20,549 results match your criteria Paraneoplastic Encephalomyelitis


Pathophysiology of paraneoplastic and autoimmune encephalitis: genes, infections, and checkpoint inhibitors.

Ther Adv Neurol Disord 2020 24;13:1756286420932797. Epub 2020 Jun 24.

Centre de Référence National pour les Syndromes Neurologiques Paranéoplasiques, Hôpital Neurologique, 59 Boulevard Pinel, Bron Cedex, 69677, France.

Paraneoplastic neurological syndromes (PNSs) are rare complications of systemic cancers that can affect all parts of the central and/or peripheral nervous system. A body of experimental and clinical data has demonstrated that the pathogenesis of PNSs is immune-mediated. Nevertheless, the mechanisms leading to immune tolerance breakdown in these conditions remain to be elucidated. Read More

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http://dx.doi.org/10.1177/1756286420932797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318829PMC

[Virus-induced opsoclonus-myoclonus syndrome during pregnancy].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):93-99

Almazov National Medical Research Centre, St. Petersburg, Russia.

Opsoclonus-myoclonus syndrome (OMS) is a very rare condition with various etiologies (paraneoplastic, parainfectious, toxic, idiopathic, etc.) with an autoimmune pathogenetic mechanism of development. The authors describe the case of OMS in a 41-year-old woman at 37 weeks of gestation, who developed opsoclonus, myoclonus, severe trunk ataxia, tremor and bilateral pyramidal symptoms, inability to sit, stand and walk without support. Read More

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http://dx.doi.org/10.17116/jnevro202012005193DOI Listing

[Research progress on electroencephalogram characteristics of anti-N-methyl-D-aspartate receptor encephalitis].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 May;49(1):118-123

The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a kind of autoimmune disease aiming at NR1 subunit of NMDA receptor. In the early stage, functional damage is the main cause. Electroencephalogram (EEG) can reflect the abnormal brain function by recording the changes of EEG signals. Read More

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[Cryptococcal Encephalitis Complicating Anti-N-methyl-D-aspartate Receptor Encephalitis in an Immunosuppressed Patient].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):417-420

Department of Geriatric Neurology,Xiangya Hospital,Central South University,Changsha 410008,China.

Cryptococcal encephalitis is a fatal central nervous system infectious disease,whereas anti-N-methyl-D-aspartate(NMDA)receptor encephalitis(NMDARE)is an autoimmune syndrome associated with psychological symptoms,behavioural abnormalities,seizures,and dyskinesias.Despite their distinct pathologies and pathogenic mechanisms,both of them can lead to cognitive dysfunction and abnormal behaviors,although anti-NMDARE can also have mood and mental disorders as its core manifestations.A patient with nephrotic syndrome accompanied by both cryptococcal encephalitis and anti-NMDARE was treated in our center,which for the first confirmed that these two conditions could coexist in one patient. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11472DOI Listing

[Research Advances in Follicular Regulatory T Cells in Ocular Myasthenia Gravis].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):383-387

Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China.

Myasthenia gravis(MG)is a B cell-mediated,T cell-dependent,complements-involved autoimmune disease.Ocular myasthenia gravis(OMG)is a typical MG,with its symptoms limited to the extraocular muscles.The occurrence and development of a variety of autoimmune diseases including OMG are closely associated with the imbalanced expression of follicular regulatory T cells(Tfr cells). Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.11252DOI Listing

COVID-19-associated acute necrotizing myelitis.

Neurol Neuroimmunol Neuroinflamm 2020 09 10;7(5). Epub 2020 Jun 10.

From the Neurology Department (J.S.) and Radiology Department (Y.R.-Á.), Hospital Universitari Mútua Terrassa, Spain.

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http://dx.doi.org/10.1212/NXI.0000000000000803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309521PMC
September 2020

COVID-19 in Refractory Myasthenia Gravis- A Case Report of Successful Outcome.

J Neuromuscul Dis 2020 ;7(3):361-364

Department of Neurology, University of Missouri, Columbia, Missouri.

This is a brief report of a patient who has refractory Myasthenia Gravis, on multiple long-term immunosuppressive therapies and contracted COVID-19 during this 2020 pandemic. She was quarantined for total of 14 days and recovered successfully without any complications (no myasthenia exacerbation or crisis, no COVID-19 related complications), with no changes to her immunosuppressive therapy. Treatment of MG patients with COVID-19 needs to be tailored to individual patient. Read More

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http://dx.doi.org/10.3233/JND-200520DOI Listing

Neurological Syndromes Associated with Anti-GAD Antibodies.

Int J Mol Sci 2020 May 24;21(10). Epub 2020 May 24.

AP-HP, Groupe Hospitalier Pitié-Salpêtrière, service de Neurologie 2-Mazarin, 75013 Paris, France.

Glutamic acid decarboxylase (GAD) is an intracellular enzyme whose physiologic function is the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter within the central nervous system. GAD antibodies (Ab) have been associated with multiple neurological syndromes, including stiff-person syndrome, cerebellar ataxia, and limbic encephalitis, which are all considered to result from reduced GABAergic transmission. The pathogenic role of GAD Ab is still debated, and some evidence suggests that GAD autoimmunity might primarily be cell-mediated. Read More

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http://dx.doi.org/10.3390/ijms21103701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279468PMC

Anti-NMDA receptor encephalitis in a psychiatric Covid-19 patient: A case report.

Brain Behav Immun 2020 07 23;87:179-181. Epub 2020 May 23.

Department of Mental Health and Addiction Services, Niguarda Hospital, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2020.05.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255176PMC

Acute disseminated encephalomyelitis associated with a novel paraneoplastic process in hepatic epithelial hemangioendothelioma: A case report.

Clin Neurol Neurosurg 2020 Jul 12;194:105903. Epub 2020 May 12.

Department of Neurosurgery, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2020.105903DOI Listing

Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis.

Gene 2020 Aug 19;752:144774. Epub 2020 May 19.

Department of Translational Research and of New Surgical and Medical Technologies, Lab. of Medical Genetics, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy; Department of Laboratory Medicine, Pisa University Hospital, Pisa, Italy.

Background: Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation levels in thymic epithelial tumors, and particularly in thymomas from patients with Myasthenia Gravis (TAMG).

Material And Methods: In the present study we collected DNA samples from circulating lymphocytes and surgically resected tumor tissues of 65 TAMG patients, and from the adjacent healthy thymic tissue available from 43 of them. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144774DOI Listing

Myasthenic crisis in COVID-19.

J Neurol Sci 2020 07 6;414:116888. Epub 2020 May 6.

Department of Neurology, Wayne State University and Detroit Medical Center, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2020.116888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200364PMC

Paraneoplastic Encephalomyelitis With Glutamic Acid Decarboxylase Antibodies Presenting as Longitudinal Pyramidal Tract Hyperintensity.

JAMA Neurol 2020 May 11. Epub 2020 May 11.

Neuro-Oncology Unit, Neurology Department, Hospital Universitari de Bellvitge-Institut Català d´Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1001/jamaneurol.2020.0940DOI Listing

Neurological Implications of COVID-19 Infections.

Neurocrit Care 2020 06;32(3):667-671

Division of Anaesthesia, University of Cambridge, Cambridge, UK.

The magnitude of the COVID-19 pandemic will result in substantial neurological disease, whether through direct infection (rare), para-infectious complications (less rare), or critical illness more generally (common). Here, we raise the importance of stringent diagnosis and data collection regarding neurological complications of COVID-19; we urge caution in the over-diagnosis of neurological disease where it does not exist, but equally strongly encourage the concerted surveillance for such conditions. Additional to the direct neurological complications of COVID-19 infection, neurological patients are at risk of harm from both structural limitations (such as number of intensive care beds), and a hesitancy to treat with certain necessary medications given risk of nosocomial COVID-19 infection. Read More

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http://dx.doi.org/10.1007/s12028-020-00978-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188454PMC

Mild Encephalitis/Encephalopathy with reversible splenial lesion syndrome: An unusual presentation of anti-GFAP astrocytopathy.

Eur J Paediatr Neurol 2020 May 18;26:89-91. Epub 2020 Mar 18.

Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital Bicêtre, Pediatric Neurology Department, National Referral Center for Rare Inflammatory Brain and Spinal Diseases, France; Université Paris-Sud, UMR 1184-CEA-IDMIT, Center for Immunology of Viral Infections and Autoimmune Diseases, 94275, Le Kremlin Bicêtre, France. Electronic address:

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a rare recently defined antibody-mediated encephalitis. Meningo-encephalomyelitis presentation is frequent with lymphocytic pleiocytosis in the cerebro-spinal fluid and brain MRI classically demonstrates in 50% of cases, a linear perivascular enhancement extending radially from the ventricles. Here, we describe 2 cases of pediatric autoimmune GFAP astrocytopathy with limbic encephalitis presentation and peculiar MRI characteristics: one with normal MRI and the second suggestive of Mild Encephalitis/Encephalopathy with reversible splenial lesion syndrome (MERS). Read More

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http://dx.doi.org/10.1016/j.ejpn.2020.03.002DOI Listing

Acupuncture for ocular myasthenia gravis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Apr;99(17):e19901

The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Background: The aim of this systematic review with meta-analysis is to determine the efficacy and security of acupuncture in treatment of ocular myasthenia gravis and find out whether or not the quick short-term efficacy of acupuncture exists.

Methods: The following electronic databases will be searched by 2 independent reviewers: PubMed, Cochrane Library, EMBASE, Springer, China National Knowledge Infrastructure, Wanfang, and Chinese Biomedical Literature Database. All randomized controlled trials on acupuncture for ocular myasthenia gravis published in electronic databases from inception to March 1, 2020, with language restricted in Chinese and English will be included in the study. Read More

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http://dx.doi.org/10.1097/MD.0000000000019901DOI Listing
April 2020
5.723 Impact Factor

Risk factors for pneumonia in patients with anti-NMDA receptor encephalitis: A single-center retrospective study.

Medicine (Baltimore) 2020 Apr;99(17):e19802

Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan.

To identify the risk factors of pneumonia in patients with Anti-N-methyl-D-aspartate (Anti-NMDA) receptor encephalitis.This is a retrospective study.Department of Neurology in West China Hospital of Sichuan University. Read More

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http://dx.doi.org/10.1097/MD.0000000000019802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220633PMC

[Review of correlation between human parvovirus B19 and autoimmune disease etiology].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 Jan;36(1):75-80

Department of Pathology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China. *Corresponding author, E-mail:

Human parvovirus B19 (PVB19) is a small single strand DNA virus distributed throughout the world, with its encoded products being three known proteins. There is conclusive evidence that PVB19 infection is a crucial inducement of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Hashimoto's thyroiditis (HT), myasthenia gravis (MG) and other autoimmune diseases (AIDs). Recent studies have confirmed that anti-B19-VP1u-IgG antibody is able to increase the activity of cytokines such as interleukin 1 (IL-1), tumor necrosis factor α (TNF-α), matrix metalloproteinase-9 (MMP9); PVB19 protein NS 1 and VP1u are capable of inducing the expression of IL-6; PVB19 can induce the production of Th17 cell-related cytokines, resulting in the decrease of IFN-gamma levels and the increase of IL-4 levels in plasma. Read More

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January 2020

Central nervous system complications associated with immune checkpoint inhibitors.

J Neurol Neurosurg Psychiatry 2020 07 20;91(7):772-778. Epub 2020 Apr 20.

Centre National de Référence pour les Syndromes Neurologiques Paranéoplasiques, Hospices Civils de Lyon, Lyon, France

Objective: To describe the spectrum and outcome of central nervous system complications associated with immune checkpoint inhibitors (CNS-ICI).

Methods: Patients with CNS-ICI were identified and their characteristics compared with ICI-related peripheral neuropathy (PN-ICI).

Results: We identified 19 patients with CNS-ICI. Read More

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http://dx.doi.org/10.1136/jnnp-2020-323055DOI Listing

Acupuncture can serve at most only as supplementary therapy for myasthenia gravis.

Authors:
Josef Finsterer

Ann Palliat Med 2020 05 13;9(3):1278-1279. Epub 2020 Apr 13.

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria.

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http://dx.doi.org/10.21037/apm.2020.04.07DOI Listing

Ptosis that resolves with application of an ice pack.

BMJ 2020 Apr 16;369:m1147. Epub 2020 Apr 16.

Milton Keynes University Hospital, Milton Keynes, UK.

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http://dx.doi.org/10.1136/bmj.m1147DOI Listing

Concomitant Guillain-Barré Syndrome and Acute Transverse Myelitis in an Older Adult-A Case Report.

Acta Neurol Taiwan 2020 Mar;29(1):12-17

Department of Neurology, Chang Gung Memorial Hospital, Keelung branch, Taiwan.

Purpose: Guillain-Barré syndrome concomitant with spinal cord involvement, which is defined as Guillain-Barré syndrome and acute transverse myelitis overlap syndrome, is rarely seen in the elders. Here we present a 68-year-old female patient who developed Guillain-Barré syndrome, as well as acute transverse myelitis at the same episode.

Case Report: This patient developed acute weakness of lower limbs, which then rapidly became tetraplegia and hyporeflexia within 5 days. Read More

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COVID-19 and neuromuscular disorders.

Neurology 2020 06 13;94(22):959-969. Epub 2020 Apr 13.

From the Division of Neuromuscular Medicine, Department of Neurology, Massachusetts General Hospital (A.C.G.), and Division of Neuromuscular Medicine, Department of Neurology, Brigham and Woman's Hospital (A.A.A.), Harvard Medical School, Boston, MA.

The coronavirus 2019 (COVID-19) pandemic has potential to disproportionately and severely affect patients with neuromuscular disorders. In a short period of time, it has already caused reorganization of neuromuscular clinical care delivery and education, which will likely have lasting effects on the field. This article reviews (1) potential neuromuscular complications of COVID-19, (2) assessment and mitigation of COVID-19-related risk for patients with preexisting neuromuscular disease, (3) guidance for management of immunosuppressive and immunomodulatory therapies, (4) practical guidance regarding neuromuscular care delivery, telemedicine, and education, and (5) effect on neuromuscular research. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009566DOI Listing

Myasthenic crisis and late deep vein thrombosis following thymectomy in a patient with myasthenia gravis: A case report.

Medicine (Baltimore) 2020 Apr;99(15):e19781

Department of Anesthesiology, Chi Mei Medical Center, Tainan.

Introduction: Surgical stress and pain are potential provoking factors for postoperative myasthenic crisis (POMC). We report the occurrence of early POMC and late deep vein thrombosis (DVT) in a man with myasthenia gravis (MG) undergoing thymectomy, addressing possible link between reversal of opioid overdose with naloxone and the triggering of POMC.

Patient Concerns: A 71-year-old man with impaired renal function (ie, estimated glomerular filtration rate [egfr]: 49. Read More

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http://dx.doi.org/10.1097/MD.0000000000019781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220329PMC
April 2020
5.723 Impact Factor

LncRNA XLOC_003810 promotes T cell activation and inhibits PD-1/PD-L1 expression in patients with myasthenia gravis-related thymoma.

Scand J Immunol 2020 Jul 27;92(1):e12886. Epub 2020 Apr 27.

Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

This study aimed to investigate the effect of long non-coding RNA XLOC_003810 on the activation of CD4 T cells and expression of PD-1/PD-L1 in patients with myasthenia gravis-related thymoma (MG-T). Thymus specimens and thymic mononuclear cells were obtained from MG and MG-T patients or cardiac surgery patients undergoing thoracotomy who were selected as negative controls (NC). XLOC_003810 expression was examined using quantitative real-time PCR (qRT-PCR). Read More

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http://dx.doi.org/10.1111/sji.12886DOI Listing

Multiple intracranial lesions with lung adenocarcinoma: A rare case of MOG-IgG-associated encephalomyelitis.

Mult Scler Relat Disord 2020 Jul 21;42:102064. Epub 2020 Mar 21.

Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha, China. Electronic address:

Background: Myelin oligodendrocyte glycoprotein (MOG) is an important marker on the surface of oligodendrocytes and is associated with many demyelinating diseases. Recently, MOG-IgG-associated encephalomyelitis (MOG-EM) has been proposed as a disease entity with a preliminary diagnosis standard. Some patients with lung cancer have been reported to be seropositive for onconeural antibodies; however, lung cancer cases with MOG-EM have not been previously reported. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102064DOI Listing

[Overlapping syndrome of myelin oligodendrocyte glycoprotein-antibody disease and anti-N-methyl-D-aspartate receptor encephalitis in two children].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):324-326

Department of Neurology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China.

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http://dx.doi.org/10.3760/cma.j.cn112140-20190916-00588DOI Listing

Paraneoplastic Diseases of the Central Nervous System.

F1000Res 2020 6;9. Epub 2020 Mar 6.

Department of Neurology, University of Utah, Salt Lake City, UT, 84108, USA.

Paraneoplastic neurological syndromes are nonmetastatic complications of malignancy secondary to immune-mediated neuronal dysfunction or death. Pathogenesis may occur from cell surface binding of antineuronal antibodies leading to dysfunction of the target protein, or from antibodies binding against intracellular antigens which ultimately leads to cell death. There are several classical neurological paraneoplastic phenotypes including subacute cerebellar degeneration, limbic encephalitis, encephalomyelitis, and dorsal sensory neuropathy. Read More

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http://dx.doi.org/10.12688/f1000research.21309.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062203PMC

Clinical characteristics of antiNmethylaspartate receptor encephalitis in children.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Jan;45(1):47-54

Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objectives: To analyze the clinical characteristics and prognosis of children with anti-N-methyl--aspartate receptor (NMDAR) encephalitis and to provide a basis for early clinical identification of this disease.

Methods: The clinical data of 42 cases of anti-NMDAR encephalitis at Department of Pediatrics, Second Xiangya Hospital, Central South University from January 2015 to March 2018 were collected. The clinical features and followed-up outcomes were analyzed retrospectively. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180761DOI Listing
January 2020

Associations between HLA and autoimmune neurological diseases with autoantibodies.

Auto Immun Highlights 2020 Jan 22;11(1). Epub 2020 Jan 22.

French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 59 Boulevard Pinel, 69677, Bron Cedex, France.

Recently, several autoimmune neurological diseases have been defined by the presence of autoantibodies against different antigens of the nervous system. These autoantibodies have been demonstrated to be specific and useful biomarkers, and most of them are also pathogenic. These aspects have increased the value of autoantibodies in neurological practice, as they enable to establish more accurate diagnosis and to better understand the underlying mechanisms of the autoimmune neurological diseases when they are compared to those lacking them. Read More

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http://dx.doi.org/10.1186/s13317-019-0124-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065322PMC
January 2020

Extreme delta brush patterns guide the complex motor phenomenon of anti-NMDA receptor encephalitis: A case report.

Medicine (Baltimore) 2020 Feb;99(9):e19384

Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation.

Rationale: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disease that is associated with cell-surface NMDAR-targeting autoantibodies. Typical anti-NMDAR encephalitis symptoms include psychosis, seizure and extrapyramidal side effects. However, early diagnosis of anti-NMDAR encephalitis remains challenging due to the complexity of the motor phenomenon. Read More

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http://dx.doi.org/10.1097/MD.0000000000019384DOI Listing
February 2020

[Impetiginized, erosive plaques in a man with myasthenia gravis].

Hautarzt 2020 Jun;71(6):479-481

Klinik für Dermatologie, Kantonsspital Aarau, Aarau, Schweiz.

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http://dx.doi.org/10.1007/s00105-020-04559-6DOI Listing

[Acute neuropsychiatry: a confused patient and a puzzled doctor].

Ned Tijdschr Geneeskd 2019 12 5;163. Epub 2019 Dec 5.

Universitair Medisch Centrum Groningen, Afd. Psychiatrie, Groningen.

Background: Anti-NMDA-receptor-encephalitis is a progressive autoimmune disease with significant mortality if left untreated.

Case Description: A 58-year-old man without previous psychiatric or neurologic history presented at the emergency department after brief loss of consciousness at work. Within a few hours, the patient developed acute neuropsychiatric symptoms, including altered levels of consciousness, aggression, incoherence, change in behaviour, and psychomotor agitation. Read More

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December 2019

Muscle involvement in myasthenia gravis: Expanding the clinical spectrum of Myasthenia-Myositis association from a large cohort of patients.

Autoimmun Rev 2020 Apr 14;19(4):102498. Epub 2020 Feb 14.

Neuromuscular and Rare Disease Center, Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), SAPIENZA University, Sant'Andrea Hospital, Rome, Italy.

Myastenia-Inflammatory Myopathy (MG-IM) association has been described in less than 50 cases, as isolated reports or in few case series. In most cases, MG and IM onset occur simultaneously even if the overlapping clinical manifestations could lead to delay the diagnosis in the early stage of disease. In these cases, thymic pathology is present in more than 50% of cases. Read More

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http://dx.doi.org/10.1016/j.autrev.2020.102498DOI Listing

Worsening of anti-Hu paraneoplastic neurological syndrome related to anti-PD-1 treatment: Case report and review of literature.

J Neuroimmunol 2020 Apr 3;341:577184. Epub 2020 Feb 3.

Division of Neurology, Lahey Hospital & Medical Center, Burlington, MA, United States of America; Tufts University School of Medicine, Boston, MA, United States of America.

We present an illustrative case of a 62-year-old woman with small cell lung cancer who developed progressive worsening of pre-existing anti-Hu antibody associated sensory neuronopathy after treatment with programmed cell death-1 (PD-1) inhibitor, nivolumab. We review the literature and identify 6 reported cases to understand the clinical outcomes of patients with anti-Hu paraneoplastic neurologic syndrome (PNS) treated with anti-PD-1 treatment. The PNS clinical spectrum comprised of encephalitis, a combination of sensory neuronopathy and anti-NMDAR encephalitis, isolated sensory neuronopathy, and encephalomyelitis. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577184DOI Listing
April 2020
2.467 Impact Factor

Myasthenia gravis, Guillain-Barré syndrome, or both?

Ideggyogy Sz 2020 Jan;73(1-2):60-64

Department of Neurology, University of Pamukkale, Denizli, Turkey.

Myasthenia gravis (MG) and Guillain-Barré syndrome (GBS) are autoimmune disorders that may cause weakness in the extremities. The coexistence of MG and GBS in the same patient has rarely been reported previously. A 52-year-old male presenting with ptosis of the left eye that worsened with fatigue, especially toward evening, was evaluated in our outpatient department. Read More

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http://dx.doi.org/10.18071/isz.73.0060DOI Listing
January 2020

[Myasthenia gravis. Register of 190 cases in a single center].

Medicina (B Aires) 2020 ;80(1):10-16

División Neurología, Hospital General de Agudos Dr. José María Ramos Mejía, Centro Argentino de Neuroinmunología, CADENI, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction. The aim of this study was to evaluate clinical, epidemiological and serological features of patients with MG in a Public Hospital of Buenos Aires City. A retrospective analysis of 190 patients diagnosed with MG was performed. Read More

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Anti-CV2/CRMP5 antibody-associated hemorrhagic leukoencephalomyelitis treated with steroids, intravenous immunoglobulin, plasmapheresis, and cyclophosphamide.

Mult Scler Relat Disord 2020 May 22;40:101964. Epub 2020 Jan 22.

Department of Neurology, Memorial University of Newfoundland, Newfoundland and Labrador, 300 Prince Phillip Drive, St. John's A1B 3V6, Canada.

Anti-CV2 or anti-collapsing response-mediator protein-5 (CRMP5) autoantibodies (anti-CV2/CRMP5-Ab) are associated with various paraneoplastic neurological disorders. The best therapy is typically removal of the underlying cancer. We describe a previously healthy elderly male who had no known malignancy. Read More

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http://dx.doi.org/10.1016/j.msard.2020.101964DOI Listing

Lower number of plasma exchange sessions and glomerular filtration rate decline are associated with second relapses in patients with myasthenia gravis.

Medicine (Baltimore) 2020 Feb;99(6):e19100

Department of Nephrology, Hypertension, Dialysis and Transplantation.

The aims were to determine the impact of dysphagia and glomerular filtration rate (GFR) in the prediction of myasthenia relapse and analyse whether different number of plasma exchange sessions could prolong the time before future relapse.This was a retrospective, longitudinal follow-up study with 60 enrolled patients. The patients were followed-up for a total of 50 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000019100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015643PMC
February 2020

Dopaminergic Hyperactivity in Neurological Patients with Delirium.

Arch Med Res 2019 11 1;50(8):477-483. Epub 2020 Feb 1.

Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, Mexico. Electronic address:

Background: Delirium has important etiological, prognostic, and therapeutic implications. The study of neurochemical markers in this condition is relevant to the understanding of its pathophysiology. The assessment of the dopamine system is particularly relevant, as dopamine antagonists are the most used drugs in delirium. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.11.002DOI Listing
November 2019

Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat.

Open Vet J 2019 10 29;9(3):246-252. Epub 2019 Aug 29.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.

Background: Cerebellar cortical degeneration (CCD) is the premature death of cerebellar neurons of heterogeneous etiology that is uncommonly observed as a neurological complication of certain neoplasia.

Case Description: Here, we report an 8-month-old male domestic cat with altered consciousness, symmetric ataxia, hypermetric gait, vertical positional nystagmus, mydriasis, strabismus, intention tremor of the head, and increased patellar reflexes. Neuroanatomical diagnosis suggested a multifocal brain dysfunction (cerebellar and cerebral). Read More

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http://dx.doi.org/10.4314/ovj.v9i3.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794398PMC
October 2019

Seizures in patients with cancer.

Cancer 2020 Apr 22;126(7):1379-1389. Epub 2020 Jan 22.

Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.

Seizures are common in patients with cancer and either result from brain lesions, paraneoplastic syndromes, and complications of cancer treatment or are provoked by systemic illness (metabolic derangements, infections). Evaluation should include a tailored history, neurologic examination, laboratory studies, neuroimaging, and electroencephalogram. In unprovoked seizures, antiepileptic drug (AED) treatment is required, and a nonenzyme-inducing AED is preferred. Read More

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http://dx.doi.org/10.1002/cncr.32708DOI Listing

18F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis.

PLoS One 2020 17;15(1):e0227906. Epub 2020 Jan 17.

Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Introduction: Limbic encephalitis (LE) is an immune-related, sometimes paraneoplastic process of the central nervous system. Initial diagnosis and treatment are based on the clinical presentation as well as antibody profiles and MRI. This study investigated the diagnostic value of integrated 18F-FDG-PET/MRI in the diagnostic work-up of patients with LE for a cerebral and whole-body imaging concept. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227906PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968877PMC

Anti-leucine-rich Glioma Inactivated-1 Encephalitis Associated with Essential Thrombocythemia.

Intern Med 2020 15;59(2):271-275. Epub 2020 Jan 15.

Department of Neurology, Liaocheng People's Hospital; Liaocheng Clinical School, Taishan Medical University, PR China.

Anti-leucine-rich glioma inactivated-1 (anti-LGI1) encephalitis is a subgroup of autoimmune encephalitis. We herein report the case of a 60-year-old man who presented with typical symptoms, including short-term memory loss, mental abnormalities, hyponatremia and seizures characterized by faciobrachial dystonic seizures and who was diagnosed with anti-LGI1 encephalitis. At the same time, he was diagnosed with essential thrombocythemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.2963-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008042PMC

Transverse Myelitis and Guillain-Barré Syndrome Overlap Secondary to Bartonella henselae: Case Report.

Prague Med Rep 2019 ;120(4):131-137

Department of Medicine and Department of Neurology, Federal University of Santa Maria, Santa Maria, Brasil.

The GBS/ATM overlap is characterized by the simultaneous occurrence of Guillain-Barré syndrome (GBS) and acute transverse myelitis (ATM), which are two neurological autoimmune disorders. In this context, cat scratch disease (CSD) was rarely reported combined with this overlap. An adult female presenting fever, back pain, inferior limb weakness, and anuria was admitted to our hospital. Read More

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http://dx.doi.org/10.14712/23362936.2019.18DOI Listing
January 2020

[Anti-NMDAR encephalitis associated with relapsing optic neuritis: a case report and differential diagnosis].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(10. Vyp. 2):137-146

Pirogov National Russian Scientific Medical University, Moscow, Russia; Federal Center of Cerebrovascular Pathology and Stroke, Moscow, Russia.

Autoimmune encephalitis with antibodies to NMDA receptors, or anti-NMDAR encephalitis, is the most common form of autoimmune encephalitis. The disease is curable, however, the lack of timely therapy can lead to the disability of patients or to the death. Difficulties in the diagnosis of anti-NMDAR encephalitis are caused by the heterogeneity of its manifestations, a possible overlapping with other autoimmune diseases and insufficient awareness about this form of encephalitis. Read More

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http://dx.doi.org/10.17116/jnevro201911910137DOI Listing
February 2020

Neurological complications of pediatric cancer.

Cancer Metastasis Rev 2020 Mar;39(1):3-23

Department of Neurology, Johns Hopkins Hospital, 200 N Wolfe St Suite 2158, Baltimore, MD, 21287, USA.

Both the onset of various malignancies as well as the treatment of cancer can lead to neurologic symptoms which can be difficult to diagnose. In this review, we highlight the varied ways in which neurologic sequelae of cancer and its treatment manifest in children. Initial neurologic presentation may be secondary to mass effect or to immune-mediated paraneoplastic syndromes. Read More

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http://dx.doi.org/10.1007/s10555-020-09847-0DOI Listing

Myasthenic crises triggering Takotsubo cardiomyopathy.

Int J Cardiol 2020 02;300:48

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2019.11.084DOI Listing
February 2020

Reply to: Myasthenic crises triggering Takotsubo cardiomyopathy.

Int J Cardiol 2020 02;300:47

Division of Cardiology, Atlanta VA Medical Center, Decatur, GA, USA; Division of Cardiology, Emory University School of Medicine, Decatur, GA, USA.

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http://dx.doi.org/10.1016/j.ijcard.2019.11.112DOI Listing
February 2020