SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient.
Case Rep Pathol 2017 11;2017:9403467. Epub 2017 Oct 11.
Department of Cardiac Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany.
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare SMARCA4-driven aggressive malignancy of young age characteristically associated with paraneoplastic hypercalcemia. Comparable neoplasms/presentations have not been reported in males. A 39-year-old male heart transplant recipient (HTX 40 months previously) presented with multiple liver nodules and hypercalcemic crisis. Read More