14,146 results match your criteria Parathyroid Carcinoma


Tumor size rather than the thyroid invasion affects the prognosis of parathyroid carcinoma without lymph node or distant metastasis.

Eur Arch Otorhinolaryngol 2022 May 21. Epub 2022 May 21.

Department of Otolaryngology Head and Neck Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, Guangdong, People's Republic of China.

Purpose: This study aimed to explore the prognostic value of thyroid invasion of parathyroid carcinoma without lymph node or distant metastasis.

Methods: Two hundred and nine cases of parathyroid carcinoma from the SEER (1989-2014) were eligible for this study. A Chi-squared test, t test, X-tile, Kaplan-Meier curves, and multivariate Cox proportional hazard regression were used for analysis. Read More

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Germline Mutations Related to Primary Hyperparathyroidism Identified by Next-Generation Sequencing.

Front Endocrinol (Lausanne) 2022 28;13:853171. Epub 2022 Apr 28.

Department of Internal Medicine, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

Primary hyperparathyroidism (PHPT) is characterized by overproduction of parathyroid hormone and subsequent hypercalcemia. Approximately 10% of PHPT cases are hereditary, and several genes, such as , , , and , are responsible for the familial forms of PHPT. However, other genetic mutations involved in the etiology of PHPT are largely unknown. Read More

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The Long Non-Coding BC200 Is a Novel Circulating Biomarker of Parathyroid Carcinoma.

Front Endocrinol (Lausanne) 2022 2;13:869006. Epub 2022 May 2.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Long non-coding RNAs (lncRNAs) are an important class of epigenetic regulators involved in both physiological processes and cancer development. Preliminary evidence suggested that lncRNAs could act as accurate prognostic and diagnostic biomarkers. Parathyroid cancer is a rare endocrine neoplasia, whose management represents a clinical challenge due to the lack of accurate molecular biomarkers. Read More

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Genotype-Phenotype Correlations in Asian Indian Children and Adolescents with Primary Hyperparathyroidism.

Calcif Tissue Int 2022 May 14. Epub 2022 May 14.

Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, 400012, India.

Childhood and adolescent primary hyperparathyroidism (PHPT) is a very rare disease. Data on its molecular genetics are scarce. We performed a retrospective analysis (January 2000-January 2021) to determine the deleterious germline variants and genotype-phenotype correlations in children and adolescents < 20 years diagnosed with PHPT from a single referral center. Read More

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Applying Machine Learning to Determine 25(OH)D Threshold Levels Using Data from the AMATERASU Vitamin D Supplementation Trial in Patients with Digestive Tract Cancer.

Nutrients 2022 Apr 19;14(9). Epub 2022 Apr 19.

Division of Molecular Epidemiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.

Some controversy remains on thresholds for deficiency or sufficiency of serum 25-hydroxyvitamin D (25(OH)D) levels. Moreover, 25(OH)D levels sufficient for bone health might differ from those required for cancer survival. This study aimed to explore these 25(OH)D threshold levels by applying the machine learning method of multivariable adaptive regression splines (MARS) in post hoc analyses using data from the AMATERASU trial, which randomly assigned Japanese patients with digestive tract cancer to receive vitamin D or placebo supplementation. Read More

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Synchronous Parathyroid Carcinoma and Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features.

Cureus 2022 Apr 10;14(4):e24006. Epub 2022 Apr 10.

Department of General Surgery, Salmaniya Medical Complex, Manama, BHR.

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Compared to parathyroid adenoma, parathyroid cancer is more likely to be associated with marked levels of serum parathyroid hormone (PTH) and hypercalcemia with severe clinical manifestations. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a rare variant of papillary thyroid cancer. Read More

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Giant cervical goiter in Hashimoto's thyroiditis: A case report.

J Int Med Res 2022 May;50(5):3000605221096379

The First Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637000, China.

A giant cervical goiter, defined as a thyroid mass larger than 8 cm in diameter, is usually a nodular or adenomatous goiter. A giant cervical goiter can also be caused by hyperthyroidism (i.e. Read More

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Parathyroid Computed Tomography: Pearls, Pitfalls, and Our Approach.

Neuroimaging Clin N Am 2022 May;32(2):413-431

Department of Radiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA.

Parathyroid imaging is predominantly used for preoperative localization of parathyroid lesions in patients with the biochemical diagnosis of primary hyperparathyroidism. Although imaging algorithms vary, in the era of minimally invasive parathyroidectomy for single parathyroid adenomas, multiphase parathyroid computed tomography (CT) (4-dimensional CT) has emerged as a favored modality for presurgical mapping of parathyroid lesions. Implementation and correct interpretation of these studies can be challenging, although confidence and accuracy improve with experience and volume. Read More

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An effective and safe alternative treatment method in parathyroid adenomas: Radiofrequency ablation.

J Clin Ultrasound 2022 05;50(4):547-548

Department of Endocrinology, Kutahya Health Science University, School of Medicine, Kutahya, Turkey.

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Severe Hypercalcemia as an Initial Presentation of Advanced Hepatocellular Carcinoma: A Case Report.

Cancer Manag Res 2022 28;14:1577-1580. Epub 2022 Apr 28.

Radiology Department, Mogadishu Somali Turkey, Recep Tayyip Erdogan, Training and Research Hospital, Mogadishu, Somalia.

Background: It is extremely rare for hypercalcemia to appear as the first symptom of hepatocellular carcinoma. Instead, it occurs primarily as a paraneoplastic manifestation after the disease is already diagnosed.

Methods: In this report, we describe a 55-year-old woman who presented with symptoms of acute severe hypercalcemia and was negative for hepatitis B surface antigen and hepatitis C virus antibodies. Read More

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Single-incision port robot-assisted surgery for thymic carcinoid tumor resection.

J Cardiothorac Surg 2022 May 3;17(1):90. Epub 2022 May 3.

Department of Thoracic Surgery, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Multiple endocrine neoplasia (MEN) is divided into MEN type 1 (MEN-1) and MEN type 2 (MEN-2). MEN-1 may be associated with thymic carcinoid tumors. We present a case of the surgical removal of a thymic carcinoid associated with MEN-1 via a single-incision port RATS. Read More

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Parathyroid venous sampling for the preoperative localisation of parathyroid adenoma in patients with primary hyperparathyroidism.

Sci Rep 2022 Apr 29;12(1):7058. Epub 2022 Apr 29.

Department of Internal Medicine, Endocrine Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Preoperative localisation studies are essential for parathyroidectomy in patients with primary hyperparathyroidism. If the location of abnormal parathyroid glands cannot be identified through non-invasive studies, parathyroid venous sampling (PVS) may be employed. In this study, we evaluated the utility of preoperative PVS in parathyroid surgery. Read More

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A comprehensive review of the "tigroid" background cytological concept: what, when, where and why?

Pathologica 2022 Apr;114(2):121-127

Department of Pathology, University Hospital La Paz, Madrid, Spain.

The concept of "tigroid" background is used in cytology to describe a peculiar smear background characterized by the presence of a relatively granular, reticulated material that was described as "foamy, lazy, tiger-striped or astrakhan". It was used to describe the background seen in smears obtained from seminoma. In addition to seminoma, we now know that it can be present in different tumours, mostly carcinomas and round cell sarcomas. Read More

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Neuroendocrine Carcinoma as a Cause of Humoral Hypercalcemia of Malignancy: A Case of a Patient With Elevated Parathyroid Hormone-Related Protein.

Cureus 2022 Mar 22;14(3):e23398. Epub 2022 Mar 22.

Hematology and Oncology, Brooke Army Medical Center, San Antonio, USA.

Humoral hypercalcemia of malignancy (HHM) is a paraneoplastic syndrome caused by elevations in parathyroid hormone-related protein (PTH-rP). HHM often presents in patients with squamous cell carcinomas of the lung, head, and neck, as well as breast, ovarian, renal, and bladder carcinomas. HHM associated with neuroendocrine carcinoma (NEC) is rarely observed. Read More

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Expression Profile of Myoepithelial Cells in DCIS: Do They Change From Protective Angels to Wicked Witches?

Appl Immunohistochem Mol Morphol 2022 Apr 26. Epub 2022 Apr 26.

Centre for Tumour Biology, Institute of Cancer & CR-UK Clinical Centre, Barts and The London School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ.

The mechanism of transition of ductal carcinoma in situ (DCIS) to invasive cancer is elusive but recently changes in the myoepithelial cells (MECs) have been implicated. The aim of this study is to investigate the changes in gene profile of MECs in DCIS that could compromise their tumor suppressor function leading to promotion of tumor progression. Immuno-laser capture microdissection (LCM) was used to isolate MECs from normal and DCIS breast tissues followed by whole genome expression profiling using Affymetrix HGU-133 plus2. Read More

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Parathyroid Carcinoma: a Review.

Indian J Surg Oncol 2022 Mar 3;13(1):133-142. Epub 2021 Jun 3.

Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, Room No 621, 6th floor Homi Bhabha Block, Parel, Mumbai, 400012 India.

Parathyroid cancer is a rare endocrine malignancy with only a few thousand cases reported worldwide. As a result, there exists considerable controversy regarding the various aspects of this disease, viz., etiology, diagnosis, and management. Read More

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Revision Thyroid Surgery.

Indian J Surg Oncol 2022 Mar 4;13(1):199-207. Epub 2021 Nov 4.

Department of Head and Neck Oncology, All India Institute of Medical Sciences, Raipur, India.

The incidence of recurrence in well-differentiated thyroid malignancies range from 10 to 30%. It is estimated that about 31-46% of patients with differentiated thyroid cancer will have the persistent disease and 1.2-6. Read More

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Vitamin D Deficiency in Women with Breast Cancer: A Correlation with Osteoporosis? A Machine Learning Approach with Multiple Factor Analysis.

Nutrients 2022 Apr 11;14(8). Epub 2022 Apr 11.

Translational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.

Breast cancer (BC) is the most frequent malignant tumor in women in Europe and North America, and the use of aromatase inhibitors (AIs) is recommended in women affected by estrogen receptor-positive BCs. AIs, by inhibiting the enzyme that converts androgens into estrogen, cause a decrement in bone mineral density (BMD), with a consequent increased risk of fragility fractures. This study aimed to evaluate the role of vitamin D3 deficiency in women with breast cancer and its correlation with osteoporosis and BMD modifications. Read More

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PTH-Independent Paraneoplastic Hypercalcemia in a Child with Nonmetastatic Renal Ewing Sarcoma.

Indian J Pediatr 2022 06 20;89(6):621. Epub 2022 Apr 20.

Hematology-Oncology Unit, Advanced Pediatrics Center, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

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Evaluation of multinodular goiter and primary hyperparathyroidism leads to a diagnosis of AL amyloidosis.

Thyroid Res 2022 Apr 20;15(1). Epub 2022 Apr 20.

Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.

Background: Amyloid goiter, defined as excess amyloid within the thyroid gland in such quantities that it produces a clinically apparent goiter, is a very rare manifestation of systemic amyloidosis with cases commonly seen in the setting of Amyloid A (AA) amyloidosis. Amyloid goiter as the primary clinical manifestation secondary to Amyloid light chain (AL) amyloidosis is very rare. We present a case of AL amyloidosis with initial manifestation as goiter with amyloid deposition in the thyroid and the parathyroid gland. Read More

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PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.

Breast Cancer Res 2022 Apr 19;24(1):30. Epub 2022 Apr 19.

Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, 300 Cedar Street, TAC S120, Box 208020, New Haven, CT, 06520-8020, USA.

Background: Parathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when it is produced by alveolar epithelial cells and secreted into the maternal circulation to mobilize skeletal calcium used for milk production. PTHrP is also produced by breast cancers, and GWAS studies suggest that it influences breast cancer risk. However, the exact functions of PTHrP in breast cancer biology remain unsettled. Read More

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Contemporary Multimodality Imaging of Primary Hyperparathyroidism.

Radiographics 2022 May-Jun;42(3):841-860. Epub 2022 Apr 15.

From the Department of Radiology (M.N., S.R.K., A.A., J.E.J., C.J.H., T.D.B.) and Department of Endocrine and Thyroid Surgery (F.P.), Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, England; Department of Radiology, Dartford and Gravesham NHS Trust, Kent, England (D.O.); and Department of Surgery and Cancer, Imperial College London, London, England (T.D.B.).

Primary hyperparathyroidism (PHPT) is a disorder characterized by hypercalcemia and an elevated or inappropriately normal parathyroid hormone level. Classic features include bone pain, fractures, renal impairment, nephrolithiasis, and mental disturbance. However, most cases of PHPT are now asymptomatic at diagnosis or associated with nonspecific neurocognitive changes. Read More

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A visual deep learning model to predict abnormal versus normal parathyroid glands using intraoperative autofluorescence signals.

J Surg Oncol 2022 Apr 13. Epub 2022 Apr 13.

Department of Endocrine Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Previous work demonstrated that abnormal versus normal parathyroid glands (PGs) exhibit different patterns of autofluorescence, with former appearing darker and more heterogenous. Our objective was to develop a visual artificial intelligence model using intraoperative autofluorescence signals to predict whether a PG is abnormal (hypersecreting and/or hypercellular) or normal before excision during surgical exploration for primary hyperparathyroidism.

Methods: A total of 906 intraoperative parathyroid autofluorescence images of 303 patients undergoing parathyroidectomy/thyroidectomy were used to develop model. Read More

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Triple water clear cell parathyroid adenomas: a rare cause of primary hyperparathyroidism.

BMJ Case Rep 2022 Apr 12;15(4). Epub 2022 Apr 12.

Endocrine Surgery, Evangelistria Medical Centre, Nicosia, Cyprus

A man in his 70s was referred to the endocrine surgery department after incidental finding of hypercalcaemia during preoperative work-up for abdominal aortic aneurysm repair. The patient reported severe fatigue and malaise with no previous history of nephrolithiasis or osteoporosis. After biochemical confirmation of primary hyperparathyroidism, localisation studies suggested multiple gland disease. Read More

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Giant parathyroid adenoma: a case report.

J Med Case Rep 2022 Apr 13;16(1):150. Epub 2022 Apr 13.

Department of Surgery, Urmia University of Medical Sciences, Urmia, Iran.

Background: Giant parathyroid adenoma is a type of parathyroid adenoma weighing > 3.5 g and having a size of more than 2 cm.

Case Presentation: This report describes giant primary parathyroid adenoma with reference to the literature. Read More

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Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway.

BMC Mol Cell Biol 2022 Apr 12;23(1):18. Epub 2022 Apr 12.

Medical School, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, People's Republic of China.

Background: Triple-negative breast cancer (TNBC) is the most severe type of breast cancer owing to its high heterogeneity, aggressiveness and lack of treatment. Studies have reported that uncarboxylated osteocalcin (GluOC) promotes the development of prostate and other cancers. Studies have also found elevated levels of serum osteocalcin in breast cancer patients with bone metastasis, and serum osteocalcin can be a marker of bone metastasis. Read More

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Extract (Pc-Ex) Containing Emodin Suppresses Lung Cancer-Induced Cachexia by Suppressing TCF4/TWIST1 Complex-Induced PTHrP Expression.

Nutrients 2022 Apr 5;14(7). Epub 2022 Apr 5.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, 268 Chungwon-daero, Chungju 27478, Korea.

Cachexia, which is characterised by the wasting of fat and skeletal muscles, is the most common risk factor for increased mortality rates among patients with advanced lung cancer. (parathyroid hormone-like hormone) is reported to be involved in the pathogenesis of cancer cachexia. However, the molecular mechanisms underlying the regulation of expression and the inhibitors of PTHLH have not yet been identified. Read More

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Intrathyroidal Parathyroid Carcinoma: Case Report and Literature Review.

Ear Nose Throat J 2022 Apr 9:1455613221093729. Epub 2022 Apr 9.

Department of Otolaryngology-Head and Neck Surgery, 12343Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Intrathyroidal parathyroid carcinoma (PC) is a rare malignancy that is usually difficult to diagnose. We present a case of a 31-year-old male with a history of hyperparathyroidism who was found to have intrathyroidal PC upon review of immunostains along with a review of the current literature. A systematic review of the literature utilizing the PubMed database identified 24 relevant, full-text articles. Read More

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Remote-access hemithyroidectomy in a patient with papillary thyroid cancer after ipsilateral irradiation: a case report.

Gland Surg 2022 Mar;11(3):622-627

Department of Surgery, International Goodwill Hospital, Kanagawa, Japan.

Remote-access thyroidectomy (RAT) is becoming a more frequently used approach that can avoid scars in the neck and provide better cosmetic results than open surgery. However, there has been no surgical indication for RAT in patients who have a history of cervical treatment (surgery or irradiation), and the use of RAT has been avoided in such patients. Here, we report a case in which a remote-access endoscopic hemithyroidectomy and central lymph node dissection by the anterior chest approach was successfully performed in a patient with papillary thyroid carcinoma (a 77-year-old Japanese male) after he had undergone ipsilateral cervical radiation therapy to parotid gland cancer (mucoepidermoid carcinoma) thirteen years earlier. Read More

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Multimodality imaging in primary hyperparathyroidism.

Clin Radiol 2022 Jun 4;77(6):e401-e416. Epub 2022 Apr 4.

Department of Clinical Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Department of Nuclear Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address:

Institutional variations in parathyroid adenoma localisation are largely dictated by local experience and availability of imaging investigations, with no consensus on the optimal approach. This review evaluates the role of multiple imaging techniques in primary hyperparathyroidism and highlights their advantages and limitations in different clinical contexts. A clinico-radiological review of parathyroid imaging techniques is illustrated with example cases and data from the literature. Read More

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