13,647 results match your criteria Parathyroid Carcinoma


Breast cancer in multiple endocrine neoplasia type 1 (MEN1).

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Endocrinology, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.

Summary: A 38-year-old female was identified as carrying a heterozygous pathogenic MEN1 variant (c.1304delG) through predictive genetic testing, following a diagnosis of familial hyperparathyroidism. Routine screening for parathyroid and pituitary disease was negative. Read More

View Article and Full-Text PDF

Duration of Parathyroid Function Recovery in Patients With Protracted Hypoparathyroidism After Total Thyroidectomy for Papillary Thyroid Carcinoma.

Front Endocrinol (Lausanne) 2021 19;12:665190. Epub 2021 Apr 19.

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China.

Purpose: The aim of the present study is to investigate the time to recovery of parathyroid function in patients with protracted hypoparathyroidism at 1 month after total thyroidectomy of papillary thyroid carcinoma.

Materials And Methods: Adult patients who underwent total thyroidectomy for papillary thyroid cancer were included. Cases of long-term hypoparathyroidism were studied for recovery of parathyroid function during the follow-up. Read More

View Article and Full-Text PDF

Squamous Cell Carcinoma of the Lung in McCune-Albright Syndrome.

Cureus 2021 Mar 28;13(3):e14159. Epub 2021 Mar 28.

Internal Medicine, Detroit Medical Center (DMC) Harper Hospital, Detroit, USA.

McCune Albright Syndrome (MAS) is caused by a mutation in the GNAS gene that results in multiple endocrinopathies such as Cushing syndrome, acromegaly, hyperthyroidism, and precocious puberty. Despite the presence of pleiotropy coupled with a GNAS gene mutation, malignancy is a rare occurrence in MAS. There is minimal literature showcasing squamous cell carcinoma (SCC) of the lung in patients with MAS. Read More

View Article and Full-Text PDF

Limited Clinical and Diagnostic Utility of Circulating Tumor DNA Detection in Patients with Early-Stage Well-Differentiated Thyroid Cancer: Comparison with Benign Thyroid Nodules and Healthy Individuals.

Healthcare (Basel) 2021 Apr 1;9(4). Epub 2021 Apr 1.

Hallym University Medical Center, Hallym Institute of Translational Genomics and Bioinformatics, Anyang 14068, Gyeonggi-do, Korea.

Limited data are available on the diagnostic utility of circulating tumor DNA (ctDNA) in early-stage thyroid cancers for , , , and promoter mutations, which are known detectable markers for thyroid cancers. Here, we analyzed the above driver mutations in ctDNA and matched neoplastic tissues from patients with early-stage thyroid cancers in order to investigate diagnostic utility of circulating markers in distinguishing from other mimicking thyroid lesions and healthy individuals. In total, 73 matched neoplastic tissue and plasma samples [thyroid cancers (n = 62), benign thyroid disorders (n = 8), and parathyroid lesions (n = 3)] and 54 plasma samples from healthy individuals (as controls) were analyzed for , , , and promoter mutations using peptide nucleic acid clamp real-time PCR. Read More

View Article and Full-Text PDF

Nonfunctional parathyroid cancer a case report.

Rozhl Chir 2021 ;100(3):133-137

Introduction: Parathyroid cancer is a rare endocrine malignancy. These tumors are typically functional, causing severe hypercalcemia due to primary hyperparathyroidism. Nonfunctional parathyroid cancer with normal serum calcium and parathyroid hormone levels is extremely rare. Read More

View Article and Full-Text PDF

Morbidity and mortality of parathyroid surgery - a retrospective analysis.

Rozhl Chir 2021 ;100(3):126-132

Introduction: The incidence of parathyroid - glandula parathyreoideae (PTG) diseases has been increasing worldwide. Unlike benign tumours, the incidence of malignant PTG tumours is rather a rare diagnosis. The morbidity of parathyroid surgery is associated with surgical removal of one or more pathologically altered parathyroid glands, particularly parathyroid adenoma associated with primary hyperparathyroidism (HPPT), but also hyperplasia associated with secondary or tertiary HPPT, and last but not least, HPPT due to parathyroid cancer. Read More

View Article and Full-Text PDF

Morbidity and mortality associated with thyroid surgery - retrospective analysis 19912010.

Rozhl Chir 2021 ;100(3):118-125

Introduction: The incidence of thyroid disorders has been rising worldwide. Unlike the incidence, mortality associated with malignant thyroid cancer shows only a modest increase. Between 1979 and 2009, mortality in Czech women increased from 1. Read More

View Article and Full-Text PDF

Multimodality Imaging Review of Multiple Endocrine Neoplasia.

AJR Am J Roentgenol 2021 Apr 28:1-12. Epub 2021 Apr 28.

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT.

The purpose of this article is to review the clinical manifestations, endocrine tumors types, and multimodality diagnostic tools available to physicians involved in the management of patients with multiple endocrine neoplasia (MEN) syndrome, in addition to discussing relevant imaging findings and appropriate imaging follow-up. Thorough knowledge of the spectrum of tumors associated with gene mutations aids in the screening, diagnostic workup, and posttreatment monitoring of patients with MEN-related gene mutations. Read More

View Article and Full-Text PDF

[The Therapy of Malignant Thyroid Disease from ENT-Perspective].

Laryngorhinootologie 2021 Apr 27. Epub 2021 Apr 27.

Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany.

Introduction:  Malignant tumours of the thyroid gland show a rising incidence. As in the ENT-department Bad Hersfeld the management of thyroid disorders has been in focus for a longer period, we want to share our experiences in this field.

Material And Methods:  The investigation started in the year of 2014 till July 2020. Read More

View Article and Full-Text PDF

Case Report: A New Entity: Multiple Differentiated Variant of Papillary Thyroid Carcinoma With Advanced Clinical Behavior.

Front Endocrinol (Lausanne) 2021 7;12:654638. Epub 2021 Apr 7.

Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.

There are many histological morphological types of papillary thyroid carcinoma (PTC), but the most frequently seen types are conventional. A single PTC commonly has a conventional and/or a variant morphological pattern. PTC with multiple (more than two) well-differentiated morphological patterns are extremely rare. Read More

View Article and Full-Text PDF

Management of primary and renal hyperparathyroidism: guidelines from the German Association of Endocrine Surgeons (CAEK).

Langenbecks Arch Surg 2021 May 21;406(3):571-585. Epub 2021 Apr 21.

Ratajczak & Partner, Freiburg, Germany.

Background And Aims: The purpose of this review is to provide updated recommendations for the surgical management of primary (pHPT) and renal (rHPT) hyperparathyroidism, formulating a new guideline of the German Association of Endocrine Surgeons (CAEK).

Methods: Evidence-based recommendations for the diagnosis and therapy of pHPT and rHPT were assessed by a multidisciplinary panel using PubMed for a comprehensive literature search together with a structured consensus dialogue (S2k guideline of the Association of the German Scientific Medical Societies, AWMF).

Results: During the last 20 years, a variety of new preoperative localization procedures, such as sestamibi-SPECT, 4D-CT, and various PET/CT procedures, were established for pHPT. Read More

View Article and Full-Text PDF

In silico screening using bulk and single-cell RNA-seq data identifies RIMS2 as a prognostic marker in basal-like breast cancer: A retrospective study.

Medicine (Baltimore) 2021 Apr;100(16):e25414

Department of Thyroid Surgery.

Abstract: Single-cell RNA-seq has become a powerful tool to understand tumor cell heterogenicity. This study tried to screen prognosis-related genes in basal-like breast tumors and evaluate their correlations with cellular states at the single-cell level.Bulk RNA-seq data of basal-like tumor cases from The Cancer Genome Atlas-Breast Cancer (TCGA-BRCA) and single-cell RNA-seq from GSE75688 were retrospectively reviewed. Read More

View Article and Full-Text PDF

A Collision Intrathyroidal Tumor Causing Primary Hyperparathyroidism: Evidence From an 18F-Choline PET/CT Study.

Clin Nucl Med 2021 Apr 15. Epub 2021 Apr 15.

From the Departments of Internal Medicine Pathology, Galliera Hospital Departments of Pathology Endocrine Surgery, San Martino Hospital Department of Nuclear Medicine, Galliera Hospital, Genoa, Italy.

Abstract: A 67-year-old man was diagnosed with primary hyperparathyroidism and normofunctioning left nodular goiter. Fine-needle aspiration cytology showed thyroid (Thy) 4 (suspicious of malignancy). After first-line imaging proved negative, integrated 18F-choline PET/4D contrast-enhanced CT revealed uptake by the thyroid nodule and by 3 nodules of the left central compartment. Read More

View Article and Full-Text PDF

Humoral hypercalcaemia in an infant: a diagnostic dilemma.

J Clin Pathol 2021 Apr 15. Epub 2021 Apr 15.

Department of Chemical Pathology, University of Pretoria Faculty of Health Sciences, Pretoria, Gauteng, South Africa

View Article and Full-Text PDF

Debulking surgery for functional pleural dissemination of parathyroid carcinoma-case report.

J Cardiothorac Surg 2021 Apr 15;16(1):86. Epub 2021 Apr 15.

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2-L5, Yamadaoka, Suita, 565-0871, Osaka, Japan.

Background: A rare cause of primary hyperparathyroidism (PHPT) is a parathyroid carcinoma. Hypercalcemia with an elevated parathyroid hormone (PTH) level seen in recurrent and metastasis disease cases is often refractory to medical therapy, thus surgical resection is recommended when possible. We performed debulking surgery for pleural dissemination of parathyroid cancer for improvement of symptoms in a patient with hypercalcemia. Read More

View Article and Full-Text PDF

Intrathyroidal parathyroid carcinoma: a case report and literature review.

Radiat Oncol J 2021 Mar 24. Epub 2021 Mar 24.

Department of Radiation Oncology, National Institute of Oncology, Rabat, Morocco.

Parathyroid carcinoma is an uncommon endocrine malignancy comprising 0.5%-2% of patients with primary hyperparathyroidism. The probability of an intrathyroidal location is low (0. Read More

View Article and Full-Text PDF

Comprehensive analysis of the lncRNA-miRNA-mRNA regulatory network for bladder cancer.

Transl Androl Urol 2021 Mar;10(3):1286-1301

Department of Urology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.

Background: Long non-coding RNAs (lncRNAs) are essential regulators for various human cancers. However, these lncRNAs need to be further classified for cancer. In the present study, we identified novel competing endogenous RNA (ceRNA) network for bladder cancer (BC) and explored the gene functions of the ceRNA regulatory network. Read More

View Article and Full-Text PDF

Double ipsilateral parathyroid adenomas, with one supernumerary and ectopic at the same time: a case report.

J Med Case Rep 2021 Apr 13;15(1):198. Epub 2021 Apr 13.

1st Surgical Department, 424 General Military Hospital, Ring Road, 56429, EfkarpiaThessaloniki, Greece.

Background: Double adenomas (DA) represents a distinct clinical entity of primary hyperparathyroidism (PHPT). DA may follow various embryologic distribution patterns and could be supernumerary and/or ectopic.

Case Presentation: We describe the first case of PHPT which comes as a result of double ipsilateral adenoma, of which one was both ectopic and supernumerary. Read More

View Article and Full-Text PDF

Relationship between the extent of central node dissection and parathyroid function preservation in thyroid cancer surgery.

Gland Surg 2021 Mar;10(3):1093-1103

Department of Head and Neck Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: The risk and effect of hypocalcemia following surgery of different magnitudes remains unclear. Thus, we assessed whether different extents of central lymph node dissection (CLND) and status of preserved parathyroid glands can influence parathyroid function in differentiated thyroid carcinoma (DTC) patients with initial surgical resection.

Methods: Participants were categorized into 6 groups based on the extent of the surgical procedures, number of parathyroid glands preserved , and parathyroid autotransplantation. Read More

View Article and Full-Text PDF

New therapies for patients with multiple endocrine neoplasia type 1.

Ann Endocrinol (Paris) 2021 Apr 8;82(2):112-120. Epub 2021 Apr 8.

Institut CardioMet, Toulouse, France; Service d'endocrinologie, hôpital Larrey, 24, chemin de Pouvourville, 31029 Toulouse cedex 9, France. Electronic address:

In 1953, for the first time, Paul Wermer described a family presenting endocrine gland neoplasms over several generations. The transmission was autosomal dominant and the penetrance was high. Forty years later in 1997, the multiple endocrine neoplasia type 1 (MEN1) gene was sequenced, thus enabling diagnosis and early optimal treatment. Read More

View Article and Full-Text PDF

Giant parathyroid adenoma and challenges with preoperative differentiation from malignancy.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Department of Oral and Maxillofacial Surgery, University Hospitals Sussex NHS Foundation Trust, St Richards Hospital, Chichester and Worthing Hospital, Worthing, UK

Giant parathyroid adenomas are rare and underreported benign tumours of parathyroid gland. Preoperative differentiation between giant parathyroid adenoma (GPA) and parathyroid carcinoma can be challenging, as they both may present as a large parathyroid tumour with hyperparathyroidism. Very few GPAs had been described in the literature, with only 60 cases including our present case. Read More

View Article and Full-Text PDF

Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management.

Front Endocrinol (Lausanne) 2021 23;12:643328. Epub 2021 Mar 23.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.

Parathyroid carcinoma (PC) is an orphan malignancy accounting for only ~1% of all cases with primary hyperparathyroidism. The localization of recurrent PC is of critical importance and can be exceedingly difficult to diagnose and sometimes futile when common sites of recurrence in the neck and chest cannot be confirmed. Here, we present the diagnostic workup, molecular analysis and multimodal therapy of a 46-year old woman with the extraordinary manifestation of abdominal lymph node metastases 12 years after primary diagnosis of PC. Read More

View Article and Full-Text PDF

Protective strategy of parathyroid glands during thyroid lobectomy: A retrospective cohort and case-control study.

Medicine (Baltimore) 2021 Apr;100(14):e21323

Center of Thyroid & Parathyroid Surgery.

Abstract: Parathyroid protection during thyroid lobectomy was not illustrated previously. Aim of this study was to find out the influence of parathyroid glands in situ preservation and autotransplantation on postoperative parathyroid function in thyroid lobectomy.Consecutive patients who underwent primary thyroid lobectomy with unilateral central neck dissection for papillary thyroid carcinoma in our center were included retrospectively. Read More

View Article and Full-Text PDF

Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature.

BMC Endocr Disord 2021 Apr 7;21(1):60. Epub 2021 Apr 7.

General Surgery Unit, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia, 80138, Naples, Italy.

Background: Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. Read More

View Article and Full-Text PDF

A Pediatric Parathyroid Carcinoma: An Unusual Clinical Presentation and Mini-review.

Int J Endocrinol Metab 2021 Jan 25;19(1):e110234. Epub 2021 Jan 25.

Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Introduction: Primary hyperparathyroidism (PHPT) is a rare condition in the pediatric population. Parathyroid carcinoma (PC) is a very uncommon cause of PHPT, accounting for < 1% of pediatric PHPT cases. It is challenging to distinguish between parathyroid adenoma (PA), the most common cause of PHPT, and PC. Read More

View Article and Full-Text PDF
January 2021

Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma.

Front Vet Sci 2021 16;8:637614. Epub 2021 Mar 16.

School of Science, RMIT University, Bundoora, VIC, Australia.

Osteosarcoma (OS) is the most common primary bone tumor and originates from bone forming mesenchymal cells and primarily affects children and adolescents. The 5-year survival rate for OS is 60 to 65%, with little improvement in prognosis during the last four decades. Studies have demonstrated the evolving roles of parathyroid hormone-related protein (PTHrP) and its receptor (PTHR1) in bone formation, bone remodeling, regulation of calcium transport from blood to milk, regulation of maternal calcium transport to the fetus and reabsorption of calcium in kidneys. Read More

View Article and Full-Text PDF

Gastroenteropancreatic neuroendocrine neoplasms: A clinical snapshot.

World J Gastrointest Surg 2021 Mar;13(3):231-255

Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, PR2 9HT, Preston, The University of Manchester, Oxford Road M13 9PL, Manchester Metropolitan University, All Saints Building M15 6BH, Manchester, United Kingdom.

Our understanding about the epidemiological aspects, pathogenesis, molecular diagnosis, and targeted therapies of neuroendocrine neoplasms (NENs) have drastically advanced in the past decade. Gastroenteropancreatic (GEP) NENs originate from the enteroendocrine cells of the embryonic gut which share common endocrine and neural differentiation factors. Most NENs are well-differentiated, and slow growing. Read More

View Article and Full-Text PDF

Calcitriol-mediated hypercalcemia as an immune-related adverse event in a patient receiving nivolumab and ipilimumab for metastatic renal cell carcinoma, case report.

BMC Urol 2021 Apr 1;21(1):51. Epub 2021 Apr 1.

Medical Oncology, Ohio State University James Cancer Hospital, Suite 1335 Lincoln Tower, 1800 Cannon Drive, Columbus, OH, 43210, USA.

Background: Severe hypercalcemia is often associated with uncontrolled malignancy through several mechanisms. However, calcitriol-mediated hypercalcemia is a rare etiology for advanced solid tumors.

Case Presentation: We report a case of calcitriol-mediated hypercalcemia secondary to immune checkpoint inhibition in a responder with metastatic clear cell renal cell carcinoma (ccRCC). Read More

View Article and Full-Text PDF

Hyperparathyroidism-Jaw Tumor Syndrome.

Case Rep Oncol 2021 Jan-Apr;14(1):29-33. Epub 2021 Feb 18.

Division of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Primary hyperparathyroidism is a relatively common endocrine disorder, affecting 7 out of 1,000 adults. The median age at onset is the 6th decade of life. Our objective was to present a young patient with primary hyperparathyroidism who has a positive mutation. Read More

View Article and Full-Text PDF
February 2021

LINC01816 promotes the migration, invasion and epithelial‑mesenchymal transition of thyroid carcinoma cells by sponging miR‑34c‑5p and regulating CRABP2 expression levels.

Oncol Rep 2021 May 31;45(5). Epub 2021 Mar 31.

Department of Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China.

Thyroid carcinoma (THCA) is a common type of endocrine system cancer and its current clinical treatment method is surgical resection. Long non‑coding RNAs (lncRNAs) have been revealed to serve important roles in a variety of complex human diseases. Therefore, determining the association between lncRNAs and diseases may provide novel insight into disease‑related lncRNAs, with the aim of improving disease treatments and diagnoses. Read More

View Article and Full-Text PDF