epub 2020 Jun 30.

University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, Maharashtra, India.

Rasagiline mesylate is used as first line agent for early management of Parkinson's disease but its water soluble nature creates hurdles to cross blood brain barrier also its low oral bioavailability and rapid elimination requires frequent dosing. Thus present study aims to prepare rasagiline mesylate-nanoparticles (RM-NPs) loaded gellan gum transdermal film for non-invasive; self-administration in elderly patients. PLGA coated RM-NPs prepared by solvent evaporation technique were incorporated into film prepared by solvent casting method. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.261DOI Listing

Benefits of powered standing wheelchair devices for adolescents with Duchenne muscular dystrophy in the first year of use.

J Paediatr Child Health 2020 Jul 3. Epub 2020 Jul 3.

School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia.

Aim: Poorer physical and mental health often accompany loss of walking in Duchenne muscular dystrophy. This study assessed the impacts of powered wheelchair standing device (PWSD) use on muscle and joint pain, joint angles when standing and mental health in adolescents with Duchenne muscular dystrophy.

Methods: Fourteen adolescents and parents participated in a stepped wedge design study over 12 months. Read More

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http://dx.doi.org/10.1111/jpc.14963DOI Listing

A Large-Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands.

Mov Disord 2020 Jul 2. Epub 2020 Jul 2.

Centre for Human Drug Research, Leiden, The Netherlands.

Background: The most common genetic risk factor for Parkinson's disease known is a damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a large cohort from a single population. The objective of this study was to assess the entire GBA1 gene in Parkinson's disease from a single large population. Read More

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http://dx.doi.org/10.1002/mds.28112DOI Listing

Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice.

Mov Disord 2020 Jul 3. Epub 2020 Jul 3.

Centre for Neuroscience, Indian Institute of Science, Bangalore, India.

Background: Parkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol redox homeostasis has been shown to play a role in the dysregulation of cell death and cell survival signaling pathways in these neurons. Glutaredoxin 1 (Grx1) is a thiol/disulfide oxidoreductase that catalyzes the deglutathionylation of proteins and is important for regulation of cellular protein thiol redox homeostasis. Read More

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http://dx.doi.org/10.1002/mds.28190DOI Listing

Wilson's Disease in Finland: A Nationwide Population-Based Study.

Mov Disord 2020 Jul 2. Epub 2020 Jul 2.

Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland.

Background: Data on the epidemiology and prognosis of Wilson's disease are scarce, and no clinical data are available from Finland.

Methods: All persons diagnosed and treated for Wilson's disease in Finnish hospitals in 1998 to 2017 were identified. Data were collected from national registries and patient charts. Read More

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http://dx.doi.org/10.1002/mds.28207DOI Listing

Glial cells in Parkinson´s disease: protective or deleterious?

Cell Mol Life Sci 2020 Jul 2. Epub 2020 Jul 2.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.

Glial cells have been identified more than 100 years ago, and are known to play a key role in the central nervous system (CNS) function. A recent piece of evidence is emerging showing that in addition to the capacity of CNS modulation and homeostasis, glial cells are also being looked like as a promising cell source not only to study CNS pathologies initiation and progression but also to the establishment and development of new therapeutic strategies. Thus, in the present review, we will discuss the current evidence regarding glial cells' contribution to neurodegenerative diseases as Parkinson's disease, providing cellular, molecular, functional, and behavioral data supporting its active role in disease initiation, progression, and treatment. Read More

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http://dx.doi.org/10.1007/s00018-020-03584-xDOI Listing

Single-shot cryoablation of an epicardial inferoparaseptal accessory pathway: a case report.

Eur Heart J Case Rep 2020 Jun 17;4(3):1-6. Epub 2020 Apr 17.

Department of Heart Rhythm and Conduction Disorder, National Medical Research Center for Preventive Medicine, Petroverigskiy Lane 10-3, Moscow 101000, Russia.

Background: Catheter ablation (CA) of epicardial accessory pathways (APs) can be performed via the coronary sinus (CS) system. Variable CS anatomy with complications of former CA procedures inside the CS venous system may require using alternative CA approach and technology.

Case Summary: We report the case of a 23-year-old man with Wolff-Parkinson-White syndrome and history of aborted sudden cardiac death (SCD) and unsuccessful previous AP radiofrequency ablation (RFA). Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319811PMC

Effects of effortful swallowing on cardiac autonomic control in individuals with neurogenic dysphagia: a prospective observational analytical study.

Sci Rep 2020 Jul 2;10(1):10924. Epub 2020 Jul 2.

Department of Speech, Hearing and Language Pathology, UNESP, Marilia, Brazil.

Considering that neurogenic oropharyngeal dysphagia is a prevalent condition with or without cardiac disease we should contemplate issues surrounding cardiovascular difficulties during rehabilitation. This study aims to evaluate the effects of effortful swallowing maneuver (ESM) on heart rate variability (HRV) in subjects with neurogenic oropharyngeal dysphagia. We studied 22 individuals [8 Stroke and 14 Parkinson Disease (PD) subjects aged between 41 and 75 years old] with neurogenic oropharyngeal dysphagia regardless of gender. Read More

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http://dx.doi.org/10.1038/s41598-020-67903-9DOI Listing

Patterns of striatal dopamine depletion in early Parkinson disease: Prognostic relevance.

Neurology 2020 Jul 2. Epub 2020 Jul 2.

From the Department of Neurology (S.J.C., H.S.Y., Y.H.L., P.H.L., Y.H.S.) and Biostatistics Collaboration Unit (H.S.L.), Yonsei University College of Medicine, Seoul, South Korea.

Objective: To investigate whether the patterns of striatal dopamine depletion on dopamine transporter (DAT) scans could provide information on the long-term prognosis in Parkinson disease (PD).

Methods: We enrolled 205 drug-naive patients with early-stage PD, who underwent F-FP-CIT PET scans at initial assessment and received PD medications for 3 or more years. After quantifying the DAT availability in each striatal subregion, factor analysis was conducted to simplify the identification of striatal dopamine depletion patterns and to yield 4 striatal subregion factors. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009878DOI Listing

ER-associated Protein Degradation at Atomic Resolution.

Trends Biochem Sci 2020 Jun 29. Epub 2020 Jun 29.

Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2H7, Canada. Electronic address:

The endoplasmic reticulum-associated degradation (ERAD) pathway eliminates misfolded proteins. The Hrd1 complex represents the main gate mediating retrotranslocation of ER luminal misfolded (ERAD-L) substrates to the cytosol. A recent cryo-electron microscopy (cryo-EM) study by Wu et al. Read More

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http://dx.doi.org/10.1016/j.tibs.2020.06.005DOI Listing

Minimally Invasive Scoliosis Correction in Parkinson Disease: Retrospective Case Series.

Oper Neurosurg (Hagerstown) 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurosurgery, Rush University Medical Center, Rush University, Chicago, Illinois.

Background: Parkinson disease (PD) is the second most common neurodegenerative disease in the United States. In the context of the disability inherent to PD, the additional physical challenges and pain from scoliosis can be debilitating for these patients. However, the magnitude of surgery required to correct the deformity combined with the medical co-morbidities and frailty in this population of patients makes surgery very risky. Read More

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http://dx.doi.org/10.1093/ons/opaa187DOI Listing

High lithium levels in tobacco, incidences of Parkinson's disease and melanoma: Mechanism of the association.

Authors:
Tomoyuiki Kawada

Med Hypotheses 2020 Jun 28;143:110045. Epub 2020 Jun 28.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2020.110045DOI Listing

DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study.

Parkinsonism Relat Disord 2020 Jun 22;77:36-42. Epub 2020 Jun 22.

1st Neurology Clinic, Eginition Hospital, Athens University Medical School, Athens, Greece. Electronic address:

Introduction: It has been reported that early onset Parkinson's Disease (PD) patients have a less profound dopaminergic degeneration. The aim of the current study was to determine whether there are longitudinal differences in dopaminergic denervation [signal reduction in 123I-FP-CIT SPECT] in early versus mid and late onset PD.

Methods: DaTSCAN (123I-FP-CIT SPECT) imaging was acquired at Parkinson's Progression Markers Initiative (PPMI) imaging centers and sent to the imaging core for calculation of striatal binding ratios. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.06.019DOI Listing

Progressive and accelerated weight and body fat loss in Parkinson's disease: A three-year prospective longitudinal study.

Parkinsonism Relat Disord 2020 Jun 20;77:28-35. Epub 2020 Jun 20.

Division of Neurology, Department of Medicine, and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Introduction: Although weight loss is common in Parkinson's disease (PD), longitudinal studies assessing weight and body composition changes are limited.

Methods: In this three-year longitudinal study, 125 subjects (77 PD patients and 48 spousal/sibling controls) underwent clinical, biochemical and body composition assessments using dual-energy X-ray absorptiometry.

Results: Patients were older than controls (65. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.06.015DOI Listing

Increased Noradrenaline as an Additional Cerebrospinal Fluid Biomarker in PSP-Like Parkinsonism.

Front Aging Neurosci 2020 16;12:126. Epub 2020 Jun 16.

Department of Experimental Medicine and Surgery, Faculty of Medicine and Surgery, University Tor Vergata, Rome, Italy.

Academic centers utilize sequential clinical and neuroimaging assessments, including morphometric ratios, to obtain an unequivocal diagnosis of the non-synucleinopathic forms of Parkinsonism, such as progressive supranuclear palsy (PSP), however, a 1-2 year follow-up is required. The on-going long-lasting trials using anti-tau antibodies for PSP patients might therefore be biased by the incorrect enrollment of Parkinson's disease (PD) patients manifesting early axial signs. This perspective study aimed at achieving two major goals: first, to summarize the established biomarker candidates found in cerebrospinal fluid (CSF) in probable PSP patients, including low p-tau and altered neurofilaments. Read More

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http://dx.doi.org/10.3389/fnagi.2020.00126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308889PMC

LRRK2 Phosphorylation, More Than an Epiphenomenon.

Front Neurosci 2020 16;14:527. Epub 2020 Jun 16.

University of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille, France.

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are associated with an increased risk for sporadic PD. This gene encodes a kinase that is physiologically multiphosphorylated, including clusters of both heterologous phosphorylation and autophosphorylation sites. Several pieces of evidence indicate that LRRK2's phosphorylation is important for its pathological and physiological functioning. Read More

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http://dx.doi.org/10.3389/fnins.2020.00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308437PMC

Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation.

Sci Rep 2020 Jul 1;10(1):10755. Epub 2020 Jul 1.

Biodefense Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.

Nurr1, a transcription factor belonging to the orphan nuclear receptor, has an essential role in the generation and maintenance of dopaminergic neurons and is important in the pathogenesis of Parkinson' disease (PD). In addition, Nurr1 has a non-neuronal function, and it is especially well known that Nurr1 has an anti-inflammatory function in the Parkinson's disease model. However, the molecular mechanisms of Nurr1 have not been elucidated. Read More

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http://dx.doi.org/10.1038/s41598-020-67549-7DOI Listing

Dementia and subthalamic deep brain stimulation in Parkinson disease: A long-term overview.

Neurology 2020 Jul 1. Epub 2020 Jul 1.

From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.

Objectives: To assess the prevalence and the cumulative incidence of dementia at short-, medium- and long-term follow-up after deep brain stimulation (DBS) of the subthalamic nucleus (STN) (at 1, 5, and 10 years) and to evaluate potential risk factors for postoperative dementia.

Methods: The presence of dementia (according to the DSM-V) was retrospectively evaluated at each postoperative follow-up in patients with Parkinson disease (PD) who underwent bilateral STN-DBS. Preoperative and perioperative risk factors of developing postoperative dementia were also investigated. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009822DOI Listing

Association Between Glycemic Status and the Risk of Parkinson Disease: A Nationwide Population-Based Study.

Diabetes Care 2020 Jul 1. Epub 2020 Jul 1.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

Objective: Previous studies have suggested that diabetes increases the risk of Parkinson disease (PD); however, this has not been conclusively established. We analyzed the risk of PD based on baseline glucose tolerance status in a large-scale cohort representative of the general Korean population.

Research Design And Methods: This analysis was performed in a cohort of 15,168,021 adults aged ≥40 years who underwent health checkups under the National Health Insurance Service between January 2009 and December 2010. Read More

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http://dx.doi.org/10.2337/dc19-0760DOI Listing

The protective effect of decoction of Rehmanniae via PI3K/Akt/mTOR pathway in MPP-induced Parkinson's disease model cells.

J Recept Signal Transduct Res 2020 Jul 2:1-11. Epub 2020 Jul 2.

Department of Emergency, First People's Hospital of Jingmen, Jingmen, China.

This research aims to explore the function of DOR in 1-methyl-4-phenylpyridinium (MPP)-induced Parkinson's disease model cell SH-SY5Y. SH-SY5Y cells were exposed with various doses of MPP + or DOR. Cell counting Kit-8 (CCK-8) assay and flow cytometry (FCM) were used to detect the cell viability, apoptosis and reactive oxygen species (ROS) levels in MPP Parkinson's disease model cells SH-SY5Y. Read More

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http://dx.doi.org/10.1080/10799893.2020.1787445DOI Listing

Dysphagia in Parkinsonism: Prevalence, Predictors and Correlation with Severity of Illness Fasting).

J Assoc Physicians India 2020 May;68(5):22-25

Associate Professor, Department of Medicine, LTMMC and GH, Mumbai, Maharashtra.

Introduction: Dysphagia is frequently present in Parkinsonian syndromes and is associated with increased morbidity and mortality. Early identification of swallowing dysfunction is critical to minimize complications like aspiration pneumonia and malnutrition. Published prevalence rates for dysphagia in Parkinsonian syndromes vary widely with a very few studies from India. Read More

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[The objective oral health of Parkinson's disease patients].

Ned Tijdschr Tandheelkd 2020 May;127(5):318-322

In this article, the results of a research project on the objective oral health of Parkinson's disease patients, related to the duration and the progression of the disease, are reported. Participants were 74 patients with Parkinson's disease and 74 control persons. All participants were orally examined. Read More

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http://dx.doi.org/10.5177/ntvt.2020.05.19131DOI Listing

Understanding voluntariness of consent in first-in-human cell therapy trials.

Authors:
Kristina Hug

Regen Med 2020 Jul 1. Epub 2020 Jul 1.

Medical Ethics, Department of Clinical Sciences, Faculty of Medicine, Lund University, BMC I12, 22184 Lund, Sweden.

Consensus about contents of voluntariness in informed consent is lacking. Core criteria for voluntary consent are needed to ensure voluntariness. This article outlines the multidimensionality of voluntariness and identifies what could reduce voluntariness, especially in first-in-human clinical trials involving cell therapies. Read More

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http://dx.doi.org/10.2217/rme-2019-0126DOI Listing

Is an Isolated Weight-Holding Tremor a New Subtype of Isometric Tremor?

Yonsei Med J 2020 Jul;61(7):644-646

Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

A weight-holding tremor is a rare type of hand tremor that occurs only when someone holds some weight. Here we report three cases of isolated weight-holding tremors, of which one patient was diagnosed with Parkinson's disease (PD) and the others as a variant of essential tremor (ET). A 68-year-old woman presented with a left-hand tremor that appeared only when she held objects with some weight. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.7.644DOI Listing

Altered structure and functional connectivity of the central autonomic network in idiopathic rapid eye movement sleep behaviour disorder.

J Sleep Res 2020 Jun 30:e13136. Epub 2020 Jun 30.

Department of Neurology, Institute of Neurology, Ruijin Hospital/Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Evidence suggests peripheral autonomic structures may contribute to autonomic dysfunction in idiopathic rapid eye movement sleep behaviour disorder (iRBD). However, whether the central autonomic network (CAN) is affected in iRBD remains unclear. Magnetic resonance imaging data were acquired from 65 participants (32 patients with iRBD and 33 matched healthy controls). Read More

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http://dx.doi.org/10.1111/jsr.13136DOI Listing

Enhancing the Activity of Glucocerebrosidase as a Treatment for Parkinson Disease.

CNS Drugs 2020 Jul 1. Epub 2020 Jul 1.

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.

Mutations in the glucocerebrosidase (GBA1) gene are the most common genetic risk factor for Parkinson disease (PD). Homozygous or compound heterozygous GBA1 mutations cause the lysosomal storage disorder Gaucher disease (GD), characterized by deficient activity of the glucocerebrosidase enzyme (GCase). Both individuals with GD type I and heterozygous carriers of pathogenic variants of GBA1 have an increased risk of developing PD, by approximately ten- to 20-fold compared to non-carriers. Read More

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http://dx.doi.org/10.1007/s40263-020-00746-0DOI Listing

Sacral Neuromodulation in a Patient with Wolff-Parkinson-White Syndrome: A Case Report.

Res Rep Urol 2020 17;12:193-197. Epub 2020 Jun 17.

Department of Urology, College of Medicine, Majmaah University, Al-Majmaah, Saudi Arabia.

Sacral neuromodulation has gained widespread use for bladder overactivity, frequency, urgency, fecal incontinence, and nonobstructive urinary retention; hence, implantations of this device in patients with comorbid cardiac conduction diseases have increased. Theoretically, there are some concerns regarding the use of sacral neuromodulation implants in patients with Wolf-Parkinson-White syndrome and cardiac conduction diseases because of the risk of interference with electrical impulses. This study aimed to describe the safety of using sacral neuromodulation to treat nonobstructive urinary retention in patients with a cardiac conduction disease. Read More

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http://dx.doi.org/10.2147/RRU.S258403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308758PMC

Impact of Levodopa in Lung Functions in Patients with Parkinson Disease.

Ann Indian Acad Neurol 2020 May-Jun;23(3):338-341. Epub 2020 Jun 10.

Department of Medicine, Army College of Medical Sciences, Delhi Cantt, New Delhi, India.

Background: Parkinson's disease (PD) is the second-most common neurodegenerative disorder known primarily by its motor symptomatology. These motor manifestations are also hypothesised to affect the respiratory muscular function of PD patients contributing to restrictive pattern of ventilatory dysfunction. Previous reports attempting to detect these abnormalities through spirometric assessments have been inconclusive. Read More

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http://dx.doi.org/10.4103/aian.AIAN_88_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313576PMC

The Effect of Dual Tasking and Deep Brain Stimulation Frequency Parameters on Gait in Advanced Parkinson's Disease.

Ann Indian Acad Neurol 2020 May-Jun;23(3):308-312. Epub 2020 Jun 10.

Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Objective: To study the effect of dual tasking and deep brain stimulation frequency parameters on gait in advanced Parkinson's disease.

Materials And Methods: This is an open label interventional study evaluating 40 post STN-DBS patients with gait disturbances. All patients were diagnosed as PD by a movement disorder specialist using the United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) criteria. Read More

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http://dx.doi.org/10.4103/aian.AIAN_11_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313555PMC

Prevalence of Non-motor Symptoms in Parkinson's Disease and Its Impact on Quality of Life in Tertiary Care Center in India.

Ann Indian Acad Neurol 2020 May-Jun;23(3):270-274. Epub 2020 Jun 10.

Department of Neurology, Sri Ramakrishna Hospitals, Coimbatore, Tamil Nadu, India.

Context: Parkinson's disease (PD) is a neurodegenerative disease characterized by traditional motor features. Non-motor symptoms (NMS) are also seen in PD, which inevitably emerge through the disease progression and are often under-recognized and untargeted.

Aims: We studied the prevalence of NMS in PD and their impact on health-related quality of life (HRQoL). Read More

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http://dx.doi.org/10.4103/aian.AIAN_10_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313565PMC

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J Pharmacol Exp Ther 2020 Jun 30. Epub 2020 Jun 30.

Integrative Research Laboratories AB, Sweden.

Here we describe for the first time the distinctive pharmacological profile for IRL752, a new phenyl-pyrrolidine derivative with regio-selective CNS transmission-enhancing properties. IRL752 (3.7-150 μmol/kg, s. Read More

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http://dx.doi.org/10.1124/jpet.120.000037DOI Listing

Dietary Amino Acids Impact LRRK2-induced Neurodegeneration in Parkinson's Disease Models.

J Neurosci 2020 Jun 30. Epub 2020 Jun 30.

Jungers Center for Neurosciences Research, Department of Neurology

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of Parkinson's disease (PD) and results in age-related dopamine neuron loss and locomotor dysfunction in through an aberrant increase in bulk neuronal protein synthesis. Under non-pathologic conditions, protein synthesis is tightly controlled by metabolic regulation. Whether nutritional and metabolic influences on protein synthesis can modulate the pathogenic effect of LRRK2 on protein synthesis and thereby impact neuronal loss is a key unresolved question. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2809-19.2020DOI Listing

Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra.

BMC Neurol 2020 Jun 30;20(1):262. Epub 2020 Jun 30.

Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility mapping (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantitatively comparing the spatial similarity and diagnosis performances for Parkinson's disease (PD).

Methods: QSM and NM-MRI were performed in 18 PD patients and 15 healthy controls (HCs). The setMag images were calculated using the short-echo-time magnitude images. Read More

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http://dx.doi.org/10.1186/s12883-020-01828-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325114PMC

From Mucuna Pruriens to deep brain stimulation: A two-decade case history.

Parkinsonism Relat Disord 2020 Jun 21;77:26-27. Epub 2020 Jun 21.

University of Miami Miller School of Medicine, Department of Neurology, United States.

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http://dx.doi.org/10.1016/j.parkreldis.2020.06.014DOI Listing

Experiences of advance care planning in Parkinson's disease and atypical Parkinsonian disorders: a mixed methods systematic review.

Eur J Neurol 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurology, Institute of Neurology, UCL, London, U.K.

Background: Advance care planning allows people to plan for their future care needs and can include medical, psychological and social aspects. However, little is known on the use, experience of and attitudes towards advance care planning in patients with Parkinsonian disorders, their family carers and in health care professionals.

Methods: We conducted a systematic search of online databases in April 2019 using a narrative synthesis approach with thematic analysis and tabulation to synthesise the findings. Read More

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http://dx.doi.org/10.1111/ene.14424DOI Listing

Parkinson disease clinical subtypes: key features & clinical milestones.

Ann Clin Transl Neurol 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Objectives: Based on multi-domain classification of Parkinson disease (PD) subtypes, we sought to determine the key features that best differentiate subtypes and the utility of PD subtypes to predict clinical milestones.

Methods: Prospective cohort of 162 PD participants with ongoing, longitudinal follow-up. Latent class analysis (LCA) delineated subtypes based on score patterns across baseline motor, cognitive, and psychiatric measures. Read More

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http://dx.doi.org/10.1002/acn3.51102DOI Listing

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease.

Acta Neuropathol 2020 Jun 29. Epub 2020 Jun 29.

Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

Polygenic inheritance plays a central role in Parkinson disease (PD). A priority in elucidating PD etiology lies in defining the biological basis of genetic risk. Unraveling how risk leads to disruption will yield disease-modifying therapeutic targets that may be effective. Read More

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http://dx.doi.org/10.1007/s00401-020-02181-3DOI Listing