12,894 results match your criteria Parathyroid Carcinoma


Commentary: Next-Generation Sequence Analysis of Parathyroid Carcinoma.

J Endocr Soc 2019 Mar 22;3(3):560-562. Epub 2018 Oct 22.

Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut School of Dental Medicine, Farmington, Connecticut.

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http://dx.doi.org/10.1210/js.2018-00315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378759PMC

A review of parathyroid mass and patients with nonspecific complaints.

J Int Med Res 2019 Feb 21:300060519827169. Epub 2019 Feb 21.

Department of Internal Medicine, Amasya University Research and Education Hospital, Amasya, Turkey.

In this review, parathyroid mass and its nonspecific symptoms are discussed. In daily clinical practice, patients present with varying symptoms, including depression, chest pain, pancreatitis, or nonspecific fatigue. If the patient is not tested for a parathyroid mass along with performing routine electrolyte tests, diagnosing such a patient with a parathyroid mass may take several years. Read More

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http://dx.doi.org/10.1177/0300060519827169DOI Listing
February 2019

Comprehensive Genomic Characterization of Parathyroid Cancer Identifies Novel Candidate Driver Mutations and Core Pathways.

J Endocr Soc 2019 Mar 3;3(3):544-559. Epub 2018 Sep 3.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Context: Elucidating the genomic landscape of sporadic parathyroid carcinoma (PC) has been limited by low tumor incidence.

Objective: Identify driver mutations of sporadic PC and potential actionable pathways.

Methods: Patients undergoing surgical resection for sporadic PC between 1980 and 2016 at MD Anderson Cancer Center were identified. Read More

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http://dx.doi.org/10.1210/js.2018-00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372985PMC

Parathyroid Carcinoma and Persistent Hypercalcemia: A Case Report and Review of Therapeutic Options.

Saudi J Med Med Sci 2018 May-Aug;6(2):115-118. Epub 2018 Apr 16.

Department of Endocrinology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Parathyroid carcinomas are very uncommon, accounting for 0.1% to 5% of all causes of primary hyperparathyroidism. Parathyroid-jaw tumor syndrome, with a mutation in that encodes parafibromin, is the most common genetic association. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_104_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196698PMC

Robotic transoral thyroidectomy: Total thyroidectomy and ipsilateral central neck dissection with da Vinci Xi Surgical System.

Head Neck 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Background: Transoral approach for thyroidectomy draws attention recently among the thyroid surgeons, with the merits of cosmetic outcomes and minimal flap dissection. The aim of this study is to demonstrate the details and the steps of transoral robotic thyroidectomy.

Methods: We made three incisions in the gingival-buccal sulcus for three 8-mm intraoral ports: one inverted U-shaped 1-cm midline incision approximately 2 cm above the frenulum, and two 0. Read More

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http://dx.doi.org/10.1002/hed.25661DOI Listing
February 2019

Parathyroid adenoma with prominent lymphocytic infiltrate having histological features highly suggestive of IgG4-related disease: a case report and literature review.

Endocr J 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Parathyroid adenoma with prominent lymphocytic infiltrate is a rare disease. Until now, 11 patients have been reported. Herein, we report a 57-year-old man who had a neck mass that was incidentally found. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0428DOI Listing
February 2019
1 Read

Neck Dissection in the Surgical Treatment of Thyroid Cancer.

Endocrinol Metab Clin North Am 2019 03 26;48(1):143-151. Epub 2018 Dec 26.

Otolaryngology Department, Augusta University, Thyroid and Parathyroid Center, 1120 Fifteenth Street, BP-4109, Augusta, GA 30912-4060, USA. Electronic address:

The incidence of thyroid cancer is increasing, largely attributable to overdetection related to prevalent diagnostic and radiologic imaging modalities. Papillary thyroid cancer remains the most common thyroid malignancy. It has a high tendency for regional metastasis to the cervical lymph nodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898529183059
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http://dx.doi.org/10.1016/j.ecl.2018.11.004DOI Listing
March 2019
3 Reads

[Application of carbon nano-particles in total thyroidectomy combined with lymphadenectomy in area Ⅵ].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):28-32

Department of Head and Neck Surgery, the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.

To evaluate the effects of staining with carbon nanoparticles on the identification of parathyroid glands and lymph nodes during thyroid carcinoma surgery combined with lymphadenectomy. A total of 194 patients with papillary thyroid carcinoma who underwent thyroidectomy combined with lymphadenectomy from April 2016 to January 2018 were reviewed. Of them 104 cases were injected with carbon nanoparticles in operation area (nanocarbon group) and other 90 cases without the injection of carbon nanoparticles were as control group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.007DOI Listing
January 2019

Diagnostic pitfalls in a cystic ectopic intrathyroidal parathyroid adenoma mimicking a nodular goiter: A care-compliant case report.

Medicine (Baltimore) 2019 Feb;98(5):e14351

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Cystic parathyroid adenomas are rare and seldom arise in ectopically located glands which may be found within the carotid sheath, mediastinum, thymus, or thyroid grand. They cannot be detected consistently by any imaging methods. Unusual symptoms may bring about certain pitfalls and difficulties for the diagnosis of primary hyperparathyroidism (PHPT) caused by cystic parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014351DOI Listing
February 2019
2 Reads

Parathyroid adenoma presenting with spontaneous cervical and anterior mediastinal hemorrhage: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14347

Department of Surgery, Division of Surgical Oncology.

Rationale: Spontaneous anterior cervical or mediastinal hemorrhage is a rare presentation of parathyroid adenoma.

Patient Concerns: A 69-year-old woman presented with neck hematoma and dysphagia and was found to have a soft tissue mass adjacent to her thyroid gland as seen on MRI and neck ultrasound.

Diagnosis: Laboratory testing demonstrated elevated calcium and parathyroid hormone supporting diagnosis of parathyroid adenoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000014347DOI Listing
February 2019
1 Read

The role of combined techniques of scintigraphy and SPECT/CT in the diagnosis of primary hyperparathyroidism: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14154

"Lucian Blaga" University of Sibiu, Romania.

Rationale: Primary hyperparathyroidism, usually as a result of a hyperfunctioning parathyroid gland, represents more than 90% cases of patients evaluated for hypercalcemia. Combined techniques of preoperative scintigraphy and SPECT/CT serve as a successful minimally-invasive parathyroidectomy. This recent imaging method provides four-dimensional functional images with advanced contrast resolution which greatly facilitates preoperative localization of parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358356PMC
January 2019
1 Read

Perioperative characteristics, histological diagnosis, and outcome in cats undergoing surgical treatment of primary hyperparathyroidism.

Vet Surg 2019 Jan 21. Epub 2019 Jan 21.

VCA Canada-404 Veterinary Emergency and Referral, Newmarket, Ontario, Canada.

Objective: To report perioperative characteristics, complications, histopathologic diagnosis and outcome in cats undergoing surgical treatment for primary hyperparathyroidism (PHPT).

Study Design: Multi-institutional, retrospective case series.

Animals: Thirty-two client-owned cats. Read More

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http://dx.doi.org/10.1111/vsu.13165DOI Listing
January 2019
3 Reads
1.041 Impact Factor

The role of ultrasound in the diagnosis of the coexistence of primary hyperparathyroidism and non-medullary thyroid carcinoma.

BMC Med Imaging 2019 01 18;19(1). Epub 2019 Jan 18.

Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, 200233, China.

Background: The coexistence of primary hyperparathyroidism(PHPT) and papillary thyroid cancer(PTC) is a known entity; it is a rare and complicated setting for diagnostic imaging.

Methods: After reviewing clinical data of 112 patients who had been treated for PHPT in our facility between January 2015 and December 2017, we identified 7 non-medullary thyroid carcinoma (NMTC) (6.25%). Read More

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http://dx.doi.org/10.1186/s12880-019-0306-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339388PMC
January 2019
3 Reads
0.983 Impact Factor

Parathyroid Carcinoma.

Front Horm Res 2019 19;51:63-76. Epub 2018 Nov 19.

Parathyroid carcinoma (PC) is a rare endocrine malignancy, accounting for <1% of all cases of sporadic primary hyperparathyroidism (PHPT) and up to 15% in the hereditary hyperparathyroidism-jaw tumor syndrome. Genomic alterations identified in PC are mostly represented by CDC73 gene mutations, codifying for a loss-of-function protein termed parafibromin. Whole exome sequencing identified mutations in other genes, such as mTOR, KMT2D, CDKN2C, THRAP3, PIK3CA, and EZH2 genes, CCND1 gene amplification. Read More

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http://dx.doi.org/10.1159/000491039DOI Listing
November 2018
2 Reads

Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

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https://www.karger.com/Article/FullText/491037
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http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
3 Reads

Primary Hyperparathyroidism.

Authors:
Laura Masi

Front Horm Res 2019 19;51:1-12. Epub 2018 Nov 19.

The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. Read More

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https://www.karger.com/Article/FullText/491034
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http://dx.doi.org/10.1159/000491034DOI Listing
November 2018
2 Reads

Can preoperative vitamin D deficiency predict postoperative hypoparathyroidism following thyroid surgery?

Langenbecks Arch Surg 2019 Jan 14. Epub 2019 Jan 14.

Department of Endocrine Surgery, Catholic Hospital Mainz, An der Goldgrube 11, 55131, Mainz, Germany.

Importance: Postoperative hypoparathyroidism remains a relevant problem after thyroid surgery. Although the roles of vitamin D deficiency and other risk factors have been discussed in previous studies, variable results have been reported.

Objective: Predicting the risk of postoperative hypocalcemia could be helpful for individual prognoses and medical treatment. Read More

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http://dx.doi.org/10.1007/s00423-019-01748-3DOI Listing
January 2019
1 Read

MRI findings and utility of DWI in the evaluation of solid parathyroid lesions.

Radiol Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Radiology, Bezmialem Vakif University, Istanbul, Turkey.

Purpose: To evaluate the MRI findings of solid parathyroid lesions and to elaborate on a possible improvement of MRI detection of parathyroid lesions by the use of additional DWI.

Materials And Methods: MRI and DWI properties of pathologically proven 20 solid parathyroid lesions were retrospectively reviewed. Mean ADC values (b50 + b400 + b800/3) of parathyroid lesions were compared with that of normal appearing thyroid parenchyma (TP), sternocleidomastoid muscle (SCM) and jugulodigastric lymph nodes (JDLN). Read More

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http://link.springer.com/10.1007/s11547-018-0970-8
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http://dx.doi.org/10.1007/s11547-018-0970-8DOI Listing
January 2019
2 Reads

Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review.

J Breast Cancer 2018 Dec 27;21(4):463-467. Epub 2018 Nov 27.

Department of Medical Oncology, Limoges University Hospital, Limoges, France.

Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. Read More

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http://dx.doi.org/10.4048/jbc.2018.21.e55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310724PMC
December 2018
1 Read

Coexistence of a large functioning parathyroid cyst with papillary thyroid carcinoma: A case report and review of the literature.

Case Rep Womens Health 2019 Jan 30;21:e00091. Epub 2018 Nov 30.

Department of Endocrinology and Diabetes, Hippokration Hospital of Thessaloniki, Thessaloniki, Greece.

Parathyroid cysts constitute a rare cause of primary hyperparathyroidism (PHPT). PHPT may also rarely coexist with non-medullary thyroid carcinoma (NMTC). We describe a case of a 70-year-old woman who was diagnosed with PHPT, on the occasion of nephrolithiasis (corrected calcium and PTH levels: 10. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22149112183014
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http://dx.doi.org/10.1016/j.crwh.2018.e00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305791PMC
January 2019
4 Reads

An Unusual Case of Medullary Thyroid Carcinoma and A Revision of Current Literature.

Endocr Metab Immune Disord Drug Targets 2019 ;19(2):226-229

Endocrinology and Metabolism Unit, University-Hospital "Santa Maria della Misericordia", Udine, Italy.

Background: Medullary thyroid cancer (MTC) accounts for 5% of all thyroid cancers and occurs either sporadically or in a hereditary pattern. Routine calcitonin (CT) measurement is suggested for MTC screening in patients with nodular thyroid disease.

Patient Findings: A 45 years-old woman incidentally discovered, with neck ultrasound, the presence of thyroid micronodules. Read More

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http://dx.doi.org/10.2174/1871530319666181220165350DOI Listing
January 2019
3 Reads

Cyclin-dependent kinase 7 is a potential therapeutic target in papillary thyroid carcinoma.

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6):1361-1368

Department of Thyroid and Parathyroid Surgery Center, Sichuan University West China Hospital, China.

Given the pathological incidence of metastases or radioiodine-refractory papillary thyroid carcinoma (PTC) is increasing worldwide, patients have little alternatives when choosing effective drugs. Therefore, it is necessary to develop new therapeutic targets for PTC treatment. CDK7 is a member of the cyclindependent protein kinase (CDK) family, which plays an important role in various types of cancers. Read More

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December 2018
1 Read

[Unusual mode of revelation of primary hyperparathyroidism in young subjects: about two cases].

Pan Afr Med J 2018 26;30:232. Epub 2018 Jul 26.

Service d'Endocrinologie, Diabétologie CHU Hédi Chaker Sfax, Tunisie.

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http://dx.doi.org/10.11604/pamj.2018.30.232.12779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295291PMC
January 2019
3 Reads

Previously unreported deletion of CDC73 involving exons 1-13 was detected in a patient with recurrent parathyroid carcinoma.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Internal Medicine, Woodhull Medical Center, Brooklyn, New York, USA.

Parathyroid carcinoma (PC) is a rare malignancy, presenting sporadically or as part of a genetic syndrome. Diagnosis of PC includes the histopathological diagnosis based on capsular, perineural, or vascular invasion or metastasis. High suspicion for malignancy includes hypercalcaemia greater than 14 mg/dL, extremely high serum parathyroid hormone (PTH) levels, as well as large masses. Read More

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http://dx.doi.org/10.1136/bcr-2018-225784DOI Listing
November 2018
1 Read

Incidental Detection of Plasma Cell Neoplasm on 18F-Choline PET/CT Imaging.

Clin Nucl Med 2019 Feb;44(2):140-141

From the Departments of Nuclear Medicine, and.

F-Fluorocholine is a relatively new, extremely versatile radiotracer for detecting proliferative or mitogenic activity. Its diagnostic potential has been explored in cancers of the prostate, liver, esophagus, breast, brain, and lung, as well as lymphoma, sarcoma, melanoma, and parathyroid adenomas. The authors present a case where fluorocholine PET/CT performed for characterizing a space-occupying lesion in the brain revealed intensely tracer-avid skull lesions with intracranial soft tissue component and multiple other skeletal lesions. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9731
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http://dx.doi.org/10.1097/RLU.0000000000002415DOI Listing
February 2019
7 Reads

Benign call rate and molecular test result distribution of ThyroSeq v3.

Cancer Cytopathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pathology, University of Pittsburgh Medical Center-Presbyterian, Pittsburgh, Pennsylvania.

Background: The benign call rate (BCR) is the percentage of cytomorphologically indeterminate cases with subsequent benign or negative molecular results. For rule-out tests, the BCR is an important parameter because these molecular "negative" cases may be managed similarly to those with a benign cytology diagnosis. Although earlier versions of ThyroSeq molecular tests were less effective in excluding malignancy, the extensively expanded v3 version with a high negative predictive value is considered to represent a rule-out test. Read More

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http://doi.wiley.com/10.1002/cncy.22088
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http://dx.doi.org/10.1002/cncy.22088DOI Listing
December 2018
9 Reads

A Successful Tracheal Resection and Anastomosis in Papillary Thyroid Carcinoma with Tracheal Invasion.

Open Access Maced J Med Sci 2018 Nov 23;6(11):2161-2164. Epub 2018 Nov 23.

Surgical Oncology Division, Department of Surgery, Faculty of Medicine Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia.

Background: Well-differentiated thyroid carcinoma (DTC) can be locally aggressive, invading aerodigestive tract. The rationale for aggressive surgical resection in this clinical setting is supported by a long-term local control with a positive impact on survival.

Case Report: A 60-year-old male patient was consulted by a digestive surgeon of unaware thyroid enlargement. Read More

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http://dx.doi.org/10.3889/oamjms.2018.438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290409PMC
November 2018
1 Read

Parathyroid carcinoma.

Best Pract Res Clin Endocrinol Metab 2018 Dec 1;32(6):877-889. Epub 2018 Dec 1.

Departments of Laboratory Medicine and Pathobiology, Medicine and Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Parathyroid carcinoma (PC) is a rare disease with an indolent behavior due to the low malignant potential. The etiology is unknown. Somatic mutations of CDC73 gene, the same gene involved in the hyperparathyroidism-jaw tumor syndrome, can be identified in up to 70% of patients with PC and in one-third of cases the mutations are germline. Read More

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http://dx.doi.org/10.1016/j.beem.2018.11.002DOI Listing
December 2018
1 Read

[Parathyroid carcinoma: diagnosis by a femur fracture].

Acta Ortop Mex 2018 Jul-Aug;32(4):229-233

Departamento de Anatomopatología del Hospital Ángeles León. León, Guanajuato. México.

Background: Carcinoma of the parathyroid gland (PC) described by De Quervain since 1909, it represents the least common neoplasm, with an incidence of 1,25/10,000,000 peoples. It has been reported approximately 1,000 cases of CP in world literature. There are two series in Mexico, one of eight patients and other with four cases. Read More

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December 2018
8 Reads

A new classification of parathyroid glands to evaluate in situ preservation or autotransplantation during thyroid surgery.

Medicine (Baltimore) 2018 Nov;97(48):e13231

Department of Thyroid Surgery,West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

The indication for autotransplantation of parathyroid glands is still controversial. A new classification of parathyroid glands based on the positional relationship among parathyroid glands, thyroid gland and thymus was created to decide in situ preservation or autotransplantation during thyroid surgery.A retrospective study included patients with papillary thyroid cancer who underwent total thyroidectomy with bilateral central lymph node dissection between November 2014 and November 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000013231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283141PMC
November 2018
1 Read

Molecular pathogenesis of parathyroid tumours.

Best Pract Res Clin Endocrinol Metab 2018 Dec 20;32(6):891-908. Epub 2018 Nov 20.

Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, Division of Medical Genetics, Italy. Electronic address:

Parathyroid tumors represent an elusive endocrine neoplasia, which lead to primary hyperparathyroidism, pHPT, a common endocrine calcium disorder characterized by hypercalcemia and normal-high parathormone secretion. Parathyroid tumours are benign adenomas or multiple glands hyperplasia in the vast majority (>99% of cases), while malignant neoplasms are rare (less than 1%). Despite pHPT is a common disorder, our knowledge about the genetic predisposition and molecular pathophysiology is limited to the familial syndromic forms of parathyroid tumour, that, however, represent not more than the 10% of all the cases; instead, the pathophysiology of sporadic forms remains an open field, although data about epigenetic mechanisms or private genes have been supposed. Read More

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http://dx.doi.org/10.1016/j.beem.2018.11.001DOI Listing
December 2018
3 Reads

Molecular genetic insights into sporadic primary hyperparathyroidism.

Endocr Relat Cancer 2019 Feb;26(2):R53-R72

Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by dysregulation of parathyroid hormone release. The large majority of PHPT cases are attributable to sporadic, single-gland parathyroid adenoma, in which MEN1 and CCND1/cyclin D1 are the most well-established drivers of tumorigenesis. Sporadic parathyroid carcinoma, which appears to mostly arise through molecular pathways distinct from those causing benign parathyroid tumors, is rare and is most frequently driven by mutational inactivation of the CDC73 (HRPT2) tumor suppressor gene. Read More

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http://dx.doi.org/10.1530/ERC-18-0304DOI Listing
February 2019
1 Read

Analysis of the role of thyroidectomy and thymectomy in the surgical treatment of secondary hyperparathyroidism.

Am J Otolaryngol 2019 Jan - Feb;40(1):67-69. Epub 2018 Oct 22.

Division of Head and Neck Surgery, Department of Ophthalmology, Otolaryngology, Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Brazil. Electronic address:

Purpose: Parathyroidectomy can be subtotal or total with an autograft for the treatment of renal hyperparathyroidism. In both cases, it may be extended with bilateral thymectomy and total or partial thyroidectomy. Thymectomy may be recommended in combination with parathyroidectomy in order to prevent mediastinal recurrence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709183075
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http://dx.doi.org/10.1016/j.amjoto.2018.10.010DOI Listing
October 2018
7 Reads

Intrathyroidal Parathyroid Carcinoma: An Atypical Thyroid Lesion.

Front Endocrinol (Lausanne) 2018 1;9:641. Epub 2018 Nov 1.

Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.

Parathyroid carcinoma is a rare endocrine malignancy that is typically difficult to diagnose at presentation. Here, we report a 63 year-old man who had symptomatic hypercalcemia. Investigations revealed a thyroid nodule and a lateral neck mass that was biopsied and diagnosed as "suspicious for a neuroendocrine neoplasm. Read More

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http://dx.doi.org/10.3389/fendo.2018.00641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230986PMC
November 2018
11 Reads

Intraoperative diagnosis of the head and neck lesions, thyroid and parathyroid gland, bone and soft tissue, and genitourinary tract.

Cesk Patol 2018 ;54(2):72-80

In this article, indications and pitfalls in frozen section diagnosis in selected organs and systems are discussed. The main indications for frozen section examination of head and neck and genitourinary system lesions are to evaluate the resection margin and the metastatic involvement of lymph nodes. Recently, intraoperative consultation has been introduced for identification of patients who might benefit from testis-sparing surgery. Read More

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January 2018
6 Reads

Autoinfarction of Giant Parathyroid Adenoma after Preoperative Withdrawal of Anticoagulants.

Case Rep Surg 2018 23;2018:9261749. Epub 2018 Oct 23.

Division of General Surgery, Department of Surgery, University Health Network, Canada.

A 71-year-old man with known history of atrial fibrillation (treated with routine rivaroxaban therapy) was found to have incidental biochemical elevated calcium and parathyroid hormone (PTH) levels. His physical examination demonstrated the presence of a palpable right neck mass. Subsequent imaging studies revealed a large parathyroid mass as well as multiple bone lesions, raising the suspicion of parathyroid carcinoma. Read More

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https://www.hindawi.com/journals/cris/2018/9261749/
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http://dx.doi.org/10.1155/2018/9261749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218753PMC
October 2018
8 Reads

Synchronous Metastatic Breast Carcinoma and Parathyroid Adenoma on 18F-FDG PET/CT and 99mTc-Sestamibi Imaging.

Clin Nucl Med 2019 Feb;44(2):148-149

Department of Radiology, University of Michigan.

In addition to nuclear cardiac and breast imaging, Tc-sestamibi scintigraphy is often used to localize parathyroid adenomas. F- fluorodeoxyglucose (FDG) PET is heavily utilized in oncology, although its use in identifying parathyroid adenomas is limited. We describe a case of a 57-year-old woman who underwent parathyroid scintigraphy and F-FDG PET/CT in the same week due to hyperparathyroidism and an enlarging breast mass, respectively. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002380DOI Listing
February 2019
2 Reads
3.930 Impact Factor

Postoperative swallowing disorder after thyroid and parathyroid resection.

Pragmat Obs Res 2018 16;9:63-68. Epub 2018 Oct 16.

Department of General and Visceral Surgery, Ulm University Medical Center, 89081 Ulm, Germany,

Introduction: Dysphagia is frequently reported after thyroidectomy. Here, we investigated the incidence of postoperative dysphagia after uncomplicated thyroidectomy and parathyroidectomy. Further, we analyzed diagnosis and types of therapy to identify possible patients at risk. Read More

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http://dx.doi.org/10.2147/POR.S172059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198892PMC
October 2018
2 Reads

Profiling analysis of long non-coding RNA and mRNA in parathyroid carcinoma.

Endocr Relat Cancer 2018 Nov 1. Epub 2018 Nov 1.

Y Zhao, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Parathyroid carcinoma (PCa) is a rare endocrine neoplasia that typically has unfavourable outcomes. The contribution of long non-coding RNAs (lncRNAs) to the development of malignant and benign parathyroid tumours remains largely unknown. In this study, we explored transcriptomic profiling of lncRNA and mRNA expression in 6 PCa, 6 parathyroid adenoma (PAd) and 4 normal parathyroid (PaN) tissues. Read More

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https://erc.bioscientifica.com/view/journals/erc/aop/erc-18-
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http://dx.doi.org/10.1530/ERC-18-0480DOI Listing
November 2018
6 Reads

NPS - 2143 (hydrochloride) inhibits melanoma cancer cell proliferation and induces autophagy and apoptosis.

Med Sci (Paris) 2018 Oct 7;34 Focus issue F1:87-93. Epub 2018 Nov 7.

Department of Dermatology, Jinan Central Hospital affiliated to Shandong University, No.105 Jiefang Road, Jinan 250013, Shandong Province, China.

Melanoma is a common and aggressive skin cancer caused by the oncogenic transformation of melanocytes. NPS-2143 (hydrochloride) is a calcification drug that acts as an antagonist of the calcium-sensing receptor (CaSR) and consequently stimulates the release of parathyroid hormone. In the present work, we treated cells from the human melanoma cell line M14 to investigate the effects of NPS-2143 on melanoma cells and elucidate their underlying mechanisms. Read More

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https://www.medecinesciences.org/10.1051/medsci/201834f115
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http://dx.doi.org/10.1051/medsci/201834f115DOI Listing
October 2018
5 Reads

Genomic Profiling of Parathyroid Carcinoma Reveals Genomic Alterations Suggesting Benefit from Therapy.

Oncologist 2018 Oct 29. Epub 2018 Oct 29.

Foundation Medicine Inc., Cambridge, Massachusetts, USA.

Background: Parathyroid carcinoma (PC) is a rare endocrine malignancy that can cause life-threatening hypercalcemia. We queried whether comprehensive genomic profiling (CGP) of PC might identify genomic alterations (GAs), which would suggest benefit from rationally matched therapeutics.

Methods: We performed hybrid-capture-based CGP to identify GAs and tumor mutational burden (TMB) in tumors from patients with this malignancy. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0334DOI Listing
October 2018
10 Reads

Clear Cell Variant of a Follicular Thyroid Tumor With Uncertain Malignant Potential: A Case Report.

Int J Surg Pathol 2018 Oct 29:1066896918809490. Epub 2018 Oct 29.

1 Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.

Follicular neoplasms of the thyroid gland are most often characterized by follicular-patterned thyrocytes with a neutrally stained cytoplasm, while a minority of cases present with oncocytic differentiation (Hürthle cell tumors). Exceedingly rare variants with a clear cell phenotype have also been reported, both as clear cell follicular thyroid adenomas (ccFTAs) and clear cell follicular carcinomas (ccFTCs). We present a patient with a 30-mm lesion in the thyroid isthmus in which the preoperative cytology proposed a follicular tumor. Read More

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http://dx.doi.org/10.1177/1066896918809490DOI Listing
October 2018
17 Reads

Preliminary exploration of potential molecular therapeutic targets in recurrent and metastatic parathyroid carcinomas.

Int J Cancer 2019 Feb 3;144(3):525-532. Epub 2018 Dec 3.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Parathyroid carcinoma (PC) is a rare endocrine malignancy. Surgical resection is curative for local lesions, while effective therapies are lacking for recurrent or metastatic PCs. To study whether targeted therapies could be applied in recurrent or metastatic PCs, potential therapeutic targets were identified with next-generation sequencing (NGS). Read More

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http://doi.wiley.com/10.1002/ijc.31948
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http://dx.doi.org/10.1002/ijc.31948DOI Listing
February 2019
13 Reads

A Young Male with Parafibromin-Deficient Parathyroid Carcinoma Due to a Rare Germline HRPT2/CDC73 Mutation.

Endocr Pathol 2018 Dec;29(4):374-379

Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto and Mount Sinai Hospital, Toronto, ON, M5T 3L9, Canada.

Hyperparathyroidism, commonly observed in asymptomatic middle-aged women, with mild hypercalcemia, is usually caused by a benign adenoma. Some cases present with more severe manifestation and greater hypercalcemia. Within this spectrum, several familial/genetic associations have been discovered. Read More

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http://link.springer.com/10.1007/s12022-018-9552-5
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http://dx.doi.org/10.1007/s12022-018-9552-5DOI Listing
December 2018
13 Reads

Disparity between Preoperative and Pre-Excisional Intraoperative Parathyroid Hormone in Parathyroid Surgery.

Int Arch Otorhinolaryngol 2018 Oct 29;22(4):382-386. Epub 2018 Mar 29.

Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States.

 Intraoperative parathyroid hormone (ioPTH) testing is a widely accepted standard for assessing the parathyroid gland function. A decline of preoperative parathyroid hormone (PTH) levels by more than 50% is one accepted measure of parathyroid surgery adequacy. However, there may be a variation between preoperative PTH levels obtained at a clinic visit and pre-excisional ioPTH. Read More

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http://dx.doi.org/10.1055/s-0038-1635574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197976PMC
October 2018
2 Reads

An Unusual Salivary Gland Tumor Mimicking Papillary Thyroid Carcinoma: Mammary Analog Secretory Carcinoma.

Front Endocrinol (Lausanne) 2018 25;9:555. Epub 2018 Sep 25.

Department of Pathology, University Health Network, Toronto, ON, Canada.

Thyroid tumors usually present as masses in the thyroid gland. While the majority of these tumors represent neoplasms of thyroid tissues, mainly of follicular epithelial cell differentiation, the differential diagnosis includes other lesions, such as C cell neoplasms (medullary thyroid carcinoma), intrathyroidal parathyroid, or thymic tumors, soft tissue tumors, and hematologic neoplasms as well as metastatic malignancies. Rare tumors are of salivary gland types. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00555
Publisher Site
http://dx.doi.org/10.3389/fendo.2018.00555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178136PMC
September 2018
6 Reads

Parathyroid carcinoma. A single Institution experience and a review of the international literature.

Ann Ital Chir 2018 ;89:295-304

Introduction: Parathyroid carcinoma (PC) is a slow-growing and very rare malignancy, representing less than 0.005% of all cancers. The rarity of PC makes it hard to create large-scale published series of patients affected by this condition. Read More

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January 2018
9 Reads