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    1 OF 246

    Synchronous papillary thyroid carcinoma and breast ductal carcinoma: A rare case report and literature review.
    Medicine (Baltimore) 2017 Feb;96(7):e6114
    aDepartment of Pathology, West China Hospital of Sichuan University bThyroid and Parathyroid Surgery Group, West China Hospital of Sichuan University, Chengdu 610041, China.
    Background: The incidences of both thyroid cancer and breast cancer have been rising in recent years; however, it is very rare to find a single person with both of these cancers. Only a few cases of synchronous thyroid and breast cancer have been published, and even fewer cases have been reported in older patients (>60 years).

    Case Summary: The current study presents a case of synchronous papillary thyroid carcinoma and breast ductal carcinoma in an elderly patient. Read More

    Preoperative adjuvant transarterial chemoembolization cannot improve the long term outcome of radical therapies for hepatocellular carcinoma.
    Sci Rep 2017 Feb 3;7:41624. Epub 2017 Feb 3.
    Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China.
    Combinations of transarterial chemoembolization (TACE) and radical therapies (pretransplantation, resection and radiofrequency ablation) for hepatocellular carcinoma (HCC) have been reported as controversial issues in recent years. A consecutive sample of 1560 patients with Barcelona Clinic Liver Cancer (BCLC) stage A/B HCC who underwent solitary Radiofrequency ablation (RFA), resection or liver transplantation (LT) or adjuvant pre-operative TACE were included. The 1-, 3- and 5-year overall survival rates and tumor-free survival rates were comparable between the solitary radical therapy group and TACE combined group in the whole group and in each of the subgroups (RFA, resection and LT) (P > 0. Read More

    Parathyroid Adenoma Mimicking a Malignant Lymph Node on 18F-Choline PET-CT.
    Clin Nucl Med 2017 Jan 27. Epub 2017 Jan 27.
    From the *Department of Nuclear Medicine, University Hospital Ghent, Ghent; †Department of Oncology, AZ Sint-Lucas, Bruges; ‡Department of Uro-oncology, University Hospital Ghent, Ghent; and §Department of Nuclear Medicine, AZ Sint-Lucas, Bruges, Belgium.
    Prostate carcinoma is the most common cancer in men. After local therapy, disease recurs in many patients. A choline PET/CT is indicated in case of biochemical relapse of prostate carcinoma to determine the site of recurrence (local and/or distant) and to help select the next line of therapy. Read More

    Primary Hyperparathyroidism: Effects on Bone Health.
    Endocrinol Metab Clin North Am 2017 Mar 14;46(1):87-104. Epub 2016 Dec 14.
    Section of Endocrine Surgery, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, 72-250 CHS, Los Angeles, CA 90095, USA. Electronic address:
    Primary hyperparathyroidism (PHPT) is the most common cause of chronic hypercalcemia. With the advent of routine calcium screening, the classic presentation of renal and osseous symptoms has been largely replaced with mild, asymptomatic disease. In hypercalcemia caused by PHPT, serum parathyroid hormone levels are either high, or inappropriately normal. Read More

    Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation.
    Sci Rep 2017 Jan 25;7:41131. Epub 2017 Jan 25.
    National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
    Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role of RUNX2/PTHLH axis, which is stimulated HNSCC cell growth. Read More

    Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families.
    Medicine (Baltimore) 2017 Jan;96(3):e5967
    aDepartment of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, PR China bDepartment of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA.
    Backgroud: Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal dominant mutations in RET (rearranged during transfection) gene that predisposes the carrier to extremely high risk of medullary thyroid cancer (MTC) and other MEN2A-associated tumors such as parathyroid cancer and/or pheochromocytoma. Little is reported about MEN2A syndrome in the Chinese population.

    Methods: All members of the 3 families along with specific probands of MEN2A were analyzed for their clinical, laboratory, and genetic characteristics. Read More

    Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1.
    Respir Med Case Rep 2017 18;20:77-81. Epub 2016 Dec 18.
    Department of Internal Medicine, Ojiya General Hospital, Niigata, Japan; Center of Diabetes, Endocrinology and Metabolism, Joetsu General Hospital, Niigata, Japan.
    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by heterozygous germline mutations in the tumor suppressor gene MEN1, which encodes a nuclear protein, menin. MEN1 is characterized by the combined occurrence of tumors involving the pituitary gland, pancreatic islets, and parathyroid glands. Additionally, patients with MEN1 often exhibit adrenal tumors. Read More

    Trans Am Clin Climatol Assoc 2016 ;127:235-244
    Primary hyperparathyroidism is primarily due to a solitary parathyroid adenoma but multi-gland disease, parathyroid carcinoma, and ectopic parathyroid hormone production can occur. Although primary hyperparathyroidism mostly presents sporadically, strong familial predispositions also exist. Much is known about heritable genetic mutations responsible for these syndromes, including multiple endocrine neoplasia types 1 and 2A, hyperparathyroidism-jaw tumor syndrome, and familial hypocalciuric hypercalcemia. Read More

    The dangers of parathyroid biopsy.
    J Otolaryngol Head Neck Surg 2017 Jan 7;46(1). Epub 2017 Jan 7.
    Department of Otolaryngology (ENT), Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
    Background: We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement.

    Case Presentation: There was clinical suspicion for parathyroid carcinoma, further supported by intra-operative findings. However, the final pathology described a primary hyperceullar parathyroid lesion with pathognomonic changes secondary to fine-needle aspiration (FNA) biopsy, along with a separate parathyroid lesion likely resulting from seeding along the needle tract. Read More

    G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling.
    DNA Cell Biol 2017 Jan 4. Epub 2017 Jan 4.
    1 Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University , Tianjin, People's Republic of China .
    Heterotrimeric G proteins, which are composed of Gα and Gβγ subunits, transduce signals sensed by the coupled surface receptors. Aberrant expressions of G proteins have been observed in many cancer types. This study aimed to determine the expression level of the stimulatory G protein alpha S subunit (Gαs, the main transcript encoded by the GNAS locus) and its biological function in renal cell carcinoma (RCC). Read More

    A rare case of cutaneous oncocytic hidradenoma.
    J Cutan Pathol 2017 Mar 2;44(3):289-291. Epub 2017 Feb 2.
    Departments of Dermatology and Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
    Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Read More

    Loss of RUNX3 expression inhibits bone invasion of oral squamous cell carcinoma.
    Oncotarget 2016 Dec 21. Epub 2016 Dec 21.
    Department of Dentistry, Graduate School, Yonsei University, Seoul 120-749, Republic of Korea.
    High recurrence and lower survival rates in patients with oral squamous cell carcinoma (OSCC) are associated with its bone invasion. We identified the oncogenic role of RUNX3 during bone invasion by OSCC. Tumor growth and the generation of osteolytic lesions were significantly inhibited in mice that were subcutaneously inoculated with RUNX3-knockdown human OSCC cells. Read More

    Association between the KRAS Gene Polymorphisms and Papillary Thyroid Carcinoma in a Chinese Han Population.
    J Cancer 2016 9;7(15):2420-2426. Epub 2016 Dec 9.
    Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin Province, China.
    Several studies have reported the association between MAPK signaling pathway gene polymorphisms and papillary thyroid carcinoma (PTC). KRAS gene, an oncogene from the mammalian RAS gene family plays an important role in the MAPK pathway. This study aimed to identify the potential association of KRAS gene polymorphisms with susceptibility to PTC in a Han Chinese population. Read More

    Application of carbon nanoparticles accelerates the rapid recovery of parathyroid function during thyroid carcinoma surgery with central lymph node dissection: A retrospective cohort study.
    Int J Surg 2016 Oct 27. Epub 2016 Oct 27.
    Department of General Surgery, Changzheng Hospital affiliated to The Second Military Medical University, Shanghai 200003, China. Electronic address:
    Background And Objectives: The aim of this study was to evaluate the efficacy of carbon nanoparticles in identifying lymph nodes and promoting parathyroid gland function recovery after thyroid carcinoma surgery along with central lymph node dissection.

    Methods: A total of 231 patients who underwent thyroid carcinoma surgery combined with central lymph node dissection were divided into two groups: the CN group (intraoperative carbon nanoparticles injections) and the control group (no injection). Datas were collected respectively on the pre-operative, 1(st), 7(th) and 30(th) postoperative days and monthly thereafter. Read More

    Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT.
    Ann Surg Treat Res 2016 Dec 25;91(6):323-326. Epub 2016 Nov 25.
    Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT). Read More

    Denosumab is Effective for Controlling Serum Calcium Levels in Patients with Humoral Hypercalcemia of Malignancy Syndrome: A Case Report on Parathyroid Hormone-related Protein-producing Cholangiocarcinoma.
    Intern Med 2016;55(23):3453-3457. Epub 2016 Dec 1.
    Department of Internal Medicine, Iida Municipal Hospital, Japan.
    Hypercalcemia resulting in the elevation of serum parathyroid hormone-related protein (PTHrP) and suppression of serum PTH was observed in a patient with advanced cholangiocarcinoma (CCC) and multiple lymph node metastases. We confirmed humoral hypercalcemia of malignancy based on PTHrP-producing CCC. Chemotherapy with gemcitabine and cisplatin could not control the patient's serum PTHrP levels and the patient was affected with bisphosphonate-refractory hypercalcemia. Read More

    Evaluation of preoperative ultrasonographic and biochemical features of patients with aggressive parathyroid disease: is there a reliable predictive marker?
    Arch Endocrinol Metab 2016 Nov-Dec;60(6):537-544. Epub 2016 Nov 24.
    Yildirim Beyazit University, Ataturk Education and Research Hospital, Endocrinology and Metabolism Department, Ankara, Turkey.
    Objective: Parathyroid cancer (PC) represents < 1% of cases of PHPT. Tumors demonstrating atypical histopathologic features and don't fulfill criteria for carcinoma are classified as atypical adenomas (APA). The purpose of this study was to determine a biochemical or ultrasonographic feature that can predict aggressive disease requiring more extensive surgery and closer follow-up. Read More

    A novel thyroid cancer nodal map classification system to facilitate nodal localization and surgical management: The A to D map.
    Laryngoscope 2016 Nov 30. Epub 2016 Nov 30.
    Division of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.
    Objectives/hypothesis: To evaluate the effectiveness, reproducibility, and usability of our proposed nodal nomenclature and classification system employed for several years in our high-volume thyroid cancer unit, for the adequate localization and mapping of lymph nodes in thyroid cancer patients with extensive nodal disease.

    Study Design: Retrospective review.

    Methods: Thirty-three thyroid cancer patients with extensive nodal disease treated from January 2004 to May 2013 were included in our study. Read More

    Metastasis of renal cell carcinoma to the parathyroid gland 16 years after radical nephrectomy: A case report.
    Oncol Lett 2016 Nov 31;12(5):3224-3228. Epub 2016 Aug 31.
    Department of Surgical Pathology, University Hospital of Pisa, Pisa I-56126, Italy.
    Renal cell carcinoma (RCC) has a high metastatic potential, and most commonly metastasizes via the bloodstream, although lymphatic metastases also occur. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after a number of years, is common. The occurrence of RCC metastasis to the head and neck region is uncommon, and occurs primarily in the thyroid gland and in patients with widespread dissemination. Read More

    Trousseau's syndrome caused by bladder cancer producing granulocyte colony-stimulating factor and parathyroid hormone-related protein: A case report.
    Oncol Lett 2016 Nov 20;12(5):4214-4218. Epub 2016 Sep 20.
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan.
    The present study reports a rare case of bladder cancer that caused Trousseau's syndrome, a malignancy-associated hypercoagulative state leading to venous or arterial thrombosis. A 38-year-old Japanese female patient experienced a sudden onset of visual field defects and lower limb weakness. Cerebral magnetic resonance imaging revealed multi-regional hypointense areas compatible with acute cerebral infarction. Read More

    Cinacalcet hydrochloride relieves hypercalcemia in Japanese patients with parathyroid cancer and intractable primary hyperparathyroidism.
    J Bone Miner Metab 2016 Nov 21. Epub 2016 Nov 21.
    Department of Transplant and Endocrine Surgery, Nagoya Second Red Cross Hospital, Nagoya, Japan.
    Pharmacological treatment of hypercalcemia is essential for patients with parathyroid carcinoma and intractable primary hyperparathyroidism (PHPT). Use of the calcimimetic cinacalcet hydrochloride (cinacalcet) is an option to treat such patients. We investigated the efficacy and safety of cinacalcet in Japanese patients with parathyroid carcinoma and intractable PHPT. Read More

    Intraoperative localization of the parathyroid glands with indocyanine green and Firefly(R) technology during BABA robotic thyroidectomy.
    Surg Endosc 2016 Nov 18. Epub 2016 Nov 18.
    Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea.
    Background: It is unclear whether near-infrared (NIR) light-induced indocyanine green (ICG) fluorescence can effectively identify, and thus permit the preservation of, parathyroid glands in bilateral axillo-breast approach (BABA) robotic thyroidectomy. This case-control study with a prospectively recruited consecutive series and a retrospectively selected control group assessed the usefulness of ICG with Firefly(R) technology to identify the parathyroid glands intraoperatively during BABA robotic thyroidectomy.

    Methods: All consecutive patients (N = 22) who were scheduled to undergo BABA robotic thyroidectomy for papillary thyroid carcinoma in December 2013-August 2015 and met the study eligibility criteria were recruited prospectively. Read More

    [Parathyroid disease: The full spectrum, from adenoma to carcinoma. Report of 3 cases].
    Cir Cir 2016 Nov 14. Epub 2016 Nov 14.
    Cirugía general, Centro Médico ABC, Ciudad de México, México. Electronic address:
    Background: Primary hyperparathyroidism is a disease characterised by the autonomous production of parathyroid hormone. The most common cause is an adenoma, followed by hyperplasia, and rarely carcinoma.

    Clinical Cases: Three cases are presented. Read More

    Spontaneous proliferative and neoplastic lesions in thyroid and parathyroid glands of nondomestic felids.
    J Vet Diagn Invest 2017 Jan 16;29(1):8-13. Epub 2016 Nov 16.
    Departments of Biomedical and Diagnostic Sciences (Pope, Reel, Newman), College of Veterinary Medicine, University of Tennessee, Knoxville, TN.
    Based on microscopic and immunohistochemical characterization, we documented spontaneous proliferative and neoplastic lesions in the thyroid and parathyroid glands of nondomestic felids. Ten animals (4 leopards, 3 tigers, and 3 cougars), all with a previous diagnosis of thyroid neoplasia were identified from the University of Tennessee College of Veterinary Medicine database. The mean age of affected animals was 15. Read More

    Minimal Endoscope-assisted Thyroidectomy Through a Retroauricular Approach: An Evolving Solo Surgery Technique.
    Surg Laparosc Endosc Percutan Tech 2016 Dec;26(6):e109-e112
    *Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan †Department of Medicine, The Graduate School of Yonsei University §Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul ‡Department of Otorhinolaryngology, Chungnam National University College of Medicine, Daejeon, Korea.
    This study aimed to evaluate the feasibility and efficacy of minimal endoscope-assisted thyroidectomy (MEAT) through a retroauricular (RA) approach. Most of the thyroidectomy operative time was accounted for by direct visualization through the RA window, minimizing interference between surgical instruments. Endoscope use was minimized and limited to critical surgical aspects, including preservation of the recurrent laryngeal nerve and parathyroid glands. Read More

    The follicular variant of papillary thyroid cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
    Curr Opin Oncol 2017 Jan;29(1):20-24
    aDepartment of Otolaryngology, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio bDivision of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary cDepartment of Pathology, Massachusetts General Hospital dDivision of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new terminology proposed for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). Recently, thyroid cancer incidence has increased dramatically, without affecting related mortality rate. This increase is widely attributed to the intensified surveillance leading to a substantial increase in the diagnosis of small classic papillary thyroid cancers and EFVPTCs. Read More

    Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines.
    J Laryngol Otol 2016 May;130(S2):S150-S160
    The Newcastle upon Tyne Hospitals NHS Foundation Trust,Newcastle upon Tyne,UK.
    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides recommendations on the management of thyroid cancer in adults and is based on the 2014 British Thyroid Association guidelines. Recommendations • Ultrasound scanning (USS) of the nodule or goitre is a crucial investigation in guiding the need for fine needle aspiration cytology (FNAC). Read More

    Surgical Management of Medullary thyroid carcinoma in pediatric age.
    Curr Pediatr Rev 2016 Nov 11. Epub 2016 Nov 11.
    Department of Surgery, University of Pisa, Via Roma 67 56126, Pisa, Italy.
    Medullary thyroid carcinoma (MTC) is a rare, accounting for 5% of thyroid malignancies. It is a neuroendocrine tumor wich origins from thyroid parafollicular cells. It may be sporadic, mostly in adult patients, or inherited as autosomal dominant pattern, mostly in pediatric patients. Read More

    Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma.
    Open Vet J 2016 15;6(3):165-171. Epub 2016 Oct 15.
    Alumna de Programa de Investigación. Fac. de Ciencias Veterinarias, UBA, Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
    Human multiple endocrine neoplasia subtype 2A (MEN 2A) is characterized by medullary thyroid carcinoma, pheochromocytoma and parathyroid hyperplasia or adenoma in the same individual. In this report, a case of a female Rottweiler with medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma was described. Clinical manifestations of muscle weakness, polydipsia, polyuria, diarrhea and weight loss were observed. Read More

    Long-Term Follow-Up and Treatment of Postoperative Permanent Hypoparathyroidism in Patients with Medullary Thyroid Carcinoma: Differences in Complete and Partial Disease.
    Horm Metab Res 2016 Dec 3;48(12):806-813. Epub 2016 Nov 3.
    Endocrine Practice, Heidelberg, Germany.
    This study aimed to identify factors influencing long-term outcome in complete or partial postoperative hypoparathyroidism (parathyroid hormone ≤10 or >10 ng/l, respectively) in medullary thyroid carcinoma (MTC). It was designed as retrospective, long-term follow-up with single-center outpatient visits. Quality of treatment, renal calcification, and function were evaluated. Read More

    A new technique to simplify the minimally invasive parathyroidectomy: Ultrasound-assisted guided wire localization for solitary parathyroid adenomas.
    J Pak Med Assoc 2016 Nov;66(11):1427-1432
    Departments of Endocrinology and Metabolism, Faculty of Medicine, Turkey.
    Objective: To investigate the benefits of ultrasound-assisted guided wire localization in MIP for selected cases.

    Methods: In this prospective, nonrandomised study, we included 36 patients with solitary parathyroid adenomas diagnosed preoperatively by 99m Tc sesta MIBI scintigraphy and/or neck ultrasonography. An ultrasound-guided wire was placed in the solitary parathyroid adenoma preoperatively. Read More

    Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up.
    Otolaryngol Head Neck Surg 2016 Nov 12;155(5):787-789. Epub 2016 Jul 12.
    Department of Surgery and Translational Medicine, Medical School, and Regional Centre for Hereditary Endocrine Tumors, University of Florence, Florence, Italy.
    In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development, but the management of MEN 2A patients diagnosed after childhood is still under debate. Seventeen consecutive patients diagnosed with MEN 2A after the age of 5 years (mean age, 23.3 years) with a pathologic diagnosis of micro-MTC without nodal involvement were enrolled. Read More

    [CDC73 mutations in young patients with primary hyperparathyroidism: A description of two clinical cases].
    Ter Arkh 2016;88(10):57-62
    Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.
    The article describes two clinical cases of severe primary hyperparathyroidism (PHPT) caused by parathyroid carcinoma in young female patients who underwent molecular genetic testing to rule out the hereditary forms of PHPT. In both patients, heterozygous germline nonsense mutations of tumor suppressor gene CDC73 encoding parafibromin (p.R91X and p. Read More

    Animal models of medullary thyroid cancer: state of the art and view to the future.
    Endocr Relat Cancer 2017 Jan 31;24(1):R1-R12. Epub 2016 Oct 31.
    Department of Clinical Medicine and SurgerySection of Endocrinology, 'Federico II' University of Naples, Naples, Italy.
    Medullary thyroid carcinoma is a neuroendocrine tumour originating from parafollicular C cells accounting for 5-10% of thyroid cancers. Increased understanding of disease-specific molecular targets of therapy has led to the regulatory approval of two drugs (vandetanib and cabozantinib) for the treatment of medullary thyroid carcinoma. These drugs increase progression-free survival; however, they are often poorly tolerated and most treatment responses are transient. Read More

    Evaluation of malignant parathyroid tumours in two European cohorts of patients with sporadic primary hyperparathyroidism.
    Langenbecks Arch Surg 2016 Nov 11;401(7):943-951. Epub 2015 Dec 11.
    Department of Surgery, Lukas Hospital, Neuss, Germany.
    Purpose: Parathyroid carcinoma (PC) is remarkable for its rare occurrence and challenging diagnostics. PC accounts for 0.1-5 % cases of primary hyperparathyroidism (PHPT). Read More

    Oncologic progress for the treatment of parathyroid carcinoma is needed.
    J Surg Oncol 2016 Nov 18;114(6):708-713. Epub 2016 Oct 18.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background And Objectives: Parathyroid carcinoma (PC) is rare but potentially lethal. No standardized staging system or treatment guidelines have been established. We aimed to determine whether management of PC and patient outcomes have changed at our institution over the past 35 years. Read More

    Pathologic Fracture of the Femur in Brown Tumor Induced in Parathyroid Carcinoma: A Case Report.
    Hip Pelvis 2016 Sep 30;28(3):173-177. Epub 2016 Sep 30.
    Department of Orthopaedic Surgery, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
    Brown tumor refers to a change of skeletones that develops as a complication of hyperparathyroidism. As osteoclast is activated to stimulate reabsorption and fibrosis of bone, it causes a cystic change of the bone. Parathyroid carcinoma is being reported as a tumor that induces primary hyperparathyroidism. Read More

    Expression of TRAIL and Fas in Primary Hyperparathyroidism.
    J Invest Surg 2016 Oct 20:1-5. Epub 2016 Oct 20.
    a Department of Histology and Embryology , School of Medicine with the Division of Dentistry, Medical University of Silesia , Jordana 19, Zabrze , Poland.
    Aim: Differentiating between parathyroid lesions is still difficult and ambiguous. In cases of primary hyperparathyroidism, appropriate and prompt diagnosis is of great importance for effective treatment and follow-up. A great amount of mechanisms contribute to the pathogenesis of primary hyperparathyroidism, such as disturbance in balance between pro- and anti-apoptotic factors. Read More

    Potential role of carbon nanoparticles in protection of parathyroid glands in patients with papillary thyroid cancer.
    Medicine (Baltimore) 2016 Oct;95(42):e5002
    aKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Head and Neck Surgery, Peking University Cancer Hospital & Institute, Beijing bDepartment of Oral and Maxillofacial Surgery, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China cDepartment of Head and Neck Surgery dDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX.
    As a novel type of lymphatic tracer, carbon nanoparticles (CNs) were reported not to stain parathyroid glands (PGs) into black, so it may have a clinical potential in protection of PGs during thyroidectomy. The purpose of this study was to investigate the clinical application and significance of CN in protection of PGs from surrounding tissues.A total of 82 consecutive patients were enrolled into this study and were divided into CN group and control group. Read More

    Acute presentation of a giant intrathyroidal parathyroid adenoma: a case report.
    J Med Case Rep 2016 Oct 19;10(1):286. Epub 2016 Oct 19.
    Department of Endocrinology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.
    Background: We report the case of a giant intrathyroidal parathyroid adenoma weighing 59 g in a young woman presenting acutely with severe hypercalcemia requiring correction and adequate preoperative management prior to surgery. Parathyroid adenomas account for 85 % of cases of primary hyperparathyroidism. Those weighing more than 3. Read More

    The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism.
    JAMA Surg 2016 Oct;151(10):959-968
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
    Importance: Primary hyperparathyroidism (pHPT) is a common clinical problem for which the only definitive management is surgery. Surgical management has evolved considerably during the last several decades.

    Objective: To develop evidence-based guidelines to enhance the appropriate, safe, and effective practice of parathyroidectomy. Read More

    Prospective evaluation of intra-operative quick parathyroid hormone assay as an early predictor of post thyroidectomy hypocalcaemia.
    Int J Surg 2016 Oct 12;34:103-108. Epub 2016 Aug 12.
    Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, India.
    Background: Hypocalcaemia following total thyroidectomy is a major contributing factor in delayed hospital discharge and dissuading surgeons from day care thyroidectomy. We prospectively evaluated the utility of Intra-operative serum quick parathyroid hormone level measurement twenty minutes after total thyroidectomy in predicting post-operative hypocalcemia.

    Material And Methods: Prospective longitudinal study which included patients undergoing total thyroidectomy for benign or malignant thyroid disorders at SGPGIMS, Lucknow, India from November 2013 to February 2015. Read More

    EZH2 and ZFX oncogenes in malignant behaviour of parathyroid neoplasms.
    Endocrine 2016 Oct 15;54(1):55-59. Epub 2016 Feb 15.
    Medical Genetics, Poliambulatorio Giovanni Paolo II, IRCCS Casa Sollievo della Sofferenza Hospital, 71013, San Giovanni Rotondo, FG, Italy.
    Several studies reported somatic mutations of many genes (MEN1, CTNNB1, CDKIs and others) in parathyroid adenoma, although with different prevalence. Recently, activating mutations of the EZH2 and ZFX oncogenes were identified in benign parathyroid adenoma by whole exome sequencing. The same mutations had been found in blood and ovary malignant tumours. Read More

    Association of the preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with lymph node metastasis and recurrence in patients with medullary thyroid carcinoma.
    Medicine (Baltimore) 2016 Oct;95(40):e5079
    aThyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China bState Key Laboratory of Biotherapy/Collaborative Innovation Centre of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.
    The preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are known to be prognostic factors in several cancers. However, no previous investigation has been performed to evaluate the significance of the NLR and PLR in medullary thyroid carcinoma (MTC).The aim of this study was to identify the ability of the preoperative NLR or PLR to predict lymph node metastasis and recurrence in patients with MTC. Read More

    Spectrum of AIDS defining & non-AIDS defining malignancies in north India.
    Indian J Med Res 2016 May;143(Supplement):S129-S135
    Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
    Background & Objectives: There is scarcity of data on the frequency of malignancies in HIV infected individuals from India. The objective of this study was to determine the type and frequency of malignancies in HIV infected individuals attending a tertiary care hospital in north India.

    Methods: The study design included retrospective analysis of data of all HIV infected individuals registered in the Immunodeficiency clinic from December 2009 to December 2011 and a prospective analysis of HIV infected individuals registered from January 2012 to April 2013. Read More

    Association of parathyroid carcinoma and thyroid disorders: A clinical review.
    Endocrine 2016 Oct 15. Epub 2016 Oct 15.
    Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.
    Parathyroid carcinoma is a rare malignancy, which usually occurs as a sporadic disease, and less frequently in the setting of genetic syndromes. Despite the association of parathyroid and thyroid disorders being quite common, the coexistence of parathyroid carcinoma and thyroid disease is rare. We reviewed the pertinent literature. Read More

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