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    Skin Microbiome in Small- and Large-plaque Parapsoriasis.
    Acta Derm Venereol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Dermatology and Allergology, University of Helsinki, and Helinki University Hospital, FIN-00250 Helsinki, Finland.
    Staphylococcal enterotoxins have been shown to promote lymphoma-associated immune dysregulation. This study examined changes in the skin microbiome of parapsoriasis compared with intact skin. Swab microbiome specimens were taken of the parapsoriasis lesions of 13 patients. Read More

    [Febrile ulceronecrotic Mucha-Habermann disease].
    Rev Med Chil 2016 Sep;144(9):1214-1217
    Anatomía Patológica, Hospital Clínico San Borja Arriarán, Universidad de Chile, Santiago, Chile.
    Pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic Mucha-Habermann disease (FUMHD) are considered different manifestations of the same disease. Febrile ulceronecrotic Mucha-Habermann disease is a rare, and potentially lethal illness which is characterized by fast progression of numerous papules that converge, ulcerate and form a plaque with a necrotic center, together with hemorrhagic vesicles and pustules that are associated with high fever and variable systemic symptoms. We report a 16 years old male presenting with erythematous papules with crusts and fever. Read More

    Past, present and future of cutaneous lymphomas.
    Semin Diagn Pathol 2017 Jan 28;34(1):3-14. Epub 2016 Nov 28.
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria. Electronic address:
    Primary cutaneous lymphomas represent a broad group of diseases with different clinical, histopathological, phenotypic, molecular, and prognostic features. All cutaneous lymphomas share the same tropism of neoplastic lymphocytes for the skin, but precise classification is paramount for proper management of the patients. Primary cutaneous lymphomas are classified according to the schemes proposed by the European Organization for Research and Treatment of Cancer (EORTC)-Cutaneous Lymphomas Task Force together with the World Health Organization (WHO) in 2005, and the WHO classification of 2008 with the 2016 update. Read More

    Phototherapy in children: Considerations and indications.
    Clin Dermatol 2016 Sep-Oct;34(5):633-9. Epub 2016 May 24.
    Harvard Medical School, Dermatology Program, Division of Allergy and Immunology, Department of Medicine, Boston Children's Hospital, Boston, MA. Electronic address:
    Phototherapy can be a safe and effective treatment for various skin diseases in children. Special considerations governing the use of this treatment modality in pediatric populations include patient, family, and facility-based factors that are oriented around heightened concerns with regard to safety and tolerability of treatment. Although phototherapy has been found to be effective in a wide range of dermatologic conditions affecting pediatric populations, including psoriasis, atopic dermatitis, pityriasis lichenoides, cutaneous T-cell lymphoma, and vitiligo, there is need for additional research on other conditions in which phototherapy has shown promise. Read More

    Successful treatment of pityriasis lichenoides chronica with narrow-band ultraviolet B therapy in a patient with Keratitis-Ichthyosis-Deafness syndrome: a case report.
    Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.
    Marmara University, School of Medicine, Department of Dermatology, Istanbul.
    Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis causing ichthyosis-like skin lesions, keratitis, and deafness. Herein, we report a patient with this rare syndrome in association with pityriasis lichenoides chronica, which was succesfully treated with narrow-band ultraviolet B phototherapy despite our concerns regarding the increased risk of squamous cell carcinoma, hyperpyrexia, and keratitis. Read More

    Granulomatous slack skin - seven years follow-up of a case with features of "parapsoriasis en plaques", muscle involvement, granulomatous vasculitis, and necrobiotic changes.
    Rom J Morphol Embryol 2016 ;57(2):539-46
    Department of Dermatology, "Carol Davila" Central University Emergency Military Hospital, Bucharest, Romania;
    Granulomatous slack skin (GSS) represents an extremely rare variant of mycosis fungoides with only 70 cases reported in the literature to date. It is characterized clinically by the occurrence of bulky, pendulous skinfolds, usually located in flexural areas and histologically by an infiltrate composed of small neoplastic T-lymphocytes joined by granulomatous inflammation with scattered multinucleated giant cells containing nuclei arranged in a wreath-like fashion. Since its first description, very rare cases of GSS with muscle involvement, large vessels involvement, or necrobiotic changes have been reported. Read More

    Phototherapy for Pityriasis Lichenoides in the Pediatric Population: A Review of the Published Literature.
    Am J Clin Dermatol 2016 Dec;17(6):583-591
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
    Background: Pityriasis lichenoides (PL) is a dermatologic disorder that manifests in either the acute (pityriasis lichenoides et varioliformis acuta) or the chronic form (pityriasis lichenoides chronica, also known as parapsoriasis chronica). Traditional first-line therapy consists of corticosteroids or antibiotics; however, these treatments are often accompanied with multiple side effects and may be ineffective.

    Objective: The goal of this study was to review the use of phototherapy for treating PL in the pediatric population. Read More

    TOX expression and role in CTCL.
    J Eur Acad Dermatol Venereol 2016 Sep 26;30(9):1497-502. Epub 2016 Jun 26.
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
    Background: Cutaneous T-cell lymphomas (CTCL) are skin malignancies including mycosis fungoides (MF) and CD30(+) lymphoproliferative disorders (LPD). In early disease, CTCL can be difficult to diagnose, especially in MF for which there is no reliable diagnostic marker. MF/CTCL have increased expression of thymocyte selection-associated HMG box protein (TOX). Read More

    Pityriasis lichenoides chronica presenting with bilateral palmoplantar involvement.
    Cutis 2016 May;97(5):345;347;358
    Bay Dermatology/Largo Medical Center, Florida, USA.
    Pityriasis lichenoides is an uncommon, acquired, idiopathic, self-limiting skin disease that poses a challenge to patients and clinicians to diagnose and treat. Several variants exist including pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulcer-onecrotic Mucha-Habermann disease. Precise classification can be difficult due to an overlap of clinical and histologic features. Read More

    Tailor systemic therapy to the patient with severe psoriasis.
    Practitioner 2016 Feb;260(1790):23-6, 3
    There is no standard definition regarding the severity of psoriasis, and a number of factors should be considered, including the extent and stability of skin disease, involvement of joints, response to treatment, and impact on quality of life. Erythrodermic psoriasis and pustular psoriasis are severe conditions and the patient may be systemically unwell and febrile. NICE recommends that four key areas should be evaluated and recorded when assessing patients: severity, using the static Physician's Global Assessment (sPGA); disease impact on physical, psychological and social wellbeing using the Dermatology Life Quality Index (DLQI); the presence of psoriatic arthritis; and comorbidities. Read More

    Lymphomatoid contact dermatitis associated with textile dye at an unusual location.
    Indian Dermatol Online J 2015 Dec;6(Suppl 1):S24-6
    Department of Dermatology, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
    Lymphomatoid contact dermatitis (LCD) is a rare variant of noneczematous allergic contact dermatitis, which can mimick parapsoriasis or early-stage mycosis fungoides with its atypical clinical and histopathological manifestation. Many different haptens have been reported to be associated with this reaction. Histopathological examination, immunhistochemistry, clonality tests, and patch tests are mandatory for diagnosis and differential diagnosis. Read More

    Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides.
    J Immunol Res 2015 16;2015:856340. Epub 2015 Dec 16.
    Uludag University School of Medicine, Department of Dermatology and Venereology, Bursa, Turkey.
    We retrospectively analyzed the clinicopathological correlation and prognostic value of cell surface antigens expressed by peripheral blood mononuclear cells in patients with mycosis fungoides (MF). 121 consecutive MF patients were included in this study. All patients had peripheral blood flow cytometry as part of their first visit. Read More

    Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases.
    Acta Derm Venereol 2016 Jun;96(5):669-73
    Section of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Skåne University Hospital, SE-221 85 Lund, Sweden.
    Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from 1996 to 2010. Read More

    Febrile Ulceronecrotic Mucha-Habermann Disease: Two Cases with Excellent Response to Methotrexate.
    Pediatr Dermatol 2015 Nov-Dec;32(6):e307-8. Epub 2015 Oct 8.
    Department of Dermatology, Center for Health and Healing, Oregon Health and Science University, Portland, Oregon.
    Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a severe form of pityriasis lichenoides et varioliformis acuta (PLEVA), featuring large, ulcerative, necrotic skin plaques, high fever, and other systemic symptoms, is a rare disorder of unknown etiology. No randomized controlled trials have established treatment guidelines and multiple modalities are often employed, making it difficult to assess the efficacy of any single agent. We report two cases of this condition in which treatment with methotrexate plus antibiotic treatment for superinfection led to rapid improvement. Read More

    Risk of Acute Myocardial Infarction or Stroke in Patients with Mycosis Fungoides and Parapsoriasis.
    Acta Derm Venereol 2016 May;96(4):530-4
    Department of Dermatology, Aarhus University Hospital, P.P. Oerumsgade 11, DK-8000 Aarhus, Denmark.
    Mycosis fungoides (MF) and parapsoriasis display increased inflammation, which may be associated with increased risk of arterial cardiovascular events. The aim of this Danish nationwide population-based cohort study was to assess the relative risk (RR) of acute myocardial infarction (AMI) or stroke in patients with MF and parapsoriasis. In patients with MF, the RR of AMI or stroke was 1. Read More

    [Febrile ulceronecrotic Mucha-Habermann disease].
    Arch Pediatr 2016 Jan 6;23(1):82-5. Epub 2015 Nov 6.
    Service de pédiatrie générale, CHU Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address:
    Pityriasis lichenoides et varioliformis acuta (PLEVA) is an inflammatory skin disease that is unknown to pediatricians. The ulceronecrotic febrile form is a rare and potentially lethal variant. We report the case of a 7-year-old boy with a papulovesicular eruption lasting for 4 weeks, secondarily associated with ulcers and necrotic crusts, fever, and systemic signs. Read More

    Lichen striatus and pityriasis lichenoides chronica in an 11-year-old girl: An etiologic relationship?
    J Pak Med Assoc 2015 Sep;65(9):1011-3
    Department of Pathology, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey.
    Lichen striatusis a rare linear papulardermatosis that primarily occurs in children. The lesions have a linear distribution following Blaschko's lines. Pityriasis lichenoides is an uncommon benign skin disorder with two major variants: acute and chronic. Read More

    Systemic involvement in mycosis fungoides.
    Clin Dermatol 2015 Sep-Oct;33(5):563-71. Epub 2015 Jun 1.
    Department of Dermatology, University of Zurich, Switzerland. Electronic address:
    Mycosis fungoides (MF) represents almost 50% of all primary cutaneous lymphomas and more than 70% of cutaneous T-cell lymphomas (CTCL). Arising from preferentially skin-homing lymphocytes with genetic instability, MF evolves through stages (IA-IVB), producing inconspicuous inflammatory features in the beginning and finally resulting in a proliferation of cytomorphologic, phenotypic, and genotypic abnormal tumor cells. Over the past 200 years, there has been much confusion in the classification of lymphomas due to semantic disagreements (MF, CTCL, parapsoriasis, lymphosarcoma, reticulum cell sarcoma, and many other terms), lack of diagnostic standard criteria, and new molecular diagnostic methods. Read More

    Pityriasis lichenoides et varioliformis acuta after influenza vaccine.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):181-4
    Hospital da Polícia Militar de Minas Gerais, Belo Horizonte, MG, BR.
    The etiology of pityriasis lichenoides is unknown. One of the accepted theories admits that PL is an inflammatory response to extrinsic antigens such as infectious agents, drugs and vaccines. In recent medical literature, only the MMR vaccine (Measles, Mumps and Rubella) was associated with the occurrence of this disease. Read More

    Multiple minute digitate hyperkeratosis--a peculiar entity.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):153-5
    Centro Hospitalar Universitário de Coimbra, Coimbra, PT.
    Multiple minute digitate hyperkeratosis is a rare, non-follicular dermatosis, with fewer than 30 cases described worldwide. It can be either acquired or inherited in an autosomal dominant pattern. We describe the case of an 83-year old patient with life-long, multiple, digitate, milimetric lesions, and a positive family history for the same dermatosis. Read More

    Frequency of hypopigmented mycosis fungoides in Egyptian patients presenting with hypopigmented lesions of the trunk.
    Am J Dermatopathol 2015 Nov;37(11):834-40
    *Dermatopathology Unit, Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt; Departments of †Pathology, and ‡Dermatology, National Research Centre, Cairo, Egypt.
    Hypopigmented mycosis fungoides (HMF) is an uncommon variant of mycosis fungoides with an unknown exact frequency. We aimed to study the frequency of HMF in a cohort of Egyptian patients presenting to a tertiary care center in Cairo, Egypt, with hypopigmented lesions of the trunk. Hundred patients with hypopigmented lesions involving the trunk (with or without other sites involvement) were subjected to thorough clinical and histopathological examination. Read More

    An observational study of cutaneous adverse drug reactions in a teaching hospital.
    Int J Clin Pharm 2015 Dec 4;37(6):996-9. Epub 2015 Aug 4.
    Department of Medicine and Preventive Cardiology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, 110062, India.
    Background: Pharmacotherapy is often impeded by adverse drug reactions (ADRs). Among these ADRs cutaneous reactions are the major class being easily identified and reported. If not noted early it has potential to develop into serious lesions. Read More

    [Pityriasis Lichenoides: Case report and review of the literature].
    Rev Chil Pediatr 2015 Mar-Apr;86(2):121-5
    Residente de Dermatología, P. Universidad Católica de Chile.
    Introduction: Pityriasis lichenoides is a benign inflammatory disease of unknown etiology. There are two types of this condition: an acute form (PLEVA = pityriasis lichenoides et varioliformis acuta) and a chronic one (PLC = pityriasis lichenoid chronica). Both are more common in children and young adults. Read More

    Hypertrophic Lichenoid Eruption in a Child Successfully Treated Using Acitretin and Surgery: A Case Report and Literature Review.
    Pediatr Dermatol 2015 Nov-Dec;32(6):e238-41. Epub 2015 Jul 29.
    Department of Dermatology, Northwest Hospital, Xi'an Jiaotong University, Xi'an Shaanxi, China.
    A 9-year-old boy presented with a history of keratotic violaceous plaques on the limbs and face for 8 years that had gradually progressed to erosive nodules on the extremities for 2 years. Several biopsies revealed hyperkeratosis, liquefactive degeneration of the basal layer, and a bandlike predominantly lymphocytic infiltrate. Based on the clinical and histologic findings, the patient was diagnosed with keratosis lichenoides chronica, a rare chronic dermatosis that is particularly uncommon in childhood. Read More

    Expression of Granulysin and FOXP3 in Cutaneous T Cell Lymphoma and Sézary Syndrome.
    Asian Pac J Cancer Prev 2015 ;16(13):5359-64
    Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt E-mail :
    Background: Multiple complex pathways are operable in the evolution of cutaneous T cell lymphomas (CTCLs). These pathways involve interaction between neoplastic T cells and cells of the immune system (especially dendritic cells and the non-malignant T cells). Granulysin is a proinflammatory antimicrobial peptide which has an immune alarmin function, activating dendritic cells, as well as an active role in tumor immunology and prognosis. Read More

    Poikilodermatous mycosis fungoides: clinical and histopathological analysis of a case and literature review.
    Acta Dermatovenerol Alp Pannonica Adriat 2015 ;24(2):37-41
    Department of Dermatology, Belarusian State Medical University, Minsk, Belarus.
    Poikilodermatous mycosis fungoides is a rare distinct clinical variant of cutaneous T-cell lymphoma (CTCL), formerly referred to as poikiloderma vasculare atrophicans or parapsoriasis variegata. Mycosis fungoides (MF) is a malignant neoplasm of T-lymphocyte origin, most commonly memory CD4+ T-cells.We report here a patient with generalized poikilodermatous skin lesions whose diagnosis of mycosis fungoides was made only a few years after the onset of his disease due to its bizarre clinical behavior and a natural reluctance to diagnose this disease in children and adolescents. Read More

    ALK-positive primary cutaneous T-cell-lymphoma (CTCL) with unusual clinical presentation and aggressive course.
    J Cutan Pathol 2015 Nov 25;42(11):870-7. Epub 2015 Jun 25.
    Department of Dermatology, University of Kiel, Kiel, Germany.
    Anaplastic lymphoma kinase (ALK) expression is uncommon in primary cutaneous T-cell-lymphomas (CTCL). We report the case of a patient who was initially diagnosed with small plaque parapsoriasis, and eventually developed an unusual manifestation of CTCL 6 years later. The disease was characterized by aggressively ulcerating plaques and tumors of the entire skin. Read More

    A Case of Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma Misdiagnosed as Febrile Ulceronecrotic Mucha-Habermann Disease.
    Acta Derm Venereol 2016 Jan;96(1):136-7
    Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangwangmiao Street 12, Nanjing, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangwangmiao Street 12, Nanjing, Jiangsu 210042, China.

    Benefits of controlled ultraviolet radiation in the treatment of dermatological diseases.
    Coll Antropol 2014 Dec;38(4):1249-53
    Phototherapy is a second-line treatment modality for the most common dermatoses that is safe and effective. Most phototherapy regimens denote the use of ultraviolet (UV) radiation of different wavelengths in the management of several dermatoses. Currently, irradiations with broadband UVB (290-320 nm), narrowband UVB (311-313 nm), 308 nm excimer laser, UVA 1 (340-400 nm), UVA with psoralen (PUVA), and extracorporeal photochemotherapy (photopheresis) are being used. Read More

    Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options.
    Pediatr Dermatol 2015 Sep-Oct;32(5):579-92. Epub 2015 Mar 26.
    Department of Dermatology, Columbia University, New York, New York.
    Pityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English-language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children. Read More

    Poikiloderma vasculare atrophicans: a distinct clinical entity?
    Indian J Dermatol 2015 Mar-Apr;60(2):216
    Department of Dermatology, Venereology and Leprosy, Dr. RP Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
    This paper describes a typical case of poikiloderma vasculare atrophicans (PVA) in a 48-year-old female. Histologically, the features were suggestive of PVA with the absence of Pautrier's microabscess or atypical lymphoid cells. The biopsy specimen was positive for cluster of differentiation (CD) 8 on immunohistochemical staining. Read More

    Differentiation of pityriasis lichenoides chronica from guttate psoriasis by dermoscopy.
    Clin Exp Dermatol 2015 Oct 16;40(7):804-6. Epub 2015 Feb 16.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Italy.
    Clinical differentiation between pityriasis lichenoides chronica (PLC) and guttate psoriasis (GP) may sometimes be a difficult task, which often requires histological analysis to reach a definitive diagnosis. In this study, PLC and GP lesions were examined using dermoscopy, and the significance of specific dermoscopic findings was investigated in order to facilitate their differentiation and decrease the number of cases requiring biopsy. We found that the incidence of orange-yellowish structureless areas, focal dotted vessels and nondotted vessels was statistically significant in PLC, while the incidence of diffuse dotted vessels was statistically significant in GP. Read More

    Febrile ulceronecrotic Mucha-Habermann disease following suspected hemorrhagic chickenpox infection in a 20-month-old boy.
    Infection 2015 Oct 28;43(5):583-8. Epub 2015 Jan 28.
    Department of Pediatrics, University Medicine Greifswald, Ferdinand-Sauerbruchstrasse 1, 17475, Greifswald, Germany.
    We present the youngest pediatric patient so far with febrile ulcerative Mucha-Haberman disease (FUMHD) after an admitting clinical picture of hemorrhagic varicella infection. With a time to diagnosis of 25 days, the 20-month-old boy responded to low dose cyclosporine and prednisolone given for 3 months and is free of disease after 4 years of follow up. We describe a polyclonal CD8+ T cell response with elevated pro-inflammatory cytokines and a fivefold upregulation of the high-affinity Fc receptor type I (CD64) on granulocytes. Read More

    Biopsying parapsoriasis: quo vadis? Are morphological stains enough or are ancillary tests needed?
    Rom J Morphol Embryol 2014 ;55(3 Suppl):1085-92
    Department of Microscopic Morphology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;
    Background: Parapsoriasis represents a group of cutaneous disorders that shows variable clinical aspects somehow resembling to psoriasis, how is reflecting by its name. It was first named by Brocq, in 1902, as an entity with three components: pityriasis lichenoides, small plaque parapsoriasis and large plaque parapsoriasis. Nowadays, under the name of parapsoriasis are included only the last two categories, that are considered disorders characterized by the presence of a mononuclear infiltrate in the dermis, composed of T-cells. Read More

    Childhood hypopigmented mycosis fungoides: a commonly delayed diagnosis.
    BMJ Case Rep 2014 Dec 23;2014. Epub 2014 Dec 23.
    Coimbra University Hospital, Coimbra, Portugal.
    Primary cutaneous lymphomas (PCLs) are exceedingly rare in children and adolescents, with mycosis fungoides (MF) being the most frequent PCL diagnosed in childhood. There are numerous unusual clinical variants of MF, including the hypopigmented type form (HMF). HMF is exceptional overall, but comparatively common among children. Read More

    γδ T-cell-rich variants of pityriasis lichenoides and lymphomatoid papulosis: benign cutaneous disorders to be distinguished from aggressive cutaneous γδ T-cell lymphomas.
    Br J Dermatol 2015 Feb 15;172(2):372-9. Epub 2014 Dec 15.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Suite 1600, Chicago, IL, 60611, U.S.A.
    Background: T cells with a γδ phenotype have been associated with aggressive lymphomas. Yet, inflammatory skin disorders and low-grade lymphoproliferative disorders have rarely been described with a predominant γδ T-cell infiltrate.

    Objectives: To review our experience and determine the clinical relevance of the γδ T-cell phenotype in lymphomatoid papulosis (LyP) and pityriasis lichenoides (PL). Read More

    Adult pityriasis lichenoides-like mycosis fungoides: a clinical variant of mycosis fungoides.
    Int J Dermatol 2014 Nov 25;53(11):1331-8. Epub 2014 Jun 25.
    Department of Dermatology, General Hospital of Valencia, Valencia, Spain.
    Background: Mycosis fungoides (MF) is the most frequent type of cutaneous T cell lymphoma. Its clinicopathological spectrum is wide, and the resulting diversity makes it difficult to establish a differential diagnosis among pityriasis lichenoides (PL), lymphomatoid papulosis (LyP), and atypical MF.

    Objectives: This study describes four patients with longstanding PL-like lesions, in whom clinicopathological correlations contributed towards the establishment of definitive diagnoses of MF. Read More

    Subsequent cancers, mortality, and causes of death in patients with mycosis fungoides and parapsoriasis: a Danish nationwide, population-based cohort study.
    J Am Acad Dermatol 2014 Sep 14;71(3):529-35. Epub 2014 May 14.
    Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
    Background: Data on subsequent cancers, prognostic factors for mortality, and causes of death are limited in mycosis fungoides (MF) and parapsoriasis.

    Objectives: To assess subsequent cancers, mortality, and causes of death in MF and parapsoriasis.

    Methods: Using the Danish nationwide population-based registries, we identified 368 MF patients and 582 parapsoriasis patients and compared them with the general Danish population for subsequent cancers, mortality, and causes of death. Read More

    Extreme dermatology--the intensive care skills of dermatologists in three case presentations of acute skin failure.
    Acta Dermatovenerol Croat 2014 ;22(1):44-7
    Professor Carmen Maria Sălăvăstru, MD, PhD 2nd Clinic of Dermatology, Colentina Clinical Hospital, Buchares,t Romania;
    Dermatological emergencies include a number of clinical conditions usually accompanied by systemic symptoms that can lead to life-threatening complications. From the broad spectrum of life-threatening dermatoses, three cases are presented: a case of febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a case of pemphigus vulgaris mimicking Stevens-Johnson syndrome (SJS), and a case of toxic epidermal necrolysis (TEN). Those cases were considered extreme, and presented to illustrate the positive outcome of timely intensive dermatological care. Read More

    Hypopigmented interface T-cell dyscrasia: a form of cutaneous T-cell dyscrasia distinct from hypopigmented mycosis fungoides.
    J Dermatol 2014 Jul 8;41(7):609-17. Epub 2014 May 8.
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA.
    Hypopigmentation in cutaneous T-cell lymphoproliferative disease should not always be equated with hypopigmented mycosis fungoides (MF). A form of hypopigmented pre-lymphomatous T-cell dyscrasia falling under the designation of the so-called hypopigmented interface variant of T-cell dyscrasia has recently been proposed. The aim of the present study was to establish hypopigmented interface T-cell dyscrasia as its own entity apart from other T-cell dyscrasias and MF using a patient case series. Read More

    Efficacy of low-dose ultraviolet a-1 phototherapy for parapsoriasis/early-stage mycosis fungoides.
    Photochem Photobiol 2014 Jul-Aug;90(4):873-7. Epub 2014 Mar 5.
    Department of Dermatology and Venereology, Uludag University School of Medicine, Bursa, Turkey.
    Mycosis fungoides (MF) and parapsoriasis (PP) are major dermatologic conditions for which phototherapy continues to be a successful and valuable treatment option. UVA-1 phototherapy is effective in the management of cutaneous T-cell mediated diseases. The aim of the study was to evaluate the efficacy and safety of low-dose UVA-1 phototherapy for the management of PP/early-stage MF. Read More

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