5,586 results match your criteria Paraneoplastic Encephalomyelitis


Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection.

Methods Mol Biol 2019 ;1941:225-255

Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to an underlying neoplasm. Some of these paraneoplastic encephalitides express serum antibodies, but these were not thought to be pathogenic but instead have a T-cell-mediated pathophysiology. Over the last two decades, several pathogenic antibodies against neuronal surface antigens have been described in autoimmune encephalitis, which are amenable to immunotherapy. Read More

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http://dx.doi.org/10.1007/978-1-4939-9077-1_15DOI Listing
January 2019
1 Read

Efficacy of perampanel for anti-N-methyl-D-aspartate receptor encephalitis: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14033

Rationale: We report this 1st case because perampanel may be effective against the seizures and abnormal behavior that occur in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

Patient Concerns: The patient was a healthy 26-year-old woman who suddenly developed seizures and exhibited abnormal behavior.

Diagnoses: NMDAR encephalitis was diagnosed based on positive NMDAR antibody on cerebrospinal fluid analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336627PMC
January 2019
1 Read

Diagnostic tools for immune causes of encephalitis.

Clin Microbiol Infect 2018 Dec 22. Epub 2018 Dec 22.

Division of Neurology, Department of Clinical Neuroscience, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland.

Background: Autoimmune encephalitis (AE) refers to a central nervous system (CNS) antibody-mediated entity characterized by a rapid onset behavioural and cognitive decline that can be associated with movement disorders, epileptic and dysautonomic features. Interestingly, it is thought to be as common as its infectious disease counterpart and can share some clinical, radiological, and laboratory findings.

Objectives: The aim is to describe the main clinical features of AE caused by antibodies targeting cell-surface neuronal agents and the diagnostic means to identify them. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X183080
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http://dx.doi.org/10.1016/j.cmi.2018.12.012DOI Listing
December 2018
21 Reads

Anesthesia for patient with anti-N-methyl-D-aspartate receptor encephalitis: A case report with a brief review of the literature.

Medicine (Baltimore) 2018 Dec;97(50):e13651

Department of Anesthesiology, Kyorin University School of Medicine, Shinkawa, Mitaka-shi, Tokyo, Japan.

Rationale: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an immune-mediated syndrome caused by the production of antibodies against NMDA receptors. As NMDA receptors are important targets of many anesthetic drugs, the perioperative management of patients with anti-NMDA receptor encephalitis is challenging for anesthesiologists.

Patient Concerns: A 31-year-old woman presented with akinesia and aphasia, which worsened despite steroid therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320089PMC
December 2018
2 Reads

Anti-N-methyl-D-aspartate receptor encephalitis: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13625

Department of Emergency, Henan Traditional Chinese Medicine Hospital, Zhengzhou, Henan.

Rationale: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an auto-immune and paraneoplastic encephalitis with prominent neuropsychiatric manifestations. The N-methyl-D-aspartate receptor is located in the forebrain and hippocampus and plays a role in learning and memory.

Patient Concerns: A 29-year-old female patient with anti-NMDAR encephalitis, was reported and we also reviewed the literature and summarised the characteristics of the cases. Read More

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http://dx.doi.org/10.1097/MD.0000000000013625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319820PMC
December 2018
2 Reads

The role of cognitive rehabilitation in limbic encephalitis: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13223

IRCCS Centro Neurolesi "Bonino-Pulejo," Messina.

Rationale: Limbic encephalitis is a parenchymal inflammation caused by viral, bacterial, or other microbial and postinfectious agents, which is usually expressed by multifocal neurological signs and cognitive impairment.

Patient Concerns: A 50-year-old female was admitted in postacute phase, at our rehabilitative Center, to undertake neuro-motor treatment for a period of 4 months.

Diagnoses: The patient was affected by limbic encephalitis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283188PMC
November 2018
5 Reads

Ictal piloerection is associated with high-grade glioma and autoimmune encephalitis-Results from a systematic review.

Seizure 2019 Jan 22;64:1-5. Epub 2018 Nov 22.

Department of Neurology, University of Pécs, H-7623, Rét u. 2., Pécs, Hungary; PTE-MTA Clinical Neuroscience MR Research Group, H-7623, Rét u. 2, Hungary. Electronic address:

Purpose: To comprehensively analyze ictal piloerection (IP) in a large number of subjects.

Methods: We performed a systematic review on case report studies of patients diagnosed with IP (1929-2017) with additional cases included from the Department of Neurology of University of Pécs, the National Institute of Clinical Neurosciences, and Odense University Hospital. Each included case was characterized regarding patient history, IP seizure characteristics, diagnostic work-up, and therapy. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.009DOI Listing
January 2019
3 Reads

[Major neurological complications of genitourinary cancers].

Rev Neurol 2018 Dec;67(11):441-452

Universidad Complutense de Madrid. Facultad de Medicina, 28040 Madrid, Espana.

Introduction: Genitourinary cancers constitute a heterogeneous and increasingly frequent group of malignant tumors that have the potential to derive directly, or indirectly from the treatment applied, in a series of neurological complications that negatively impact on the quality of life of the patients who suffer them.

Aims: To report the most relevant data on the main neurological complications of genitourinary cancers.

Development: We conducted a PubMed search for articles, latest books, leading clinical practice guidelines, and scientific societies, regarding the appearance of such complications. Read More

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December 2018
10 Reads

Histopathological characterization of the neuroglial tissue in ovarian teratoma associated with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis.

Pathol Int 2018 Dec 14;68(12):677-684. Epub 2018 Nov 14.

Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606-8507, Japan.

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare but occasionally fatal limbic encephalitis that may be accompanied by ovarian teratoma. Since the neuroglial tissue within the teratoma may be involved in the pathogenesis of this encephalitis, we attempted morphological and immunohistochemical characterization of the neuroglial tissue in four cases of ovarian teratoma associated with anti-NMDA receptor encephalitis and 12 control cases, i.e. Read More

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http://doi.wiley.com/10.1111/pin.12732
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http://dx.doi.org/10.1111/pin.12732DOI Listing
December 2018
10 Reads

Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.

Curr Oncol Rep 2018 Nov 10;20(11):92. Epub 2018 Nov 10.

Neurology Division, Hospital das Clínicas, University of São Paulo School of Medicine, Sao Paulo, Brazil.

The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. Read More

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http://link.springer.com/10.1007/s11912-018-0721-y
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http://dx.doi.org/10.1007/s11912-018-0721-yDOI Listing
November 2018
12 Reads

Integrated treatment for autonomic paraneoplastic syndrome improves performance status in a patient with small lung cell carcinoma: a case report.

BMC Neurol 2018 Nov 10;18(1):189. Epub 2018 Nov 10.

Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori, 030-8551, Japan.

Background: Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic and sympathetic failure. Autonomic PNS are usually associated with other PNS, such as encephalomyelitis and sensory neuropathy; however, autonomic symptoms may rarely manifest as PNS symptoms. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1192-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230283PMC
November 2018
15 Reads

Massive idiopathic spontaneous hemothorax complicating anti-N-methyl-d-aspartate receptor encephalitis: A case report.

Medicine (Baltimore) 2018 Nov;97(45):e13188

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.

Rationale: Spontaneous hemothorax is a subcategory of hemothorax which can be life threatening. The etiology of spontaneous hemothorax can be various, and in some rare cases the causes remained unknown. Hence, it is quite difficult to establish the diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250506PMC
November 2018
17 Reads

Intrathecal formation of anticardiolipin antibodies in a patient with SLE-related relapsing longitudinal myelitis: a possible pathogenic connection.

Lupus 2018 Dec 4;27(14):2292-2295. Epub 2018 Nov 4.

1 Department of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INNSZ), Mexico City, Mexico.

Background: Nontraumatic acute transverse myelitis (ATM) can occur in response to infectious, inflammatory and vascular triggers; 1% of patients with systemic lupus erythematosus (SLE) develop ATM, but the mechanism remains unknown.

Objective: The objective of this case report is to describe a case of intrathecal formation of anticardiolipin antibodies (aCL) during SLE-related ATM.

Methods: A single patient analysis was conducted. Read More

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http://dx.doi.org/10.1177/0961203318810430DOI Listing
December 2018
15 Reads

[A Case of Rectal Colon Cancer with Paraneoplastic Cerebellar Degeneration].

Gan To Kagaku Ryoho 2018 Oct;45(10):1510-1512

Dept. of Gastrointestinal Tract Surgery, Fukushima Medical University.

A case complicated with colorectal and prostate cancers in paraneoplastic(subacute)cerebellar degeneration(PCD)is extremely rare. We report a retrospective case of rectal carcinoma with paraneoplastic cerebellar degeneration. A 79-year-old man with Parkinson's disease was unable to walk because of paralysis. Read More

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October 2018
20 Reads

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases.

Mem Inst Oswaldo Cruz 2018 Oct 29;113(11):e170538. Epub 2018 Oct 29.

Instituto Evandro Chagas, Seção de Arbovirologia e Febres Hemorrágicas, Ananindeua, PA, Brasil.

This study showed that laboratory markers of recent infection by dengue, Zika or chikungunya arboviruses were detected in the biological samples of approximately one-third of patients with encephalitis, myelitis, encephalomyelitis or Guillain-Barré syndrome, in a surveillance programme in Piauí state, Brazil, between 2015-2016. Fever and myalgia had been associated with these cases. Since in non-tropical countries most infections or parainfectious diseases associated with the nervous system are attributed to herpesviruses, enteroviruses, and Campylobacter jejuni, the present findings indicate that in tropical countries, arboviruses may now play a more important role and reinforce the need for their surveillance and systematic investigation in the tropics. Read More

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http://dx.doi.org/10.1590/0074-02760170538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204615PMC
October 2018
31 Reads

Prevalence and risk factors of deep venous thrombosis in patients with longitudinally extensive transverse myelitis: one center data from China.

BMC Neurol 2018 Oct 30;18(1):179. Epub 2018 Oct 30.

Neuroinfection and Neuroimmunology Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 TiantanXili, Dongcheng District, Beijing, 100050, People's Republic of China.

Objective: Deep venous thrombosis (DVT) is a severe complication in longitudinally extensive transverse myelitis (LETM) patients. It may interfere with LETM treatment and delay the recovery of the spinal dysfunction. However, there is less data about the prevalence and risk factors of DVT in patients with LETM. Read More

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http://dx.doi.org/10.1186/s12883-018-1178-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206719PMC
October 2018
1 Read

The associations between serum vascular endothelial growth factor, tumor necrosis factor and interleukin 4 with the markers of blood-brain barrier breakdown in patients with paraneoplastic neurological syndromes.

J Neural Transm (Vienna) 2019 Feb 29;126(2):149-158. Epub 2018 Oct 29.

Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

The blood-brain barrier (BBB) disruption is a critical step in paraneoplastic neurological syndrome (PNS) development. Several cytokines have been implicated in BBB breakdown. However, the exact step-by-step mechanism in which PNS develops is unknown, and the relationship between a systemic neoplasm and BBB is multilevel. Read More

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http://dx.doi.org/10.1007/s00702-018-1950-9DOI Listing
February 2019
3 Reads

[Anti-Hu antibody positive sensory neuronopathy causing painful legs and moving toes (PLMT) in a 75-year-old female with small cell lung cancer (SCLC)].

Rinsho Shinkeigaku 2018 Nov 27;58(11):677-681. Epub 2018 Oct 27.

Department of Neurology, Tokyo Teishin Hospital.

The case is a 75-year-old female. She had dysesthesia in the distal extremities and truncal ataxia, and they had progressed in two months. Neurological examination revealed the findings of segmental dysesthesia in the distal extremities, impaired deep sensations in the trunk and four limbs, and painful legs and moving toes (PLMT). Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001198DOI Listing
November 2018
1 Read

SUDEP following the second seizure in new-onset epilepsy due to limbic encephalitis.

Seizure 2018 11 10;62:124-126. Epub 2018 Oct 10.

Protestant Hospital Alsterdorf, Epilepsy Center Hamburg, Elisabeth-Flügge-Str. 1, 22337 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2018.10.007DOI Listing
November 2018
1 Read

Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis.

Front Neurol 2018 10;9:841. Epub 2018 Oct 10.

Institute of Neurology, Medical University of Vienna, Vienna, Austria.

This review provides an overview on different antibody test methods that can be applied in cases of suspected paraneoplastic neurological syndromes (PNS) and anti-neuronal autoimmune encephalitis (AIE) in order to explain their diagnostic value, describe potential pitfalls and limitations, and discuss novel approaches aimed at discovering further autoantibodies. Onconeuronal antibodies are well-established biomarkers for PNS and may serve as specific tumor markers. The recommended procedure to detect onconeuronal antibodies is a combination of indirect immunohistochemistry on fixed rodent cerebellum and confirmation of the specificity by line assays. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00841
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http://dx.doi.org/10.3389/fneur.2018.00841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191500PMC
October 2018
19 Reads

Refractory epilepsy secondary to anti-GAD encephalitis treated with DBS post SEEG evaluation: a novel case report based on stimulation findings.

Epileptic Disord 2018 Oct;20(5):451-456

Mater Advanced Epilepsy Unit, Mater Hospital, South Brisbane, Queensland, Department of Neurology and Neurosurgery, Princess Alexandra Hospital, Woolloongabba, Queensland.

We report a case of medically refractory anti-GAD encephalitis which was treated with deep brain stimulation (DBS) after seizure termination was achieved using cortical stimulation during stereo-electroencephalography (SEEG) evaluation. The patient underwent bilateral SEEG implantation and cortical stimulation. Upon stimulation, mimicking the intrinsic seizures (at 1 Hz), it was possible to induce seizures with typical semiology, on multiple attempts. Read More

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http://dx.doi.org/10.1684/epd.2018.0993DOI Listing
October 2018
12 Reads

NMDA receptor antibody in teratoma-related opsoclonus-myoclonus syndrome.

J Clin Neurosci 2018 Dec 16;58:203-204. Epub 2018 Oct 16.

Department of Immunology, Royal Prince Alfred Hospital, Sydney, Australia.

Opsoclonus-myoclonus syndrome (OMS) is a brainstem/cerebellar syndrome producing disabling multi-directional saccadic oscillations with oscillopsia, with or without somatic myoclonus and cerebellar ataxia (Wong et al., 2001; Armangué et al., 2016). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183073
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http://dx.doi.org/10.1016/j.jocn.2018.10.011DOI Listing
December 2018
12 Reads

P/Q and N-type Voltage-gated Calcium Channel Binding Antibodies Associated with Paraneoplastic Chorea and Mixed Invasive Ductal and Lobular Carcinoma of the Breasts in an Elderly Patient.

Cureus 2018 Aug 4;10(8):e3097. Epub 2018 Aug 4.

Department of Neurology, University of Ilinois at Chicago, Chicago, USA.

Paraneoplastic neurologic syndromes are a group of immune-mediated, cancer-associated disorders affecting the nervous system. While these syndromes are not understood fully, they are reportedly caused by an immune response against common antigens expressed by the cancer and nervous system. We describe the course of a patient who suffered paraneoplastic chorea before being diagnosed with breast cancer. Read More

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http://dx.doi.org/10.7759/cureus.3097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175266PMC
August 2018
2 Reads

Paraneoplastic neuronal intermediate filament autoimmunity.

Neurology 2018 Oct 3;91(18):e1677-e1689. Epub 2018 Oct 3.

From the Departments of Laboratory Medicine and Pathology (E.B., T.J.K., S.R.H., S.J.P., V.A.L., A.M.), Neurology (N.Z., Y.G., D.D., E.E.B., C.F.L., S.J.P., V.A.L., A.M.), and Immunology (V.A.L.), Mayo Clinic, Rochester, MN.

Objective: To describe paraneoplastic neuronal intermediate filament (NIF) autoimmunity.

Methods: Archived patient and control serum and CSF specimens were evaluated by tissue-based indirect immunofluorescence assay (IFA). Autoantigens were identified by Western blot and mass spectrometry. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207411PMC
October 2018
4 Reads

Neuroblastoma, opsoclonus-myoclonus ataxia syndrome and neonatal lupus with congenital heart block: is there an association?

Lupus 2018 12 3;27(14):2298-2299. Epub 2018 Oct 3.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://journals.sagepub.com/doi/10.1177/0961203318804339
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http://dx.doi.org/10.1177/0961203318804339DOI Listing
December 2018
2 Reads
2.200 Impact Factor

Thymoma and Limbic Encephalitis: A Dangerous Liaison.

Prim Care Companion CNS Disord 2018 Sep 27;20(5). Epub 2018 Sep 27.

Department of Neurology, Maltepe University, Faculty of Medicine, Istanbul, Turkey.

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http://dx.doi.org/10.4088/PCC.17l02257DOI Listing
September 2018
12 Reads

[Autoimmune reactions and paraneoplastic syndromes].

Radiologe 2018 Dec;58(12):1080-1090

Abteilung für Neuroradiologie, Kantonsspital Baden, Baden, Schweiz.

Clinical Issue: Autoimmune disorders of the central nervous system (CNS) are common but are also a heterogeneous group of diseases. The most common form is multiple sclerosis (MS), others are clinically isolated syndrome (CIS), acute demyelinating encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders (NMOSD). Paraneoplastic syndromes are rare and tumor-associated, they are not induced by direct invasion of tumor tissue but by tumor-associated autoantibodies mostly against specific CNS proteins, e. Read More

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http://dx.doi.org/10.1007/s00117-018-0453-xDOI Listing
December 2018
3 Reads

The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review.

Can J Neurol Sci 2018 09;45(5):577-579

2Department of Pathology and Laboratory Medicine,London Health Sciences Centre,London,Ontario,Canada.

Paraneoplastic syndromes (PNS) are immune-mediated neurologic diseases that occur as an indirect effect of malignancy, and can be challenging to diagnose. Onconeural antibodies have a greater than 95% association with cancer, and their presence in a patient with neurologic symptoms is reportedly highly indicative of PNS. However, we performed a single-centre retrospective review to determine the positive predictive value of onconeural antibody testing, and found it to be concerningly low (39%). Read More

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http://dx.doi.org/10.1017/cjn.2018.74DOI Listing
September 2018
3 Reads

Movement disorders in autoimmune encephalitis and paraneoplastic neurological syndromes.

Rev Neurol (Paris) 2018 Nov 7;174(9):597-607. Epub 2018 Sep 7.

Hospices Civils de Lyon, Centre de Référence Maladies Rares Syndromes Neurologiques Paranéoplasiques, Hôpital Neurologique, Neurologie B, 59, boulevard Pinel, 69677 Bron, France; INMG (NeuroMyoGene Institute) Inserm U1217/CNRS UMR 5310, 8, avenue Rockfeller, 69372 Lyon, France; Université de Lyon, Université Claude Bernard Lyon 1, 8, avenue Rockfeller, 69372 Lyon, France.

Movement disorders are extremely common and diverse in autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS). They can sometimes represent the main neurological disorder of a given patient, or just be part of a larger neurological syndrome. Early diagnosis of AE or PNS is essential, as the associated abnormal movements can be effectively treated with immunomodulators. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00353787183076
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http://dx.doi.org/10.1016/j.neurol.2018.07.006DOI Listing
November 2018
16 Reads

Affinities of human NMDA receptor autoantibodies: implications for disease mechanisms and clinical diagnostics.

J Neurol 2018 Nov 5;265(11):2625-2632. Epub 2018 Sep 5.

German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common autoimmune encephalitis presenting with psychosis, dyskinesias, autonomic dysfunction and seizures. The underlying autoantibodies against the NR1 subunit are directly pathogenic by disrupting synaptic NMDAR currents. However, antibody titers correlate only partially with the clinical outcome, suggesting the relevance of other factors such as antibody affinity. Read More

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http://dx.doi.org/10.1007/s00415-018-9042-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182686PMC
November 2018
1 Read

Limbic encephalitis associated with antibodies against the α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid receptor: a case report.

Neuro Endocrinol Lett 2018 05;39(2):85-87

Department of Neurology, The First Hospital, Jilin University, Changchun, China.

We report a case of a 51-year-old man with limbic encephalitis (LE) associated with antibodies against the α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid receptor (AMPAR). The patient presented with anterograde memory loss for 2 months. Cranial magnetic resonance and electroencephalogram were normal. Read More

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May 2018
3 Reads

Enigmatic entities: opsoclonus myoclonus ataxia syndrome linked to neuroblastoma.

Lancet Child Adolesc Health 2018 01 4;2(1):3-5. Epub 2017 Nov 4.

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23524642173012
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http://dx.doi.org/10.1016/S2352-4642(17)30129-3DOI Listing
January 2018
2 Reads

Primary Epstein-Barr virus infection in immunocompetent patients with acute transverse myelitis and a combination of polyradiculitis and anterior horn syndrome as neurological manifestations.

BMJ Case Rep 2018 Aug 29;2018. Epub 2018 Aug 29.

Department of Neurology, Tergooi, Blaricum, The Netherlands.

Neurological manifestations of a primary Epstein-Barr virus (EBV) infection are rare. We describe a case with acute transverse myelitis and another case with a combination of polyradiculitis and anterior horn syndrome as manifestations of a primary EBV infection.The first case is a 50-year-old immunocompetent male diagnosed with acute transverse myelitis, 2 weeks after he was clinically diagnosed with infectious mononucleosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-225333DOI Listing
August 2018
3 Reads

Thyroid Function and Autoimmune Indications in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

Neuroimmunomodulation 2018 29;25(2):110-117. Epub 2018 Aug 29.

Objective: Previous studies have shown that functional abnormalities of the thyroid are associated with the pathogenesis of several neurological diseases. However, their relationship in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis remains to be defined.

Methods: Forty-three patients with anti-NMDAR encephalitis were examined for thyroid function and autoimmune indications, in comparison with 225 healthy controls (CTL). Read More

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http://dx.doi.org/10.1159/000492179DOI Listing
January 2019
2 Reads
1.880 Impact Factor

Case 27-2018: A 3-Year-Old Boy with Seizures.

N Engl J Med 2018 Aug;379(9):870-878

From the Department of Neurology, Boston Children's Hospital (M.P.G.), the Departments of Neurology (G.Y.G., R.L.T.), Radiology (W.A.M.), and Pediatrics (R.L.T.), Massachusetts General Hospital, and the Departments of Neurology (M.P.G., G.Y.G., R.L.T.) and Radiology (W.A.M.), Harvard Medical School - all in Boston.

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http://www.nejm.org/doi/10.1056/NEJMcpc1802824
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http://dx.doi.org/10.1056/NEJMcpc1802824DOI Listing
August 2018
10 Reads

Ovarian Teratoma or Uterine Malformation? PET/MRI as a Novel Useful Tool in NMDAR Encephalitis.

In Vivo 2018 Sep-Oct;32(5):1231-1233

Neurology Unit, Ospedale Sant'Antonio, Padua, Italy.

This is a case report of a 17-year-old girl affected by N-methyl-D-aspartate-receptor (NMDAR) encephalitis suspected for a paraneoplastic syndrome. Ultrasound (US) and computed tomography (CT) imaging identified an ovarian lesion compatible with teratoma. F-fluorodeoxyglucose (FDG) positron emission tomography/magnetic resonance imaging (PET/MRI), performed to evaluate metabolic activity of the brain and of the ovarian mass, correctly changed the diagnosis to uterine malformation that was later histologically proven. Read More

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http://dx.doi.org/10.21873/invivo.11369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199583PMC
December 2018

Paraneoplastic cerebellar degeneration as a manifestation of metastatic recurrent carcinoma breast: rare scenario.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Surgery, All India Institute of Medical Sciences, New Delhi, India.

Carcinoma breast presenting with paraneoplastic cerebellar degeneration is a rare scenario. We report a case of a 52-year-old woman, which is a follow-up case of completely treated carcinoma breast presenting with paraneoplastic cerebellar degeneration which, on investigation, revealed metastatic disease with recurrence at previous scar site and metastasis to contralateral axilla. The patient was given pulse methyl prednisolone therapy and underwent wide local excision of nodule and right axillary lymph node dissection with 14 cycles of trastuzumab and paclitaxel as adjuvant therapy. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22257
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http://dx.doi.org/10.1136/bcr-2017-222575DOI Listing
August 2018
12 Reads

Identifying optic neuritis and transverse myelitis using administrative data.

Mult Scler Relat Disord 2018 Oct 13;25:258-264. Epub 2018 Aug 13.

Medicine (Neurology), University of British Columbia and The Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. Electronic address:

Objective: We aimed to validate administrative case definitions to identify individuals with optic neuritis (ON) or transverse myelitis (TM), and to distinguish which of these individuals had a monophasic presentation versus multiple sclerosis (MS).

Methods: Using population-based administrative (health claims) data from Manitoba, Canada, we developed case definitions for ON and TM, and distinguished individuals who had monophasic presentations (ON-nonMS, TM-nonMS) versus those later diagnosed with MS (ON-MS, TM-MS). We compared performance of these case definitions to diagnoses based on medical records review in a reference cohort (n = 1251) using sensitivity, specificity, positive predictive value and negative predictive value. Read More

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http://dx.doi.org/10.1016/j.msard.2018.08.013DOI Listing
October 2018
11 Reads

Autopsy-proven case of paraneoplastic lower motor neuron disease with sensorimotor neuropathy due to Waldenström's macroglobulinemia.

Neuropathology 2018 Oct 19;38(5):568-573. Epub 2018 Aug 19.

Department of Neurology, Asahikawa Medical Center, Asahikawa, Japan.

We report a case of a male patient with a 19-year history of monoclonal and later polyclonal gammopathy who subsequently developed tetraparesis, bulbar palsy, and respiratory failure. Autopsy findings showed degeneration of the hypoglossal nuclei, prominent neuronal loss and atrophy in the anterior horn of the whole spinal cord despite the presence of mild astrocytosis, degeneration of the gracilis on one side, and infiltration of inflammatory cells, which included B cells and plasma cells in the anterior and posterior roots of the lumbar spinal cord, iliopsoas muscle, and perivascular area of the cervical cord. On immunostaining, cytoplasmic inclusions of phosphorylated transactivation response DNA-binding protein of 43 kDa were observed in the motor neurons and astrocytes of the hypoglossal nuclei and whole spinal cord. Read More

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http://dx.doi.org/10.1111/neup.12506DOI Listing
October 2018
4 Reads

Two Case Reports of Neuropsychological Outcomes following Pediatric anti-N-methyl D-aspartate Receptor Autoimmune Encephalitis.

Dev Neuropsychol 2018 10;43(7):656-668. Epub 2018 Aug 10.

c Department of Psychiatry and Behavioral Sciences , University of New Mexico Health Sciences Center , Albuquerque , New Mexico , USA.

Anti-NMDAR autoimmune encephalitis is a rare neurological condition. Limited existing pediatric case studies have shown mild, but persisting, neuropsychological impairments. This report described neuropsychological functioning in two patients treated for anti-NMDAR autoimmune encephalitis. Read More

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http://dx.doi.org/10.1080/87565641.2018.1506456DOI Listing
January 2019
2 Reads

Lambert-Eaton Myasthenic Syndrome Associated With Extrapulmonary Small Cell Cancer Detected by 18F-FDG PET/CT.

Clin Nucl Med 2018 Sep;43(9):697-698

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

A 46-year-old woman suffering from lower extremity weakness, dysarthria, dysphagia, dyspnea, and dry mouth was suspected of having Lambert-Eaton myasthenic syndrome based on the characteristic electromyographic abnormalities of right ulnar nerve, which demonstrated reduced resting compound muscle action potential amplitude and greater than 100% incremental change in high-frequency repetitive nerve stimulation. An F-FDG PET/CT was performed to detect the underlying neoplasm and revealed a retroperitoneal soft tissue mass with high F-FDG avidity in the left iliac fossa. The patient's symptoms were prominently relieved after the tumor resection, and the histopathology indicated a small cell carcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002192DOI Listing
September 2018
3 Reads

Opsoclonus-myoclonus-ataxia syndrome associated with chikungunya and dengue virus co-infection.

Int J Infect Dis 2018 Oct 1;75:11-14. Epub 2018 Aug 1.

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, Bahia, Brazil. Electronic address:

Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare neurological disorder characterized by irregular multidirectional eye movements, myoclonus, cerebellar ataxia, sleep disturbances, and cognitive dysfunction. Although most commonly related to paraneoplastic syndrome, this condition has occasionally been described following infectious illnesses. This article reports the first case of OMAS in association with chikungunya and dengue virus co-infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183448
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http://dx.doi.org/10.1016/j.ijid.2018.07.019DOI Listing
October 2018
10 Reads

Successful treatment of anti-NMDA receptor encephalitis with early teratoma removal and plasmapheresis: A case report.

Medicine (Baltimore) 2018 Aug;97(31):e11325

Department of Obstetrics and Gynecology, University Clinic Hospital of Salamanca, Salamanca.

Rationale: This report describes a Successful treatment of anti-NMDA receptor encephalitis with early teratoma removal and plasmapheresis.

Patient Concerns: We present a 31-year-old Caucasian nulliparous patient who was admitted as an emergency with general illness status accompanied by holocranial cephalalgia and fever.

Diagnoses: The previous symptoms were followed by disorientation, persecutory delusion, incoherent language, and tonic-clonic seizure. Read More

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http://dx.doi.org/10.1097/MD.0000000000011325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081068PMC
August 2018
4 Reads

A case of anti-MOG antibody-positive unilaterally dominant meningoencephalitis followed by longitudinally extensive transverse myelitis.

Mult Scler Relat Disord 2018 Oct 26;25:128-130. Epub 2018 Jul 26.

Department of Neurology, Hiroshima City Hiroshima Citizens Hospital, 7-33 Motomachi, Naka-ku, Hiroshima 730-8518, Japan.

Background: There are few reports of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive, unilaterally dominant cerebral cortical encephalitis onset with epilepsy. We present such a case in a young female patient with myelitis.

Case Presentation: A 19-year-old female developed generalized tonic seizures lasting several minutes. Read More

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http://dx.doi.org/10.1016/j.msard.2018.07.028DOI Listing
October 2018
2 Reads

Anti-NMDA Receptor Encephalitis in a Young Girl with Altered Behaviour and Abnormal Movements.

J Coll Physicians Surg Pak 2018 Aug;28(8):643-644

Department of Neurology, Pakistan Institute of Medical Sciences (PIMS), SZAMBU, Islamabad.

Autoimmune encephalitis is a rare central nervous system disorder in which the patient presents with neuropsychiatric symptoms. We herein present a case of anti-NMDA receptor encephalitis in which the patient initially presented in the psychiatric department. A 14-year girl was brought with complains of irritability, altered behaviour, abnormal movements, self biting, and decreased sleep for the past 10 days. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.08.643DOI Listing
August 2018
1 Read

[Myelitis transversa caused by neuroschistosomiasis].

Ned Tijdschr Geneeskd 2018 May 3;162. Epub 2018 May 3.

Rijnstate, afd. Interne Geneeskunde, Arnhem.

Background: Neuroschistosomiasis is a severe complication of an infection with Schistosoma; this infection can lead to myelitis transversa. Acute myelitis transversa is a rare disorder of the spinal cord, which can present with muscular weakness, sensory disturbance and intestinal or bladder dysfunction.

Case Description: A 17-year-old refugee from Eritrea, who had been in the Netherlands for 3 weeks, suffered from back pain and progressive weakness of both legs for one week. Read More

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May 2018
3 Reads

[Anti-NMDAR encephalitis as a serious adverse event probably related to yellow fever vaccination].

Klin Mikrobiol Infekc Lek 2018 03;24(1):17-19

Clinic of infectious medicine, Clinic of neurology, Blood centre, Faculty Hospital Ostrava, Czech Republic, e-mail:

We present a case of a 17-year-old female with anti-NMDAR encephalitis probably associated with vaccination against yellow fever. Her symptoms occurred 27 days after vaccination against yellow fever. Anti-NMDAR encephalitis manifested as acute psychosis, memory loss and catatonia following fever with complex partial epileptic seizures. Read More

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March 2018
3 Reads

Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis.

Mult Scler Relat Disord 2018 Oct 10;25:21-25. Epub 2018 Jul 10.

Neuroimmunological Disorders Gene-Environment Epidemiology Laboratory, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, United States. Electronic address:

Background: Cardiovascular conditions are associated with poorer outcomes in multiple sclerosis (MS). Whether the burden of cardiovascular conditions differs between those with demyelinating disease and unaffected controls is not clear. The objective of this study is to investigate the burden and age of onset of cardiovascular conditions in a US population with MS, neuromyelitis optica spectrum disorder (NMOSD), or transverse myelitis (TM) to unaffected controls adjusting for likely confounders. Read More

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http://dx.doi.org/10.1016/j.msard.2018.07.011DOI Listing
October 2018
2 Reads

Pathogenic Mechanisms and Clinical Correlations in Autoimmune Myasthenic Syndromes.

Semin Neurol 2018 06 16;38(3):344-354. Epub 2018 Jul 16.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Autoimmune myasthenic syndromes are antibody-mediated disorders of the neuromuscular junction. Common antigenic targets are the acetylcholine receptor or muscle specific kinase (MuSK) in myasthenia gravis (MG) and the voltage-gated calcium channel in Lambert-Eaton myasthenic syndrome. There is evidence that antibodies directed against other antigens such as low-density lipoprotein receptor-related protein 4 (LRP4) are also involved in MG. Read More

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http://dx.doi.org/10.1055/s-0038-1660500DOI Listing
June 2018
16 Reads

Limbic encephalitis associated with systemic sclerosis.

Mult Scler Relat Disord 2018 Aug 10;24:142-144. Epub 2018 Jul 10.

Division of Neurology, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland.

We report the case of a patient affected by systemic sclerosis (SSc) who developed autoimmune limbic encephalitis, which improved under immunosuppressant agents and high-dose intravenous immunoglobulins. In our patient the autoimmune encephalitis occurred during apparently quiescent SSc, though concomitantly with novel arthritis. Moreover, our patient showed auto-antibodies directed against SSA antigen but the panel of auto-antibodies associated with autoimmune encephalitis was negative. Read More

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http://dx.doi.org/10.1016/j.msard.2018.06.019DOI Listing
August 2018
5 Reads