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    6108 results match your criteria Paraneoplastic Diseases

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    [Paraneoplastic syndromes in rheumatology].
    Internist (Berl) 2018 Jan 16. Epub 2018 Jan 16.
    Rheumaeinheit, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Pettenkoferstr. 8a, 80336, München, Deutschland.
    Malignancies can present as inflammatory rheumatic diseases. These rheumatic paraneoplastic syndromes are rare, but characteristic in their pattern. This article focuses on epidemiology, clinical and diagnostic features as well as treatment of paraneoplasic rheumatic diseases such as paraneoplastic arthritides, vasculitides, myositis and hypertrophic osteoarthropathy. Read More

    Autoimmune retinopathy: A Review.
    Int J Retina Vitreous 2018 3;4. Epub 2018 Jan 3.
    Federal University of São Paulo, Rua Botucatu 821, Vila Clementino, São Paulo, SP CEP: 04023-062 Brazil.
    Autoimmune retinopathy (AIR) is a rare and still poorly understood immune-mediated disease that may cause inflammation from circulating autoantibodies against the retina. It may be related to history of autoimmune disease in the patient or in a family member or the presence of neoplastic disease in the individual. The disease may be subdivided into paraneoplastic and non-paraneoplastic AIR. Read More

    Pregnant Lady With Undiagnosed Hodgkin's Disease Presenting As Secondary Sclerosing Cholangitis.
    J Ayub Med Coll Abbottabad 2017 Oct-Dec;29(4):684-685
    Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.
    Hodgkin's lymphoma. A 25 years old lady, 34 weeks primigravida was referred from the Emergency Department to the Medical Unit Khyber Teaching Hospital-MTI, Peshawar with four weeks of fever, progressive jaundice, pruritus, night sweats and weight loss. LFTs showed cholestatic picture, ERCP showed scanty intrahepatic giving beading and autumn tree appearance typical of sclerosing cholangitis. Read More

    [Rheumatoid symptoms in patients with hematologic neoplasms].
    Z Rheumatol 2017 Oct;76(Suppl 2):38-45
    Praxiszentrum St Bonifatius, München, Deutschland.
    Paraneoplastic syndromes in lymphatic or myeloid neoplasms can present with musculoskeletal symptoms, vasculitis-like or febrile symptoms. Hematologic diseases are also associated with rheumatic diseases whereas inflammatory rheumatic diseases are often associated with an increased risk for lymphoproliferative disease. Atypical disease characteristics, lack of disease-specific antibodies or therapeutic response are red flags for diagnosing paraneoplastic or coexistent malignant diseases. Read More

    [Paraneoplastic neurological syndromes : A current summary].
    Internist (Berl) 2018 Jan 11. Epub 2018 Jan 11.
    Klinisches Institut für Neurologie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
    Background: Paraneoplastic neurological syndromes (PNNS) are remote effects of a tumor and mediated by an altered immune reaction. In the last ten years, the spectrum of PNNS has changed profoundly with the discovery of a new category of neurological diseases that are associated with antibodies against surface or synaptic antigens. In contrast to classical PNNS, patients with surface receptor autoimmunity are often highly responsive to immunotherapy. Read More

    [Paraneoplasms of the skin].
    Internist (Berl) 2018 Jan 10. Epub 2018 Jan 10.
    Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Deutschland.
    The cutaneous manifestations of malignancies include nonmalignant skin disorders that occur in association with malignancies (facultative paraneoplastic dermatoses) and skin disorders that are always associated with hematologic diseases or solid tumors (obligate paraneoplastic dermatoses). Paraneoplastic increase of growth factors or immunological reactions lead to a variety of inflammatory, hyperkeratotic or proliferative skin reactions. When paraneoplastic dermatoses develop before cancer is diagnosed, recognition of these skin diseases can accelerate both the diagnosis and treatment. Read More

    Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model.
    Front Endocrinol (Lausanne) 2017 19;8:358. Epub 2017 Dec 19.
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, United States.
    Muscle weakness and cachexia are significant paraneoplastic syndromes of many advanced cancers. Osteolytic bone metastases are common in advanced breast cancer and are a major contributor to decreased survival, performance, and quality of life for patients. Pathologic fracture caused by osteolytic cancer in bone (OCIB) leads to a significant (32%) increased risk of death compared to patients without fracture. Read More

    Assessment of neuronal autoantibodies in patients with small cell lung cancer treated with chemotherapy with or without ipilimumab.
    Oncoimmunology 2018 27;7(2):e1395125. Epub 2017 Nov 27.
    Cancer Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
    Small-cell lung cancer (SCLC) is often associated with paraneoplastic syndromes. To assess the role of anti-neuronal autoantibodies (NAAs) as biomarkers of treatment outcome, we assessed NAAs in serial samples from SCLC patients treated with chemoimmunotherapy compared to chemotherapy alone. We evaluated 2 cohorts: in cohort 1 (C1), 47 patients received standard platinum/etoposide, and in cohort 2 (C2), 38 patients received ipilimumab, carboplatin and etoposide. Read More

    Neurolymphomatosis of the Brachial Plexus and its Branches: Case Series and Literature Review.
    Can J Neurol Sci 2018 Jan 8:1-7. Epub 2018 Jan 8.
    2Ottawa Hospital Research Institute,Ottawa,Ontario,Canada.
    Background: Neurolymphomatosis is a process of neoplastic endoneurial invasion, most strongly associated with non-Hodgkin's lymphoma. It must be distinguished from paraneoplastic, metabolic, nutritional and treatment-related causes of neuropathy that are common in this patient population.

    Methods: This brief case series illustrates the protean manifestations of neurolymphomatosis of the brachial plexus, ranging from focal distal mononeuropathy to multifocal brachial plexopathy, either as the index manifestation of lymphoma or as a complication of relapsing disease. Read More

    Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies.
    J Neuroimmunol 2018 Feb 18;315:28-32. Epub 2017 Dec 18.
    Center for Sleep Sciences and Medicine, Stanford University, 3165 Porter Drive, Palo Alto, CA 94304, USA. Electronic address:
    Anti-Yo paraneoplastic cerebellar degeneration (PCD) is a devastating autoimmune complication of gynecological cancers. We hypothesized that as for other autoimmune diseases, specific HLA haplotypes are associated. We conducted high resolution HLA typing of Class I/Class II in 40 cases versus ethnically matched controls. Read More

    Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis.
    Int J Mol Sci 2018 Jan 1;19(1). Epub 2018 Jan 1.
    Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (38), Riyadh 11461, Saudi Arabia.
    Thyroid hormone is a potent stimulator of metabolism, playing a critical role in regulating energy expenditure and in key physiological mechanisms, such as growth and development. Although administration of thyroid hormone in the form of levo thyroxine (l-thyroxine) has been used to treat hypothyroidism for many years, the precise molecular basis of its physiological actions remains uncertain. Our objective was to define the changes in circulating protein levels that characterize alterations in thyroid hormone status. Read More

    Genetic alterations and tumor immune attack in Yo paraneoplastic cerebellar degeneration.
    Acta Neuropathol 2018 Jan 3. Epub 2018 Jan 3.
    Institut NeuroMyogène, Equipe Synaptopathies et Autoanticorps (SynatAc), INSERM U1217/UMR CRS 5310, Lyon, France.
    Paraneoplastic cerebellar degenerations with anti-Yo antibodies (Yo-PCD) are rare syndromes caused by an auto-immune response against neuronal antigens (Ags) expressed by tumor cells. However, the mechanisms responsible for such immune tolerance breakdown are unknown. We characterized 26 ovarian carcinomas associated with Yo-PCD for their tumor immune contexture and genetic status of the 2 onconeural Yo-Ags, CDR2 and CDR2L. Read More

    Principles and approaches to the treatment of immune-mediated movement disorders.
    Eur J Paediatr Neurol 2017 Dec 19. Epub 2017 Dec 19.
    The Children's Hospital at Westmead Clinical School, Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Australia; Brain and Mind Centre Westmead, University of Sydney, Australia. Electronic address:
    Immune mediated movement disorders include movement disorders in the context of autoimmune encephalitis such as anti-NMDAR encephalitis, post-infectious autoimmune movement disorders such as Sydenham chorea, paraneoplastic autoimmune movement disorders such as opsoclonus myoclonus ataxia syndrome, and infection triggered conditions such as paediatric acute neuropsychiatric syndrome. This review focuses on the approach to treatment of immune mediated movement disorders, which requires an understanding of the immunopathogenesis, whether the disease is destructive or 'altering', and the natural history of disease. Factors that can influence outcome include the severity of disease, the delay before starting therapy, use of multimodal therapy and whether the course is monophasic or relapsing. Read More

    A Review of Women's Neurology.
    Am J Med 2017 Dec 27. Epub 2017 Dec 27.
    Brigham and Women's Hospital, Department of Neurology. 60 Fenwood Road; Boston, MA 02115,. Electronic address:
    The concern about what is best practice when caring for women with neurologic disease is a common clinical scenario. Therefore, knowledge about women's health issues and their intersection with neurologic disorders is imperative. This review will discuss the appropriate gender based considerations in epilepsy, multiple sclerosis, migraine, autoimmune disease, sleep, stroke and paraneoplastic disorders. Read More

    F18-fluorodeoxyglucose positron emission tomography/computed tomography for bone hemangiopericytoma.
    Mol Clin Oncol 2017 Dec 18;7(6):1147-1151. Epub 2017 Oct 18.
    Department of Radiology, Nuclear Medicine Section, Rutgers New Jersey Medical School, University Hospital, Newark, NJ 07103, USA.
    Bone hemangiopericytoma (HPC) is extremely rare, and its clinical manifestations and radiographic features are nonspecific. There are few case reports about application of F18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in HPC. A total of four subjects with pathologically diagnosed bone HPC had FDG PET/CT for staging and/or restaging bone HPC. Read More

    Minimal Change Disease as Initial Presentation of ALK-Positive Anaplastic Large-Cell Lymphoma in a Pediatric Patient.
    Case Rep Oncol 2017 Sep-Dec;10(3):964-972. Epub 2017 Nov 6.
    Division of Nephrology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.
    The association between nephrotic syndrome (NS), hemophagocytic lymphohistiocytosis (HLH), and certain paraneoplastic syndromes has been documented in the literature. However, nephrotic changes as part of paraneoplastic syndromes are rare in lymphoid malignancies, particularly in non-Hodgkin lymphoma. We report the sudden onset of acute renal failure and NS in a 14-year-old male who initially presented with HLH and was subsequently diagnosed with ALK-positive anaplastic large-cell lymphoma (ALCL). Read More

    Paraneoplastic Auto-immune Hemolytic Anemia: An Unusual Sequela of Enteric Duplication Cyst.
    Anticancer Res 2018 01;38(1):509-512
    Department of Hematology and Oncology, Lehigh Valley Health Network, John and Dorothy Morgan Cancer Center, Allentown, PA, U.S.A.
    Enteric duplication (ED) cysts are rare congenital anomalies of the alimentary canal that present in childhood. Although benign in most case, ED cysts have the potential to cause complications including a rare association with secondary carcinomas. Autoimmune hemolytic anemia presenting as a paraneoplastic syndrome secondary to solid tumors is an unusual phenomenon. Read More

    A Case of Paraneoplastic Limbic Encephalitis in a Patient with Invasive Thymoma with Anti-Glutamate Receptor Antibody-Positive Cerebrospinal Fluid: A Case Report.
    Ann Thorac Cardiovasc Surg 2017 Dec 20. Epub 2017 Dec 20.
    Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
    Background: Thymoma is known to cause autoimmune neuromuscular disease. However, anti-glutamate receptor antibody limbic encephalitis (LE) with thymoma is relatively rare.

    Case Presentation: A 68-year-old woman was admitted with progressive memory impairment and personality change. Read More

    Sensory neuronopathy associated with cholangiocarcinoma diagnosed 6 years after symptom onset.
    BMJ Case Rep 2017 Dec 20;2017. Epub 2017 Dec 20.
    MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.
    A pure sensory neuronopathy (also referred to as a sensory ganglionopathy) is one of a handful of classical neurological paraneoplastic syndromes. Current guidelines recommend that in cases of sensory neuronopathy, a search for an underlying malignancy be pursued for up to 4 years. We report the case of a 52-year-old woman with a sensory neuronopathy who was eventually diagnosed with a cholangiocarcinoma 6 years after the onset of her disease. Read More

    Autoimmune Encephalitis in Critical Care: Optimizing Immunosuppression.
    Semin Respir Crit Care Med 2017 Dec 20;38(6):807-820. Epub 2017 Dec 20.
    Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Autoimmune diseases affecting the nervous systems are a common cause of admission to the intensive care unit (ICU). Although there exist several well-described clinical syndromes, patients more commonly present with progressive neurologic dysfunction and laboratory and radiographic evidence of central nervous system (CNS) inflammation. In the critical care setting, the urgency to intervene to prevent permanent damage to the nervous system and secondary injury from the systemic manifestations of these syndromes often conflicts with diagnostic uncertainty. Read More

    Successful long-term treatment of paraneoplastic optic neuropathy with mycophenolate mofetil, prednisone, and plasmapheresis.
    Am J Ophthalmol Case Rep 2017 Dec 14;8:31-34. Epub 2017 Sep 14.
    Vanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, Nashville, TN, USA.
    Purpose: To report long-term follow-up of a case of paraneoplastic optic neuropathy (PON) successfully treated with combination therapy.

    Observations: We present a confirmed case of PON from cutaneous melanoma with nearly six years of meticulous follow-up in which vision was preserved and disease remission was successfully induced with combination mycophenolate mofetil, prednisone, and plasmapheresis therapy.

    Conclusions And Importance: Treatment of PON and long-term follow-up are not well described in the literature. Read More

    Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy.
    Am J Ophthalmol Case Rep 2017 Dec 1;8:11-13. Epub 2017 Sep 1.
    Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA.
    Purpose: To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy.

    Observations: An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Read More

    Hypertensive retinopathy as the initial presentation of neuroblastoma.
    Am J Ophthalmol Case Rep 2017 Sep 23;7:123-125. Epub 2017 Jun 23.
    Northwell Health Department of Ophthalmology, Great Neck, NY, United States.
    Purpose: To describe a case of a patient who presented with hypertensive retinopathy and was found to have neuroblastoma.

    Observations: Neuroblastoma has three main ocular presentations. As a primary disease, it can present with a paraneoplastic syndrome in the form of opsoclonus, or it can present as a Horner's syndrome from its effect on the cervical sympathetic ganglia. Read More

    Bullous Pemphigoid Masquerading as Erythema Annulare Centrifugum.
    Acta Dermatovenerol Croat 2017 Oct;25(3):255-256
    Sheng-Yiao Lin, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan;
    Dear Editor, Bullous pemphigoid (BP), a relatively common autoimmune blistering disease in the elderly, is characterized by large, tense bullae on urticarial, erythematous, or normal skin. However, atypical BP with polymorphic clinical presentations is rarely encountered, leading to misdiagnosis and delayed treatments (1). BP with lesions resembling erythema gyratum repens or figurate erythema has been regarded as a paraneoplastic phenomenon (1). Read More

    Occurrence of Dermatomyositis Immediately after Mastectomy Subsequent to Severe Chemotherapeutic Drug Eruption.
    Intern Med 2017 15;56(24):3379-3383. Epub 2017 Dec 15.
    Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
    We herein report a patient with breast cancer who developed dermatomyositis (DM) immediately after mastectomy. She had a history of severe drug eruption during neoadjuvant chemotherapy six months previously. Within a month after the operation, myalgia and rash, including Gottron's papules, developed, and skeletal-muscle enzymes elevated, so she was diagnosed with probable DM according to the Bohan and Peter criteria. Read More

    Graft-versus-host disease-like erythroderma: a sign of recurrent thymoma: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8877
    aDepartment of Oncology, The First Affiliated Hospital of Jinan UniversitybDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan UniversitycDepartment of Central Laboratory, The First Affiliated Hospital of Jinan UniversitydDepartment of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
    Rationale: Thymomas are associated with numerous autoimmune disorders, such as myasthenia gravis (MG), pure red cell aplasia (PRCA), and systemic lupus erythematosus (SLE). However, graft-versus-host disease (GVHD)-like erythroderma is a relatively uncommon paraneoplastic disorder associated with thymomas and signifies a poor prognosis.

    Patient Concerns: A 35-year-old woman with medical history significant for stage IVa type AB thymoma presented with patchy erythema over face, trunk, and extremities that failed to respond to topical steroids. Read More

    Pediatric Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A Review with Pooled Analysis and Critical Care Emphasis.
    Front Pediatr 2017 24;5:250. Epub 2017 Nov 24.
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States.
    Purpose: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is being recognized with increasing frequency among children. Given the paucity of evidence to guide the critical care management of these complex patients, we provide a comprehensive review of the literature with pooled analysis of published case reports and case series.

    Methods: We performed a comprehensive literature search using PubMed, Scopus, EMBASE, and Web of Science for relevant published studies. Read More

    Clinical Relapse of Anti-AMPA Receptor Encephalitis Associated with Recurrence of Thymoma.
    Intern Med 2017 Dec 8. Epub 2017 Dec 8.
    Department of Psychiatry, Osaka General Medical Center, Japan.
    We report a rare case of anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis presenting clinical relapse in association with recurrence of thymoma. Anti-AMPAR encephalitis is an autoimmune-mediated neurological disease, frequently accompanied by the presence of neoplasms, thus comprising the spectrum of paraneoplastic syndrome. A patient had been in remission for 34 months showed clinical relapse 3 months after the detection of recurrent thymoma. Read More

    Coincidence of celiac disease with nongastrointestinal tumors in children.
    Pediatr Hematol Oncol 2017 Dec 8:1-5. Epub 2017 Dec 8.
    c Clinical Research Development Unit, Amir-Al-Momenin Hospital , Zabol University of medical sciences , Zabol , Iran.
    The association of celiac disease (CD) with cancers of gastrointestinal origin has been noted. However, coincidence of CD with nongastrointestinal neoplasms is an unusual event. Here we present five children with concurrent CD and nongastrointestinal neoplasms. Read More

    Acute Encephalitis in an Adult with Diffuse Large B-Cell Lymphoma with Secondary Involvement of the Central Nervous System: Infectious or Non-Infectious Etiology?
    J Clin Med 2017 Dec 7;6(12). Epub 2017 Dec 7.
    Infectious Disease Division, NYU-Winthrop University Hospital, Mineola, NY 11501, USA.
    Both infectious and non-infectious etiologies of acute encephalitis have been described, as well as their specific presentations, diagnostic tests, and therapies. Classic findings of acute encephalitis include altered mental status, fever, and new lesions on neuroimaging or electroencephalogram (EEG). We report an interesting case of a 61-year-old male with a history of diffuse large B-cell lymphoma with secondary involvement of the central nervous system (SCNS-DLBCL). Read More

    Case of thymoma-associated cutaneous graft-versus-host disease-like disease successfully improved by narrowband ultraviolet B phototherapy.
    J Dermatol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
    Thymoma-associated graft-versus-host disease (GVHD)-like disease is a rare paraneoplastic disease seen in patients with thymoma. Here, we describe the first case of thymoma-associated GVHD-like disease localized to the skin that was successfully improved by a combination of systemic corticosteroids and whole-body narrowband ultraviolet (UV)-B phototherapy. The patient had developed toxic epidermal necrolysis-like erosive skin lesions over the whole body. Read More

    Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity.
    Case Rep Neurol Med 2017 25;2017:2580620. Epub 2017 Oct 25.
    Department of Internal Medicine, Orlando VA Medical Center, 13800 Veterans Way, Orlando, FL 32827, USA.
    Background: Stiff person syndrome (SPS) is a rare neurologic disorder characterized by muscle rigidity. It is a disorder of reduced GABA activity leading to increased muscle tone and often painful spasms. It generally presents in the axial musculature but rarely can involve only one limb, typically a lower extremity. Read More

    Paraneoplastic Pemphigus with Underlying Retroperitoneal Inflammatory Myofibroblastic Tumor: A Case Report and Review of the Literature.
    Indian Dermatol Online J 2017 Nov-Dec;8(6):478-481
    Department of Pharmacology, Islamic Azad University, Science and Research Branch, Tehran, Iran.
    Inflammatory myofibroblastic tumor (IMT) is a peculiar low-grade neoplasm of spindle cell fibroblasts and myofibroblasts in an inflammatory background. The lung is the most common site of involvement. Here, we report a case of paraneoplastic pemphigus (PNP)-associated with an extensive retroperitoneal IMT. Read More

    Paraneoplastic Disorders.
    Continuum (Minneap Minn) 2017 12;23(6, Neuro-oncology):1653-1679
    Purpose Of Review: Paraneoplastic neurologic syndromes target specific areas of the nervous system with pathogenic autoantibodies or T-cell responses. Each syndrome conveys a risk of particular tumors. Expanded paraneoplastic antibody testing has led to improved diagnosis but created challenges involving appropriate interpretation of test results. Read More

    Paraneoplastic cerebellar syndromes associated with antibodies against Purkinje cells.
    Int J Neurosci 2017 Dec 18:1-8. Epub 2017 Dec 18.
    a Clinical Neuroimmunology and Neurochemistry, Department of Neurology , Hannover Medical School , Hannover , Germany.
    The paraneoplastic cerebellar syndrome presents as severe neuroimmunological disease associated with malignancies. Antibodies against antigens expressed by tumor cells cross-react with proteins of cerebellar Purkinje cells leading to neuroinflammation and neuronal loss. These antineuronal antibodies are preferentially investigated by serological analyses while examination of the cerebrospinal fluid is only performed infrequently. Read More

    Characteristics of cerebellar glioblastomas in adults.
    J Neurooncol 2017 Dec 1. Epub 2017 Dec 1.
    Service de Neurochirurgie D, Groupe Hospitalier Est, Hospices Civils de Lyon, 59 Bvd Pinel, 69677, Bron Cedex, France.
    Adult cerebellar glioblastomas (cGBM) are rare and their characteristics remain to be fully described. We analyzed the characteristics of 17 adult patients with cGBM and compared them to a series of 103 patients presenting a supra-tentorial glioblastoma (stGBM). The mean age at GBMc diagnosis was 53. Read More

    Paraneoplastic Pemphigus: Insight into the Autoimmune Pathogenesis, Clinical Features and Therapy.
    Int J Mol Sci 2017 Nov 26;18(12). Epub 2017 Nov 26.
    Dipartimento di Medicina Interna e Specialità Mediche, Dermatologia, Sapienza Università di Roma, Piazzale Aldo Moro, 5, 00185 Roma, Italy.
    Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients. The pathogenesis of paraneoplastic pemphigus is not yet completely understood, although some immunological aspects have been recently clarified. Read More

    [Metabolic disorders as paraneoplastic syndromes].
    Internist (Berl) 2017 Nov 27. Epub 2017 Nov 27.
    Klinik für Innere Medizin I, Martin-Luther-Universität Halle/Wittenberg, Ernst-Grube-Str. 40, 06114, Halle (Saale), Deutschland.
    Paraneoplastic syndromes are characterized by the tumor-induced release of peptide hormones and/or the initiation of immune phenomena, which elicit clinical changes and alterations in laboratory parameters independent of the tumor size and spread. In addition to neurological, endocrinal and rheumatological phenotypes, metabolic alterations play a special role in the clinical routine as they commonly present with acute symptoms in an emergency situation and necessitate immediate diagnosis and prompt initiation of treatment. Metabolic alterations within the framework of malignant diseases should be treated in a multidisciplinary team and it is often necessary to perform monitoring and treatment in an intensive care unit. Read More

    Identification of multiple cancer-associated myositis-specific autoantibodies in idiopathic inflammatory myopathies: a large longitudinal cohort study.
    Arthritis Res Ther 2017 Nov 25;19(1):259. Epub 2017 Nov 25.
    Department of Rheumatology, Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, 2 Yinhua Road, Chaoyang District, Beijing, 100029, China.
    Background: Cancer is a significant complication contributing to increased mortality in idiopathic inflammatory myopathies (IIMs), and the association between IIMs and cancer has been extensively reported. Myositis-specific autoantibodies (MSAs) can help to stratify patients into more homogeneous groups and may be used as a biomarker for cancer-associated myositis. In this study, we aimed to systematically define the cancer-associated MSAs in IIMs. Read More

    Treatment of Cerebellar Ataxia in the Context of Systemic Diseases.
    Curr Treat Options Neurol 2017 Nov 25;19(12):47. Epub 2017 Nov 25.
    Institute of Clinical Neurosciences, University of Bristol, Southmead Hospital, Bristol, BS10 5NB, UK.
    Purpose of review The purpose of this review is to assess the evidence behind treatment regimens for cerebellar ataxias occurring in the context of systemic disease. We will address systemic conditions which are associated with specific involvement of the cerebellum (rather than widespread nervous system involvement) and those conditions for which some degree of evidence of treatment response exists. Recent findings We have divided systemic disorders affecting the cerebellum into systemic immunological disorders, endocrine and metabolic disorders and paraneoplastic. Read More

    Twist on a classic: vitamin D and hypercalcaemia of malignancy.
    BMJ Case Rep 2017 Nov 23;2017. Epub 2017 Nov 23.
    Department of Medicine, Cornell University Joan and Sanford I Weill Medical College, New York, USA.
    Malignancy is the most common cause of hypercalcaemia in the inpatient setting. Most cases are caused by tumour production of parathyroid hormone-related protein and osseous metastases. In less than 1% of cases, hypercalcaemia is driven by increased production of 1,25-dihydroxyvitamin D (1,25(OH)2D), a mechanism most commonly seen in haematological malignancies. Read More

    Digital clubbing as a first clinical presentation of pulmonary metastases in cutaneous melanoma.
    Postgrad Med 2017 Nov 27:1-2. Epub 2017 Nov 27.
    a Department of Medical Oncology, Institute of Oncology , University of Istanbul , Istanbul , Turkey.
    Digital clubbing is a paraneoplastic phenomenon usually associated with non-small cell lung cancer. We report the development of clubbing in a 49-year old man diagnosed with cutaneous melanoma which had metastasized to the lungs. We also reviewed the literature to understand the association between metastatic melanoma and clubbing. Read More

    Inflammatory Breast Cancer and Warm Antibody Autoimmune Hemolytic Anemia: A Rare Paraneoplastic Syndrome.
    J Investig Med High Impact Case Rep 2017 Oct-Dec;5(4):2324709617740905. Epub 2017 Nov 13.
    East Tennessee State University, Johnson City, TN, USA.
    Autoimmune hemolytic anemia (AIHA) is a disease process that involves the destruction of red blood cells mediated by the humoral immune system. It can be characterized as a cold agglutinin syndrome, paroxysmal cold hemoglobinuria, and warm, mixed type, and drug-induced AIHA. Although a well-established relationship exists between the presence of AIHA and lymphoproliferative malignancy, AIHA rarely presents in association with solid malignancies. Read More

    Diagnosis of Castleman Disease.
    Hematol Oncol Clin North Am 2018 Feb;32(1):53-64
    Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, M230 Boston, MA 02215, USA; VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA, USA. Electronic address:
    Castleman disease (CD) is a rare and heterogenous group of disorders sharing in common an abnormal lymph node pathology. CD comprises distinct subtypes with different prognoses. Unicentric CD and multicentric CD are featured by specific systemic manifestations and may be associated with Kaposi sarcoma, non-Hodgkin and Hodgkin lymphoma, and POEMS syndrome. Read More

    The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease.
    Hematol Oncol Clin North Am 2018 Feb;32(1):153-163
    Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905. Electronic address:
    Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes (POEMS) syndrome is a rare paraneoplastic disorder. The polyneuropathy can be the presenting symptom and is typically a painful, motor-predominant polyradiculoneuropathy often mimicking chronic inflammatory demyelinating polyradiculoneuropathy. The presence of a lambda monoclonal protein, elevated vascular endothelial growth factor, systemic features, and treatment resistance are clues to the diagnosis. Read More

    POEMS Syndrome: Diagnosis and Investigative Work-up.
    Hematol Oncol Clin North Am 2018 Feb;32(1):119-139
    Division of Hematology, Department of Medicine, Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
    POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of a combination of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis, and Castleman disease is the first step in managing the disease. Increased blood levels of vascular endothelial growth factor are usually confirmatory. Read More

    Seeing is believing: A review of apheresis therapy in the treatment of ophthalmologic disease.
    J Clin Apher 2017 Nov 18. Epub 2017 Nov 18.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
    Apheresis procedures have a role in treatment of disparate diseases involving many different organ systems. Often the disease processes where apheresis plays a role in treatment are considered "orphan diseases"-relatively rare disease processes that lack specific pharmaceutical agents or established treatment protocols. Many of these disease processes can affect the eye with devastating results for the eyesight of these patients. Read More

    Tumour TIF1 mutations and loss of heterozygosity related to cancer-associated myositis.
    Rheumatology (Oxford) 2017 Nov 14. Epub 2017 Nov 14.
    Internal Medicine Department, Vall d'Hebron University Hospital.
    Objectives: To analyse the influence of genetic alterations and differential expression of transcription intermediary factor 1 ( TIF1 ) genes in the pathophysiology of cancer-associated myositis (CAM).

    Methods: Paired blood and tumour DNA samples from patients with anti-TIF1γ-positive CAM and from controls were analysed by whole-exome sequencing for the presence of somatic mutations and loss of heterozygosity (LOH) in their TIF1 genes. The genesis and maintenance of the autoimmune process were investigated immunohistochemically by studying TIF1γ expression in the different tissues involved in CAM (skin, muscle and tumour) based on the immunohistochemical H-score. Read More

    Paraneoplastic neuromyelitis optica spectrum disorder: A case report and review of the literature.
    J Clin Neurosci 2018 Feb 10;48:7-10. Epub 2017 Nov 10.
    Department of Neurology, Faculty of General Medicine, University of Szeged, Szeged, Hungary; MTA-SZTE Neuroscience Research Group, Szeged, Hungary. Electronic address:
    Neuromyelitis optica spectrum disorders (NMOSD) are demyelinating, autoimmune diseases affecting the central nervous system. Typically, recurrent optic neuritis and longitudinal extensive transverse myelitis dominates the clinical picture. In most cases NMOSD are associated with autoantibodies targeting the water channel aquaporin-4 (AQP-4). Read More

    The unrecognized role of tumor suppressor genes in atrial fibrillation.
    Gene 2018 Feb 7;642:26-31. Epub 2017 Nov 7.
    Institute of Cardiovascular Research, The Key Laboratory of Medical Electrophysiology, Ministry of Education of China, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, China.
    Epidemiogical evidence has shown that the incidence of atrial fibrillation in tumor patients is higher than non-tumor patients and general population. The potential risk factors predisposing tumor patients to atrial fibrillation include advanced age, comorbidities, direct anatomic local occupying effect of tumors in the heart or adjacent organs, paraneoplastic manifestations of some tumors, tumor-induced dys-regulation of metabolism, radio-, bio- and chemo-therapeutics, disturbance of autonomous nerve system because of physical pain and psychological sufferings, chronic inflammation typical of most tumors, and surgical interventions among others. However, whether tumor suppressor genes commonly mutated or dys-regulated in tumor play any roles in the pathogenesis of atrial fibrillation remain largely unexplored. Read More

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