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    12356 results match your criteria Parathyroid Carcinoma

    1 OF 248

    A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid.
    Int J Surg Case Rep 2017 Jun 17;37:83-86. Epub 2017 Jun 17.
    Surgical Oncologist, Department of Surgery, Texas Tech University School of Medicine, Amarillo, TX, USA. Electronic address:
    Introduction: Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH). To date no report of a follicular adenoma with OM and mature EBF in the absence of EMH has been reported in the English language.

    Presentation Of Case: 63-year-old woman with an incidental finding of thyroid nodule unable to be biopsied. Read More

    A role for TET2 in parathyroid carcinoma.
    Endocr Relat Cancer 2017 Jul;24(7):309-318
    Department of Surgical SciencesEndocrine Unit, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Primary hyperparathyroidism (pHPT) is rarely caused by parathyroid carcinoma (PC, <1-5% of pHPT cases). The TET proteins oxidize the epigenetic mark 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and inactivation by mutation or epigenetic deregulation of TET1 and TET2 play important roles in various cancers. Recently, we found that 5hmC was severely reduced in all of the analyzed PCs and with deranged expression of TET1 for the majority of PCs. Read More

    Lymph node metastasis characteristics of papillary thyroid carcinoma located in the isthmus: A single-center analysis.
    Medicine (Baltimore) 2017 Jun;96(24):e7143
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China.
    The frequency and pattern of lymph node metastasis and the extent of dissection for isthmic papillary thyroid carcinoma (PTC) remain unclear, and the aim of this present study was to evaluate these characteristics and to attempt to detect the best surgical protocol for isthmic PTCs. A total of 3185 consecutive patients with PTCs were reviewed. Of these patients, 47 with a single isthmic PTC were enrolled in our study, and matched 47 patients with a single PTC located in the unilateral lobe were randomly selected and added for comparison of their baseline tumor characteristics and lymph node metastasis characteristics. Read More

    Value of 99mTc-MIBI SPECT/CT parathyroid imaging and ultrasonography for concomitant thyroid carcinoma.
    Nucl Med Commun 2017 Jun 13. Epub 2017 Jun 13.
    Departments of aNuclear Medicine bEndocrine and Metabolic Diseases, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Purpose: We aimed to assess the frequency of carcinoma in cases with suspected parathyroid adenoma and test the value of Tc-methoxyisobutylisonitrile (Tc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) parathyroid imaging and neck ultrasonography in detecting concomitant thyroid carcinoma.

    Patients And Methods: We enrolled 741 patients with clinically suspected parathyroid adenoma who underwent Tc-MIBI planer scans and SPECT/CT of the skull base, neck, and thorax; patients also underwent ultrasonography within 1 month before SPECT/CT. Each case with suspected lesion was analyzed and correlated with pathology. Read More

    Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.
    Biomed Pharmacother 2017 Aug 9;92:843-848. Epub 2017 Jun 9.
    Department of Oncological Surgical and Gastroenterological Sciences (DiSCOG), University of Padova, Padova, Italy.
    Objective: Sporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. Read More

    Hypercalcemia due to Nasopharyngeal Carcinoma.
    JNMA J Nepal Med Assoc 2017 Jan-Mar;56(205):182-185
    Department of Pediatrics & Adolescent Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal.
    Hypercalcemia is a rare metabolic disorder associated with hyperparathyroidism, malignancy and various other causes. Although common in adult malignancies, hypercalcemia is rare in pediatrics and purports poor prognosis. Nasopharyngeal carcinoma is rare with no reported hypercalcemic presentation. Read More

    Benign and Malignant Thyroid Gland Diseases in the Patients with Primary Hyperparathyroidism.
    Int J Appl Basic Med Res 2017 Apr-Jun;7(2):117-120
    Department of Endocrinology and Metabolism, Medical Faculty, Trakya University, Edirne, Turkey.
    Introduction: This study aimed to evaluate concurrently detected thyroid pathologies in the patients who underwent surgery for primary hyperparathyroidism (PHPT).

    Materials And Methods: In this study, we retrospectively analyzed the files of the patients who underwent surgery for PHPT between 2012 and 2015. Pre- and post-operative laboratory examination results and preoperative radiological and nuclear medicine findings of the patients were retrospectively recorded. Read More

    Papillary carcinoma of the thyroid in patients with primary hyperparathyroidism: Is there a link?
    Med Hypotheses 2017 Jun 26;103:100-104. Epub 2017 Apr 26.
    Diabetes and Endocrinology, Thomas Addison Unit, St George's Healthcare NHS Trust, London, UK. Electronic address:
    Primary hyperparathyroidism (PHPT) is present in up to 0.1% of the general population. The incidence is higher in women and increases with age. Read More

    Hypercalcaemic encephalopathy due to metastatic parathyroid carcinoma.
    BMJ Case Rep 2017 May 31;2017. Epub 2017 May 31.
    Department of Endocrine Surgery, Madras Medical College, Chennai, Tamilnadu, India.
    A 49-year-old man presented in the emergency department with altered sensorium and renal failure and was placed on a ventilator. Evaluation with MRI of the brain showed enhancing lesion in the occipital lobe. Biochemical tests revealed elevated calcium and parathyroid hormone (PTH) levels. Read More

    Comparison of the prognostic values of selected inflammation based scores in patients with medullary thyroid carcinoma: A pilot study.
    J Surg Oncol 2017 May 29. Epub 2017 May 29.
    Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.
    Background: The significance of inflammation based scores including the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and plasma fibrinogen remains unclear in medullary thyroid carcinoma (MTC). We aimed to compare the prognostic value of these scores.

    Methods: Seventy-eight patients newly diagnosed as MTC with operation in our institution from May 2009 to September 2016 were retrospectively evaluated. Read More

    Extensive Visceral Calcification Demonstrated on (99m)Tc-MDP Bone Scan in Patient with Carcinoma Penis and Hypercalcemia of Malignancy.
    Indian J Nucl Med 2017 Apr-Jun;32(2):150-152
    Department of Radio-Diagnosis, Infocus Diagnostics, Ahmedabad, Gujarat, India.
    Hypercalcemia is a common life-threatening complication associated with several malignancies. Parathyroid-related peptide has been shown to cause hypercalcemia in several solid tumors but rarely in penile cancer. We report a case of penile cancer with hypercalcemia causing metastatic visceral calcification in lungs, liver, and stomach detected on bone scan without significant abnormalities on CT scan. Read More

    Effectiveness of Intraoperative Parathyroid Monitoring (ioPTH) in predicting a multiglandular or malignant parathyroid disease.
    Int J Surg 2017 May;41 Suppl 1:S26-S33
    Division of General Surgery, Department of Medical, Surgical and Health Sciences, Cattinara Teaching Hospital, Strada di Fiume, 34149, Trieste, Italy. Electronic address:
    Aim: The main goal of our study was to confirm the usefulness of intra-operative parathyroid hormone (PTH) monitoring (ioPTH) when using minimally invasive techniques for treatment of sporadic Primary hyperparathyroidism (pHTP). Furthermore, we aimed to evaluate if ioPTH monitoring may help to predict the etiology of primary hyperparathyroidism, especially in malignant or multiglandular parathyroid disease.

    Methods: A retrospective review of 125 consecutive patients with pHPT who underwent parathyroidectomy between 2001 and 2016 at the Department of General Surgery was performed. Read More

    Giant parathyroid adenoma: differential aspects compared to parathyroid carcinoma.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 May 6.
    Endocrinology and Nutrition DepartmentHospital Puerta de Hierro, Majadahonda, MadridSpain.
    The 85% of cases of primary hyperparathyroidism (PHPT) are due to parathyroid adenomas (PA) and less than 1% to parathyroid carcinomas (PC). The PA usually measure <2 cm, weigh <1 g and generate a mild PHPT, whereas the PC usually exceeds these dimensions and are associated with a severe PHPT. However, giant PA (GPA), which is defined as those larger than 3 g, has been documented. Read More

    Efficacy of Superselective Neck Dissection in Detecting Metastasis in Patients with cN0 Papillary Thyroid Carcinoma at High Risk of Lateral Neck Metastasis.
    Med Sci Monit 2017 May 4;23:2118-2126. Epub 2017 May 4.
    Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Science (CAMS), Peking Union Medical College (PUMC), Beijing, China (mainland).
    Background Material and Methods Results Conclusions. Read More

    Next-generation sequencing for endocrine cancers: Recent advances and challenges.
    Tumour Biol 2017 May;39(5):1010428317698376
    1 Department of Biosciences, Mangalore University, Mangalore, India.
    Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Read More

    Diagnosis and treatment challenges of parathyroid carcinoma in a 27-year-old woman with multiple lung metastases.
    Endocrinol Diabetes Metab Case Rep 2017 13;2017. Epub 2017 Mar 13.
    Endocrinology Research CentreMoscowRussia.
    Summary: Parathyroid carcinoma is an extremely rare disorder with little treatment options. It could be misdiagnosed in medical centers with little experience in management of such cases. Our clinical case shows that the initial misdiagnosis of a parathyroid carcinoma in a young woman has led to the development of multiple lung metastases, thus making its treatment hardly possible. Read More

    Surgical approaches in hereditary endocrine tumors.
    Updates Surg 2017 Apr 28. Epub 2017 Apr 28.
    Minimally Invasive Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
    Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. Read More

    Concomitant thyroid cancer in patients with primary hyperparathyroidism in an endemic goitre region.
    Ann Ital Chir 2017 ;88:15-19
    Objective: Primary hyperparathyroidism (pHPT) is often accompanied by underlying thyroid pathology and 1 to 36% of these thyroid pathologies are malignant. How the identification of these lesions affects patient management is unclear. We present a single-center experience with the prevalence of concomitant thyroid cancer in patients who underwent parathyroidectomy for pHPT. Read More

    Persistent and recurrent hyperparathyroidism.
    Updates Surg 2017 Apr 22. Epub 2017 Apr 22.
    Department of Endocrine Surgery, La Conception Hospital, Assistance Publique Hopitaux de Marseille, 147 BD Baille, 13005, Marseille, France.
    Despite remarkable progress in imaging modalities and surgical management, persistence or recurrence of primary hyperparathyroidism (PHPT) still occurs in 2.5-5% of cases of PHPT. The aim of this review is to expose the management of persistent and recurrent hyperparathyroidism. Read More

    Prognostic Scoring System to Risk Stratify Parathyroid Carcinoma.
    J Am Coll Surg 2017 Mar 15. Epub 2017 Mar 15.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Background: Parathyroid carcinoma is a rare endocrine malignancy that lacks an established system for risk categorization. This study evaluated a prognostic scoring system for recurrence-free survival (RFS) of patients with parathyroid carcinoma.

    Study Design: Patients diagnosed and confirmed to have parathyroid carcinoma and who were treated between 1980 and 2016 at The University of Texas MD Anderson Cancer Center were studied retrospectively. Read More

    The many guises of primary hyperparathyroidism: An unchanged scenario.
    J Pak Med Assoc 2017 Apr;67(4):580-585
    Medical Unit-II, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
    Objective: To study the causes, characteristics and outcome of treatment of patients with primary hyperparathyroidism.

    Methods: This retrospective cohort analysis was conducted at the Jinnah Postgraduate Medical Centre, Karachi, and comprised data of patients with primary hyperparathyroidism between 2004 and 2014. . Read More

    Molecular targeted therapies in adrenal, pituitary and parathyroid malignancies.
    Endocr Relat Cancer 2017 Jun 11;24(6):R239-R259. Epub 2017 Apr 11.
    Department of EndocrinologyOxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.
    Tumourigenesis is a relatively common event in endocrine tissues. Currently, specific guidelines have been developed for common malignant endocrine tumours, which also incorporate advances in molecular targeted therapies (MTT), as in thyroid cancer and in gastrointestinal neuroendocrine malignancies. However, there is little information regarding the role and efficacy of MTT in the relatively rare malignant endocrine tumours mainly involving the adrenal medulla, adrenal cortex, pituitary, and parathyroid glands. Read More

    Epigenetic processes in sporadic parathyroid neoplasms.
    Mol Cell Endocrinol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States. Electronic address:
    Parathyroid tumors (PTs) are highly variable in their genetic background. Increasing evidence demonstrates that endocrine diseases can be caused by epigenetic alterations. The present review is focused on epigenetic aberrations related to PTs. Read More

    Principles of ear nose and throat surgery for pregnant women.
    Br J Hosp Med (Lond) 2017 Apr;78(4):206-212
    Consultant, Department of Ear Nose and Throat Surgery, Heartlands Hospital, Birmingham.
    Management of the pregnant surgical patient is challenging. The surgical procedure is usually postponed until the postpartum period, although this may not be possible in emergency situations. This article highlights the optimal management of the pregnant woman requiring ear nose and throat surgery. Read More

    18F-Fluorocholine, 18F-FDG, and 18F-Fluoroethyl Tyrosine PET/CT in Parathyroid Cancer.
    Clin Nucl Med 2017 Jun;42(6):448-450
    From the *Clinical Institute of Nuclear Medicine and Endocrinology, and †Central Radiology Institute, Kepler University Hospital, Med. Campus III, Linz, Austria; ‡Medical Faculty of the University of Erlangen, Germany; and §Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
    We report on a 71-year-old woman presenting with biochemical features indicating recurrent disease in long-term follow-up of left-sided parathyroid carcinoma. She had undergone several surgical procedures including total thyroidectomy, partial resection of the esophageal wall, and curative neck radiation 12 years previously. PET/CT using F-fluorocholine revealed high uptake in local relapse in the lower neck, comparable to F-FDG, whereas only faint uptake was observed with F-fluoroethyl tyrosine. Read More

    Circulating tumor cells and miRNAs as prognostic markers in neuroendocrine neoplasms.
    Endocr Relat Cancer 2017 Jun 7;24(6):R223-R237. Epub 2017 Apr 7.
    IOS & COLEMAN SrlNaples, Italy.
    The prognosis of neuroendocrine neoplasms (NENs) is widely variable and has been shown to associate with several tissue- and blood-based biomarkers in different settings. The identification of prognostic factors predicting NEN outcome is of paramount importance to select the best clinical management for these patients. Prognostic markers have been intensively investigated, also taking advantage of the most modern techniques, in the perspective of personalized medicine and appropriate resource utilization. Read More

    Effects of sample storage and diluents in the reliability of thyroglobulin measurement in the washout of fine needle aspirates.
    Endocrine 2017 Jun 6;56(3):504-508. Epub 2017 Apr 6.
    Division of Endocrinology, Hospital "J.M. Ramos Mejía", Gral. Urquiza 609, Buenos Aires, 1221, Argentina.
    Objective: To evaluate two variables affecting Thyroglobulin stability in the washout of fine needle aspiration biopsies of thyroid nodules and metastatic lymph nodes.

    Materials And Methods: Thyroglobulin stability after storage at -20 °C up to 14 days was studied in washout performed with normal saline solution and further dilutions with normal saline solution from five metastatic thyroid nodes and six benign thyroid nodules. We also studied thyroglobulin stability in diluents compared with normal saline solution: 4% bovine serum albumin in normal saline solution and diluents free from thyroglobulin or Calcitonin or parathyroid hormone in paired and simultaneous thyroglobulin measurements of washout dilutions from 5/6 benign thyroid nodules and 2/5 metastatic lymph nodes. Read More

    RSK activation via ERK modulates human colon cancer cells response to PTHrP.
    J Mol Endocrinol 2017 Jul 6;59(1):13-27. Epub 2017 Apr 6.
    Departamento de BiologíaBioquímica y Farmacia, INBIOSUR, Universidad Nacional del Sur (UNS) - CONICET, Bahía Blanca, Argentina
    Parathyroid hormone-related peptide (PTHrP) is associated with several human cancers such as colon carcinoma. This disease is a complex multistep process that involves enhanced cell cycle progression and migration. Recently we obtained evidence that in the human colorectal adenocarcinoma Caco2 cells, exogenous PTHrP increases the proliferation and positively modulates cell cycle progression via ERK1/2, p38 MAPK and PI3K. Read More

    Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism.
    Int J Surg Pathol 2017 Apr 1:1066896917701577. Epub 2017 Apr 1.
    1 Mount Sinai Medical Center, Miami Beach, FL, USA.
    Water clear cell adenoma of the parathyroid gland is a rare neoplasm composed of large clear cells with foamy cytoplasm and mild nuclear pleomorphism, compressing the residual nonneoplastic parathyroid tissue. The differential diagnosis includes a variety of neoplasms with clear cell features. In this article, we provide an overview of the entity with a historical perspective, in order to help pathologists in distinguishing it from other neoplasms in their daily practice. Read More

    Staged Surgery for Advanced Thyroid Cancers: Safety and Oncologic Outcomes of Neural Monitored Surgery.
    Otolaryngol Head Neck Surg 2017 May 4;156(5):816-821. Epub 2017 Apr 4.
    1 Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary & Harvard Medical School, Boston, Massachusetts, USA.
    Objective Thyroidectomy with extensive multicompartment bilateral neck dissections for advanced-stage thyroid cancer may lead to increased risk of complications, including bilateral recurrent laryngeal nerve (RLN) paralysis and hypoparathyroidism. A planned staged approach derived from a detailed preoperative radiographic map is associated with a low complication profile. This study evaluates oncologic results and safety of neural monitored, staged thyroid cancer surgery for management of advanced thyroid cancer. Read More

    Less is more: time to expand the indications for minimally invasive video-assisted parathyroidectomy.
    J Endocrinol Invest 2017 Apr 3. Epub 2017 Apr 3.
    Division of Endocrine Surgery, Department of Surgical Pathology, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.
    Purpose: Minimally invasive video-assisted parathyroidectomy (MIVAP) is one of the most widespread targeted parathyroid surgeries for primary hyperparathyroidism (PHP). The aim of this study was to assess its limits and propose an expansion of its indications in the management of parathyroid pathology.

    Methods: A retrospective analysis of 77 consecutive patients who underwent MIVAP for PHP between Jan and Oct 2016 was conducted. Read More

    A nationwide study on parathyroid carcinoma.
    Acta Oncol 2017 Jul 31;56(7):991-1003. Epub 2017 Mar 31.
    a The Division of Endocrinology , Abdominal Center, University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
    Background: Parathyroid carcinoma (PC) is rare and diagnostically challenging. Reported outcomes are rather poor and the incidence might be increasing.

    Material And Methods: We performed a nationwide study on all cases (n= 32) diagnosed in 2000-2011 in Finland, and compared clinical and histopathological characteristics and outcome to atypical parathyroid (APA; n= 28) and parathyroid adenomas (PA; n= 72). Read More

    Apoptosis in Primary Hyperparathyroidism.
    J Invest Surg 2017 Mar 31:1-5. Epub 2017 Mar 31.
    a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
    Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. Read More

    Genomic profiling reveals mutational landscape in parathyroid carcinomas.
    JCI Insight 2017 Mar 23;2(6):e92061. Epub 2017 Mar 23.
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Parathyroid carcinoma (PC) is an extremely rare malignancy lacking effective therapeutic intervention. We generated and analyzed whole-exome sequencing data from 17 patients to identify somatic and germline genetic alterations. A panel of selected genes was sequenced in a 7-tumor expansion cohort. Read More

    Incidental metastatic mediastinal atypical carcinoid in a patient with parathyroid adenoma: a case report.
    J Med Case Rep 2017 Mar 26;11(1):81. Epub 2017 Mar 26.
    Department of Ear, Nose & Throat, Aga Khan University Hospital, Stadium Road, Karachi, Pakistan.
    Background: Atypical carcinoid arising from the mediastinal tissue is a rare neuroendocrine tumor and an association with parathyroid adenoma is very unusual. We report an unusual case of atypical carcinoid of mediastinum with metastasis in a patient presenting with parathyroid adenoma, which is the first case to be reported from Pakistan.

    Case Presentation: A 51-year-old Pakistani man was seen in postoperative intensive care after right parathyroidectomy and mediastinal mass resection for the management of postoperative hypocalcaemia. Read More

    Lung carcinoma progression and survival versus amino- and carboxyl-parathyroid hormone-related protein expression.
    J Cancer Res Clin Oncol 2017 Mar 25. Epub 2017 Mar 25.
    Pathology Service, VA San Diego Healthcare System, San Diego, USA.
    Purpose: Expression of the carboxyl PTHrP region of parathyroid hormone-related protein (PTHrP) is a positive prognostic indicator in women with lung cancer, but amino PTHrP is a negative indicator in other lung cancer patients. This project investigated whether PTHrP could be expressed as predominantly amino PTHrP or carboxyl PTHrP in individual lung carcinomas. It also assessed domain-specific effects on cancer progression and patient survival. Read More

    [Parathyroid cancer].
    Vnitr Lek 2017 ;63(2):139-144
    Parathyroid cancer is a rare endocrine malignancy, representing less than 1 % of all cases of primary hyperparathyroidism. The exact etiology of the disease remains unknown. Known risk factors include neck irradiation, end stage renal failure, genetic factors, particularly the the HPRT2/CDCT73 gene mutation. Read More

    Malignant hypercalcaemia related to parathyroid hormone-related peptide (PTHrP) secretion from a metastatic pancreatic neuroendocrine tumour (NET).
    BMJ Case Rep 2017 Mar 22;2017. Epub 2017 Mar 22.
    The ARDEN NET Centre, ENETS CoE, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
    A 54-year-old woman presented to our centre with acute abdominal pain and vomiting. Routine blood tests showed severe hypercalcaemia (>4 mmol/L). Serum parathyroid hormone (PTH) was suppressed. Read More

    Unintentional parathyroidectomy during total thyroidectomy surgery: A single surgeon's experience.
    Medicine (Baltimore) 2017 Mar;96(11):e6411
    aDepartment of Head Neck, First Affiliated Hospital of Zhengzhou University bDepartment of Head Neck and Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, PR China.
    In this study, we investigated incidental parathyroidectomy during total thyroidectomy surgery that required central lymph node dissection and the potential risk factors. Patients requiring total thyroidectomy and tracheoesophageal groove node dissection were enrolled in the study from January 2013 to June 2015 and we obtained all medical information, including pathology reports. Furthermore, we recorded the parathyroid hormone level in all patients prior to operation and then 3 further times: 1 day, 1 week, and 3 months after surgery. Read More

    Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.
    Oncogene 2017 Mar 13. Epub 2017 Mar 13.
    Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.
    The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malignant neoplasms. HPT-JT is caused by mutations of the cell division cycle 73 (CDC73) gene, located on chromosome 1q31.2 and encodes a 531 amino acid protein, parafibromin. Read More

    Preoperative ultrasound-guided carbon nanoparticles localization for metastatic lymph nodes in papillary thyroid carcinoma during reoperation: A retrospective cohort study.
    Medicine (Baltimore) 2017 Mar;96(10):e6285
    aDepartment of Thyroid & Parathyroid Surgery bDepartment of Ultrasound, West China Hospital cWest China School of Stomotology, Sichuan University, Chengdu, PR China.
    Due to the damaged anatomical structure and a large amount of fibrous and scar tissues in the surgical field, reoperation of papillary thyroid carcinoma is difficult. This study introduces a new method of locating metastatic lymph nodes during reoperation and evaluates the effectiveness and safety of the preoperative ultrasound-guided carbon nanoparticles (CNs) localization. This retrospective cohort study enrolled 52 patients who were diagnosed with lymph node metastasis by histopathology and underwent reoperation from October 2015 to February 2016. Read More

    Preoperative predictors of lateral neck lymph node metastasis in papillary thyroid microcarcinoma.
    Medicine (Baltimore) 2017 Mar;96(10):e6240
    aThyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zheng Zhou bThyroid and Parathyroid Center, West China Hospital of Sichuan University, Chengdu, China.
    Lateral lymph node metastasis (LNM) is not uncommon in papillary thyroid microcarcinoma (PTMC). Our present study aimed to investigate the risk factors associated with lateral LNM in PTMC.We retrospectively collected data pertaining to 366 patients with PTMC who underwent surgery at our center from 2010 to 2015. Read More

    Mapping the distribution of nodal metastases in papillary thyroid carcinoma: Where exactly are the nodes?
    Laryngoscope 2017 Mar 8. Epub 2017 Mar 8.
    Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.
    Objective: To characterize nodal disease of patients presenting with papillary thyroid carcinoma (PTC) STUDY DESIGN: Retrospective chart review.

    Methods: PTC patients who underwent thyroidectomy and/or neck dissection (revision/primary) from 2004 to 2009 at a tertiary-care hospital were reviewed. Preoperative computed tomography (CT) scan and ultrasonography were utilized to identify macroscopic, clinically apparent nodal metastasis (cN+). Read More

    A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.
    BMC Gastroenterol 2017 Mar 7;17(1):37. Epub 2017 Mar 7.
    Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
    Background: In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. Treatment for his esophageal stricture and ZES was discussed. Read More

    Parathyroid Adenomas in Adults and Adolescents. Critical Appraisal and Surgical Strategy in 18 Cases.
    Chirurgia (Bucur) 2017 Jan-Feb;112(1):18-24
    Background: Our study underline scarcity of isolated case reports or small case series of parathyroid adenoma (PA) published in autochthonous medical literature,their variable clinical expression among the "historic" varieties but also the diagnostic difficulties and delays of diagnosis as well consecration of surgery as the golden therapeutic standard of this disorder.

    Patients And Method: Demographic, clinical presentations, laboratory and imaging data, operative findings and procedures together with pathology account and outcome from the case reports of 18 patients with documented PHP were retrospectively analyzed. Results: The male/female ratio was 1/5, with ages ranging from 16 to 58 (mean 46) years. Read More

    Skip lateral lymph node metastasis leaping over the central neck compartment in papillary thyroid carcinoma.
    Oncotarget 2017 Apr;8(16):27022-27033
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu 610041, China.
    Objective: This study was performed to investigate the frequency and pattern as well as the predictive factors of skip metastasis (lateral cervical lymph node metastasis without central lymph node metastasis) in papillary thyroid carcinoma (PTC).

    Methods: 450 PTC patients who received total thyroidectomy with central neck dissection(CND) combined with modified radical lateral neck dissection(LND) were divided into two groups: with or without skip metastases. The clinicopathological characteristics were statistically compared and analyzed, and univariate and multivariate analyses were performed to detect the risk factors of skip metastasis. Read More

    Fine needle cytology pre-surgical differentiation of parathyroid neoplasms: Is it reliable?
    Cytopathology 2017 Feb 20. Epub 2017 Feb 20.
    Azienda Ospedaliera Universitaria "San Giovanni di Dio e Ruggi d' Aragona", Salerno, Italy.
    Background: Fine needle cytology (FNC) of a parathyroid neoplasia (PN) is reliable, but needs to be confirmed by Parathormone (PTH) and Thyroglobulin (TG) immunoassay on needle washing or by immunocytochemistry (ICC) evaluation. The differentiation between parathyroid adenoma (PA), atypical adenoma (PAA) and carcinoma (PC) is difficult on histology or even impossible on FNC. The aim of this study was to evaluate possible cytological criteria to classify FNC-PN further. Read More

    Synchronous papillary thyroid carcinoma and breast ductal carcinoma: A rare case report and literature review.
    Medicine (Baltimore) 2017 Feb;96(7):e6114
    aDepartment of Pathology, West China Hospital of Sichuan University bThyroid and Parathyroid Surgery Group, West China Hospital of Sichuan University, Chengdu 610041, China.
    Background: The incidences of both thyroid cancer and breast cancer have been rising in recent years; however, it is very rare to find a single person with both of these cancers. Only a few cases of synchronous thyroid and breast cancer have been published, and even fewer cases have been reported in older patients (>60 years).

    Case Summary: The current study presents a case of synchronous papillary thyroid carcinoma and breast ductal carcinoma in an elderly patient. Read More

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