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    1 OF 247

    Surgical approaches in hereditary endocrine tumors.
    Updates Surg 2017 Apr 28. Epub 2017 Apr 28.
    Minimally Invasive Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
    Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. Read More

    Concomitant thyroid cancer in patients with primary hyperparathyroidism in an endemic goitre region.
    Ann Ital Chir 2017 ;88:15-19
    Objective: Primary hyperparathyroidism (pHPT) is often accompanied by underlying thyroid pathology and 1 to 36% of these thyroid pathologies are malignant. How the identification of these lesions affects patient management is unclear. We present a single-center experience with the prevalence of concomitant thyroid cancer in patients who underwent parathyroidectomy for pHPT. Read More

    Persistent and recurrent hyperparathyroidism.
    Updates Surg 2017 Apr 22. Epub 2017 Apr 22.
    Department of Endocrine Surgery, La Conception Hospital, Assistance Publique Hopitaux de Marseille, 147 BD Baille, 13005, Marseille, France.
    Despite remarkable progress in imaging modalities and surgical management, persistence or recurrence of primary hyperparathyroidism (PHPT) still occurs in 2.5-5% of cases of PHPT. The aim of this review is to expose the management of persistent and recurrent hyperparathyroidism. Read More

    Prognostic Scoring System to Risk Stratify Parathyroid Carcinoma.
    J Am Coll Surg 2017 Mar 15. Epub 2017 Mar 15.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Background: Parathyroid carcinoma is a rare endocrine malignancy that lacks an established system for risk categorization. This study evaluated a prognostic scoring system for recurrence-free survival (RFS) of patients with parathyroid carcinoma.

    Study Design: Patients diagnosed and confirmed to have parathyroid carcinoma and who were treated between 1980 and 2016 at The University of Texas MD Anderson Cancer Center were studied retrospectively. Read More

    The many guises of primary hyperparathyroidism: An unchanged scenario.
    J Pak Med Assoc 2017 Apr;67(4):580-585
    Medical Unit-II, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
    Objective: To study the causes, characteristics and outcome of treatment of patients with primary hyperparathyroidism.

    Methods: This retrospective cohort analysis was conducted at the Jinnah Postgraduate Medical Centre, Karachi, and comprised data of patients with primary hyperparathyroidism between 2004 and 2014. . Read More

    Epigenetic processes in sporadic parathyroid neoplasms.
    Mol Cell Endocrinol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States. Electronic address:
    Parathyroid tumors (PTs) are highly variable in their genetic background. Increasing evidence demonstrates that endocrine diseases can be caused by epigenetic alterations. The present review is focused on epigenetic aberrations related to PTs. Read More

    18F-Fluorocholine, 18F-FDG, and 18F-Fluoroethyl Tyrosine PET/CT in Parathyroid Cancer.
    Clin Nucl Med 2017 Apr 7. Epub 2017 Apr 7.
    From the *Clinical Institute of Nuclear Medicine and Endocrinology, and †Central Radiology Institute, Kepler University Hospital, Med. Campus III, Linz, Austria; ‡Medical Faculty of the University of Erlangen, Germany; and §Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
    We report on a 71-year-old woman presenting with biochemical features indicating recurrent disease in long-term follow-up of left-sided parathyroid carcinoma. She had undergone several surgical procedures including total thyroidectomy, partial resection of the esophageal wall, and curative neck radiation 12 years previously. PET/CT using F-fluorocholine revealed high uptake in local relapse in the lower neck, comparable to F-FDG, whereas only faint uptake was observed with F-fluoroethyl tyrosine. Read More

    Circulating tumor cells and miRNA as prognostic markers in neuroendocrine neoplasms.
    Endocr Relat Cancer 2017 Apr 7. Epub 2017 Apr 7.
    A Colao, Molecular and Clinical Endocrinology and Oncology, Federico II University, Napoli, Italy.
    The prognosis of neuroendocrine neoplasms (NENs) is widely variable and has been shown to associate with several tissue- and blood-based biomarkers in different settings. The identification of prognostic factors predicting NEN outcome is of paramount importance to select the best clinical management for these patients. Prognostic markers have been intensively investigated, also taking advantage of the most modern techniques, in the perspective of personalized medicine and appropriate resource utilization. Read More

    Effects of sample storage and diluents in the reliability of thyroglobulin measurement in the washout of fine needle aspirates.
    Endocrine 2017 Apr 6. Epub 2017 Apr 6.
    Division of Endocrinology, Hospital "J.M. Ramos Mejía", Gral. Urquiza 609, Buenos Aires, 1221, Argentina.
    Objective: To evaluate two variables affecting Thyroglobulin stability in the washout of fine needle aspiration biopsies of thyroid nodules and metastatic lymph nodes.

    Materials And Methods: Thyroglobulin stability after storage at -20 °C up to 14 days was studied in washout performed with normal saline solution and further dilutions with normal saline solution from five metastatic thyroid nodes and six benign thyroid nodules. We also studied thyroglobulin stability in diluents compared with normal saline solution: 4% bovine serum albumin in normal saline solution and diluents free from thyroglobulin or Calcitonin or parathyroid hormone in paired and simultaneous thyroglobulin measurements of washout dilutions from 5/6 benign thyroid nodules and 2/5 metastatic lymph nodes. Read More

    RSK activation via ERK modulates human colon cancer cells response to PTHrP.
    J Mol Endocrinol 2017 Apr 6. Epub 2017 Apr 6.
    C Gentili, Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, Bahia Blanca, Argentina
    Parathyroid Hormone-related Peptide (PTHrP) is associated with several human cancers such as colon carcinoma. This disease is a complex multistep process that involves enhanced cell cycle progression and migration. Recently we obtained evidence that in the human colorectal adenocarcinoma Caco-2 cells, exogenous PTHrP increases the proliferation and positively modulates cell cycle progression via ERK1/2, p38 MAPK and PI3K. Read More

    Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism.
    Int J Surg Pathol 2017 Apr 1:1066896917701577. Epub 2017 Apr 1.
    1 Mount Sinai Medical Center, Miami Beach, FL, USA.
    Water clear cell adenoma of the parathyroid gland is a rare neoplasm composed of large clear cells with foamy cytoplasm and mild nuclear pleomorphism, compressing the residual nonneoplastic parathyroid tissue. The differential diagnosis includes a variety of neoplasms with clear cell features. In this article, we provide an overview of the entity with a historical perspective, in order to help pathologists in distinguishing it from other neoplasms in their daily practice. Read More

    Staged Surgery for Advanced Thyroid Cancers: Safety and Oncologic Outcomes of Neural Monitored Surgery.
    Otolaryngol Head Neck Surg 2017 Apr 1:194599817697189. Epub 2017 Apr 1.
    1 Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary & Harvard Medical School, Boston, Massachusetts, USA.
    Objective Thyroidectomy with extensive multicompartment bilateral neck dissections for advanced-stage thyroid cancer may lead to increased risk of complications, including bilateral recurrent laryngeal nerve (RLN) paralysis and hypoparathyroidism. A planned staged approach derived from a detailed preoperative radiographic map is associated with a low complication profile. This study evaluates oncologic results and safety of neural monitored, staged thyroid cancer surgery for management of advanced thyroid cancer. Read More

    Less is more: time to expand the indications for minimally invasive video-assisted parathyroidectomy.
    J Endocrinol Invest 2017 Apr 3. Epub 2017 Apr 3.
    Division of Endocrine Surgery, Department of Surgical Pathology, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.
    Purpose: Minimally invasive video-assisted parathyroidectomy (MIVAP) is one of the most widespread targeted parathyroid surgeries for primary hyperparathyroidism (PHP). The aim of this study was to assess its limits and propose an expansion of its indications in the management of parathyroid pathology.

    Methods: A retrospective analysis of 77 consecutive patients who underwent MIVAP for PHP between Jan and Oct 2016 was conducted. Read More

    A nationwide study on parathyroid carcinoma.
    Acta Oncol 2017 Mar 31:1-13. Epub 2017 Mar 31.
    a The Division of Endocrinology , Abdominal Center, University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
    Background: Parathyroid carcinoma (PC) is rare and diagnostically challenging. Reported outcomes are rather poor and the incidence might be increasing.

    Material And Methods: We performed a nationwide study on all cases (n= 32) diagnosed in 2000-2011 in Finland, and compared clinical and histopathological characteristics and outcome to atypical parathyroid (APA; n= 28) and parathyroid adenomas (PA; n= 72). Read More

    Apoptosis in Primary Hyperparathyroidism.
    J Invest Surg 2017 Mar 31:1-5. Epub 2017 Mar 31.
    a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
    Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. Read More

    Genomic profiling reveals mutational landscape in parathyroid carcinomas.
    JCI Insight 2017 Mar 23;2(6):e92061. Epub 2017 Mar 23.
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Parathyroid carcinoma (PC) is an extremely rare malignancy lacking effective therapeutic intervention. We generated and analyzed whole-exome sequencing data from 17 patients to identify somatic and germline genetic alterations. A panel of selected genes was sequenced in a 7-tumor expansion cohort. Read More

    Incidental metastatic mediastinal atypical carcinoid in a patient with parathyroid adenoma: a case report.
    J Med Case Rep 2017 Mar 26;11(1):81. Epub 2017 Mar 26.
    Department of Ear, Nose & Throat, Aga Khan University Hospital, Stadium Road, Karachi, Pakistan.
    Background: Atypical carcinoid arising from the mediastinal tissue is a rare neuroendocrine tumor and an association with parathyroid adenoma is very unusual. We report an unusual case of atypical carcinoid of mediastinum with metastasis in a patient presenting with parathyroid adenoma, which is the first case to be reported from Pakistan.

    Case Presentation: A 51-year-old Pakistani man was seen in postoperative intensive care after right parathyroidectomy and mediastinal mass resection for the management of postoperative hypocalcaemia. Read More

    Lung carcinoma progression and survival versus amino- and carboxyl-parathyroid hormone-related protein expression.
    J Cancer Res Clin Oncol 2017 Mar 25. Epub 2017 Mar 25.
    Pathology Service, VA San Diego Healthcare System, San Diego, USA.
    Purpose: Expression of the carboxyl PTHrP region of parathyroid hormone-related protein (PTHrP) is a positive prognostic indicator in women with lung cancer, but amino PTHrP is a negative indicator in other lung cancer patients. This project investigated whether PTHrP could be expressed as predominantly amino PTHrP or carboxyl PTHrP in individual lung carcinomas. It also assessed domain-specific effects on cancer progression and patient survival. Read More

    [Parathyroid cancer].
    Vnitr Lek 2017 ;63(2):139-144
    Parathyroid cancer is a rare endocrine malignancy, representing less than 1 % of all cases of primary hyperparathyroidism. The exact etiology of the disease remains unknown. Known risk factors include neck irradiation, end stage renal failure, genetic factors, particularly the the HPRT2/CDCT73 gene mutation. Read More

    Unintentional parathyroidectomy during total thyroidectomy surgery: A single surgeon's experience.
    Medicine (Baltimore) 2017 Mar;96(11):e6411
    aDepartment of Head Neck, First Affiliated Hospital of Zhengzhou University bDepartment of Head Neck and Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, PR China.
    In this study, we investigated incidental parathyroidectomy during total thyroidectomy surgery that required central lymph node dissection and the potential risk factors. Patients requiring total thyroidectomy and tracheoesophageal groove node dissection were enrolled in the study from January 2013 to June 2015 and we obtained all medical information, including pathology reports. Furthermore, we recorded the parathyroid hormone level in all patients prior to operation and then 3 further times: 1 day, 1 week, and 3 months after surgery. Read More

    Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.
    Oncogene 2017 Mar 13. Epub 2017 Mar 13.
    Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.
    The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malignant neoplasms. HPT-JT is caused by mutations of the cell division cycle 73 (CDC73) gene, located on chromosome 1q31.2 and encodes a 531 amino acid protein, parafibromin. Read More

    Preoperative ultrasound-guided carbon nanoparticles localization for metastatic lymph nodes in papillary thyroid carcinoma during reoperation: A retrospective cohort study.
    Medicine (Baltimore) 2017 Mar;96(10):e6285
    aDepartment of Thyroid & Parathyroid Surgery bDepartment of Ultrasound, West China Hospital cWest China School of Stomotology, Sichuan University, Chengdu, PR China.
    Due to the damaged anatomical structure and a large amount of fibrous and scar tissues in the surgical field, reoperation of papillary thyroid carcinoma is difficult. This study introduces a new method of locating metastatic lymph nodes during reoperation and evaluates the effectiveness and safety of the preoperative ultrasound-guided carbon nanoparticles (CNs) localization. This retrospective cohort study enrolled 52 patients who were diagnosed with lymph node metastasis by histopathology and underwent reoperation from October 2015 to February 2016. Read More

    Preoperative predictors of lateral neck lymph node metastasis in papillary thyroid microcarcinoma.
    Medicine (Baltimore) 2017 Mar;96(10):e6240
    aThyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zheng Zhou bThyroid and Parathyroid Center, West China Hospital of Sichuan University, Chengdu, China.
    Lateral lymph node metastasis (LNM) is not uncommon in papillary thyroid microcarcinoma (PTMC). Our present study aimed to investigate the risk factors associated with lateral LNM in PTMC.We retrospectively collected data pertaining to 366 patients with PTMC who underwent surgery at our center from 2010 to 2015. Read More

    Mapping the distribution of nodal metastases in papillary thyroid carcinoma: Where exactly are the nodes?
    Laryngoscope 2017 Mar 8. Epub 2017 Mar 8.
    Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.
    Objective: To characterize nodal disease of patients presenting with papillary thyroid carcinoma (PTC) STUDY DESIGN: Retrospective chart review.

    Methods: PTC patients who underwent thyroidectomy and/or neck dissection (revision/primary) from 2004 to 2009 at a tertiary-care hospital were reviewed. Preoperative computed tomography (CT) scan and ultrasonography were utilized to identify macroscopic, clinically apparent nodal metastasis (cN+). Read More

    A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.
    BMC Gastroenterol 2017 Mar 7;17(1):37. Epub 2017 Mar 7.
    Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
    Background: In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. Treatment for his esophageal stricture and ZES was discussed. Read More

    Parathyroid Adenomas in Adults and Adolescents. Critical Appraisal and Surgical Strategy in 18 Cases.
    Chirurgia (Bucur) 2017 Jan-Feb;112(1):18-24
    Background: Our study underline scarcity of isolated case reports or small case series of parathyroid adenoma (PA) published in autochthonous medical literature,their variable clinical expression among the "historic" varieties but also the diagnostic difficulties and delays of diagnosis as well consecration of surgery as the golden therapeutic standard of this disorder.

    Patients And Method: Demographic, clinical presentations, laboratory and imaging data, operative findings and procedures together with pathology account and outcome from the case reports of 18 patients with documented PHP were retrospectively analyzed. Results: The male/female ratio was 1/5, with ages ranging from 16 to 58 (mean 46) years. Read More

    Skip lateral lymph node metastasis leaping over the central neck compartment in papillary thyroid carcinoma.
    Oncotarget 2017 Feb 16. Epub 2017 Feb 16.
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu 610041, China.
    Objective: This study was performed to investigate the frequency and pattern as well as the predictive factors of skip metastasis (lateral cervical lymph node metastasis without central lymph node metastasis) in papillary thyroid carcinoma (PTC).

    Methods: 450 PTC patients who received total thyroidectomy with central neck dissection(CND) combined with modified radical lateral neck dissection(LND) were divided into two groups: with or without skip metastases. The clinicopathological characteristics were statistically compared and analyzed, and univariate and multivariate analyses were performed to detect the risk factors of skip metastasis. Read More

    Fine needle cytology pre-surgical differentiation of parathyroid neoplasms: Is it reliable?
    Cytopathology 2017 Feb 20. Epub 2017 Feb 20.
    Azienda Ospedaliera Universitaria "San Giovanni di Dio e Ruggi d' Aragona", Salerno, Italy.
    Background: Fine needle cytology (FNC) of a parathyroid neoplasia (PN) is reliable, but needs to be confirmed by Parathormone (PTH) and Thyroglobulin (TG) immunoassay on needle washing or by immunocytochemistry (ICC) evaluation. The differentiation between parathyroid adenoma (PA), atypical adenoma (PAA) and carcinoma (PC) is difficult on histology or even impossible on FNC. The aim of this study was to evaluate possible cytological criteria to classify FNC-PN further. Read More

    Synchronous papillary thyroid carcinoma and breast ductal carcinoma: A rare case report and literature review.
    Medicine (Baltimore) 2017 Feb;96(7):e6114
    aDepartment of Pathology, West China Hospital of Sichuan University bThyroid and Parathyroid Surgery Group, West China Hospital of Sichuan University, Chengdu 610041, China.
    Background: The incidences of both thyroid cancer and breast cancer have been rising in recent years; however, it is very rare to find a single person with both of these cancers. Only a few cases of synchronous thyroid and breast cancer have been published, and even fewer cases have been reported in older patients (>60 years).

    Case Summary: The current study presents a case of synchronous papillary thyroid carcinoma and breast ductal carcinoma in an elderly patient. Read More

    Atypical parathyroid adenoma.
    Indian J Pathol Microbiol 2017 Jan-Mar;60(1):99-101
    Department of Pathology, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India.
    Parathyroid lesions clinically manifest themselves in the form of primary hyperparathyroidism most of the times. Parathyroid adenoma constitutes one of the important causes of the same. Although rare, they pose considerable diagnostic dilemma to the pathologist. Read More

    Liver-Directed Embolization for the Long-Term Control of Hypercalcemia of Malignancy in Metastatic Breast Cancer.
    Cancer Control 2017 Jan;24(1):57-59
    Department of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Division of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL.
    Hypercalcemia of malignancy is a common complication of certain types of cancers. No standard therapies exist for the treatment of hypercalcemia secondary to paraneoplastic syndromes that result in the long-term control of serum calcium levels. We report a case of metastatic breast cancer with parathyroid hormone-related protein associated with hypercalcemia of malignancy that was treated with transarterial embolization of the hepatic metastatic lesions. Read More

    Epigenetic Alterations in Parathyroid Cancers.
    Int J Mol Sci 2017 Feb 1;18(2). Epub 2017 Feb 1.
    Endocrinology Unit, Department of Biomedical Sciences for Health, University of Milan, IRCCS Istituto Ortopedico Galeazzi, 20097 Milan, Italy.
    Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. Read More

    Preoperative adjuvant transarterial chemoembolization cannot improve the long term outcome of radical therapies for hepatocellular carcinoma.
    Sci Rep 2017 Feb 3;7:41624. Epub 2017 Feb 3.
    Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China.
    Combinations of transarterial chemoembolization (TACE) and radical therapies (pretransplantation, resection and radiofrequency ablation) for hepatocellular carcinoma (HCC) have been reported as controversial issues in recent years. A consecutive sample of 1560 patients with Barcelona Clinic Liver Cancer (BCLC) stage A/B HCC who underwent solitary Radiofrequency ablation (RFA), resection or liver transplantation (LT) or adjuvant pre-operative TACE were included. The 1-, 3- and 5-year overall survival rates and tumor-free survival rates were comparable between the solitary radical therapy group and TACE combined group in the whole group and in each of the subgroups (RFA, resection and LT) (P > 0. Read More

    Parathyroid Adenoma Mimicking a Malignant Lymph Node on 18F-Choline PET-CT.
    Clin Nucl Med 2017 Apr;42(4):e207-e209
    From the *Department of Nuclear Medicine, University Hospital Ghent, Ghent; †Department of Oncology, AZ Sint-Lucas, Bruges; ‡Department of Uro-oncology, University Hospital Ghent, Ghent; and §Department of Nuclear Medicine, AZ Sint-Lucas, Bruges, Belgium.
    Prostate carcinoma is the most common cancer in men. After local therapy, disease recurs in many patients. A choline PET/CT is indicated in case of biochemical relapse of prostate carcinoma to determine the site of recurrence (local and/or distant) and to help select the next line of therapy. Read More

    Primary Hyperparathyroidism: Effects on Bone Health.
    Endocrinol Metab Clin North Am 2017 Mar 14;46(1):87-104. Epub 2016 Dec 14.
    Section of Endocrine Surgery, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, 72-250 CHS, Los Angeles, CA 90095, USA. Electronic address:
    Primary hyperparathyroidism (PHPT) is the most common cause of chronic hypercalcemia. With the advent of routine calcium screening, the classic presentation of renal and osseous symptoms has been largely replaced with mild, asymptomatic disease. In hypercalcemia caused by PHPT, serum parathyroid hormone levels are either high, or inappropriately normal. Read More

    Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation.
    Sci Rep 2017 Jan 25;7:41131. Epub 2017 Jan 25.
    National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
    Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role of RUNX2/PTHLH axis, which is stimulated HNSCC cell growth. Read More

    Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families.
    Medicine (Baltimore) 2017 Jan;96(3):e5967
    aDepartment of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, PR China bDepartment of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA.
    Backgroud: Multiple endocrine neoplasia type 2A (MEN2A) is a condition with inherited autosomal dominant mutations in RET (rearranged during transfection) gene that predisposes the carrier to extremely high risk of medullary thyroid cancer (MTC) and other MEN2A-associated tumors such as parathyroid cancer and/or pheochromocytoma. Little is reported about MEN2A syndrome in the Chinese population.

    Methods: All members of the 3 families along with specific probands of MEN2A were analyzed for their clinical, laboratory, and genetic characteristics. Read More

    Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1.
    Respir Med Case Rep 2017 18;20:77-81. Epub 2016 Dec 18.
    Department of Internal Medicine, Ojiya General Hospital, Niigata, Japan; Center of Diabetes, Endocrinology and Metabolism, Joetsu General Hospital, Niigata, Japan.
    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by heterozygous germline mutations in the tumor suppressor gene MEN1, which encodes a nuclear protein, menin. MEN1 is characterized by the combined occurrence of tumors involving the pituitary gland, pancreatic islets, and parathyroid glands. Additionally, patients with MEN1 often exhibit adrenal tumors. Read More

    MAJOR MOLECULAR GENETIC DRIVERS IN SPORADIC PRIMARY HYPERPARATHYROIDISM.
    Trans Am Clin Climatol Assoc 2016 ;127:235-244
    FARMINGTON, CONNECTICUT.
    Primary hyperparathyroidism is primarily due to a solitary parathyroid adenoma but multi-gland disease, parathyroid carcinoma, and ectopic parathyroid hormone production can occur. Although primary hyperparathyroidism mostly presents sporadically, strong familial predispositions also exist. Much is known about heritable genetic mutations responsible for these syndromes, including multiple endocrine neoplasia types 1 and 2A, hyperparathyroidism-jaw tumor syndrome, and familial hypocalciuric hypercalcemia. Read More

    The dangers of parathyroid biopsy.
    J Otolaryngol Head Neck Surg 2017 Jan 7;46(1). Epub 2017 Jan 7.
    Department of Otolaryngology (ENT), Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
    Background: We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement.

    Case Presentation: There was clinical suspicion for parathyroid carcinoma, further supported by intra-operative findings. However, the final pathology described a primary hyperceullar parathyroid lesion with pathognomonic changes secondary to fine-needle aspiration (FNA) biopsy, along with a separate parathyroid lesion likely resulting from seeding along the needle tract. Read More

    Humoral Hypercalcemia in Uterine Cancers: A Case Report and Literature Review.
    Am J Case Rep 2017 Jan 6;18:22-25. Epub 2017 Jan 6.
    Department of Medicine, Division of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY, USA.
    BACKGROUND Paraneoplastic hypercalcemia is a well-described complication associated with a variety of malignancies. However, its incidence in gynecological malignancies is low. CASE REPORT A 53-year-old woman presented with progressive abdominal distention and irregular vaginal bleeding of several weeks' duration. Read More

    G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling.
    DNA Cell Biol 2017 Mar 4;36(3):237-242. Epub 2017 Jan 4.
    1 Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University , Tianjin, People's Republic of China .
    Heterotrimeric G proteins, which are composed of Gα and Gβγ subunits, transduce signals sensed by the coupled surface receptors. Aberrant expressions of G proteins have been observed in many cancer types. This study aimed to determine the expression level of the stimulatory G protein alpha S subunit (Gαs, the main transcript encoded by the GNAS locus) and its biological function in renal cell carcinoma (RCC). Read More

    A rare case of cutaneous oncocytic hidradenoma.
    J Cutan Pathol 2017 Mar 2;44(3):289-291. Epub 2017 Feb 2.
    Departments of Dermatology and Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
    Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Read More

    Incremental Value of 18F-Fluorocholine PET/CT in the Localization of Double Parathyroid Adenomas.
    Clin Nucl Med 2017 Mar;42(3):218-220
    From the *Unité thyroïde, Institut Jean Godinot, Reims; †Service d'endocrinologie, diabétologie, nutrition, ‡Service de chirurgie digestive et endocrinienne, and §Laboratoire d'anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims; ∥Service de médecine nucléaire, Institut Jean Godinot, Reims; ¶Laboratoire de Biophysique, UFR de médecine, Université de Reims Champagne Ardenne; and **CRESTIC EA 3804, Université de Reims Champagne Ardenne.
    A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography. Read More

    Loss of RUNX3 expression inhibits bone invasion of oral squamous cell carcinoma.
    Oncotarget 2017 Feb;8(6):9079-9092
    Department of Dentistry, Graduate School, Yonsei University, Seoul 120-749, Republic of Korea.
    High recurrence and lower survival rates in patients with oral squamous cell carcinoma (OSCC) are associated with its bone invasion. We identified the oncogenic role of RUNX3 during bone invasion by OSCC. Tumor growth and the generation of osteolytic lesions were significantly inhibited in mice that were subcutaneously inoculated with RUNX3-knockdown human OSCC cells. Read More

    Is intraoperative parathyroid hormone monitoring necessary for primary hyperparathyroidism with concordant preoperative imaging?
    Am J Surg 2017 Mar 23;213(3):484-488. Epub 2016 Nov 23.
    Case Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Surgery, MetroHealth Medical Center, Cleveland, OH, USA. Electronic address:
    Background: The purpose of this study was to determine if intraoperative parathyroid hormone (PTH) monitoring is necessary in patients with concordant ultrasound and sestamibi imaging.

    Methods: Clinical factors, intraoperative findings and outcome were correlated with imaging results in patients with primary hyperparathyroidism who underwent parathyroidectomy with concordant ultrasound and sestamibi imaging.

    Results: There were 127 patients with primary hyperparathyroidism and concordant imaging who underwent parathyroidectomy. Read More

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