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    Verification of candidate microRNA markers for parathyroid carcinoma.
    Endocrine 2018 Feb 16. Epub 2018 Feb 16.
    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
    Purpose: Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of miRNA markers in a new series of samples to explore their potential significance in PCa diagnosis. Read More

    A nomogram based on the characteristics of metastatic lymph nodes to predict papillary thyroid carcinoma recurrence.
    Thyroid 2018 Feb 14. Epub 2018 Feb 14.
    West China Hospital of Sichuan University, Chengdu, Sichuan, China ;
    Background And Aims: The extent of metastatic LN invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk.

    Patients And Methods: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in our study. Read More

    Rare and changeable as a chameleon: paraneoplastic syndromes in renal cell carcinoma.
    World J Urol 2018 Feb 10. Epub 2018 Feb 10.
    Department of Urology, Eberhard Karls University Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
    Introduction: Paraneoplastic syndromes (PNS) in renal cell carcinoma (RCC) are important to be recognized by the treating physician, because they may lead to diagnosis of underlying malignant disease. On the other hand, PNS may dominate the clinical picture and can hide the true disorder like a chameleon. When realized, a PNS can be used as a 'neoplastic tumour marker', especially in case of recurrence. Read More

    CUNR scoring system for the prediction of lateral lymph node metastasis in papillary thyroid carcinoma.
    Oncotarget 2018 Jan 30;9(1):167-177. Epub 2017 Nov 30.
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu 610041, China.
    Objective: Our present study aimed to evaluate and compare the number and rate of central lymph node metastases (LNMs) for the prediction of lateral LNM (LLNM) in papillary thyroid carcinoma (PTC) and to develop a scoring system.

    Results: Capsule invasion, tumor location in the upper portion of the thyroid, an ipsilateral central compartment LNM number ≥3, and an ipsilateral central compartment LNM rate of ≥56% were identified as significant independent predictors of ipsilateral lateral LNM in PTC. The predictive ability of an ipsilateral central compartment LNM rate ≥56% (area under the curve (AUC) = 0. Read More

    Probability of Positive Genetic Testing Results in Patients with Family History of Primary Hyperparathyroidism.
    J Am Coll Surg 2018 Feb 2. Epub 2018 Feb 2.
    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, DC. Electronic address:
    Background: Approximately 10% of patients with primary hyperparathyroidism (PHPT) have hereditary disease. Hereditary PHPT may be syndromic (multiple endocrine neoplasia (MEN1, 2, 4), hyperparathyroidism-jaw tumor syndrome) or non-syndromic (familial isolated primary hyperparathyroidism). There are limited data on the probability of testing positive for genetic mutation based on clinical presentation. Read More

    Does the number of parathyroid glands autotransplanted affect the incidence of hypoparathyroidism and recovery of parathyroid function?
    Surgery 2018 Feb 2. Epub 2018 Feb 2.
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address:
    Background: The relationship between the number of parathyroid glands autotransplanted and hypoparathyroidism as well as recovery of parathyroid function is not understood fully. The aim was to ascertain whether the number of autotransplanted glands affected the incidence of hypoparathyroidism and recovery of parathyroid function in long-term follow-up after thyroidectomy.

    Methods: A retrospective cohort study included all patients with papillary thyroid carcinoma who underwent first-time total thyroidectomy with central neck dissection between June 2012 and June 2015. Read More

    [A comparison of clinical characteristics between 2 pedigrees of multiple endocrine neoplasia type 2A with different RET mutations].
    Zhonghua Nei Ke Za Zhi 2018 Feb;57(2):134-137
    Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
    Multiple endocrine neoplasia type 2A (MEN2A) is a hereditary syndrome. Here, two different RET proto-oncogen mutation were identified from family members of two MEN2A pedigrees by genetic screening. One RET mutations were found at codons 1893 and 1895 in exon 11 (1893-1895delCGA) from pedigree 1, which is a novel mutation, the other occurs at codon 634 (Cys634Arg) in exon 11 from pedigree 2. Read More

    Influence of magnesium and parathyroid hormone on cisplatin-induced nephrotoxicity in esophageal squamous cell carcinoma.
    Oncol Lett 2018 Jan 3;15(1):658-664. Epub 2017 Nov 3.
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
    Magnesium (Mg) supplementation has previously been demonstrated to confer protective effects against nephrotoxicity induced by cisplatin. Parathyroid hormone (PTH) regulates Mg homeostasis. The aim of present study was to determine the protective effects of Mg supplementation against cisplatin-induced nephrotoxicity and its association with PTH levels in patients with esophageal squamous cell carcinoma (ESCC). Read More

    Anesthetic management of primary hyperparathyroidism during pregnancy: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9390
    Department of Anesthesiology, Peking University Third Hospital, Beijing, China.
    Rationale: Primary hyperparathyroidism (PHPT) during pregnancy is rare. Nevertheless, hypercalcemia secondary to gestational PHPT may be masked by physiological changes in calcium homeostasis during pregnancy. Gestational PHPT constitutes a serious danger to mother and fetus. Read More

    Superior mediastinal typical carcinoid detected by 99mTc-MIBI SPECT/CT imaging: A case report.
    Medicine (Baltimore) 2017 Dec;96(52):e9457
    Rationale: This is a rare case of mediastinal typical carcinoid tumor with elevated parathyroid hormone (PTH) and hypercalcemia detected by Tc -methoxy-isobutyl-isonitrile(Tc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT) imaging.

    Patient Concerns: A 65-year-old male patient presented with hypercalcemia and elevated PTH.

    Diagnoses: The preoperative diagnosis was ectopic parathyroid adenoma in the right superior mediastinum. Read More

    Independent predictors and lymph node metastasis characteristics of multifocal papillary thyroid cancer.
    Medicine (Baltimore) 2018 Feb;97(5):e9619
    Thyroid and Parathyroid Surgery Center, West China Hospital.
    The multifocal papillary thyroid cancer (PTC), with more aggressive and poorer prognosis, is not rare in papillary histotype. Few studies evaluated risk factors and lymph node metastasis in multifocal PTC. The aim of this present study focusing on risk factors and lymph node metastasis characteristics in multifocal PTC was excepted to assist clinical decisions regarding surgery. Read More

    Parathyroid carcinoma: an unusual presentation of a rare neoplasm.
    Ger Med Sci 2017 28;15:Doc21. Epub 2017 Dec 28.
    National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
    Parathyroid carcinoma is an extremely rare malignant endocrine neoplasm that is very challenging in its diagnosis as well as its treatment. Clinically the disease is detected earlier in patients who present with hyperparathyroidism with signs of profound hypercalcemia. Differentiation between benign and malignant disease of the parathyroid is challenging both for the clinician and for the pathologist. Read More

    Parathyroid carcinoma: From a case report to a review of the literature.
    Int J Surg Case Rep 2018 22;42:214-217. Epub 2017 Nov 22.
    Serviço de Cirurgia Geral, Centro Hospitalar do Porto, Hospital Santo António, Porto, Portugal.
    Introduction: Parathyroid carcinoma is a rare endocrine malignancy. The reported incidence is from 0.5 to 5% of primary hyperparathyroidism cases in various series. Read More

    Non-mammalian models of multiple endocrine neoplasia type 2.
    Endocr Relat Cancer 2018 Feb;25(2):T91-T104
    Department of Cell Developmental and Regenerative Biology, School of Biomedical Sciences, Icahn School of Medicine, New York, New York, USA
    Twenty-five years ago, RET was identified as the primary driver of multiple endocrine neoplasia type 2 (MEN2) syndrome. MEN2 is characterized by several transformation events including pheochromocytoma, parathyroid adenoma and, especially penetrant, medullary thyroid carcinoma (MTC). Overall, MTC is a rare but aggressive type of thyroid cancer for which no effective treatment currently exists. Read More

    Clinical characteristics and treatment outcomes of parathyroid carcinoma: A retrospective review of 234 cases.
    Oncol Lett 2017 Dec 27;14(6):7276-7282. Epub 2017 Sep 27.
    Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
    Parathyroid carcinoma (PC) is one of the rarest known types of cancer and has a moderate prognosis, with estimated 5- and 10-year overall survival rates between 78-85% and between 49-70%, respectively. To raise awareness of this disease, and to optimize its diagnosis, clinical management and prognosis, the present study retrospectively reviewed 234 cases of PC. A total of 226 cases of PC, which were archived between 1984 and 2015 in the three major databases of the Chinese population, were retrieved and pooled with the 8 cases diagnosed and treated at the Department of Thyroid Surgery of The First Hospital of Jilin University (Changchun, China) between June 2008 and December 2015. Read More

    Squamous Cell Carcinoma Lung with Skeletal Muscle Involvement: A 8-year Study of a Tertiary Care Hospital in Kashmir.
    Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):456-460
    Department of Medical Oncology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
    Aims: Lung cancer is the most common malignancy throughout the world. Nonsmall cell lung cancer (NSCLC) is the most common type, and squamous cell type is most common in India. Mostly, patients present with chest-related symptoms and signs. Read More

    Diagnosis, management, histology and genetics of sporadic primary hyperparathyroidism: old knowledge with new tricks.
    Endocr Connect 2018 Feb 12;7(2):R56-R68. Epub 2018 Jan 12.
    Department of Thyroid and Endocrine SurgeryImperial College London, London, UK.
    Primary hyperparathyroidism (pHPT) is a common endocrinopathy resulting from inappropriately high PTH secretion. It usually results from the presence of a single gland adenoma, multiple gland hyperplasia or rarely parathyroid carcinoma. All these conditions require different management, and it is important to be able to differentiate the underlined pathology, in order for the clinicians to provide the best therapeutic approach. Read More

    gene mutations in endocrine tumors.
    Endocr Relat Cancer 2018 Mar 12;25(3):R197-R208. Epub 2018 Jan 12.
    Division of PathologyDepartment of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
    In this review, the importance of thegene in the function of endocrine cells is discussed. There is conclusive evidence thatmutations play a crucial role in the development, progression, cell proliferation, therapeutic responsiveness and behavior of several endocrine tumors. We review the literature ofgene mutations in thyroid, parathyroid, pituitary, pineal gland, endocrine pancreas, paragangliomas, medullary, adrenocortical, ovarian and testicular tumors. Read More

    Parafibromin-deficient (HPT-JT Type, CDC73 Mutated) Parathyroid Tumors Demonstrate Distinctive Morphologic Features.
    Am J Surg Pathol 2018 Jan 10. Epub 2018 Jan 10.
    Sydney Medical School, University of Sydney, Sydney.
    The gene CDC73 (previously known as HRPT2) encodes the protein parafibromin. Biallelic mutation of CDC73 is strongly associated with malignancy in parathyroid tumors. Heterozygous germline mutations cause hyperparathyroidism jaw tumor syndrome,which is associated with a high life-time risk of parathyroid carcinoma. Read More

    Synchronous parathyroid adenoma and papillary thyroid carcinoma: 99mTc-MIBI Scan Findings.
    Niger J Clin Pract 2017 Nov;20(11):1510-1512
    Department of Radiology, Cumhuriyet University Hospital, Sivas, Turkey.
    Simultaneous existence of parathyroid adenoma and thyroid nonmedullary carcinoma is rarely observed. A 52-year-old female was diagnosed approximately 4 years ago with primary hyperparathyroidism (PHPT) on the basis of hypercalcemia and elevated serum parathyroid hormone (PTH) level. Clinically, PHPT diagnosed patient was examined with Tc-99m MIBI scintigraphy to investigate parathyroid adenoma. Read More

    Effect of autotransplantation of a parathyroid gland on hypoparathyroidism after total thyroidectomy.
    Endocr Connect 2018 Feb 4;7(2):286-294. Epub 2018 Jan 4.
    Department of Thyroid Surgery, West China Hospital, Sichuan UniversityChengdu, China.
    Background: The effect of parathyroid autotransplantation on hypoparathyroidism is not fully understood. The purpose of the study was to determine the effect of autotransplantation of a parathyroid gland on the incidence of hypoparathyroidism and recovery of parathyroid function at 6 months after total thyroidectomy with central neck dissection for papillary thyroid carcinoma.

    Methods: All patients with autotransplantation of a parathyroid gland (no inadvertent parathyroidectomy) (group A),preservation of all parathyroid glands (no autotransplantation and inadvertent parathyroidectomy) (group B) or inadvertent removal of a parathyroid gland (no autotransplantation) (group C) who underwent first-time total thyroidectomy with central neck dissection for papillary thyroid carcinoma between January 2013 and June 2016 were included retrospectively. Read More

    Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3195-3200. Epub 2017 Dec 28.
    Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. Read More

    Non-functioning parathyroid cystic tumour: malignant or not? Report of a case.
    G Chir 2017 Sep-Oct;38(5):243-249
    Parathyroid carcinoma (PC) is a very rare endocrine tumour, usually characterized by symptoms such as a neck mass, dysphonia, severe hypercalcemia exceeding 140 mg/L and elevated serum parathyroid hormone levels, even more than 5 times the upper limit of normal. Non-functioning parathyroid cancer is extremely rare and, in this case, its pre-operative diagnosis is often difficult. A 54-year old female patient, referring dysphagia and dysphonia, underwent neck ultrasound and neck CT. Read More

    Decreased expression of PTH1R is a poor prognosis in hepatocellular carcinoma.
    Cancer Biomark 2017 Dec 15. Epub 2017 Dec 15.
    Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
    Background And Aim: Hypercalcemia is a potentially fatal and not rare complication of hepatocellular carcinoma (HCC), and its underlying mechanism remains unclear. Parathyroid hormone (PTH) is the most important regulator of the concentrations of calcium and phosphate in blood; parathyroid hormone-related protein (PTHrP) was the most frequent cause of humoral hypercalcemia of malignancy; parathyroid hormone 1 receptor (PTH1R) is the common receptor for PTH and PTHrP. The aim of this study is to investigate the expression of PTH, PTHrP, and PTH1R in HCC tissues, and their relationship with clinical pathological characters in HCC. Read More

    Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion.
    J Endocr Soc 2017 Jul 25;1(7):926-930. Epub 2017 May 25.
    Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine, New Haven, Connecticut 06520.
    Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a rare autosomal dominant cause of familial hyperparathyroidism associated with benign, ossifying fibromas of the maxillofacial bones and increased risk of parathyroid carcinoma. The putative tumor suppressor genehas been implicated in the syndrome, with a multitude of inactivating mutations identified; however, HPT-JT due to large-scale deletion of the chromosomal region containing the gene is exceedingly rare, and the clinical significance of this variant remains unclear. We report the case of a 32-year-old woman with a history of mandibular ossifying fibroma who presented with primary hyperparathyroidism and was found to harbor a large-scale, germline deletion on chromosome 1q31, including thelocus. Read More

    An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma.
    Turk J Surg 2017 1;33(4):243-247. Epub 2017 Dec 1.
    Department of General Surgery, Ümraniye Training and Research Hospital, İstanbul, Turkey.
    Objective: To evaluate the clinical characteristics of a patient operated for water-clear cell adenoma and to discuss these in the light of relevant literature.

    Material And Methods: PubMed and Google Scholar were searched to identify articles related to water-clear cell adenoma using the following keywords: parathyroid tissue, parathyroid gland, parathyroid cells, parathyroid adenoma, parathyroid hyperplasia, water-clear-cell, and water clear cell. The search included case reports, review articles, and original articles that had been published between January 1990 and November 2014 without any restrictions on language. Read More

    Clinical Characteristics, Causes and Survival in 115 Cancer Patients with Parathyroid Hormone Related Protein-mediated Hypercalcemia.
    J Bone Metab 2017 Nov 30;24(4):249-255. Epub 2017 Nov 30.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
    Background: The aim of this study is to determine the proportion of cancers presenting with parathyroid hormone (PTH) related protein (PTHrP)-mediated hypercalcemia, examine the clinical and biochemical characteristics, identify predictive factors for survival. And we also compared those characteristics between solid organ and hematologic malignancy groups.

    Methods: Cancer patients with PTHrP-mediated hypercalcemia who were treated at Chonnam National University Hospital in Korea from January 2005 to January 2015 were retrospectively reviewed. Read More

    Pathological bone fractures in a patient with parathyroid carcinoma - A Case Report.
    J Pak Med Assoc 2017 Dec;67(12):1956-1958
    Services Institute of Medical Sciences, University of Health Sciences, Lahore, Pakistan.
    Parathyroid carcinoma is a rare malignant neoplasm of the parathyroid glands which results in enlargement and excessive production of parathyroid hormone (PTH) responsible for pathologically raising calcium levels in the blood resulting in bone pain/fractures, renal stones and other signs of hypercalcaemia. A 37 year old woman presented with sudden, spontaneous bone pain and fracture of the right femoral shaft. This unusual presentation was explained by extremely high PTH levels and hypercalcaemia in the blood and a hard, solitary mass palpable in the neck. Read More

    Polyclonal origin of parathyroid tumors is common and is associated with multiple gland disease in primary hyperparathyroidism.
    Surgery 2018 Jan;163(1):9-14
    Division of General and Oncologic Surgery, Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD. Electronic address:
    Background: Parathyroid tumors are mostly considered monoclonal neoplasms, the rationale for focused parathyroidectomy in primary hyperparathyroidism. We reported that flow sorting parathyroid tumor cells and methylation-sensitive polymerase chain reaction (me-PCR) of polymorphic human androgen receptor gene and phosphoglycerate kinase gene alleles in deoxyribonucleic acid reveals that ≤35% of parathyroid tumors are polyclonal. We sought to confirm these findings and assess for clinical relevance. Read More

    Heritable forms of primary hyperparathyroidism: a current perspective.
    Histopathology 2018 Jan;72(1):117-132
    Rhode Island Hospital and Alpert School of Medicine of Brown University, Providence, RI, USA.
    Primary hyperparathyroidism (PHPT) is one of the most common of all endocrine disorders encountered by the practising histopathologist. The vast majority of lesions are sporadic in nature, approximately 85% of which are parathyroid adenomas, while hyperplasia and carcinoma account for 10-15% and fewer than 1%, of cases, respectively. Heritable forms of PHPT are much less common and present challenges both to clinicians and pathologists, particularly when they are the presenting feature of an endocrine syndrome. Read More

    Parathyroid carcinoma occurred in two glands in multiple endocrine neoplasia 1: a report on a rare case.
    Endocr J 2017 Dec 8. Epub 2017 Dec 8.
    Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, Tokyo, Japan.
    Primary hyperparathyroidism is the most common hormonal manifestation associated with multiple endocrine neoplasia 1 (MEN1). It is generally caused by parathyroid hyperplasia, and parathyroid carcinoma is rare. Here, we report a case of MEN1 with parathyroid carcinoma in two parathyroid glands causing primary hyperparathyroidism. Read More

    Unusual pathological fracture of the clavicle revealing primary hyperparathyroidism: a case report.
    J Med Case Rep 2017 Dec 9;11(1):342. Epub 2017 Dec 9.
    Department of Nuclear Medicine, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.
    Background: Primary hyperparathyroidism revealed by a pathological fracture is very uncommon; in the majority of cases the discovery of lytic bone lesions on imaging examinations evokes in the clinician first a neoplastic etiology and a metabolic origin is often omitted. This case report adds to the existing literature as it describes an unusual presentation of primary hyperparathyroidism.

    Case Presentation: We report a case of a 50-year-old Moroccan man, without any known tumor, who presented a fracture of his left clavicle with multiple osteolytic lesions on computed tomography suggesting bone metastases. Read More

    Response to transarterial chemoembolization may serve as selection criteria for hepatocellular carcinoma liver transplantation.
    Oncotarget 2017 Oct 24;8(53):91328-91342. Epub 2017 Aug 24.
    Transplantation Center,West China Hospital of Sichuan University, Chengdu, China.
    Aims: This study sought to extend the inclusion criteria for hepatocellular carcinoma (HCC) liver transplantation (LT), particularly addressing the safety and effectiveness of pre-LT transarterial chemoembolization (TACE).

    Materials And Methods: Our study included 115 patients with HCC who underwent LT after TACE. The response measured after each TACE session was based on the mRECIST criteria: complete response (CR), partial response (PR), stable disease (SD) or progressive disease (PD). Read More

    Characteristics, management, and outcome of primary hyperparathyroidism at a single clinical center from 2005 to 2016.
    Osteoporos Int 2017 Dec 3. Epub 2017 Dec 3.
    Department of General Surgery, Center of Thyroid and Parathyroid, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
    This study presents the clinical and biochemical profiles of patients with PHPT between 2005 and 2016 at our center. Most PHPT patients in China show symptomatic features. The number of symptomatic and asymptomatic patients increased during that time, and the number of individuals with parathyroid carcinoma is now increasing. Read More

    A case report of brown tumor in a patient with chronic renal failure and renal cell carcinoma.
    Diagn Cytopathol 2017 Nov 29. Epub 2017 Nov 29.
    Department of Pathology, Penn State Health, Milton S. Hershey Medical Center & Penn State College of Medicine, Hershey, Pennsylvania.
    We report a case of a 72 year old male with hyperparathyroidism secondary to end stage diabetic renal disease and coexisting bilateral chromophobe renal cell carcinomas. The patient presented with back and groin pain, right pelvic hemorrhage, and multiple lytic bone lesions concerning for metastatic renal cell carcinoma. Fine needle aspiration cytology demonstrated benign appearing osteoclasts and spindled cells. Read More

    [False negative spect parathyroid scintigraphy with sestamibi in patients with primary hyperparathyroidism].
    Rev Med Chil 2017 Aug;145(8):1021-1027
    Sección Endocrinología, Hospital Clínico, Universidad de Chile, Santiago, Chile.
    Background: 99mTc-sestamibi parathyroid SPECT scintigraphy is a useful tool in the pre-operative study of hyperparathyroidism. False negatives (FN) have been reported in 5.7-14% of the examinations. Read More

    [Metabolic disorders as paraneoplastic syndromes].
    Internist (Berl) 2018 Feb;59(2):114-124
    Klinik für Innere Medizin I, Martin-Luther-Universität Halle/Wittenberg, Ernst-Grube-Str. 40, 06114, Halle (Saale), Deutschland.
    Paraneoplastic syndromes are characterized by the tumor-induced release of peptide hormones and/or the initiation of immune phenomena, which elicit clinical changes and alterations in laboratory parameters independent of the tumor size and spread. In addition to neurological, endocrinal and rheumatological phenotypes, metabolic alterations play a special role in the clinical routine as they commonly present with acute symptoms in an emergency situation and necessitate immediate diagnosis and prompt initiation of treatment. Metabolic alterations within the framework of malignant diseases should be treated in a multidisciplinary team and it is often necessary to perform monitoring and treatment in an intensive care unit. Read More

    Twist on a classic: vitamin D and hypercalcaemia of malignancy.
    BMJ Case Rep 2017 Nov 23;2017. Epub 2017 Nov 23.
    Department of Medicine, Cornell University Joan and Sanford I Weill Medical College, New York, USA.
    Malignancy is the most common cause of hypercalcaemia in the inpatient setting. Most cases are caused by tumour production of parathyroid hormone-related protein and osseous metastases. In less than 1% of cases, hypercalcaemia is driven by increased production of 1,25-dihydroxyvitamin D (1,25(OH)D), a mechanism most commonly seen in haematological malignancies. Read More

    SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient.
    Case Rep Pathol 2017 11;2017:9403467. Epub 2017 Oct 11.
    Department of Cardiac Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany.
    Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare SMARCA4-driven aggressive malignancy of young age characteristically associated with paraneoplastic hypercalcemia. Comparable neoplasms/presentations have not been reported in males. A 39-year-old male heart transplant recipient (HTX 40 months previously) presented with multiple liver nodules and hypercalcemic crisis. Read More

    De novo head and neck cancer arising in solid organ transplantation recipients: The Asan Medical Center experience.
    Auris Nasus Larynx 2017 Nov 14. Epub 2017 Nov 14.
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:
    Objective: De novo cancers of head and neck area in solid organ transplantation recipients show standardized incidence ratio (SIR) of 3.8. Immunosuppression following transplantation is suggested to play as a crucial factor in pathogenesis of secondary malignancy. Read More

    Two-stage thyroidectomy in the era of intraoperative neuromonitoring.
    Gland Surg 2017 Oct;6(5):453-463
    Department of Endocrine Surgery, Central Clinic of Athens, Athens, Greece.
    Background: The use of intraoperative neuromonitoring (IONM) provides surgeons with real time information about recurrent laryngeal nerves (RLN) functional integrity. Hence, allowing them to modify the initially scheduled bilateral procedure, to a two-stage thyroidectomy in cases of loss of signal (LOS) on the first side of resection resulting in minimization of bilateral RLN injury. The purpose of our study was to present our results since the implementation of the above mentioned process in both malignant and benign thyroid disease. Read More

    Associations between RET tagSNPs and their haplotypes and susceptibility, clinical severity, and thyroid function in patients with differentiated thyroid cancer.
    PLoS One 2017 13;12(11):e0187968. Epub 2017 Nov 13.
    Department of Head and Neck, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
    Background: It is unclear whether common genetic variants of the RET proto-oncogene contribute to disease susceptibility, clinical severity, and thyroid function in differentiated thyroid cancer (DTC).

    Methods: A total of 300 DTC patients and 252 healthy controls were enrolled in this study. Seven RET tagging single nucleotide polymorphisms were genotyped using the KASPar platform. Read More

    Importance of surgeon-performed ultrasound in the preoperative nodal assessment of patients with potential thyroid malignancy.
    Surgery 2018 Jan 8;163(1):112-117. Epub 2017 Nov 8.
    Case Western Reserve School of Medicine, Cleveland, OH. Electronic address:
    Introduction: A comprehensive cervical ultrasound evaluation is essential in the operative planning of patients with thyroid disease. Reliance on radiographic reports alone may result in incomplete operative management as pathologic lymph nodes are often not palpable and evaluation of the lateral neck is not routine. This study examined the role of surgeon-performed ultrasound in the evaluation of patients who underwent lateral neck dissection for thyroid cancer. Read More

    Transcriptomic analyses reveal the underlying pro-malignant functions of PTHR1 for osteosarcoma via activation of Wnt and angiogenesis pathways.
    J Orthop Surg Res 2017 Nov 9;12(1):168. Epub 2017 Nov 9.
    Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, 44, Xiaoheyan Road, Dadong District, Shenyang, Liaoning, 110042, China.
    Background: Increasing evidence has indicated parathyroid hormone type 1 receptor (PTHR1) plays important roles for the development and progression of osteosarcoma (OS). However, its function mechanisms remain unclear. The goal of this study was to further illuminate the roles of PTHR1 in OS using microarray data. Read More

    Atypical manifestation of parathyroid carcinoma with late-onset distant metastases.
    Endocrinol Diabetes Metab Case Rep 2017 28;2017. Epub 2017 Oct 28.
    Department of Pathophysiology, National and Kapodistrian University of Athens, Athens, Greece.
    Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4. Read More

    Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure.
    Surgery 2018 Jan 3;163(1):31-34. Epub 2017 Nov 3.
    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, DC. Electronic address:
    Background: Hereditary primary hyperparathyroidism may be syndromic or nonsyndromic (familial isolated hyperparathyroidism). Recently, germline activating mutations in the GCM2 gene were identified in a subset of familial isolated hyperparathyroidism. This study examined the clinical and biochemical characteristics and the treatment outcomes of GCM2 mutation-positive familial isolated hyperparathyroidism as compared to sporadic primary hyperparathyroidism. Read More

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