1,665 results match your criteria Parkinson Disease in Young Adults


Methamphetamine and heightened risk for early-onset stroke and Parkinson's disease: A review.

Exp Neurol 2021 Jun 21:113793. Epub 2021 Jun 21.

National Drug & Alcohol Research Centre, University of New South Wales, NSW, Australia.

Introduction: Methamphetamine users are typically young adults, placing them at risk for significant drug-related harms. Neurological harms include stroke and Parkinson's disease, both of which may develop prematurely in the context of methamphetamine use.

Material And Methods: We conducted a narrative review examining the evidence first, for stroke under 45 years and second, early onset of Parkinson's disease (PD) and parkinsonism related to methamphetamine use. Read More

View Article and Full-Text PDF

How Common Is the Exponential Decay Pattern of Motor Skill Acquisition? A Brief Investigation.

Motor Control 2021 May 13:1-11. Epub 2021 May 13.

University of Utah.

Motor performance is classically described as improving nonlinearly with practice, demonstrating rapid improvements early in practice with stabilization later, which is commonly modeled by exponential decay functions. However, retrospective analyses of our previously collected data challenge this theoretical model of motor skill acquisition, suggesting that a majority of individual learners actually demonstrate patterns of motor improvement different from this classical model. A convenience sample of young adults, older adults, and people with Parkinson disease trained on the same functional upper-extremity task. Read More

View Article and Full-Text PDF

Strategy to identify priority groups for COVID-19 vaccination: A population based cohort study.

Vaccine 2021 04 26;39(18):2517-2525. Epub 2021 Mar 26.

Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 Center), School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.

Background: Evidence from COVID-19 outbreak shows that individuals with specific chronic diseases are at higher risk of severe prognosis after infection. Public health authorities are developing vaccination programmes with priorities that minimize the risk of mortality and severe events in individuals and communities. We propose an evidence-based strategy that targets the frailest subjects whose timely vaccination is likely to minimize future deaths and preserve the resilience of the health service by preventing infections. Read More

View Article and Full-Text PDF

Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 4-year cohort study.

Lancet Neurol 2021 05 23;20(5):362-372. Epub 2021 Mar 23.

Department of Neurology, RWTH Aachen University, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich and RWTH Aachen University, Aachen, Germany.

Background: The European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) investigates the natural history of Friedreich's ataxia. We aimed to assess progression characteristics and to identify patient groups with differential progression rates based on longitudinal 4-year data to inform upcoming clinical trials in Friedreich's ataxia.

Methods: EFACTS is a prospective, observational cohort study based on an ongoing and open-ended registry. Read More

View Article and Full-Text PDF

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites.

Acta Neuropathol 2021 05 10;141(5):725-754. Epub 2021 Mar 10.

Department of Neurobiology, Duke University, Durham, NC, USA.

The mechanisms by which parkin protects the adult human brain from Parkinson disease remain incompletely understood. We hypothesized that parkin cysteines participate in redox reactions and that these are reflected in its posttranslational modifications. We found that in post mortem human brain, including in the Substantia nigra, parkin is largely insoluble after age 40 years; this transition is linked to its oxidation, such as at residues Cys95 and Cys253. Read More

View Article and Full-Text PDF

Upgrading the evidence for the use of ambroxol in Gaucher disease and GBA related Parkinson: Investigator initiated registry based on real life data.

Am J Hematol 2021 05 11;96(5):545-551. Epub 2021 Mar 11.

Gaucher Unit, Shaare Zedek Medical Center, Jerusalem, Israel.

Ambroxol hydrochloride is an oral mucolytic drug available over-the-counter for many years as cough medicine. In 2009 it was identified as a pharmacological chaperone for mutant glucocerebrosidase, albeit in a several-fold higher dose. Unfortunately, there have been no pharma-driven clinical trials to establish its use. Read More

View Article and Full-Text PDF

The impact of patient narratives on medical students' perceptions of shared decision making: A randomized controlled trial.

Med Educ Online 2021 Dec;26(1):1886642

Knowledge Construction Lab, Leibniz-Institut Fuer Wissensmedien , Tuebingen, Germany.

Successful shared decision making (SDM) in clinical practice requires that future clinicians learn to appreciate the value of patient participation as early as they can in their medical training. Narratives, such as patient testimonials, have been successfully used to support patients' decision-making process. Previous research suggests that narratives may also be used for increasing clinicians' empathy and responsiveness in medical consultations. Read More

View Article and Full-Text PDF
December 2021

Applying available knowledge and resources to alleviate familial and sporadic neurodegenerative disorders.

Authors:
Mark P Mattson

Prog Mol Biol Transl Sci 2021 20;177:91-107. Epub 2020 Oct 20.

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

Here I present the scientific rationale and implementation strategies for elimination of early-onset neurodegenerative disorders (EONDD) from future generations, and for risk reduction and treatments for the more common late-onset neurodegenerative disorders (LONDD). Young adults with a family history of an EONDD should be educated on the genetics and familial burden of EONDD. They can then be genotyped and, if positive for the mutation, counseled as to how they can ensure that none of their children will be affected by choosing either adoption or in vitro fertilization and preimplantation genetic testing. Read More

View Article and Full-Text PDF
October 2020

Dietary Antioxidants and the Risk of Parkinson Disease: The Swedish National March Cohort.

Neurology 2021 02 6;96(6):e895-e903. Epub 2021 Jan 6.

From the Department of Statistics and Quantitative Methods (E.H., R.B.), University of Milano-Bicocca, Milan; Institute for Biomedicine, Eurac Research (E.H.), Affiliated Institute of the University of Lübeck, Bolzano, Italy; Clinical Epidemiology Division, Department of Medicine (Solna) (Y.T.L., S.B.), and Department of Medical Epidemiology and Biostatistics (W.Y., H.-O.A., R.B.), Karolinska Institutet, Stockholm; Obesity Center, Academic Specialist Center (Y.T.L.), Stockholm Health Services, Sweden; Functional Food and Metabolic Stress Prevention Laboratory, Faculty of BioSciences and Technology for Food, Agriculture and Environment (M.S.), University of Teramo, Italy; and Clinical Effectiveness Research Group, Institute of Health (H.-O.A.), University of Oslo, Norway.

Objective: To determine whether high baseline dietary antioxidants and total nonenzymatic antioxidant capacity (NEAC) is associated with a lower risk of Parkinson disease (PD) in men and women, we prospectively studied 43,865 men and women from a large Swedish cohort.

Methods: In the Swedish National March Cohort, 43,865 men and women aged 18-94 years were followed through record linkages to National Health Registries from 1997 until 2016. Baseline dietary vitamin E, vitamin C, and beta-carotene intake, as well as NEAC, were assessed by a validated food frequency questionnaire collected at baseline. Read More

View Article and Full-Text PDF
February 2021

Long term follow-up results of deep brain stimulation of the Globus pallidus interna in pediatric patients with DYT1-positive dystonia.

Clin Neurol Neurosurg 2021 02 28;201:106449. Epub 2020 Dec 28.

Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical Sciences, Tehran, Iran; Skull Base Research Center, Five Senses Health Institute, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: Primary generalized dystonia (PGD) due to heterozygous torsin 1A (TOR1A) gene mutation (DYT1) is a childhood onset dystonia with rapid deterioration of symptoms, leading to severe disability in adolescence. Globus pallidus interna deep brain stimulation (GPi-DBS) has been shown to provide significant improvement in these cases.

Methods: This was a retrospective study of TOR1A mutation positive dystonia patients, conducted at a university hospital from 2006 to 2018. Read More

View Article and Full-Text PDF
February 2021

Overconfidence in visual perception in parkinson's disease.

Eur J Neurosci 2021 Mar 12;53(6):2027-2039. Epub 2021 Jan 12.

Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel.

Increased dependence on visual cues in Parkinson's disease (PD) can unbalance the perception-action loop, impair multisensory integration, and affect everyday function of PD patients. It is currently unknown why PD patients seem to be more reliant on their visual cues. We hypothesized that PD patients may be overconfident in the reliability (precision) of their visual cues. Read More

View Article and Full-Text PDF

Early-onset parkinsonism in PPP2R5D-related neurodevelopmental disorder.

Eur J Med Genet 2021 Jan 15;64(1):104123. Epub 2020 Dec 15.

Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg FAU, Erlangen, Germany. Electronic address:

PPP2R5D-related neurodevelopmental disorder (NDD) is a rare autosomal-dominant disease with developmental delay and mild to severe intellectual disability. So far, fewer than 30 affected individuals with mostly recurrent, de novo missense variants in PPP2R5D were reported. Recently, parkinsonism with an onset between 20 and 40 years was reported in four adult individuals with the same p. Read More

View Article and Full-Text PDF
January 2021

The Effect of Endurance Training on Brain-Derived Neurotrophic Factor and Inflammatory Markers in Healthy People and Parkinson's Disease. A Narrative Review.

Front Physiol 2020 19;11:578981. Epub 2020 Nov 19.

Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland.

One purpose of the training conducted by people is to lose bodyweight and improve their physical condition. It is well-known that endurance training provides many positive changes in the body, not only those associated with current beauty standards. It also promotes biochemical changes such as a decreased inflammatory status, memory improvements through increased brain-derived neurotrophic factor levels, and reduced stress hormone levels. Read More

View Article and Full-Text PDF
November 2020

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

Lancet 2021 01 8;397(10269):99-111. Epub 2020 Dec 8.

St George's Vaccine Institute, St George's, University of London, London, UK.

Background: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.

Methods: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Read More

View Article and Full-Text PDF
January 2021

The erythrocyte sedimentation rate in male adolescents and subsequent risk of Parkinson's disease: an observational study.

J Neurol 2021 Apr 4;268(4):1508-1516. Epub 2020 Dec 4.

School of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 454, 405 30, Gothenburg, Sweden.

Systemic inflammation may be implicated in the pathophysiology of Parkinson's disease (PD). Since PD occurs usually in later life, most studies of causal factors are conducted in older populations, so potentially important influences from early life cannot be adequately captured. We investigated whether the erythrocyte sedimentation rate (ESR) in early adulthood is associated with the subsequent development of PD in men. Read More

View Article and Full-Text PDF

Common diseases alter the physiological age-related blood microRNA profile.

Nat Commun 2020 11 24;11(1):5958. Epub 2020 Nov 24.

Chair for Clinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.

Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. Read More

View Article and Full-Text PDF
November 2020

Clinical presentation and immunological features of Post-Malaria Neurologic Syndrome: a case report and review of literature.

Malar J 2020 Nov 23;19(1):419. Epub 2020 Nov 23.

Infectious Diseases Division, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Integrata Di Udine, 33100, Udine, Italy.

Background: Malaria still represents a major health threat, in terms of both morbidity and mortality. Complications of malaria present a diversified clinical spectrum, with neurological involvement leading to the most serious related-conditions. The authors recently encountered a case of a 60-year old Italian man presenting with confusion, language disturbances and Parkinson-like syndrome 3 weeks after complete remission from severe Plasmodium falciparum cerebral malaria. Read More

View Article and Full-Text PDF
November 2020

Transitional Care for Young People with Neurological Disorders: A Scoping Review with A Focus on Patients with Movement Disorders.

Mov Disord 2021 06 17;36(6):1316-1324. Epub 2020 Nov 17.

Department of Neurology, Salpêtrière Hospital, Sorbonne University and Assistance Publique - Hôpitaux de Paris, Paris, France.

Childhood-onset movement disorders represent a heterogenous group of conditions. Given the complexity of these disorders, the transition of care from pediatric to adult medicine is an important consideration. We performed a scoping review of the literature on transitional care in chronic neurological disease, exploring key transitional issues and proposed transitional care models. Read More

View Article and Full-Text PDF

Brief Visuospatial Memory Test-Revised: normative data and clinical utility of learning indices in Parkinson's disease.

J Clin Exp Neuropsychol 2020 12 16;42(10):1099-1110. Epub 2020 Nov 16.

Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital in Prague , Prague, Czech Republic.

: The Brief Visual Memory Test-Revised (BVMT-R) is a frequently used visuospatial declarative memory test, but normative data in the Czech population are lacking. Moreover, the BVMT-R includes promising learning indexes that can be used to detect learning deficits in Parkinson's disease (PD). However, its clinical usefulness has not yet been thoroughly examined. Read More

View Article and Full-Text PDF
December 2020

A Wearable Sensor System to Measure Step-Based Gait Parameters for Parkinson's Disease Rehabilitation.

Sensors (Basel) 2020 Nov 10;20(22). Epub 2020 Nov 10.

Center for Adaptive Neural Systems, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA.

Spatiotemporal parameters of gait serve as an important biomarker to monitor gait impairments as well as to develop rehabilitation systems. In this work, we developed a computationally-efficient algorithm (SDI-Step) that uses segmented double integration to calculate step length and step time from wearable inertial measurement units (IMUs) and assessed its ability to reliably and accurately measure spatiotemporal gait parameters. Two data sets that included simultaneous measurements from wearable sensors and from a laboratory-based system were used in the assessment. Read More

View Article and Full-Text PDF
November 2020

Characterization of Recessive Parkinson Disease in a Large Multicenter Study.

Ann Neurol 2020 10 28;88(4):843-850. Epub 2020 Jul 28.

Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Studies of the phenotype and population distribution of rare genetic forms of parkinsonism are required, now that gene-targeting approaches for Parkinson disease have reached the clinical trial stage. We evaluated the frequencies of PRKN, PINK1, and DJ-1 mutations in a cohort of 1,587 cases. Mutations were found in 14. Read More

View Article and Full-Text PDF
October 2020

Reconstructing lost BOLD signal in individual participants using deep machine learning.

Nat Commun 2020 10 7;11(1):5046. Epub 2020 Oct 7.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Signal loss in blood oxygen level-dependent (BOLD) functional neuroimaging is common and can lead to misinterpretation of findings. Here, we reconstructed compromised fMRI signal using deep machine learning. We trained a model to learn principles governing BOLD activity in one dataset and reconstruct artificially compromised regions in an independent dataset, frame by frame. Read More

View Article and Full-Text PDF
October 2020

A case report of delayed diagnosis of danon disease: Caused by a newly recognized mutation in the lysosome-associated membrane protein-2 gene.

Medicine (Baltimore) 2020 Oct;99(40):e22640

The Center of Cardiovascular Diseases, The First Hospital of Jilin University, Changchun, China.

Introduction: Danon disease is a rare X-linked dominant genetic disorder caused by defects in the lysosome-associated membrane protein 2 (LAMP2) gene. Unless treated, cardiogenic death is the main cause of mortality. This case report describes a 19-year-old man who was diagnosed with Danon disease and survived for 3 years from symptom onset to death. Read More

View Article and Full-Text PDF
October 2020

Relationship between tongue pressure and functional oral intake scale diet type in patients with neurological and neuromuscular disorders.

Clin Neurol Neurosurg 2020 11 13;198:106196. Epub 2020 Sep 13.

Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Introduction: Patients with neurological and neuromuscular disorders (NNMD) frequently experience swallowing disorders that increase aspiration pneumonia risk and therefore require specialized diets or tube feeding. Diet type level usually is assessed by video fluoroscopic swallowing study (VFSS). To identify a simpler assessment method, we examined the association between diet type (based on the Functional Oral Intake Scale [FOIS]) diet type and maximum tongue pressure (MTP). Read More

View Article and Full-Text PDF
November 2020

Sodium, Potassium, Calcium, and Magnesium in the Scalp Hair and Blood Samples Related to the Clinical Stages of the Parkinson's Disease.

Biol Trace Elem Res 2021 Jul 22;199(7):2582-2589. Epub 2020 Sep 22.

National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.

Neurodegeneration disorders are complex and multifaceted, leading to many chronic diseases, like Parkinson's disease (PD). Electrolytes imbalance has a significant role in the pathophysiology of neurological disorders, which might serve as a bio-indicator of these problems. In the present study, the disturbances of the electrolytes, calcium (Ca), magnesium (Mg), sodium (Na), and potassium (K), concentrations, and their correlation with biochemical parameters of PD patients at three different age groups (15 to 75 years) and stages were studied. Read More

View Article and Full-Text PDF

Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer's and Parkinson's Diseases in Young Urbanites Exposed to Air Pollution.

J Alzheimers Dis 2020 ;78(2):479-503

Pathology Consultant, Mexico City, Mexico.

Alzheimer's and Parkinson's diseases (AD, PD) have a pediatric and young adult onset in Metropolitan Mexico City (MMC). The SARS-CoV-2 neurotropic RNA virus is triggering neurological complications and deep concern regarding acceleration of neuroinflammatory and neurodegenerative processes already in progress. This review, based on our MMC experience, will discuss two major issues: 1) why residents chronically exposed to air pollution are likely to be more susceptible to SARS-CoV-2 systemic and brain effects and 2) why young people with AD and PD already in progress will accelerate neurodegenerative processes. Read More

View Article and Full-Text PDF
November 2020

The Effect of the COVID-19 Pandemic on People with Parkinson's Disease.

J Parkinsons Dis 2020 ;10(4):1365-1377

Department of Neurology, Weill Institute for the Neurosciences, University of California San Francisco, & San Francisco VA Health Care System, San Francisco, CA, USA.

Background: The effect of the COVID-19 pandemic on people with Parkinson's disease (PD) is poorly understood.

Objective: To rapidly identify areas of need and improve care in people with PD during the COVID-19 pandemic, we deployed a survey to assess COVID-19 symptoms and the pandemic's effect among those with and without COVID-19.

Methods: People with and without PD participating in the online study Fox Insight (FI) were invited to complete a survey between April 23 and May 23, 2020. Read More

View Article and Full-Text PDF
November 2020

Ganglion Cell Complex Thinning in Young Gaucher Patients: Relation to Prodromal Parkinsonian Markers.

Mov Disord 2020 12 12;35(12):2211-2219. Epub 2020 Sep 12.

Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Patients with Gaucher disease (GD) have an increased risk for parkinsonism. Retinal thinning has been described in parkinsonism as an early nonmotor feature. Scarce reports have addressed retinal thickness changes in GD. Read More

View Article and Full-Text PDF
December 2020

Effect of a Concurrent Cognitive Task, with Stabilizing Visual Information and Withdrawal, on Body Sway Adaptation of Parkinsonian's Patients in an Off-Medication State: A Controlled Study.

Sensors (Basel) 2020 Sep 6;20(18). Epub 2020 Sep 6.

ProtoKinetics, Havertown, PA 19083, USA.

: In persons with Parkinson's disease (pwPD) any additional somatosensory or distractor interference can influence the posture. When deprivation of vision and dual-task are associated, the effect on biomechanical performance is less consistent. The aim of this study was to evaluate the role of the visual deprivation and a cognitive task on the static balance in earlier stage PD subjects. Read More

View Article and Full-Text PDF
September 2020

Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal.

Environ Res 2020 12 2;191:110139. Epub 2020 Sep 2.

Centre for Environmental Magnetism and Paleomagnetism, Lancaster Environment Centre, University of Lancaster, Lancaster, LA1 4YQ, UK.

Fine particulate air pollution (PM) exposures are linked with Alzheimer's and Parkinson's diseases (AD,PD). AD and PD neuropathological hallmarks are documented in children and young adults exposed lifelong to Metropolitan Mexico City air pollution; together with high frontal metal concentrations (especially iron)-rich nanoparticles (NP), matching air pollution combustion- and friction-derived particles. Here, we identify aberrant hyperphosphorylated tau, ɑ synuclein and TDP-43 in the brainstem of 186 Mexico City 27. Read More

View Article and Full-Text PDF
December 2020