Search Our Scientific Publications & Authors

Neurosci Lett 2021 Jun 18:136075. Epub 2021 Jun 18.

Istanbul University- Cerrahpaşa, Cerrahpaşa School of Medicine, Department of Neurology, Istanbul, Turkey.

Objective: We aimed to investigate the brainstem circuits to reveal if there was any abnormality in these circuits in clinically diagnosed patients with NREM parasomnias during wakefulness.

Methods: Twelve patients with NREM-sleep parasomnia diagnosed according to ICSD-3 criteria and a control group of 16 healthy subjects were enrolled into our study. We analyzed the auditory startle reflex (ASR), blink reflex (BR), prepulse inhibition (PPI) of BR and recovery excitability of BR. Read More

Fortschr Neurol Psychiatr 2021 Jun 18;89(6):314-328. Epub 2021 Jun 18.

This article provides an overview of the prevalence, cause and treatment of insomnia in common neurological diseases (restless legs syndrome, stroke, multiple sclerosis, Parkinson´s disease and Alzheimer´s disease) with an additional focus on the bidirectional relationship between sleep and neurological disorders.Insomnia is prevalent, but frequently unrecognized in the context of neurological diseases. Although it is widely known that sleep has a relevant impact on quality of life in general and cerebral function in particular, sleep disorders receive little attention in the prevention and treatment of neurological diseases. Read More

J Oral Facial Pain Headache 2021 Spring;35(2):129-138

Aims: To answer the question: among observational studies, is there any association between primary headaches and bruxism in adults?

Materials And Methods: A systematic review of observational studies was performed. The search was performed in seven main databases and three gray literature databases. Studies in which samples were composed of adult patients were included. Read More

Nat Sci Sleep 2021 3;13:713-728. Epub 2021 Jun 3.

Department of Psychology, Sapienza University of Rome, Rome, Italy.

Introduction: Non-rapid eye movement (NREM) parasomnias are defined as abnormal nocturnal behaviors that typically arise from the NREM sleep stage 3 during the first sleep cycle. The polysomnographic studies showed an increase in sleep fragmentation and an atypical slow wave activity (SWA) in participants with NREM parasomnias compared to healthy controls. To date, the pathophysiology of NREM parasomnias is still poorly understood. Read More

Chronobiol Int 2021 Jun 9:1-7. Epub 2021 Jun 9.

Department of Neurology, Cukurova University Faculty of Medicine, Adana, Turkey.

Shift work is increasingly common in industrialized countries but is associated with numerous health problems, especially sleep disorders. This study compared the frequency of NREM (confusional arousal, sleep terrors, sleepwalking, sleep-related eating disorder), REM parasomnias (REM sleep behavior disorder, nightmare disorder), and isolated symptoms/normal variants (sleeptalking) between shift workers and daytime workers. A total of 1473 participants in 3 different professional groups and working different shift schedules (daytime, night, or rotating shifts) were included. Read More

Zhonghua Yi Xue Za Zhi 2021 Jun;101(21):1566-1571

Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

To evaluate the transcranial sonographic characteristics in patients with Parkinson's disease (PD) with symptoms of restless legs syndrome (RLS). Patients with diagnosis of definite PD from the Second Affiliated Hospital of Soochow University and 3 other participating hospitals between September 2018 and December 2019 were consecutively enrolled. Concurrent RLS symptoms were determined using Non-motor Symptoms Questionnaire. Read More

Nat Sci Sleep 2021 26;13:673-682. Epub 2021 May 26.

CHINTA Research Bangladesh (Centre for Health Innovation, Networking, Training, Action and Research - Bangladesh), Savar, Dhaka, Bangladesh.

Background: Sleep problems in children with Autism Spectrum Disorder (ASD) are highly prevalent, but little information is available on this issue in low- to middle-income countries (LMIC) such as Bangladesh. Therefore, the present study investigated the prevalence and socio-demographic determinants of ASD sleep disturbances in a comparison with typically developing children (TDC).

Methods: A cross-sectional interview study was carried out within a total of 446 Bangladeshi mothers, whose children's mean age was 8. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):80-91

Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, St. Petersburg, Russia.

Objective: This study aimed to assess subjective sleep and wake disorders (SWD) in patients with osteoarthritis and comorbid end-stage renal disease (ESRD) receiving hemodialysis (ESRD-HD) compared to patients with osteoarthritis and without chronic kidney disease (CKD) as well as to clarify of the association of subjective sleep characteristics with the levels of anxiety and depression and pain, general health score and laboratory parameters in these cohorts.

Material And Methods: This pilot case-control study included the patients with stage III hip osteoarthritis with ESRD-HD (=19) and without CKD (=19) aged 18-85 years. The patients received the consultations of orthopedic surgeon and internal medicine specialist with anthropometry and clinical and biochemical blood tests. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):75-79

Sechenov First Moscow State Medical University, Moscow, Russia.

Objective: To search for the association between white matter deterioration extend as well as related cognitive dysfunction and periodic limb movements in sleep (PLMS) in patients with cerebral small vessel disease (cSVD).

Material And Methods: Thirty-four subjects with cSVD were enrolled (12 men, 22 women, average age 66.9 y. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):55-60

The First Medical and Pedagogical Center «Lingua Bona», Perm, Russia.

The article presents modern ideas about the clinical features of sleep in children with attention deficit hyperactivity disorder (ADHD), the macrostructure of sleep, its cyclic organization and possible common links in the pathogenesis of sleep disorders and behavioral problems in patients. The relationship between the structure of sleep and impaired executive functions, the level of social maladjustment in patients with ADHD has been proven. Typical of children with ADHD are difficulty in going to sleep and falling asleep for a long time (resistance to sleep time), increased motor activity associated with sleep, including the association of ADHD with Restless legs syndrome (RLS) and periodic leg movement syndrome (PLMS), daytime sleepiness. Read More

Sleep Med 2021 Jul 4;83:214-221. Epub 2021 May 4.

Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8553, Japan.

Background: Sleep problems are elevated in children with attention-deficit/hyperactivity disorder (ADHD). However, until now there has been comparatively little research on the role of autistic traits in this association. The current study examined the association between ADHD symptoms and sleep problems in Japanese preschool children and whether autistic traits might also be important for this relationship. Read More

J Child Neurol 2021 May 27:8830738211015017. Epub 2021 May 27.

Grupo Mapeo Genético, Departamento de Pediatría, 27983Universidad de Antioquia UdeA, Medellín, Colombia.

Purpose: Our purpose was to describe the phenotypic features and test for association of genes , and with rolandic epilepsy in patients from Colombia.

Methods: Thirty patients were enrolled. A structured interview was applied. Read More

Healthc Technol Lett 2021 Jun 20;8(3):58-65. Epub 2021 Apr 20.

Department of Neuroscience "Rita Levi Montalcini" Università degli Studi di Torino Torino Italy.

Rapid-eye movement (REM) sleep, or paradoxical sleep, accounts for 20-25% of total night-time sleep in healthy adults and may be related, in pathological cases, to parasomnias. A large percentage of Parkinson's disease patients suffer from sleep disorders, including REM sleep behaviour disorder and hypokinesia; monitoring their sleep cycle and related activities would help to improve their quality of life. There is a need to accurately classify REM and the other stages of sleep in order to properly identify and monitor parasomnias. Read More

Ital J Pediatr 2021 May 17;47(1):113. Epub 2021 May 17.

Governor Kremers Centre, Maastricht University Medical Centre, PO Box 616 6200, MD, Maastricht, The Netherlands.

Background: Fetal alcohol spectrum disorders (FASD) is a group of conditions resulting from prenatal alcohol exposure (PAE). Patients with FASD experience a variety of neuropsychological symptoms resulting from central nervous system impairment. Little is known about sleep disorders associated with PAE. Read More

Sleep Med Clin 2021 Jun;16(2):389-408

UCLA Seizure Disorder Center, Brain Research Institute, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

Electroencephalogram (EEG) recording is essential in the evaluation of complex movement and behaviors during sleep, but in particular for differentiating epileptic versus nonepileptic events. In general, epileptiform discharges occur with greater density in the first few nonerapid eye movement cycles, and approximately 12% to 20% of seizures occur exclusively at night. This review examines the epilepsy types and syndromes whose presentation is strongly influenced by the sleep state, with an appraisal about the role that sleep plays in facilitating seizures, while deleaneatign EEG findings and clinical manifestation. Read More

Sleep Med Clin 2021 Jun 18;16(2):223-231. Epub 2021 Apr 18.

Sleep Unit, Sleep Research Institute, Calle Padre Damián 44 Madrid 28036, Spain. Electronic address:

This article is a comprehensive review of the clinical evaluation of sleep-related movement disorders. In this review, the authors present a practical approach to help clinicians identify the "pattern recognition" of movement and behavior disorders during sleep, with the process of translating a particular movement that occurs when asleep, with clinically classifying disorders, and with obtaining an etiologic diagnosis. The aim is not to provide an exhaustive review of the literature, but to concentrate on the most important symptoms, so the clinical approach can be improved and the best choices can be made during the diagnostic process. Read More

Curr Neurol Neurosci Rep 2021 05 5;21(7):30. Epub 2021 May 5.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose Of Review: We aim to summarize the sleep disorders reported in patients affected by primary mitochondrial dysfunctions and describe the association with their clinical and molecular characteristics.

Recent Findings: Sleep complaints are prevalent in mitochondrial disorders. Sleep-disordered breathing is the main sleep disorder reported in mitochondrial diseases. Read More

Sleep Med 2021 Jun 2;82:61-64. Epub 2021 Apr 2.

Sleep Medicine Unit, Neurocenter of Southern Switzerland, Ospedale Civico, Lugano, Switzerland; Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland; Department of Neurology, University Hospital, Inselspital, Bern, Switzerland.

Sleep Med X 2020 Dec 18;2:100019. Epub 2020 Jul 18.

Department of Pharmacy Practice, Texas A&M University, Irma Lerma Rangel College of Pharmacy, Houston, TX, USA.

Objective: Zolpidem is associated with sleep-related eating disorder (SRED). We compiled case reports and performed a descriptive study to identify etiology and aggravating factors.

Methods: A literature search on PubMed's MeSH search feature, CINAHL, and SciFinder was performed using search terms "Zolpidem," "Feeding and Eating Disorders/chemically induced," "Dyssomnias," "sleep eating disorder," and "sleep-related eating disorder. Read More

Anesth Analg 2021 05;132(5):1287-1295

Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.

Obstructive sleep apnea (OSA) has been shown to increase risk of adverse perioperative events. More recently, investigators have begun to examine other common sleep disorders to assess how they may be impacted by the perioperative environment, as well as influence postoperative outcomes. There are a number of mechanisms by which such common sleep disorders (eg, insomnia, restless legs syndrome, narcolepsy, and parasomnias) may have consequences in the perioperative setting, both related to the underlying pathophysiology of the diseases as well as their treatments. Read More

Cranio 2021 05;39(3):183-185

Department of Prosthodontics, Universitat Internacional de Catalunya, Barcelona,

Sleep 2021 Apr 14. Epub 2021 Apr 14.

Seattle Children's Hospital, NE Seattle, WA USA.

JAMA Netw Open 2021 Apr 1;4(4):e215713. Epub 2021 Apr 1.

Department of Nutritional Sciences, The Pennsylvania State University, University Park.

Importance: Previous studies conducted among patients with Parkinson disease (PD) reported that parasomnias other than rapid eye movement (REM) sleep behavior disorder (RBD), particularly sleepwalking (SW), are associated with PD severity. However, it remains unclear whether the presence of SW is associated with altered odds of having PD in a population-based study.

Objective: To evaluate whether probable SW, either alone or co-occurring with probable RBD, is associated with higher odds of PD in men. Read More

BMC Psychiatry 2021 04 7;21(1):180. Epub 2021 Apr 7.

Hamad Medical Corporation, Doha, Qatar.

Background: Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show partial or complete relief following movement. It can occur as a primary disorder, secondary to medical conditions or treatment with medications including but not limited to antidepressants or antipsychotics.

Case Presentation: A 32-year old man with major depressive disorder showed partial response to Escitalopram 10 mg daily. Read More

Neurotherapeutics 2021 01 5;18(1):1-5. Epub 2021 Apr 5.

Divisions of Sleep Medicine and Movement Disorders, Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA.

We find ourselves at our present crossroads with a well-traveled toolkit, perhaps too well worn but with aspirational hopes and dreams for the field of sleep neurotherapeutics. This volume is organized thematically into six topical domains that parallel the major subspecialty areas of contemporary clinical sleep neurology practice, as well as novel directions and opportunities. The issue begins with an overview of the central disorders of hypersomnolence, including narcolepsy, idiopathic hypersomnia and other hypersomnia disorders, and the related use of the entire broad range of stimulant and wake-promoting pharmacotherapies. Read More

Aging Dis 2021 Apr 1;12(2):570-585. Epub 2021 Apr 1.

2Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Stroke is a leading cause of disability and mortality all over the world. Due to an aging population, the incidence of stroke is rising significantly, which has led to devastating consequences for patients. In addition to traditional risk factors such as age, hypertension, hyperlipidemia, diabetes and atrial fibrillation, sleep disorders, as independent modifiable risk factors for stroke, have been highlighted increasingly. Read More

Front Neurosci 2021 18;15:645255. Epub 2021 Mar 18.

Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.

Nightmares are highly dysphoric dreams that are well-remembered upon awakening. Frequent nightmares have been associated with psychopathology and emotional dysregulation, yet their neural mechanisms remain largely unknown. Our neurocognitive model posits that nightmares reflect dysfunction in a limbic-prefrontal circuit comprising medial prefrontal and anterior cingulate cortices, hippocampus, and amygdala. Read More

Medicina (Kaunas) 2021 Mar 1;57(3). Epub 2021 Mar 1.

Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy.

The role of bruxism in children and adolescents with Down syndrome, the most often diagnosed congenital syndrome, is still unclear. Therefore, this study aims to conduct a narrative review of the literature about bruxism in children and adolescents with Down syndrome to identify the prevalence, risk factors, and possible treatments of this disorder. Although an accurate estimate of its prevalence could not be inferred, it appears that bruxism is more prevalent in Down syndrome individuals rather than in the general pediatric population. Read More

J Oral Rehabil 2021 Jul 2;48(7):846-871. Epub 2021 May 2.

Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus Universitet Tandlageskolen, Aarhus, Denmark.

Background: Ambulatory electromyographic (EMG) devices are increasingly being used in sleep bruxism studies. EMG signal acquisition, analysis and scoring methods vary between studies. This may impact comparability of studies and the assessment of sleep bruxism in patients. Read More