5,653 results match your criteria Paraneoplastic Encephalomyelitis


The neurological syndromes associated with glutamic acid decarboxylase antibodies.

J Autoimmun 2019 Apr 15. Epub 2019 Apr 15.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA; University of Guanajuato, Mexico. Electronic address:

A number of neurological syndromes have been described in patients with positive serum antibodies (Abs) against the enzyme glutamic acid decarboxylase (GAD), the rate limiting step in the synthesis of GABA (γ-aminobutyric acid). These disorders include: classical stiff-person syndrome and variants, cerebellar ataxia, limbic and extra-limbic encephalitis, nystagmus/oculomotor dysfunction, drug-resistant epilepsy, paraneoplastic stiff-person syndrome and progressive encephalopathy with rigidity and myoclonus (PERM), the latter two are mainly related to amphiphysin and the glycine receptor Abs respectively; but patients may also have positive GAD-Abs. Although observations are consistent with an autoimmune response in these patients and there is evidence of GABAergic dysfunction in some cases; the pathogenic role of GAD-Abs in the nervous system has not been clarified and it is a matter of debate. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.007DOI Listing
April 2019
2 Reads

Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series.

Mult Scler Relat Disord 2019 Apr 1;31:97-100. Epub 2019 Apr 1.

Center for pathophysiology Toulouse Purpan, INSERM U1043, CNRS 5282, Université Toulouse III, 31024 Toulouse, France; CRC-SEP, Pôle Neurosciences, CHU de Toulouse, 31059 Toulouse, France.

Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory disease of the central nervous system, characterized by the presence of auto-antibodies directed against aquaporin-4 (AQP4) expressed on astrocyte end-feet. Despite NMOSD does not primarily belong to the spectrum of paraneoplastic neurological syndromes, rare cases of association with neoplasia have been outlined. Here, we report the association of NMOSD with ovarian teratoma in 3 cases. Read More

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http://dx.doi.org/10.1016/j.msard.2019.03.031DOI Listing
April 2019
2 Reads

A Longitudinally Extensive Spinal Cord Lesion Restricted to Gray Matter in an Adolescent Male.

Front Neurol 2019 20;10:270. Epub 2019 Mar 20.

Department of Pediatrics, New York University School of Medicine, New York, NY, United States.

Longitudinally extensive spinal cord lesions (LECL) restricted to gray matter are poorly understood as are their neurodevelopmental repercussions in children. We herein report the critical case of a 13-year-old male presenting with progressive quadriparesis found to have cervical LECL restricted to the anterior horns. Challenged with a rare diagnostic dilemma, the clinical team systematically worked through potential vascular, genetic, infectious, rheumatologic, and paraneoplastic diagnoses before assigning a working diagnosis of acute inflammatory myelopathy. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00270
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http://dx.doi.org/10.3389/fneur.2019.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435483PMC
March 2019
4 Reads

[Analysis of Small Cell Lung Cancer with Paraneoplastic Limbic Encephalitis].

Authors:
Mingyi Di Li Zhang

Zhongguo Fei Ai Za Zhi 2019 Mar;22(3):132-136

Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing 100730, China.

Background: The aim of this study was to investigate the clinical features of paraneoplastic limbic encephalitis (PLE) with small cell lung cancer (SCLC) and improve clinical diagnosis and treatment.

Methods: The clinical data of 15 patients with SCLC combined with PLE from January 1980 to May 2017 were collected from Beijing Union Hospital. Their symptoms and laboratory data were analyzed and the prognosis of the patients was followed. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.03.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441114PMC
March 2019
1 Read

Variant Guillain-Barré syndrome in a patient with Hodgkin lymphoma: AMSAN.

Turk Pediatri Ars 2018 Dec 1;53(4):263-266. Epub 2018 Dec 1.

Pediatric Hematology and Oncology Clinic, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.

Lymphomas are solid tumors characterized by the malignant proliferation of lymphoid cells. Neurologic signs encountered in patients with Hodgkin's lymphoma can be due to the direct spread of tumor to the nervous system, secondary to chemotherapy or radiation, secondary to tumor mass compression, infectious causes and paraneoplastic syndromes. Paraneoplastic neurologic syndromes are rarely encountered in patients with Hodgkin's lymphoma and non-Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.4763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408190PMC
December 2018
1 Read

Paraneoplastic neurological syndromes in the era of immune-checkpoint inhibitors.

Nat Rev Clin Oncol 2019 Mar 12. Epub 2019 Mar 12.

Neuroimmunology Programme, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.

Paraneoplastic neurological syndromes (PNSs) comprise a group of disorders that can affect any part of the nervous system in patients with cancer and frequently result from autoimmune responses triggered by the ectopic expression of neuronal proteins in cancer cells. These disorders are rare, although the introduction of immune-checkpoint inhibitors (ICIs) into cancer treatment algorithms has renewed interest in PNSs. ICIs are associated with a considerably increased incidence of immunological toxicities compared with traditional anticancer therapies, including neurological immune-related adverse effects (nirAEs) that can manifest as PNSs. Read More

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http://dx.doi.org/10.1038/s41571-019-0194-4DOI Listing
March 2019
2 Reads

Pediatric anti-NMDA receptor encephalitis with catatonia: treatment with electroconvulsive therapy.

Pediatr Rheumatol Online J 2019 Feb 18;17(1). Epub 2019 Feb 18.

Section of Pediatric Rheumatology, Department of Pediatrics, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC 5044, Chicago, 60637, IL, USA.

Background: Anti-NMDA receptor encephalitis, an autoimmune disease associated with antibodies against N-methyl-D-aspartate (NMDA) receptors, is being diagnosed more frequently, especially in children and young adults. Acute neurological and psychiatric manifestations are the common presenting symptoms. Diagnosing anti-NMDA receptor encephalitis is often challenging given the wide range of clinical presentation, and may be further complicated by its overlap of symptoms, brain MRI changes, and CSF findings with other entities affecting the brain. Read More

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http://dx.doi.org/10.1186/s12969-019-0310-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378721PMC
February 2019
3 Reads

[Guideline for fecal bacteriotherapy to treat recurrent Clostridium difficile colitis].

Klin Mikrobiol Infekc Lek 2018 Jun;24(2):57-64

Department of Inectious Diseases, 3rd Medical faculty, Charles University, Prague, Hospital na Bulovce, Czech Republic, e-mail:

We present a case of a 17-year-old female with anti-NMDAR encephalitis probably associated with vaccination against yellow fever. Her symptoms occurred 27 days after vaccination against yellow fever. Anti-NMDAR encephalitis manifested as acute psychosis, memory loss and catatonia following fever with complex partial epileptic seizures. Read More

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June 2018
4 Reads

Antibody-LGI 1 autoimmune encephalitis manifesting as rapidly progressive dementia and hyponatremia: a case report and literature review.

BMC Neurol 2019 Feb 7;19(1):19. Epub 2019 Feb 7.

Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Background: Anti leucine-rich glioma inactivated 1 (LGI1) encephalitis is a rare autoimmune encephalitis (AE), characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, psychiatric disturbances and hyponatremia. Antibody-LGI 1 autoimmune encephalitis (anti-LGI1 AE) has increasingly been recognized as a primary autoimmune disorder with favorable prognosis and response to treatment.

Case Presentation: Herein, we reported a male patient presenting as rapidly progressive dementia and hyponatremia. Read More

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http://dx.doi.org/10.1186/s12883-019-1251-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366039PMC
February 2019
3 Reads
2.040 Impact Factor

Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection.

Methods Mol Biol 2019 ;1941:225-255

Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to an underlying neoplasm. Some of these paraneoplastic encephalitides express serum antibodies, but these were not thought to be pathogenic but instead have a T-cell-mediated pathophysiology. Over the last two decades, several pathogenic antibodies against neuronal surface antigens have been described in autoimmune encephalitis, which are amenable to immunotherapy. Read More

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http://dx.doi.org/10.1007/978-1-4939-9077-1_15DOI Listing
January 2019
2 Reads

Efficacy of perampanel for anti-N-methyl-D-aspartate receptor encephalitis: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14033

Rationale: We report this 1st case because perampanel may be effective against the seizures and abnormal behavior that occur in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

Patient Concerns: The patient was a healthy 26-year-old woman who suddenly developed seizures and exhibited abnormal behavior.

Diagnoses: NMDAR encephalitis was diagnosed based on positive NMDAR antibody on cerebrospinal fluid analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336627PMC
January 2019
3 Reads

Paraneoplastic neurological syndromes: a single institution 10-year case series.

J Neurooncol 2019 Jan 3;141(2):431-439. Epub 2019 Jan 3.

Department of Neurology, Yale School of Medicine, 15 York Street, LLCI 9th floor, New Haven, CT, 06510, USA.

Background: Given its rare incidence, there are few epidemiological case series on paraneoplastic neurologic syndromes (PNS).

Methods: We present a 10-year series compiled in the Section of Neuro-Oncology, Yale Cancer Center between 2002 and 2012.

Results: Twenty-five cases met the PNS Euro-network criteria for definitive PNS. Read More

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http://dx.doi.org/10.1007/s11060-018-03053-3DOI Listing
January 2019
1 Read

EEG findings in NMDA encephalitis - A systematic review.

Seizure 2019 Feb 19;65:20-24. Epub 2018 Dec 19.

University of Queensland, Brisbane, Australia; Neurology Department, Princess Alexandra Hospital, Brisbane, Australia.

Purpose: The clinical utility of EEG in cases of NMDA encephalitis is broad with many findings indicating not just epileptiform activity but also encephalopathy and potentially providing insights into pathophysiologic mechanisms of disease. We aimed to determine the frequency of different abnormalities described on EEG and their association with outcome in patients affected by NMDARE through a systematic review of all cases published.

Method: A systematic literature review of PubMed and Embase of all published cases of anti-NMDA receptor encephalitis with EEG results, was performed from inception to January 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183065
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http://dx.doi.org/10.1016/j.seizure.2018.12.015DOI Listing
February 2019
15 Reads

Diagnostic tools for immune causes of encephalitis.

Clin Microbiol Infect 2019 Apr 22;25(4):431-436. Epub 2018 Dec 22.

Division of Neurology, Department of Clinical Neuroscience, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland.

Background: Autoimmune encephalitis (AE) refers to a central nervous system (CNS) antibody-mediated entity characterized by a rapid onset behavioural and cognitive decline that can be associated with movement disorders, epileptic and dysautonomic features. Interestingly, it is thought to be as common as its infectious disease counterpart and can share some clinical, radiological, and laboratory findings.

Objectives: The aim is to describe the main clinical features of AE caused by antibodies targeting cell-surface neuronal agents and the diagnostic means to identify them. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X183080
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http://dx.doi.org/10.1016/j.cmi.2018.12.012DOI Listing
April 2019
41 Reads

Anesthesia for patient with anti-N-methyl-D-aspartate receptor encephalitis: A case report with a brief review of the literature.

Medicine (Baltimore) 2018 Dec;97(50):e13651

Department of Anesthesiology, Kyorin University School of Medicine, Shinkawa, Mitaka-shi, Tokyo, Japan.

Rationale: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an immune-mediated syndrome caused by the production of antibodies against NMDA receptors. As NMDA receptors are important targets of many anesthetic drugs, the perioperative management of patients with anti-NMDA receptor encephalitis is challenging for anesthesiologists.

Patient Concerns: A 31-year-old woman presented with akinesia and aphasia, which worsened despite steroid therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320089PMC
December 2018
3 Reads

Anti-N-methyl-D-aspartate receptor encephalitis: A case report.

Medicine (Baltimore) 2018 12;97(50):e13625

Department of Nephrology, Shandong University Qilu Hospital, Jinan, Shandong, China

Rationale: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an auto-immune and paraneoplastic encephalitis with prominent neuropsychiatric manifestations. The N-methyl-D-aspartate receptor is located in the forebrain and hippocampus and plays a role in learning and memory.

Patient Concerns: A 29-year-old female patient with anti-NMDAR encephalitis, was reported and we also reviewed the literature and summarised the characteristics of the cases. Read More

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http://dx.doi.org/10.1097/MD.0000000000013625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319820PMC
December 2018
4 Reads

Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report.

J Med Case Rep 2018 Dec 3;12(1):357. Epub 2018 Dec 3.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 301B Cyberport 4, 100 Cyberport Road, Pokfulam, Hong Kong SAR.

Background: Limbic encephalitis is characterized by rapid onset of working memory deficit, mood changes, and often seizures. The condition has a strong paraneoplastic association, but not all cases are invariably due to tumors.

Case Presentation: We present a case of limbic encephalitis in a Chinese patient who initially presented to our hospital with optic neuritis and no other neurological symptoms. Read More

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http://dx.doi.org/10.1186/s13256-018-1893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276199PMC
December 2018
5 Reads

The role of cognitive rehabilitation in limbic encephalitis: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13223

IRCCS Centro Neurolesi "Bonino-Pulejo," Messina.

Rationale: Limbic encephalitis is a parenchymal inflammation caused by viral, bacterial, or other microbial and postinfectious agents, which is usually expressed by multifocal neurological signs and cognitive impairment.

Patient Concerns: A 50-year-old female was admitted in postacute phase, at our rehabilitative Center, to undertake neuro-motor treatment for a period of 4 months.

Diagnoses: The patient was affected by limbic encephalitis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283188PMC
November 2018
12 Reads

Ictal piloerection is associated with high-grade glioma and autoimmune encephalitis-Results from a systematic review.

Seizure 2019 Jan 22;64:1-5. Epub 2018 Nov 22.

Department of Neurology, University of Pécs, H-7623, Rét u. 2., Pécs, Hungary; PTE-MTA Clinical Neuroscience MR Research Group, H-7623, Rét u. 2, Hungary. Electronic address:

Purpose: To comprehensively analyze ictal piloerection (IP) in a large number of subjects.

Methods: We performed a systematic review on case report studies of patients diagnosed with IP (1929-2017) with additional cases included from the Department of Neurology of University of Pécs, the National Institute of Clinical Neurosciences, and Odense University Hospital. Each included case was characterized regarding patient history, IP seizure characteristics, diagnostic work-up, and therapy. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.009DOI Listing
January 2019
4 Reads

[Major neurological complications of genitourinary cancers].

Rev Neurol 2018 Dec;67(11):441-452

Universidad Complutense de Madrid. Facultad de Medicina, 28040 Madrid, Espana.

Introduction: Genitourinary cancers constitute a heterogeneous and increasingly frequent group of malignant tumors that have the potential to derive directly, or indirectly from the treatment applied, in a series of neurological complications that negatively impact on the quality of life of the patients who suffer them.

Aims: To report the most relevant data on the main neurological complications of genitourinary cancers.

Development: We conducted a PubMed search for articles, latest books, leading clinical practice guidelines, and scientific societies, regarding the appearance of such complications. Read More

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December 2018
19 Reads

Clinical variability of children with anti-N-methyl-D-aspartate receptor encephalitis in southern Brazil: a cases series and review of the literature.

Neurol Sci 2019 Feb 20;40(2):351-356. Epub 2018 Nov 20.

Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

Purpose: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an immune-mediated disease of the central nervous system (CNS). The aim of this study was to describe the variability of clinical presentation in anti-NMDAR encephalitis, treatment and outcomes in a case series of children and adolescents.

Methods: Retrospectively analyse patients diagnosed with anti-NMDAR encephalitis, from 2010 to 2018. Read More

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http://dx.doi.org/10.1007/s10072-018-3648-zDOI Listing
February 2019
12 Reads

Histopathological characterization of the neuroglial tissue in ovarian teratoma associated with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis.

Pathol Int 2018 Dec 14;68(12):677-684. Epub 2018 Nov 14.

Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606-8507, Japan.

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare but occasionally fatal limbic encephalitis that may be accompanied by ovarian teratoma. Since the neuroglial tissue within the teratoma may be involved in the pathogenesis of this encephalitis, we attempted morphological and immunohistochemical characterization of the neuroglial tissue in four cases of ovarian teratoma associated with anti-NMDA receptor encephalitis and 12 control cases, i.e. Read More

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http://doi.wiley.com/10.1111/pin.12732
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http://dx.doi.org/10.1111/pin.12732DOI Listing
December 2018
11 Reads

Th17 cells were recruited and accumulated in the cerebrospinal fluid and correlated with the poor prognosis of anti-NMDAR encephalitis.

Acta Biochim Biophys Sin (Shanghai) 2018 Dec;50(12):1266-1273

Department of Neurology, Haikou People's Hospital, Haikou, China.

Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is an autoimmune disorder characterized by memory deficits, psychiatric symptoms, and autonomic instability. The lack of suitable biomarkers targeting anti-NMDAR encephalitis makes the immunotherapy and prognosis challenging. In this study, we found that the Th17 cells were significantly accumulated in the cerebrospinal fluid (CSF) of anti-NMDAR encephalitis patients than that of control individuals. Read More

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http://dx.doi.org/10.1093/abbs/gmy137DOI Listing
December 2018
4 Reads

Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.

Curr Oncol Rep 2018 Nov 10;20(11):92. Epub 2018 Nov 10.

Neurology Division, Hospital das Clínicas, University of São Paulo School of Medicine, Sao Paulo, Brazil.

The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. Read More

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http://link.springer.com/10.1007/s11912-018-0721-y
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http://dx.doi.org/10.1007/s11912-018-0721-yDOI Listing
November 2018
18 Reads

Integrated treatment for autonomic paraneoplastic syndrome improves performance status in a patient with small lung cell carcinoma: a case report.

BMC Neurol 2018 Nov 10;18(1):189. Epub 2018 Nov 10.

Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori, 030-8551, Japan.

Background: Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic and sympathetic failure. Autonomic PNS are usually associated with other PNS, such as encephalomyelitis and sensory neuropathy; however, autonomic symptoms may rarely manifest as PNS symptoms. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1192-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230283PMC
November 2018
36 Reads

The coexistence of recurrent cerebral tumefactive demyelinating lesions with longitudinally extensive transverse myelitis and demyelinating neuropathy.

Mult Scler Relat Disord 2019 Jan 3;27:223-225. Epub 2018 Nov 3.

Department of Neurology, CHU Montpellier, 80 avenue Augustin Fliche, Montpellier 34000, France.

Combined central and peripheral demyelination (CCPD) is a rare chronic inflammatory disorder of the nervous system. In this article, we report on a CCPD patient with a very unusual pattern of central demyelination, comprising recurrent cerebral tumefactive demyelinating lesions (three times, each one in a new area of the brain) and one episode of longitudinally extensive transverse myelitis. This patient could not be classified as having multiple sclerosis, or neuromyelitis optica spectrum disorder, or any other well-known inflammatory disorder of the central nervous system, associated with demyelinating neuropathy. Read More

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http://dx.doi.org/10.1016/j.msard.2018.11.002DOI Listing
January 2019

Paraneoplastic neuromyelitis optica associated with fever of unknown origin as an early manifestation: A case report.

Mult Scler Relat Disord 2019 Jan 2;27:200-202. Epub 2018 Nov 2.

Isfahan University of medical science, Isfahan, Iran.

Tumors have been frequently reported to be associated with neuromyelitis optica (NMO). Here we review a case of a 34-year-old woman who presented with complaint of one-sided visual loss. All Lab tests exhibited negative results which decreased the possibility of Auto-immune or neuro-inflammatory disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183048
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http://dx.doi.org/10.1016/j.msard.2018.10.118DOI Listing
January 2019
12 Reads

Massive idiopathic spontaneous hemothorax complicating anti-N-methyl-d-aspartate receptor encephalitis: A case report.

Medicine (Baltimore) 2018 Nov;97(45):e13188

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.

Rationale: Spontaneous hemothorax is a subcategory of hemothorax which can be life threatening. The etiology of spontaneous hemothorax can be various, and in some rare cases the causes remained unknown. Hence, it is quite difficult to establish the diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250506PMC
November 2018
24 Reads

Intrathecal formation of anticardiolipin antibodies in a patient with SLE-related relapsing longitudinal myelitis: a possible pathogenic connection.

Lupus 2018 Dec 4;27(14):2292-2295. Epub 2018 Nov 4.

1 Department of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INNSZ), Mexico City, Mexico.

Background: Nontraumatic acute transverse myelitis (ATM) can occur in response to infectious, inflammatory and vascular triggers; 1% of patients with systemic lupus erythematosus (SLE) develop ATM, but the mechanism remains unknown.

Objective: The objective of this case report is to describe a case of intrathecal formation of anticardiolipin antibodies (aCL) during SLE-related ATM.

Methods: A single patient analysis was conducted. Read More

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http://dx.doi.org/10.1177/0961203318810430DOI Listing
December 2018
22 Reads

Lambert-Eaton myasthenic syndrome associated with alemtuzumab administration.

Mult Scler Relat Disord 2019 Jan 22;27:131-132. Epub 2018 Oct 22.

Wake Forest School of Medicine, Department of Neurology, One Medical Center Blvd, Winston Salem, NC 27157, USA. Electronic address:

Background: Alemtuzumab administration is known to cause secondary autoimmune disease but has not been associated with the development of neurologic autoimmune conditions. Lambert-Eaton myasthenic syndrome (LEMS) is caused by autoantibodies directed against calcium channels on the neuromuscular junction.

Case Report: We report a case of a patient with relapsing-remitting multiple sclerosis (RRMS) treated with alemtuzumab who develop generalized weakness initially attributed to progression of MS but eventually determined to be due to LEMS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183037
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http://dx.doi.org/10.1016/j.msard.2018.10.015DOI Listing
January 2019
9 Reads

[A Case of Rectal Colon Cancer with Paraneoplastic Cerebellar Degeneration].

Gan To Kagaku Ryoho 2018 Oct;45(10):1510-1512

Dept. of Gastrointestinal Tract Surgery, Fukushima Medical University.

A case complicated with colorectal and prostate cancers in paraneoplastic(subacute)cerebellar degeneration(PCD)is extremely rare. We report a retrospective case of rectal carcinoma with paraneoplastic cerebellar degeneration. A 79-year-old man with Parkinson's disease was unable to walk because of paralysis. Read More

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October 2018
28 Reads

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases.

Mem Inst Oswaldo Cruz 2018 Oct 29;113(11):e170538. Epub 2018 Oct 29.

Instituto Evandro Chagas, Seção de Arbovirologia e Febres Hemorrágicas, Ananindeua, PA, Brasil.

This study showed that laboratory markers of recent infection by dengue, Zika or chikungunya arboviruses were detected in the biological samples of approximately one-third of patients with encephalitis, myelitis, encephalomyelitis or Guillain-Barré syndrome, in a surveillance programme in Piauí state, Brazil, between 2015-2016. Fever and myalgia had been associated with these cases. Since in non-tropical countries most infections or parainfectious diseases associated with the nervous system are attributed to herpesviruses, enteroviruses, and Campylobacter jejuni, the present findings indicate that in tropical countries, arboviruses may now play a more important role and reinforce the need for their surveillance and systematic investigation in the tropics. Read More

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http://dx.doi.org/10.1590/0074-02760170538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204615PMC
October 2018
39 Reads

Prevalence and risk factors of deep venous thrombosis in patients with longitudinally extensive transverse myelitis: one center data from China.

BMC Neurol 2018 Oct 30;18(1):179. Epub 2018 Oct 30.

Neuroinfection and Neuroimmunology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 TiantanXili, Dongcheng District, Beijing, 100050, People's Republic of China.

Objective: Deep venous thrombosis (DVT) is a severe complication in longitudinally extensive transverse myelitis (LETM) patients. It may interfere with LETM treatment and delay the recovery of the spinal dysfunction. However, there is less data about the prevalence and risk factors of DVT in patients with LETM. Read More

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http://dx.doi.org/10.1186/s12883-018-1178-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206719PMC
October 2018
2 Reads

The associations between serum vascular endothelial growth factor, tumor necrosis factor and interleukin 4 with the markers of blood-brain barrier breakdown in patients with paraneoplastic neurological syndromes.

J Neural Transm (Vienna) 2019 Feb 29;126(2):149-158. Epub 2018 Oct 29.

Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

The blood-brain barrier (BBB) disruption is a critical step in paraneoplastic neurological syndrome (PNS) development. Several cytokines have been implicated in BBB breakdown. However, the exact step-by-step mechanism in which PNS develops is unknown, and the relationship between a systemic neoplasm and BBB is multilevel. Read More

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http://dx.doi.org/10.1007/s00702-018-1950-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373237PMC
February 2019
12 Reads

[Anti-Hu antibody positive sensory neuronopathy causing painful legs and moving toes (PLMT) in a 75-year-old female with small cell lung cancer (SCLC)].

Rinsho Shinkeigaku 2018 Nov 27;58(11):677-681. Epub 2018 Oct 27.

Department of Neurology, Tokyo Teishin Hospital.

The case is a 75-year-old female. She had dysesthesia in the distal extremities and truncal ataxia, and they had progressed in two months. Neurological examination revealed the findings of segmental dysesthesia in the distal extremities, impaired deep sensations in the trunk and four limbs, and painful legs and moving toes (PLMT). Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001198DOI Listing
November 2018
1 Read

SUDEP following the second seizure in new-onset epilepsy due to limbic encephalitis.

Seizure 2018 11 10;62:124-126. Epub 2018 Oct 10.

Protestant Hospital Alsterdorf, Epilepsy Center Hamburg, Elisabeth-Flügge-Str. 1, 22337 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2018.10.007DOI Listing
November 2018
2 Reads

Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis.

Front Neurol 2018 10;9:841. Epub 2018 Oct 10.

Institute of Neurology, Medical University of Vienna, Vienna, Austria.

This review provides an overview on different antibody test methods that can be applied in cases of suspected paraneoplastic neurological syndromes (PNS) and anti-neuronal autoimmune encephalitis (AIE) in order to explain their diagnostic value, describe potential pitfalls and limitations, and discuss novel approaches aimed at discovering further autoantibodies. Onconeuronal antibodies are well-established biomarkers for PNS and may serve as specific tumor markers. The recommended procedure to detect onconeuronal antibodies is a combination of indirect immunohistochemistry on fixed rodent cerebellum and confirmation of the specificity by line assays. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00841
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http://dx.doi.org/10.3389/fneur.2018.00841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191500PMC
October 2018
33 Reads

Refractory epilepsy secondary to anti-GAD encephalitis treated with DBS post SEEG evaluation: a novel case report based on stimulation findings.

Epileptic Disord 2018 Oct;20(5):451-456

Mater Advanced Epilepsy Unit, Mater Hospital, South Brisbane, Queensland, Department of Neurology and Neurosurgery, Princess Alexandra Hospital, Woolloongabba, Queensland.

We report a case of medically refractory anti-GAD encephalitis which was treated with deep brain stimulation (DBS) after seizure termination was achieved using cortical stimulation during stereo-electroencephalography (SEEG) evaluation. The patient underwent bilateral SEEG implantation and cortical stimulation. Upon stimulation, mimicking the intrinsic seizures (at 1 Hz), it was possible to induce seizures with typical semiology, on multiple attempts. Read More

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http://dx.doi.org/10.1684/epd.2018.0993DOI Listing
October 2018
21 Reads

NMDA receptor antibody in teratoma-related opsoclonus-myoclonus syndrome.

J Clin Neurosci 2018 Dec 16;58:203-204. Epub 2018 Oct 16.

Department of Immunology, Royal Prince Alfred Hospital, Sydney, Australia.

Opsoclonus-myoclonus syndrome (OMS) is a brainstem/cerebellar syndrome producing disabling multi-directional saccadic oscillations with oscillopsia, with or without somatic myoclonus and cerebellar ataxia (Wong et al., 2001; Armangué et al., 2016). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183073
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http://dx.doi.org/10.1016/j.jocn.2018.10.011DOI Listing
December 2018
20 Reads

P/Q and N-type Voltage-gated Calcium Channel Binding Antibodies Associated with Paraneoplastic Chorea and Mixed Invasive Ductal and Lobular Carcinoma of the Breasts in an Elderly Patient.

Cureus 2018 Aug 4;10(8):e3097. Epub 2018 Aug 4.

Department of Neurology, University of Ilinois at Chicago, Chicago, USA.

Paraneoplastic neurologic syndromes are a group of immune-mediated, cancer-associated disorders affecting the nervous system. While these syndromes are not understood fully, they are reportedly caused by an immune response against common antigens expressed by the cancer and nervous system. We describe the course of a patient who suffered paraneoplastic chorea before being diagnosed with breast cancer. Read More

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http://dx.doi.org/10.7759/cureus.3097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175266PMC
August 2018
4 Reads

Mycophenolate mofetil, azathioprine and methotrexate usage in paediatric anti-NMDAR encephalitis: A systematic literature review.

Eur J Paediatr Neurol 2019 Jan 27;23(1):7-18. Epub 2018 Sep 27.

Neuroimmunology Group, Institute for Neuroscience and Muscle Research, Kids Research Institute at the Children's Hospital at Westmead, University of Sydney, Australia. Electronic address:

Background: Available data on mycophenolate mofetil (MMF), azathioprine (AZA) and methotrexate (MTX) for paediatric-onset anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is limited.

Methods: Systematic literature review on patients treated with MMF/AZA/MTX for paediatric-onset anti-NMDARE, with focus on modes of use, efficacy and safety.

Results: 87 patients were included (age at onset median 11 years, range 0. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.008DOI Listing
January 2019
11 Reads

A Case of Severe Anti-N-Methyl D-Aspartate (Anti-NMDA) Receptor Encephalitis with Refractory Autonomic Instability and Elevated Intracranial Pressure.

Am J Case Rep 2018 Oct 12;19:1216-1221. Epub 2018 Oct 12.

Department of Medicine, Division of Pulmonary and Critical Care, Riverside University Health System Medical Center, Moreno Valley, CA, USA.

BACKGROUND Anti-N-methyl D-Aspartate (anti-NMDA) receptor encephalitis is a rare autoimmune panencephalitis that typically presents with acute psychiatric disturbances and neurological deficits. Anti-NMDA receptor encephalitis is associated with certain tumors, most commonly ovarian teratomas. First-line therapy typically involves immunotherapy and tumor resection, if present, with up to 53% of patients experiencing improvement within 4 weeks. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911165
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http://dx.doi.org/10.12659/AJCR.911165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196582PMC
October 2018
3 Reads

Anti-NMDAR encephalitis complicating pregnancy.

Pract Neurol 2019 Apr 10;19(2):131-135. Epub 2018 Oct 10.

Department of Neurology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was first reported in 2005 in four patients with ovarian teratomas; there have been many further cases reported since the antigen for the NMDAR antibody was confirmed in 2007. Patients characteristically have a well-defined set of features, characterised by psychiatric disturbance, seizures and cognitive disturbance, followed by movement disorders, disorders of consciousness and dysautonomia. To date, 14 cases of NMDAR encephalitis have been described in the context of pregnancy. Read More

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http://pn.bmj.com/lookup/doi/10.1136/practneurol-2018-002042
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http://dx.doi.org/10.1136/practneurol-2018-002042DOI Listing
April 2019
8 Reads

Paraneoplastic neuronal intermediate filament autoimmunity.

Neurology 2018 Oct 3;91(18):e1677-e1689. Epub 2018 Oct 3.

From the Departments of Laboratory Medicine and Pathology (E.B., T.J.K., S.R.H., S.J.P., V.A.L., A.M.), Neurology (N.Z., Y.G., D.D., E.E.B., C.F.L., S.J.P., V.A.L., A.M.), and Immunology (V.A.L.), Mayo Clinic, Rochester, MN.

Objective: To describe paraneoplastic neuronal intermediate filament (NIF) autoimmunity.

Methods: Archived patient and control serum and CSF specimens were evaluated by tissue-based indirect immunofluorescence assay (IFA). Autoantigens were identified by Western blot and mass spectrometry. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207411PMC
October 2018
5 Reads

Neuroblastoma, opsoclonus-myoclonus ataxia syndrome and neonatal lupus with congenital heart block: is there an association?

Lupus 2018 12 3;27(14):2298-2299. Epub 2018 Oct 3.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://journals.sagepub.com/doi/10.1177/0961203318804339
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http://dx.doi.org/10.1177/0961203318804339DOI Listing
December 2018
3 Reads
2.200 Impact Factor

Thymoma and Limbic Encephalitis: A Dangerous Liaison.

Prim Care Companion CNS Disord 2018 Sep 27;20(5). Epub 2018 Sep 27.

Department of Neurology, Maltepe University, Faculty of Medicine, Istanbul, Turkey.

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http://dx.doi.org/10.4088/PCC.17l02257DOI Listing
September 2018
14 Reads

Successful treatment of paraneoplastic longitudinally extensive transverse myelitis (LETM): A 16-month clinical-spinal MRI follow-up.

Mult Scler Relat Disord 2018 Nov 22;26:207-210. Epub 2018 Sep 22.

Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia; Clinic of Neurology, Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia. Electronic address:

Longitudinally extensive transverse myelitis (LETM) is defined as a spinal cord lesion that extends over three or more vertebrae. LETM very rarely occurs in patients with the systemic malignancy. We report a 38-year old woman with adenocarcinoma of the cervix and LETM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183033
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http://dx.doi.org/10.1016/j.msard.2018.09.023DOI Listing
November 2018
4 Reads

Human herpesvirus 6 associated post-transplant acute limbic encephalitis: Clinical observations of biomarkers for risk of seizure in a pediatric population.

Transpl Infect Dis 2019 Feb 15;21(1):e13003. Epub 2018 Oct 15.

Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts.

Background: Human herpesvirus 6 (HHV6) is a cause of post-transplant acute limbic encephalitis (PALE). Seizures are associated with this disorder yet no predictive biomarkers have been identified. The objective of this study was to evaluate lab and neurodiagnostic biomarkers in patients with HHV6 associated PALE. Read More

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http://doi.wiley.com/10.1111/tid.13003
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http://dx.doi.org/10.1111/tid.13003DOI Listing
February 2019
9 Reads

Analysis of Relation Between Electroclinical Features and Cerebrospinal Fluid Antibody Titers in Patients With anti-NMDAR Encephalitis.

Clin EEG Neurosci 2019 Jan 24;50(1):56-62. Epub 2018 Sep 24.

1 Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Purpose: This study aimed to determine the relation between electroclinical features and cerebrospinal fluid (CSF) antibody titers in patients with anti- N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis.

Method: Clinical symptoms and electroencephalography (EEG) at different stages were analyzed in 51 hospitalized patients with anti-NMDAR encephalitis.

Results: Behavioral changes were the initial symptoms in 90. Read More

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http://dx.doi.org/10.1177/1550059418800867DOI Listing
January 2019
5 Reads

[Autoimmune reactions and paraneoplastic syndromes].

Radiologe 2018 Dec;58(12):1080-1090

Abteilung für Neuroradiologie, Kantonsspital Baden, Baden, Schweiz.

Clinical Issue: Autoimmune disorders of the central nervous system (CNS) are common but are also a heterogeneous group of diseases. The most common form is multiple sclerosis (MS), others are clinically isolated syndrome (CIS), acute demyelinating encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders (NMOSD). Paraneoplastic syndromes are rare and tumor-associated, they are not induced by direct invasion of tumor tissue but by tumor-associated autoantibodies mostly against specific CNS proteins, e. Read More

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http://dx.doi.org/10.1007/s00117-018-0453-xDOI Listing
December 2018
4 Reads