244,638 results match your criteria Parasites & Vectors [Journal]


Type I interferon responses of common carp strains with different levels of resistance to koi herpesvirus disease during infection with CyHV-3 or SVCV.

Fish Shellfish Immunol 2019 Feb 15. Epub 2019 Feb 15.

Fish Disease Research Unit, Institute for Parasitology, University of Veterinary Medicine, Hannover, Germany.

Carp from breeding strains with different genetic background present diverse levels of resistance to viral pathogens. Carp strains of Asian origin, currently being treated as Cyprinus rubrofuscus L., especially Amur wild carp (AS), were proven to be more resistant to koi herpesvirus disease (KHVD; caused by cyprinid herpesvirus 3, CyHV-3) than strains originating from Europe and belonging to Cyprinus carpio L. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.022DOI Listing
February 2019

Helminthiases; prevalence, transmission, host-parasite interactions, resistance to common synthetic drugs and treatment.

Heliyon 2019 Jan 31;5(1):e01161. Epub 2019 Jan 31.

Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Alice, 5700, South Africa.

The morbidity caused by parasite worms on susceptible hosts is of great concern and studies were carried out to explain the mechanism of infection, prevalence, host-parasite interaction and resistance of the parasite to treatment. This review elucidates the prevalence of parasitic worm infections; which is on the increases with the increase in the world population, global warming, poor standard of living particularly in troubled regions and developing nations. The neglect of the disease coupled with the resistance of these parasites to the few available drugs becomes a huge challenge that influences global disease burden. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357211PMC
January 2019

Rhoptry antigens as vaccine target.

Clin Exp Vaccine Res 2019 Jan 31;8(1):4-26. Epub 2019 Jan 31.

Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Toxoplasmosis is a cosmopolitan zoonotic infection, caused by a unicellular protozoan parasite known as that belongs to the phylum Apicomplexa. It is estimated that over one-third of the world's population has been exposed and are latently infected with the parasite. In humans, toxoplasmosis is predominantly asymptomatic in immunocompetent persons, while among immunocompromised individuals may be cause severe and progressive complications with poor prognosis. Read More

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http://dx.doi.org/10.7774/cevr.2019.8.1.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369123PMC
January 2019

Identification of phenolic compounds, antibacterial and antioxidant activities of raisin extracts.

Open Vet J 2018 26;8(4):479-484. Epub 2018 Dec 26.

Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya.

In this study, antibacterial, antioxidant and phenolic compounds of raisin extracts was evaluated. Different solvent extraction methods were utilized to extract phenolic compounds from raisin. The phenolic compounds of raisin extracts was determined using HPLC and three compounds were found, catechin, quercetin and rutin. Read More

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http://dx.doi.org/10.4314/ovj.v8i4.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356098PMC
December 2018

Recent developments in compounds acting in the DNA minor groove.

Medchemcomm 2019 Jan 12;10(1):26-40. Epub 2018 Dec 12.

School of Chemistry , Trinity Biomedical Sciences Institute , Trinity College Dublin , 152-160-Pearse Street , Dublin 2 , Ireland . Email:

The macromolecule that carries genetic information, DNA, is considered as an exceptional target for diseases depending on cellular division of malignant cells ( cancer), microbes ( bacteria) or parasites ( protozoa). To aim for a comprehensive review to cover all aspects related to DNA targeting would be an impossible task and, hence, the objective of the present review is to present, from a medicinal chemistry point of view, recent developments of compounds targeting the minor groove of DNA. Accordingly, we discuss the medicinal chemistry aspects of heterocyclic small-molecules binding the DNA minor groove, as novel anticancer, antibacterial and antiparasitic agents. Read More

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http://dx.doi.org/10.1039/c8md00425kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349057PMC
January 2019

Immunocompromised patients with pulmonary tuberculosis; a susceptible group to intestinal parasites.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S134-S139

Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical sciences, Tehran, Iran.

Aim: To investigate the presence of intestinal parasites in tuberculosis patients who suffered from immunodeficiency disorders.

Background: Tuberculosis is an important infectious disease that is endemic in some regions of Iran. However, there is a coverage in the endemicity areas of this infection with intestinal parasites. Read More

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January 2018

Improving agricultural production of domestic rabbits in Serbia by follow-up study of their parasitic infections.

Iran J Vet Res 2018 ;19(4):290-297

Department of Parasitology, Faculty of Veterinary Medicine, University of Belgrade, 11000 Beograd, Serbia.

A study was made on the prevalence of some parasitic infections appearing in domestic rabbits obtained from individual breeders in Serbia in order to improve the agricultural production of these animals. Aside from economic reasons (meat production and reproduction) rabbits are bred for the research purposes, and races are kept as household pets. For these reasons, among others, it is important to gain knowledge of medical culprits including causes of parasitic diseases that compromise their health, well-being and cause economic losses. Read More

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January 2018

Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines.

Front Immunol 2019 1;10:135. Epub 2019 Feb 1.

Institute for Glycomics, Griffith University, Southport, QLD, Australia.

In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367261PMC
February 2019

A systematic review of analgesia practices in dogs undergoing ovariohysterectomy.

Vet World 2018 Dec 25;11(12):1725-1735. Epub 2018 Dec 25.

Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi, Nairobi, Kenya.

Aim: This was a systematic review conducted to evaluate the analgesic drugs and techniques used in the management of pain in dogs undergoing ovariohysterectomy.

Materials And Methods: Systematic searches in PubMed, Google Scholar, and ScienceDirect were conducted for peer-reviewed articles written in English and published from 1995 to 2015. The key search words were dogs, ovariohysterectomy, pain, and analgesics. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1725-1735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362335PMC
December 2018

Cutaneous leishmaniasis in Qasr-e Shirin, a border area in the west of Iran.

Vet World 2018 Dec 17;11(12):1692-1697. Epub 2018 Dec 17.

Department of Medical Parasitology and Mycology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Aim: The prevalence of cutaneous leishmaniasis (CL) is growing in Iran, and new sources of the disease have been found in the country. The purpose of this study was to describe the epidemiology of CL in Qasr-e Shirin County, Kermanshah Province, West of Iran. Qasr-e Shirin is located near the Iran-Iraq border, and several million pilgrims pass through this area to Iraq every year. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1692-1697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362329PMC
December 2018

The epidemiology of tick in transmission of bacteria in buffaloes in Marshes of the south of Iraq.

Vet World 2018 Dec 16;11(12):1677-1681. Epub 2018 Dec 16.

Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.

Aim: This study aimed to investigate the role of ticks in transmission of bacteria in buffaloes in marshes of the south of Iraq.

Materials And Methods: This survey included 255 healthy and clinically ill buffaloes in marshes of the south of Iraq (Thi-Qar, Basra, and Misan provinces) between the periods from May 2017 to April 2018. Animals were clinically examined. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1677-1681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362327PMC
December 2018

Epidemiology and economic loss of fasciolosis and dicrocoeliosis in Arak, Iran.

Vet World 2018 Dec 10;11(12):1648-1655. Epub 2018 Dec 10.

Department of Medical Parasitology and Mycology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Aim: Fasciolosis and dicrocoeliosis are important parasitic diseases worldwide, causing significant financial losses due to decrease in production and viscera condemnation in animals. We performed the current research to assess the epidemiology of these infections and determine their significance from an economic perspective in Arak, Iran.

Materials And Methods: In total, we evaluated 118,463 sheep, 207,652 goats, and 43,675 cattle through necropsic analysis at the slaughterhouses. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1648-1655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362328PMC
December 2018

The adaptive proline response in P. falciparum is independent of PfeIK1 and eIF2α signaling.

ACS Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

We have previously identified the cytoplasmic prolyl tRNA synthetase in Plasmodium falciparum as the functional target of the natural product febrifugine and its synthetic analogue halofuginone (HFG), one of the most potent antimalarials discovered to date. However, our studies also discovered that short-term treatment of asexual blood stage P. falciparum with HFG analogues causes a 20-fold increase in intracellular proline, termed Adaptive Proline Response (APR), which renders parasites tolerant to HFG. Read More

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http://dx.doi.org/10.1021/acsinfecdis.8b00363DOI Listing
February 2019

Sheep tick Ixodes ricinus management on Welsh hill farms of designated conservation importance: implications for nationally declining birds.

Med Vet Entomol 2019 Feb 18. Epub 2019 Feb 18.

Mountain Lodge, Taenant, Penycae, Wrexham, U.K.

Impacts of sheep ticks Ixodes ricinus on livestock, gamebirds and wildlife are of concern across Europe. The present study describes livestock and tick management by 36 farmers from three upland sites of conservation importance in North Wales, where farmers consider that ticks have increased during the last 25 years. Sheep, average densities of 2. Read More

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http://dx.doi.org/10.1111/mve.12368DOI Listing
February 2019

Protein O- and C-Glycosylation pathways in Toxoplasma gondii and Plasmodium falciparum.

Parasitology 2019 Feb 18:1-12. Epub 2019 Feb 18.

Department of Clinical Biochemistry OE4340,Hannover Medical School,Carl-Neuberg-Strasse 1, 30625 Hannover,Germany.

Apicomplexan parasites are amongst the most prevalent and morbidity-causing pathogens worldwide. They are responsible for severe diseases in humans and livestock and are thus of great public health and economic importance. Until the sequencing of apicomplexan genomes at the beginning of this century, the occurrence of N- and O-glycoproteins in these parasites was much debated. Read More

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http://dx.doi.org/10.1017/S0031182019000040DOI Listing
February 2019

Comparison of ELISA and PCR of the 18S rRNA gene for detection of human strongyloidiasis using serum sample.

Infect Dis (Lond) 2019 Feb 18:1-8. Epub 2019 Feb 18.

c Cellular and Molecular Biology Research Center, Health Research Institute , Babol University of Medical Sciences , Babol , Iran.

Background: Strongyloides stercoralis infection is a neglected tropical disease with global distribution which is fatal in immunosuppressed patients. This study aimed to determine the prevalence of strongyloidiasis in immunocompromised individuals and cases with infectious diseases, as well as comparing ELISA and conventional PCR with coprological examination, in the central parts of Mazandaran province, northern Iran.

Methods: A single serum and a fresh stool samples were obtained from 272 and 220 patients, respectively. Read More

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http://dx.doi.org/10.1080/23744235.2019.1575978DOI Listing
February 2019

Antimicrobial, antiquorum sensing, and antiproliferative activities of sesquiterpenes from Costus speciosus rhizomes.

Pak J Pharm Sci 2019 Jan;32(1):109-115

Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia / Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Egypt.

The quorum sensing inhibitory (QSI) and antimicrobial potentials of the total methanol extract (TME) and different extractives as well as the sesquiterpenes: dehydrodihydrocostus lactone (1), dehydrocostus lactone (2), arbusculin A (3), santamarine (4), reynosin (5), and specioic acid (6) isolated from Costus speciosus rhizomes were evaluated. The CHCl3:EtOAc (1:1), EtOAc, and TME fractions exhibited potent antibacterial activity toward B. cereus with inhibition zone diameter 13 mm. Read More

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January 2019

Cross-talk between the Ras GTPase and the Hog1 survival pathways in response to nitrosative stress in Paracoccidioides brasiliensis.

Nitric Oxide 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmaceutical Sciences, Universidade Federal de São Paulo, Campus Diadema, SP, Brazil; Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, SP, Brazil. Electronic address:

Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that cause paracoccidioidomycosis (PCM), the major systemic mycosis in Latin America. The capacity to evade the innate immune response of the host is due to P. brasiliensis ability to respond and to survive the nitrosative stress caused by phagocytic cells. Read More

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http://dx.doi.org/10.1016/j.niox.2019.02.002DOI Listing
February 2019

Cloning, expression and purification of 3'-nucleotidase/nuclease, an enzyme responsible for the Leishmania escape from neutrophil extracellular traps.

Mol Biochem Parasitol 2019 Feb 14. Epub 2019 Feb 14.

Instituto de Bioquímica Médica Leopoldo de Meis (IBqM), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address:

Leishmaniasis is one of the most significant of the neglected tropical diseases, with 350 million people in 98 countries worldwide living at risk of developing one of the many forms of the disease. During the transmission of the parasite from its vector to the vertebrate host, neutrophils are rapidly recruited to the site of the sandfly bite. Using different strategies, neutrophils can often kill a large number of parasites. Read More

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http://dx.doi.org/10.1016/j.molbiopara.2019.02.004DOI Listing
February 2019

The paramagnetic properties of malaria pigment, hemozoin, yield clues to a low-cost system for its trapping and determination.

Talanta 2019 May 25;197:553-557. Epub 2019 Jan 25.

Service de Chimie Thérapeutique et de Pharmacognosie, Université de Mons (UMONS), Bât. 6, Chemin du Champ de Mars 25, 7000 Mons, Belgium. Electronic address:

The binding of malaria pigment, hemozoin, by a gradient magnetic field has been investigated in a manual trapping column system. Two types of magnetic filling have been tested to produce field gradients: nickel-plated steel wires, wrapped around a steel core, and superparamagnetic microbeads. The latter system allows an efficient trapping (> 80%) of β-hematin (a synthetic pigment with physical and paramagnetic properties analogous to those of hemozoin). Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.090DOI Listing

Velogenic newcastle disease virus tissue tropism and pathogenesis of infection in chickens by application of in situ PCR, immunoperoxase staining and HE staining.

Microb Pathog 2019 Feb 13. Epub 2019 Feb 13.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Limited deep studies are available in the field of early stages of pathogenesis of Newcastle disease virus (NDV) infection and tissue tropism of NDV. In this study, 24 specific pathogen free (SPF) chickens of white leghorn breed were infected with Newcastle disease (ND) by intranasal administration of 10⁵ 50% EID50/0.1 mL of velogenic NDV (vNDV). Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.017DOI Listing
February 2019

Progenesis and facultative life cycle abbreviation in trematode parasites: are there more constraints than costs?

Int J Parasitol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Sciences, University of Alberta, Edmonton T6G 2E9, Alberta, Canada. Electronic address:

Complex life cycles provide advantages to parasites (longer life span, higher fecundity, etc.), but also represent a series of unlikely events for which many adaptations have evolved (asexual multiplication, host finding mechanisms, etc.). Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.11.009DOI Listing
February 2019

Somatic proteome of Haemonchus contortus.

Int J Parasitol 2019 Feb 13. Epub 2019 Feb 13.

Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

Currently, there is a dearth of proteomic data to underpin fundamental investigations of parasites and parasitism at the molecular level. Here, using a high throughput LC-MS/MS-based approach, we undertook the first reported comprehensive, large-scale proteomic investigation of the barber's pole worm (Haemonchus contortus) - one of the most important parasitic nematodes of livestock animals worldwide. In total, 2487 unique H. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.12.003DOI Listing
February 2019

Ticks (Acari: Ixodida) on birds (Aves) migrating through the Polish Baltic coast.

Exp Appl Acarol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Biological Sciences, University of Zielona Góra, Prof. Z. Szafrana Str. 1, 65-516, Zielona Góra, Poland.

Seasonal bird (Aves) migration between breeding and wintering areas, often located on different continents, can facilitate the spreading of tick species (Acari: Ixodida) and of tick-borne pathogens. The aim of the study was to analyse the occurrence of ticks dispersed by birds migrating along the Polish Baltic coast during spring and autumn migration. Field research was conducted at the bird ringing station in Wicie, located on the middle of the Polish Baltic coast, in 2011 and 2012 during spring and autumn migration. Read More

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http://dx.doi.org/10.1007/s10493-019-00341-zDOI Listing
February 2019

scFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor.

Gene Ther 2019 Feb 15. Epub 2019 Feb 15.

Research Center for Gene Therapy, Escola Paulista de Medicina, Universidade Federal de São Paulo Rua Mirassol, 207 CEP 04044-010, São Paulo, SP, Brazil.

The carcinoembryonic antigen (CEA) is the main tumor-associated antigen of colorectal cancers. Previously, we developed a DNA vaccine using scFv6.C4, a CEA surrogate, against CEA-expressing tumors; 40% of the vaccinated mice were tumor-free after tumor challenge. Read More

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http://dx.doi.org/10.1038/s41434-019-0062-yDOI Listing
February 2019

Molecular epidemiology of acute HCV infection in HIV-positive patients from Hong Kong, Taipei, Tokyo.

Liver Int 2019 Feb 16. Epub 2019 Feb 16.

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Acute hepatitis C virus (HCV) infections have been increasingly reported among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in the Asia-Pacific region. It remains unknown whether international network of HCV transmission has occurred in this region.

Methods: HIV-positive patients with acute HCV infection, defined as HCV seroconversion within a year or documented acute hepatitis with seroconversion, diagnosed in Hong Kong, Taipei, and Tokyo during 2010-2016 were included in this molecular epidemiology study. Read More

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http://doi.wiley.com/10.1111/liv.14073
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http://dx.doi.org/10.1111/liv.14073DOI Listing
February 2019
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A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.

Immunity 2019 Feb 6. Epub 2019 Feb 6.

Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK. Electronic address:

The epidermal growth factor receptor ligand Amphiregulin has a well-documented role in the restoration of tissue homeostasis after injury; however, the mechanism by which Amphiregulin contributes to wound repair remains unknown. Here we show that Amphiregulin functioned by releasing bioactive transforming growth factor beta (TGF-β) from latent complexes via integrin-α activation. Using acute injury models in two different tissues, we found that by inducing TGF-β activation on mesenchymal stromal cells (pericytes), Amphiregulin induced their differentiation into myofibroblasts, thereby selectively contributing to the restoration of vascular barrier function within injured tissue. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.008DOI Listing
February 2019

Comparison between Echinococcus granulosus sensu stricto (G1) and E. canadensis (G6) mitochondrial genes (cox1 and nad1) and their related protein models using experimental and bioinformatics analysis.

Comput Biol Chem 2019 Feb 5;79:103-109. Epub 2019 Feb 5.

Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Cystic echinococcosis (CE) as a zoonotic parasitic disease, remains a health challenge in many parts of the world. There are different species of Echinococcus granulosus sensu lato with different pathogenicity and host preferences.Different procedures have been applied for characterization of Echinococcus taxa in which two mitochondrial genes, cox1 and nad1 have been used more common. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.02.002DOI Listing
February 2019

The expansion of circulating IL-6 and IL-17-secreting follicular helper T cells is associated with neurological disabilities in neuromyelitis optica spectrum disorders.

J Neuroimmunol 2019 Jan 25;330:12-18. Epub 2019 Jan 25.

Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Microbiology, Immunology and Parasitology, Rio de Janeiro State University, Rio de Janeiro, Brazil; Departament of Neurology, Federal University of the State of Rio de Janeiro, Brazil. Electronic address:

Due to their function in assisting B cells, T cells may be involved in the production of pathogenic IgG in neuromyelitis optica spectrum disorder (NMOSD). In the present study, the proportion of IL-6 and IL-17 T cell subsets was higher in NMOSD patients than healthy individuals. The frequency of both T cell subsets were directly associated with disease activity. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.015DOI Listing
January 2019

In vitro anthelmintic effect of biologically synthesized silver nanoparticles on liver amphistome, Gigantocotyle explanatum.

Exp Parasitol 2019 Feb 12. Epub 2019 Feb 12.

Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, India.

In order to ensure global food security a rationale approach is required to control all those factors which directly or indirectly affect the food productivity. The neglected helminthic diseases alone are responsible for huge economic losses to the agrarian stakeholders. The problem is further compounded by the emerging drug resistance in flukes against the commonly used anthelmintics like triclabendazole. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.02.005DOI Listing
February 2019

Diagnostic performance of CellaVision DM96 for Plasmodium vivax and Plasmodium falciparum screening in peripheral blood smears.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Department of Laboratory Medicine, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Microscopic examination of blood smears is the standard method for malaria diagnosis but is labor-intensive and requires expert staff. CellaVision DM96 (CellaVision, Lund, Sweden) is a digital hematology analyzer available for advanced morphological analysis of blood films including intracellular parasites. Here, we evaluated the CellaVision DM96 Advanced RBC Application for malaria detection in stained peripheral blood (PB) smears. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183084
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http://dx.doi.org/10.1016/j.actatropica.2019.02.009DOI Listing
February 2019
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FLEAS ASSOCIATED WITH SIGMODONTINE RODENTS AND MARSUPIALS FROM THE PARANAENSE FOREST IN NORTHEASTERN ARGENTINA.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Centro de Estudios Parasitológicos y de Vectores (CEPAVE) (CONICET CCT La Plata-UNLP), Boulevard 120 s/n e/60 y 64, 1900, La Plata, Argentina. Electronic address:

Fleas from the Paranaense Forest in northeastern Argentina are studied. Herein we provided a list of specimens identified, which includes host species and geographical distribution for each taxa, as well as some comments on the morphology, distribution and epidemiological importance when available. The following eight species and subspecies of fleas belonging to four families were identified: Ctenocephalides felis felis (Pulicidae), Craneopsylla minerva minerva (Stephanocircidae), Polygenis (Polygenis) platensis, Polygenis (Polygenis) roberti beebei, Polygenis (Neopolygenis) pradoi, Polygenis (Neopolygenis) pygaerus (Rhopalopsyllidae), Adoratopsylla (Adoratopsylla) antiquorum antiquorum, and Adoratopsylla (Tritopsylla) intermedia intermedia (Ctenophthalmidae). Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.011DOI Listing
February 2019

Parasites of Gymnodactylus darwinii Gray, 1845 (Squamata, Phyllodactylidae) from an Atlantic Rainforest fragment.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Programa de Pós-Graduação em Ecologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Programa de Pós-Graduação em Ciência Animal Tropical, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Laboratório de Parasitologia (LAPAR), Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil. Electronic address:

Gymnodactylus darwinii is an endemic lizard from Atlantic Rainforest. Ecological aspects of your parasitic fauna are still unknown. Therefore, the goal of the present study was to know the composition of parasitic fauna of G. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.010DOI Listing
February 2019

Structured mathematical models to investigate the interactions between Plasmodium falciparum malaria parasites and host immune response.

Math Biosci 2019 Feb 12. Epub 2019 Feb 12.

Department of Mathematics, Millersville University of Pennsylvania, Millersville, PA 17551, USA. Electronic address:

Malaria infection has posed a major health threat for hundreds of years in human history. Yet, due to the complex interactions between a host immune response and the parasite, no sophisticated mathematical models exist to study its dynamics. In this work, we propose a new system of structured partial differential equations that account for the dependence of red blood cell infectivity on maturation level. Read More

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http://dx.doi.org/10.1016/j.mbs.2019.02.005DOI Listing
February 2019

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria.

PLoS Negl Trop Dis 2019 Feb 15;13(2):e0006987. Epub 2019 Feb 15.

Department of Medical Biology, University of Melbourne, Melbourne, Australia.

Background: The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of naturally acquired immunity. However, region II of PvDBP, which contains the receptor-binding site, is highly polymorphic. The natural acquisition of antibodies to different variants of PvDBP region II (PvDBPII), including the AH, O, P and Sal1 alleles, the central region III-V (PvDBPIII-V), and P. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006987DOI Listing
February 2019

The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial.

PLoS Med 2019 Feb 15;16(2):e1002745. Epub 2019 Feb 15.

Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao People's Democratic Republic, where artemisinin resistance is prevalent. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002745DOI Listing
February 2019

Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.

Malar J 2019 Feb 15;18(1):38. Epub 2019 Feb 15.

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

Background: Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and cutting edge technologies. In addition, and in accordance with the three R's of animal use in research, in vivo studies should be constantly refined to avoid unnecessary pain and distress to the experimental animals by using preemptive euthanasia as soon as the main scientific study objective has been accomplished. Read More

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http://dx.doi.org/10.1186/s12936-019-2661-xDOI Listing
February 2019

Preconceptional factors associated with hemoglobin concentration in early pregnancy: a community-based cohort study in rural northeastern Tanzania.

Trop Med Int Health 2019 Feb 15. Epub 2019 Feb 15.

Division of Global Health, Department of Public Health, University of Copenhagen, Denmark.

Objective: Maternal anemia in early pregnancy is associated with poor pregnancy outcomes. Furthermore, preconceptional health can influence the health during pregnancy. The aim of this study was to investigate which preconceptional factors were associated with Hb concentration in early pregnancy. Read More

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http://dx.doi.org/10.1111/tmi.13219DOI Listing
February 2019

The use of Laser-based Diagnostics for the Rapid Identification of Infectious Agents in Human Blood.

J Appl Microbiol 2019 Feb 15. Epub 2019 Feb 15.

Food and Drug Administration, Center for Biologics Evaluation and Research, 10903 New Hampshire Ave, Building 72, Room 4328, Silver Spring, Maryland, 20993.

Aims: To investigate the use of a laser-based method of detection as a potential diagnostic test for the rapid identification of infectious agents in human blood.

Methods And Results: In this study, the successful differentiation of blood spiked with viruses, bacteria, or protozoan parasites to clinically relevant levels is demonstrated using six blood types (O+, O-, AB+, A+, A-, B+) using blood from different individuals with blood samples prepared in two different laboratories. Experiments were performed using various compositions of filters, experimental set-ups, and experimental parameters for spectral capture. Read More

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http://dx.doi.org/10.1111/jam.14222DOI Listing
February 2019

Parasite loss or parasite gain? Story of nematodes in antipodean waters.

Authors:
Shokoofeh Shamsi

Parasite Epidemiol Control 2019 Feb 25;4:e00087. Epub 2019 Jan 25.

School of Animal and Veterinary Sciences, Graham Centre for Agricultural Innovations, Charles Sturt University, Australia.

spp. are parasitic nematodes belonging to the family Anisakidae. They are known to be able to have highly pathogenic impacts on both wildlife (fish, birds, marine mammals) and humans. Read More

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http://dx.doi.org/10.1016/j.parepi.2019.e00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360457PMC
February 2019

Prevalence and co-infection with tick-borne and spp. in red deer () and roe deer () in Southern Norway.

Int J Parasitol Parasites Wildl 2019 Apr 14;8:127-134. Epub 2019 Jan 14.

Department of Biology, Vytautas Magnus University, Vileikos 8, LT -444404, Kaunas, Lithuania.

and spp. are causative agents of tick-borne infections that are increasingly considered as a threat to animal and public health. To assess the role of cervids in the maintenance of zoonotic pathogens in Norway, we investigated the prevalence of and spp. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360459PMC

Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine.

Curr Ther Res Clin Exp 2019 12;90:9-15. Epub 2019 Jan 12.

Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology University of Copenhagen and Department of Clinical Microbiology and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

Background: There is limited information on the safety or efficacy of currently recommended antimalarial drugs in patients with sickle cell disease (SCD), a population predisposed to worse outcomes if affected by acute malaria. Artesunate-amodiaquine (ASAQ) is the first-line treatment for uncomplicated malaria (UM) in many malaria-endemic countries and is also used for treatment of UM in SCD patients. There is, however, no information to date, on the pharmacokinetics (PK) of amodiaquine or artesunate or the metabolites of these drugs in SCD patients. Read More

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http://dx.doi.org/10.1016/j.curtheres.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360331PMC
January 2019

Genetic diversity of hepatitis B co-infection with hepatitis C, D and E viruses among Malaysian chronic hepatitis B patients.

Afr Health Sci 2018 Dec;18(4):1117-1133

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University Putra Malaysia.

Background: Hepatitis B virus co-infection with other strains of viral hepatitis is associated with increased risk of liver cirrhosis and hepatic decompensation.

Objectives: This is a prevalence study that assessed the genetic diversity of chronic hepatitis B patients and coinfection.

Methods: Chronic hepatitis B patients enrolled in this study were tested for antibodies of other hepatitis viruses using ELISA kits. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354894PMC
December 2018

Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot () Enteromyxosis.

Front Genet 2019 31;10:26. Epub 2019 Jan 31.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Lugo, Spain.

Enteromyxosis, caused by , is one of the most devastating diseases stemming from myxozoan parasites in turbot ( L.), being a limiting factor for its production. The disease develops as a cachectic syndrome, associated to catarrhal enteritis and leukocytic depletion, with morbidity and mortality rates usually reaching 100%. Read More

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http://dx.doi.org/10.3389/fgene.2019.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365611PMC
January 2019

Different Life Cycle Stages of Induce Contrasting Responses in Dendritic Cells.

Front Immunol 2019 31;10:32. Epub 2019 Jan 31.

Burnet Institute, Melbourne, VIC, Australia.

Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by blood-stage parasites will help to understand how immunity is acquired and maintained, and how vaccine responses may be impacted by malaria infection or exposure. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00032
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http://dx.doi.org/10.3389/fimmu.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365426PMC
January 2019
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β-Actin: Not a Suitable Internal Control of Hepatic Fibrosis Caused by .

Front Microbiol 2019 31;10:66. Epub 2019 Jan 31.

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Schistosomiasis japonica is a significant health problem that leads to morbidity and mortality of humans. It is characterized by hepatic granulomatous response and fibrosis caused by eggs deposition in the liver. β-actin, a traditional housekeeping gene, is widely used as an internal control to normalize gene and protein expression. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365423PMC
January 2019

Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors.

Sci Rep 2019 Feb 14;9(1):2117. Epub 2019 Feb 14.

Department of Parasitology, Faculty of Biology, University of Warsaw, 1 Miecznikowa Street, 02-096, Warsaw, Poland.

The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland (B. burgdorferi s.l. Read More

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http://dx.doi.org/10.1038/s41598-019-38755-9DOI Listing
February 2019

Nematicidal and insecticidal activities of halogenated indoles.

Sci Rep 2019 Feb 14;9(1):2010. Epub 2019 Feb 14.

School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.

Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies and structure-activity relationship analysis. Read More

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http://dx.doi.org/10.1038/s41598-019-38561-3DOI Listing
February 2019

Juvenile hormone controls ovarian development in female Anopheles albimanus mosquitoes.

Sci Rep 2019 Feb 14;9(1):2127. Epub 2019 Feb 14.

Department of Biological Sciences and Biomolecular Science Institute, Florida International University, Miami, FL, USA.

Anophelinae mosquitoes are vectors of human malaria, a disease that infects hundreds of millions of people and causes almost 600,000 fatalities annually. Despite their medical importance, laboratory studies on key aspects of Anophelinae reproductive biology have been limited, and in particular, relatively little is known about the role of juvenile hormone (JH) in the control of female reproduction. The study presented here attempts to fill a gap of knowledge in our understanding of the JH control of ovarian development in female Anophelinae mosquitoes, using Anopheles albimanus as a model. Read More

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http://dx.doi.org/10.1038/s41598-019-38631-6DOI Listing
February 2019

Genome defense against integrated organellar DNA fragments from plastids into plant nuclear genomes through DNA methylation.

Sci Rep 2019 Feb 14;9(1):2060. Epub 2019 Feb 14.

Faculty of Life Science, Kyoto Sangyo University, Kyoto, Kyoto, Japan.

Nuclear genomes are always faced with the modification of themselves by insertions and integrations of foreign DNAs and intrinsic parasites such as transposable elements. There is also substantial number of integrations from symbiotic organellar genomes to their host nuclear genomes. Such integration might have acted as a beneficial mutation during the evolution of symbiosis, while most of them have more or less deleterious effects on the stability of current genomes. Read More

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http://dx.doi.org/10.1038/s41598-019-38607-6DOI Listing
February 2019