12,954 results match your criteria Parathyroid Carcinoma


Pseudolaric acid B exhibits anti-cancer activity on human hepatocellular carcinoma through inhibition of multiple carcinogenic signaling pathways.

Phytomedicine 2018 Nov 19;59:152759. Epub 2018 Nov 19.

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Pseudolaric acid B (PAB), a diterpene acid isolated from the root bark of Pseudolarix kaempferi, exhibits a potent anti-cancer activity in a variety of tumor cells.

Purpose: The present study was designed to evaluate the anti-cancer effects of PAB on hepatocellular carcinoma (HCC) cell lines in vitro, and to explore the underlying mechanism.

Methods: The anti-proliferative activity of PAB on HCC cells were assessed via sulforhodamine B staining, colony formation, cell cycle analysis, respectively. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.019DOI Listing
November 2018

Parathyroid carcinoma, an unusual cause of primary hyperparathyroidism.

Acta Otorrinolaringol Esp 2019 Apr 14. Epub 2019 Apr 14.

Servicio de Otorrinolaringología, Complexo Hospitalario Universitario A Coruña, A Coruña, España.

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https://linkinghub.elsevier.com/retrieve/pii/S00016519193003
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http://dx.doi.org/10.1016/j.otorri.2018.11.001DOI Listing
April 2019
1 Read

Recurrence of papillary thyroid carcinoma from the residual pyramidal lobe: a case report and literature review.

Medicine (Baltimore) 2019 Apr;98(15):e15210

Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China.

Rationale: Recurrence of papillary thyroid carcinoma (PTC) usually requires a second operation, which carries a high complication rate, especially if central neck dissection (CND) is necessary. Recurrent PTC from pyramidal lobe is a rare entity, which is mainly due to non-standardized operation. However, literature on this topic is limited. Read More

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http://dx.doi.org/10.1097/MD.0000000000015210DOI Listing
April 2019
1 Read

Genome-wide analysis of differentially expressed lncRNA in sporadic parathyroid tumors.

Osteoporos Int 2019 Apr 10. Epub 2019 Apr 10.

Department of Medical Genetics and Developmental Biology, Capital Medical University, Beijing, 100069, China.

Diagnosis of parathyroid carcinoma on histological examination is challenging. Thousands of differentially expressed lncRNAs were identified on the microarray data between parathyroid cancer and adenoma samples. Four lncRNAs were significantly dysregulated in further validation. Read More

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http://dx.doi.org/10.1007/s00198-019-04959-yDOI Listing
April 2019
1 Read

[Endoscopic selective lateral neck dissection via a chest-breast approach for papillary thyroid carcinoma: preliminary experience in 20 cases].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):346-350

Department of Breast and Thyroid Surgery, the First People's Hospital of Zunyi, Zunyi, 563000, China.

To explore the feasibility of endoscopic selective lateral neck dissection(SLND) via a chest-breast approach.We retrospectively reviewed 20 patients who underwent endoscopic total thyroidectomy along with SLND, between January 2017 and May 2018. All the 20 patients underwent total thyroidectomy, central lymph nodes dissection and selective lateral lymph nodes dissection with endoscopic surgery via chest-breast approach. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.014DOI Listing
April 2019
1 Read

Clock genes and cancer development in particular in endocrine tissues.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

G Chrousos, Pediatrics, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece.

Circadian rhythms in central and peripheral level are operated by transcriptional/translational feedback loops involving a set of genes called 'clock genes' that are implicated in the development of several diseases including malignancies. Dysregulation of Clock system can affect cancer susceptibility by regulating DNA damage and repair mechanisms as well as apoptosis. A number of oncogenic pathways can be dysregulated via clock genes' epigenetic alterations including hypermethylation of clock genes' promoters or variants of clock genes. Read More

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http://dx.doi.org/10.1530/ERC-19-0094DOI Listing
April 2019
2 Reads

Early Calcium Supplementation After Total Thyroidectomy Can Prevent Symptomatic Hypocalcemia - Findings from a Retrospective Study.

Gulf J Oncolog 2019 Jan;1(29):60-65

Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kannur, Kerala, India.

Introduction: Thyroidectomy for thyroid cancers and central neck dissection are considered as independent predictors of postoperative hypocalcemia. Post-surgical hypocalcemia is the most common and often the most difficult long-term consequence of thyroid surgeries. Management of hypocalcemia is done with calcium supplementation, but there is no consensus on the timing and the amount of calcium supplementation. Read More

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January 2019
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Management of brown tumor of spine with primary hyperparathyroidism: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(14):e15007

Spinal tumor center, Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Rationale: Brown tumor (BT) is a rare benign lesion in skeletal system. It is especially rare secondary to primary hyperparathyroidism (HPT). The differential diagnosis can be misleading due to its diversified clinical characteristics. Read More

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http://dx.doi.org/10.1097/MD.0000000000015007DOI Listing
April 2019
3 Reads

Routine low-dose calcium supplementation after thyroidectomy does not reduce the rate of symptomatic hypocalcemia: a prospective randomized trial.

Ann Surg Treat Res 2019 Apr 28;96(4):177-184. Epub 2019 Mar 28.

Department of Surgery, Ewha Womans University Medical Center, Seoul, Korea.

Purpose: Routine supplementation of high-dose calcium significantly decreased the risk of postoperative symptomatic hypocalcemia after thyroidectomy. However, there is an ongoing debate about whether the same results can be achieved with low-dose calcium supplementation.

Methods: Patients (n = 138) who underwent total thyroidectomy for thyroid cancer were 1:1 randomly assigned to receive oral supplements of 1,500 mg/day elemental calcium and 1,000 IU/day cholecalciferol for 2 weeks or no supplementation. Read More

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http://dx.doi.org/10.4174/astr.2019.96.4.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444042PMC
April 2019
3 Reads

Application of Carbon Nanoparticles in Endoscopic Thyroidectomy via Bilateral Areola Approach: Total Thyroidectomy Plus Central Lymph Node Dissection.

J Laparoendosc Adv Surg Tech A 2019 Apr 1. Epub 2019 Apr 1.

1 Division of Thyroid Surgery, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, China-Japan Union Hospital of Jilin University, Changchun City, Jilin Province, P. R. China.

Background: The aim of this report was dual: (a) to describe the step-by-step standardized intraoperative percutaneous injection of carbon nanoparticles (CNPs) procedure for CNP-stained central compartment lymph nodes (CLNs) and passive display of parathyroid gland by CNP-stained thyroid in endoscopic thyroidectomy via bilateral areola approach (ETBAA) and (b) evaluation and outcomes of percutaneous injection of CNPs in total thyroidectomy plus CLN dissection through ETBAA.

Materials And Methods: Video describes the technique of intraoperative percutaneous injection of CNPs for central compartment LNs identification, dissection, and parathyroid glands preservation in ETBAA for papillary thyroid cancer.

Results: Supplementary video shows that after intrathyroid injection of CNPs, black carbon can be seen rapidly along the lymphatic vessels to the surrounding LNs. Read More

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http://dx.doi.org/10.1089/lap.2019.0102DOI Listing
April 2019
1 Read

Parathyroid carcinoma: a case report.

Exp Oncol 2019 Mar;41(1):72-75

State Scientific Institution "Scientific-Practical Centre of Preventive and Clinical Medicine", State Administration of Affairs, Kyiv, Ukraine.

Parathyroid carcinoma (PC) is an uncommon cause of primary hyperparathyroidism (pHPT). The tumor is mostly functioning with following high serum calcium and parathyroid hormone (PTH) levels. Consideration of PC in differential diagnosis of pHPT is important because the mortality and the prognosis depend on early recognition and surgical approach. Read More

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March 2019
2 Reads

Diagnostic and prognostic implications of parafibromin immunohistochemistry in parathyroid carcinoma.

Biosci Rep 2019 Mar 29. Epub 2019 Mar 29.

Department of Urology, Chosun University HospitalChosun University School of Medicine, Gwangju, Korea (South), Republic of

The aim of this study was to elucidate the diagnostic and prognostic implications of parafibromin immunohistochemistry (IHC) in parathyroid carcinoma (PC). We performed a meta-analysis to examine the rate of loss of parafibromin expression from 18 eligible studies. In addition, a diagnostic test accuracy review was conducted to investigate the diagnostic role of parafibromin in PC. Read More

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http://dx.doi.org/10.1042/BSR20181778DOI Listing
March 2019
3 Reads
2.637 Impact Factor

Parafibromin immunostainings of parathyroid tumors in clinical routine: a near-decade experience from a tertiary center.

Mod Pathol 2019 Mar 28. Epub 2019 Mar 28.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

The cell division cycle 73 gene is mutated in familial and sporadic forms of primary hyperparathyroidism, and the corresponding protein product parafibromin has been proposed as an adjunct immunohistochemical marker for the identification of cell division cycle 73 mutations and parathyroid carcinoma. Here, we present data from our experiences using parafibromin immunohistochemistry in parathyroid tumors since the marker was implemented in clinical routine in 2010. A total of 2019 parathyroid adenomas, atypical adenomas, and carcinomas were diagnosed in our department, and parafibromin staining was ordered for 297 cases with an initial suspicion of malignant potential to avoid excessive numbers of false positives. Read More

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http://dx.doi.org/10.1038/s41379-019-0252-6DOI Listing
March 2019
1 Read

Challenges in the treatment of parathyroid carcinoma: a case report.

Hormones (Athens) 2019 Mar 23. Epub 2019 Mar 23.

Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo 636, 95122, Catania, Italy.

Introduction: Parathyroid carcinoma (PC) is a rare neoplasm with a high rate of recurrence and an indolent course. It is frequently functional, causing nearly 1% of the cases of primary hyperparathyroidism (HPT), and in some cases, it may be complicated by brown tumors, mimicking bone metastases. Synchronous parathyroid and papillary thyroid carcinomas are rare. Read More

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http://dx.doi.org/10.1007/s42000-019-00104-wDOI Listing
March 2019
2 Reads

Diagnostic Pitfall: Parathyroid Carcinoma Expands the Spectrum of Calcitonin and Calcitonin Gene-Related Peptide Expressing Neuroendocrine Neoplasms.

Endocr Pathol 2019 Mar 22. Epub 2019 Mar 22.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s12022-019-9572-9DOI Listing
March 2019
1 Read

Detailed comparison of robotic and endoscopic transaxillary thyroidectomy.

Asian J Surg 2019 Mar 19. Epub 2019 Mar 19.

Department of Surgery, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Robotic thyroidectomy is increasingly used for patients with papillary thyroid carcinoma (PTC). We compared the differences between robotic and endoscopic transaxillary thyroidectomy with regard to surgical procedures.

Methods: This retrospective study enrolled 40 patients with PTC who underwent robotic hemithyroidectomy (robot group) using the Da Vinci S system and 37 patients (endoscopic group) who underwent endoscopic hemithyroidectomy. Read More

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http://dx.doi.org/10.1016/j.asjsur.2019.02.012DOI Listing
March 2019
3 Reads
0.758 Impact Factor

Exosomal miRNA423-5p mediated oncogene activity in papillary thyroid carcinoma: a potential diagnostic and biological target for cancer therapy.

Authors:
W Ye X Deng Y Fan

Neoplasma 2019 Mar 7. Epub 2019 Mar 7.

Department of General Surgery, Center of Thyroid and Parathyroid, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Exosomes are considered important "messengers" between cells and their cargo, and some of the miRNAs composing their cargo may be involved in oncogenic activity. Exosomal miRNA423-5p (Ex-miRNA423-5p) is upregulated in gastric cancer and associated with its poor prognosis. However, the role of exosome-derived miRNAs in papillary thyroid cancer (PTC) is still unclear and needs further study. Read More

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http://dx.doi.org/10.4149/neo_2018_180824N643DOI Listing
March 2019
1 Read

Fortuitous discovery of non-fluorocholine-fixing papillary carcinoma of vesicular variant of the thyroid.

Eur Arch Otorhinolaryngol 2019 May 14;276(5):1541-1544. Epub 2019 Mar 14.

Centre hospitalo-universitaire de Nîmes, Service d'oto-rhino-laryngologie, Rue du Professeur Robert Debré, 30900, Nîmes, France.

Purpose: Characterization of thyroid nodules is crucial to propose surgical intervention for histological verification. Cervical ultrasound potentially combined with fine needle aspiration is recommended, and fluorocholine positron emission tomography (FCH-PET), commonly used in prostatic cancers, has been evaluated in the diagnosis of thyroid cancers in recent publications.

Methods: We present two cases of patients with multinodular thyroid and primary hyperparathyroidism. Read More

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http://dx.doi.org/10.1007/s00405-019-05370-3DOI Listing
May 2019
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THE INFLUENCE OF SURGICAL EXTENT AND PARAFIBROMIN STAINING ON THE OUTCOME OF PARATHYROID CARCINOMA: 20-YEAR EXPERIENCE FROM A SINGLE INSTITUTE.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

From: 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.

Objective: Parathyroid carcinoma (PC) is a rare endocrine malignancy with a poor prognosis. The optimal surgical procedure and prognostic factors for PC remain controversial.

Design: Clinical information and parafibromin staining result from 53 patients with PC was reviewed retrospectively from 1997 to 2018. Read More

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http://dx.doi.org/10.4158/EP-2018-0538DOI Listing
March 2019
1 Read

Aggressive papillary thyroid carcinoma in a child with type 2 congenital generalized lipodystrophy.

Arch Endocrinol Metab 2019 Feb;63(1):79-83

Grupo Brasileiro para Estudos de Lipodistrofias Herdadas e Adquiridas (BRAZLIPO), Hospital Universitário Walter Cantídio, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.

Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital generalized lipodystrophy (CGL) with autosomal recessive inheritance is a rare disease and is characterized by the lack of adipose tissue, severe insulin resistance, and early metabolic disturbances. Read More

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http://dx.doi.org/10.20945/2359-3997000000096DOI Listing
February 2019
3 Reads

Multiple endocrine neoplasia type 2A syndrome (MEN2A) and usefulness of 68Ga-DOTATATE PET/CT in this syndrome.

Ann Ital Chir 2019 Mar 4;8. Epub 2019 Mar 4.

Aim: The aim of this study was to evaluate a new imaging method 68Ga-DOTATATE PET/CT as an alternative method to diagnose evidence of neuroendocrine tumors or their metastasis (if any) in patient with MEN 2A.

Methods: Three patients( 2F, 1M; age 28,46 and 50 years) with MEN 2A syndrome who underwent 68Ga-DOTATATE PET/CT scan were prospectively evaluated. PET/CT images were analyzed with measurement of maximum standardized uptake value (SUVmax). Read More

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March 2019
5 Reads
0.683 Impact Factor

Ectopic Parathyroid Adenoma in Piriform Sinus: Case Report and Review of the Literature.

Ear Nose Throat J 2019 Jan 28;98(1):14-17. Epub 2019 Jan 28.

1 Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

During routine blood work, a 53-year-old female patient was noted to have asymptomatic hypercalcemia and subsequently found to have hyperparathyroidism. Localization studies for a suspected parathyroid adenoma included Tc Sestamibi scintigraphy, Single Photon Emission Computed Tomography (SPECT)/computed tomography (CT) study, and ultrasound of the neck, which were initially read as negative for parathyroid adenoma. A contrast-enhanced CT scan of the neck was performed to locate the suspected parathyroid adenoma and demonstrated a soft tissue lesion within the right piriform sinus. Read More

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http://dx.doi.org/10.1177/0145561318822933DOI Listing
January 2019
2 Reads

The role of thymus preservation in parathyroid gland function and surgical completeness after bilateral central lymph node dissection for papillary thyroid cancer: A randomized controlled study.

Int J Surg 2019 Feb 26;65:1-6. Epub 2019 Feb 26.

Department of General Surgery of Changzheng Hospital Affiliated to Second Military Medical University, 200003, Shanghai, China. Electronic address:

Background: The clinical value of thymus preservation during thyroid carcinoma surgery remains unclear. The aim of this study is to explore the role of bilateral thymus preservation in parathyroid glands (PGs) function and surgical completeness in total thyroidectomy (TT) with bilateral central lymph node dissection (CLND).

Materials And Methods: Fifty-four consecutive patients who underwent TT and bilateral CLND were assigned to the thymus preservation (TP) group (n = 27) and the bilateral thymectomy (BT) group (n = 27). Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.013DOI Listing
February 2019
2 Reads

Primary hyperparathyroidism due to ectopic parathyroid adenoma in an adolescent: a case report and review of the literature.

Endocrine 2019 Apr 25;64(1):38-42. Epub 2019 Feb 25.

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

Purpose: Primary hyperparathyroidism (PHPT) is a common endocrine disorder and is usually diagnosed in adults. PHPT due to ectopic parathyroid adenoma in adolescents is rare.

Methods: We describe the case of a 15-year-old boy with PHPT due to ectopic parathyroid adenoma. Read More

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http://dx.doi.org/10.1007/s12020-019-01875-3DOI Listing
April 2019
1 Read
3.527 Impact Factor

Utilization of cross-matched blood in elective thyroid and parathyroid surgeries: a single-center retrospective study.

Int J Gen Med 2019 8;12:87-90. Epub 2019 Feb 8.

Department of Otorhinolaryngology, Head and Neck Surgery, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

Background: Hospital blood banks face the common challenge of maintaining an adequate supply of blood products to serve all potential patients while minimizing the need to discard expired blood products. This study aimed to determine the risk of blood transfusion during elective thyroid and parathyroid surgery and potential factors related to blood loss and risk of transfusion in these cases.

Methods: The study included all thyroid and parathyroid surgeries performed at King Abdulaziz University Hospital between January 2015 and December 2017. Read More

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https://www.dovepress.com/utilization-of-cross-matched-blood
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http://dx.doi.org/10.2147/IJGM.S170328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371940PMC
February 2019
4 Reads

Metastasis of renal cell carcinoma to the parathyroid gland 12 years after radical nephrectomy.

J Surg Case Rep 2019 Feb 19;2019(2):rjz032. Epub 2019 Feb 19.

General Surgery Department, Unidade Local de Saúde do Baixo Alentejo, Beja 7801-849, Portugal.

Renal cell carcinoma (RCC) accounts for 2-3% of all malignant tumors in adults. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after several years, is common. Involvement of the parathyroid gland has only four reported cases in literature. Read More

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http://dx.doi.org/10.1093/jscr/rjz032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380075PMC
February 2019
3 Reads

Characterization of a novel CDC73 gene mutation in a hyperparathyrodism-jaw tumor patient affected by parathyroid carcinoma in the absence of somatic loss of heterozygosity.

Endocr J 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery and Translational Medicine, University of Florence, Unit of Bone and Mineral Diseases, University Hospital of Florence, Florence 50139, Italy.

Hyperparathyrodism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder. Loss of function of the cell division cycle protein 73 homolog (CDC73) gene is responsible for the syndrome. This gene encodes an ubiquitously expressed 531 amino acid protein, parafibromin, that acts as a tumor suppressor. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0387DOI Listing
February 2019
1 Read

Commentary: Next-Generation Sequence Analysis of Parathyroid Carcinoma.

J Endocr Soc 2019 Mar 22;3(3):560-562. Epub 2018 Oct 22.

Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut School of Dental Medicine, Farmington, Connecticut.

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http://dx.doi.org/10.1210/js.2018-00315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378759PMC

A review of parathyroid mass and patients with nonspecific complaints.

J Int Med Res 2019 Feb 21:300060519827169. Epub 2019 Feb 21.

Department of Internal Medicine, Amasya University Research and Education Hospital, Amasya, Turkey.

In this review, parathyroid mass and its nonspecific symptoms are discussed. In daily clinical practice, patients present with varying symptoms, including depression, chest pain, pancreatitis, or nonspecific fatigue. If the patient is not tested for a parathyroid mass along with performing routine electrolyte tests, diagnosing such a patient with a parathyroid mass may take several years. Read More

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http://dx.doi.org/10.1177/0300060519827169DOI Listing
February 2019
2 Reads

Comprehensive Genomic Characterization of Parathyroid Cancer Identifies Novel Candidate Driver Mutations and Core Pathways.

J Endocr Soc 2019 Mar 3;3(3):544-559. Epub 2018 Sep 3.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Context: Elucidating the genomic landscape of sporadic parathyroid carcinoma (PC) has been limited by low tumor incidence.

Objective: Identify driver mutations of sporadic PC and potential actionable pathways.

Methods: Patients undergoing surgical resection for sporadic PC between 1980 and 2016 at MD Anderson Cancer Center were identified. Read More

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https://academic.oup.com/jes/article/3/3/544/5088041
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http://dx.doi.org/10.1210/js.2018-00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372985PMC
March 2019
7 Reads

Parathyroid Carcinoma and Persistent Hypercalcemia: A Case Report and Review of Therapeutic Options.

Saudi J Med Med Sci 2018 May-Aug;6(2):115-118. Epub 2018 Apr 16.

Department of Endocrinology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Parathyroid carcinomas are very uncommon, accounting for 0.1% to 5% of all causes of primary hyperparathyroidism. Parathyroid-jaw tumor syndrome, with a mutation in that encodes parafibromin, is the most common genetic association. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_104_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196698PMC
April 2018
1 Read

The diagnostic value of 4D MRI at 3T for the localization of parathyroid adenomas.

Eur J Radiol 2019 Mar 22;112:207-213. Epub 2019 Jan 22.

Department of General Surgery, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

Purpose: The aim of this study was to assess the feasibility of four-dimensional magnetic resonance imaging (4D MRI) at 3 T for the localization of parathyroid adenomas.

Materials And Methods: Preoperative 4D MRI scans, encompassing dynamic contrast-enhanced (DCE) sequences and non-contrast enhanced (non-CE) sequences, including a T2-weighted multipoint Dixon (T2-mDixon) sequence, with in-phase, out-phase, and water-only images, were evaluated retrospectively in 41 patients with surgically proven parathyroid lesions. Two readers who were blinded to the surgical findings independently reviewed the images in two sessions (non-CE sequences alone and non-CE + DCE sequences). Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.022DOI Listing
March 2019
2 Reads

Robotic transoral thyroidectomy: Total thyroidectomy and ipsilateral central neck dissection with da Vinci Xi Surgical System.

Head Neck 2019 May 13;41(5):1536-1540. Epub 2019 Feb 13.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Background: Transoral approach for thyroidectomy draws attention recently among the thyroid surgeons, with the merits of cosmetic outcomes and minimal flap dissection. The aim of this study is to demonstrate the details and the steps of transoral robotic thyroidectomy.

Methods: We made three incisions in the gingival-buccal sulcus for three 8-mm intraoral ports: one inverted U-shaped 1-cm midline incision approximately 2 cm above the frenulum, and two 0. Read More

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http://dx.doi.org/10.1002/hed.25661DOI Listing

Parathyroid adenoma with prominent lymphocytic infiltrate having histological features highly suggestive of IgG4-related disease: a case report and literature review.

Endocr J 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Parathyroid adenoma with prominent lymphocytic infiltrate is a rare disease. Until now, 11 patients have been reported. Herein, we report a 57-year-old man who had a neck mass that was incidentally found. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0428DOI Listing
February 2019
2 Reads

Neck Dissection in the Surgical Treatment of Thyroid Cancer.

Endocrinol Metab Clin North Am 2019 03 26;48(1):143-151. Epub 2018 Dec 26.

Otolaryngology Department, Augusta University, Thyroid and Parathyroid Center, 1120 Fifteenth Street, BP-4109, Augusta, GA 30912-4060, USA. Electronic address:

The incidence of thyroid cancer is increasing, largely attributable to overdetection related to prevalent diagnostic and radiologic imaging modalities. Papillary thyroid cancer remains the most common thyroid malignancy. It has a high tendency for regional metastasis to the cervical lymph nodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898529183059
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http://dx.doi.org/10.1016/j.ecl.2018.11.004DOI Listing
March 2019
16 Reads

[Application of carbon nano-particles in total thyroidectomy combined with lymphadenectomy in area Ⅵ].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):28-32

Department of Head and Neck Surgery, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.

To evaluate the effects of staining with carbon nanoparticles on the identification of parathyroid glands and lymph nodes during thyroid carcinoma surgery combined with lymphadenectomy. A total of 194 patients with papillary thyroid carcinoma who underwent thyroidectomy combined with lymphadenectomy from April 2016 to January 2018 were reviewed. Of them 104 cases were injected with carbon nanoparticles in operation area (nanocarbon group) and other 90 cases without the injection of carbon nanoparticles were as control group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.007DOI Listing
January 2019

Diagnostic pitfalls in a cystic ectopic intrathyroidal parathyroid adenoma mimicking a nodular goiter: A care-compliant case report.

Medicine (Baltimore) 2019 Feb;98(5):e14351

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Cystic parathyroid adenomas are rare and seldom arise in ectopically located glands which may be found within the carotid sheath, mediastinum, thymus, or thyroid grand. They cannot be detected consistently by any imaging methods. Unusual symptoms may bring about certain pitfalls and difficulties for the diagnosis of primary hyperparathyroidism (PHPT) caused by cystic parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380700PMC
February 2019
4 Reads

Parathyroid adenoma presenting with spontaneous cervical and anterior mediastinal hemorrhage: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14347

Department of Surgery, Division of Surgical Oncology.

Rationale: Spontaneous anterior cervical or mediastinal hemorrhage is a rare presentation of parathyroid adenoma.

Patient Concerns: A 69-year-old woman presented with neck hematoma and dysphagia and was found to have a soft tissue mass adjacent to her thyroid gland as seen on MRI and neck ultrasound.

Diagnosis: Laboratory testing demonstrated elevated calcium and parathyroid hormone supporting diagnosis of parathyroid adenoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000014347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380857PMC
February 2019
2 Reads

The role of combined techniques of scintigraphy and SPECT/CT in the diagnosis of primary hyperparathyroidism: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14154

"Lucian Blaga" University of Sibiu, Romania.

Rationale: Primary hyperparathyroidism, usually as a result of a hyperfunctioning parathyroid gland, represents more than 90% cases of patients evaluated for hypercalcemia. Combined techniques of preoperative scintigraphy and SPECT/CT serve as a successful minimally-invasive parathyroidectomy. This recent imaging method provides four-dimensional functional images with advanced contrast resolution which greatly facilitates preoperative localization of parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358356PMC
January 2019
2 Reads

Perioperative characteristics, histological diagnosis, and outcome in cats undergoing surgical treatment of primary hyperparathyroidism.

Vet Surg 2019 Apr 21;48(3):367-374. Epub 2019 Jan 21.

VCA Canada-404 Veterinary Emergency and Referral, Newmarket, Ontario, Canada.

Objective: To report perioperative characteristics, complications, histopathologic diagnosis and outcome in cats undergoing surgical treatment for primary hyperparathyroidism (PHPT).

Study Design: Multi-institutional, retrospective case series.

Animals: Thirty-two client-owned cats. Read More

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http://dx.doi.org/10.1111/vsu.13165DOI Listing
April 2019
5 Reads
1.041 Impact Factor

The role of ultrasound in the diagnosis of the coexistence of primary hyperparathyroidism and non-medullary thyroid carcinoma.

BMC Med Imaging 2019 01 18;19(1). Epub 2019 Jan 18.

Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, 200233, China.

Background: The coexistence of primary hyperparathyroidism(PHPT) and papillary thyroid cancer(PTC) is a known entity; it is a rare and complicated setting for diagnostic imaging.

Methods: After reviewing clinical data of 112 patients who had been treated for PHPT in our facility between January 2015 and December 2017, we identified 7 non-medullary thyroid carcinoma (NMTC) (6.25%). Read More

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http://dx.doi.org/10.1186/s12880-019-0306-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339388PMC
January 2019
4 Reads
0.983 Impact Factor

The incidence of post-thyroidectomy hypocalcaemia: a retrospective single-centre audit.

Ann R Coll Surg Engl 2019 Apr 15;101(4):273-278. Epub 2019 Jan 15.

East and North Hertfordshire NHS Trust, Stevenage , Hertfordshire , UK.

Introduction: The aim of this single centre retrospective observational record-based audit was to assess the incidence of post-thyroidectomy hypocalcaemia. The setting was a district general hospital in Hertfordshire covering a population of 500,000 people. A total of 196 patients who had had total or completion thyroidectomy during a five-year period were included in the study. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432957PMC
April 2019
3 Reads

Parathyroid Carcinoma.

Front Horm Res 2019 19;51:63-76. Epub 2018 Nov 19.

Parathyroid carcinoma (PC) is a rare endocrine malignancy, accounting for <1% of all cases of sporadic primary hyperparathyroidism (PHPT) and up to 15% in the hereditary hyperparathyroidism-jaw tumor syndrome. Genomic alterations identified in PC are mostly represented by CDC73 gene mutations, codifying for a loss-of-function protein termed parafibromin. Whole exome sequencing identified mutations in other genes, such as mTOR, KMT2D, CDKN2C, THRAP3, PIK3CA, and EZH2 genes, CCND1 gene amplification. Read More

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http://dx.doi.org/10.1159/000491039DOI Listing
November 2018
7 Reads

Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

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https://www.karger.com/Article/FullText/491037
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http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
5 Reads

Primary Hyperparathyroidism.

Authors:
Laura Masi

Front Horm Res 2019 19;51:1-12. Epub 2018 Nov 19.

The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. Read More

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https://www.karger.com/Article/FullText/491034
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http://dx.doi.org/10.1159/000491034DOI Listing
November 2018
12 Reads

Can preoperative vitamin D deficiency predict postoperative hypoparathyroidism following thyroid surgery?

Langenbecks Arch Surg 2019 Feb 14;404(1):55-61. Epub 2019 Jan 14.

Department of Endocrine Surgery, Catholic Hospital Mainz, An der Goldgrube 11, 55131, Mainz, Germany.

Importance: Postoperative hypoparathyroidism remains a relevant problem after thyroid surgery. Although the roles of vitamin D deficiency and other risk factors have been discussed in previous studies, variable results have been reported.

Objective: Predicting the risk of postoperative hypocalcemia could be helpful for individual prognoses and medical treatment. Read More

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http://dx.doi.org/10.1007/s00423-019-01748-3DOI Listing
February 2019
2 Reads

A Case of Pregnancy Complicated by Primary Hyperparathyroidism Due to a Parathyroid Adenoma.

Am J Case Rep 2019 Jan 14;20:53-59. Epub 2019 Jan 14.

Laboratory of Age-Related Metabolic and Endocrine Disorders, The Russian Gerontology Clinical Research Center, Moscow, Russian Federation.

BACKGROUND Primary hyperparathyroidism is most common in women during the menopause and its occurrence in pregnant women is rare. However, because neonatal mortality is associated with maternal hyperparathyroidism, early diagnosis is essential. This report describes the case of a late diagnosis of primary hyperparathyroidism in a 28-year-old pregnant woman and describes the effects on the mother and neonate. Read More

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http://dx.doi.org/10.12659/AJCR.912436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340266PMC
January 2019
5 Reads

MRI findings and utility of DWI in the evaluation of solid parathyroid lesions.

Radiol Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Radiology, Bezmialem Vakif University, Istanbul, Turkey.

Purpose: To evaluate the MRI findings of solid parathyroid lesions and to elaborate on a possible improvement of MRI detection of parathyroid lesions by the use of additional DWI.

Materials And Methods: MRI and DWI properties of pathologically proven 20 solid parathyroid lesions were retrospectively reviewed. Mean ADC values (b50 + b400 + b800/3) of parathyroid lesions were compared with that of normal appearing thyroid parenchyma (TP), sternocleidomastoid muscle (SCM) and jugulodigastric lymph nodes (JDLN). Read More

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http://link.springer.com/10.1007/s11547-018-0970-8
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http://dx.doi.org/10.1007/s11547-018-0970-8DOI Listing
January 2019
2 Reads

Two Different Causes of Paediatric Hypercalcaemia.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e389-e392. Epub 2018 Dec 19.

Department of Otorhinolaryngology, Pardubice Hospital, Pardubice, Czech Republic.

Paediatric hypercalcaemia is a rare condition which can be easily overlooked or misdiagnosed. We report two paediatric patients who presented to the Department of Paediatrics, Pardubice Hospital, Pardubice, Czech Republic, in 2009 and 2010, respectively. Each patient was diagnosed with hypercalcaemia due to a different cause. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307649PMC
August 2018
3 Reads