13,321 results match your criteria Parathyroid Carcinoma


Parathyroid carcinoma coexisting with multiple parathyroid adenomas: a case report.

Endocr J 2020 May 30. Epub 2020 May 30.

Kusatsu General Hosipital, Otolaryngology Head and Neck Thyroid Surgery, Shiga 525-8585, Japan.

Primary hyperparathyroidism is usually caused by parathyroid adenoma; however, parathyroid carcinoma is a rare cause. We report a rare case of 74-year-old female of primary hyperparathyroidism caused by parathyroid carcinoma (PC) and coexisting multiple parathyroid adenomas. She was referred to our hospital for primary hyperparathyroidism and a suspected thyroid tumor. Read More

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http://dx.doi.org/10.1507/endocrj.EJ20-0139DOI Listing

New and future perspectives for parathyroid carcinoma.

Endocr Relat Cancer 2020 May 1. Epub 2020 May 1.

M Brandi, Surgery and Translational Medicine, University of Florence, Firenze, Italy.

This report summarizes published data on parathyroid cancer, with the inclusion of topics discussed at the 16th International Workshop on Multiple Endocrine Neoplasia (MEN2019), 27-29 March 2019, Houston, TX, USA. An expert panel on parathyroid cancer was constituted by the steering committee to address key questions in the field. The objectives were to recap open forum discussion of interested parties from multiple disciplines. Read More

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http://dx.doi.org/10.1530/ERC-20-0018DOI Listing

[Hypoparathyroidism treated with recombinant human parathyroid hormone [rhPTH(1-84)]].

Medicina (B Aires) 2020 ;80(3):289-291

Servicio de Endocrinología, Clínica Universitaria Reina Fabiola, Córdoba, Argentina.

Hypoparathyroidism (HypoPT) is a rare disease characterized by low calcium and inappropriately low circulating parathormone levels. We present the case of a 25-year-old high-performance athlete male, with history of HypoPT after total thyroidectomy for papillary thyroid carcinoma (T3 N1b M0) two years before, who was referred to our clinic for symptomatic hypocalcemia. The patient reported serum calcium average levels of 7mg%, presented symptoms of hypocalcemia at rest and had multiple hospital admissions. Read More

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January 2020

Multiple concurrent atypical parathyroid adenomas: a rare occurrence.

BMJ Case Rep 2020 May 20;13(5). Epub 2020 May 20.

Otolaryngology, Surrey and Sussex Healthcare NHS Trust, Redhill, UK.

We present a case of an 80-year-old patient with three concurrent multiple atypical parathyroid adenomas. The patient was managed with bilateral parathyroid exploration and concurrent parathyroidectomy. Postoperative recovery was uneventful. Read More

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http://dx.doi.org/10.1136/bcr-2020-234421DOI Listing

Synchronous symptomatic parathyroid carcinoma and parathyroid adenoma with incidental follicular thyroid carcinoma.

Ann R Coll Surg Engl 2020 May 21:e1-e4. Epub 2020 May 21.

National University Hospital, Singapore.

We describe the case of an 89-year old Caucasian woman admitted with confusion and severe clinical manifestations of acute hypercalcaemia. There was no history suggestive of any malignancy and initial management included correction of the hypercalcaemia with intravenous fluid therapy. Sestamibi parathyroid scintigraphy and neck ultrasonography demonstrated a 4cm left-sided thyroid lesion and a nearly 2cm right-sided thyroid lesion. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0101DOI Listing

Ultrasonic scalpel with knot tying protects parathyroid function for total thyroidectomy with central neck dissection.

Gland Surg 2020 Apr;9(2):192-199

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: Hypoparathyroidism might be due to collateral thermal injury induced by harmonic scalpel (HS) after total thyroidectomy (TT) with central neck dissection (CND). The current study aimed to evaluate whether a clamp and tie (CAT) technique used to preserve parathyroid glands in situ could reduce damage to parathyroid function in HS patients undergoing TT plus unilateral or bilateral CND.

Methods: Medical records of 537 HS-operated patients with papillary thyroid carcinoma (PTC) undergoing TT plus unilateral or bilateral CND were retrospectively evaluated. Read More

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http://dx.doi.org/10.21037/gs.2020.01.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225474PMC

Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma.

Int J Endocrinol 2020 27;2020:2080797. Epub 2020 Apr 27.

Division of Medical Genetics, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo (FG), Italy.

Objective: Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or predictable. Up to date only two cases of atypical adenoma were found associated to a MEN1 syndrome, and only one was proved to carry a pathogenic variant of the MEN1 gene.

Design: We report the clinical, histologic, and molecular findings of a 44-year-old woman, presenting with a histologically proved atypical parathyroid adenoma with an apparent aggressive behaviour. Read More

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http://dx.doi.org/10.1155/2020/2080797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201480PMC

First ever case report of co-occurrence of hobnail variant of papillary thyroid carcinoma and intrathyroid parathyroid adenoma in the same thyroid lobe.

Int J Surg Case Rep 2020 May 5;70:40-52. Epub 2020 May 5.

Department of General Surgery, Hamad General Hospital, Doha, Qatar.

Introduction: The hobnail variant of papillary thyroid cancer (PTC) is rare. Intrathyroid parathyroid adenoma (ITPA) is also rare. Co-ocurrence of PTC and ITPA in the same thyroid lobe is extremely rare. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218145PMC

Effects of active localization and vascular preservation of inferior parathyroid glands in central neck dissection for papillary thyroid carcinoma.

World J Surg Oncol 2020 May 13;18(1):95. Epub 2020 May 13.

Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Street, Gulou District, Nanjing, 210011, NO, China.

Background: The purpose of present study is to assess the effects of active localization and vascular preservation of inferior parathyroid glands in central neck dissection (CND) for papillary thyroid carcinoma (PTC).

Methods: A classification of IPGs according to their location and vascular features was developed, and, based on this classification, a CND procedure was designed, and IPGs and their vascular were actively localized and strategically preserved. A total of 197 patients with PTC who underwent a total thyroidectomy and concomitant CND were enrolled. Read More

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http://dx.doi.org/10.1186/s12957-020-01867-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222446PMC

A simple, efficient, and safe way of finding recurrent laryngeal nerve beneficial for PTC patients.

Medicine (Baltimore) 2020 May;99(19):e20138

Department of Thyroid and Vascular Surgery.

Background: More surgeons have known the importance of parathyroid grand and recurrent laryngeal nerve protection in the surgery, but there is still plenty of scope to improve the surgical techniques. This study aims at investigating whether the improved method of finding recurrent laryngeal nerve (RLN) can protect parathyroid grand and RLN.

Methods: One hundred fifty-eight patients were enrolled and divided randomly into the test and control group according to different methods of finding RLN in the surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000020138DOI Listing

Is dual-phase SPECT/CT with 99mTc-sestamibi better than single-phase SPECT/CT for lesion localization in patients with hyperparathyroidism?

Medicine (Baltimore) 2020 May;99(19):e19989

Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine.

This study aimed to establish an optimal protocol for Tc-sestamibi parathyroid imaging for lesion localization in patients with hyperparathyroidism (HPT).We retrospectively enrolled 35 consecutive patients who underwent dual-phase (at 10 minutes and 120 minutes) Tc-sestamibi parathyroid scintigraphy with single-photon emission computed tomography (SPECT)/computed tomography (CT). Twenty seven patients had primary HPT, and 8 had secondary or tertiary HPT. Read More

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http://dx.doi.org/10.1097/MD.0000000000019989DOI Listing

Pathological evaluation of the accuracy of a fluorescence spectroscopy system for detecting parathyroid glands.

Eur Arch Otorhinolaryngol 2020 May 6. Epub 2020 May 6.

Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-Ku, Sapporo, 060-8638, Japan.

Purpose: A fluorescence-based technique for the detection of parathyroid glands (PGs) intraoperatively was previously reported. The technique was based on the phenomenon in which PGs emit autofluorescence when exposed to near-infrared light and we undertook an evaluation to consider the pathological accuracy of the method.

Methods: The study comprised 17 patients (18 specimens) who underwent thyroid surgery at Kushiro City General Hospital between November 2018 and June 2019. Read More

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http://dx.doi.org/10.1007/s00405-020-06011-wDOI Listing

Primary hyperparathyroidism as first manifestation in MEN 2A: an international multicenter study.

Endocr Connect 2020 May 1. Epub 2020 May 1.

J Mathiesen, Department of ORL Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Objective: Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations, and have been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence of cases presenting with PHPT as first manifestation among MEN 2A index cases and to characterize the former cases. Read More

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http://dx.doi.org/10.1530/EC-20-0163DOI Listing

Pitfalls of using denosumab preoperatively to treat refractory severe hypercalcaemia.

BMJ Case Rep 2020 Apr 28;13(4). Epub 2020 Apr 28.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

A 40-year-old man, with a history of metastatic parathyroid carcinoma, status post primary tumour resection and lung metastasectomy, was hospitalised for persistent severe hypercalcaemia and elevated parathyroid hormone levels despite conventional management and escalating doses of cinacalcet. A single dose (120 mg) of denosumab was given and his calcium level plummeted from 14.8 mg/dL to 5. Read More

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http://dx.doi.org/10.1136/bcr-2019-233665DOI Listing

Hurthle Cell Adenoma with Micro-Papillary Carcinoma and Parathyroid Adenoma in a Transplant Recipient with Graft Failure: A Case Report.

Gulf J Oncolog 2020 Jan;1(32):66-70

Kuwait Cancer Control Center, Kuwait.

Chronic immunosuppression is known to cause an increased risk of cancers in organ transplant recipients leading to the rise in morbidity and mortality among these patients. Recent studies have observed that thyroid lesions are more frequently encountered in kidney transplant recipients. A 45-year-old woman with history of chronic hypertension, kidney transplant and graft failure, was admitted for assessment for a second renal transplant and detected to have a thyroid nodule by ultrasound (US). Read More

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January 2020

Comparison of Lobectomy and Total Thyroidectomy in Unilateral Papillary Thyroid Microcarcinoma Patients with Ipsilateral Lateral Lymph Node Metastasis Without Gross Extrathyroidal Extension.

World J Surg 2020 Apr 23. Epub 2020 Apr 23.

Center of Thyroid and Parathyroid, Department of Thyroid, Parathyroid, Breast and Hernia Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China.

Background: Lateral lymph node metastasis (LLNM) occurs in a few of papillary thyroid microcarcinoma (PTMC) cases by the time of diagnosis. Total thyroidectomy (TT) is recommended in the 2015 American Thyroid Association guidelines as the initial surgical procedure for thyroid carcinoma patients with clinically apparent cervical lymph node metastasis. However, none of the controlled studies have focused on the proper extent of surgery for patients who have PTMC with concomitant LLNM without gross extrathyroidal extension (ETE). Read More

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http://dx.doi.org/10.1007/s00268-020-05514-1DOI Listing
April 2020
2.642 Impact Factor

Ectopic mediastinal parathyroid carcinoma in a patient with end-stage renal disease.

Kidney Res Clin Pract 2020 Apr 23. Epub 2020 Apr 23.

Division of Nephrology, Department of Internal Medicine, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan, Republic of Korea.

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http://dx.doi.org/10.23876/j.krcp.20.023DOI Listing

Fine-needle aspiration with rapid parathyroid hormone assay to identify parathyroid gland in thyroidectomy.

Medicine (Baltimore) 2020 Apr;99(16):e19840

Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai, China.

To determine the levels of parathyroid hormone (PTH) in the fluids of various tissues for identification of parathyroid glands during thyroidectomy.Our study comprised 31 patients with thyroid cancer who underwent lobectomy with central compartment dissection at our hospital from October 2014 to February 2015. A total of 186 tissue samples, including 28 from parathyroid glands and 158 from non-parathyroid tissues, were obtained during the operations. Read More

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http://dx.doi.org/10.1097/MD.0000000000019840DOI Listing

Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images.

Ann Diagn Pathol 2020 Mar 3;46:151492. Epub 2020 Mar 3.

Department of Endocrinology and Metabolism, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Purpose: In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated.

Methods: In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151492DOI Listing

An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature.

Case Rep Endocrinol 2020 31;2020:2128093. Epub 2020 Mar 31.

Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, México City 14000, Mexico.

Synchronous parathyroid and papillary thyroid carcinoma are extremely rare. To our knowledge, only 15 cases have been reported in the last four decades. We describe a 50-year-old female without significant past medical or family history and no previous trauma presented with left heel pain that prompted her to seek medical attention. Read More

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http://dx.doi.org/10.1155/2020/2128093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150727PMC

Novel Findings on SPECT-CT Tc-99 Sestamibi Imaging for Primary Hyperparathyroidism.

J Surg Res 2020 Apr 11;252:216-221. Epub 2020 Apr 11.

Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

Background: The addition of SPECT-CT to Tc-99 sestamibi has become a valuable tool for parathyroid localization in primary hyperparathyroidism (PHP). However, the enhanced sensitivity of this test can lead to unexpected and significant findings. We sought to identify the frequency and types of nonparathyroid detections by SPECT-CT. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.014DOI Listing

[Giant parathyroid adenoma: a rare cause of severe hypercalcemia].

G Ital Nefrol 2020 Apr 9;37(2). Epub 2020 Apr 9.

Sezione di Nefrologia, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Universitario & Scuola di Specializzazione in Nefrologia, Università di Catania, Catania, Italia.

We report the case of a 37-year-old woman that developed severe hypercalcemia due to a parathyroid gland mass. After the initial medical treatment, only a minimal reduction of calcemia was observed and her clinical condition worsened; thus, she required continuous renal replacement therapy (CRRT) that resulted in the normalization of calcium serum level. She then underwent a left thyroid lobectomy with exeresis of the associated parathyroid glands; the histological diagnosis revealed a giant parathyroid adenoma (GPA). Read More

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Evocalcet in patients with primary hyperparathyroidism: an open-label, single-arm, multicenter, 52-week, dose-titration phase III study.

J Bone Miner Metab 2020 Apr 9. Epub 2020 Apr 9.

Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.

Introduction: Primary hyperparathyroidism (PHPT) is caused by parathyroid adenoma, primary parathyroid hyperplasia, or parathyroid carcinoma. For some patients with PHPT controlling serum calcium levels is critical.

Materials And Methods: We conducted an open-label, single-arm, 52-week, phase III study in Japanese patients with hypercalcemia due to PHPT to demonstrate efficacy and safety of evocalcet, a new calcimimetic. Read More

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http://dx.doi.org/10.1007/s00774-020-01097-yDOI Listing

[Effect of perioperative application of glucocorticoid on postoperative hypoparathyroidism and hypocalcemia in patients with total thyroidectomy plus central compartment dissection].

Authors:
J H Li X H Chen

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Mar;55(3):249-253

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To evaluate the effect of glucocorticoid used in perioperative period of total thyroidectomy (TT) plus central compartment lymph node dissection (CCLND) or combining with lateral neck dissection on postoperative hypoparathyroidism (HPT) and hypocalcemia (HPC). The data of 117 patients with papillary thyroid carcinoma (PTC) undergone the surgeries in Tongren Hospital between Nov 2015 and Mar 2017 were retrospectively analyzed. There were 36 males and 81 females, and their ages ranged from 21 to 74 years old, average age of 47. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2020.03.011DOI Listing

Hyperparathyroidism Jaw Tumor Syndrome Presenting as Recurrent Femur Fractures in a Young Woman; a Rare Presentation of a Rare Disease.

Case Rep Endocrinol 2020 16;2020:9298147. Epub 2020 Mar 16.

Endocrinology Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Primary hyperparathyroidism usually occurs secondary to parathyroid adenoma, multiglandular hyperplasia, or parathyroid carcinoma. The patients usually present with incidentally discovered high calcium level and systemic or skeletal manifestations. In young patients with primary hyperparathyroidism, familial syndromes including multiple endocrine neoplasia types 1, 2, and 4 and hyperparathyroidism jaw tumor syndrome should be considered. Read More

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http://dx.doi.org/10.1155/2020/9298147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102458PMC

Intrapericardial parathyroid carcinoma: a case report.

Endocrine 2020 Apr 4. Epub 2020 Apr 4.

Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, 100020, Beijing, China.

Purpose: Ectopic parathyroid glands are thought to be the cause of a significant portion of failed primary surgery for hyperparathyroidism. Parathyroid carcinoma (PTCA) is a rare malignant tumor, and ectopic PTCA is a particularly unusual situation. Here, we describe, for the first time, a case of intrapericardial PTCA. Read More

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http://dx.doi.org/10.1007/s12020-020-02283-8DOI Listing
April 2020
3.527 Impact Factor

Pituitary adenomas in the setting of multiple endocrine neoplasia type 1: a single-institution experience.

J Neurosurg 2020 Apr 3:1-7. Epub 2020 Apr 3.

Departments of1Neurological Surgery.

Objective: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal-dominant tumor disorder characterized by the development of pituitary tumors and other endocrine neoplasms. Diagnosis is made clinically based on the development of 2 or more canonical lesions (parathyroid gland, anterior pituitary, and enteropancreatic tumors) or in family members of a patient with a clinical diagnosis of MEN1 and the occurrence of one of the MEN1-associated tumors. The goal of this study was to characterize pituitary tumors arising in the setting of MEN1 at a single institution. Read More

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http://dx.doi.org/10.3171/2020.1.JNS193538DOI Listing

[Acute pancreatitis as an initial manifestation of parathyroid adenoma].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):331-332

Department of Pediatrics, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.

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http://dx.doi.org/10.3760/cma.j.cn112140-20190829-00553DOI Listing

Severe hypercalcaemia of primary hyperparathyroidism: Could giant adenoma be the real culprit rather than carcinoma?

Ann R Coll Surg Engl 2020 May 1;102(5):363-368. Epub 2020 Apr 1.

İzmir Kâtip Çelebi University Atatürk Training and Research Hospital, Turkey.

Introduction: Hypercalcaemic crisis is a rare manifestation of hyperparathyroidism and occurs in 1.6-6% of patients with primary hyperparathyroidism (pHPT). Although such high serum calcium levels (>14mg/dl) are attributed to malignancy, it is also associated with benign disease of the parathyroid glands. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0039DOI Listing

Adult Ectopic Cervical Thymic Tissue in relation to a Parathyroid Adenoma and a Papillary Thyroid Carcinoma: A Report of Two Cases.

Case Rep Otolaryngol 2020 11;2020:9127635. Epub 2020 Mar 11.

Department of Otolaryngology, Maharishi Markandeshwar Institute of Medical Sciences and Research, MMDU, Mullana, Ambala, Haryana, India.

Ectopic cervical thymus is a rare congenital anomaly, which results because of the failure of complete descent of the thymus. They are incidental findings in the young and may disappear during the early years of life; however, they have rarely been described in adults. Some of them may undergo hyperplasia or neoplastic transformation and become visible or cause symptoms. Read More

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http://dx.doi.org/10.1155/2020/9127635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086421PMC

Immunocyte density in parathyroid carcinoma is correlated with disease relapse.

J Endocrinol Invest 2020 Mar 26. Epub 2020 Mar 26.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Purpose: Parathyroid carcinoma (PC) is an endocrine malignancy with a poor prognosis. The tumour immune microenvironment is a critical factor influencing the outcomes of multiple cancer types. However, knowledge of the immune microenvironment in PC remains limited. Read More

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http://dx.doi.org/10.1007/s40618-020-01224-6DOI Listing

Parathyroid Carcinoma: An Up-to-Date Retrospective Multicentric Analysis.

Int J Endocrinol 2020 6;2020:7048185. Epub 2020 Mar 6.

Department of Endocrinology, Diabetes and Metabolism, "Santa Croce e Carle" Hospital, Cuneo 12100, Italy.

Parathyroid carcinoma (PC) is a rare disease responsible for about 1% of primary hyperparathyroidism (PHPT) cases. PC usually has an indolent course, tough to differentiate from the benign causes of PHPT, and the only certain diagnosis is histologic. The gold standard surgical treatment is the en bloc resection associated with the homolateral thyroid loboistmectomy. Read More

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http://dx.doi.org/10.1155/2020/7048185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079239PMC

Association of the Preoperative Inflammation-Based Scores with TNM Stage and Recurrence in Patients with Papillary Thyroid Carcinoma: A Retrospective, Multicenter Analysis.

Cancer Manag Res 2020 11;12:1809-1818. Epub 2020 Mar 11.

Department of Breast and Thyroid Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Background: The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI) have been reported to be prognostic biomarkers in various cancers. Our study evaluated whether the preoperative NLR, PLR and PNI predicted tumor-node-metastasis (TNM) stage and recurrence in papillary thyroid carcinoma (PTC) patients.

Methods: A total of 1873 patients with PTC from 9 centers in mainland China were retrospectively assessed. Read More

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http://dx.doi.org/10.2147/CMAR.S239296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073431PMC

Parathyroid Carcinoma Shown on 99mTc-Sestamibi Parathyroid SPECT/CT Scan in a Pediatric Patient.

Clin Nucl Med 2020 Jun;45(6):480-482

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.

A 10-year-old boy presented with back pain. Tc-methylene diphosphonate bone scan demonstrated the sign of metabolic bone disease, suspected due to hyperparathyroidism. Tc-sestamibi parathyroid SPECT/CT demonstrated focal lesion in the lower pole of the right lobe. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002998DOI Listing
June 2020
3.931 Impact Factor

[Primary hyperparathyroidism in Russia according to the registry].

Probl Endokrinol (Mosk) 2019 Nov 23;65(5):300-310. Epub 2019 Nov 23.

Endocrinology Research Centre.

Background: There are no large-scale epidemiological studies on primary hyperparathyroidism (PHPT) in Russia. The high prevalence of the disease, the high risk of disability and death in this cohort of patients requires the study of the epidemiological and clinical structure of PHPT to determine the extent of medical care.

Aim: Evaluate the frequency of PHPT detection and characterize its clinical forms in Russia using an online registry. Read More

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http://dx.doi.org/10.14341/probl10126DOI Listing
November 2019

Unexpected rare metastases of renal cell carcinoma.

World J Nucl Med 2020 Jan-Mar;19(1):89-91. Epub 2020 Jan 14.

Department of Surgery, Penang Adventist Hospital, Pulau Pinang, Malaysia.

Renal cell carcinomas (RCCs) commonly metastasize to the lungs and bones and rarely to the parathyroid, maxillary sinus, and adrenals. It is indeed very rare to have these all these metastases occurring simultaneously in an individual. We share a case of 67-year-old woman provisionally treated for parathyroid carcinoma but subsequently found to actually have metastatic RCC to the left maxillary sinus, parathyroid, lungs, and adrenals on F-fluorodeoxyglucose positron emission tomography-computed tomography. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_14_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067128PMC
January 2020

Incidental breast lesion detected by technetium-99m sestamibi scintigraphy in a patient with primary hyperparathyroidism.

World J Nucl Med 2020 Jan-Mar;19(1):69-71. Epub 2019 Jul 23.

Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Nuclear scintigraphy is functional imaging and can be combined with anatomical imaging to improve diagnostic yield. Detection of parathyroid lesion by technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) can facilitate an appropriate operative approach in a patients with primary hyperparathyroidism. Tc-99m MIBI is concentrated in highly cellular or metabolically active tissues, which have abundant mitochondria. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_5_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067130PMC

[Unexpected Postoperative Diagnosis of Parathyroid Carcinoma].

Praxis (Bern 1994) 2020 ;109(4):291-296

Abteilung Endokrinologie, Diabetologie und klinische Ernährung, Luzerner Kantonsspital Luzern.

Unexpected Postoperative Diagnosis of Parathyroid Carcinoma Parathyroid carcinoma is a rare endocrine malignancy. It typically presents itself with similar clinical features as seen in patients with primary hyperparathyroidism caused by a parathyroid adenoma. Due to overlapping clinical manifestations, imaging findings and pathological characteristics, the differentiation between benign and malignant parathyroid disease poses a diagnostic challenge, especially prior to surgery. Read More

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http://dx.doi.org/10.1024/1661-8157/a003388DOI Listing
January 2020

INCIDENCE, RISK FACTORS, AND CLINICAL IMPLICATIONS OF DELAYED HYPOPARATHYROIDISM ON POSTOPERATIVE DAY TWO FOLLOWING TOTAL THYROIDECTOMY FOR PAPILLARY THYROID CARCINOMA.

Endocr Pract 2020 Mar 16. Epub 2020 Mar 16.

Division of Breast & Thyroid Surgical Oncology, Department of Surgery, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Jungbu-daero 93, Paldal-gu, Suwon-si, Gyeonggi-do 442-723, Republic of Korea.

This study aimed to investigate the incidence rates, risk factors, and clinical implications of delayed hypoparathyroidism on postoperative day two (POD-2) after total thyroidectomy in patients with papillary thyroid carcinoma. This study included 410 patients with normal serum intact parathyroid hormone (iPTH) and calcium levels on POD-1 who were classified into two groups according to the presence or absence of delayed hypoparathyroidism on POD-2. Of the 410 patients, 98 experienced delayed hypoparathyroidism on POD-2 (23. Read More

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http://dx.doi.org/10.4158/EP-2019-0544DOI Listing

Incidentally detected primary hyperparathyroidism.

Ann Afr Med 2020 Jan-Mar;19(1):71-72

Department of Radiology, Subharti Medical College, Meerut, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/aam.aam_11_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189877PMC

Severe Primary Hyperparathyroidism Caused by Parathyroid Carcinoma in a 13-Year-Old Child; Novel Findings From HRpQCT.

JBMR Plus 2020 Mar 2;4(3):e10324. Epub 2020 Jan 2.

Department of Pediatrics, Division of Endocrinology Toronto Canada.

Primary hyperparathyroidism is a condition that occurs infrequently in children. Parathyroid carcinoma, as the underlying cause of hyperparathyroidism in this age group, is extraordinarily rare, with only a few cases reported in the literature. We present a 13-year-old boy with musculoskeletal pain who was found to have brown tumors from primary hyperparathyroidism caused by parafibromin-immunodeficient parathyroid carcinoma. Read More

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http://dx.doi.org/10.1002/jbm4.10324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059826PMC

[A Case of Giant Parathyroid Adenoma].

Gan To Kagaku Ryoho 2019 Dec;46(13):2051-2053

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

A 79-year-old man presenting with general fatigue was admitted to our department. Preoperative laboratory examination indicated primary hyperparathyroidism as the cause of his symptoms, with elevated parathormone and serum calcium levels. Ultrasound and 99mTc-MIBI of the cervical region revealed a giant parathyroid adenoma, sized 4×2. Read More

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December 2019

Risk factors of permanent hypoparathyroidism after total thyroidectomy and central neck dissection for papillary thyroid cancer: a prospective study.

Endokrynol Pol 2020 10;71(2):126-133. Epub 2020 Mar 10.

Department of Endocrine Oncology and Nuclear Medicine, Maria Skłodowska-Curie National Institute of Oncology - National Research Institute, Warsaw, Poland.

Introduction: Inadvertent removal of, or damage to the parathyroid glands in the course of operations on the anterior neck compartment are responsible for over 80% of cases of chronic hypoparathyroidism (HypoPT). This study searched for factors related to the development of permanent HypoPT after total thyroidectomy and central neck lymphadenectomy in patients with thyroid carcinoma.

Material And Methods: In total, 89 of 103 screened patients met the study's criteria and were put under prospective one-year observation. Read More

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http://dx.doi.org/10.5603/EP.a2020.0006DOI Listing

Perioperative Nursing of Patients with Reoperation of Recurrent Parathyroid Carcinoma Invading the Upper Digestive or Respiratory Tract.

Biomed Res Int 2020 20;2020:6946048. Epub 2020 Feb 20.

Department of Otolaryngology Head and Neck Surgery, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: The aim of this study was to summarize the perioperative nursing care of patients with recurrent parathyroid carcinoma.

Methods: A retrospective analysis of 10 patients with recurrent parathyroid carcinoma was performed. The clinical data, diagnosis, treatment process, and nursing process (including clinical nursing intervention of various complications) were analyzed. Read More

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http://dx.doi.org/10.1155/2020/6946048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054761PMC
February 2020

Images in Endocrine Pathology: High-Grade Intrathyroidal Parathyroid Carcinoma with Crooke's Hyalinization.

Endocr Pathol 2020 Jun;31(2):190-194

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/s12022-020-09613-6DOI Listing

Association of rs944289, rs965513, and rs1443434 in TITF1/TITF2 with Risks of Papillary Thyroid Carcinoma and with Nodular Goiter in Northern Chinese Han Populations.

Int J Endocrinol 2020 11;2020:4539747. Epub 2020 Feb 11.

Department of Cardiovascular Center, First Hospital of Jilin University, Changchun 130021, China.

Objective: In this study, we aimed to investigate the associations of three single-nucleotide polymorphisms (SNPs) on TITF1/TITF2 (rs944289, rs965513, and rs1443434) with susceptibility to papillary thyroid carcinoma (PTC) and with nodular goiter (NG) in northern Chinese Han populations.

Methods: We performed a case-control study comprising 861 PTC patients, 562 NG patients, and 896 normal controls (NCs). One TITF1 SNP (rs944289) and two TITF2 SNPs (rs965513 and rs1443434) were genotyped. Read More

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http://dx.doi.org/10.1155/2020/4539747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036112PMC
February 2020
1.515 Impact Factor

[Clinical application of carbon nanoparticles suspension in operation of papillary thyroid carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):165-169

Department of Otorhinolaryngology Head and Neck Surgery,Beijing Friendship Hospital,Capital Medical University.

The aim of this study is to evaluate the application of carbon nanoparticle lymphatic tracer in total thyroidectomy and bilateral Central District's thyroidectomy for papillary thyroid carcinoma. Sixty-four patients with cN0 papillary thyroid carcinoma that primary treated were random divided into two groups: Trial group and control group. Carbon nanoparticles suspension was injected into the thyroid gland of trial group patients. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2020.02.016DOI Listing
February 2020

Neural monitoring in thyroid surgery is here to stay.

Gland Surg 2020 Jan;9(Suppl 1):S43-S46

Division of Thyroid Surgery, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, China-Japan Union Hospital Of Jilin University, Changchun 130000, China.

The iatrogenic injury of the recurrent laryngeal nerve (RLN), more clinically significant than those affecting the external branch of the superior laryngeal nerve (EBSLN), constitute one of the most feared perioperative complications of thyroid surgery and parathyroid glands, in terms of impact in clinical and economic-social costs. Moreover, these events rank among the leading reasons for medicolegal litigation of surgeons because of its attendant reduction in quality of life. The average incidence of RLN paralysis, permanent and temporary, after thyroidectomy is high and stands between 2. Read More

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http://dx.doi.org/10.21037/gs.2019.10.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995897PMC
January 2020

Co-occurrence of multiple endocrine neoplasia type 4 and spinal neurofibromatosis: a case report.

Fam Cancer 2020 Apr;19(2):189-192

Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, A440 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Multiple Endocrine Neoplasia (MEN) type 4 is a rare genetic condition that results from variants of the CDKN1B gene and predisposes individuals to develop endocrine tumors. Spinal neurofibromatosis (SNF) is an uncommon subtype of neurofibromatosis type 1 (NF1) characterized by bilateral neurofibromas of all spinal roots. Here we report a case of the co-occurrence of these syndromes, which has not yet been described in the literature. Read More

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http://dx.doi.org/10.1007/s10689-019-00152-6DOI Listing

[Intraoperative measurement of parathyroid hormone in hyperparathyroidism].

Chirurg 2020 Jun;91(6):448-455

Klinik für Viszeral‑, Gefäß- und Endokrine Chirurgie, Universitätsklinikum Halle, Martin-Luther Universität Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle an der Saale, Deutschland.

Intraoperative parathyroid hormone (IOPTH) determination is based on the short half-life of parathyroid hormone (PTH) and the rapid analytical technology. The IOPTH provides functional information regarding correction of the overproductive state in hyperparathyroidism (HPT) and is superior to macroscopic evaluation of the parathyroid gland (PG) as well as any (intraoperative frozen section) form of histology (so-called biochemical frozen section). In this article the relevance and evaluation of IOPTH is defined for the most important forms of HPT, for primary HPT, renal secondary and tertiary HPT, multiple endocrine neoplasia type 1 (MEN1) and parathyroid carcinoma and clinical scenarios based on the currently available data. Read More

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http://dx.doi.org/10.1007/s00104-020-01123-9DOI Listing