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    SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient.
    Case Rep Pathol 2017 11;2017:9403467. Epub 2017 Oct 11.
    Department of Cardiac Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany.
    Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare SMARCA4-driven aggressive malignancy of young age characteristically associated with paraneoplastic hypercalcemia. Comparable neoplasms/presentations have not been reported in males. A 39-year-old male heart transplant recipient (HTX 40 months previously) presented with multiple liver nodules and hypercalcemic crisis. Read More

    De novo head and neck cancer arising in solid organ transplantation recipients: The Asan Medical Center experience.
    Auris Nasus Larynx 2017 Nov 14. Epub 2017 Nov 14.
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:
    Objective: De novo cancers of head and neck area in solid organ transplantation recipients show standardized incidence ratio (SIR) of 3.8. Immunosuppression following transplantation is suggested to play as a crucial factor in pathogenesis of secondary malignancy. Read More

    Denosumab Therapy for Refractory Hypercalcemia Secondary to Squamous Cell Carcinoma of Skin in Epidermolysis Bullosa.
    World J Oncol 2015 Apr 12;6(2):345-348. Epub 2015 Apr 12.
    Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool L12 2AP, UK.
    Hypercalcemia secondary to malignancy is rare in children and the majority is caused by tumor-produced parathyroid hormone-related protein (PTHrP). We report a case of hypercalcemia refractory to bisphosphonate and corticosteroid therapy, but responsive to denosumab. A 17-year-old boy with epidermolysis bullosa (EB) and advanced squamous cell carcinoma (SCC) of the left leg was referred with severe hypercalcemia (serum calcium, 4. Read More

    Intrathyroidal Parathyroid Carcinoma Presenting as Asymptomatic High Normal Serum Calcium and Slightly Elevated Intact Parathyroid Hormone: A Case Report and Review of Literature.
    World J Oncol 2011 Jun 8;2(3):138-142. Epub 2011 Jun 8.
    Department of Pathology, Walter Reed Army Medical Center, Bldg 2, 6900 Georgia Ave, Washington, DC 20307, USA.
    Parathyroid carcinoma is an uncommon endocrine malignancy and the probability of an intrathyroidal location is low. We report a case of intrathyroidal parathyroid carcinoma presenting as asymptomatic high normal serum calcium and slightly elevated intact parathyroid hormone (iPTH) making preoperative suspicion and diagnosis extremely difficult. Read More

    A Case of Ovarian Clear Cell Carcinoma Simultaneously Producing Parathyroid Hormone-related Protein and Granulocyte Colony-Stimulating Factor.
    World J Oncol 2010 Jun 19;1(3):138-141. Epub 2010 May 19.
    Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
    We describe the first report of an ovarian clear cell carcinoma simultaneously producing parathyroid hormone-related protein (PTHrP) and granulocyte colony-stimulating factor (G-CSF). A 64-year-old woman complained of general fatigue, loss of appetite, nausea, vomiting and constipation. The results of blood and biochemistry tests were white blood cell count of 21,060 /ml and calcium of 18. Read More

    Two-stage thyroidectomy in the era of intraoperative neuromonitoring.
    Gland Surg 2017 Oct;6(5):453-463
    Department of Endocrine Surgery, Central Clinic of Athens, Athens, Greece.
    Background: The use of intraoperative neuromonitoring (IONM) provides surgeons with real time information about recurrent laryngeal nerves (RLN) functional integrity. Hence, allowing them to modify the initially scheduled bilateral procedure, to a two-stage thyroidectomy in cases of loss of signal (LOS) on the first side of resection resulting in minimization of bilateral RLN injury. The purpose of our study was to present our results since the implementation of the above mentioned process in both malignant and benign thyroid disease. Read More

    Transcriptomic analyses reveal the underlying pro-malignant functions of PTHR1 for osteosarcoma via activation of Wnt and angiogenesis pathways.
    J Orthop Surg Res 2017 Nov 9;12(1):168. Epub 2017 Nov 9.
    Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, 44, Xiaoheyan Road, Dadong District, Shenyang, Liaoning, 110042, China.
    Background: Increasing evidence has indicated parathyroid hormone type 1 receptor (PTHR1) plays important roles for the development and progression of osteosarcoma (OS). However, its function mechanisms remain unclear. The goal of this study was to further illuminate the roles of PTHR1 in OS using microarray data. Read More

    Atypical manifestation of parathyroid carcinoma with late-onset distant metastases.
    Endocrinol Diabetes Metab Case Rep 2017 28;2017. Epub 2017 Oct 28.
    Department of Pathophysiology, National and Kapodistrian University of Athens, Athens, Greece.
    Parathyroid carcinoma is an extremely rare endocrine malignancy that accounts for less than 1% of cases of primary hyperparathyroidism. We report a 44-year-old woman who presented with fatigue and diffuse bone pain. Laboratory findings revealed highly elevated serum calcium and parathyroid hormone (PTH) levels and a 4. Read More

    Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has lesser rate of biochemical cure.
    Surgery 2017 Nov 3. Epub 2017 Nov 3.
    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, DC. Electronic address:
    Background: Hereditary primary hyperparathyroidism may be syndromic or nonsyndromic (familial isolated hyperparathyroidism). Recently, germline activating mutations in the GCM2 gene were identified in a subset of familial isolated hyperparathyroidism. This study examined the clinical and biochemical characteristics and the treatment outcomes of GCM2 mutation-positive familial isolated hyperparathyroidism as compared to sporadic primary hyperparathyroidism. Read More

    MEN1 gene mutation with parathyroid carcinoma: first report of a familial case.
    Endocr Connect 2017 Nov 2;6(8):886-891. Epub 2017 Nov 2.
    Medical GeneticsIRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy
    Background: The occurrence of parathyroid carcinoma in multiple endocrine neoplasia type I (MENI) is rare and the 15 cases of malignant parathyroid tumor reported so far have been associated with MENI in individuals and not with multiple members within a family.

    Methods: We report on a 61-year-old male, operated for a 7.3 cm parathyroid carcinoma infiltrating the esophagus. Read More

    Acute pancreatitis as an initial manifestation of parathyroid carcinoma: A case report and literature review.
    Medicine (Baltimore) 2017 Nov;96(44):e8420
    Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Rationale: Parathyroid carcinoma is a rare endocrine malignancy. Acute pancreatitis as an initial manifestation of parathyroid carcinoma has been rarely reported.

    Patient Concerns: A 22-year-old woman was admitted to emergency room with a sudden attack of severe epigastric pain. Read More

    Carbon nanoparticles facilitate lymph nodes dissection and parathyroid glands identification in reoperation of papillary thyroid cancer.
    Medicine (Baltimore) 2017 Nov;96(44):e8380
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
    The aim of the study was to investigate whether carbon nanoparticles (CNs) can improve the dissection of lymph nodes and protect parathyroid glands (PGs) during reoperation for patients with papillary thyroid carcinoma (PTC).PTC patients who previously underwent thyroidectomy and later received reoperation between January 2009 and January 2016 were retrospectively recruited. We compared the patients who had CN suspension injected into the residual thyroid gland with a control group of patients who did not have the injection. Read More

    Paratharmone related protein (peptide): A novel prognostic, diagnostic and therapeutic marker in Head & Neck cancer.
    J Stomatol Oral Maxillofac Surg 2017 Nov 3. Epub 2017 Nov 3.
    Department of oral medicine and radiology, Sri Hasanamba dental college and hospital, Vidyanagar, 573202 Hassan, Karnataka, India.
    Parathyroid hormone-related protein (PTHrP) is a promising modality of assessment of different critical features of cancer. It is a protein member of parathyroid hormone family, secreted by certain physiologic cells and by malignant tumors in an increased amount. Recent studies have confirmed that PTHrP massively contributes to malignant behaviour of oral cancers-cell proliferation, migration and invasiveness. Read More

    Cytological challenges in the diagnosis of intrathyroidal parathyroid carcinoma: A case report and review of literature.
    Diagn Cytopathol 2017 Oct 27. Epub 2017 Oct 27.
    Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
    Parathyroid carcinoma is an uncommon malignancy and the probability of an intrathyroidal location is low. Fine needle aspirations (FNA) of these presumably "thyroid nodules" can lead to misinterpretation because of the similarities in cytological features of parathyroid and thyroid lesions. Despite limitations, USG guided FNA cytology remains the first line of investigation. Read More

    Patient quality of life and prognosis in MEN2.
    Endocr Relat Cancer 2017 Oct 24. Epub 2017 Oct 24.
    K Winter, Counselling, Association for Multiple Endocrine Neoplasia Disorders, Tunbridge Wells, United Kingdom of Great Britain and Northern Ireland.
    Multiple endocrine neoplasia type 2 (MEN2) refers to the autosomal dominant neuroendocrine tumour syndromes, MEN type 2A (MEN2A) and MEN type 2B (MEN2B). They are typified by the development of medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid hyperplasia in MEN2A, and MTC, phaeochromocytomas, ganglioneuromatosis and skeletal abnormalities in MEN2B. The aggressiveness of MTC is variable according to genotype, and although it is still the major cause of mortality in both conditions, prognosis has improved dramatically in those diagnosed and treated at a young age thanks to predictive genetic testing. Read More

    Chromogranin A as circulating marker for diagnosis and management of neuroendocrine neoplasms: more flaws than fame.
    Endocr Relat Cancer 2017 Oct 24. Epub 2017 Oct 24.
    A Faggiano, Thyroid and Parathyroid Surgery Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy.
    Owing to the heterogeneity of neuroendocrine neoplasms (NENs), the availability of reliable circulating markers is critical for improving diagnostics, prognostic stratification, follow-up, and definition of treatment strategy. This review is focused on Chromogranin A (CgA), a hydrophilic glycoprotein present in large dense core vesicles of neuroendocrine cells. Despite being long identified as the most useful NEN-related circulating marker, clinical application of CgA is controversial. Read More

    The use of cinacalcet hinders the diagnosis of parathyroid carcinoma in a chronic dialysis patient: a case report.
    BMC Nephrol 2017 Oct 18;18(1):315. Epub 2017 Oct 18.
    Department of Nephrology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, Japan.
    Background: Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving chronic dialysis therapy. Although cinacalcet can control parathyroid function and bone turnover, preventing ectopic calcification remains challenging. Cinacalcet can also suppress PTH secretion due to parathyroid carcinoma in the same way as it does for parathyroid hyperplasia in the uremic condition. Read More

    Chromogranin A as a Biochemical Marker for Neuroendocrine Tumors: A Single Center Experience at Royal Hospital, Oman.
    Oman Med J 2017 Sep;32(5):365-370
    Department of Chemical Pathology, Directorate of Laboratory Medicine and Pathology, Royal Hospital, Muscat, Oman.
    Objectives: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman.

    Methods: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014). During this time, 302 CgA tests for 270 patients (119 males and 151 females; age range 11-86 years and mean±standard deviation (SD) 44. Read More

    The diagnostic accuracy of neck ultrasound, 4D-Computed tomographyand sestamibi imaging in parathyroid carcinoma.
    Eur J Radiol 2017 Oct 1;95:82-88. Epub 2017 Aug 1.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
    Introduction: Our aim was to investigate the accuracy of available imaging modalities for parathyroid carcinoma (PC) in our institution and to identify which imaging modality, or combination thereof, is optimal in preoperative determination of precise tumor location.

    Methods: All operated PC patients in our institution between 2000 and 2015 that had at least one of the following in-house preoperative scans: neck ultrasonography (US), neck 4D-Computed Tomography (4DCT) and 99mTc Sestamibi SPECT/CT (MIBI). Sensitivity, specificity and accuracy of PC tumor localization were assessed individually and in combination. Read More

    Nonfunctional double parathyroid carcinoma with incidental thyroid micropapillary carcinoma: a rare case.
    Pan Afr Med J 2017 2;27:241. Epub 2017 Aug 2.
    Department of General Surgery, Gazi University Medical Faculty, Ankara, Turkey.
    Parathyroid carcinomas are rare endocrine tumors which comprise 0.3-5.6% of all causes of hyperparathyroidism. Read More

    Predictive factors and prognosis for recurrent laryngeal nerve invasion in papillary thyroid carcinoma.
    Onco Targets Ther 2017 11;10:4485-4491. Epub 2017 Sep 11.
    Thyroid and Parathyroid Surgery Center.
    Background: Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients.

    Methods: A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid Surgery Center of West China Hospital of Sichuan University were reviewed. Read More

    Super Scan Caused by Parathyroid Carcinoma Observed Both in(18)F-FDG PET/CT Scan and Tc-99m MDP Bone Scintigraphy.
    Mol Imaging Radionucl Ther 2017 Oct;26(3):116-119
    Çukurova University Faculty of Medicine, Department of Radiology, Adana, Turkey.
    Super scan is a well-known finding described in skeletal scintigraphy characterized by uniform symmetrically increased radiopharmaceutical uptake by bones and consequently diminished renal parenchymal activity. Sy et al. hypothesized that the faint visualization of renal cortex in bone scintigraphy might be the result of increased uptake of radiopharmaceutical by pathologic bones and reduced phosphate excretion. Read More

    Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing.
    BMC Med Genet 2017 Oct 2;18(1):106. Epub 2017 Oct 2.
    Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeing2-ro, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
    Background: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant hereditary disorder characterized by the presence of endocrine tumors affecting the parathyroid, pancreas, and pituitary. A heterozygous germline inactivating mutation in the MEN1 gene (first hit) may be followed by somatic loss of the remaining normal copy or somatic mutations in the MEN1 gene (second hit). Whole-exome sequencing has been successfully used to elucidate the mutations associated with the different types of tumors. Read More

    Evaluation of clinical significance and risk factors of incidental parathyroidectomy due to thyroidectomy: A single-center retrospective clinical study.
    Medicine (Baltimore) 2017 Sep;96(39):e8175
    Department of General Surgery, Beijing Chaoyang Hospital Affiliated Capital Medical University, Beijing, China.
    We assessed the clinical significance and risk factors of incidental parathyroidectomy during total thyroidectomy with or without central neck dissection or subtotal thyroidectomy.Retrospective analysis of clinical and pathological features of 548 consecutive thyroidectomy cases was compared by grouping into inadvertent resection (IR, n = 86) with IR of parathyroid glands, non-IR (n = 462) without, and then into postoperative hypoparathyroidism (PH, n = 140) with PH and non-PH (n = 408) without.Two hundred ninety-eight patients had total thyroidectomy and 250 had subtotal thyroidectomy. Read More

    Risk factors of hypoparathyroidism following total thyroidectomy with central lymph node dissection.
    Medicine (Baltimore) 2017 Sep;96(39):e8162
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
    The risk factors of hypoparathyroidism after total thyroidectomy (TT) with central lymph node dissection (CND) have not been completely defined. The aim of the study was to evaluate the risk factors of hypoparathyroidism after the surgery.We retrospectively reviewed our patients who underwent TT and CND (including lateral lymph node dissection) for thyroid carcinoma between January 2013 and June 2016. Read More

    Endocrine and neuroendocrine cytopathology.
    Minerva Endocrinol 2017 Sep 25. Epub 2017 Sep 25.
    Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
    Cytology is an easily accessible, cost-effective and safe procedure for the initial evaluation of most endocrine/neuroendocrine lesions. Both fine-needle aspiration cytology and exfoliative cytology have shown good sensitivity and specificity in detecting endocrine/neuroendocrine benign proliferations and malignancies. Thanks to its utility for early diagnosis, cytology has contributed to the decline in mortality of endocrine/neuroendocrine neoplasms. Read More

    Parathyroid carcinoma: a clinical and genetic perspective.
    Minerva Endocrinol 2017 Sep 25. Epub 2017 Sep 25.
    Endrocrine Unit 2, University Hospital of Pisa, Pisa, Italy.
    Parathyroid carcinoma (PC) is a rare neoplasia difficult to diagnose preoperatively. It mainly occurs as a sporadic disease but also as part of familial PHPT. At variance with patients with the benign counterpart, the phenotype of these patients is characterized by a severe primary hyperparathyroidism (PHPT). Read More

    Second generation of familial nonmedullary thyroid carcinoma: A meta-analysis on the clinicopathologic features and prognosis.
    Eur J Surg Oncol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, Chendu 610041, PR China. Electronic address:
    Whether the second generation of parent/offspring type familial nonmedullary thyroid carcinoma (FNMTC) is more aggressive and has worse prognosis than their first generation counterpart is controversial. To evaluate the clinicopathologic features and prognosis of the second generation via a comparison between the two groups, We searched three databases (PubMed, EMBASE and the Cochrane library) to review studies published before November 25, 2016. All original studies comparing the clinicopathologic features and prognosis in the first generation of parent/offspring type FNMTC with its second generation counterpart were included. Read More

    Health-related quality-of-life assessment in surgical patients with papillary thyroid carcinoma: A single-center analysis from Mainland China.
    Medicine (Baltimore) 2017 Sep;96(38):e8070
    aThyroid and Parathyroid Surgery Center bHealth and Management Center, West China Hospital of Sichuan University, Chengdu, China.
    Even with a favorable prognosis, the health-related quality of life (HRQoL) of papillary thyroid carcinoma (PTC) patients remains unclear and conflicting. Thus, in the present study, we compared the HRQoL of PTC patients with that of the general population (GP).The study was performed in our thyroid and parathyroid surgery department, and 186 PTC patients who had undergone thyroidectomy were included. Read More

    [Multiple endocrine neoplasia].
    Dtsch Med Wochenschr 2017 Sep 8;142(18):1379-1389. Epub 2017 Sep 8.
    Multiple endocrine neoplasia type 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types, in MEN1 parathyroid tumors, pituitary tumors, and pancreas tumors, in MEN2 medullary thyroid carcinoma, pheochromocytoma, and parathyroid tumors. The autosomal dominant inherited tumor syndromes are caused by mutations in the MEN1 gene, a tumor suppressor gene, and mutations in the RET gene, an activated oncogene, in MEN2. Read More

    Osteitis fibrosa cystica-a forgotten radiological feature of primary hyperparathyroidism.
    Endocrine 2017 Nov 12;58(2):380-385. Epub 2017 Sep 12.
    Department of Medicine, Endocrinology Division, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
    Although bone disease and stone disease are the universally accepted classical manifestations of primary hyperparathyroidism, clinical parathyroid bone disease is rarely seen today in the United States (<5% of patients) and Western Europe. Nevertheless, in a given patient, classical skeletal involvement can be the first sign of primary hyperparathyroidism, but not recognized because it is not usually included, anymore, in the differential diagnosis of this manifestation of skeletal disease. We describe four cases of primary hyperparathyroidism in which the first clinical manifestation of the disease was a pathological fracture that masqueraded as a malignancy. Read More

    Parathyroid Carcinoma in Patients that Have Undergone Surgery for Primary Hyperparathyroidism.
    In Vivo 2017 Sep-Oct;31(5):925-930
    Third Department of Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic
    Background/aim: Parathyroid carcinoma is a rare clinical entity, which represents one of the main reasons, why surgery should be performed in specialized centres. Preoperatively, it is very difficult to distinguish between benign and malignant hyperparathyroidism.

    Patients And Methods: During the years 1996-2016, we performed 2,220 operations in 2,075 patients with a diagnosis of primary hyperparathyroidism. Read More

    Molecular genetics of syndromic and non-syndromic forms of parathyroid carcinoma.
    Hum Mutat 2017 Dec 25;38(12):1621-1648. Epub 2017 Sep 25.
    Radcliffe Department of Medicine, Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.
    Parathyroid carcinoma (PC) may occur as part of a complex hereditary syndrome or an isolated (i.e., non-syndromic) non-hereditary (i. Read More

    Differentiation of the Follicular Variant of Papillary Thyroid Carcinoma From Classic Papillary Thyroid Carcinoma: An Ultrasound Analysis and Complement to Fine-Needle Aspiration Cytology.
    J Ultrasound Med 2017 Sep 7. Epub 2017 Sep 7.
    Departments of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taoyuan Hsien, Taiwan.
    Objectives: It is difficult to establish a diagnosis of the follicular variant of papillary thyroid carcinoma (PTC) using fine-needle aspiration cytology (FNAC). Preoperative features on ultrasound (US) imaging are different between follicular PTC and classic PTC. This study developed a risk score system to differentiate follicular PTC from classic PTC and to correlate the risk score of follicular PTC with its FNAC categories and pathologic features. Read More

    Multiple Myeloma Presenting as Massive Amyloid Deposition in a Parathyroid Gland Associated with Amyloid Goiter: A Medullary Thyroid Carcinoma Mimic on Intra-operative Frozen Section.
    Head Neck Pathol 2017 Sep 6. Epub 2017 Sep 6.
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO, USA.
    Clinical examples of amyloid deposition in parathyroid glands are exceedingly rare and usually present as an incidental finding in a patient with amyloid goiter. Here, we present the first histologically documented case of parathyroid amyloid deposition that presented as a mass. The patient did not have hyperparathyroidism. Read More

    POSTOPERATIVE TRANSIENT HYPOPARATHYROIDISM: INCIDENCE AND RISK FACTORS - A SOUTH AFRICAN PERSPECTIVE.
    S Afr J Surg 2017 Sep;55(3):74
    Groote Schuur Hospital.
    Background: There is limited published data on the incidence and risk factors for developing postoperative hypoparathyroidism (POHP) in the South African setting.

    Method: All patients who underwent a total thyroidectomy or completion thyroid lobectomy at an academic referral centre from January 2010 to December 2015 were included in this study. Data reviewed included post-operative parathyroid hormone (iPTH) level within 24 hours of surgery, age, gender, type of operation and lymphadenectomy if performed, size and weight of thyroid glands resected, final histological diagnosis, presence of extracapsular extension of carcinomas, number of lymph nodes resected, and the number of parathyroids present in the histology specimen. Read More

    Metastases to the Parathyroid Glands: A Comprehensive Literature Review of 127 Reported Cases.
    Head Neck Pathol 2017 Sep 5. Epub 2017 Sep 5.
    Department of Pathology, Woodland Hills Medical Center, Southern California Permanente Medical Group, 5601 De Soto Avenue, Woodland Hills, CA, 91365, USA.
    Metastases to the head and neck organs are uncommon, potentially representing the initial presentation of an occult malignancy. Single case reports and small series report metastases to the parathyroid gland, but there is no large review of the literature on secondary tumors involving the parathyroid glands. A review of the English literature between 1950 and 2017 was performed of all metastases or secondary involvement of the parathyroid glands. Read More

    Inflammatory infiltrates in parathyroid tumors.
    Eur J Endocrinol 2017 Dec 30;177(6):445-453. Epub 2017 Aug 30.
    Department of Oncology-PathologyKarolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, Stockholm, Sweden.
    Context: Inflammatory infiltrates are sometimes present in solid tumors and may be coupled to clinical behavior or etiology. Infectious viruses contribute to tumorigenesis in a significant fraction of human neoplasias.

    Objective: Characterize inflammatory infiltrates and possible viral transcription in primary hyperparathyroidism. Read More

    [Hypercalcemic crisis and hypocalcemic tetany].
    Internist (Berl) 2017 Oct;58(10):1029-1036
    Abteilung Innere Medizin I und Klinische Chemie, Sektion Osteologie, Medizinische Universitätsklinik Heidelberg, INF 410, 69120, Heidelberg, Deutschland.
    A serum calcium level >3.5 mmol/l together with clinical symptoms such as muscle weakness, fatigue, nausea, vomiting, pancreatitis or even coma are characteristic for a hypercalcemic crisis (HC). Primary hyperparathyroidism (1HPT) and malignancy-associated hypercalcemia are the most frequent causal diseases for a HC. Read More

    Simultaneous Incidental Parathyroid Carcinoma and Intrathyroid Parathyroid Gland in Suspected Renal Failure Induced Hyperparathyroidism.
    Surg J (N Y) 2017 Jan 28;3(1):e23-e24. Epub 2017 Feb 28.
    Department of Otolaryngology - Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
    Hyperparathyroidism is a common disorder affecting more than hundreds of thousands of people annually. While most commonly secondary to an adenoma, it may also arise from four-gland hyperplasia or malignancy. In the case of primary hyperparathyroidism, the number of glands involved may be unknown prior to surgery. Read More

    The Sestamibi Paradox: Improving Intraoperative Localization of Parathyroid Adenomas.
    Am Surg 2017 Aug;83(8):832-835
    Accurate localization of parathyroid adenomas allows for minimally invasive parathyroidectomy. This results in a shorter length of stay and increased patient satisfaction. Preoperative Technetium (99mTc) sestamibi scans accurately localize parathyroid adenomas in 70 to 85 per cent of cases. Read More

    [Parathyroid carcinoma: about a case and review of the literature].
    Pan Afr Med J 2017 5;27:85. Epub 2017 Jun 5.
    Service ORL et CCF au CHU Fattouma Bourguiba, Monastir, Tunisie.
    Parathyroid carcinoma is a very rare malignant tumor of the parathyroid gland. Clinically, this cancer is characterized by the presence of severe primary hyperparathyroidism. Diagnosis is based on histological examination but is not always easy. Read More

    Evaluating the effectiveness of prophylactic central neck dissection with total thyroidectomy for cN0 papillary thyroid carcinoma: An updated meta-analysis.
    Eur J Surg Oncol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, PR China. Electronic address:
    Background: The effectiveness of prophylactic central neck dissection (pCND) following total thyroidectomy (TT) in patients with clinical node-negative (cN0) papillary thyroid carcinoma (PTC) is still controversial. The aim of this meta-analysis is to evaluate the outcome of pCND and to provide quantitative evidence.

    Method: A detailed literature search of PubMed, EMBASE, ClinicalTrails. Read More

    Radioguided surgery in primary hyperparathyroidism: Results and correlation with intraoperative histopathologic diagnosis.
    Acta Otorrinolaringol Esp 2017 Aug 11. Epub 2017 Aug 11.
    Servicio de Endocrinología, Hospital San Pedro de Alcántara , Cáceres, España.
    Introduction And Objectives: Radioguided surgery is a minimally invasive surgical technique for the treatment of primary hyperparathyroidism. The goals of our study were to evaluate the rate of success and compare the results with intraoperative histological analysis.

    Methods: We retrospectively studied 84 patients with primary parathyroidism who had undergone radioguided surgery. Read More

    Long-Term Outcomes of Lateral Neck Dissection in Patients with Recurrent or Persistent Well-Differentiated Thyroid Cancer.
    Thyroid 2017 Oct 14;27(10):1291-1299. Epub 2017 Sep 14.
    1 Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center , Houston, Texas.
    Background: Well-differentiated thyroid carcinoma (WDTC) has a high predilection for regional metastatic spread. Rates for WDTC lateral neck recurrence are reported to be as high as 24% in patients after initial thyroidectomy, lateral neck surgery, and adjuvant radioactive (RAI) iodine treatment. The objective of the study was to evaluate the efficacy, safety, and long-term outcome of comprehensive lateral neck dissection (LND) of levels II-V for recurrent or persistent WDTC in a tertiary referral center. Read More

    [Pay attention to the standardized application of new techniques in surgical treatment of thyroid disease].
    Zhonghua Wai Ke Za Zhi 2017 Aug;55(8):561-565
    Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
    The continuous development and application of new technology in thyroid surgery has promoted the rapid improvement of thyroid surgery. New technology in the field of thyroid surgery has developed rapidly. The application of neural monitoring technology has enabled the thyroid surgery to enter an accurate era. Read More

    In situ preservation of the inferior parathyroid gland during central neck dissection for papillary thyroid carcinoma.
    Br J Surg 2017 Oct 7;104(11):1514-1522. Epub 2017 Aug 7.
    Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Background: Postoperative hypocalcaemia due to dysfunction of the parathyroid glands is the most common complication after total thyroidectomy plus central neck dissection (CND). There is a lack of surgical techniques described to help preserve the inferior parathyroid gland in situ during CND. The objective of this study was to introduce the 'TBP layer' (layer of thymus-blood vessel-inferior parathyroid gland) concept for preserving the inferior parathyroid gland in situ during CND, and to evaluate its effectiveness. Read More

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