4,583 results match your criteria Paraspinal Injections - Facet Joint and Nerve Root Blocks


Non-Fusion Muscle-Sparing Technique to Treat Long-Segment Thoracolumbar Extradural Arachnoid Cyst in a Child: A Case Report and Review of the Literature.

World Neurosurg 2020 Jun 29. Epub 2020 Jun 29.

Department of Orthopedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Introduction: Spinal extradural arachnoid cyst (SEAC) is an uncommon cause of spinal cord compression. It results from a small dural defect that leads to cerebrospinal fluid (CSF) accumulation in the cyst and subarachnoid space, and the cyst can compress the spinal cord and nerve roots. Surgery is the treatment of choice in symptomatic patients, and most cases have an immediately satisfying outcome after surgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.185DOI Listing

Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations.

JOR Spine 2020 Jun 6;3(2):e1091. Epub 2020 May 6.

Department of Orthopaedic Surgery University of California San Francisco California USA.

Background: Paraspinal muscles are crucial for vertebral stabilization and movement. These muscles are prone to develop fatty infiltration (FI), fibrosis, and atrophy in many spine conditions. Fibro-adipogenic progenitors (FAPs), a resident muscle stem cell population, are the main contributors of muscle fibrosis and FI. Read More

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http://dx.doi.org/10.1002/jsp2.1091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323461PMC

Cell populations and muscle fiber morphology associated with acute and chronic muscle degeneration in lumbar spine pathology.

JOR Spine 2020 Jun 8;3(2):e1087. Epub 2020 Apr 8.

Department of Orthopaedic Surgery University of California San Diego San Diego California USA.

Many chronic musculoskeletal conditions are associated with loss of muscle volume and quality, resulting in functional decline. While atrophy has long been implicated as the mechanism of muscle loss in these conditions, recent evidence has emerged demonstrating a degenerative phenotype of muscle loss consisting of disrupted muscle fiber membranes, infiltration of cells into muscle fibers, and as previously describer, possible replacement of muscle fibers by adipose tissue. Here, we use human lumbar spine pathology as a model system to provide a more comprehensive analysis of the morphological features of this mode of muscle loss between early and late stages of disease, including an analysis of the cell populations found in paraspinal muscle biopsies from humans with acute vs chronic lumbar spine pathology. Read More

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http://dx.doi.org/10.1002/jsp2.1087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323470PMC

Benefits of a four-week functional restoration program in chronic low back pain patients and three-month follow-up: focus on paraspinal muscle aerobic metabolism responses to exercise.

J Sports Med Phys Fitness 2020 Jun 30. Epub 2020 Jun 30.

ULR 7369 - URePSSS, Unité de Recherche Pluridisciplinaire Sport Santé Société, Université Lille, Université Artois, Université Littoral Côte d'Opale, Lille, France.

Background: Chronic low back pain (CLBP) is a major health concern characterized by paraspinal muscle fatigability. This can be improved following a functional restoration program. Muscle fatigability can be related to impairment in aerobic metabolism responses. Read More

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http://dx.doi.org/10.23736/S0022-4707.20.11113-7DOI Listing

A novel two-stage open spine and robotic thoracic approach to resection of a mediastinal tumor.

Ann Thorac Surg 2020 Jun 26. Epub 2020 Jun 26.

Thomas Jefferson University Hospital.

Posterior mediastinal dumbbell tumors are rare and dumbbell tumors of non-neurogenic origin are even more infrequent. Here, we discuss a novel surgical approach to resection. A 60 year old male presented with several years of bilateral lower extremity weakness. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.043DOI Listing

Spinal Cord Infarction after Transcatheter Embolization of Pelvic Arteriovenous Malformation.

Ann Vasc Dis 2020 Jun;13(2):176-179

Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.

An 80-year-old woman presented with abdominal and right lower limb pain. Radiological examination revealed pelvic arteriovenous malformations (pAVMs). Although transarterial embolization was repeated, dilation of the common iliac vein worsened. Read More

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http://dx.doi.org/10.3400/avd.cr.19-00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315244PMC

Paraspinal back muscles in asymptomatic volunteers: quantitative and qualitative analysis using computed tomography (CT) and magnetic resonance imaging (MRI).

BMC Musculoskelet Disord 2020 Jun 26;21(1):403. Epub 2020 Jun 26.

Department of Neurosurgery, Hallym University Dongtan Sacred Heart Hospital, 7, Keunjaebong-gil, Hwaseong-si, Gyeonggi-do, 18450, South Korea.

Background: To evaluate paraspinal back muscles of asymptomatic subjects using qualitative and quantitative analysis on CT and MRI and correlate the results with demographic data.

Methods: Twenty-nine asymptomatic subjects were enrolled prospectively (age: mean 34.31, range 23-50; 14 men, 15 women) from August 2016 to April 2017. Read More

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http://dx.doi.org/10.1186/s12891-020-03432-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320566PMC

Incidental Durotomy Following Transforaminal Lumbar Interbody Fusion Performed with the Modified Wiltse Approach.

J Neurol Surg A Cent Eur Neurosurg 2020 Jun 25. Epub 2020 Jun 25.

Department of Orthopaedics, Meir Medical Center, Kfar Saba, Israel.

Purpose:  Incidental durotomy is an intraoperative complication that occurs in 3 to 27% of lumbar spine surgeries. It has been reported more commonly following revision spinal procedures.

Study Objectives:  To investigate the frequency of incidental durotomy while performing transforaminal lumbar interbody fusion (TLIF) using the modified Wiltse approach. Read More

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http://dx.doi.org/10.1055/s-0039-1698390DOI Listing

Axial or Helical? CT imaging of the thorax for dyspnoea patients with free-breathing using 16 cm wide-detector CT.

Clin Radiol 2020 Jun 23. Epub 2020 Jun 23.

Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Aim: To compare image quality and radiation dose between fast-helical mode (FHM) and two-axial mode (TAM) in chest computed tomography (CT) with 16 cm wide-detector for emergency patients with dyspnoea.

Materials And Methods: Ninety-six emergency chest CT patients who cannot comply with breathing instructions were prospectively divided randomly into two groups: the FHM group (n=48, helical scan with 80 mm collimation and pitch 0.992:1), the TAM group (n=48, two axial scans with 160 mm collimation). Read More

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http://dx.doi.org/10.1016/j.crad.2020.05.014DOI Listing

Permanent muscle weakness in hypokalemic periodic paralysis.

Neurology 2020 Jun 24. Epub 2020 Jun 24.

From the Copenhagen Neuromuscular Center, Department of Neurology (S.H.-Y., N.W., J.D., J.d.S.B., T.S., F.F., A.-S.E., J.V.), and Department of Clinical Genetics (M.D.), Rigshospitalet, University of Copenhagen; and Neurology Practice (T.S.), Herlev, Denmark.

Objective: To map the phenotypic spectrum in 55 individuals with mutations in known to cause hypokalemic periodic paralysis (HypoPP) using medical history, muscle strength testing, and muscle MRI.

Methods: Adults with a mutation in known to cause HypoPP were included. Medical history was obtained. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009828DOI Listing

Tissue fat quantification by magnetic resonance imaging: proton density fat fraction in polycystic ovary syndrome.

Reprod Biomed Online 2020 May 15. Epub 2020 May 15.

Division of Endocrinology and Metabolism, Hacettepe University School of Medicine, Hacettepe Ankara 06100, Turkey; Department of Internal Medicine, Hacettepe University School of Medicine, Hacettepe Ankara 06100, Turkey. Electronic address:

Research Question: What are the potential differences between lean women with and without polycystic ovary syndrome (PCOS) in fat content in liver, vertebrae, paraspinal muscles, pancreas, subcutaneous (SCAT) and visceral adipose tissue (VAT)? Magnetic resonance imaging proton density fat fraction (PDFF) was used to establish these differences. This is a novel, non-invasive, operator-independent method with comparable diagnostic sensitivity and specificity to histologic examination for fatty liver disease, and strong correlation with muscle strength in neuromuscular studies.

Design: Twenty lean women with PCOS (mean age 23. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.04.024DOI Listing

The effect of paraspinal muscle on functional status and recovery in patients with lumbar spinal stenosis.

J Orthop Surg Res 2020 Jun 23;15(1):235. Epub 2020 Jun 23.

Department of Orthopaedics, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.

Purpose: To investigate the association of paraspinal muscle quantity and quality with functional status in patients with lumbar spinal stenosis (LSS) and explore whether degeneration of paraspinal muscle could predict patients' functional recovery.

Methods: The data of 69 patients (26 males, 43 females; mean age 60.6 ± 9. Read More

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http://dx.doi.org/10.1186/s13018-020-01751-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310429PMC

Reciprocal relationship between multifidus and psoas at L4-L5 level in women with low back pain.

Br J Neurosurg 2020 Jun 24:1-9. Epub 2020 Jun 24.

School of Medicine, Department of Neurosurgery, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.

Low back pain (LBP) may originate from different sources such as intervertebral disc degeneration (IVDD), end-plate and paraspinal muscle changes. Our aim is to explore the relevance of paraspinal muscles' fat-infiltration in women with LBP and its association with IVDD and Modic changes. Consecutive female patients presenting with chronic LBP to the outpatient clinics were included. Read More

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http://dx.doi.org/10.1080/02688697.2020.1783434DOI Listing

Sagittal imbalance, muscle atrophy, and osteoporosis: risk factors for revision posterior lumbar fusion surgery in patients with Parkinson's disease.

Int Orthop 2020 Jun 20. Epub 2020 Jun 20.

Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: The aim of our study was to evaluate features and complications of patients with Parkinson's disease (PD) who underwent posterior lumbar fusion surgery for lumbar degenerative diseases (LDD), as well as the risk factors for revision.

Methods: Between January 2010 and December 2016, 132 patients were retrospectively identified for inclusion. Patients were divided into a 29 revision PD group and a 103 non-revision PD group. Read More

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http://dx.doi.org/10.1007/s00264-020-04666-yDOI Listing

Minimally invasive treatment of retrocardiac tension pneumomediastinum in an extremely low birth weight infant.

Pediatr Radiol 2020 Jun 20. Epub 2020 Jun 20.

Interventional Radiology, Children's National Hospital, 111 Michigan Ave. NW, Washington, DC, 20010, USA.

A 23.4-week premature and extremely low birth weight neonate was transferred to the Neonatal Intensive Care Unit for management of respiratory failure and retrocardiac pneumomediastinum, suspected to be the result of a low tracheal injury during intubation. Initial conservative management failed and chest radiographs demonstrated worsening retrocardiac pneumomediastinum. Read More

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http://dx.doi.org/10.1007/s00247-020-04712-2DOI Listing
June 2020
1.651 Impact Factor

Cervical epidural neurosarcoidosis: A case report and literature review.

Surg Neurol Int 2020 30;11:133. Epub 2020 May 30.

Division of Neurosurgery, Department of Surgery, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia.

Background: Neurosarcoidosis is a rare disease. In the spine, it commonly presents as an intramedullary lesion. Epidural spinal lesions are extremely rare. Read More

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http://dx.doi.org/10.25259/SNI_174_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294160PMC

Age- and BMI-related variations of fat distribution in sacral and lumbar bone marrow and their association with local muscle fat content.

Sci Rep 2020 Jun 16;10(1):9686. Epub 2020 Jun 16.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

This analysis investigated the age- and BMI-related variations of fat distribution in sacral and lumbar bone marrow and their association with local muscle fat content in order to detect fat distribution patterns and variations in healthy adults using proton density fat fraction (PDFF) measurements. A six-echo 3D spoiled gradient-echo sequence was used for chemical shift encoding-based water-fat separation at the sacral and lower lumbar region in 103 healthy volunteers. PDFF values of the sacrum, 5 lumbar vertebral body, the gluteal and paraspinal muscles were determined. Read More

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http://dx.doi.org/10.1038/s41598-020-66649-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297969PMC

Primary giant hydatid cyst of lumbar paraspinal muscles.

World Neurosurg 2020 Jun 12. Epub 2020 Jun 12.

Department of Neurosurgery, Government Medical College & Hospital, Chandigarh, India.

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http://dx.doi.org/10.1016/j.wneu.2020.06.061DOI Listing

Quantitative electromyography: Normative data in paraspinal muscles.

Muscle Nerve 2020 Jun 12. Epub 2020 Jun 12.

Dep. of Clinical Neurophysiology, Rigshospitalet, University of Copenhagen.

Introduction: Quantitative electromyography of paraspinal muscle is a valuable diagnostic tool, but normative data are lacking.

Methods: EMG was obtained in 65 healthy subjects (49% men, 51% women) aged 21-82 years at C7, Th10, and L5 segments bilaterally. The incidence of spontaneous activity; motor unit potential (MUP) amplitudes, durations, and the incidence of polyphasic potentials; and the recruitment pattern at maximal voluntary contraction (MVC) were evaluated. Read More

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http://dx.doi.org/10.1002/mus.27000DOI Listing

Long-term Outcomes of Patients With Fungal Infections Associated With Contaminated Methylprednisolone Injections.

Open Forum Infect Dis 2020 Jun 9;7(6):ofaa164. Epub 2020 May 9.

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: The largest health care-associated infection outbreak in the United States occurred during 2012-2013. Following injection of contaminated methylprednisolone, 753 patients developed infection with a dematiaceous mold, . The long-term outcomes of these infections have not been described. Read More

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http://dx.doi.org/10.1093/ofid/ofaa164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275232PMC

HYPERCALCEMIA OF MALIGNANCY IN A CASE OF PERIPHERAL NERVE SHEATH TUMOR: ELUCIDATING THE ROLES OF SIMULTANEOUS MECHANISMS.

AACE Clin Case Rep 2020 May-Jun;6(3):e135-e140. Epub 2020 May 8.

Objective: Hypercalcemia of malignancy (HCM) is caused by 1 of 5 known mechanisms including systemic release of ectopic parathyroid hormone (PTH)-related protein (PTHrP), calcitriol, PTH, cytokines, or destruction of bone by osteolytic metastases. We report the first case of 2 simultaneous mechanisms for HCM in a patient with a peripheral nerve sheath tumor (PNST).

Methods: PubMed and Google Scholar searches were performed using "hypercalcemia of malignancy" as the search term. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282278PMC

Learning from mistakes: Pancreatic laceration - Devastating complication during spine surgery.

World Neurosurg 2020 Jun 6. Epub 2020 Jun 6.

Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.

Background: Posterior decompression & fusion surgery is one of commonest performed surgery for thoracolumbar tuberculosis with destruction of vertebral bodies. Tuberculosis causes gross destruction of the vertebral bodies and surrounding tissue, making them friable.

Case Description: We present an unusual but dreaded complication which we encountered during posterior decompression and instrumentation surgery in a 65-year-old female with T10-T11 tuberculosis of spine. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.261DOI Listing

Survival After Surgery for Renal Cell Carcinoma Metastatic to the Spine: Impact of Modern Systemic Therapies on Outcomes.

Neurosurgery 2020 Jun 10. Epub 2020 Jun 10.

Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: Modern medical management of metastatic renal cell carcinoma (RCC) includes therapies targeting tyrosine kinases, growth pathways (mammalian target of rapamycin (mTOR)), and immune checkpoints.

Objective: To test our hypothesis that patients with spinal metastases would benefit from postoperative systemic therapy despite presenting with disease that, in many cases, was resistant to prior systemic therapy.

Methods: This is an Institutional Review Board-approved clinical retrospective cohort analysis. Read More

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http://dx.doi.org/10.1093/neuros/nyaa224DOI Listing

Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.

J Pediatr Hematol Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Pediatric Oncology, Hacettepe University Faculty of Medicine.

Primary paraspinal/spinal epidural lymphoma (PPSEL) is rare in childhood. Here, we retrospectively evaluated patients with PPSEL treated in our department. We also reviewed the cases reported in the literature. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001858DOI Listing

The Novel Costotransverse Foramen Block Technique: Distribution Characteristics of Injectate Compared with Erector Spinae Plane Block.

Pain Physician 2020 Jun;23(3):E305-E314

Department of Anatomy, Chulalongkorn University, Bongkok, Thailand.

Background: The costotransverse foramen (CTF) is a space continuous with the paravertebral space. We hypothesized that injections passing through the CTF will result in a successful injectate spread to the paravertebral space.

Objectives: We investigated patterns of dye spread to assess characteristics of neural blockade following ultrasound-guided CTF and erector spinae plane (ESP) injection in an anatomic and clinical study. Read More

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[Comparision of surgical outcomes between percuteneous endoscopic interlaminar discectomy and fenestration discectomy for L₅S₁ lumbar disc herniation].

Zhongguo Gu Shang 2019 Oct;32(10):933-936

Department of Spinal Surgery, the First People's Hospital of Jining, Jining 272111, Shandong, China.

Objective: To investigate the clinical effects of percuteneous endoscopic interlaminar discectomy(PEID)and fenestration discectomy(FD) for the treatment of L₅S₁ lumbar disc herniation(LDH).

Methods: A retrospective analysis was made on 86 patients with L₅S₁ LDH from January 2014 to March 2017 and followed up. According to the different surgical methods, the patients were divided into PEID group(43 cases) and FD group(43 cases). Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.10.012DOI Listing
October 2019

[Surgical treatment of deep infection around the spine].

Zhongguo Gu Shang 2019 Oct;32(10):886-891

Department of Orthopaedics, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China;

Objective: To study the surgical method and clinical effect of deep infection around the spine.

Methods: The clinical data of 7 patients with deep infections around the spine treated from January 2015 to January 2018 were retrospectively analyzed. All patients were acute infection within 3 weeks after spinal surgery. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.10.003DOI Listing
October 2019

Sex-Based Differences in Tensiomyography as Assessed in the Lower Erector Spinae of Healthy Participants: An Observational Study.

Sports Health 2020 Jul/Aug;12(4):341-346. Epub 2020 Jun 8.

Department of Physical Therapy, Faculty of Health Sciences, University of Malaga, Malaga, Spain.

Background: Although there is mounting evidence on sex-linked differences in paraspinal muscle function, it is unknown whether sex-based variations in mechanical and contractile characteristics of the lumbar erector spinae (LES) can be monitored noninvasively in healthy participants at rest using tensiomyography (TMG).

Hypothesis: Sex-specific effects in muscle displacement (Dm) and velocity of muscle deformation (Vd) will be observed via TMG assessed in the LES.

Study Design: Observational study. Read More

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http://dx.doi.org/10.1177/1941738120917932DOI Listing

Ultrasound-Guided Inactivation of Trigger Points Combined with Muscle Fascia Stripping by Liquid Knife in Treatment of Postherpetic Neuralgia Complicated with Abdominal Myofascial Pain Syndrome: A Prospective and Controlled Clinical Study.

Pain Res Manag 2020 17;2020:4298509. Epub 2020 May 17.

Central Laboratory, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai, Shanghai 201999, China.

Objective: To evaluate ultrasound-guided inactivation of myofascial trigger points (MTrPs) combined with abdominal muscle fascia stripping by liquid knife in the treatment of postherpetic neuralgia (PHN) complicated with abdominal myofascial pain syndrome (AMPS).

Methods: From January 2015 to July 2018, non-head-and-neck PHN patients in the Pain Department, The First Affiliated Hospital of Soochow University, were treated with routine oral drugs and weekly paraspinal nerve block for two weeks. Patients with 2 < VAS (visual analogue scale) score < 6 were subjects of the study. Read More

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http://dx.doi.org/10.1155/2020/4298509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251458PMC

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis.

Exp Ther Med 2020 Jul 23;20(1):505-511. Epub 2020 Apr 23.

Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.

The present study aimed to determine the characteristics of multifidus, erector spinae and psoas major degeneration in elderly patients with degenerative lumbar scoliosis (DLS) and the correlation between asymmetric changes and patient quality of life. A total of 49 patients with lumbar scoliosis (DLS group) and 38 healthy individuals (control group) were prospectively examined. The functional cross-sectional area, cross-sectional area difference index (CDI) and fat infiltration rate (FIR) of the multifidus, erector spinae and psoas major at the apical vertebral level were measured using MRI. Read More

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http://dx.doi.org/10.3892/etm.2020.8682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271738PMC

Randomized Trial of General Strength and Conditioning Versus Motor Control and Manual Therapy for Chronic Low Back Pain on Physical and Self-Report Outcomes.

J Clin Med 2020 Jun 3;9(6). Epub 2020 Jun 3.

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC 3220, Australia.

Exercise and spinal manipulative therapy are commonly used for the treatment of chronic low back pain (CLBP) in Australia. Reduction in pain intensity is a common outcome; however, it is only one measure of intervention efficacy in clinical practice. Therefore, we evaluated the effectiveness of two common clinical interventions on physical and self-report measures in CLBP. Read More

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http://dx.doi.org/10.3390/jcm9061726DOI Listing

Changes in spinal bone density, back muscle size, and visceral adipose tissue and their interaction following a multi-component exercise program in older men: secondary analysis of an 18-month randomized controlled trial.

Osteoporos Int 2020 Jun 4. Epub 2020 Jun 4.

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, 3128, VIC, Australia.

In middle-aged and older men, an 18-month multi-component exercise program improved spinal trabecular BMD, paraspinal, and psoas muscle cross-sectional area (CSA) but not visceral adipose tissue (VAT). However, changes in both muscle and VAT CSA were associated with changes in spinal BMD, independent of the exercise intervention.

Introduction: In older men, we previously reported that a multi-component exercise program improved lumbar spine (LS) trabecular volumetric BMD (Tb. Read More

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http://dx.doi.org/10.1007/s00198-020-05484-zDOI Listing

DPD Quantification in Cardiac Amyloidosis: A Novel Imaging Biomarker.

JACC Cardiovasc Imaging 2020 Jun;13(6):1353-1363

Barts Heart Centre, St. Bartholomew's Hospital, London, United Kingdom; Institute of Nuclear Medicine, University College London, London, United Kingdom; NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom. Electronic address:

Objectives: To assess whether single-photon emission computed tomography (SPECT/CT) quantification of bone scintigraphy would improve diagnostic accuracy and offer a means of quantifying amyloid burden.

Background: Transthyretin-related cardiac amyloidosis is common and can be diagnosed noninvasively using bone scintigraphy; interpretation, however, relies on planar images. SPECT/CT imaging offers 3-dimensional visualization. Read More

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http://dx.doi.org/10.1016/j.jcmg.2020.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264710PMC

Bone marrow fat change in pediatric patients with non-alcoholic fatty liver disease.

PLoS One 2020 2;15(6):e0234096. Epub 2020 Jun 2.

Department of Radiology, Severance Hospital, Severance Pediatric Liver Disease Research Group, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Objectives: To investigate changes of fat in bone marrow (BM) and paraspinal muscle (PSM) associated with the degree of fatty liver in pediatric patients with non-alcoholic fatty liver disease (NAFLD) in consideration of age and body mass index (BMI).

Methods: Hepatic fat, BM fat, and PSM fat from proton density fat fraction of liver MRI between June 2015 and April 2019 were quantitatively evaluated on axial images of the fat map at the mid-level of T11-L2 vertebral bodies for BM fat and at the mid-level of L2 for PSM fat. Age, height, and weight at the time of MRI were recorded and BMI was calculated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234096PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266329PMC

Therapeutic value of kinesio taping in reducing lower back pain and improving back muscle endurance in adolescents with hemophilia.

J Musculoskelet Neuronal Interact 2020 Jun;20(2):256-264

Department of Physical Therapy and Health Rehabilitation, Collage of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.

Objective: This study evaluated whether the use of kinesio taping (KT) would enhance the effect of physical therapy in relieving pain, improving muscle endurance, and boosting functional capacity in adolescents with hemophilia who experience low back pain.

Methods: Forty-five adolescents with hemophilia (age; 10-13 years) assigned randomly into three treatment arms; KT applied paraspinal alongside a physical exercise program conducted three times/week for three successive months (KT group; n=15), placebo taping plus physical exercise (Placebo group; n=15), or physical exercise only (Control group; n=15). Lower back pain, back muscle endurance, and functional capacity assessed pre- and post-treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288385PMC

Melanotic Schwannoma, a Deceptive Misnomer for a Tumor With Relative Aggressive Behavior: A Series of 7 Cranial and Spinal Cases.

Int J Surg Pathol 2020 May 26:1066896920923146. Epub 2020 May 26.

Tata Memorial Hospital and ACTREC, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

The authors present in this article a series of 7 intracranial/spinal cases of melanotic schwannomas that highlight the aggressive nature of these tumors. The series comprises 2 males and 5 females, age range 19 to 50 years, with spinal/paraspinal location in 4/7 (57%), and intracranial (along the trigeminal nerve) location in 3/7 (43%). There was no association with Carney's complex. Read More

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http://dx.doi.org/10.1177/1066896920923146DOI Listing

How to Prevent Sarcopenia Occurrence during Neoadjuvant Chemotherapy for Oesogastric Adenocarcinoma?

Nutr Cancer 2020 May 25:1-7. Epub 2020 May 25.

Department of Digestive Surgery, Strasbourg University Hospital, Strasbourg, France.

The aim of this study was to evaluate the impact of a preoperative feeding jejunostomy (FJ) on the occurrence of sarcopenia before and after preoperative chemotherapy for patients with an oesogastric adenocarcinoma (OGA). Forty-six patients with potentially resectable OGA were enrolled in a perioperative chemotherapy protocol. Sarcopenia was evaluated by measuring muscle surfaces (psoas, paraspinal and abdominal wall muscles) on abdominal CT images at the level of the 3rd lumbar vertebra. Read More

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http://dx.doi.org/10.1080/01635581.2020.1770813DOI Listing

Neurogenic Tumors of the Mediastinum.

Semin Diagn Pathol 2020 May 21. Epub 2020 May 21.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Neurogenic tumors represent a broad ill-defined category of neoplasms that includes tumors of Schwann cell and/or neuroblastic derivation, as well as neoplasms that typically develop in the central nervous system, but rarely present in ectopic sites including the mediastinum. Neurogenic tumors may occur at many different anatomic sites, but the mediastinum represents a uniquely challenging site given the complex anatomy. Additionally, some of these neoplasms may present with multicentric involvement in the context of genetic syndromes, including NF1, NF2 and schwanomatosis. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.04.004DOI Listing

Inconsistent descriptions of lumbar multifidus morphology: A scoping review.

BMC Musculoskelet Disord 2020 May 19;21(1):312. Epub 2020 May 19.

Anesthesiology Pain Center, University of Groningen, University Medical Center Groningen, Location Beatrixoord, Dilgtweg 5, Haren, the Netherlands.

Background: Lumbar multifidus (LM) is regarded as the major stabilizing muscle of the spine. The effects of exercise therapy in low back pain (LBP) are attributed to this muscle. A current literature review is warranted, however, given the complexity of LM morphology and the inconsistency of anatomical descriptions in the literature. Read More

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http://dx.doi.org/10.1186/s12891-020-03257-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236939PMC

Case report: IgG4-related renal disease co-existing with retroperitoneal fibrosis.

Transl Androl Urol 2020 Apr;9(2):794-799

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.

A 51-year-old woman visited our clinic for orthopnea, chest discomfort, and facial and leg edema. Acute kidney injury and pleural effusion were diagnosed and she received hemodialysis. This is a rare case of IgG4-related disease diagnosed by renal biopsy in the patient with retroperitoneal fibrosis and severe acute kidney injury, which progressed rapidly and required hemodialysis without markedly elevated serum IgG4 level and urinary tract obstruction. Read More

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http://dx.doi.org/10.21037/tau.2020.02.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215037PMC

Stereotactic radiosurgery for the treatment of bulky spine metastases.

J Neurooncol 2020 Jun 15;148(2):381-388. Epub 2020 May 15.

University of Virginia / Riverside, Radiosurgery Center, Newport News, VA, USA.

Introduction: Stereotactic radiosurgery (SRS) has shown durable local control for the treatment of metastatic diseasespinal metastases. Multilevel disease or epidural or paraspinal involvement present challenges to achieving local control, and this study aims to analyze treatment outcomes for such lesions.

Methods: Patients treated at a single institution with SRS to the spine from 2010-2018 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s11060-020-03534-4DOI Listing

A case of paraspinal pyomyositis in a healthy young man.

Clin Med (Lond) 2020 Mar;20(Suppl 2):s16-s17

Peterborough City Hospital, Peterborough, UK.

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http://dx.doi.org/10.7861/clinmed.20-2-s16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243551PMC
March 2020
1.685 Impact Factor

Stem Cell Clinical Trials in Spinal Cord Injury: A Brief Review of Studies in the United States.

Medicines (Basel) 2020 May 12;7(5). Epub 2020 May 12.

Department of Neurosurgery, Rush University Medical Center, Chicago, IL 60612, USA.

Background: Although many therapeutic approaches have been attempted to treat spinal cord injury, cellular transplantation offers the greatest promise in reconstituting the architecture of the damaged cord.

Methods: A literature review was conducted to search for clinical trials investigating stem cells as treatment for spinal cord injury in the United States.

Results: Overall, eight studies met inclusion criteria. Read More

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http://dx.doi.org/10.3390/medicines7050027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281746PMC

Mature Imaging-Based Outcomes Supporting Local Control for Complex Re-Irradiation Salvage Spine Stereotactic Body Radiotherapy.

Neurosurgery 2020 May 6. Epub 2020 May 6.

Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario.

Background: Upon progression after upfront radiotherapy to spinal metastases, low-dose re-irradiation conventional external beam radiation (cEBRT) provides limited clinical benefit. Spine stereotactic body radiotherapy (SBRT) allows for dose escalation in the salvage setting with the potential for improved local control.

Objective: To report mature clinical and imaging-based outcomes for salvage SBRT. Read More

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http://dx.doi.org/10.1093/neuros/nyaa109DOI Listing
May 2020
3.620 Impact Factor

Psoas muscle atrophy following unilateral hip arthroplasty.

Skeletal Radiol 2020 May 2. Epub 2020 May 2.

Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Northfield, Birmingham, UK.

Background: Studies have demonstrated the presence of muscle atrophy around the hip in patients with hip osteoarthritis. Few studies have examined the psoas muscle or assessed it at a paraspinal level in patients post-total hip arthroplasty. The aim of this study was to determine if there is significant psoas muscle atrophy as indicated by muscle cross-sectional area and high degree of fat infiltration post-unilateral hip arthroplasty. Read More

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http://dx.doi.org/10.1007/s00256-020-03447-3DOI Listing

Are We Missing the Opportunity to Measure Muscle Mass on Computed Tomography Thorax?

J Thorac Imaging 2020 Apr 28. Epub 2020 Apr 28.

All Wales Adult Cystic Fibrosis Centre, University Hospital of Llandough.

Hand grip strength (HGS) and fat free mass index (FFMI) are important indicators of skeletal muscle mass and correlate with prognosis in patients with respiratory diseases. It is also possible to estimate muscle mass by measuring muscle density and volume on cross sectional imaging. We reviewed all patients of the All Wales Cystic Fibrosis Centre who had a computed tomography thorax as part of routine clinical care between 2013 and 2017. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000517DOI Listing

Degenerate-disc infection study with contaminant control (DISC): a multicenter prospective case-control trial.

Spine J 2020 Apr 25. Epub 2020 Apr 25.

School of Medical Sciences, University of New South Wales, Sydney, Australia; Neurosurgical Research Group (NSURG), Sydney, Australia; Department of Neurosurgery, Prince of Wales Public and Private Hospitals, Suite 7, Level 7, Randwick 2031, Australia.

Background: A bacterial cause of disc degeneration has evoked several controversies and, if true, would lead to a major shift in treatment paradigm. Earlier studies analyzing the relationship of bacterial disc infection within a degenerative cohort featured prolonged cultures susceptible to contamination. The degenerate-disc infection study with contaminant control (DISC) trial aims to investigate this theory further by examining infection rates using a non-degenerative control cohort in comparison to a degenerative internal control cohort and a sham cohort (sampling only sterile paraspinal tissue). Read More

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http://dx.doi.org/10.1016/j.spinee.2020.03.013DOI Listing
April 2020
2.426 Impact Factor

A Rare Extramedullary Presentation of Multiple Myeloma: Paraspinal Muscle Involvement Revealed by FDG-PET/CT.

Turk J Haematol 2020 Apr 24. Epub 2020 Apr 24.

Ankara University Medical School Departments of Hematology, Ankara, Turkey.

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http://dx.doi.org/10.4274/tjh.galenos.2020.2020.0134DOI Listing