31,665 results match your criteria Paraneoplastic Syndromes


Anti-CASPR2 clinical phenotypes correlate with HLA and immunological features.

J Neurol Neurosurg Psychiatry 2020 Jul 10. Epub 2020 Jul 10.

French National Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hôpital Neurologique, Hospices Civils de Lyon, Bron, France

Objective: Antibodies against contactin-associated protein-like 2 (CASPR2-Abs) have been described in acquired neuromyotonia, limbic encephalitis (LE) and Morvan syndrome (MoS). However, it is unknown whether these constitute one sole spectrum of diseases with the same immunopathogenesis or three distinct entities with different mechanisms.

Methods: A cluster analysis of neurological symptoms was performed in a retrospective cohort of 56 CASPR2-Abs patients. Read More

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http://dx.doi.org/10.1136/jnnp-2020-323226DOI Listing

[Detecting skin cancer: paraneoplastic skin diseases].

Authors:
B Gualtieri M Hertl

Internist (Berl) 2020 Jul 8. Epub 2020 Jul 8.

Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg (UKGM), Baldingerstraße, 35043, Marburg, Deutschland.

Skin diseases represent the second most common paraneoplastic manifestations after endocrine disorders. Paraneoplastic dermatoses may arise as the first clinical sign of occult malignancies, or manifest during the course of a previously diagnosed neoplasm. Dermatoses belonging to the group of obligate paraneoplastic syndromes manifest only in the presence of underlying malignancies. Read More

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http://dx.doi.org/10.1007/s00108-020-00831-yDOI Listing

Autoimmune encephalitis: current knowledge on subtypes, disease mechanisms and treatment.

CNS Neurol Disord Drug Targets 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology, Odense University Hospital, Odense. Denmark.

Autoimmune encephalitides (AE) comprises a group of diseases with antibodies against neuronal synaptic and cell surface antigens. Since the discovery of the most common subtype, N-Methyl-D-Aspartate (NMDA) receptor encephalitis, an astonishing number of novel disease-causing antibodies have been described. This includes other glutamatergic and GABAergic receptor antibodies and antibodies against various other surface proteins. Read More

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http://dx.doi.org/10.2174/1871527319666200708133103DOI Listing

Opsoclonus-ataxia syndrome and mature ovarian teratoma in an adolescent.

Gynecol Oncol Rep 2020 Aug 24;33:100601. Epub 2020 Jun 24.

Department of Obstetrics, Gynecology, and Reproductive Sciences Yale University School of Medicine, CT 06520, USA.

•Ovarian teratomas have been implicated in multiple paraneoplastic syndromes.•Opsoclonus-ataxia syndrome is a rare entity that may be secondary to a paraneoplastic, infectious, or idiopathic process.•Opsoclonus-ataxia syndrome may be associated with ovarian teratoma in both children and adults. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327890PMC

Pathophysiology of paraneoplastic and autoimmune encephalitis: genes, infections, and checkpoint inhibitors.

Ther Adv Neurol Disord 2020 24;13:1756286420932797. Epub 2020 Jun 24.

Centre de Référence National pour les Syndromes Neurologiques Paranéoplasiques, Hôpital Neurologique, 59 Boulevard Pinel, Bron Cedex, 69677, France.

Paraneoplastic neurological syndromes (PNSs) are rare complications of systemic cancers that can affect all parts of the central and/or peripheral nervous system. A body of experimental and clinical data has demonstrated that the pathogenesis of PNSs is immune-mediated. Nevertheless, the mechanisms leading to immune tolerance breakdown in these conditions remain to be elucidated. Read More

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http://dx.doi.org/10.1177/1756286420932797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318829PMC

Paraneoplastic Musculoskeletal Syndromes.

Rheum Dis Clin North Am 2020 Aug 7;46(3):577-586. Epub 2020 Jun 7.

Division of Rheumatology and Immunology, Department of Internal Medicine, Columbus, OH, USA. Electronic address:

Paraneoplastic syndromes are rare diseases caused by malignancies through means other than mass effect or metastasis. Paraneoplastic phenomena can be the first sign of cancer and can be fatal. Paraneoplastic rheumatic syndromes can occur with hematologic cancers, lymphoproliferative disease, and solid tumors. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.04.002DOI Listing

[Virus-induced opsoclonus-myoclonus syndrome during pregnancy].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):93-99

Almazov National Medical Research Centre, St. Petersburg, Russia.

Opsoclonus-myoclonus syndrome (OMS) is a very rare condition with various etiologies (paraneoplastic, parainfectious, toxic, idiopathic, etc.) with an autoimmune pathogenetic mechanism of development. The authors describe the case of OMS in a 41-year-old woman at 37 weeks of gestation, who developed opsoclonus, myoclonus, severe trunk ataxia, tremor and bilateral pyramidal symptoms, inability to sit, stand and walk without support. Read More

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http://dx.doi.org/10.17116/jnevro202012005193DOI Listing

[Research progress on electroencephalogram characteristics of anti-N-methyl-D-aspartate receptor encephalitis].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 May;49(1):118-123

The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a kind of autoimmune disease aiming at NR1 subunit of NMDA receptor. In the early stage, functional damage is the main cause. Electroencephalogram (EEG) can reflect the abnormal brain function by recording the changes of EEG signals. Read More

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[Cryptococcal Encephalitis Complicating Anti-N-methyl-D-aspartate Receptor Encephalitis in an Immunosuppressed Patient].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):417-420

Department of Geriatric Neurology,Xiangya Hospital,Central South University,Changsha 410008,China.

Cryptococcal encephalitis is a fatal central nervous system infectious disease,whereas anti-N-methyl-D-aspartate(NMDA)receptor encephalitis(NMDARE)is an autoimmune syndrome associated with psychological symptoms,behavioural abnormalities,seizures,and dyskinesias.Despite their distinct pathologies and pathogenic mechanisms,both of them can lead to cognitive dysfunction and abnormal behaviors,although anti-NMDARE can also have mood and mental disorders as its core manifestations.A patient with nephrotic syndrome accompanied by both cryptococcal encephalitis and anti-NMDARE was treated in our center,which for the first confirmed that these two conditions could coexist in one patient. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11472DOI Listing

[Research Advances in Follicular Regulatory T Cells in Ocular Myasthenia Gravis].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):383-387

Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China.

Myasthenia gravis(MG)is a B cell-mediated,T cell-dependent,complements-involved autoimmune disease.Ocular myasthenia gravis(OMG)is a typical MG,with its symptoms limited to the extraocular muscles.The occurrence and development of a variety of autoimmune diseases including OMG are closely associated with the imbalanced expression of follicular regulatory T cells(Tfr cells). Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11252DOI Listing

Oncorheumatology: relationship between malignancies and musculoskeletal diseases

Orv Hetil 2020 07;161(28):1151-1165

Klinikai Központ, Onkológiai Klinika,Debreceni Egyetem, Általános Orvostudományi Kar, Debrecen.

Oncorheumatology is the meeting point of tumour formation and rheumatic diseases. Multiple interactions exist between these two medical specialties. One major field is the topic of malignancies associated with rheumatic diseases, while the other topic covers the development of musculoskeletal disease in cancer patients. Read More

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http://dx.doi.org/10.1556/650.2020.31800DOI Listing

Eosinophilic dermatosis of hematologic malignancy: a case report.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Department of Dermatovenereology, Hospital de Braga, Braga.

Eosinophilic dermatosis of hematologic malignancy (EDHM) is a dermatosis characterized by tissue eosinophilia that has been previously reported as insect bite-like reaction. It is a rare condition with a wide variety of clinical presentations ranging from papules, nodules, or blisters that simulate arthropod bites, to the formation of plaques of differing sizes. We report a case of eosinophilic dermatosis of hematologic malignancy in a patient with a hematoproliferative disorder. Read More

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Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2.

Pract Neurol 2020 Jun 28. Epub 2020 Jun 28.

Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

Autoantibodies to leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein like-2 (CASPR2) are associated with clinically distinctive syndromes that are highly immunotherapy responsive, such as limbic encephalitis, faciobrachial dystonic seizures, Morvan's syndrome and neuromyotonia. These autoantibodies target surface-exposed domains of LGI1 or CASPR2, and appear to be directly pathogenic. In contrast, voltage-gated potassium channel (VGKC) antibodies that lack LGI1 or CASPR2 reactivities ('double-negative') are common in healthy controls and have no consistent associations with distinct syndromes. Read More

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http://dx.doi.org/10.1136/practneurol-2019-002494DOI Listing

Transient Neurological Symptoms Preceding Cerebellar Ataxia with Glutamic Acid Decarboxylase Antibodies.

Cerebellum 2020 Jun 26. Epub 2020 Jun 26.

French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France.

A prompt diagnosis and treatment of patients with autoimmune cerebellar ataxia (CA) with antibodies against glutamic acid decarboxylase (GAD-Abs) may lead to a better prognosis. Herein, we report prodromal transient neurological symptoms that should raise clinical suspicion of CA with GAD-Abs. We initially identified a 70-year-old man who presented a first acute episode of vertigo, diplopia, and ataxia lasting 2 weeks. Read More

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http://dx.doi.org/10.1007/s12311-020-01159-xDOI Listing

Cerebellar ataxia as the initial symptom with lesions involving the cerebellum in patient with anti-NMDAR encephalitis: A rare case report and literature review.

J Neuroimmunol 2020 Jun 17;346:577293. Epub 2020 Jun 17.

Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China. Electronic address:

Cerebellar ataxia is an atypical presentation of anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. In patients with anti-NMDAR encephalitis, cerebellar ataxia often develops simultaneously or sequentially with clinical features of demyelinating disorders, paraneoplastic neurologic syndromes, despite unremarkable brain magnetic resonance imagerying (MRI) findings. Herein, we report a patient with anti-NMDAR encephalitis who developed dizziness and gait ataxia as the initial symptoms, simultaneously showing MRI hyperintensities involving the cerebellum, even before manifesting behavioral and cognitive symptoms. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577293DOI Listing

Renal cell carcinoma associated with idiopathic thrombocytopenic purpura.

Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420931619

Department of Urology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

We presented the clinical data of one patient with renal cell carcinoma associated with idiopathic thrombocytopenic purpura in this case report. We reported a 56-year-old man who presented with petechiae and ecchymoses. Laboratory studies showed the platelet count of 2 × 10/L and an abdominal computed tomography (CT) scan revealed tumors in the right renal. Read More

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http://dx.doi.org/10.1177/2058738420931619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309373PMC

Paraneoplastic Raynaud phenomenon associated with metastatic ovarian cancer: A case report and review of the literature.

Gynecol Oncol Rep 2020 Aug 26;33:100575. Epub 2020 Apr 26.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.

•Paraneoplastic syndromes are rarely associated with ovarian malignancies.•Paraneoplastic syndromes may be the presenting symptom of an underlying malignancy.•Rheumatologic disorders with unusual presentations may be malignancy related. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284054PMC

Anti-Ri-associated paraneoplastic ophthalmoplegia-ataxia syndrome in a woman with breast cancer: a case report and review of the literature.

J Med Case Rep 2020 Jun 12;14(1):67. Epub 2020 Jun 12.

Department of Medical and Surgical Sciences, U.O. of General Surgery, University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.

Background: Breast cancer is the most common cancer in women. However, in the management of breast cancer, paraneoplastic neurological syndromes represent a diagnostic and therapeutic challenge. The diagnosis of paraneoplastic neurological syndromes is difficult due to the heterogeneity of symptoms, the timing of presentation, and the absence of antibodies, and it generally occurs before the diagnosis of breast cancer in 80% of patients who develop paraneoplastic neurological syndromes. Read More

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http://dx.doi.org/10.1186/s13256-020-02410-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291432PMC

COVID-19-associated acute necrotizing myelitis.

Neurol Neuroimmunol Neuroinflamm 2020 09 10;7(5). Epub 2020 Jun 10.

From the Neurology Department (J.S.) and Radiology Department (Y.R.-Á.), Hospital Universitari Mútua Terrassa, Spain.

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http://dx.doi.org/10.1212/NXI.0000000000000803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309521PMC
September 2020

Paraneoplastic Pemphigus Mimicking Toxic Epidermal Necrolysis Associated with Follicular Lymphoma: Possible Pathological Role of CD8 T Cells.

Acta Derm Venereol 2020 Jul 2;100(14):adv00204. Epub 2020 Jul 2.

Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520-2192, Japan. E-mail:

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http://dx.doi.org/10.2340/00015555-3557DOI Listing

Chance to rein in a cancer--Spontaneous regression of lung carcinoma (1988-2018): a 30-year perspective.

Int J Clin Exp Pathol 2020 1;13(5):1190-1196. Epub 2020 May 1.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China.

Background: Spontaneous regression of tumor is an extremely rare phenomenon in the oncology field and even rarer for lung cancer. However, the underlying mechanism is poorly understood. Summarizing the available clinical information and the supposed mechanism shed new light on lung cancer therapy strategies in the new era of immunotherapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270659PMC

COVID-19 in Refractory Myasthenia Gravis- A Case Report of Successful Outcome.

J Neuromuscul Dis 2020 ;7(3):361-364

Department of Neurology, University of Missouri, Columbia, Missouri.

This is a brief report of a patient who has refractory Myasthenia Gravis, on multiple long-term immunosuppressive therapies and contracted COVID-19 during this 2020 pandemic. She was quarantined for total of 14 days and recovered successfully without any complications (no myasthenia exacerbation or crisis, no COVID-19 related complications), with no changes to her immunosuppressive therapy. Treatment of MG patients with COVID-19 needs to be tailored to individual patient. Read More

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http://dx.doi.org/10.3233/JND-200520DOI Listing

Doege-Potter Syndrome and Pierre-Marie-Bamberger Syndrome in a Patient With Pleural Solitary Fibrous Tumor: A Rare Case With Literature Review.

Cureus 2020 May 1;12(5):e7919. Epub 2020 May 1.

Internal Medicine, Creighton University Arizona Health Education Alliance/Valleywise Health Medical Center, Phoenix, USA.

Solitary fibrous tumors (SFT) represent a unique subset of mostly benign heterogeneous tumors with mesenchymal cell origins. These tumors have been reported in the past as being mostly indolent, with a slowly evolving clinical course and low potential for malignancy. Although found systemically, the incidence of SFT arising intrathoracically, from the pleura of the lung, is relatively poorly documented in the medical literature. Read More

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http://dx.doi.org/10.7759/cureus.7919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263730PMC

The Game Is Afoot.

N Engl J Med 2020 06;382(23):2249-2255

From the Departments of Medicine (N.Y., A.L.M., J.L.), Pathology (J.L.H.), and Orthopedic Surgery (C.P.C.), Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1913599DOI Listing

Diffuse large B-Cell lymphoma associated with paraneoplastic Guillain-Barré syndrome: A diagnostic and therapeutic challenge.

Hematol Oncol Stem Cell Ther 2020 May 20. Epub 2020 May 20.

Roswell Park Comprehensive Cancer Centre, Buffalo, NY, USA. Electronic address:

Paraneoplastic neurological syndromes are a rare manifestation of non-Hodgkin lymphoma and can make treatment of these patients more challenging. We report the case of a 67-year-old man with high grade diffuse large B-cell lymphoma who presented with severe paraneoplastic Guillain-Barré syndrome. He was treated with intravenous immunoglobulin therapy and definitive chemoimmunotherapy, and achieved a full neurological recovery. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.05.008DOI Listing

Neurological Syndromes Associated with Anti-GAD Antibodies.

Int J Mol Sci 2020 May 24;21(10). Epub 2020 May 24.

AP-HP, Groupe Hospitalier Pitié-Salpêtrière, service de Neurologie 2-Mazarin, 75013 Paris, France.

Glutamic acid decarboxylase (GAD) is an intracellular enzyme whose physiologic function is the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter within the central nervous system. GAD antibodies (Ab) have been associated with multiple neurological syndromes, including stiff-person syndrome, cerebellar ataxia, and limbic encephalitis, which are all considered to result from reduced GABAergic transmission. The pathogenic role of GAD Ab is still debated, and some evidence suggests that GAD autoimmunity might primarily be cell-mediated. Read More

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http://dx.doi.org/10.3390/ijms21103701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279468PMC

Anti-NMDA receptor encephalitis in a psychiatric Covid-19 patient: A case report.

Brain Behav Immun 2020 07 23;87:179-181. Epub 2020 May 23.

Department of Mental Health and Addiction Services, Niguarda Hospital, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2020.05.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255176PMC

Anti-Hu-associated paraneoplastic syndromes triggered by immune-checkpoint inhibitor treatment.

J Neurol 2020 Jul 25;267(7):2154-2156. Epub 2020 May 25.

French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, Lyon, France.

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http://dx.doi.org/10.1007/s00415-020-09940-yDOI Listing

Rhombencephalitis associated with isolated Zic4-antibodies in Paraneoplastic cerebellar degeneration: a case report.

BMC Neurol 2020 May 25;20(1):208. Epub 2020 May 25.

Department of Neurology, University Hospital of Gießen and Marburg, Marburg, Germany.

Background: Cerebellar degeneration as a consequence of a malignancy is a rare condition most commonly related to the presence of anti-Yo, anti-Hu, and anti-Tr/DNER antibodies. In recent years, several reports have indicated Zinc-finger protein 4 (Zic4) antibodies being associated with paraneoplastic cerebellar degeneration (PCD) in patients with small cell lung carcinoma. However, the prevalence and the significance of Zic4-antibodies may be underestimated due to their co-occurrence with more frequent antibodies such as anti-Hu. Read More

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http://dx.doi.org/10.1186/s12883-020-01788-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249364PMC

Etomidate infusion at low doses is an effective and safe treatment for severe Cushing's syndrome outside intensive care.

Eur J Endocrinol 2020 Aug;183(2):161-167

Endocrinology Department, Cliniques Universitaires Saint Luc, Brussels, Belgium.

Introduction: Intravenous etomidate infusion is effective to rapidly lower cortisol levels in severe Cushing's syndrome (CS) in the intensive care unit (ICU). Recently, etomidate treatment has also been proposed at lower doses in non-ICU wards, but it is not yet clear how this approach compares to ICU treatment.

Methods: We compared data from patients with severe CS treated with high starting doses of etomidate (median: 0. Read More

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http://dx.doi.org/10.1530/EJE-20-0380DOI Listing

Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis.

Gene 2020 Aug 19;752:144774. Epub 2020 May 19.

Department of Translational Research and of New Surgical and Medical Technologies, Lab. of Medical Genetics, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy; Department of Laboratory Medicine, Pisa University Hospital, Pisa, Italy.

Background: Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation levels in thymic epithelial tumors, and particularly in thymomas from patients with Myasthenia Gravis (TAMG).

Material And Methods: In the present study we collected DNA samples from circulating lymphocytes and surgically resected tumor tissues of 65 TAMG patients, and from the adjacent healthy thymic tissue available from 43 of them. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144774DOI Listing

Myasthenic crisis in COVID-19.

J Neurol Sci 2020 07 6;414:116888. Epub 2020 May 6.

Department of Neurology, Wayne State University and Detroit Medical Center, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2020.116888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200364PMC

Long lasting trigeminal neuropathy, limbic encephalitis and abdominal ganglionitis without primary cancer: An atypical case of Hu-antibody syndrome.

Clin Neurol Neurosurg 2020 Jul 18;194:105849. Epub 2020 Apr 18.

Neurology Department, Gent University Hospital, Gent, Belgium; Neurology Department, St Lucas General Hospital Gent, Belgium.

Objectives: Anti-Hu antibodies (Hu-Abs) are the most frequent onconeural antibodies associated with paraneoplastic neurologic syndromes (PNS). PNS include a variety of neurological syndromes, affecting less than 1/10,000 patients with cancer. In the majority of cases, PNS will manifest before the malignancy is diagnosed. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105849DOI Listing

Value of Onconeural Antibodies in Checkpoint Inhibitor-Related Toxicities.

Ann Neurol 2020 Jul 19;88(1):199-200. Epub 2020 May 19.

National Reference Center for Paraneoplastic Neurological Syndromes, Lyon Civil Hospices, Neurological Hospital, Lyon, France.

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http://dx.doi.org/10.1002/ana.25764DOI Listing

Recurrent Thymoma-Associated Paraneoplastic Encephalitis Resulting From Multiple Antibodies: A Case Report.

Neurohospitalist 2020 Apr 13;10(2):139-142. Epub 2019 Oct 13.

Department of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA.

Few reports describe the clinical course and acute-care management of patients with recurrent multi-antibody paraneoplastic encephalitis. We describe a rare case of a patient having thymoma with multiple paraneoplastic syndromes who was found to have antibodies to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) followed by -methyl-d-aspartate (NMDA) receptor in the setting of residual thymic tissue. He initially presented to the hospital with severe, rapidly progressive encephalitis with simultaneous antibodies to AMPA and voltage-gated potassium channel complex receptor. Read More

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http://dx.doi.org/10.1177/1941874419880423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191667PMC

Retrospective Analysis of Mortality Cases in Advanced and Metastatic Solid Tumors With Concurrent Prerenal Azotemia.

In Vivo 2020 May-Jun;34(3):1515-1519

Division of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan, R.O.C.

Background/aim: A retrospective study of cases with metastatic or advanced solid tumors complicated with AKI (acute kidney injury) with prerenal azotemia.

Patients And Methods: Criteria included: (1) advanced or metastatic solid tumors that led to mortality; (2) prerenal azotemia identified upon renal function evaluation and (3) BUN to Cr ratio (BCR)≥15. We also compared the outcomes of patients with BCR>20 with those of patients with BCR=15-20. Read More

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http://dx.doi.org/10.21873/invivo.11939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279785PMC
February 2020

Neurological Implications of COVID-19 Infections.

Neurocrit Care 2020 06;32(3):667-671

Division of Anaesthesia, University of Cambridge, Cambridge, UK.

The magnitude of the COVID-19 pandemic will result in substantial neurological disease, whether through direct infection (rare), para-infectious complications (less rare), or critical illness more generally (common). Here, we raise the importance of stringent diagnosis and data collection regarding neurological complications of COVID-19; we urge caution in the over-diagnosis of neurological disease where it does not exist, but equally strongly encourage the concerted surveillance for such conditions. Additional to the direct neurological complications of COVID-19 infection, neurological patients are at risk of harm from both structural limitations (such as number of intensive care beds), and a hesitancy to treat with certain necessary medications given risk of nosocomial COVID-19 infection. Read More

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http://dx.doi.org/10.1007/s12028-020-00978-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188454PMC

Cholestatic Hepatitis as a Possible Paraneoplastic Syndrome of Endometrial Carcinoma.

ACG Case Rep J 2020 Mar 17;7(3):e00350. Epub 2020 Mar 17.

Division of Gastroenterology, Department of Internal Medicine, Saint Louis University College of Medicine, Saint Louis, MO.

Cholestatic hepatitis has not been reported as a paraneoplastic syndrome of endometrial adenocarcinoma to our knowledge. We present a patient who, shortly after endometrial adenocarcinoma diagnosis, presented with elevated liver chemistries in the setting of an acute, paraneoplastic sensorimotor polyneuropathy. Infectious, autoimmune, pharmacologic, malignant, metabolic, and structural causes of cholestatic hepatitis were screened for and ruled out. Read More

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http://dx.doi.org/10.14309/crj.0000000000000350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162118PMC

Acupuncture for ocular myasthenia gravis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Apr;99(17):e19901

The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Background: The aim of this systematic review with meta-analysis is to determine the efficacy and security of acupuncture in treatment of ocular myasthenia gravis and find out whether or not the quick short-term efficacy of acupuncture exists.

Methods: The following electronic databases will be searched by 2 independent reviewers: PubMed, Cochrane Library, EMBASE, Springer, China National Knowledge Infrastructure, Wanfang, and Chinese Biomedical Literature Database. All randomized controlled trials on acupuncture for ocular myasthenia gravis published in electronic databases from inception to March 1, 2020, with language restricted in Chinese and English will be included in the study. Read More

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http://dx.doi.org/10.1097/MD.0000000000019901DOI Listing
April 2020
5.723 Impact Factor

Risk factors for pneumonia in patients with anti-NMDA receptor encephalitis: A single-center retrospective study.

Medicine (Baltimore) 2020 Apr;99(17):e19802

Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan.

To identify the risk factors of pneumonia in patients with Anti-N-methyl-D-aspartate (Anti-NMDA) receptor encephalitis.This is a retrospective study.Department of Neurology in West China Hospital of Sichuan University. Read More

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http://dx.doi.org/10.1097/MD.0000000000019802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220633PMC

Ulcerative Colitis in Hematological Malignancies: Paraneoplastic Manifestation or Coincidental Bystander?

Case Rep Gastrointest Med 2020 23;2020:6135425. Epub 2020 Mar 23.

Department of Surgery, University Hospital of Larissa, Mezourlo 41110, Larissa, Greece.

Evidence of coexistence of diverse hematological malignancies-lymphoma, leukemia, multiple myeloma, and myelodysplastic syndromes-and either ulcerative colitis or Crohn's disease can be found in the literature. However, a more "systemic" effort to reach further and examine the potential of either one as paraneoplastic manifestation has not been performed. Based on these, three cases of ulcerative colitis manifesting before, simultaneously, and after the onset of different hematological malignancies are presented and critically evaluated. Read More

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http://dx.doi.org/10.1155/2020/6135425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128061PMC

Current Techniques to Accurately Measure Anti-retinal Autoantibodies.

Authors:
Grazyna Adamus

Expert Rev Ophthalmol 2020 12;15(2):111-118. Epub 2020 Mar 12.

Ocular Immunology Laboratory, Casey Eye Institute, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Introduction: Autoimmune retinopathy (AR) is a sight-threating retinal disorder that is mediated by autoantibodies (AAbs) against retinal proteins. The visual paraneoplastic syndromes, including cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR) are mediated by anti-retinal AAbs. A number of immunochemical techniques have been used to detect serum anti-retinal autoantibodies in patients to help with autoimmune diagnosis. Read More

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http://dx.doi.org/10.1080/17469899.2020.1739522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172387PMC

[Review of correlation between human parvovirus B19 and autoimmune disease etiology].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 Jan;36(1):75-80

Department of Pathology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China. *Corresponding author, E-mail:

Human parvovirus B19 (PVB19) is a small single strand DNA virus distributed throughout the world, with its encoded products being three known proteins. There is conclusive evidence that PVB19 infection is a crucial inducement of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Hashimoto's thyroiditis (HT), myasthenia gravis (MG) and other autoimmune diseases (AIDs). Recent studies have confirmed that anti-B19-VP1u-IgG antibody is able to increase the activity of cytokines such as interleukin 1 (IL-1), tumor necrosis factor α (TNF-α), matrix metalloproteinase-9 (MMP9); PVB19 protein NS 1 and VP1u are capable of inducing the expression of IL-6; PVB19 can induce the production of Th17 cell-related cytokines, resulting in the decrease of IFN-gamma levels and the increase of IL-4 levels in plasma. Read More

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January 2020

Central nervous system complications associated with immune checkpoint inhibitors.

J Neurol Neurosurg Psychiatry 2020 07 20;91(7):772-778. Epub 2020 Apr 20.

Centre National de Référence pour les Syndromes Neurologiques Paranéoplasiques, Hospices Civils de Lyon, Lyon, France

Objective: To describe the spectrum and outcome of central nervous system complications associated with immune checkpoint inhibitors (CNS-ICI).

Methods: Patients with CNS-ICI were identified and their characteristics compared with ICI-related peripheral neuropathy (PN-ICI).

Results: We identified 19 patients with CNS-ICI. Read More

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http://dx.doi.org/10.1136/jnnp-2020-323055DOI Listing

Acupuncture can serve at most only as supplementary therapy for myasthenia gravis.

Authors:
Josef Finsterer

Ann Palliat Med 2020 05 13;9(3):1278-1279. Epub 2020 Apr 13.

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria.

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http://dx.doi.org/10.21037/apm.2020.04.07DOI Listing

Cutaneous manifestations of internal malignancy.

J Dtsch Dermatol Ges 2020 May 20;18(5):456-469. Epub 2020 Apr 20.

Department of Dermatology, University Medical Center, Magdeburg, Germany.

Skin lesions associated with internal malignancy may present as cutaneous metastases or as typical lesions occurring in the context of certain cancer-associated genetic syndromes. Paraneoplastic syndromes, on the other hand, are only indirectly associated with an underlying malignancy and are not malignant per se. Historically, a distinction has been made between "obligate" and "facultative" paraneoplastic disorders, depending on the likelihood with which they are potentially associated with malignancy. Read More

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http://dx.doi.org/10.1111/ddg.14093DOI Listing

Ptosis that resolves with application of an ice pack.

BMJ 2020 Apr 16;369:m1147. Epub 2020 Apr 16.

Milton Keynes University Hospital, Milton Keynes, UK.

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http://dx.doi.org/10.1136/bmj.m1147DOI Listing

Immune Thrombocytopenia Secondary to Hodgkin's Lymphoma in Children

Isr Med Assoc J 2020 04;22(4):224-226

Department of Pediatrics B, Emek Medical Center, Afula, Israel.

Background: Immune thrombocytopenia (ITP) is an autoimmune disorder of variable origin that results in bleeding and decreased platelet count. Autoimmune abnormalities have been described in patients with malignancies including non-Hodgkin's lymphoma but are rarely described in patients with Hodgkin's lymphoma.

Objectives: To describe an unusual presentation of Hodgkin's lymphoma in an unusual age and alarm pediatricians of the challenging diagnosis. Read More

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Concomitant Guillain-Barré Syndrome and Acute Transverse Myelitis in an Older Adult-A Case Report.

Acta Neurol Taiwan 2020 Mar;29(1):12-17

Department of Neurology, Chang Gung Memorial Hospital, Keelung branch, Taiwan.

Purpose: Guillain-Barré syndrome concomitant with spinal cord involvement, which is defined as Guillain-Barré syndrome and acute transverse myelitis overlap syndrome, is rarely seen in the elders. Here we present a 68-year-old female patient who developed Guillain-Barré syndrome, as well as acute transverse myelitis at the same episode.

Case Report: This patient developed acute weakness of lower limbs, which then rapidly became tetraplegia and hyporeflexia within 5 days. Read More

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