6,474 results match your criteria Paraneoplastic Diseases


Isolated recurrent myelitis in a persistent MOG positive patient.

Mult Scler Relat Disord 2019 Feb 13;30:163-164. Epub 2019 Feb 13.

Department of Neurology, Tel-Aviv Sourasky Medical Center, Weizman 6 Street, Tel-Aviv, 6423906, Israel; Autoimmune Neurology Laboratory, Tel Aviv Sourasky Medical Center, Weizman 6 Street, Tel-Aviv, 6423906, Israel; Autoimmune encephalitis and paraneoplastic syndromes clinic, Tel-Aviv Sourasky Medical Center, Weizman 6 Street, Tel-Aviv, 6423906, Israel.

MOG-Ab positive CNS demyelination typically involves the optic nerve and spinal cord. Recurrent episodes of myelitis without optic neuritis are very rare and according to current literature review represent about 3-5% of positive MOG-Ab cases. We report a 30-year-old woman with positive serum MOG-Ab suffering two discrete episodes of transverse myelitis without ophthalmic involvement. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.016DOI Listing
February 2019

Tumor-induced osteomalacia.

Osteoporos Sarcopenia 2018 Dec 12;4(4):119-127. Epub 2018 Dec 12.

Department of Endocrinology, Key Laboratory of Endocrinology, The National Commission of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic syndrome characterized by hypophosphatemia resulting from decreased tubular phosphate reabsorption, with a low or inappropriately normal level of active vitamin D. The culprit tumors of TIO could produce fibroblast growth factor 23 which plays a role in regulating renal Pi handling and 25-hydroxyvitamin D 1α-hydroxylase activity. Chronic hypophosphatemia could eventually lead to inadequate bone mineralization, presenting as osteomalacia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24055255183009
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http://dx.doi.org/10.1016/j.afos.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372818PMC
December 2018
1 Read

Paraneoplastic Eosinophilic Dermatosis in a Case of Chronic Lymphocytic Leukemia.

Indian Dermatol Online J 2019 Jan-Feb;10(1):61-63

Department of Skin and VD, SBH Govt. Medical College, Dhule, Department of Skin and VD, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

Eosinophilic dermatosis of hematologic malignancy is a rare paraneoplastic manifestation particularly associated with chronic lymphocytic leukemia (CLL).Clinically, it presents as a peculiar polymorphic pruritic eruption with characteristic histological findings of superficial and deep dense perivascular infiltrate of lymphocytes and eosinophils without any vasculitis. Although it has been reported intermittently with different names, there is paucity of reports of this condition in Indian literature. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_121_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362748PMC
February 2019

Increased Galectin-1 Expression in Thymic Epithelial Tumors.

Clin Lung Cancer 2018 Dec 21. Epub 2018 Dec 21.

Department of Radiation Oncology, Stanford University School of Medicine Stanford Cancer Institute, Stanford, CA.

Introduction: Thymic epithelial tumors (TET) are rare malignancies with a paucity of data on biology and therapeutics. Galectin-1 is a member of the β-galactoside binding protein family and has been shown to mediate tumor growth via modulation of immune cell function. This study examined galectin-1 expression in TET. Read More

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http://dx.doi.org/10.1016/j.cllc.2018.12.005DOI Listing
December 2018

Gynecological neoplasms associated with paraneoplastic hypercalcemia.

Authors:
D Lim E Oliva

Semin Diagn Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Approximately 5% of gynecological malignancies are associated with paraneoplastic hypercalcemia. Awareness of its association with certain tumor types allows for earlier disease detection and facilitates monitoring of treatment response and disease recurrence. We review the salient clinicopathological features, differential diagnosis and management issues in some of these gynecological tumors, namely: small cell carcinoma, hypercalcemic type; ovarian clear cell carcinoma, dysgerminoma and juvenile granulosa cell tumors. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.003DOI Listing
February 2019

Aquaporin-4 antibody positive short transverse myelitis associated with breast cancer.

Mult Scler Relat Disord 2019 Feb 8;30:119-122. Epub 2019 Feb 8.

Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS). A typical finding on spinal magnetic resonance imaging (MRI) of NMOSD is longitudinally extensive transverse myelitis (LETM). However, patients with NMOSD presenting with short-segment transverse myelitis (STM) during myelitis attacks associated with breast cancer are uncommon. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.011DOI Listing
February 2019

Severe Refractory Paraneoplastic Mucous Membrane Pemphigoid Successfully Treated With Rituximab.

Front Med (Lausanne) 2019 29;6. Epub 2019 Jan 29.

Department of Dermatology, Venerology and Allergology, Charité- Universitätsmedizin Berlin, Berlin, Germany.

Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease of the mucous membranes, which can cause irreversible scarring and is discussed to be associated with cancer, if laminin-332-autoantibodies are present. MMP with severe ocular and laryngeal involvement is difficult to treat and can be treatment-refractory to conventional immunosuppressant therapy. A 67-year-old man with a history of prostate cancer presented to our clinic with sore throat, intraoral bullae, odynophagia, dysphonia, exertional dyspnea, and erosions of the glans penis. Read More

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http://dx.doi.org/10.3389/fmed.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362419PMC
January 2019
3 Reads

Dronabinol for the Treatment of Paraneoplastic Night Sweats in Cancer Patients: A Report of Five Cases.

J Palliat Med 2019 Feb 13. Epub 2019 Feb 13.

4 Palliative Medicine, Stanford University School of Medicine, Stanford, California.

Background: Night sweats significantly impact the quality of life for cancer patients and are often resistant to treatment. Cannabinoids have been shown to modulate cytokine activity and produce hypothermia in animal models, suggesting that they may be a promising candidate for palliation of night sweats in patients with oncologic disease.

Objective: Assess efficacy of the oral cannabinoid, dronabinol, for palliation of night sweats in cancer patients. Read More

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http://dx.doi.org/10.1089/jpm.2018.0551DOI Listing
February 2019

Acute Anaemia: A Challenging Diagnosis.

Eur J Case Rep Intern Med 2018 27;5(9):000956. Epub 2018 Sep 27.

Internal Medicine Department, Hospital São Francisco Xavier, Lisbon, Portugal.

Acute anaemia is characterized by a reduction in the number of red blood cells, haemoglobin levels or haematocrit. By far the most common aetiology is haemorrhage, but in its absence other less frequent causes should be considered. The authors present the case of a 42-year-old man with a diagnosis of glucose-6-phosphate deficiency and progressing gastric signet ring cell carcinoma, who was admitted to the internal medicine department for symptomatic back pain control. Read More

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http://dx.doi.org/10.12890/2018_000956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346818PMC
September 2018
1 Read

Remitting Seronegative Symmetrical Synovitis with Pitting Oedema as the First Manifestation of an Adenocarcinoma of the Caecum.

Eur J Case Rep Intern Med 2018 27;5(12):000976. Epub 2018 Dec 27.

Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) is a rare syndrome that affects the elderly. Although the aetiology is not fully understood, it has been related to multiple diseases including cancer. We present the case of an 80-year-old man with a full spectrum of signs and symptoms compatible with RS3PE: sudden onset of bilateral polyarthralgia of the metacarpophalangeal and proximal interphalangeal joints, oedema of the dorsum of the hands, increased inflammatory markers and seronegative rheumatoid factor. Read More

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http://dx.doi.org/10.12890/2018_000976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346972PMC
December 2018

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
1 Read

Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate.

Oncotarget 2019 Jan 1;10(1):17-29. Epub 2019 Jan 1.

Department of Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Background: Neuroendocrine carcinomas of the prostate (NEPCs) are rare tumors with poor prognosis. While platinum and etoposide-based chemotherapy regimens (PE) are commonly applied in first-line for advanced disease, evidence for second-line therapy and beyond is very limited.

Methods: Retrospective analysis of all patients with NEPCs including mixed differentiation with adenocarcinoma component and well differentiated neuroendocrine tumors (NETs, carcinoids) at two high-volume oncological centers between 12/2000 and 11/2017. Read More

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http://www.oncotarget.com/fulltext/26523
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http://dx.doi.org/10.18632/oncotarget.26523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343754PMC
January 2019
1 Read

Recent Updates on the Relationship between Cancer and Autoimmune Pancreatitis.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Autoimmune pancreatitis (AIP) is now considered a pancreatic manifestation of a newly proposed disease condition, IgG4-related disease (IgG4-RD). IgG4-RD is characterized by enhanced IgG4 antibody responses and multiple organ involvements. Recent epidemiological studies have addressed the incidence of cancer in patients with AIP and/or IgG4-RD. Read More

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http://dx.doi.org/10.2169/internalmedicine.2210-18DOI Listing
February 2019
2 Reads

Pyoderma gangrenosum: a presenting sign of myelodysplastic syndrome in undiagnosed Fanconi anemia.

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.

A 26-year-old man with a history of congenital bilateral microtia, unilateral renal agenesis, left aural atresia, and right external auditory canal occlusion admitted for right rib cartilage graft harvest and left ear re-construction. Following surgery, an ulceration with violaceous borders and a yellow fibrinous base unresponsive to broad-spectrum antibiotics developed at the harvest site. The wound was expanding and not responsive to systemic broad-spectrum antibiotics. Read More

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January 2019
2 Reads

A rapidly progressive motor neuron disease associated to a natural killer cells leukaemia.

J Neurol Sci 2019 Jan 17;398:117-118. Epub 2019 Jan 17.

IRCCS Centro Neurolesi Bonino Pulejo, Palermo, Italy.

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http://dx.doi.org/10.1016/j.jns.2019.01.029DOI Listing
January 2019

Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection.

Methods Mol Biol 2019 ;1941:225-255

Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to an underlying neoplasm. Some of these paraneoplastic encephalitides express serum antibodies, but these were not thought to be pathogenic but instead have a T-cell-mediated pathophysiology. Over the last two decades, several pathogenic antibodies against neuronal surface antigens have been described in autoimmune encephalitis, which are amenable to immunotherapy. Read More

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http://dx.doi.org/10.1007/978-1-4939-9077-1_15DOI Listing
January 2019
1 Read

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors.

Front Immunol 2018 10;9:3112. Epub 2019 Jan 10.

Medical School, Montpellier University, Montpellier, France.

Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03112
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http://dx.doi.org/10.3389/fimmu.2018.03112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335319PMC
January 2019
3 Reads

[An unusual cause of kidney disease in a diabetic patient].

Rev Med Liege 2019 Jan;74(1):15-19

Service de Néphrologie, CHU Sart Tilman, Liège, Belgique.

Diabetic nephropathy is a complication of diabetes that affects 25-40 % of diabetic patients. This complication is usually associated with other microangiopathic disorders. We describe a case of a patient suffering from type 2 diabetes with proteinuria, and no signs of retinopathy. Read More

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January 2019
2 Reads

Peliosis hepatis associated with follicular lymphoma with a rise in vascular endothelial growth factor and anaemia of inflammation.

Ecancermedicalscience 2018 20;12:882. Epub 2018 Nov 20.

Haematology Department, Virgen del Puerto Hospital, Paraje de Valcorchero s/n, 10600 Plasencia, Spain.

Follicular lymphoma does not usually present with associated paraneoplastic syndromes. We describe the case of a patient diagnosed with follicular lymphoma when investigating anaemia of chronic disease/inflammation and who, during her clinical course, developed peliosis hepatis. We have been able to confirm the similarity between the symptoms, the tumour's biology, the anaemia and peliosis, with the behaviour of endothelial growth factor, interleukins and iron metabolism disorders, which were normalised with treatment. Read More

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http://dx.doi.org/10.3332/ecancer.2018.882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345076PMC
November 2018
1 Read

Florid cutaneous papillomatosis as a marker of neoplastic recurrence.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Dermatology and Venereology, Centro Hospitalar de Sao Joao EPE, Porto, Portugal.

Florid cutaneous papillomatosis is a rare paraneoplastic dermatosis, most commonly associated with gastric adenocarcinoma. It is characterized by a sudden onset of hyperkeratotic papules, clinically indistinguishable from viral warts. We report an 80-year-old man who presented to our department with a two-month history of multiple verrucous lesions affecting the face, perioral region, and hands. Read More

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Diagnosing autoimmune encephalitis based on clinical features and autoantibody findings.

Authors:
Christian G Bien

Expert Rev Clin Immunol 2019 Jan 24. Epub 2019 Jan 24.

a Epilepsy Center Bethel, Krankenhaus Mara , Maraweg 17-21 33617 Bielefeld , Germany.

Introduction: Autoimmune encephalitides have been accepted as a reproducible and treatable new group of diseases. At present, there is concern that such diagnoses might be made too liberally. Areas covered: This article suggests how to make valid diagnoses. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1573676DOI Listing
January 2019
2 Reads

Pain and Swelling after Percutaneous Endoscopic Gastrostomy Removal: An Unexpected Evolution.

GE Port J Gastroenterol 2018 Dec 7;26(1):59-63. Epub 2018 Mar 7.

Gastroenterology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal.

Gastrostomy site metastization is considered an uncommon complication of percutaneous endoscopic gastrostomy (PEG) placement in patients with head and neck tumours, but it is important to consider this possibility when evaluating gastrostomy-related symptoms. The authors present the case of a 40-year-old male with excessive alcohol consumption and active smoking, diagnosed with a stage IV oropharyngeal squamous cell carcinoma. The patient developed a paraneoplastic demyelinating motor polyneuropathy that, associated with tumour mass effect, caused dysphagia with need for nasogastric tube feeding. Read More

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https://www.karger.com/Article/FullText/487157
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http://dx.doi.org/10.1159/000487157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341374PMC
December 2018
10 Reads

99mTc-HYNIC-TOC in the Evaluation of Recurrent Tumor-Induced Osteomalacia.

Clin Nucl Med 2019 Mar;44(3):209-213

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, China.

Purpose: Tumor-induced osteomalacia (TIO) is rare paraneoplastic disorder generally caused by small benign neoplasm. Somatostatin receptor imaging has emerged as imaging of the choice in the localization of the causative tumors in new patients with clinical diagnosis of TIO. An accurate localization of the causative tumor using somatostatin receptor imaging followed by successful surgical removal offers cure of the disease. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002458DOI Listing
March 2019
1 Read

Unilateral renal cystadenocarcinoma and nodular dermatofibrosis in a mixed-breed dog carrying a FLCN gene mutation.

Vet Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Veterinary Medicine, University of Bari, Str. Prov. per Casamassima km 3, 70010, Valenzano, Bari, Italy.

Background: Renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare inherited cancer syndrome observed predominantly in the German shepherd dog breed, known to be associated with dominant autosomal transmission of mutation H255R of the encoding folliculin gene (FLCN). The syndrome usually features bilateral, multifocal kidney tumours and skin nodules, consisting of dense collagen fibres, with previous reports showing a poor prognosis. Although historically nodular dermatofibrosis (ND) has been considered a paraneoplastic syndrome associated with renal cystadenocarcinoma; this hypothesis has been questioned. Read More

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http://dx.doi.org/10.1111/vde.12719DOI Listing
January 2019

Necrolytic Migratory Erythema: Complete Healing after Surgical Removal of Pancreatic Carcinoma.

Acta Dermatovenerol Croat 2018 Dec;26(4):329-332

Professor Marija V'lckova-Laskoska, MD, PhD, Department of Dermatology , University Hospitals and Clinics, University of Sts. Cyril and Methodius Vodnjanska 17, 1000 Skopje, Macedonia;

Necrolytic migratory erythema is considered an obligatory cutaneous paraneoplastic sign associated with glucagonoma. Glucagonoma syndrome is defined by the presence of an alpha-cell secreting tumor of the pancreas, elevated levels of glucagon, and a characteristic rash called necrolytic migratory erythema. Although necrolytic migratory erythema is a specific finding in glucagonoma syndrome, it may occur in other settings, unassociated with an alpha-cell pancreatic tumor (pseudoglucagonoma syndrome). Read More

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December 2018
2 Reads

Encephalitis with anti-NMDA receptor antibodies: paraneoplastic or non-paraneoplastic?

Neuro Endocrinol Lett 2018 Dec 22;39(5):351-354. Epub 2018 Dec 22.

Department of Neurology, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital, Hradec Kralove, Czech Republic.

We report the case of an encephalitis patient with anti-N-methyl-D-aspartate receptor (NMDAR) antibody positivity. Anti-NMDAR encephalitis is a relatively rare autoimmune disease. In our patient, the diagnosis of anti-NMDAR encephalitis was established as late as several months after the first manifestations of the condition. Read More

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December 2018
2 Reads

Microglial nodules provide the environment for pathogenic T cells in human encephalitis.

Acta Neuropathol 2019 Jan 20. Epub 2019 Jan 20.

Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria.

Microglia nodule formation is a common feature in inflammatory brain diseases mediated by T lymphocytes such as viral and paraneoplastic encephalitis, multiple sclerosis, and Rasmussen encephalitis (RE). However, its role has not been fully understood yet. We hypothesized that, in RE, microglial nodules provide an environment for the initiation of the later dominating T-cell cytotoxicity. Read More

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http://dx.doi.org/10.1007/s00401-019-01958-5DOI Listing
January 2019
3 Reads

Spinal phosphaturic mesenchymal tumors: Case report and literature review.

J Clin Neurosci 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address:

Tumor-induced osteomalacia (TIO) is regarded as a rare paraneoplastic syndrome generally caused by phosphaturic mesenchymal tumors (PMTs). As far as we know, only 18 spinal PMTs have been described in the world's English literature. The purpose of this study is to increase familiarity with its clinical features, diagnosis, and treatment of spinal PMTs. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.010DOI Listing
January 2019
1 Read

Erythema Gyratum Repens Associated with Anal Cancer.

N Engl J Med 2019 Jan;380(3):e3

University of Kansas Medical Center, Kansas City, KS

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http://www.nejm.org/doi/10.1056/NEJMicm1805833
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http://dx.doi.org/10.1056/NEJMicm1805833DOI Listing
January 2019
5 Reads

Paraneoplastic Teratoma-associated Anti-N-Methyl-D-Aspartate Receptor Encephalitis: The First Published Report from Saudi Arabia.

Cureus 2018 Oct 31;10(10):e3527. Epub 2018 Oct 31.

Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU.

Paraneoplastic teratoma-associated anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is a lately introduced disease that was first documented in 2007. In a recent systemic review in 2014, only a total of 174 cases of teratoma-associated anti-NMDA receptor encephalitis was reported. Herein, to the best of our knowledge, in Saudi Arabia, we report the first ever case of mature ovarian teratoma-associated anti-NMDA receptor encephalitis in a 21-year-old Saudi woman who presented to clinical attention with a nine-day history of neuropsychiatric symptoms preceded by a two-day flu-like illness. Read More

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http://dx.doi.org/10.7759/cureus.3527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318106PMC
October 2018

Rare case of Hashimoto's encephalitis mimicking grief reaction.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Diabetes and Endocrinology, Royal Glamorgan Hospital, Llantrisant, UK.

A 46-year-old woman was admitted with tonic-clonic seizures. She was noticed to be withdrawn and low in mood for few months. She had reduced level of consciousness with hyper-reflexia and myoclonus. Read More

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http://dx.doi.org/10.1136/bcr-2018-227190DOI Listing
January 2019
6 Reads

Genetic and transcriptional landscape of plasma cells in POEMS syndrome.

Leukemia 2019 Jan 11. Epub 2019 Jan 11.

Department of Hematology, Chiba University Hospital, Chiba, Japan.

POEMS syndrome is a rare paraneoplastic disease associated with monoclonal plasma cells; however, the pathogenic importance of plasma cells remains unclear. We performed comprehensive genetic analyses of plasma cells in 20 patients with POEMS syndrome. Whole exome sequencing was performed in 11 cases and found a total of 308 somatic mutations in 285 genes. Read More

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http://www.nature.com/articles/s41375-018-0348-x
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http://dx.doi.org/10.1038/s41375-018-0348-xDOI Listing
January 2019
2 Reads

Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO).

Bone Rep 2019 Jun 31;10:100192. Epub 2018 Dec 31.

Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan.

Tumor-induced rickets/osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumors that ectopically express fibroblast growth factor 23 (FGF23). FGF23 is a bone-derived hormone that regulates serum phosphate concentrations. Patients with TIO develop hypophosphatemic rickets/osteomalacia due to FGF23 excess and suffer from symptoms such as leg deformities, bone pain, skeletal muscle myopathy, and multiple fractures/pseudofractures. Read More

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http://dx.doi.org/10.1016/j.bonr.2018.100192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321977PMC
June 2019
3 Reads

Paraneoplastic limbic encephalitis revealing a small cell carcinoma of the lung.

Respir Med Case Rep 2019 27;26:157-160. Epub 2018 Dec 27.

Pulmonology Department, Pavilion 4, Abderrahman Mami Hospital, Tunisia.

Introduction: Paraneoplastic limbic encephalitis is a rare disease, usually associated with small cell lung cancer.

Case Report: We report in this publication the cases with different age brackets, who presented with various neurological symptoms such as repetitive seizures or anterograde amnesia. Cerebral CT-scan, cerebral MRI and anti onco-neural paraneoplastic antibodies were suggesting the diagnosis of paraneoplastic limbic encephalitis. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319301PMC
December 2018
2 Reads

Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-018-0316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320604PMC
January 2019
5 Reads

Japanese Encephalitis Virus-Induced Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature.

Neuropediatrics 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, Zunyi Medical University, First Affiliated Hospital, Zunyi, Guizhou Province, China.

Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARe) was originally described as a paraneoplastic disease with more than 50% cases involving a tumor. However, tumor incidence in anti-NMDARe in children is much lower. Herpes simplex virus-induced anti-NMDARe has been well-described; however, findings on Japanese encephalitis virus (JEV)-induced anti-NMDARe are scarce. Read More

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http://dx.doi.org/10.1055/s-0038-1675607DOI Listing
January 2019
3 Reads

A systematic review of Gamma-aminobutyric Acid Receptor Type B autoimmunity.

Neurol Neurochir Pol 2019 Jan 8. Epub 2019 Jan 8.

Mayo Clinic, Jacksonville, Florida, United States.

Objective: To review the available research to describe the clinical characteristics and neoplastic associations of patients with gamma-aminobutyric acid receptor type B (GABAB-R) autoantibodies.

Methods: Literature was reviewed on PubMed, Mendeley literature search, and the American Academy of Neurology database for articles published from June 2008 to October of 2018 using a variety of key words. These key words include: "gamma-aminobutyric acid seizures," "gamma-aminobutyric acid limbic encephalitis", "GABA(B) receptor antibodies," "autoimmune encephalitis," "autoimmune epilepsy," "GABA(B) encephalitis, " and "GABA paraneoplastic. Read More

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https://journals.viamedica.pl/neurologia_neurochirurgia_pols
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http://dx.doi.org/10.5603/PJNNS.a2018.0005DOI Listing
January 2019
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EEG analysis in anti-NMDA receptor encephalitis: Description of typical patterns.

Clin Neurophysiol 2019 Feb 29;130(2):289-296. Epub 2018 Nov 29.

Department of Neurology, University Hospital Center of Saint-Etienne, France; NeuroPain Lab, Lyon Neuroscience Research Centre, CRNL-InsermU 1028/CNRS UMR5292, University of Lyon, France. Electronic address:

Objective: To describe different electroencephalogram (EEG) patterns and epileptic features in patients with anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE), their timeline in the course of the disease, their correlation with clinical data and outcome.

Methods: We retrospectively analyzed EEG recordings between November 2007 and June 2016 in 24 consecutive patients.

Results: Three EEG patterns were described: Excessive Beta Activity range 14-20 Hz (EBA) in 71% of patients, Extreme Delta Brush (EDB) in 58% and Generalized Rhythmic Delta Activity (GRDA) in 50%. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.10.017DOI Listing
February 2019
3 Reads

THSD7A as a marker for paraneoplastic membranous nephropathy.

Int Urol Nephrol 2019 Jan 3. Epub 2019 Jan 3.

Department of Medical Image, HeBei General Hospital, Shijiazhuang, People's Republic of China.

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http://link.springer.com/10.1007/s11255-018-02068-z
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http://dx.doi.org/10.1007/s11255-018-02068-zDOI Listing
January 2019
6 Reads

Anti-Yo antibody-mediated paraneoplastic cerebellar degeneration associated with cognitive affective syndrome in a patient with breast cancer: a case report and literature review.

Authors:
M Le May S Dent

Curr Oncol 2018 Dec 1;25(6):e585-e591. Epub 2018 Dec 1.

Department of Medicine, Division of Medical Oncology, University of Ottawa, Ottawa, ON.

Breast cancer is the most common cancer in women, with 15%-25% of those tumours overexpressing the human epidermal growth factor receptor 2 (her2), which is associated with more aggressive disease. On rare occasions, patients present with a paraneoplastic syndrome months to years before their cancer diagnosis. Paraneoplastic cerebellar degeneration (pcd) is associated with fewer than 1% of cancers and is strongly associated with breast and gynecologic malignancies. Read More

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http://dx.doi.org/10.3747/co.25.4106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291278PMC
December 2018
2 Reads

Galactorrhea, mastodynia and gynecomastia as the first manifestation of lung adenocarcinoma. A case report.

Respir Med Case Rep 2019 4;26:146-149. Epub 2018 Dec 4.

Thoracic Surgery Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.

Gynecomastia with mastodynia and galactorrhea as a paraneoplastic syndrome due to lung cancer with complete response after surgical excision is rare. A 62-year-old Caucasian male presented with mastodynia, galactorrhea and right breast enlargement. Chest x-ray revealed a left upper lobe tumor. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307343PMC
December 2018
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A case report of sphenoid sinusitis causing opsoclonus myoclonus syndrome.

AME Case Rep 2018 19;2:47. Epub 2018 Nov 19.

Department of ENT, John Radcliffe Hospital, Oxford, UK.

Opsoclonus myoclonus syndrome (OMS) is a rare neurological condition causing rapid jerking involuntary eye movements and myoclonus. The combination of opsoclonus and myoclonus have led to condition being coined the "dancing eyes, dancing feet syndrome". There are a wide variety of paraneoplastic and para-infectious aetiologies for OMS and therefore a detailed workup is needed as OMS symptoms can precede the commencement of symptoms from the underlying triggering disease process. Read More

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http://dx.doi.org/10.21037/acr.2018.11.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286885PMC
November 2018

Paraneoplastic Encephalopathy in a Patient With Metastatic Lung Cancer: A Case Study.

Authors:
Scott M Rowley

J Adv Pract Oncol 2018 Mar 1;9(2):216-221. Epub 2018 Mar 1.

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

RS, a 36-year-old female, presented to the emergency department (ED) of a large academic medical center upon the advice of her primary care provider because of 3 weeks of progressive mental status changes, weakness, and decreased oral intake. According to her husband, RS was diagnosed with stage IIIA large cell lung cancer 8 months earlier and was treated with concurrent chemotherapy (carboplatin, pemetrexed, and bevacizumab) and radiation therapy that was completed 4 months prior to admission. No other specific information about her treatment or outside health records was available. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303004PMC
March 2018
19 Reads

Diagnostic tools for immune causes of encephalitis.

Clin Microbiol Infect 2018 Dec 22. Epub 2018 Dec 22.

Division of Neurology, Department of Clinical Neuroscience, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland.

Background: Autoimmune encephalitis (AE) refers to a central nervous system (CNS) antibody-mediated entity characterized by a rapid onset behavioural and cognitive decline that can be associated with movement disorders, epileptic and dysautonomic features. Interestingly, it is thought to be as common as its infectious disease counterpart and can share some clinical, radiological, and laboratory findings.

Objectives: The aim is to describe the main clinical features of AE caused by antibodies targeting cell-surface neuronal agents and the diagnostic means to identify them. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X183080
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http://dx.doi.org/10.1016/j.cmi.2018.12.012DOI Listing
December 2018
21 Reads

Peripheral primitive neuroectodermal tumor associated with paraneoplastic Cushing's syndrome: The rare case.

Ann Med Surg (Lond) 2019 Jan 29;37:21-24. Epub 2018 Nov 29.

Iran University of Medical Science, Tehran, Iran.

Introduction: Primitive neuroectodermal tumors (PNET) form a group of tumors defined by their appearance that are thought to develop from primitive (undifferentiated) nerve cells in the brain. They are rare tumors and their incidence is not well defined.

Case Presentation: An 18-month-old male presenting with typical Cushingoid appearance (moon face, central obesity, hirsutism and growth arrest) was admitted for evaluation of endocrine problems. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287080PMC
January 2019
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Paraneoplastic rheumatic disorders: a narrative review.

Reumatismo 2018 Dec 20;70(4):199-211. Epub 2018 Dec 20.

Rheumatology Unit, Azienda Ospedaliero-Universitaria di Modena.

Paraneoplastic syndromes (PS) are a heterogeneous group of diseases related to a neoplasm, indirectly dependent on it. Diagnosis and the treatment are often a challenge for clinicians, not least because the pathogenetic mechanisms are highly complex and not entirely known. Nonetheless, in most cases, PS precede the diagnosis of malignancies, thus their identification is particularly important in addressing physicians' diagnostic work-up with regard to early cancer diagnosis. Read More

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http://dx.doi.org/10.4081/reumatismo.2018.1069DOI Listing
December 2018

Hypereosinophilia: a diagnostic challenge.

Neth J Med 2018 Dec;76(10):431-436

Harbour Hospital and Institute for Tropical Diseases, Rotterdam, the Netherlands (currently working at Albert Schweitzer Hospital, Rotterdam).

Hypereosinophilia encompasses a broad differential diagnosis of atopy/allergic reactions, drug reactions, parasitic infections and paraneoplastic syndromes. Although mostly of limited clinical significance, hypereosinophilia can also be related to hematological malignancies. One has to be aware of the potential for secondary organ damage for example, in the case of hypereosinophilic syndrome. Read More

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December 2018
2 Reads

Dermatomyositis as a paraneoplastic phenomenon in oesophageal cancer.

BMJ Case Rep 2018 Dec 7;11(1). Epub 2018 Dec 7.

Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

Dermatomyositis is a multisystem disease manifesting as an idiopathic inflammatory myopathy, characterised predominantly by cutaneous and muscular abnormalities. Patients with dermatomyositis display characteristic skin changes in addition to muscle weakness. Many consider dermatomyositis a paraneoplastic syndrome, as up to 32% of patients with dermatomyositis will develop cancer. Read More

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http://dx.doi.org/10.1136/bcr-2018-227387DOI Listing
December 2018
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Revisiting the Clinical Phenomenology of "Cerebellar Tremor": Beyond the Intention Tremor.

Cerebellum 2018 Dec 18. Epub 2018 Dec 18.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Tremor is an involuntary, rhythmic, oscillatory movement of a body part. It is a central feature of a range of diseases resulting from pathological changes in the cerebellum. Interestingly, in modern times, the terms "cerebellar tremor" and "intention tremor" are often used synonymously and interchangeably. Read More

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http://link.springer.com/10.1007/s12311-018-0994-6
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http://dx.doi.org/10.1007/s12311-018-0994-6DOI Listing
December 2018
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A cross-sectional, comparative, syndromic description of oncological mixed pain in Medical Oncology units in Spain.

Support Care Cancer 2018 Dec 18. Epub 2018 Dec 18.

Department of Statistical Design and Biometrics, Medicxact SL, Alpedrete, Spain.

Objective: The reason cancer pain remains prevalent and hard to classify may be partially explained by the failure to identify neuropathic mechanisms. The objective of this research was to identify the syndromes of cancer pain that may be particularly hard to manage due to their mixed pathophysiology.

Design: A series of 384 patients who had cancer of any type, at any stage, and suffered from chronic pain (symptom onset > 3 months) were assessed during a routine return visit in Spain. Read More

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http://dx.doi.org/10.1007/s00520-018-4575-5DOI Listing
December 2018
1 Read