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    12609 results match your criteria Parathyroid Carcinoma

    1 OF 253

    Dual Pathologies of Parathyroid Adenoma and Papillary Thyroid Cancer on Fluorocholine and Fluorodeoxyglucose PET/CT.
    Nucl Med Mol Imaging 2018 Apr 25;52(2):154-158. Epub 2017 Jul 25.
    1Department of Nuclear Medicine, PGIMER, Sector-12, Chandigarh, 160012 India.
    F-Fluorocholine (FCH) PET/CT is evolving as a functional imaging modality for the preoperative imaging of abnormal parathyroid tissue(s) helping to localize eutopic and ectopic parathyroid tissue and limit the extent of surgery. FCH PET/CT may show incidental uptake in various thyroid lesions necessitating further evaluation, whereas the role of F-fluorodeoxyglucose (FDG) PET/CT in the detection of incidental thyroid nodules is well documented. The case of a middle-aged woman with dual pathology of parathyroid adenoma and papillary thyroid cancer detected on FCH and FDG PET/CT is presented. Read More

    Uptake of Tc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma.
    J Endocr Soc 2018 Apr 23;2(4):386-390. Epub 2018 Mar 23.
    Service of Endocrinology, Diabetology and Metabolism, CHUV, Lausanne University Hospital, Lausanne, Switzerland.
    Technetium-99m methoxy isobutyl isonitrile (Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2. Read More

    The use of PET/CT in pregnancy: A case report of malignant parathyroid carcinoma and a review of the literature.
    Obstet Med 2018 Mar 9;11(1):45-49. Epub 2017 Oct 9.
    1Department of Medicine, University of Alberta, Edmonton, Canada.
    Positron emission tomography scanning is not commonly performed in pregnancy but can be done if required. Fetal doses of radiation can be minimized, and our case exemplifies the safe application of positron emission tomography/computed tomography in pregnancy. A 38-year-old woman in her first ongoing pregnancy presented at 28 weeks' gestation with symptomatic hypercalcemia. Read More

    Nonfunctioning parathyroid carcinoma associated with parathyromatosis. A case report.
    Cesk Patol 2018 ;54(1):37-42
    We report on the case of a 39-year old man who underwent a thyroidectomy and a parathyroidectomy with misdiagnosed medullary carcinoma of the thyroid in 2013. During the operation the thyroid gland and parathyroid glands were artificially damaged due to the complicated surgical access to the glands because of the obesity of the patient as well as the deep placement of the enlarged parathyroid glands. Three years later, the neck ultrasound showed bilateral nodules on the neck, suspected to be metastases of the medullary carcinoma. Read More

    Immunohistochemistry in Diagnostic Parathyroid Pathology.
    Endocr Pathol 2018 Apr 7. Epub 2018 Apr 7.
    Department of Pathology, Laboratory Medicine Program, University Health System, Toronto, Canada.
    Pathologists are usually readily able to diagnose parathyroid tissues and diseases, particularly when they have knowledge of the clinical information, laboratory findings, and radiographic imaging studies. However, the identification of parathyroid tissue or lesions can be difficult in small biopsies, ectopic locations, supranumerary glands, and in some oxyphil/oncocytic lesions. Widely available immunohistochemical studies such as chromogranin-A, synaptophysin, keratin, parathyroid hormone, thyroglobulin, and thyroid transcription factor-1 can help in difficult cases. Read More

    Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma.
    BMC Cancer 2018 Apr 5;18(1):390. Epub 2018 Apr 5.
    Thyroid and Parathyroid Surgery Group of West China Hospital of Sichuan University, Chengdu, China.
    Background: Hyperfibrinogenemia is increasingly being recognized as an important risk factor related to cancer stage, development and outcomes. We evaluated whether preoperative serum fibrinogen levels predict recurrence of papillary thyroid carcinoma (PTC).

    Methods: We retrospectively collected data for 1023 PTC patients who underwent surgery at our institution from Aug 2014 to Aug 2016. Read More

    Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism.
    Case Rep Obstet Gynecol 2018 21;2018:2091082. Epub 2018 Jan 21.
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes.

    Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Read More

    A Clinical Decision Support System Using Ultrasound Textures and Radiologic Features to Distinguish Metastasis From Tumor-Free Cervical Lymph Nodes in Patients With Papillary Thyroid Carcinoma.
    J Ultrasound Med 2018 Mar 30. Epub 2018 Mar 30.
    Solid Tumor Research Center, Faculty of Medicine, Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran.
    Objectives: This study investigated the potential of a clinical decision support approach for the classification of metastatic and tumor-free cervical lymph nodes (LNs) in papillary thyroid carcinoma on the basis of radiologic and textural analysis through ultrasound (US) imaging.

    Methods: In this research, 170 metastatic and 170 tumor-free LNs were examined by the proposed clinical decision support method. To discover the difference between the groups, US imaging was used for the extraction of radiologic and textural features. Read More

    Refractory hyperparathyroidism with a T3 bony lesion-differential diagnoses.
    Oxf Med Case Reports 2018 Mar 20;2018(3):omx109. Epub 2018 Mar 20.
    Department of Endocrinology & Diabetes, Barwon Health, Geelong, Vic 3220, Australia.
    We report a case of severe hyperparathyroidism complicated by osteitis fibrosa cystica in an 83-year-old man post-myocardial infarction. The lesions were evident on magnetic resonance imaging only. A diagnosis of parathyroid carcinoma was considered due to clinical appearance of the parathyroid intraoperatively and the presence of an invasive T3 lesion mimicking metastatic disease. Read More

    Role of calcium-sensing receptor, Galectin-3, Cyclin D1, and Ki-67 immunohistochemistry to favor in the diagnosis of parathyroid carcinoma.
    Indian J Pathol Microbiol 2018 Jan-Mar;61(1):22-26
    Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazit University, Faculty of Medicine, Ataturk Education and Research Hospital, Ankara, Turkey.
    Background: As histopathological findings of parathyroid carcinoma are not certain, the diagnosis of tumors with degenerative changes may be difficult. In these cases, immunohistochemical markers are beneficial. We aimed to research the acceptability of calcium-sensing receptor (CaSR), Galactin-3, Cyclin D1, and Ki-67 as helpful markers in parathyroid tumors in cases which are difficult to diagnose. Read More

    Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report.
    BMC Cancer 2018 03 16;18(1):300. Epub 2018 Mar 16.
    Department of Radiology, Japanese Red Cross Kochi Hospital, 2-13-51, Shinhonmachi, Kochi-city, Kochi, 780-8562, Japan.
    Background: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. Read More

    Primary Peritoneal Angiosarcoma Metastatic to Liver and Bone without History of Radiation Therapy.
    Case Rep Pathol 2018 9;2018:1257284. Epub 2018 Jan 9.
    Department of Pathology, Clarion Hospital, 1 Hospital Drive, Clarion, PA 16214, USA.
    Angiosarcoma is a rare vascular soft tissue tumor of endothelial origin most commonly seen in the elderly as a primary cutaneous head and neck malignancy. Furthermore, a peritoneal angiosarcoma is an exceedingly rare entity. This is the second case of primary peritoneal angiosarcoma reported in literature that is not associated with prior radiotherapy. Read More

    [Tympanic paraganglioma mimicking cholesteatoma: about a case].
    Pan Afr Med J 2017 20;28:169. Epub 2017 Oct 20.
    Service d'Endocrinologie-Diabétologie, Maladies Métaboliques et Nutrition, Laboratoire PCIM, FMPM, Université Cadi Ayyad, CHU Mohamed VI, CHU Mohamed VI, Marrakech, Maroc.
    Tympanic paragangliomas are common benign tumors of the middle ear, made up of neuroendocrine cells dispersed along the major vascular axes of the head, the neck and the vertebral column. The revealing symptoms are hearing loss and a pulsatile tinnitus. Otoscopy often shows pulsatile retrotympanic reddish mass. Read More

    [Hormone-producing thyroid carcinoma in a female 10-year-old Australian Cattle Dog].
    Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Feb 21;46(1):35-40. Epub 2018 Feb 21.
    A 10-year-old female Australian Cattle Dog was referred for investigation of a mediastinal mass. During clinical examination, a mandarin- sized mass was detected ventrally of the trachea. According to computed tomographic (CT) findings and cytology of a fine-needle aspirate, thyroid neoplasia was suspected. Read More

    Inhibition effects of total flavonoids from Sculellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway.
    Int J Mol Med 2018 Jun 27;41(6):3137-3146. Epub 2018 Feb 27.
    Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
    It is abundantly clear that tumor-derived parathyroid hormone-related protein (PTHrP), receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) are central contributors in promoting osteolytic process of breast carcinoma bone metastasis. Forcusing on this molecular basis, the study was undertaken to explore the inhibition effects of total flavonoids from Scutellaria barbata D. Don (TF-SB) on human breast carcinoma bone metastasis. Read More

    Setting up a parathyroid multidisciplinary team meeting: one year's experience, outcomes and learning points.
    J Laryngol Otol 2018 Mar;132(3):252-256
    Department of Radiology,Eastbourne District General Hospital,UK.
    Objective: A parathyroid multidisciplinary team meeting was set up at East Sussex Healthcare Trust, from November 2014 to November 2015, in order to improve and streamline services for patients with parathyroid pathology.

    Methods: Data were collected on all new referrals for hyperparathyroidism, and on the outcomes for each patient discussed at the meeting, including the number of operations and management outcomes. A survey was sent out to the members of the multidisciplinary team meeting to determine their perception of its effectiveness. Read More

    Review of Polymorphism of the Calcium-Sensing Receptor Gene and Breast Cancer Risk.
    Cancer Invest 2018 Feb 5;36(2):1-7. Epub 2018 Mar 5.
    a Postgraduate Program of Health in Sciences , Federal University of Piauí , 2280 Frei Serafim Avenue, Teresina , Piauí , Brazil.
    Polymorphism of the calcium-sensing receptor gene (CaSR or CaR) has been associated with an increased risk for breast cancer. This receptor plays an important role in calcium homeostasis, and has also been detected in several tissues that are unrelated to calcium metabolism, such as the skin, brain, and breast. The calcium-sensing receptor on cellular level, it regulates cell differentiation, proliferation, cell death, and gene expression. Read More

    Papillary Thyroid Carcinoma Recurrence: Low Yield of Neck Ultrasound With an Undetectable Serum Thyroglobulin Level.
    J Ultrasound Med 2018 Mar 2. Epub 2018 Mar 2.
    University of Virginia, Charlottesville, Virginia, USA.
    Objectives: To assess the yield of neck ultrasound (US) when serum thyroglobulin (Tg) is undetectable (<0.1 ng/mL) compared to elevated serum Tg in patients with differentiated papillary thyroid carcinoma (PTC) treated with thyroidectomy and radioactive iodine 131 (RAI) ablation.

    Methods: A retrospective chart review was conducted from 2010 through 2015 at an academic institution evaluating US results in patients with serum Tg levels obtained within 6 months of a neck US examination after thyroidectomy and RAI. Read More

    Verification of candidate microRNA markers for parathyroid carcinoma.
    Endocrine 2018 May 16;60(2):246-254. Epub 2018 Feb 16.
    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
    Purpose: Parathyroid carcinoma (PCa) is a rare endocrine malignancy with poor prognosis and is often difficult to accurately diagnose both before and after surgery. Dysregulated microRNA (miRNA) levels have been identified in PCa using a limited number of samples. The aim of the present study was to verify a group of miRNA markers in a new series of samples to explore their potential significance in PCa diagnosis. Read More

    A Nomogram Based on the Characteristics of Metastatic Lymph Nodes to Predict Papillary Thyroid Carcinoma Recurrence.
    Thyroid 2018 Mar;28(3):301-310
    1 Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University , Chengdu, China .
    Background: The extent of metastatic lymph node (LN) invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk.

    Methods: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in this study. Read More

    Rare and changeable as a chameleon: paraneoplastic syndromes in renal cell carcinoma.
    World J Urol 2018 Feb 10. Epub 2018 Feb 10.
    Department of Urology, Eberhard Karls University Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
    Introduction: Paraneoplastic syndromes (PNS) in renal cell carcinoma (RCC) are important to be recognized by the treating physician, because they may lead to diagnosis of underlying malignant disease. On the other hand, PNS may dominate the clinical picture and can hide the true disorder like a chameleon. When realized, a PNS can be used as a 'neoplastic tumour marker', especially in case of recurrence. Read More

    CUNR scoring system for the prediction of lateral lymph node metastasis in papillary thyroid carcinoma.
    Oncotarget 2018 Jan 30;9(1):167-177. Epub 2017 Nov 30.
    Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu 610041, China.
    Objective: Our present study aimed to evaluate and compare the number and rate of central lymph node metastases (LNMs) for the prediction of lateral LNM (LLNM) in papillary thyroid carcinoma (PTC) and to develop a scoring system.

    Results: Capsule invasion, tumor location in the upper portion of the thyroid, an ipsilateral central compartment LNM number ≥3, and an ipsilateral central compartment LNM rate of ≥56% were identified as significant independent predictors of ipsilateral lateral LNM in PTC. The predictive ability of an ipsilateral central compartment LNM rate ≥56% (area under the curve (AUC) = 0. Read More

    Probability of Positive Genetic Testing Results in Patients with Family History of Primary Hyperparathyroidism.
    J Am Coll Surg 2018 Mar 2. Epub 2018 Mar 2.
    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, DC. Electronic address:
    Background: Approximately 10% of patients with primary hyperparathyroidism (PHPT) have hereditary disease. Hereditary PHPT may be syndromic (MEN1, 2, and 4 and hyperparathyroidism-jaw tumor syndrome) or non-syndromic (familial isolated PHPT). There are limited data on the probability of testing positive for genetic mutation based on clinical presentation. Read More

    Does the number of parathyroid glands autotransplanted affect the incidence of hypoparathyroidism and recovery of parathyroid function?
    Surgery 2018 Feb 2. Epub 2018 Feb 2.
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address:
    Background: The relationship between the number of parathyroid glands autotransplanted and hypoparathyroidism as well as recovery of parathyroid function is not understood fully. The aim was to ascertain whether the number of autotransplanted glands affected the incidence of hypoparathyroidism and recovery of parathyroid function in long-term follow-up after thyroidectomy.

    Methods: A retrospective cohort study included all patients with papillary thyroid carcinoma who underwent first-time total thyroidectomy with central neck dissection between June 2012 and June 2015. Read More

    [A comparison of clinical characteristics between 2 pedigrees of multiple endocrine neoplasia type 2A with different RET mutations].
    Zhonghua Nei Ke Za Zhi 2018 Feb;57(2):134-137
    Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
    Multiple endocrine neoplasia type 2A (MEN2A) is a hereditary syndrome. Here, two different RET proto-oncogen mutation were identified from family members of two MEN2A pedigrees by genetic screening. One RET mutations were found at codons 1893 and 1895 in exon 11 (1893-1895delCGA) from pedigree 1, which is a novel mutation, the other occurs at codon 634 (Cys634Arg) in exon 11 from pedigree 2. Read More

    Influence of magnesium and parathyroid hormone on cisplatin-induced nephrotoxicity in esophageal squamous cell carcinoma.
    Oncol Lett 2018 Jan 3;15(1):658-664. Epub 2017 Nov 3.
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
    Magnesium (Mg) supplementation has previously been demonstrated to confer protective effects against nephrotoxicity induced by cisplatin. Parathyroid hormone (PTH) regulates Mg homeostasis. The aim of present study was to determine the protective effects of Mg supplementation against cisplatin-induced nephrotoxicity and its association with PTH levels in patients with esophageal squamous cell carcinoma (ESCC). Read More

    Anesthetic management of primary hyperparathyroidism during pregnancy: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9390
    Department of Anesthesiology, Peking University Third Hospital, Beijing, China.
    Rationale: Primary hyperparathyroidism (PHPT) during pregnancy is rare. Nevertheless, hypercalcemia secondary to gestational PHPT may be masked by physiological changes in calcium homeostasis during pregnancy. Gestational PHPT constitutes a serious danger to mother and fetus. Read More

    Superior mediastinal typical carcinoid detected by 99mTc-MIBI SPECT/CT imaging: A case report.
    Medicine (Baltimore) 2017 Dec;96(52):e9457
    Rationale: This is a rare case of mediastinal typical carcinoid tumor with elevated parathyroid hormone (PTH) and hypercalcemia detected by Tc -methoxy-isobutyl-isonitrile(Tc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT) imaging.

    Patient Concerns: A 65-year-old male patient presented with hypercalcemia and elevated PTH.

    Diagnoses: The preoperative diagnosis was ectopic parathyroid adenoma in the right superior mediastinum. Read More

    Independent predictors and lymph node metastasis characteristics of multifocal papillary thyroid cancer.
    Medicine (Baltimore) 2018 Feb;97(5):e9619
    Thyroid and Parathyroid Surgery Center, West China Hospital.
    The multifocal papillary thyroid cancer (PTC), with more aggressive and poorer prognosis, is not rare in papillary histotype. Few studies evaluated risk factors and lymph node metastasis in multifocal PTC. The aim of this present study focusing on risk factors and lymph node metastasis characteristics in multifocal PTC was excepted to assist clinical decisions regarding surgery. Read More

    Parathyroid carcinoma: an unusual presentation of a rare neoplasm.
    Ger Med Sci 2017 28;15:Doc21. Epub 2017 Dec 28.
    National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
    Parathyroid carcinoma is an extremely rare malignant endocrine neoplasm that is very challenging in its diagnosis as well as its treatment. Clinically the disease is detected earlier in patients who present with hyperparathyroidism with signs of profound hypercalcemia. Differentiation between benign and malignant disease of the parathyroid is challenging both for the clinician and for the pathologist. Read More

    Parathyroid carcinoma: From a case report to a review of the literature.
    Int J Surg Case Rep 2018 22;42:214-217. Epub 2017 Nov 22.
    Serviço de Cirurgia Geral, Centro Hospitalar do Porto, Hospital Santo António, Porto, Portugal.
    Introduction: Parathyroid carcinoma is a rare endocrine malignancy. The reported incidence is from 0.5 to 5% of primary hyperparathyroidism cases in various series. Read More

    Non-mammalian models of multiple endocrine neoplasia type 2.
    Endocr Relat Cancer 2018 Feb;25(2):T91-T104
    Department of Cell Developmental and Regenerative Biology, School of Biomedical Sciences, Icahn School of Medicine, New York, New York, USA
    Twenty-five years ago, RET was identified as the primary driver of multiple endocrine neoplasia type 2 (MEN2) syndrome. MEN2 is characterized by several transformation events including pheochromocytoma, parathyroid adenoma and, especially penetrant, medullary thyroid carcinoma (MTC). Overall, MTC is a rare but aggressive type of thyroid cancer for which no effective treatment currently exists. Read More

    Clinical characteristics and treatment outcomes of parathyroid carcinoma: A retrospective review of 234 cases.
    Oncol Lett 2017 Dec 27;14(6):7276-7282. Epub 2017 Sep 27.
    Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
    Parathyroid carcinoma (PC) is one of the rarest known types of cancer and has a moderate prognosis, with estimated 5- and 10-year overall survival rates between 78-85% and between 49-70%, respectively. To raise awareness of this disease, and to optimize its diagnosis, clinical management and prognosis, the present study retrospectively reviewed 234 cases of PC. A total of 226 cases of PC, which were archived between 1984 and 2015 in the three major databases of the Chinese population, were retrieved and pooled with the 8 cases diagnosed and treated at the Department of Thyroid Surgery of The First Hospital of Jilin University (Changchun, China) between June 2008 and December 2015. Read More

    Squamous Cell Carcinoma Lung with Skeletal Muscle Involvement: A 8-year Study of a Tertiary Care Hospital in Kashmir.
    Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):456-460
    Department of Medical Oncology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
    Aims: Lung cancer is the most common malignancy throughout the world. Nonsmall cell lung cancer (NSCLC) is the most common type, and squamous cell type is most common in India. Mostly, patients present with chest-related symptoms and signs. Read More

    Diagnosis, management, histology and genetics of sporadic primary hyperparathyroidism: old knowledge with new tricks.
    Endocr Connect 2018 Feb 12;7(2):R56-R68. Epub 2018 Jan 12.
    Department of Thyroid and Endocrine SurgeryImperial College London, London, UK.
    Primary hyperparathyroidism (pHPT) is a common endocrinopathy resulting from inappropriately high PTH secretion. It usually results from the presence of a single gland adenoma, multiple gland hyperplasia or rarely parathyroid carcinoma. All these conditions require different management, and it is important to be able to differentiate the underlined pathology, in order for the clinicians to provide the best therapeutic approach. Read More

    gene mutations in endocrine tumors.
    Endocr Relat Cancer 2018 Mar 12;25(3):R197-R208. Epub 2018 Jan 12.
    Division of PathologyDepartment of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
    In this review, the importance of the gene in the function of endocrine cells is discussed. There is conclusive evidence that mutations play a crucial role in the development, progression, cell proliferation, therapeutic responsiveness and behavior of several endocrine tumors. We review the literature of gene mutations in thyroid, parathyroid, pituitary, pineal gland, endocrine pancreas, paragangliomas, medullary, adrenocortical, ovarian and testicular tumors. Read More

    Parafibromin-deficient (HPT-JT Type, CDC73 Mutated) Parathyroid Tumors Demonstrate Distinctive Morphologic Features.
    Am J Surg Pathol 2018 Jan 10. Epub 2018 Jan 10.
    Sydney Medical School, University of Sydney, Sydney.
    The gene CDC73 (previously known as HRPT2) encodes the protein parafibromin. Biallelic mutation of CDC73 is strongly associated with malignancy in parathyroid tumors. Heterozygous germline mutations cause hyperparathyroidism jaw tumor syndrome,which is associated with a high life-time risk of parathyroid carcinoma. Read More

    Synchronous parathyroid adenoma and papillary thyroid carcinoma: 99mTc-MIBI Scan Findings.
    Niger J Clin Pract 2017 Nov;20(11):1510-1512
    Department of Radiology, Cumhuriyet University Hospital, Sivas, Turkey.
    Simultaneous existence of parathyroid adenoma and thyroid nonmedullary carcinoma is rarely observed. A 52-year-old female was diagnosed approximately 4 years ago with primary hyperparathyroidism (PHPT) on the basis of hypercalcemia and elevated serum parathyroid hormone (PTH) level. Clinically, PHPT diagnosed patient was examined with Tc-99m MIBI scintigraphy to investigate parathyroid adenoma. Read More

    Effect of autotransplantation of a parathyroid gland on hypoparathyroidism after total thyroidectomy.
    Endocr Connect 2018 Feb 4;7(2):286-294. Epub 2018 Jan 4.
    Department of Thyroid Surgery, West China Hospital, Sichuan UniversityChengdu, China.
    Background: The effect of parathyroid autotransplantation on hypoparathyroidism is not fully understood. The purpose of the study was to determine the effect of autotransplantation of a parathyroid gland on the incidence of hypoparathyroidism and recovery of parathyroid function at 6 months after total thyroidectomy with central neck dissection for papillary thyroid carcinoma.

    Methods: All patients with autotransplantation of a parathyroid gland (no inadvertent parathyroidectomy) (group A), preservation of all parathyroid glands (no autotransplantation and inadvertent parathyroidectomy) (group B) or inadvertent removal of a parathyroid gland (no autotransplantation) (group C) who underwent first-time total thyroidectomy with central neck dissection for papillary thyroid carcinoma between January 2013 and June 2016 were included retrospectively. Read More

    Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3195-3200. Epub 2017 Dec 28.
    Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. Read More

    Non-functioning parathyroid cystic tumour: malignant or not? Report of a case.
    G Chir 2017 Sep-Oct;38(5):243-249
    Parathyroid carcinoma (PC) is a very rare endocrine tumour, usually characterized by symptoms such as a neck mass, dysphonia, severe hypercalcemia exceeding 140 mg/L and elevated serum parathyroid hormone levels, even more than 5 times the upper limit of normal. Non-functioning parathyroid cancer is extremely rare and, in this case, its pre-operative diagnosis is often difficult. A 54-year old female patient, referring dysphagia and dysphonia, underwent neck ultrasound and neck CT. Read More

    Decreased expression of PTH1R is a poor prognosis in hepatocellular carcinoma.
    Cancer Biomark 2018 Feb;21(3):723-730
    Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
    Background And Aim: Hypercalcemia is a potentially fatal and not rare complication of hepatocellular carcinoma (HCC), and its underlying mechanism remains unclear. Parathyroid hormone (PTH) is the most important regulator of the concentrations of calcium and phosphate in blood; parathyroid hormone-related protein (PTHrP) was the most frequent cause of humoral hypercalcemia of malignancy; parathyroid hormone 1 receptor (PTH1R) is the common receptor for PTH and PTHrP. The aim of this study is to investigate the expression of PTH, PTHrP, and PTH1R in HCC tissues, and their relationship with clinical pathological characters in HCC. Read More

    Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion.
    J Endocr Soc 2017 Jul 25;1(7):926-930. Epub 2017 May 25.
    Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine, New Haven, Connecticut 06520.
    Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a rare autosomal dominant cause of familial hyperparathyroidism associated with benign, ossifying fibromas of the maxillofacial bones and increased risk of parathyroid carcinoma. The putative tumor suppressor gene has been implicated in the syndrome, with a multitude of inactivating mutations identified; however, HPT-JT due to large-scale deletion of the chromosomal region containing the gene is exceedingly rare, and the clinical significance of this variant remains unclear. We report the case of a 32-year-old woman with a history of mandibular ossifying fibroma who presented with primary hyperparathyroidism and was found to harbor a large-scale, germline deletion on chromosome 1q31, including the locus. Read More

    An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma.
    Turk J Surg 2017 1;33(4):243-247. Epub 2017 Dec 1.
    Department of General Surgery, Ümraniye Training and Research Hospital, İstanbul, Turkey.
    Objective: To evaluate the clinical characteristics of a patient operated for water-clear cell adenoma and to discuss these in the light of relevant literature.

    Material And Methods: PubMed and Google Scholar were searched to identify articles related to water-clear cell adenoma using the following keywords: parathyroid tissue, parathyroid gland, parathyroid cells, parathyroid adenoma, parathyroid hyperplasia, water-clear-cell, and water clear cell. The search included case reports, review articles, and original articles that had been published between January 1990 and November 2014 without any restrictions on language. Read More

    Clinical Characteristics, Causes and Survival in 115 Cancer Patients with Parathyroid Hormone Related Protein-mediated Hypercalcemia.
    J Bone Metab 2017 Nov 30;24(4):249-255. Epub 2017 Nov 30.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
    Background: The aim of this study is to determine the proportion of cancers presenting with parathyroid hormone (PTH) related protein (PTHrP)-mediated hypercalcemia, examine the clinical and biochemical characteristics, identify predictive factors for survival. And we also compared those characteristics between solid organ and hematologic malignancy groups.

    Methods: Cancer patients with PTHrP-mediated hypercalcemia who were treated at Chonnam National University Hospital in Korea from January 2005 to January 2015 were retrospectively reviewed. Read More

    Pathological bone fractures in a patient with parathyroid carcinoma - A Case Report.
    J Pak Med Assoc 2017 Dec;67(12):1956-1958
    Services Institute of Medical Sciences, University of Health Sciences, Lahore, Pakistan.
    Parathyroid carcinoma is a rare malignant neoplasm of the parathyroid glands which results in enlargement and excessive production of parathyroid hormone (PTH) responsible for pathologically raising calcium levels in the blood resulting in bone pain/fractures, renal stones and other signs of hypercalcaemia. A 37 year old woman presented with sudden, spontaneous bone pain and fracture of the right femoral shaft. This unusual presentation was explained by extremely high PTH levels and hypercalcaemia in the blood and a hard, solitary mass palpable in the neck. Read More

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