6,514 results match your criteria Paraneoplastic Diseases


Causes of chronic neuropathies: a single-center experience.

Neurol Sci 2019 Apr 18. Epub 2019 Apr 18.

Unit of Neurology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, via Álvaro del Portillo, 21, 00128, Rome, Italy.

Objectives: Chronic neuropathies are a common cause of neurological disability worldwide. However, few reports have evaluated, in real life, the prevalence of the several conditions which can cause it.

Patients And Methods: The authors reviewed informatic database for outpatient office to confirm identification of chronic neuropathy in a 3-year interval period. Read More

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http://link.springer.com/10.1007/s10072-019-03899-z
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http://dx.doi.org/10.1007/s10072-019-03899-zDOI Listing
April 2019
1 Read

The neurological syndromes associated with glutamic acid decarboxylase antibodies.

J Autoimmun 2019 Apr 15. Epub 2019 Apr 15.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA; University of Guanajuato, Mexico. Electronic address:

A number of neurological syndromes have been described in patients with positive serum antibodies (Abs) against the enzyme glutamic acid decarboxylase (GAD), the rate limiting step in the synthesis of GABA (γ-aminobutyric acid). These disorders include: classical stiff-person syndrome and variants, cerebellar ataxia, limbic and extra-limbic encephalitis, nystagmus/oculomotor dysfunction, drug-resistant epilepsy, paraneoplastic stiff-person syndrome and progressive encephalopathy with rigidity and myoclonus (PERM), the latter two are mainly related to amphiphysin and the glycine receptor Abs respectively; but patients may also have positive GAD-Abs. Although observations are consistent with an autoimmune response in these patients and there is evidence of GABAergic dysfunction in some cases; the pathogenic role of GAD-Abs in the nervous system has not been clarified and it is a matter of debate. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.007DOI Listing
April 2019
1 Read

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient With Antithyroid Peroxidase Antibodies and a Parotid Pleomorphic Adenoma.

Ochsner J 2019 ;19(1):59-62

The University of Queensland Faculty of Medicine, Ochsner Clinical School, New Orleans, LA.

Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an autoimmune disorder first described in 2007. It can cause severe neurologic and psychiatric symptoms, and patients often are misdiagnosed with a primary psychiatric disorder. Anti-NMDA-R encephalitis is an important differential diagnosis of psychosis, as the condition can be treated with the appropriate therapy. Read More

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http://www.ochsnerjournal.org/lookup/doi/10.31486/toj.18.011
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http://dx.doi.org/10.31486/toj.18.0115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447211PMC
January 2019
6 Reads

Risk factors for death and survival in paraneoplastic pemphigus associated with hematologic malignancies in adults.

J Am Acad Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Assistance Publique-Hôpitaux de Paris, Département de Dermatologie, Hôpital Saint-Louis, Paris, France; Université Paris-Diderot, Sorbonne Paris Cité, Paris, France. Electronic address:

Background: Paraneoplastic pemphigus (PNP) occurs more often in patients with hematologic malignancies (HMs) than in patients with solid cancer. Lung bronchiolitis obliterans (BO) is a severe complication of PNP.

Objective: To determine the precise clinical and biologic features of HM-associated PNP and identify factors associated with mortality and survival. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.03.043DOI Listing
April 2019
1 Read

Acute cerebellar ataxia: differential diagnosis and clinical approach.

Arq Neuropsiquiatr 2019 Mar;77(3):184-193

Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Unidade de Neurologia Geral e de Ataxias, São Paulo SP, Brasil.

Cerebellar ataxia is a common finding in neurological practice and has a wide variety of causes, ranging from the chronic and slowly-progressive cerebellar degenerations to the acute cerebellar lesions due to infarction, edema and hemorrhage, configuring a true neurological emergency. Acute cerebellar ataxia is a syndrome that occurs in less than 72 hours, in previously healthy subjects. Acute ataxia usually results in hospitalization and extensive laboratory investigation. Read More

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http://dx.doi.org/10.1590/0004-282X20190020DOI Listing
March 2019
1 Read

Antigenic Mimicry in Paraneoplastic Immune Thrombocytopenia.

Front Immunol 2019 22;10:523. Epub 2019 Mar 22.

Internal Medicine and Infectious Diseases Department, Haut Lévêque Hospital, University Hospital Centre of Bordeaux, Pessac, France.

The association of immune thrombocytopenia (ITP) with cancer has been reported, but the causality of tumor cells in paraneoplastic ITP pathogenesis and maintenance has never been established. We analyzed the unusual case of refractory ITP and coincident urothelial tumor of the kidney with circulating high titer anti-GPIIBIIIA autoantibodies. Intriguingly, after nephrectomy, the patient recovered fully and her anti-GPIIBIIIA autoantibodies disappeared. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439352PMC
March 2019
1 Read

Esophageal adenocarcinoma with leukemoid reaction: a case report.

J Cardiothorac Surg 2019 Apr 8;14(1):66. Epub 2019 Apr 8.

Department of Thoracic Surgery, Weihai Municipal Hospital, 70 Heping Road, Weihai, 264200, Shandong, China.

Background: Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm, and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome, unrelated to an infection or other diseases. Read More

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http://dx.doi.org/10.1186/s13019-019-0893-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454710PMC
April 2019
1 Read
1.018 Impact Factor

Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series.

Mult Scler Relat Disord 2019 Apr 1;31:97-100. Epub 2019 Apr 1.

Center for pathophysiology Toulouse Purpan, INSERM U1043, CNRS 5282, Université Toulouse III, 31024 Toulouse, France; CRC-SEP, Pôle Neurosciences, CHU de Toulouse, 31059 Toulouse, France.

Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory disease of the central nervous system, characterized by the presence of auto-antibodies directed against aquaporin-4 (AQP4) expressed on astrocyte end-feet. Despite NMOSD does not primarily belong to the spectrum of paraneoplastic neurological syndromes, rare cases of association with neoplasia have been outlined. Here, we report the association of NMOSD with ovarian teratoma in 3 cases. Read More

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http://dx.doi.org/10.1016/j.msard.2019.03.031DOI Listing
April 2019
1 Read

Motor neuron disease as a treatment responsive paraneoplastic neurological syndrome in patient with small cell lung cancer, anti-Hu antibodies and limbic encephalitis.

J Neurol Sci 2019 May 27;400:158-159. Epub 2019 Mar 27.

Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, University of Trieste, Trieste, Italy.

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http://dx.doi.org/10.1016/j.jns.2019.03.024DOI Listing

Peripheral Nerve Vasculitis: Classification and Disease Associations.

Neurol Clin 2019 May 18;37(2):303-333. Epub 2019 Mar 18.

Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA. Electronic address:

"The vasculitic neuropathies encompass a wide range of disorders characterized by ischemic injury to the vasa nervorum. Patients with vasculitic neuropathies develop progressive, painful sensory or sensorimotor deficits that are typically multifocal or asymmetric. Depending on the underlying etiology, the vasculitis may be confined to the peripheral nervous system; may be one manifestation of a primary systemic vasculitis; or one manifestation of a systemic vasculitis that is secondary to underlying connective tissue disease, drug exposure, viral infection, or paraneoplastic syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619193001
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http://dx.doi.org/10.1016/j.ncl.2019.01.013DOI Listing
May 2019
4 Reads

Hepatic Manifestations of Lymphoproliferative Disorders.

Clin Liver Dis 2019 May 2;23(2):293-308. Epub 2019 Mar 2.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Hepatic abnormalities in patients with lymphoproliferative disorders are common and can occur from direct infiltration by abnormal cells, bile duct obstruction, paraneoplastic syndrome, hemophagocytic syndrome, drug-induced liver injury, opportunistic infections, and reactivation of viral hepatitis. Hepatic involvement by lymphoma is often in association with systemic disease and rarely seen as a primary hepatic lymphoma. Vanishing bile duct syndrome is a well-known complication of Hodgkin disease. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.010DOI Listing
May 2019
1 Read

Acanthosis nigricans: To be or not to be afraid.

Oncol Lett 2019 May 19;17(5):4133-4138. Epub 2018 Nov 19.

Department of Cellular and Molecular Biology and Histology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Acanthosis nigricans (AN), a skin disorder with high prevalence, represents a dermatological condition with esthetic implications, but otherwise mild symptoms. For any clinician, it is in fact the tip of the iceberg, leading him/her to investigate what lies beneath the surface, since AN points to a systemic problem or disease: metabolic disorder (most frequently), endocrine syndrome, medication side effects, malignancy, and genetic factors. Sometimes, it is the first observed sign of a malignancy or of diabetes mellitus, especially in patients with chronic metabolic disorder; therefore, it is not to be taken lightly. Read More

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http://dx.doi.org/10.3892/ol.2018.9736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444334PMC
May 2019
4 Reads

IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration.

JCI Insight 2019 Apr 4;4(7). Epub 2019 Apr 4.

Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France.

Paraneoplastic neurological disorders result from an autoimmune response against neural self-antigens that are ectopically expressed in neoplastic cells. In paraneoplastic disorders associated to autoantibodies against intracellular proteins, such as paraneoplastic cerebellar degeneration (PCD), current data point to a major role of cell-mediated immunity. In an animal model, in which a neo-self-antigen was expressed in both Purkinje neurons and implanted breast tumor cells, immune checkpoint blockade led to complete tumor control at the expense of cerebellum infiltration by T cells and Purkinje neuron loss, thereby mimicking PCD. Read More

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https://insight.jci.org/articles/view/127001
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http://dx.doi.org/10.1172/jci.insight.127001DOI Listing
April 2019
2 Reads

Incidental papillary thyroid cancer diagnosis in patient with adult-onset Still's disease-like manifestations.

Authors:
R Tirri D Capocotta

Reumatismo 2019 Apr 1;71(1):42-45. Epub 2019 Apr 1.

Unit of Rheumatology, Department of Clinical and Sperimental Internal Medicine, Luigi Vanvitelli University, Napoli.

Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized primarily by a triad consisting of daily fever, arthritis and maculopapular exanthema. The pathogenesis and etiology of AOSD are unknown and the diagnosis, which can be very challenging, is often made by exclusion. Here, we report a case of a 61-year-old woman with a history of mild psoriatic arthritis, fever, arthritis and maculopapular exanthema. Read More

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http://dx.doi.org/10.4081/reumatismo.2019.1118DOI Listing
April 2019
1 Read

Degenerative and acquired sporadic adult onset ataxia.

Neurol Sci 2019 Mar 29. Epub 2019 Mar 29.

Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.

The diagnosis of sporadic adult onset ataxia is a challenging task since a large collection of hereditary and non-hereditary disorders should be taken into consideration. Sporadic adult onset ataxias include degenerative non-hereditary, hereditary, and acquired ataxias. Multiple system atrophy and idiopathic late cerebellar ataxia are degenerative non-hereditary ataxias. Read More

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http://dx.doi.org/10.1007/s10072-019-03856-wDOI Listing
March 2019
1 Read

Palisaded Neutrophilic Granulomatous Dermatitis Leading to Diagnosis of Hodgkin Lymphoma: Report of Rare Case and Literature Review of Paraneoplastic Granulomatous Dermatitides.

Am J Dermatopathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Dermatology, University of Wisconsin, Madison, WI.

Palisaded neutrophilic granulomatous dermatitis (PNGD) presents as skin-colored to erythematous papules symmetrically distributed on extensor extremities. Histologically, interstitial and/or palisaded granulomatous infiltrates are present with neutrophils and leukocytoclasis. Together with interstitial granulomatous dermatitis (IGD), PNGD is considered a reactive granulomatous dermatitis to a systemic trigger including connective tissue disease, infection, medication reaction, and less commonly malignancy. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001411DOI Listing
April 2019
1 Read

IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Nephrology, Tokyo Teishin Hospital, Japan.

An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination revealed the presence of renal cell carcinoma, which was surgically resected and confirmed to be interleukin-6-positive by immunohistochemistry. Read More

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http://dx.doi.org/10.2169/internalmedicine.2000-18DOI Listing
March 2019
2 Reads

[Analysis of Small Cell Lung Cancer with Paraneoplastic Limbic Encephalitis].

Authors:
Mingyi Di Li Zhang

Zhongguo Fei Ai Za Zhi 2019 Mar;22(3):132-136

Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing 100730, China.

Background: The aim of this study was to investigate the clinical features of paraneoplastic limbic encephalitis (PLE) with small cell lung cancer (SCLC) and improve clinical diagnosis and treatment.

Methods: The clinical data of 15 patients with SCLC combined with PLE from January 1980 to May 2017 were collected from Beijing Union Hospital. Their symptoms and laboratory data were analyzed and the prognosis of the patients was followed. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.03.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441114PMC
March 2019
1 Read

Case report: Gastric cancer-associated membranous nephropathy that recurred after complete remission and formation of peritoneal dissemination.

Clin Case Rep 2019 Mar 6;7(3):515-519. Epub 2019 Feb 6.

Department of Nephrology Ikeda City Hospital Ikeda Japan.

Membranous nephropathy associated with malignant neoplasm may remit completely with treatment of the underlying disease. In such cases, recurrence is very rare. However, after a recurrence, attention should be paid to the possible recurrence of the underlying disease. Read More

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http://dx.doi.org/10.1002/ccr3.2002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406138PMC

Outcomes Associated With Sustained-Release Intraocular Fluocinolone Implants in a Case of Melanoma-Associated Retinopathy Treated Without Systemic Immunosuppression.

JAMA Ophthalmol 2019 Mar 21. Epub 2019 Mar 21.

Royal Surrey County Hospital, Guildford, United Kingdom.

Importance: Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome in which antiretinal antibodies crossreact with retinal ON-bipolar cells, resulting in night blindness and progressive visual field loss. Current therapeutic options include cytoreductive surgery in combination with immunoglobulin, corticosteroids, or plasmapheresis, but their effectiveness is limited and may be contraindicated, given the possible protective role of circulating autoantibodies against metastatic spread. We report 3-year follow-up of the first case (to our knowledge) of MAR treated with intravitreal long-acting steroid implants. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0284DOI Listing

Paraneoplastic syndromes: Definitions, classification, pathophysiology and principles of treatment.

Authors:
Kristin Henry

Semin Diagn Pathol 2019 Feb 1. Epub 2019 Feb 1.

Imperial College London, Charing Cross Hospital Campus, Department of Histopathology, Fulham Place Road, London W6 8RF, United Kingdom. Electronic address:

Paraneoplastic syndromes (PNS) are rare clinical syndromes due to the systemic effects of tumours; they are unrelated to tumour size, invasiveness or metastases. Recent years have seen considerable advances leading to improved understanding of their pathophysiology and increased recognition of new PNS entities and PNS associated tumours. While of paramount importance, diagnosis is still frequently missed or delayed. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.002DOI Listing
February 2019
1 Read

Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis.

Acta Neuropathol Commun 2019 Mar 11;7(1):38. Epub 2019 Mar 11.

Institut NeuroMyogène, Equipe Synaptopathies et Autoanticorps (SynatAc), INSERM U1217/UMR CRS 5310, Lyon, France.

Encephalitis with anti-NMDAR antibodies (NMDAR-E) is a severe autoimmune neurological disorder, defined by a clinical presentation of encephalitis and the presence of IgG targeting the GluN1 subunit of NMDA receptors in the CSF. An underlying ovarian teratoma is commonly associated with this autoimmune disease suggesting a role of the tumor in immunopathogenesis. In this study, we characterized the salient histopathological features of 27 ovarian teratomas associated with NMDAR-E (3 immature and 24 mature teratomas) and 40 controls without associated encephalitis. Read More

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http://dx.doi.org/10.1186/s40478-019-0693-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410529PMC
March 2019
2 Reads

Spontaneous resolution of dermatomyositis associated with fallopian-tube carcinoma following staging surgery: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14530

Department of Gynecologic Oncology, West China Second Hospital, Sichuan University.

Rationale: Paraneoplastic dermatomyositis (DM) is an inflammatory disease of the connective tissue caused by immunologic events in the presence of malignant tumors, which are typically related to ovarian, pancreatic, stomach, and colon cancer. Traditional treatment of paraneoplastic DM includes combination therapy for the underlying malignancy with systemic steroids.

Patient Concerns: A 41-year-old woman presented with facial erythema and myalgia of the extremities. Read More

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http://dx.doi.org/10.1097/MD.0000000000014530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417515PMC
March 2019
1 Read

A report on paraneoplastic motor neuron disease.

Chin Med J (Engl) 2019 03;132(6):719-722

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

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http://dx.doi.org/10.1097/CM9.0000000000000128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416018PMC

Paraneoplastic relapsing minimal change disease associated with type A thymoma in an elderly patient: A case report and literature review.

Med J Malaysia 2019 Feb;74(1):97-98

National University Health System, Department of Medicine, Singapore.

Thymoma is a rare mediastinal tumour that can be accompanied by different paraneoplastic syndromes. Here we report a case of Type A thymoma associated with relapsing minimal change disease (MCD). This case highlights: (1) The need to balance rapid prednisolone weaning against risk for relapse in an elderly patient at risk for steroid-induced complications. Read More

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February 2019
1 Read

Cancer and motor neuron disease-causal or coincidental? Two contrasting cases.

Neurol Sci 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurology, Aberdeen Royal Infirmary, Foresterhill Road, Aberdeen, AB25 2ZN, UK.

Introduction: Motor neuron disease (MND) can occur in patients with cancer, but there is minimal evidence that this is more than by chance. We contrast two cases of motor neuronopathies occurring in the context of systemic malignancy and argue that in one case the cause was most likely paraneoplastic, while in the other it was not. CASE 1: A 61-year-old woman developed progressive walking difficulties over 9 months with weakness and stiffness in her legs. Read More

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http://link.springer.com/10.1007/s10072-019-03784-9
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http://dx.doi.org/10.1007/s10072-019-03784-9DOI Listing
March 2019
7 Reads

Neuronal Autoantibodies Associated with Cognitive Impairment in Melanoma Patients.

Ann Oncol 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurology, Charité - Universitätsmedizin Berlin, Germany.

Background: Cancer-related cognitive impairment is an important complication in cancer patients, yet the underlying mechanism remains unknown. Over the last decade, the field of paraneoplastic neurological syndromes has been dramatically changed by the discovery of new neuronal autoantibodies, some of them associated with cognitive impairment. We aimed to assess the prevalence of neuronal autoantibodies in melanoma patients and their association with neurological and cognitive dysfunction. Read More

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http://dx.doi.org/10.1093/annonc/mdz083DOI Listing
March 2019
2 Reads

Paraneoplastic autoimmunity and small-cell lung cancer: Neurological and serological accompaniments.

Thorac Cancer 2019 Apr 27;10(4):1001-1004. Epub 2019 Feb 27.

Department of Neurology, Mayo Clinic, Rochester, USA.

Paraneoplastic neurological autoimmunity is often associated with small-cell lung cancer (SCLC), a highly malignant neuroendocrine tumor. Paraneoplastic autoimmunity often correlates with longer survival. We describe the paraneoplastic neurological manifestations of patients with SCLC with and without SCLC-predictive autoantibodies and the correlation between autoimmunity and survival. Read More

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http://doi.wiley.com/10.1111/1759-7714.13009
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http://dx.doi.org/10.1111/1759-7714.13009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449272PMC
April 2019
9 Reads

Non-paraneoplastic autoimmune retinopathy: multimodal testing characteristics of 13 cases.

J Ophthalmic Inflamm Infect 2019 Feb 26;9(1). Epub 2019 Feb 26.

Department of Ophthalmology and Visual Sciences, University of Wisconsin, 2880 University Avenue, Madison, WI, 53705, USA.

Background: Non-paraneoplastic autoimmune retinopathy (npAIR) is a rare autoimmune disease that primarily affects retinal photoreceptor function and results in profound and often times permanent vision loss. Delay in diagnosis and treatment initiation may contribute to the poor visual prognosis.

Methods: A retrospective chart review of all patients diagnosed with autoimmune retinopathy at the University of Wisconsin-Madison Eye Clinics between January 2012 and January 2017 was performed. Read More

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http://dx.doi.org/10.1186/s12348-019-0171-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391508PMC
February 2019
1 Read

Treatment-refractory paraneoplastic opsoclonus-myoclonus syndrome in a patient with small-cell carcinoma of the lung.

J Oncol Pharm Pract 2019 Feb 22:1078155219831366. Epub 2019 Feb 22.

1 Department of Internal Medicine, Medical Oncology Unit, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey.

Opsoclonus-myoclonus syndrome is a rare disease and traditionally described as "dancing eyes, dancing feet syndrome." It is characterized by opsoclonus (oscillations of the eyes in either horizontally or vertically) and myoclonus (spontaneous jerky movements of the limbs and trunk). There are numerous etiological factors defined such as paraneoplastic, para-infectious, toxic-metabolic, and idiopathic causes. Read More

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http://dx.doi.org/10.1177/1078155219831366DOI Listing
February 2019
1 Read

Paraneoplastic opsoclonus-myoclonus syndrome as a rare presentation of breast cancer.

J Surg Case Rep 2019 Feb 8;2019(2):rjy365. Epub 2019 Feb 8.

Department of Neurology, Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo 9700, Portugal.

Opsoclonus-myoclonus paraneoplastic syndrome is a medical condition that includes opsoclonus along with diffuse or focal body myoclonus and truncal titubation with or without ataxia and other cerebellar signs. This rare neurological syndrome is poorly understood and can result in long-term cognitive, behavioral and motor sequelae. We report a case of a 49-year-old woman with anti-Ri antibody opsoclonus-myoclonus syndrome and an invasive ductal carcinoma with axillary nodes involvement. Read More

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http://dx.doi.org/10.1093/jscr/rjy365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368204PMC
February 2019

Isolated recurrent myelitis in a persistent MOG positive patient.

Mult Scler Relat Disord 2019 May 13;30:163-164. Epub 2019 Feb 13.

Department of Neurology, Tel-Aviv Sourasky Medical Center, Weizman 6 Street, Tel-Aviv, 6423906, Israel; Autoimmune Neurology Laboratory, Tel Aviv Sourasky Medical Center, Weizman 6 Street, Tel-Aviv, 6423906, Israel; Autoimmune encephalitis and paraneoplastic syndromes clinic, Tel-Aviv Sourasky Medical Center, Weizman 6 Street, Tel-Aviv, 6423906, Israel.

MOG-Ab positive CNS demyelination typically involves the optic nerve and spinal cord. Recurrent episodes of myelitis without optic neuritis are very rare and according to current literature review represent about 3-5% of positive MOG-Ab cases. We report a 30-year-old woman with positive serum MOG-Ab suffering two discrete episodes of transverse myelitis without ophthalmic involvement. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.016DOI Listing

Tumor-induced osteomalacia.

Osteoporos Sarcopenia 2018 Dec 12;4(4):119-127. Epub 2018 Dec 12.

Department of Endocrinology, Key Laboratory of Endocrinology, The National Commission of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic syndrome characterized by hypophosphatemia resulting from decreased tubular phosphate reabsorption, with a low or inappropriately normal level of active vitamin D. The culprit tumors of TIO could produce fibroblast growth factor 23 which plays a role in regulating renal Pi handling and 25-hydroxyvitamin D 1α-hydroxylase activity. Chronic hypophosphatemia could eventually lead to inadequate bone mineralization, presenting as osteomalacia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24055255183009
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http://dx.doi.org/10.1016/j.afos.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372818PMC
December 2018
5 Reads

Paraneoplastic Eosinophilic Dermatosis in a Case of Chronic Lymphocytic Leukemia.

Indian Dermatol Online J 2019 Jan-Feb;10(1):61-63

Department of Skin and VD, SBH Govt. Medical College, Dhule, Department of Skin and VD, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

Eosinophilic dermatosis of hematologic malignancy is a rare paraneoplastic manifestation particularly associated with chronic lymphocytic leukemia (CLL).Clinically, it presents as a peculiar polymorphic pruritic eruption with characteristic histological findings of superficial and deep dense perivascular infiltrate of lymphocytes and eosinophils without any vasculitis. Although it has been reported intermittently with different names, there is paucity of reports of this condition in Indian literature. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_121_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362748PMC
February 2019

Increased Galectin-1 Expression in Thymic Epithelial Tumors.

Clin Lung Cancer 2018 Dec 21. Epub 2018 Dec 21.

Department of Radiation Oncology, Stanford University School of Medicine Stanford Cancer Institute, Stanford, CA.

Introduction: Thymic epithelial tumors (TET) are rare malignancies with a paucity of data on biology and therapeutics. Galectin-1 is a member of the β-galactoside binding protein family and has been shown to mediate tumor growth via modulation of immune cell function. This study examined galectin-1 expression in TET. Read More

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http://dx.doi.org/10.1016/j.cllc.2018.12.005DOI Listing
December 2018

Gynecological neoplasms associated with paraneoplastic hypercalcemia.

Authors:
D Lim E Oliva

Semin Diagn Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Approximately 5% of gynecological malignancies are associated with paraneoplastic hypercalcemia. Awareness of its association with certain tumor types allows for earlier disease detection and facilitates monitoring of treatment response and disease recurrence. We review the salient clinicopathological features, differential diagnosis and management issues in some of these gynecological tumors, namely: small cell carcinoma, hypercalcemic type; ovarian clear cell carcinoma, dysgerminoma and juvenile granulosa cell tumors. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.003DOI Listing
February 2019
1 Read

Aquaporin-4 antibody positive short transverse myelitis associated with breast cancer.

Mult Scler Relat Disord 2019 May 8;30:119-122. Epub 2019 Feb 8.

Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS). A typical finding on spinal magnetic resonance imaging (MRI) of NMOSD is longitudinally extensive transverse myelitis (LETM). However, patients with NMOSD presenting with short-segment transverse myelitis (STM) during myelitis attacks associated with breast cancer are uncommon. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.011DOI Listing
May 2019
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Severe Refractory Paraneoplastic Mucous Membrane Pemphigoid Successfully Treated With Rituximab.

Front Med (Lausanne) 2019 29;6. Epub 2019 Jan 29.

Department of Dermatology, Venerology and Allergology, Charité- Universitätsmedizin Berlin, Berlin, Germany.

Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease of the mucous membranes, which can cause irreversible scarring and is discussed to be associated with cancer, if laminin-332-autoantibodies are present. MMP with severe ocular and laryngeal involvement is difficult to treat and can be treatment-refractory to conventional immunosuppressant therapy. A 67-year-old man with a history of prostate cancer presented to our clinic with sore throat, intraoral bullae, odynophagia, dysphonia, exertional dyspnea, and erosions of the glans penis. Read More

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http://dx.doi.org/10.3389/fmed.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362419PMC
January 2019
12 Reads

Dronabinol for the Treatment of Paraneoplastic Night Sweats in Cancer Patients: A Report of Five Cases.

J Palliat Med 2019 Feb 13. Epub 2019 Feb 13.

4 Palliative Medicine, Stanford University School of Medicine, Stanford, California.

Background: Night sweats significantly impact the quality of life for cancer patients and are often resistant to treatment. Cannabinoids have been shown to modulate cytokine activity and produce hypothermia in animal models, suggesting that they may be a promising candidate for palliation of night sweats in patients with oncologic disease.

Objective: Assess efficacy of the oral cannabinoid, dronabinol, for palliation of night sweats in cancer patients. Read More

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http://dx.doi.org/10.1089/jpm.2018.0551DOI Listing
February 2019
1 Read

Acute Anaemia: A Challenging Diagnosis.

Eur J Case Rep Intern Med 2018 27;5(9):000956. Epub 2018 Sep 27.

Internal Medicine Department, Hospital São Francisco Xavier, Lisbon, Portugal.

Acute anaemia is characterized by a reduction in the number of red blood cells, haemoglobin levels or haematocrit. By far the most common aetiology is haemorrhage, but in its absence other less frequent causes should be considered. The authors present the case of a 42-year-old man with a diagnosis of glucose-6-phosphate deficiency and progressing gastric signet ring cell carcinoma, who was admitted to the internal medicine department for symptomatic back pain control. Read More

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http://dx.doi.org/10.12890/2018_000956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346818PMC
September 2018
3 Reads

Remitting Seronegative Symmetrical Synovitis with Pitting Oedema as the First Manifestation of an Adenocarcinoma of the Caecum.

Eur J Case Rep Intern Med 2018 27;5(12):000976. Epub 2018 Dec 27.

Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) is a rare syndrome that affects the elderly. Although the aetiology is not fully understood, it has been related to multiple diseases including cancer. We present the case of an 80-year-old man with a full spectrum of signs and symptoms compatible with RS3PE: sudden onset of bilateral polyarthralgia of the metacarpophalangeal and proximal interphalangeal joints, oedema of the dorsum of the hands, increased inflammatory markers and seronegative rheumatoid factor. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/976
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http://dx.doi.org/10.12890/2018_000976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346972PMC
December 2018
4 Reads

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
15 Reads

Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate.

Oncotarget 2019 Jan 1;10(1):17-29. Epub 2019 Jan 1.

Department of Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Background: Neuroendocrine carcinomas of the prostate (NEPCs) are rare tumors with poor prognosis. While platinum and etoposide-based chemotherapy regimens (PE) are commonly applied in first-line for advanced disease, evidence for second-line therapy and beyond is very limited.

Methods: Retrospective analysis of all patients with NEPCs including mixed differentiation with adenocarcinoma component and well differentiated neuroendocrine tumors (NETs, carcinoids) at two high-volume oncological centers between 12/2000 and 11/2017. Read More

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http://www.oncotarget.com/fulltext/26523
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http://dx.doi.org/10.18632/oncotarget.26523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343754PMC
January 2019
13 Reads

Recent Updates on the Relationship between Cancer and Autoimmune Pancreatitis.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Autoimmune pancreatitis (AIP) is now considered a pancreatic manifestation of a newly proposed disease condition, IgG4-related disease (IgG4-RD). IgG4-RD is characterized by enhanced IgG4 antibody responses and multiple organ involvements. Recent epidemiological studies have addressed the incidence of cancer in patients with AIP and/or IgG4-RD. Read More

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http://dx.doi.org/10.2169/internalmedicine.2210-18DOI Listing
February 2019
2 Reads
0.967 Impact Factor

Pyoderma gangrenosum: a presenting sign of myelodysplastic syndrome in undiagnosed Fanconi anemia.

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.

A 26-year-old man with a history of congenital bilateral microtia, unilateral renal agenesis, left aural atresia, and right external auditory canal occlusion admitted for right rib cartilage graft harvest and left ear re-construction. Following surgery, an ulceration with violaceous borders and a yellow fibrinous base unresponsive to broad-spectrum antibiotics developed at the harvest site. The wound was expanding and not responsive to systemic broad-spectrum antibiotics. Read More

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January 2019
7 Reads

A rapidly progressive motor neuron disease associated to a natural killer cells leukaemia.

J Neurol Sci 2019 Mar 17;398:117-118. Epub 2019 Jan 17.

IRCCS Centro Neurolesi Bonino Pulejo, Palermo, Italy.

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http://dx.doi.org/10.1016/j.jns.2019.01.029DOI Listing

Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection.

Methods Mol Biol 2019 ;1941:225-255

Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to an underlying neoplasm. Some of these paraneoplastic encephalitides express serum antibodies, but these were not thought to be pathogenic but instead have a T-cell-mediated pathophysiology. Over the last two decades, several pathogenic antibodies against neuronal surface antigens have been described in autoimmune encephalitis, which are amenable to immunotherapy. Read More

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http://dx.doi.org/10.1007/978-1-4939-9077-1_15DOI Listing
January 2019
2 Reads

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors.

Front Immunol 2018 10;9:3112. Epub 2019 Jan 10.

Medical School, Montpellier University, Montpellier, France.

Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03112
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http://dx.doi.org/10.3389/fimmu.2018.03112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335319PMC
January 2019
10 Reads

[An unusual cause of kidney disease in a diabetic patient].

Rev Med Liege 2019 Jan;74(1):15-19

Service de Néphrologie, CHU Sart Tilman, Liège, Belgique.

Diabetic nephropathy is a complication of diabetes that affects 25-40 % of diabetic patients. This complication is usually associated with other microangiopathic disorders. We describe a case of a patient suffering from type 2 diabetes with proteinuria, and no signs of retinopathy. Read More

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January 2019
3 Reads

Peliosis hepatis associated with follicular lymphoma with a rise in vascular endothelial growth factor and anaemia of inflammation.

Ecancermedicalscience 2018 20;12:882. Epub 2018 Nov 20.

Haematology Department, Virgen del Puerto Hospital, Paraje de Valcorchero s/n, 10600 Plasencia, Spain.

Follicular lymphoma does not usually present with associated paraneoplastic syndromes. We describe the case of a patient diagnosed with follicular lymphoma when investigating anaemia of chronic disease/inflammation and who, during her clinical course, developed peliosis hepatis. We have been able to confirm the similarity between the symptoms, the tumour's biology, the anaemia and peliosis, with the behaviour of endothelial growth factor, interleukins and iron metabolism disorders, which were normalised with treatment. Read More

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http://dx.doi.org/10.3332/ecancer.2018.882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345076PMC
November 2018
1 Read