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    Motor neuropathies and lower motor neuron syndromes.
    Rev Neurol (Paris) 2017 Apr 20. Epub 2017 Apr 20.
    Reference Centre for Neuromuscular Diseases and ALS, University Hospital La Timone, 264 rue Saint Pierre, 13385 Marseille cedex 05, France. Electronic address:
    Motor or motor-predominant neuropathies may arise from disease processes affecting the motor axon and/or its surrounding myelin. Lower motor neuron syndrome (LMNS) arises from a disease process affecting the spinal motor neuron itself. The term LMNS is more generally used, rather than motor neuronopathy, although both entities are clinically similar. Read More

    The role of tumor board conferences in neuro-oncology: a nationwide provider survey.
    J Neurooncol 2017 Apr 18. Epub 2017 Apr 18.
    Department of Neurosurgery, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
    The tumor board or multidisciplinary cancer meeting (MCM) is the foundation of high value multidisciplinary oncology care, coordinating teams of specialists. Little is known on how these meetings are implemented in Neuro-oncology. Benefits of MCMs include coordination, direction for complicated cases, education, and a forum for communication, emerging technology, and clinical trials. Read More

    Biotherapy in Inflammatory Diseases of the CNS: Current Knowledge and Applications.
    Curr Treat Options Neurol 2017 May;19(5):19
    Département de Neurologie, CHU de Strasbourg, Strasbourg, France.
    Opinion Statement: Biotherapy represents an innovative therapeutic approach that includes immunotherapy (vaccines, apheresis, and antibodies); gene therapy; and stem cell transplants. Their development helps to cross the bridge from bench to bedside and brings new hope of a cure for severe diseases in different fields of medicine. In neurology, a growing range of applications is being developed for these medications. Read More

    Paraneoplastic limbic encephalitis in a patient with extensive disease small-cell lung cancer.
    Mol Clin Oncol 2017 Apr 10;6(4):575-578. Epub 2017 Feb 10.
    Department of Oncology, Jagiellonian University Medical College, 31-531 Krakow, Poland.
    Paraneoplastic limbic encephalitis (PLE) is a rare disorder infrequently accompanying malignancy, coexisting in ~50% of the cases with small-cell lung cancer (SCLC). The pathomechanism of PLE is considered to be immune-mediated, with production of specific anti-Hu antibodies and activation of T-cells directed against onconeural antigens present on both tumor cells and neurons. We herein report the case of a 50-year-old male patient who, prior to being diagnosed with SCLC, presented with typical symptoms of PLE (seizures, subacute cognitive dysfunction with severe memory impairment, anxiety and hallucinations). Read More

    Cancer is a propagandist.
    Stud Hist Philos Biol Biomed Sci 2017 Apr 11;63:28-31. Epub 2017 Apr 11.
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA. Electronic address:
    Communication among cells (also known as cross-talk) plays a prominent role in the current knowledge of the pathophysiology of cancer and of cancer-associated conditions such as paraneoplastic syndromes and cachexia that are responsible for much of cancer's morbidity and mortality. Yet, biomedical scientists lack an explicit unifying frame that places this exchange of molecular information at the core of their understanding of cancer as a systemic disease. Propaganda is a type of information that aims at misleading, a form of communication intended primarily to serve the messenger. Read More

    An Unfortunate Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Change (POEMS).
    Cureus 2017 Mar 8;9(3):e1086. Epub 2017 Mar 8.
    Internal Medicine, University of Central Florida College of Medicine.
    POEMS syndrome is an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes, which is a rare paraneoplastic disease of monoclonal plasma cells. A mandatory criterion to diagnose POEMS syndrome is the presence of a monoclonal plasma cell dyscrasia in which plasma cell leukemia is the most aggressive form. Early identification of the features of the POEMS syndrome is critical for patients to identify an underlying plasma cell dyscrasias and to reduce the morbidity and mortality of the disease by providing early therapy. Read More

    Is tocilizumab a potential therapeutic option for refractory unicentric Castleman disease?
    Hematol Oncol 2017 Apr 11. Epub 2017 Apr 11.
    Department of Haematology, University Hospitals of Bristol NHS Trust, Bristol, UK.
    Castleman disease is a rare lymphoproliferative disorder with 2 distinctly defined clinical forms. While multicentric Castleman disease (UCD) poses a potential therapeutic challenge, unicentric variant has historically been considered curable with surgical resection. Hence, little is known to guide management of patients with UCD, refractory to surgical resection and combination chemotherapy. Read More

    Paraneoplastic Pemphigus Associated with a Malignant Thymoma: A Case of Persistent and Refractory Oral Ulcerations Following Thymectomy.
    Ann Dermatol 2017 Apr 24;29(2):219-222. Epub 2017 Mar 24.
    Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Paraneoplastic pemphigus is a rare, life-threatening autoimmune mucocutaneous blistering disease associated with underlying neoplasia, commonly lymphoproliferative tumors. Herein we report a case of paraneoplastic pemphigus with a unique autoantibody profile associated with a malignant thymoma. A 56-year-old female patient presented with relapsing oral ulcerations accompanied by erythematous papules and patches on her extremities for 2 months. Read More

    Adaptive Immunity Is the Key to the Understanding of Autoimmune and Paraneoplastic Inflammatory Central Nervous System Disorders.
    Front Immunol 2017 23;8:336. Epub 2017 Mar 23.
    Department of Neurology, Neuroimmunology, University of Regensburg , Regensburg , Germany.
    There are common aspects and mechanisms between different types of autoimmune diseases such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSDs), and autoimmune encephalitis (AE) as well as paraneoplastic inflammatory disorders of the central nervous system. To our present knowledge, depending on the disease, T and B cells as well as antibodies contribute to various aspects of the pathogenesis. Possibly the events leading to the breaking of tolerance between the different diseases are of great similarity and so far, only partially understood. Read More

    Paraneoplastic Glomerulopathy in a Case of Collecting Duct Renal Cell Carcinoma.
    J Clin Diagn Res 2017 Feb 1;11(2):OD03-OD04. Epub 2017 Feb 1.
    Professor and Head, Department of Nephrology, Kasturba Hospital, Manipal University , Manipal, Karnataka, India .
    Paraneoplastic glomerulopathy has been described in established cases of the solid tumors of lung, gastrointestinal system, breast, etc., and rarely in patients with Renal Cell Carcinoma (RCC). Studies on secondary glomerular diseases have described a higher incidence of IgA nephropathy in patients with RCC compared to membranous glomerulopathy, which are commonly reported in malignancies of the lung and gastrointestinal tract. Read More

    Inflammatory Myopathies with Cutaneous Involvement: from Diagnosis to Therapy.
    Folia Med (Plovdiv) 2017 Mar;59(1):7-13
    Department of Dermatology and Venereology, Medical University of Sofia, 1 St Georgi Sofiiski St., 1431 Sofia.
    The group of idiopathic inflammatory myopathies (IIM) include various disorders of skeletal muscles with or without skin involvement. The most common types are dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM). Dermatomyositis subdivides into various clinical forms such as juvenile, amyopathic or paraneoplastic dermatomyositis, scleromyositis, overlap or anti-synthetase syndromes, etc. Read More

    Pure Red Cell Aplasia Associated with Good Syndrome.
    Korean J Thorac Cardiovasc Surg 2017 Apr 5;50(2):119-122. Epub 2017 Apr 5.
    Department of Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.
    Pure red cell aplasia (PRCA) and hypogammaglobulinemia are paraneoplastic syndromes that are rarer than myasthenia gravis in patients with thymoma. Good syndrome coexisting with PRCA is an extremely rare pathology. We report the case of a 50-year-old man with thymoma and PRCA associated with Good syndrome who achieved complete PRCA remission after thymectomy and postoperative immunosuppressive therapy, and provide a review of the pertinent literature. Read More

    Idiopathic SIADH in young patients: don't forget the nose.
    Acta Otorhinolaryngol Ital 2017 Feb;37(1):76-79
    Institute of Radiology, Catholic University of Sacred Heart, Rome, Italy.
    Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine sinonasal cancer associated by many authors to ectopic production of several biologically active substances. We report a case of a 31-year-old male patient who presented with idiopathic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). During diagnostic work-up, a CT scan of the head was performed and an ethmoidal ONB was detected. Read More

    Retinitis Pigmentosa and Other Dystrophies.
    Dev Ophthalmol 2017 28;58:191-201. Epub 2017 Mar 28.
    Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal degenerations characterized by progressive degeneration of rod and cone cells that affects predominantly peripheral visual fields. Macular edema may cause additional central visual acuity decrease. Cystoid macular edema (CME) is one of the few treatable causes of visual loss in RP. Read More

    CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model.
    Oncoimmunology 2017 9;6(2):e1260212. Epub 2016 Dec 9.
    INSERM UMR1043 - CNRS U5282, Centre de Physiopathologie Toulouse-Purpan, Toulouse, France; Université Toulouse III, Tolouse, France.
    Paraneoplastic neurological disorders (PNDs) are rare human autoimmune diseases that mostly affect the central nervous system (CNS). They are triggered by an efficient immune response against a neural self-antigen that is ectopically expressed in neoplastic tumors. Due to this shared antigenic expression, the immune system reacts not only to tumor cells but also to neural cells resulting in neurological damage. Read More

    Ectopic ACTH-producing large cell neuroendocrine Pancoast tumour presenting as Horner syndrome.
    BMJ Case Rep 2017 Mar 24;2017. Epub 2017 Mar 24.
    Department of Family Medicine, Apple Valley Medical Clinic, Apple Valley, Minnesota, USA.
    We present an interesting case where a patient is presented with a droopy left eyelid (as part of Horner syndrome) and Cushingoid features which were a result of a Pancoast tumour (apical lung tumour in superior pulmonary sulcus) involving the left lung. This tumour was secreting ectopic adrenocorticotropic hormone (ACTH), a paraneoplastic endocrine phenomenon, which resulted in Cushing syndrome symptomatology. Though most ectopic ACTH-producing lung cancers are either small cell or carcinoid tumours, this was in fact a large cell neuroendocrine cancer (LCNEC). Read More

    Comparison of surgical approach and extent of resection for Masaoka-Koga Stage I and II thymic tumours in Europe, North America and Asia: an International Thymic Malignancy Interest Group retrospective database analysis†.
    Eur J Cardiothorac Surg 2017 Feb 28. Epub 2017 Feb 28.
    Division of Thoracic Surgery, Swedish Cancer Institute, Seattle, WA, USA.
    Objectives: Surgeons at different institutions worldwide choose different types of operations for thymic tumours. It is not known whether these differences affect the outcomes of the patients.

    Methods: A total of 1430 patients with Masaoka-Koga pathological Stage I-II thymic tumours without myasthenia gravis or pre-treatment were identified from the International Thymic Malignancy Interest Group retrospective database. Read More

    Sweet Syndrome.
    J Cutan Med Surg 2017 Feb 1:1203475417690719. Epub 2017 Feb 1.
    1 Department of Dermatology, Hospital das Clínicas, University of São Paulo Medical School, Sao Paulo, SP, Brazil.
    Background: Sweet syndrome (SS) is an infrequent skin disease characterised by sudden onset of fever, leukocytosis, neutrophilia, and tender erythematous plaques infiltrated by neutrophils. Multiple conditions have been associated with this syndrome.

    Objectives: The aim of this study was to evaluate the clinical, epidemiological, laboratory, and histopathological findings and associations of patients with SS. Read More

    POEMS Syndrome: an Enigma.
    Curr Hematol Malig Rep 2017 Mar 15. Epub 2017 Mar 15.
    Division of Hematology, Medicine and Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
    POEMS syndrome is a paraneoplastic disorder secondary to an underlying plasma cell dyscrasia. By definition, all patients with POEMS syndrome must display polyneuropathy and monoclonal plasma cell disorder. In addition, at least one major criterion (Castleman's disease, sclerotic bone lesions, or vascular endothelial growth factor elevation) and one minor criterion (organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, thrombocytosis, or polycythemia) are required for diagnosis. Read More

    Etiological profile of noncompressive myelopathies in a tertiary care hospital of Northeast India.
    Ann Indian Acad Neurol 2017 Jan-Mar;20(1):41-50
    Department of Neurology, Gauhati Medical College and Hospital, Guwahati, Assam, India.
    Background: The discovery of antibodies against aquaporin-4 and evolving concepts of noncompressive myelopathies in the 21(st) century have made a major impact on the etiological profile of these diseases, with few cases turning out to be idiopathic.

    Objective: To find causes of noncompressive myelopathy in a tertiary care hospital of Northeast India.

    Materials And Methods: An observational study was carried out in the Neurology Department of Gauhati Medical College, Guwahati, from September 2013 to February 2016. Read More

    Autoimmune paraneoplastic syndromes associated to lung cancer: A systematic review of the literature: Part 2: Hematologic, cutaneous and vascular syndromes.
    Lung Cancer 2017 Apr 30;106:93-101. Epub 2017 Jan 30.
    Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium; Laboratoire Facultaire de Médecine Factuelle (ULB), Belgium. Electronic address:
    The development of new immune treatment in oncology and particularly for lung cancer may induce new complications, particularly activation or reactivation of auto-immune diseases. In this context, a systematic review on the auto-immune paraneoplastic syndromes associated with lung cancer appears useful. This article is the second of a series of five and deals with hematologic, cutaneous and vascular syndromes. Read More

    Autoimmune paraneoplastic syndromes associated to lung cancer: A systematic review of the literature: Part 3: Neurological paraneoplastic syndromes, involving the central nervous system.
    Lung Cancer 2017 Apr 30;106:83-92. Epub 2017 Jan 30.
    Service des Soins Intensifs et Urgences Oncologiques & Thoracic Oncology, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), Belgium; Laboratoire facultaire de Médecine factuelle (ULB), Belgium. Electronic address:
    The development of new immune treatment in oncology and particularly for lung cancer may induce new complications, particularly activation or reactivation of auto-immune diseases. In this context, a systematic review on the auto-immune paraneoplastic syndromes that can complicate lung cancer appears useful. This article is the third of a series of five and deals mainly with neurological paraneoplastic syndromes involving the central nervous system. Read More

    Autoimmune paraneoplastic syndromes associated to lung cancer: A systematic review of the literature.
    Lung Cancer 2017 Apr 30;106:102-109. Epub 2017 Jan 30.
    Service des Soins Intensifs et Urgences Oncologiques & Oncologie thoracique, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB) et, Laboratoire Facultaire de Médecine Factuelle (ULB), Belgium. Electronic address:
    The development of new immune treatment in oncology and particularly for lung cancer may induce new complications, particularly activation or reactivation of auto-immune diseases. In this context, a systematic review on the auto-immune paraneoplastic syndromes associated with lung cancer appears useful. This article is the first of a series of five and deals with the methodology applied for the review and with renal and rheumatic syndromes. Read More

    The effect of myasthenia gravis as a prognostic factor in thymoma treatment.
    North Clin Istanb 2016 25;3(3):194-200. Epub 2017 Jan 25.
    Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
    Objective: Thymoma is a standard epithelial tumor. Though it is rare, it constitutes 50% of anterior mediastinal masses. Variety of immunological diseases may accompany thymoma; however, myasthenia gravis (MG) is the most frequently associated paraneoplastic syndrome. Read More

    Acrokeratosis paraneoplastica (Bazex syndrome) - a systematic review on risk factors, diagnosis, prognosis and management.
    J Eur Acad Dermatol Venereol 2017 Mar 8. Epub 2017 Mar 8.
    Klinik für Hautkrankheiten, Universitätsklinikum, Jena, Deutschland.
    Acrokeratosis paraneoplastica Bazex (Bazex syndrome) is a rare paraneoplastic skin disease defined by erythematous, violaceous, scaly plaques on the hands and feet and on other acral locations such as nose and ears. Bazex syndrome is linked to a variety of underlying malignancies. Usually the skin lesions develop prior to the diagnosis of an internal malignant neoplasm with spontaneous remission after tumour removal. Read More

    Anti-N-methyl-D-aspartate receptor encephalitis associated with hepatic neuroendocrine carcinoma: A case report.
    J Clin Neurosci 2017 Mar 2. Epub 2017 Mar 2.
    National Neuroscience Institute, Singapore General Hospital Campus, 20 College Road, Academia 169856, Singapore. Electronic address:
    Anti-N-methyl-D-aspartate receptor (Anti-NMDAR) encephalitis can present with and without tumor. Tumor associations are less common in older patients. We report a 65-year-old gentleman who presented with one week history of cough, chills, rigor and altered behavior, followed by florid visual and auditory hallucinations. Read More

    Diagnostic Value of Positron Emission Tomography Combined with Computed Tomography for Evaluating Critically Ill Neurological Patients.
    Front Neurol 2017 14;8:33. Epub 2017 Feb 14.
    Department of Intensive Care, University Medical Center Hamburg-Eppendorf , Hamburg , Germany.
    Purpose: (18)F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is a promising new tool for the identification of inflammatory, infectious, and neoplastic foci. The aim of our work was to evaluate the diagnostic value of FDG-PET/CT in patients treated on a neurological/neurosurgical ICU or stroke unit.

    Methods: We performed a single-center, 10-year, retrospective evaluation of the value of FDG-PET/CT in critically ill adult patients with severe neurological disease. Read More

    [Review of the psychiatric aspects of anti-NMDA (N-methyl-D-aspartic acid) receptor encephalitis, case report, and our plans for a future study].
    Neuropsychopharmacol Hung 2016 Dec;18(4):199-208
    Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary.
    Anti-NMDAR (N-methyl-D-aspartic acid receptor) encephalitis, first described in 2007, is a rare, autoimmune limbic encephalitis. In half of the cases anti-NMDAR antibodies are paraneoplastic manifestations of an underlying tumor (mostly ovarian teratoma). In the early stage of the disease psychiatric symptoms are prominent, therefore 60-70% of the patients are first treated in a psychiatric department. Read More

    Thymoma-associated multi-organ autoimmunity: A case of graft-versus-host disease-like erythroderma complicated by Good syndrome successfully treated by thymectomy.
    J Dermatol 2017 Mar 3. Epub 2017 Mar 3.
    Department of Dermatology, Hiratsuka City Hospital, Kanagawa, Japan.
    Thymoma-associated multi-organ autoimmunity disease (TAMA) is a rare paraneoplastic disorder, clinicopathologically similar to graft-versus-host disease (GVHD). Many reported cases follow a difficult course; half of them die from serious infectious diseases subsequent to immunosuppression induced by chemotherapy for unresectable thymoma, or intensive therapies including systemic steroids for complicating autoimmune diseases and GVHD-like symptoms. We report a patient whose skin symptoms were improved subsequently to total thymectomy. Read More

    Netrin-1 receptor antibodies in thymoma-associated neuromyotonia with myasthenia gravis.
    Neurology 2017 Mar 1;88(13):1235-1242. Epub 2017 Mar 1.
    From the Laboratorio de Neurología (E.T.-V., T.S., J.J.V., L.B.), Instituto de Investigación Sanitaria La Fe, Hospital Universitario y Politécnico La Fe, CIBERER, Valencia; Servicio de Anatomía Patológica (N.M.), Servicio de Neurofisiología Clínica (M.J.C.), and Servicio de Neurología (T.S., J.J.V., L.B.), Hospital Universitario y Politécnico La Fe, Valencia; Laboratorio de Neurobiología Comparada (A.C.-S., V.H.-P., J.M.G.-V.), Instituto Cavanilles, Universidad de Valencia, CIBERNED; Servicio de Neurología (G.M.), Hospital Central de Asturias, Oviedo, Spain; French Reference Center on Paraneoplastic Neurological Syndrome (B.J., J.H.), Hospices Civils de Lyon, Hôpital Neurologique, Bron, and Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, Université de Lyon-Université Claude Bernard Lyon 1, France; Laboratori de Neurologia (J.D., F.G.), Institut d´Investigacions Biomèdiques August Pi I Sunyer, CIBERER, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, and Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
    Objective: To identify cell-surface antibodies in patients with neuromyotonia and to describe the main clinical implications.

    Methods: Sera of 3 patients with thymoma-associated neuromyotonia and myasthenia gravis were used to immunoprecipitate and characterize neuronal cell-surface antigens using reported techniques. The clinical significance of antibodies against precipitated proteins was assessed with sera of 98 patients (neuromyotonia 46, myasthenia gravis 52, thymoma 42; 33 of them with overlapping syndromes) and 219 controls (other neurologic diseases, cancer, and healthy volunteers). Read More

    Long-term survival in paraneoplastic Lambert-Eaton myasthenic syndrome.
    Neurology 2017 Apr 1;88(14):1334-1339. Epub 2017 Mar 1.
    From the Department of Neurology (P.M.), Nottingham University Hospitals NHS Trust, Queen's Medical Centre; Division of Clinical Neuroscience (P.G.), University of Nottingham, Queen's Medical Centre; Department of Statistics (M.J.G.), University of Nottingham, Nottingham City Hospital; and Nuffield Department of Clinical Neurosciences (B.L.), University of Oxford, John Radcliffe Hospital, Oxford, UK.
    Objective: To establish whether improved tumor survival in patients with Lambert-Eaton myasthenic syndrome (LEMS) and small-cell lung cancer (SCLC) was due to known prognostic risk factors or an effect of LEMS independently, perhaps as a result of circulating factors.

    Methods: We undertook a prospective observational cohort study of patients with LEMS attending Nottingham University Hospitals, UK, or via the British Neurological Surveillance Unit. In parallel, patients with a new diagnosis of biopsy-proven SCLC were enrolled, examined for neurologic illness, and followed up until death or study end. Read More

    Yellow nail syndrome: a review.
    Orphanet J Rare Dis 2017 Feb 27;12(1):42. Epub 2017 Feb 27.
    Nail Disease Centre, 42, rue des Serbes, 06400, Cannes, France.
    Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. Read More

    (18)F-FDG PET-CT imaging versus bone marrow biopsy in pediatric Hodgkin's lymphoma: a quantitative assessment of marrow uptake and novel insights into clinical implications of marrow involvement.
    Eur J Nucl Med Mol Imaging 2017 Feb 22. Epub 2017 Feb 22.
    Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, 7-A, Block R-3, Johar Town, Lahore, Pakistan, 54000.
    Objective: To evaluate whether positron emission tomography/computed tomography using fluorine-18 fluoro-deoxyglucose ((18)F-FDG PET-CT) predicts bone marrow involvement (BMI) in pediatric Hodgkin's lymphoma (pHL) with sufficient accuracy to supplant routine staging bone marrow biopsy (BMB), and to assess the clinical importance of marrow disease by comparing the prognosis of stage IV HL with BMI versus that without BMI.

    Methods: Data were retrospectively analyzed for all cases of pHL between July 2010 and June 2015 referred for staging (18)F-FDG PET-CT scan and BMB. The reference standard was BMB. Read More

    Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: A case report.
    Medicine (Baltimore) 2017 Feb;96(8):e6184
    Department of Hematology, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China.
    Rationale: Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with neoplasms. The treatment approach principally includes suppressing the immunity, but its therapeutic effect is not satisfying.

    Patient Concerns: We report a case of paraneoplastic pemphigus linked to chronic lymphocytic leukemia in a 63-year-old man. Read More

    Syndrome of inappropriate antidiuretic hormone secretion following irinotecan-cisplatin administration as a treatment for recurrent ovarian clear cell carcinoma.
    Obstet Gynecol Sci 2017 Jan 19;60(1):115-117. Epub 2017 Jan 19.
    Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
    Syndrome of inappropriate antidiuretic hormone secretion (SIADH) has various causes including central nervous system disorders, pulmonary and endocrine diseases, paraneoplastic syndromes, and use of certain drugs. SIADH induced by chemotherapy with irinotecan-cisplatin is not a common complication. Here, we review a case of SIADH after treatment with irinotecan-cisplatin. Read More

    Metabolic Bone Disease in the Context of Metastatic Neuroendocrine Tumor: Differentiation from Skeletal Metastasis, the Molecular PET-CT Imaging Features, and Exploring the Possible Etiopathologies Including Parathyroid Adenoma (MEN1) and Paraneoplastic Humoral Hypercalcemia of Malignancy Due to PTHrP Hypersecretion.
    World J Nucl Med 2017 Jan-Mar;16(1):62-67
    Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital, Annexe, Mumbai, Maharashtra, India.
    Three cases of metabolic bone disease in the setting of metastatic neuroendocrine tumor (NET) are illustrated with associated etiopathologies.  One of these cases harbored mixed lesions in the form of vertebral metastasis (biopsy proven) while the other skeletal lesions were caused due to metabolic bone disease related to multiple parathyroid adenomas. While the metastatic lesion was positive on 68Ga-DOTATATE positron emission tomography-computed tomography (PET-CT), the lesions of metabolic bone disease were negative and the 18F-fluoride PET-CT demonstrated the features of metabolic bone scan. Read More

    Paraneoplastic Dermatomyositis with Cutaneous and Myopathic Disease Responsive to Adrenocorticotropic Hormone Therapy.
    J Clin Aesthet Dermatol 2017 Jan 1;10(1):57-62. Epub 2017 Jan 1.
    St. Barnabas Hospital Dermatology Residency, Bronx, New York;; Mount Sinai School of Medicine Manhattan, New York.
    Dermatomyositis is a myopathic or amyopathic autoimmune connective tissue disease that presents with classic dermatologic findings ranging from: poikilodermatous photosensitivity (shawl sign), eyelid edema and violaceous-pigmentation (heliotrope sign), lichenoid eruptions on the knuckles and elbows (Gottron's sign), periungual telangiectasias, and ragged cuticles (Samitz sign). Up to 30 percent of adult-onset cases of dermatomyositis may represent a paraneoplastic syndrome warranting a thorough work-up for malignancy. The authors present a case report of paraneoplastic dermatomyositis associated with triple negative, BRCA-1 positive, invasive intraductal carcinoma of the breast, whose myopathic and cuteanous symptoms were recalcitrant to high-dose corticosteroid therapy. Read More

    The crossroads between cancer immunity and autoimmunity: antibodies to self antigens.
    Front Biosci (Landmark Ed) 2017 Mar 1;22:1289-1329. Epub 2017 Mar 1.
    Dept. of Clinical Sciences and Translational Medicine, Faculty of Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy,
    The production of autoantibodies to self antigens is dependent on the failure of immune tolerance. Cancer cells express antigens which elicit a spontaneous immune response in cancer patients. The repertoire of autoantibodies found in cancer patients partly covers that of patients with autoimmune diseases. Read More

    Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration.
    Mol Neurodegener 2017 Feb 13;12(1):16. Epub 2017 Feb 13.
    Institute of Physiological Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
    Background: Neuroinflammation is associated with a wide range of neurodegenerative disorders, however the specific contribution to individual disease pathogenesis and selective neuronal cell death is not well understood. Inflammatory cerebellar ataxias are neurodegenerative diseases occurring in various autoimmune/inflammatory conditions, e.g. Read More

    Management of neuro-oncologic emergencies.
    Handb Clin Neurol 2017 ;141:715-741
    Neuro-Oncology Center, University of Virginia, Charlottesville, VA, USA. Electronic address:
    Patients with brain tumors and systemic malignancies are subject to diverse neurologic complications that require urgent evaluation and treatment. These neurologic conditions are commonly due to the tumor's direct effects on the nervous system, such as cerebral edema, increased intracranial pressure, seizures, spinal cord compression, and leptomeningeal metastases. In addition, neurologic complications can develop as a result of thrombocytopenia, coagulopathy, hyperviscosity syndromes, infection, immune-related disorders, and adverse effects of treatment. Read More

    [CXCL-13 as a biomarker in the diagnostics of neuroborreliosis].
    Nervenarzt 2017 Feb 9. Epub 2017 Feb 9.
    Abteilung für Neurologie, Universitätsklinikum St. Pölten, KLPU, Propst Führer-Straße 4, 3100, St. Pölten, Österreich.
    Background: The chemokine CXCL-13 is a potential intrathecal biomarker for neuroborreliosis (NB). According to the literature the sensitivity of CXCL-13 in the diagnostics of NB varies between 88% and 100% and the specificity between 63% and 99.7%. Read More

    Association between rheumatic diseases and cancer: results from a clinical practice cohort study.
    Intern Emerg Med 2017 Feb 8. Epub 2017 Feb 8.
    Division of Internal Medicine, Immunorheumatology Unit, "Maggiore della Carità" Hospital, Corso Mazzini 18, 28100, Novara, Italy.
    The association between cancer and immune-mediated rheumatic conditions is controversial, especially as far as polymyalgia rheumatica (PMR) is concerned. Furthermore, no clinical feature has been shown to be suggestive of a paraneoplastic rheumatic syndrome. With the present study, we aim to address both these issues. Read More

    Skin: A mirror of internal malignancy.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):214-222
    Department of Dermatology, Shree Krishna Hospital, Pramukh Swami Medical College, Karamsad, Gujarat, India.
    Skin manifestations are a reflection of many of the internal diseases. Sometimes, skin disease may be the only manifestation of the internal disease. Internal malignancies may give rise to a number of cutaneous manifestations through their immunological, metabolic, and metastatic consequences. Read More

    Polyneuropathy as Novel Initial Manifestation in a Case of "Nonsecretory" POEMS Syndrome with Sjögren's Syndrome.
    Case Rep Med 2017 4;2017:1276759. Epub 2017 Jan 4.
    Nursing Department, Huashan Hospital, Fudan University, Shanghai 200040, China.
    POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a paraneoplastic syndrome driven by plasma cell dyscrasias. We report a patient with novel initial manifestation of polyneuropathy, which was considered due to Sjögren's syndrome but with poor response to methylprednisolone (120 mg/d) and intravenous immunoglobulin (IVIg). Further investigation by imaging tests and following biopsy eventually confirmed the diagnosis of POEMS syndrome secondary to solitary plasmocytoma. Read More

    Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review.
    World J Gastroenterol 2017 Jan;23(2):366-372
    Mena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
    Vanishing bile duct syndrome (VBDS) has been described in different pathologic conditions including infection, ischemia, adverse drug reactions, autoimmune diseases, allograft rejection, and humoral factors associated with malignancy. It is an acquired condition characterized by progressive destruction and loss of the intra-hepatic bile ducts leading to cholestasis. Prognosis is variable and partially dependent upon the etiology of bile duct injury. Read More

    Successful treatment of tumour-induced osteomalacia after resection of an oral peripheral ossifying fibroma.
    BMJ Case Rep 2017 Jan 24;2017. Epub 2017 Jan 24.
    Department of Radiology, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
    Tumour-induced osteomalacia is a paraneoplastic syndrome wherein bone is affected by a hormone from a tumour that causes renal phosphate wasting and hypophosphataemia. Here, we present the case of a 31-year-old man who has been suffering from generalised bone pains and a spine deformity that led to loss of height. Pertinent findings are low serum phosphorus, low vitamin D and decreased bone mineral density. Read More

    Impact of chemotherapy on eosinophilia-associated advanced rectal cancer: A case report and review of the literature.
    Oncol Lett 2016 Dec 8;12(6):5269-5274. Epub 2016 Nov 8.
    Department of Cardiovascular and Gastroenterological Surgery, Kagoshima University Medical and Dental Hospital, Kagoshima 890-8544, Japan.
    The present study reports a case of eosinophilia-associated rectal cancer that was successfully stabilized using chemotherapy, and reviews the mechanisms of eosinophilia and the importance of chemotherapy. A 65-year-old man, who had previously been diagnosed with suspected rectal cancer, presented with the chief complaint of melena. Eosinophilia, abnormal blood coagulation, and elevated carcinoembryonic antigen and carbohydrate antigen 19-9 tumor marker levels were observed, and the patient was subsequently diagnosed with advanced rectal cancer accompanied by multiple lymph node metastases that extended from the para-aortic lymph nodes to the left axillary lymph nodes. Read More

    When dizziness becomes sinister: oropharyngeal carcinoma presenting as a paraneoplastic neurological disorder.
    BMJ Case Rep 2017 Jan 19;2017. Epub 2017 Jan 19.
    Edinburgh Cancer Research Centre, Edinburgh Cancer Centre, Edinburgh, UK.
    Paraneoplastic neurological disorders are uncommon presentations of head and neck cancers. We present a case of a 68-year-old male patient who presented with dizziness, nausea and memory problems. MRI of his brain showed bilateral cerebellar leptomeningeal enhancing signal abnormality with cervical lymphadenopathy. Read More

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