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    1 OF 249

    Evaluating the effectiveness of prophylactic central neck dissection with total thyroidectomy for cN0 papillary thyroid carcinoma: An update meta-analysis.
    Eur J Surg Oncol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, PR China. Electronic address:
    Background: The effectiveness of prophylactic central neck dissection (pCND) following total thyroidectomy (TT) in patients with clinical node-negative (cN0) papillary thyroid carcinoma (PTC) is still controversial. The aim of the meta-analysis is to evaluate the outcome of pCND and provide quantitative evidence.

    Method: A detailed literature search of PubMed, EMBASE, ClinicalTrails. Read More

    Radioguided surgery in primary hyperparathyroidism: Results and correlation with intraoperative histopathologic diagnosis.
    Acta Otorrinolaringol Esp 2017 Aug 11. Epub 2017 Aug 11.
    Servicio de Endocrinología, Hospital San Pedro de Alcántara , Cáceres, España.
    Introduction And Objectives: Radioguided surgery is a minimally invasive surgical technique for the treatment of primary hyperparathyroidism. The goals of our study were to evaluate the rate of success and compare the results with intraoperative histological analysis.

    Methods: We retrospectively studied 84 patients with primary parathyroidism who had undergone radioguided surgery. Read More

    [Pay attention to the standardized application of new techniques in surgical treatment of thyroid disease].
    Zhonghua Wai Ke Za Zhi 2017 Aug;55(8):561-565
    Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
    The continuous development and application of new technology in thyroid surgery has promoted the rapid improvement of thyroid surgery. New technology in the field of thyroid surgery has developed rapidly. The application of neural monitoring technology has enabled the thyroid surgery to enter an accurate era. Read More

    In situ preservation of the inferior parathyroid gland during central neck dissection for papillary thyroid carcinoma.
    Br J Surg 2017 Aug 7. Epub 2017 Aug 7.
    Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Background: Postoperative hypocalcaemia due to dysfunction of the parathyroid glands is the most common complication after total thyroidectomy plus central neck dissection (CND). There is a lack of surgical techniques described to help preserve the inferior parathyroid gland in situ during CND. The objective of this study was to introduce the 'TBP layer' (layer of thymus-blood vessel-inferior parathyroid gland) concept for preserving the inferior parathyroid gland in situ during CND, and to evaluate its effectiveness. Read More

    Large intragenic deletion of CDC73 (exons 4-10) in a three-generation hyperparathyroidism-jaw tumor (HPT-JT) syndrome family.
    BMC Med Genet 2017 Aug 3;18(1):83. Epub 2017 Aug 3.
    Departments of Laboratory Medicine and Pathobiology, Medicine and Genetics, University of Toronto, Toronto, ON, Canada.
    Background: Inactivating mutations of CDC73 cause Hyperparathyroidism-Jaw Tumour syndrome (HPT-JT), Familial Isolated Hyperparathyroidism (FIHP) and sporadic parathyroid carcinoma. We conducted CDC73 mutation analysis in an HPT-JT family and confirm carrier status of the proband's daughter.

    Methods: The proband had primary hyperparathyroidism (parathyroid carcinoma) and uterine leiomyomata. Read More

    Bilateral pheochromocytoma with ganglioneuroma component associated with multiple neuroendocrine neoplasia type 2A: a case report.
    J Med Case Rep 2017 Aug 1;11(1):208. Epub 2017 Aug 1.
    Department of Pathology, Hassan II University Hospital, Fès, Morocco.
    Background: Composite pheochromocytoma/paragangliomas are very rare tumors composed of ordinary pheochromocytoma paragangliomas associated with neurogenic tumors. Several hereditary susceptibility disorders are known to be associated with pheochromocytoma/paragangliomas such as multiple endocrine neoplasia type 2 (2A or B). To the best of our knowledge, only four cases of composite pheochromocytoma/paragangliomas associated with multiple endocrine neoplasia type 2 have been reported. Read More

    Postoperative local-regional radiation therapy in the treatment of parathyroid carcinoma: The MD Anderson experience of 35 years.
    Pract Radiat Oncol 2017 Jul 21. Epub 2017 Jul 21.
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:
    Purpose: We aimed to investigate outcomes of locoregional radiation therapy (XRT) in parathyroid carcinoma (PC) patients at a single institution over 35 years.

    Methods And Materials: Retrospective review of PC patients who received postoperative locoregional XRT (1980-2015). Patients were grouped according to XRT after PC initial operation or after salvage surgery. Read More

    [Disseminated osteolytic lesions in a 28-year-old refugee].
    Internist (Berl) 2017 Jul 26. Epub 2017 Jul 26.
    Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg, Standort Gießen, 35392, Gießen, Deutschland.
    A 28-year-old Syrian refugee presented with right-sided knee pain and progressive deterioration of the general condition over the past months. Laboratory diagnostics revealed severe hypercalcemia due to primary hyperparathyroidism, and computed tomography (CT) scanning demonstrated disseminated osteolytic lesions throughout the skeleton. Histologically, these lesions were characterized by multinuclear giant cells (defining these lesions as so-called brown tumors). Read More

    Case report: rare skeletal manifestations in a child with primary hyperparathyroidism.
    BMC Endocr Disord 2017 Jul 21;17(1):45. Epub 2017 Jul 21.
    Orthopaedic Unit, National Hospital Sri Lanka, Colombo, Sri Lanka.
    Background: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. Read More

    Non-functioning parathyroid carcinoma: a case report.
    Surg Case Rep 2017 Dec 19;3(1):81. Epub 2017 Jul 19.
    Yokohama City University, Yokohama, Japan.
    Background: Non-functioning parathyroid carcinoma is a rare disease that is difficult to distinguish from other diseases based on the lack of hyperparathyroidism. This is a report of non-functioning parathyroid carcinoma diagnosed by reverse transcription polymerase chain reaction (RT-PCR) targeting parathyroid hormone (PTH) messenger RNA.

    Case Presentation: The patient is a 67-year-old male who visited our hospital for the chief complaint of hoarseness. Read More

    The safety of available treatments options for neuroendocrine tumors.
    Expert Opin Drug Saf 2017 Jul 20:1-13. Epub 2017 Jul 20.
    b Department of Clinical Medicine and Surgery , Federico II University , Naples , Italy.
    Introduction: Neuroendocrine neoplasms (NEN) represent a heterogeneous group of malignancies generally characterized by low proliferation and indolent course. However, about half of the newly diagnosed cases are metastatic and require long-term systemic therapies. Areas covered: This review revises the literature to summarize the current knowledge upon safety of all systemic treatment options available. Read More

    Hashimoto's thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer.
    Endocr Relat Cancer 2017 Sep 10;24(9):485-493. Epub 2017 Jul 10.
    Thyroid and Parathyroid Surgery UnitIstituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS 'Fondazione G. Pascale', Naples, Italy.
    Hashimoto's thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analysing all disease stages. Given that HT-related microenvironment involves solely the thyroid, we aimed to assess the relationship between HT, as detected through pathological assessment, and outcome in intrathyroidal PTC. This was a multicentre, retrospective, observational study including 301 PTC with no evidence of extrathyroidal disease. Read More

    Novel association of MEN1 gene mutations with parathyroid carcinoma.
    Oncol Lett 2017 Jul 12;14(1):23-30. Epub 2017 May 12.
    Department of Medical Genetics, IRCCS Casa Sollievo della Sofferenza Hospital, I-71013 San Giovanni Rotondo, Italy.
    Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases carrying an inactivating mutation of the MEN1 gene. The present study presents the case of a 48-year-old female who presented with multigland pHPT and multiple pancreatic lesions. Read More

    Transoral thyroidectomy and parathyroidectomy - A North American series of robotic and endoscopic transoral approaches to the central neck.
    Oral Oncol 2017 Aug 10;71:75-80. Epub 2017 Jun 10.
    Division of Head and Neck Endocrine Surgery, Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: Most thyroid surgery in North America is completed via a cervical incision, which leaves a permanent scar. Approaches without cutaneous incisions offer aesthetic advantages. This series represents the largest series of transoral vestibular approaches to the central neck in North America, and the first published reports of robotic transoral vestibular thyroidectomy for thyroid carcinoma. Read More

    Concurrent intrathyroidal thymus and parathyroid in a patient with papillary thyroid carcinoma: a challenging diagnosis.
    Endocrinol Diabetes Metab Case Rep 2017 23;2017. Epub 2017 Jun 23.
    Departments of Surgery.
    During embryogenesis, the thymus and inferior parathyroid glands develop from the third pharyngeal pouch and migrate to their definite position. During this process, several anatomic variations may arise, with the thyroid being one of the most common sites of ectopic implantation for both organs. Here, we report the case of a young female patient, who underwent total thyroidectomy for papillary carcinoma of the thyroid. Read More

    A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid.
    Int J Surg Case Rep 2017 17;37:83-86. Epub 2017 Jun 17.
    Surgical Oncologist, Department of Surgery, Texas Tech University School of Medicine, Amarillo, TX, USA. Electronic address:
    Introduction: Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH). To date no report of a follicular adenoma with OM and mature EBF in the absence of EMH has been reported in the English language.

    Presentation Of Case: 63-year-old woman with an incidental finding of thyroid nodule unable to be biopsied. Read More

    A role for TET2 in parathyroid carcinoma.
    Endocr Relat Cancer 2017 07;24(7):329-338
    Department of Surgical SciencesEndocrine Unit, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Primary hyperparathyroidism (pHPT) is rarely caused by parathyroid carcinoma (PC, <1-5% of pHPT cases). The TET proteins oxidize the epigenetic mark 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and inactivation by mutation or epigenetic deregulation of TET1 and TET2 play important roles in various cancers. Recently, we found that 5hmC was severely reduced in all of the analyzed PCs and with deranged expression of TET1 for the majority of PCs. Read More

    Lymph node metastasis characteristics of papillary thyroid carcinoma located in the isthmus: A single-center analysis.
    Medicine (Baltimore) 2017 Jun;96(24):e7143
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China.
    The frequency and pattern of lymph node metastasis and the extent of dissection for isthmic papillary thyroid carcinoma (PTC) remain unclear, and the aim of this present study was to evaluate these characteristics and to attempt to detect the best surgical protocol for isthmic PTCs. A total of 3185 consecutive patients with PTCs were reviewed. Of these patients, 47 with a single isthmic PTC were enrolled in our study, and matched 47 patients with a single PTC located in the unilateral lobe were randomly selected and added for comparison of their baseline tumor characteristics and lymph node metastasis characteristics. Read More

    Value of 99mTc-MIBI SPECT/CT parathyroid imaging and ultrasonography for concomitant thyroid carcinoma.
    Nucl Med Commun 2017 Aug;38(8):676-682
    Departments of aNuclear Medicine bEndocrine and Metabolic Diseases, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Purpose: We aimed to assess the frequency of carcinoma in cases with suspected parathyroid adenoma and test the value of Tc-methoxyisobutylisonitrile (Tc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) parathyroid imaging and neck ultrasonography in detecting concomitant thyroid carcinoma.

    Patients And Methods: We enrolled 741 patients with clinically suspected parathyroid adenoma who underwent Tc-MIBI planer scans and SPECT/CT of the skull base, neck, and thorax; patients also underwent ultrasonography within 1 month before SPECT/CT. Each case with suspected lesion was analyzed and correlated with pathology. Read More

    Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.
    Biomed Pharmacother 2017 Aug 9;92:843-848. Epub 2017 Jun 9.
    Department of Oncological Surgical and Gastroenterological Sciences (DiSCOG), University of Padova, Padova, Italy.
    Objective: Sporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. Read More

    Hypercalcemia due to Nasopharyngeal Carcinoma.
    JNMA J Nepal Med Assoc 2017 Jan-Mar;56(205):182-185
    Department of Pediatrics & Adolescent Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal.
    Hypercalcemia is a rare metabolic disorder associated with hyperparathyroidism, malignancy and various other causes. Although common in adult malignancies, hypercalcemia is rare in pediatrics and purports poor prognosis. Nasopharyngeal carcinoma is rare with no reported hypercalcemic presentation. Read More

    Benign and Malignant Thyroid Gland Diseases in the Patients with Primary Hyperparathyroidism.
    Int J Appl Basic Med Res 2017 Apr-Jun;7(2):117-120
    Department of Endocrinology and Metabolism, Medical Faculty, Trakya University, Edirne, Turkey.
    Introduction: This study aimed to evaluate concurrently detected thyroid pathologies in the patients who underwent surgery for primary hyperparathyroidism (PHPT).

    Materials And Methods: In this study, we retrospectively analyzed the files of the patients who underwent surgery for PHPT between 2012 and 2015. Pre- and post-operative laboratory examination results and preoperative radiological and nuclear medicine findings of the patients were retrospectively recorded. Read More

    Papillary carcinoma of the thyroid in patients with primary hyperparathyroidism: Is there a link?
    Med Hypotheses 2017 Jun 26;103:100-104. Epub 2017 Apr 26.
    Diabetes and Endocrinology, Thomas Addison Unit, St George's Healthcare NHS Trust, London, UK. Electronic address:
    Primary hyperparathyroidism (PHPT) is present in up to 0.1% of the general population. The incidence is higher in women and increases with age. Read More

    Hypercalcaemic encephalopathy due to metastatic parathyroid carcinoma.
    BMJ Case Rep 2017 May 31;2017. Epub 2017 May 31.
    Department of Endocrine Surgery, Madras Medical College, Chennai, Tamilnadu, India.
    A 49-year-old man presented in the emergency department with altered sensorium and renal failure and was placed on a ventilator. Evaluation with MRI of the brain showed enhancing lesion in the occipital lobe. Biochemical tests revealed elevated calcium and parathyroid hormone (PTH) levels. Read More

    Comparison of the prognostic values of selected inflammation based scores in patients with medullary thyroid carcinoma: A pilot study.
    J Surg Oncol 2017 Sep 29;116(3):281-287. Epub 2017 May 29.
    Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.
    Background: The significance of inflammation based scores including the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and plasma fibrinogen remains unclear in medullary thyroid carcinoma (MTC). We aimed to compare the prognostic value of these scores.

    Methods: Seventy-eight patients newly diagnosed as MTC with operation in our institution from May 2009 to September 2016 were retrospectively evaluated. Read More

    A study of FoxA1 expression in thyroid tumors.
    Hum Pathol 2017 Jul 22;65:217-224. Epub 2017 May 22.
    Department of Histopathology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK; Institute of Cancer Sciences, The University of Manchester, Manchester M20 4BX, UK. Electronic address:
    FoxA1 regulates a variety of tissues during embryogenesis and early life. In thyroid, FoxA1 expression has recently been shown in C cells and medullary thyroid carcinomas but not in follicular cells. FoxA1 has also been proposed as a potential oncogene in anaplastic thyroid carcinomas. Read More

    Extensive Visceral Calcification Demonstrated on (99m)Tc-MDP Bone Scan in Patient with Carcinoma Penis and Hypercalcemia of Malignancy.
    Indian J Nucl Med 2017 Apr-Jun;32(2):150-152
    Department of Radio-Diagnosis, Infocus Diagnostics, Ahmedabad, Gujarat, India.
    Hypercalcemia is a common life-threatening complication associated with several malignancies. Parathyroid-related peptide has been shown to cause hypercalcemia in several solid tumors but rarely in penile cancer. We report a case of penile cancer with hypercalcemia causing metastatic visceral calcification in lungs, liver, and stomach detected on bone scan without significant abnormalities on CT scan. Read More

    Effectiveness of Intraoperative Parathyroid Monitoring (ioPTH) in predicting a multiglandular or malignant parathyroid disease.
    Int J Surg 2017 May;41 Suppl 1:S26-S33
    Division of General Surgery, Department of Medical, Surgical and Health Sciences, Cattinara Teaching Hospital, Strada di Fiume, 34149, Trieste, Italy. Electronic address:
    Aim: The main goal of our study was to confirm the usefulness of intra-operative parathyroid hormone (PTH) monitoring (ioPTH) when using minimally invasive techniques for treatment of sporadic Primary hyperparathyroidism (pHTP). Furthermore, we aimed to evaluate if ioPTH monitoring may help to predict the etiology of primary hyperparathyroidism, especially in malignant or multiglandular parathyroid disease.

    Methods: A retrospective review of 125 consecutive patients with pHPT who underwent parathyroidectomy between 2001 and 2016 at the Department of General Surgery was performed. Read More

    Giant parathyroid adenoma: differential aspects compared to parathyroid carcinoma.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 May 6.
    Endocrinology and Nutrition DepartmentHospital Puerta de Hierro, Majadahonda, MadridSpain.
    The 85% of cases of primary hyperparathyroidism (PHPT) are due to parathyroid adenomas (PA) and less than 1% to parathyroid carcinomas (PC). The PA usually measure <2 cm, weigh <1 g and generate a mild PHPT, whereas the PC usually exceeds these dimensions and are associated with a severe PHPT. However, giant PA (GPA), which is defined as those larger than 3 g, has been documented. Read More

    Efficacy of Superselective Neck Dissection in Detecting Metastasis in Patients with cN0 Papillary Thyroid Carcinoma at High Risk of Lateral Neck Metastasis.
    Med Sci Monit 2017 May 4;23:2118-2126. Epub 2017 May 4.
    Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Science (CAMS), Peking Union Medical College (PUMC), Beijing, China (mainland).
    Background Material and Methods Results Conclusions. Read More

    Evaluation of the radiation dose exposure and associated cancer risks in patients having preoperative parathyroid localization.
    Ann R Coll Surg Engl 2017 May;99(5):363-368
    Department of General Surgery, Ipswich Hospital NHS Trust , Ipswich, Suffolk , UK.
    OBJECTIVE The study aimed to evaluate the total effective and organ absorbed radiation doses associated with three- and four-phase parathyroid computed tomography (CT) and sestamibi scans used for the preoperative localisation of parathyroid adenomas in a cohort of patients with primary hyperparathyroidism at a single institution. We aimed to assess the risk of cancer incidence for the organs demonstrating the highest absorbed doses for the different imaging techniques, and more specifically determine the risk for our cohort of patients. METHODS Fifty patients with primary hyperparathyroidism had both multiphase CT and sestamibi scans. Read More

    Next-generation sequencing for endocrine cancers: Recent advances and challenges.
    Tumour Biol 2017 May;39(5):1010428317698376
    1 Department of Biosciences, Mangalore University, Mangalore, India.
    Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Read More

    Diagnosis and treatment challenges of parathyroid carcinoma in a 27-year-old woman with multiple lung metastases.
    Endocrinol Diabetes Metab Case Rep 2017 13;2017. Epub 2017 Mar 13.
    Endocrinology Research CentreMoscowRussia.
    Summary: Parathyroid carcinoma is an extremely rare disorder with little treatment options. It could be misdiagnosed in medical centers with little experience in management of such cases. Our clinical case shows that the initial misdiagnosis of a parathyroid carcinoma in a young woman has led to the development of multiple lung metastases, thus making its treatment hardly possible. Read More

    Surgical approaches in hereditary endocrine tumors.
    Updates Surg 2017 Jun 28;69(2):181-191. Epub 2017 Apr 28.
    Minimally Invasive Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
    Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. Read More

    Persistent and recurrent hyperparathyroidism.
    Updates Surg 2017 Jun 22;69(2):161-169. Epub 2017 Apr 22.
    Department of Endocrine Surgery, La Conception Hospital, Assistance Publique Hopitaux de Marseille, 147 BD Baille, 13005, Marseille, France.
    Despite remarkable progress in imaging modalities and surgical management, persistence or recurrence of primary hyperparathyroidism (PHPT) still occurs in 2.5-5% of cases of PHPT. The aim of this review is to expose the management of persistent and recurrent hyperparathyroidism. Read More

    Prognostic Scoring System to Risk Stratify Parathyroid Carcinoma.
    J Am Coll Surg 2017 Mar 15. Epub 2017 Mar 15.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Background: Parathyroid carcinoma is a rare endocrine malignancy that lacks an established system for risk categorization. This study evaluated a prognostic scoring system for recurrence-free survival (RFS) of patients with parathyroid carcinoma.

    Study Design: Patients diagnosed and confirmed to have parathyroid carcinoma and who were treated between 1980 and 2016 at The University of Texas MD Anderson Cancer Center were studied retrospectively. Read More

    The many guises of primary hyperparathyroidism: An unchanged scenario.
    J Pak Med Assoc 2017 Apr;67(4):580-585
    Medical Unit-II, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
    Objective: To study the causes, characteristics and outcome of treatment of patients with primary hyperparathyroidism.

    Methods: This retrospective cohort analysis was conducted at the Jinnah Postgraduate Medical Centre, Karachi, and comprised data of patients with primary hyperparathyroidism between 2004 and 2014. . Read More

    Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells.
    Am J Physiol Gastrointest Liver Physiol 2017 Jun 13;312(6):G649-G657. Epub 2017 Apr 13.
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan
    Parietal cells play a fundamental role in stomach maintenance, not only by creating a pathogen-free environment through the production of gastric acid, but also by secreting growth factors important for homeostasis of the gastric epithelium. The gastrointestinal hormone gastrin is known to be a central regulator of both parietal cell function and gastric epithelial cell proliferation and differentiation. Our previous gene expression profiling studies of mouse stomach identified parathyroid hormone-like hormone (PTHLH) as a potential gastrin-regulated gastric growth factor. Read More

    Molecular targeted therapies in adrenal, pituitary and parathyroid malignancies.
    Endocr Relat Cancer 2017 Jun 11;24(6):R239-R259. Epub 2017 Apr 11.
    Department of EndocrinologyOxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.
    Tumourigenesis is a relatively common event in endocrine tissues. Currently, specific guidelines have been developed for common malignant endocrine tumours, which also incorporate advances in molecular targeted therapies (MTT), as in thyroid cancer and in gastrointestinal neuroendocrine malignancies. However, there is little information regarding the role and efficacy of MTT in the relatively rare malignant endocrine tumours mainly involving the adrenal medulla, adrenal cortex, pituitary, and parathyroid glands. Read More

    Epigenetic processes in sporadic parathyroid neoplasms.
    Mol Cell Endocrinol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States. Electronic address:
    Parathyroid tumors (PTs) are highly variable in their genetic background. Increasing evidence demonstrates that endocrine diseases can be caused by epigenetic alterations. The present review is focused on epigenetic aberrations related to PTs. Read More

    Principles of ear nose and throat surgery for pregnant women.
    Br J Hosp Med (Lond) 2017 Apr;78(4):206-212
    Consultant, Department of Ear Nose and Throat Surgery, Heartlands Hospital, Birmingham.
    Management of the pregnant surgical patient is challenging. The surgical procedure is usually postponed until the postpartum period, although this may not be possible in emergency situations. This article highlights the optimal management of the pregnant woman requiring ear nose and throat surgery. Read More

    18F-Fluorocholine, 18F-FDG, and 18F-Fluoroethyl Tyrosine PET/CT in Parathyroid Cancer.
    Clin Nucl Med 2017 Jun;42(6):448-450
    From the *Clinical Institute of Nuclear Medicine and Endocrinology, and †Central Radiology Institute, Kepler University Hospital, Med. Campus III, Linz, Austria; ‡Medical Faculty of the University of Erlangen, Germany; and §Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
    We report on a 71-year-old woman presenting with biochemical features indicating recurrent disease in long-term follow-up of left-sided parathyroid carcinoma. She had undergone several surgical procedures including total thyroidectomy, partial resection of the esophageal wall, and curative neck radiation 12 years previously. PET/CT using F-fluorocholine revealed high uptake in local relapse in the lower neck, comparable to F-FDG, whereas only faint uptake was observed with F-fluoroethyl tyrosine. Read More

    Circulating tumor cells and miRNAs as prognostic markers in neuroendocrine neoplasms.
    Endocr Relat Cancer 2017 Jun 7;24(6):R223-R237. Epub 2017 Apr 7.
    IOS & COLEMAN SrlNaples, Italy.
    The prognosis of neuroendocrine neoplasms (NENs) is widely variable and has been shown to associate with several tissue- and blood-based biomarkers in different settings. The identification of prognostic factors predicting NEN outcome is of paramount importance to select the best clinical management for these patients. Prognostic markers have been intensively investigated, also taking advantage of the most modern techniques, in the perspective of personalized medicine and appropriate resource utilization. Read More

    Effects of sample storage and diluents in the reliability of thyroglobulin measurement in the washout of fine needle aspirates.
    Endocrine 2017 Jun 6;56(3):504-508. Epub 2017 Apr 6.
    Division of Endocrinology, Hospital "J.M. Ramos Mejía", Gral. Urquiza 609, Buenos Aires, 1221, Argentina.
    Objective: To evaluate two variables affecting Thyroglobulin stability in the washout of fine needle aspiration biopsies of thyroid nodules and metastatic lymph nodes.

    Materials And Methods: Thyroglobulin stability after storage at -20 °C up to 14 days was studied in washout performed with normal saline solution and further dilutions with normal saline solution from five metastatic thyroid nodes and six benign thyroid nodules. We also studied thyroglobulin stability in diluents compared with normal saline solution: 4% bovine serum albumin in normal saline solution and diluents free from thyroglobulin or Calcitonin or parathyroid hormone in paired and simultaneous thyroglobulin measurements of washout dilutions from 5/6 benign thyroid nodules and 2/5 metastatic lymph nodes. Read More

    RSK activation via ERK modulates human colon cancer cells response to PTHrP.
    J Mol Endocrinol 2017 Jul 6;59(1):13-27. Epub 2017 Apr 6.
    Departamento de BiologíaBioquímica y Farmacia, INBIOSUR, Universidad Nacional del Sur (UNS) - CONICET, Bahía Blanca, Argentina
    Parathyroid hormone-related peptide (PTHrP) is associated with several human cancers such as colon carcinoma. This disease is a complex multistep process that involves enhanced cell cycle progression and migration. Recently we obtained evidence that in the human colorectal adenocarcinoma Caco2 cells, exogenous PTHrP increases the proliferation and positively modulates cell cycle progression via ERK1/2, p38 MAPK and PI3K. Read More

    Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism.
    Int J Surg Pathol 2017 Aug 6;25(5):384-388. Epub 2017 Apr 6.
    1 Mount Sinai Medical Center, Miami Beach, FL, USA.
    Water clear cell adenoma of the parathyroid gland is a rare neoplasm composed of large clear cells with foamy cytoplasm and mild nuclear pleomorphism, compressing the residual nonneoplastic parathyroid tissue. The differential diagnosis includes a variety of neoplasms with clear cell features. In this article, we provide an overview of the entity with a historical perspective, in order to help pathologists in distinguishing it from other neoplasms in their daily practice. Read More

    Staged Surgery for Advanced Thyroid Cancers: Safety and Oncologic Outcomes of Neural Monitored Surgery.
    Otolaryngol Head Neck Surg 2017 May 4;156(5):816-821. Epub 2017 Apr 4.
    1 Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary & Harvard Medical School, Boston, Massachusetts, USA.
    Objective Thyroidectomy with extensive multicompartment bilateral neck dissections for advanced-stage thyroid cancer may lead to increased risk of complications, including bilateral recurrent laryngeal nerve (RLN) paralysis and hypoparathyroidism. A planned staged approach derived from a detailed preoperative radiographic map is associated with a low complication profile. This study evaluates oncologic results and safety of neural monitored, staged thyroid cancer surgery for management of advanced thyroid cancer. Read More

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