1,372 results match your criteria Parkinson Disease in Young Adults


Quantifying Dynamic Balance in Young, Elderly and Parkinson's Individuals: A Systematic Review.

Front Aging Neurosci 2018 22;10:387. Epub 2018 Nov 22.

School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.

Falling is one of the primary concerns for people with Parkinson's Disease and occurs predominately during dynamic movements, such as walking. Several methods have been proposed to quantify dynamic balance and to assess fall risk. However, no consensus has been reached concerning which method is most appropriate for examining walking balance during unperturbed and perturbed conditions, particularly in Parkinson's Disease individuals. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262057PMC
November 2018

Non-motor Symptoms in Patients with Parkinson's Disease: A Cross-sectional Survey.

Cureus 2018 Oct 4;10(10):e3412. Epub 2018 Oct 4.

Neurology, Shifa International Hospital, Islamabad, PAK.

Background In multiple studies around the globe, non-motor symptoms (NMS) have been identified as a source of immense disability in patients with Parkinson's disease (PD). However, there is a scarcity of data from Asia. This is the first study of the Pakistani population to assess the impact of NMS in PD on patients. Read More

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http://dx.doi.org/10.7759/cureus.3412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281445PMC
October 2018
1 Read

Visual detection of affordances for aperture negotiation in people with Parkinson disease.

Neuropsychologia 2018 Nov 18;120:59-64. Epub 2018 Oct 18.

First Physical Therapy, United States.

Background: An essential requirement for the guidance of action in cluttered environments is that people can accurately perceive what actions are afforded by particular surroundings given the person's action capabilities. Research has shown that healthy young individuals turn their shoulders when walking through a doorway when the aperture is less than a certain percentage of their shoulder width and that they are able to detect this critical width with visual inspection. These findings imply that movements are constrained by perception of the environment in body-scaled unit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283932183071
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http://dx.doi.org/10.1016/j.neuropsychologia.2018.10.010DOI Listing
November 2018
10 Reads

"You can tell by the way I use my walk." Predicting the presence of cognitive load with gait measurements.

Biomed Eng Online 2018 Sep 12;17(1):122. Epub 2018 Sep 12.

Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.

Background: There is considerable evidence that a person's gait is affected by cognitive load. Research in this field has implications for understanding the relationship between motor control and neurological conditions in aging and clinical populations. Accordingly, this pilot study evaluates the cognitive load based on gait accelerometry measurements of the walking patterns of ten healthy individuals (18-35 years old). Read More

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http://dx.doi.org/10.1186/s12938-018-0555-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134780PMC
September 2018

A Novel SYNJ1 Mutation in a Tunisian Family with Juvenile Parkinson's Disease Associated with Epilepsy.

J Mol Neurosci 2018 Oct 5;66(2):273-278. Epub 2018 Sep 5.

Laboratoire de Recherche en Neurogénétique, Maladie de Parkinson et Maladies Cérébro-Vasculaires (LR-12-SP-19), Habib Bourguiba University Hospital, 3029, Sfax, Tunisia.

Mutations in SYNJ1 gene have been described in few families with juvenile atypical Parkinson disease (PD). This gene encodes for "Synaptojanin 1," an enzyme playing a major role in the phosphorylation and the recycling of synaptic vesicles. In this study, we report two siblings, from a consanguineous Tunisian family, presenting juvenile PD. Read More

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http://dx.doi.org/10.1007/s12031-018-1167-2DOI Listing
October 2018
6 Reads

Is transcranial sonography useful for diagnosing Parkinson's disease in clinical practice?

Arq Neuropsiquiatr 2018 Jul;76(7):459-466

Universidade de Brasília, Faculdade de Medicina, Brasília DF, Brasil.

Objective: Transcranial sonography (TCS) is an emerging ancillary examination for diagnosing Parkinson's disease (PD).

Objective: To evaluate TCS features in patients with PD and its mimics, and establish their accuracy in predicting the final clinical diagnosis after follow-up.

Methods: We retrospectively studied 85 patients with an initial clinical suspicion of PD, atypical parkinsonism or essential tremor, all of whom underwent TCS. Read More

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http://dx.doi.org/10.1590/0004-282X20180067DOI Listing
July 2018
6 Reads

Novel biomarker for neurodegenerative diseases- motor neuron disease (MND), cerebellar ataxia (CA) and Parkinson's disease (PD).

Clin Chim Acta 2018 Oct 10;485:258-261. Epub 2018 Jul 10.

Department of Biochemistry, KGMU, Lucknow 226003, UP, India.

Oxygen is the most mandatory component of living organism and it may at times produce highly reactive species, the free radicals, which are destructive to normal living tissues. Degenerative diseases of central nervous system (CNS) are quite common, contributing significantly to morbidity as well as mortality %. In neurodegenerative diseases such as motor neuron disease (MND), Cerebellar Ataxia (CA) and Parkinson's disease (PD), there is no direct evidence for involvement of metals and free radicals in the etiology but circumstantial evidence provides a hypothesis that alteration in metals and free radicals contribute to the pathogenesis of neurodegeneration in these disorders. Read More

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http://dx.doi.org/10.1016/j.cca.2018.07.021DOI Listing
October 2018
8 Reads
2.824 Impact Factor

Categorization system-switching deficits in typical aging and Parkinson's disease.

Neuropsychology 2018 Sep 28;32(6):724-734. Epub 2018 Jun 28.

Department of Psychological Sciences, Purdue University.

Objective: Numerous studies documenting cognitive deficits in Parkinson's disease (PD) revealed impairment in a variety of tasks related to memory, learning, and attention. One ubiquitous task that has not received much attention, is categorization system-switching. Categorization system-switching is a form of task-switching requiring participants to switch between different categorization systems. Read More

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http://dx.doi.org/10.1037/neu0000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126963PMC
September 2018

GCH1 mutations in dopa-responsive dystonia and Parkinson's disease.

J Neurol 2018 Aug 14;265(8):1860-1870. Epub 2018 Jun 14.

Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Guanosine triphosphate cyclohydrolase I (GCH1) mutations are associated with increased risk for dopa-responsive dystonia (DRD) and Parkinson's disease (PD). Herein, we investigated the frequency of GCH1 mutations and clinical symptoms in patients with clinically diagnosed PD and DRD. We used the Sanger method to screen entire exons in 268 patients with PD and 26 patients with DRD, with the examinations of brain magnetic resonance imaging scans, striatal dopamine transporter scans, and [I] metaiodobenzylguanidine (MIBG) myocardiac scintigraphy scans. Read More

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http://dx.doi.org/10.1007/s00415-018-8930-8DOI Listing
August 2018
4 Reads

Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway.

Mol Cell Proteomics 2018 Sep 18;17(9):1778-1787. Epub 2018 Jun 18.

From the ‡Department of Molecular and Translational Medicine, Center for Biomedical Mass Spectrometry, Boston University Medical Campus, Boston, Massachusetts;

Parkinson's disease (PD) is a neurological disorder characterized by the progressive loss of functional dopaminergic neurons in the nigrostriatal pathway in the brain. Although current treatments provide only symptomatic relief, gene therapy has the potential to slow or halt the degeneration of nigrostriatal dopamine neurons in PD patients. Adeno-associated viruses (AAV) are vectors of choice in gene therapy because of their well-characterized safety and efficacy profiles; however, although gene therapy has been successful in preclinical models of the disease, clinical trials in humans have failed to demonstrate efficacy. Read More

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http://dx.doi.org/10.1074/mcp.RA118.000680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126385PMC
September 2018
8 Reads

Long-Term Effect of Modified Incision to Prevent Related Complications in Deep Brain Stimulation.

World Neurosurg 2018 Sep 7;117:280-283. Epub 2018 Jun 7.

Department of Neurosurgery, Tsinghua University Yuquan Hospital, Shijingshan District, Beijing, China. Electronic address:

Background: Skin complications are a frequent type of complication of deep brain stimulation (DBS) neurosurgical procedure and are always observed in the postauricular area, scalp area, and implantable pulse generator pocket. Modifications to the surgical techniques for DBS have been proposed as therapeutic options. To prevent skin complications, we modified the surgical incisions. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.05.224DOI Listing
September 2018
8 Reads

Age affects reinforcement learning through dopamine-based learning imbalance and high decision noise-not through Parkinsonian mechanisms.

Neurobiol Aging 2018 08 19;68:102-113. Epub 2018 Apr 19.

Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, Newark, NJ, USA. Electronic address:

Probabilistic reinforcement learning declines in healthy cognitive aging. While some findings suggest impairments are especially conspicuous in learning from rewards, resembling deficits in Parkinson's disease, others also show impairments in learning from punishments. To reconcile these findings, we tested 252 adults from 3 age groups on a probabilistic reinforcement learning task, analyzed trial-by-trial performance with a Q-reinforcement learning model, and correlated both fitted model parameters and behavior to polymorphisms in dopamine-related genes. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993631PMC
August 2018
1 Read

Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2.

Neurology 2018 Jun 11;90(23):e2059-e2067. Epub 2018 May 11.

From The Dalglish Family 22q Clinic for Adults and Department of Psychiatry (E.B., A.M.F., A.S.B.), Toronto General Research Institute (A.S.B.), and Division of Cardiology, Department of Medicine (A.S.B.), University Health Network, Toronto, Canada; De Hartekamp Groep (E.B.), Centre for People with Intellectual Disability, Haarlem; Department of Nuclear Medicine (E.B., J.B.), Academic Medical Center, Amsterdam, the Netherlands; Clinical Genetics Research Program and Campbell Family Mental Health Research Institute (N.J.B., A.M.F., A.S.B.), Centre for Addiction and Mental Health, Toronto; Institute of Medical Science (N.J.B., M.M., A.E.L., A.S.B.), Division of Neurology, Department of Medicine (C.M., M.M., A.E.L.), and Department of Psychiatry (A.S.B.), University of Toronto; Deer Lodge Movement Disorders Centre (S.U.); Section of Neurology (S.U.), Division of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg; Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease Research (C.M., A.E.L.), Toronto Western Hospital and University of Toronto, Canada; Department of Molecular Neuroscience (K.Y.M., N.W.W.), UCL Institute of Neurology, London, UK; Department of Neurology (S.K.), Kansai Medical University, Osaka, Japan; Department of Neurology (M.J.B.), University of Virginia School of Medicine, Charlottesville; Medical Genetics Unit (P.P.), Perugia University Hospital, Italy; Department of Neurology (B.D.B.), University of Colorado Anschutz Medical Campus, Aurora; Neurology Section (B.D.B.), VA Eastern Colorado Health Care System, Denver; Cognitive & Movement Disorders Clinic and Hurvitz Brain Sciences Research Program (M.M.), Sunnybrook Health Sciences Centre, Toronto, Canada; Departments of Clinical Neurosciences (Movement Disorders) (B.D.) and Genetics (Neurogenetics) (K.N.), Timone University Hospital (AP-HM), Provence-Alpes-Côte d'Azur; Aix-Marseille University (B.D., K.N.), Marseille; Department of Genetics (Neurogenetics) (P.C., A.J.), Pitié-Salpêtrière University Hospital; Sorbonne University (P.C., A.J.), Paris; Department of Neurosciences (Movement Disorders) (E.M.), Lille University Hospital; Lille University (E.M.); Department of Neurology (Movement Disorders) (T.D.), Pierre Wertheimer University Hospital, Lyon; Marc Jeannerod Center for Cognitive Neurosciences (T.D.), Lyon-1 University; Department of Neurology (Movement Disorders) and Clinical Investigation Center (Clinical and Experimental Neurosciences) (O.C.), Poitiers University Hospital; Department of Neurology (Movement Disorders) (S.D.), Rennes University Hospital; Rennes-1 University (S.D.); Department of Clinical Neurosciences (Movement Disorders) (M.B.), Nice University Hospital, France; Department of Psychiatry (A.M.F.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands; Center for Human Genetics (E.V., A.S., A.V.), University Hospital Leuven; Department of Human Genetics (A.S.), KU Leuven, Belgium; Department of Neurology (A.P.), University of Munich, Germany; Scientific and Technological Coordination Unit of the ANLIS Directorate (C.P.), National Administration of Laboratories and Institutes of Health, Argentina; Department of Neurodegenerative Diseases (T.G.), Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.); Department of Neurology (K.C.), AZ Turnhout, Antwerp, Belgium; Neurology Unit and Stroke Center (F.B.), Hôpital Foch, Suresnes, France; Movement Disorder Division (K.M.), Johns Hopkins University, Baltimore, MD; and Psychological Medicine and Clinical Neurosciences (N.M.W.), MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff University, UK.

Objective: To delineate the natural history, diagnosis, and treatment response of Parkinson disease (PD) in individuals with 22q11.2 deletion syndrome (22q11.2DS), and to determine if these patients differ from those with idiopathic PD. Read More

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http://dx.doi.org/10.1212/WNL.0000000000005660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993183PMC
June 2018
4 Reads

Tubulin and Tau: Possible targets for diagnosis of Parkinson's and Alzheimer's diseases.

PLoS One 2018 9;13(5):e0196436. Epub 2018 May 9.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

Neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by progressive neuronal loss and pathological accumulation of some proteins. Developing new biomarkers for both diseases is highly important for the early diagnosis and possible development of neuro-protective strategies. Serum antibodies (AIAs) against neuronal proteins are potential biomarkers for AD and PD that may be formed in response to their release into systemic circulation after brain damage. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942772PMC
August 2018
7 Reads

Outcomes of Ebstein's Anomaly Patients Treated with Tricuspid Valvuloplasty or Tricuspid Valve Replacement: Experience of a Single Center.

Chin Med J (Engl) 2018 May;131(9):1067-1074

Department of Cardiac Surgery, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.

Background: The incidence of Ebstein's anomaly is extremely low, and except for the Mayo Clinic, no cardiac center has reported on a sufficient number of patients. The aim of our study was to report the outcomes of Ebstein's anomaly patients treated with tricuspid valvuloplasty (TVP) or tricuspid valve replacement (TVR).

Methods: TVP or TVR was performed in 245 patients from July 2006 to April 2016. Read More

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http://dx.doi.org/10.4103/0366-6999.230731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937315PMC
May 2018
6 Reads

Identification of clinically relevant phenotypes in patients with Ebstein anomaly.

Clin Cardiol 2018 Mar 22;41(3):343-348. Epub 2018 Mar 22.

Departamento de Investigaciones, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.

Background: Ebstein anomaly (EA) is a heterogeneous congenital heart defect (CHD), frequently accompanied by diverse cardiac and extracardiac comorbidities, resulting in a wide range of clinical outcomes.

Hypothesis: Phenotypic characterization of EA patients has the potential to identify variables that influence prognosis and subgroups with distinct contributing factors.

Methods: A comprehensive cross-sectional phenotypic characterization of 147 EA patients from one of the main referral institutions for CHD in Colombia was carried out. Read More

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http://dx.doi.org/10.1002/clc.22870DOI Listing
March 2018
6 Reads

Iatrogenic Ventricular Fibrillation after Direct-Current Cardioversion of Preexcited Atrial Fibrillation Caused by Inadvertent T-Wave Synchronization.

Tex Heart Inst J 2018 02 1;45(1):39-41. Epub 2018 Feb 1.

Direct-current cardioversion is an important means of managing arrhythmias. During treatment, carefully synchronizing energy delivery to the QRS complex is necessary to avoid ventricular fibrillation caused by a shock during the vulnerable period of ventricular repolarization, that is, a shock on the T wave. The presence of an accessory pathway and ventricular preexcitation can lead to difficulty in distinguishing the QRS complex from the T wave because of bizarre, wide, irregular QRS complexes and prominent repolarization. Read More

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http://dx.doi.org/10.14503/THIJ-16-6162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832085PMC
February 2018
5 Reads

Thalamocortical dysrhythmia detected by machine learning.

Nat Commun 2018 03 16;9(1):1103. Epub 2018 Mar 16.

Unit of Neurosurgery, Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, 9054, New Zealand.

Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological disorders. It is characterized by a common oscillatory pattern in which resting-state alpha activity is replaced by cross-frequency coupling of low- and high-frequency oscillations. We undertook a data-driven approach using support vector machine learning for analyzing resting-state electroencephalography oscillatory patterns in patients with Parkinson's disease, neuropathic pain, tinnitus, and depression. Read More

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http://dx.doi.org/10.1038/s41467-018-02820-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856824PMC
March 2018
3 Reads

Effects of 99mTc-TRODAT-1 drug template on image quantitative analysis.

PLoS One 2018 15;13(3):e0194503. Epub 2018 Mar 15.

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.

99mTc-TRODAT-1 is a type of drug that can bind to dopamine transporters in living organisms and is often used in SPCT imaging for observation of changes in the activity uptake of dopamine in the striatum. Therefore, it is currently widely used in studies on clinical diagnosis of Parkinson's disease (PD) and movement-related disorders. In conventional 99mTc-TRODAT-1 SPECT image evaluation, visual inspection or manual selection of ROI for semiquantitative analysis is mainly used to observe and evaluate the degree of striatal defects. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854413PMC
July 2018
3 Reads

Prevalence of Helicobacter pylori among Alaskans: Factors associated with infection and comparison of urea breath test and anti-Helicobacter pylori IgG antibodies.

Helicobacter 2018 Jun 14;23(3):e12482. Epub 2018 Mar 14.

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA.

Background: Helicobacter pylori is one of the most common human infections in the world, and studies in Alaska Native people, as well as other Indigenous peoples, have shown a high prevalence of this gastric infection. This study was undertaken to determine the prevalence of H. pylori infection by urea breath test (UBT) and anti- H. Read More

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http://dx.doi.org/10.1111/hel.12482DOI Listing
June 2018
4 Reads

Direct localisation of the human pedunculopontine nucleus using MRI: a coordinate and fibre-tracking study.

Eur Radiol 2018 Sep 12;28(9):3882-3892. Epub 2018 Mar 12.

State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China.

Objectives: To image the pedunculopontine tegmental nucleus (PPN), a deep brain stimulation (DBS) target for Parkinson disease, using MRI with validated results.

Methods: This study used the MP2RAGE sequence with high resolution and enhanced grey-white matter contrast on a 7-T ultra-high-field MRI system to image the PPN as well as a diffusion spectrum imaging method on a 3-T MRI system to reconstruct the main fibre systems surrounding the PPN. The coordinates of the rostral and caudal PPN poles of both sides were measured in relation to the third and fourth ventricular landmarks on the 7-T image. Read More

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http://dx.doi.org/10.1007/s00330-017-5299-5DOI Listing
September 2018
13 Reads
4.014 Impact Factor

Influence of Music Style and Rate on Repetitive Finger Tapping.

Motor Control 2018 Oct 9;22(4):472-485. Epub 2018 Mar 9.

1 Iowa State University.

Auditory cues, including music, are commonly used in the treatment of persons with Parkinson's disease. Yet, how music style and movement rate modulate movement performance in persons with Parkinson's disease have been neglected and remain limited in healthy young populations. The purpose of this study was to determine how music style and movement rate influence movement performance in healthy young adults. Read More

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http://dx.doi.org/10.1123/mc.2017-0081DOI Listing
October 2018
1 Read

Effect of virtual reality in Parkinson's disease: a prospective observational study.

Arq Neuropsiquiatr 2018 Feb;76(2):78-84

Universidade Tuiuti do Paraná, Departamento de Otoneurologia, Curitiba PR, Brasil.

Objective: To assess the effectiveness of balance exercises by means of virtual reality games in Parkinson's disease.

Methods: Sixteen patients were submitted to anamnesis, otorhinolaryngological and vestibular examinations, as well as the Dizziness Handicap Inventory, Berg Balance Scale, SF-36 questionnaire, and the SRT, applied before and after rehabilitation with virtual reality games.

Results: Final scoring for the Dizziness Handicap Inventory and Berg Balance Scale was better after rehabilitation. Read More

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http://dx.doi.org/10.1590/0004-282X20170195DOI Listing
February 2018

Clinical characteristics and quality of life in Chinese patients with Parkinson's disease beyond 20 years.

Neurol Res 2018 Apr 15;40(4):312-317. Epub 2018 Feb 15.

a Department of Neurology , West China Hospital, Sichuan University , Chengdu , China.

Background The number of Parkinson's disease (PD) patients with disease duration of more than 20 years (long disease duration PD, LPD) is on the rise. Objectives This study aims to describe the clinical profiles and the quality of life (QoL) of LPD patients from a cohort of the Chinese population. Methods We compared 71 LPD subjects to 60 PD patients who died less than 20 years after the onset of PD (control PD, CPD). Read More

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http://dx.doi.org/10.1080/01616412.2018.1438227DOI Listing
April 2018
2 Reads

The epidemiology of Parkinson's disease in the Italian region Friuli Venezia Giulia: a population-based study with administrative data.

Neurol Sci 2018 Apr 9;39(4):699-704. Epub 2018 Feb 9.

Neurology Unit, Neuroscience Department, "S. Maria della Misericordia" University Hospital of Udine, Udine, Italy.

Parkinson's disease is known to pose a relevant burden to society in industrialized countries. However, not much research has been conducted on the epidemiology of this disease in Italy. Our aim was to estimate the incidence rate and prevalence of Parkinson's disease in the Italian Friuli Venezia Giulia region using administrative health-related databases. Read More

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http://dx.doi.org/10.1007/s10072-018-3273-xDOI Listing

How many strides are required for a reliable estimation of temporal gait parameters? Implementation of a new algorithm on the phase coordination index.

PLoS One 2018 8;13(2):e0192049. Epub 2018 Feb 8.

Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel.

Background: The Phase coordination index (PCI), a temporal gait measure that quantifies consistency and accuracy in generating the anti-phased left-right stepping pattern, assesses bilateral coordination of gait in various cohorts (e.g., Parkinson's disease, post stroke). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192049PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805232PMC

Assessment of Snaith-Hamilton Pleasure Scale (SHAPS): the dimension of anhedonia in Italian healthy sample.

Neurol Sci 2018 Apr 30;39(4):657-661. Epub 2018 Jan 30.

National Research Council (IBFM-CNR), Institute of Molecular Bioimaging and Physiology, Viale Europa, 88100, Catanzaro, Italy.

The Snaith-Hamilton Pleasure Scale (SHAPS) is a rapid screening battery created for assessing the presence of anhedonia, namely the inability to experience pleasure. Although, this symptom has widely been investigated in clinical settings, individual differences in anhedonia are also present in healthy population. The aim of present study was to validate the translated Italian version of this test. Read More

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http://dx.doi.org/10.1007/s10072-018-3260-2DOI Listing
April 2018
1 Read

A Common Function of Basal Ganglia-Cortical Circuits Subserving Speed in Both Motor and Cognitive Domains.

eNeuro 2017 Nov-Dec;4(6). Epub 2017 Dec 8.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Distinct regions of the frontal cortex connect with their basal ganglia and thalamic counterparts, constituting largely segregated basal ganglia-thalamo-cortical (BTC) circuits. However, any common role of the BTC circuits in different behavioral domains remains unclear. Indeed, whether dysfunctional motor and cognitive BTC circuits are responsible for motor slowing and cognitive slowing, respectively, in Parkinson's disease (PD) is a matter of debate. Read More

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http://dx.doi.org/10.1523/ENEURO.0200-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783269PMC
December 2018
2 Reads

Slower saccadic reading in Parkinson's disease.

PLoS One 2018 24;13(1):e0191005. Epub 2018 Jan 24.

Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, United States of America.

Idiopathic Parkinson's Disease (PD) is characterized by degeneration of dopaminergic and other neurons, leading to motor and non-motor deficits. Abnormal eye movements in PD, including fixations, saccades, and convergence, are well described. However, saccadic reading, which requires serial and alternating saccades and fixations, is not well studied, despite its obvious impact on the quality of life. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783375PMC
February 2018
3 Reads

Paroxysmal Nocturnal Hemoglobinuria (Pnh): Brain Mri Ischemic Lesions In Neurologically Asymtomatic Patients.

Sci Rep 2018 01 11;8(1):476. Epub 2018 Jan 11.

Hematology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

This study investigated for the first time brain ischemic involvement in 19 consecutive neurologically asymptomatic PNH patients by non-enhanced cerebral MRI, and by intracranial arterial and venous angio-MRI. Eleven cases (58%, 7 aged <65) showed pathological findings: 9 white matter (WM) abnormalities related to chronic ischemic small vessel disease, 2 a focal abnormality >5 mm, and 5 cases a score >4 by the age-related white matter changes (ARWMC) scale. Compared with age and sex-matched controls (1:2 ratio), patients showed an increased frequency of periventricular WM vascular degeneration (32% versus 5. Read More

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http://dx.doi.org/10.1038/s41598-017-18936-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765159PMC
January 2018
45 Reads

Cardiac manifestations of PRKAG2 mutation.

BMC Med Genet 2018 01 3;19(1). Epub 2018 Jan 3.

Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine at UCLA, 675 Charles E Young Dr. S. Room 3760, Los Angeles, CA, 90095, USA.

Background: The Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2 (PRKAG2) cardiac syndrome is characterized by glycogen accumulation in the cardiac tissue. The disease presents clinically with hypertrophic cardiomyopathy (HCM), and it is often associated with conduction abnormalities.

Case Presentation: A 23 year-old female with history of Wolff-Parkinson-White (WPW) and HCM presented for evaluation after an episode of Non-ST Elevation Myocardial Infarction (NSTEMI). Read More

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http://dx.doi.org/10.1186/s12881-017-0512-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751825PMC
January 2018
3 Reads

Navigating Interprofessional Spaces: Experiences of Clients Living with Parkinson's Disease, Students and Clinical Educators.

J Interprof Care 2018 May 21;32(3):304-312. Epub 2017 Dec 21.

c School of Interprofessional Health Studies , Auckland University of Technology , Auckland , New Zealand.

When students in interprofessional education and practice programmes partner with clients living with a long-term condition, the potential for a better client and educational experience is enhanced when the focus is on client self-management and empowerment. This paper reports the findings from a phenomenological study into the experiences of five clients, six speech language therapy students, eight physiotherapy students, and two clinical educators participating in a university clinic-based interprofessional programme for clients living in the community with Parkinson's Disease. Collaborative hermeneutic analysis was conducted to interpret the texts from client interviews and student and clinical educator focus groups held immediately after the programme. Read More

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http://dx.doi.org/10.1080/13561820.2017.1417238DOI Listing

Longevity of Implantable Pulse Generators in Bilateral Deep Brain Stimulation for Movement Disorders.

Neuromodulation 2018 Aug 19;21(6):597-603. Epub 2017 Dec 19.

Department of Neurosurgery, Charité University Medicine Berlin, Berlin, Germany.

Background: Deep brain stimulation (DBS) is a well-established therapy for otherwise intractable movement disorders. Thus far, most patients receive nonrechargeable implantable pulse generators (IPG). Eventually, another intervention to replace the IPG is inevitable. Read More

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http://dx.doi.org/10.1111/ner.12743DOI Listing
August 2018
2 Reads

Decoding of Human Movements Based on Deep Brain Local Field Potentials Using Ensemble Neural Networks.

Comput Intell Neurosci 2017 19;2017:5151895. Epub 2017 Oct 19.

Department of Electrical and Computer Engineering, Florida International University, Miami, FL 33174, USA.

Decoding neural activities related to voluntary and involuntary movements is fundamental to understanding human brain motor circuits and neuromotor disorders and can lead to the development of neuromotor prosthetic devices for neurorehabilitation. This study explores using recorded deep brain local field potentials (LFPs) for robust movement decoding of Parkinson's disease (PD) and Dystonia patients. The LFP data from voluntary movement activities such as left and right hand index finger clicking were recorded from patients who underwent surgeries for implantation of deep brain stimulation electrodes. Read More

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http://dx.doi.org/10.1155/2017/5151895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672124PMC
August 2018
7 Reads

Enteric Pathologic Manifestations of Alpha-Synucleinopathies.

Appl Immunohistochem Mol Morphol 2017 Nov 20. Epub 2017 Nov 20.

Department of Pathology.

Background: Gastrointestinal (GI) symptoms are common in Parkinson disease (PD), often preceding neurological manifestations; however, early diagnostic utility of GI biopsies remains controversial. Studies suggest aberrant deposition of alpha-synuclein (α-syn) follows step-wise progression in central nervous system though histologic interpretation of normal and aberrant staining patterns have shown variable results. This study examines whether GI α-syn mRNA expression combined with standard α-syn immunohistochemical staining enhance the role of GI biopsy in PD. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000613DOI Listing
November 2017
29 Reads

Investigating ioflupane I injection and single photon emission tomography as an imaging biomarker for long-term sequelae following mild traumatic brain injury.

Brain Inj 2018 13;32(1):105-112. Epub 2017 Nov 13.

a Department of Neurology , NorthShore University HealthSystem , Evanston , IL , USA.

Objective: To determine whether there were differences in clinical outcomes for ioflupane I injection (DaTscan) and single photon emission tomography consistent with early Parkinson's disease (PD) among individuals with a history of mild traumatic brain injury (mTBI).

Methods: We performed a case-control study among patients presenting to the Emergency Room (ER) during 2006-2013 with mTBI (cases, n = 34) or without mTBI (controls, n = 33). We performed clinical and imaging measurements in cases and controls at least 1-year post-presentation to the ER (average three years four months). Read More

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http://dx.doi.org/10.1080/02699052.2017.1388443DOI Listing
July 2018
5 Reads

Understanding uncertainty in young-onset Parkinson disease.

Chronic Illn 2017 12 20;13(4):288-298. Epub 2017 Feb 20.

1 School of Occupational Therapy, Elborn College, Western University, London, ON, Canada.

Objectives Individuals living with young-onset Parkinson's disease compose a rare subtype of a disease typically associated with older age. Situated within a large grounded theory study exploring information behavior, this paper describes the core category of the theory, i.e. Read More

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http://dx.doi.org/10.1177/1742395317694699DOI Listing
December 2017
1 Read

Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis.

Mult Scler Relat Disord 2017 Nov 20;18:65-70. Epub 2017 Sep 20.

Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth II Medical Centre, Perth, Australia; Institute of Immunology and Infectious Diseases, Murdoch University, Perth, Australia. Electronic address:

Background: Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown.

Methods: We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Read More

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http://dx.doi.org/10.1016/j.msard.2017.09.021DOI Listing
November 2017
17 Reads

Eye movements in genetic parkinsonisms affecting the α-synuclein, PARK9, and manganese network.

Clin Neurophysiol 2017 12 7;128(12):2450-2453. Epub 2017 Oct 7.

Eye Tracking and Visual Application Lab (EVALab), Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1016/j.clinph.2017.09.107DOI Listing
December 2017
2 Reads

Cognitive impairment in Glucocerebrosidase (GBA)-associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles.

Mov Disord 2017 Dec 2;32(12):1780-1783. Epub 2017 Nov 2.

Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.

Background: A proportion of idiopathic Parkinson's disease patients (PD ) with dementia show altered CSF profiles of amyloid β (Aβ) and Tau. PD patients with Glucocerebrosidase (GBA) mutations (PD ) present with even more cognitive decline than seen in PD .

Objective: The objective of this study was to evaluate whether CSF profiles of Aβ and tau are associated with the prominent cognitive impairment in PD . Read More

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http://doi.wiley.com/10.1002/mds.27199
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http://dx.doi.org/10.1002/mds.27199DOI Listing
December 2017
17 Reads

Structural abnormality of substantia nigra induced by methamphetamine abuse.

Mov Disord 2017 Dec 30;32(12):1784-1788. Epub 2017 Oct 30.

Department of Neurology, University of Leipzig, Leipzig, Germany.

Background: Methamphetamine abuse has been linked to an increased risk of Parkinson's disease.

Objective: The objective of this study was to investigate structural abnormality of the substantia nigra in past methamphetamine users using transcranial sonography.

Methods: In a cross-sectional, observational study, echogenicity of the substantia nigra was assessed in 59 past methamphetamine users and 59 matched controls. Read More

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http://dx.doi.org/10.1002/mds.27205DOI Listing
December 2017
6 Reads

Gait bradykinesia in Parkinson's disease: a change in the motor program which controls the synergy of gait.

Exp Brain Res 2018 01 27;236(1):43-57. Epub 2017 Oct 27.

Department of Neurology, School of Medicine, Shinshu University, Matsumoto, Japan.

This study examined how gait bradykinesia is changed by the motor programming in Parkinson's disease. Thirty-five idiopathic Parkinson's disease patients and nine age-matched healthy subjects participated in this study. After the patients fixated on a visual-fixation target (conditioning-stimulus), the voluntary-gait was triggered by a visual on-stimulus. Read More

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http://dx.doi.org/10.1007/s00221-017-5106-1DOI Listing
January 2018
1 Read

TLR4 and TLR2 activation is differentially associated with age during Parkinson's disease.

Immunol Invest 2018 Jan 27;47(1):71-88. Epub 2017 Oct 27.

a Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás , Goiânia , Goiás , Brazil.

Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by loss of dopaminergic neurons associated with neuroinflammation. Toll-like receptors (TLRs) are expressed in peripheral blood leukocytes and also in neurons and glial cells mediating inflammation. This study aimed to investigate the peripheral blood leukocyte response to TLR2 and TLR4 agonists in young and elderly PD patients. Read More

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http://dx.doi.org/10.1080/08820139.2017.1379024DOI Listing
January 2018
4 Reads

Primary adrenal insufficiency due to X-linked adrenoleukodystrophy diagnosed in adulthood.

Endocrinol Diabetes Nutr 2017 Oct 2;64(8):458-459. Epub 2017 Aug 2.

Servicio de Endocrinología y Nutrición, Hospital Universitario Son Espases, Palma de Mallorca, Islas Baleares, España.

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http://dx.doi.org/10.1016/j.endinu.2017.07.001DOI Listing
October 2017

Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.

Brain 2017 Sep;140(9):2460-2474

Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

See Jellinger (doi:10.1093/awx190) for a scientific commentary on this article. The enzyme monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA, respectively) are drug targets in the treatment of Parkinson's disease. Read More

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http://dx.doi.org/10.1093/brain/awx172DOI Listing
September 2017
15 Reads

Clinical profiles associated with LRRK2 and GBA mutations in Brazilians with Parkinson's disease.

J Neurol Sci 2017 Oct 24;381:160-164. Epub 2017 Aug 24.

Department of Genetics, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by remarkable phenotypic variability. Accumulated evidence points that the manifestation of PD clinical signs might be differentially modified by genetic factors, as mutations in LRRK2 and GBA genes. In this sense, the clarification of the genotype-phenotype correlations in PD has important implications in predicting prognosis and can contribute to the development of specific therapeutic approaches. Read More

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http://dx.doi.org/10.1016/j.jns.2017.08.3249DOI Listing
October 2017
16 Reads

Urinary, bowel and sexual symptoms in a cohort of patients with Friedreich's ataxia.

Orphanet J Rare Dis 2017 09 26;12(1):158. Epub 2017 Sep 26.

Department of Molecular Neuroscience, Ataxia Centre, UCL Institute of Neurology and National Hospital for Neurology & Neurosurgery, Queen Square, London, WC1N 3BG, UK.

Background: Pelvic symptoms are distressing symptoms experienced by patients with Friedreich's Ataxia (FRDA). The aim of this study was to describe the prevalence of lower urinary tract symptoms (LUTS), bowel and sexual symptoms in FRDA.

Methods: Questionnaire scores measuring LUTS, bowel and sexual symptoms were analysed with descriptive statistics as a cohort and as subgroups (Early/Late-onset and Early/Late-stage FRDA) They were also correlated with validated measures of disease severity including those of ataxia severity, non-ataxic symptoms and activities of daily living. Read More

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http://dx.doi.org/10.1186/s13023-017-0709-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615455PMC
September 2017
20 Reads

Exposure to particulate matter air pollution and risk of multiple sclerosis in two large cohorts of US nurses.

Environ Int 2017 12 20;109:64-72. Epub 2017 Sep 20.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, United States; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, United States. Electronic address:

Background: Air pollution is thought to raise the risk of neurological disease by promoting neuroinflammation, oxidative stress, glial activation and cerebrovascular damage. Multiple Sclerosis is a common auto-immune disorder, primarily affecting young women. We conducted, to a large prospective study of particulate matter (PM) exposure and multiple sclerosis (MS) risk in two prospective cohorts of women: the Nurses Health Study (NHS) and the Nurses Health Study II (NHS II). Read More

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http://dx.doi.org/10.1016/j.envint.2017.07.013DOI Listing
December 2017
5 Reads