7,305 results match your criteria Paraneoplastic Diseases

Hodgkin Lymphoma Associated Retinopathy: Report of a Case.

Ocul Immunol Inflamm 2021 May 13:1-3. Epub 2021 May 13.

Université de Paris, Department of Ophthalmology, Hôpital Cochin, Paris, France.

: To report a case of Hodgkin lymphoma (HL) associated retinopathy.: Single-case, retrospective review of ophthalmological and systemic manifestations.: A bilateral panuveitis in a 17-year-old Caucasian woman led to the diagnosis of HL. Read More

View Article and Full-Text PDF

Vasculitis and Breast Cancer: Mind the Hint.

Case Rep Oncol 2021 Jan-Apr;14(1):550-560. Epub 2021 Mar 22.

Internal Medicine Department, Hospital Beatriz Ângelo, Loures, Portugal.

Diffuse alveolar haemorrhage related to an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis is an extremely rare form of presentation of breast cancer. Here we report the case of a 77-year-old woman with a histological diagnosis of a papillary ductal carcinoma of the breast presenting with a diffuse alveolar haemorrhage secondary to a perinuclear ANCA-associated vasculitis. To our knowledge, this is the first case ever reported of a diffuse alveolar haemorrhage related to an ANCA-associated small vessel vasculitis as a form of presentation of breast cancer. Read More

View Article and Full-Text PDF

Beneficial autoimmunity improves cancer prognosis.

Nat Rev Clin Oncol 2021 May 11. Epub 2021 May 11.

Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.

Many tumour antigens that do not arise from cancer cell-specific mutations are targets of humoral and cellular immunity despite their expression on non-malignant cells. Thus, in addition to the expected ability to detect mutations and stress-associated shifts in the immunoproteome and immunopeptidome (the sum of MHC class I-bound peptides) unique to malignant cells, the immune system also recognizes antigens expressed in non-malignant cells, which can result in autoimmune reactions against non-malignant cells from the tissue of origin. These autoimmune manifestations include, among others, vitiligo, thyroiditis and paraneoplastic syndromes, concurrent with melanoma, thyroid cancer and non-small-cell lung cancer, respectively. Read More

View Article and Full-Text PDF

Paraneoplastic pemphigus caused by pre-existing stroma-rich variant of Castleman disease: from a pathologist's point of view.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Department of Cellular Pathology, North Bristol NHS Trust, Westbury on Trym, UK.

A young woman presented with mucocutaneous blisters and ulcerating lesions, and was diagnosed with erythrodermic pemphigus complicated by bronchiolitis obliterans. Her clinical condition did not improve on immunosuppressive therapy. She had a history of an asymptomatic retroperitoneal mass, presumed to be a dermoid cyst, followed up clinically. Read More

View Article and Full-Text PDF

RFC1 expansions are a common cause of idiopathic sensory neuropathy.

Brain 2021 May 9. Epub 2021 May 9.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.

After extensive evaluation, one-third of patients affected by polyneuropathy remain undiagnosed and are labelled as having chronic idiopathic axonal polyneuropathy, which refers to a sensory or sensory-motor, axonal, slowly progressive neuropathy of unknown origin. Since a sensory neuropathy/neuronopathy is identified in all patients with genetically confirmed RFC1 cerebellar ataxia, neuropathy, vestibular areflexia syndrome, we speculated that RFC1 expansions could underlie a fraction of idiopathic sensory neuropathies also diagnosed as chronic idiopathic axonal polyneuropathy. We retrospectively identified 225 patients diagnosed with chronic idiopathic axonal polyneuropathy (125 sensory neuropathy, 100 sensory-motor neuropathy) from our general neuropathy clinics in Italy and the UK. Read More

View Article and Full-Text PDF

Patient with respiratory distress, facial oedema and refractory hypokalaemia.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Medical Unit, National Hospital for Respiratory Disease, Welisara, Sri Lanka.

Small cell lung carcinoma, when associated with co-occurrence of complications such as paraneoplastic syndrome and superior vena cava syndrome, poses a greater management challenge to the clinical team. We report a 56-year-old man who was eventually diagnosed with stage III small cell lung carcinoma, presenting with respiratory distress, facial and upper body oedema, proximal muscle weakness, hypokalaemia, new-onset hypertension and hyperglycaemia. His medical management was complicated by associated superior vena cava syndrome and Cushing's syndrome leading to refractory hypokalemia, immunosuppression and depression. Read More

View Article and Full-Text PDF

Thymic Carcinoma with Multiple Paraneoplastic Disorders.

Am J Med Sci 2021 May 4. Epub 2021 May 4.

2(nd) Academic Department of Internal Medicine, Medical School, National & Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece. Electronic address:

Thymic neoplasms are rare and may run an indolent course. Among them, thymic epithelial carcinoma is exceptional as it may be presented with extensive local invasion and distant metastases. There is a wide spectrum of autoimmune/paraneoplastic syndromes associated with thymic tumors including autoimmune diseases, some of which may precede the diagnosis of thymoma. Read More

View Article and Full-Text PDF

Commenting on Paraneoplastic Arthritides: Insights to Pathogenesis, Diagnostic Approach, and Treatment.

J Clin Rheumatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy Division of Internal Medicine, "AOU Maggiore della Carità," Novara, Italy CAAD, Centre for Autoimmune and Allergic Diseases, Novara, Italy Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy Division of Internal Medicine, "AOU Maggiore della Carità," Novara, Italy CAAD, Centre for Autoimmune and Allergic Diseases, Novara, Italy.

View Article and Full-Text PDF

Pathogenesis, diagnosis and treatment of paraneoplastic neurologic syndromes.

Franz Blaes

Expert Rev Neurother 2021 May 7. Epub 2021 May 7.

Department of Neurology, KKH Gummersbach, Wilhelm-Breckow-Allee 20, 51643 Gummersbach, Germany.

Introduction: Paraneoplastic neurological syndromes (PNS) are a rare heterogeneous group of neurological diseases associated with tumors. These syndromes are the result of a cross-reactive immune response against antigens shared by the tumor and the nervous system. The discovery of an increasing number of autoantigens and the identification of tumoral factors leading to a substantial antitumoral immune response makes this topic highly innovative. Read More

View Article and Full-Text PDF

Paraneoplastic neuromyelitis optica spectrum disorder associated with malignant melanoma: A case report.

Thorac Cancer 2021 May 5. Epub 2021 May 5.

Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.

Neuromyelitis optica spectrum disorders (NMOSDs) are autoimmune demyelinating diseases involving the central nervous system, affecting the spinal cord and optic nerves. There are few reports of paraneoplastic NMOSD associated with malignant melanoma. Here, we report a rare case of anti-aquaporin 4 (AQP4) antibody-positive NMOSD associated with malignant melanoma. Read More

View Article and Full-Text PDF

Granuloma annulare - is it a paraneoplastic condition for malignant lymphoma?

J Dtsch Dermatol Ges 2021 May 5. Epub 2021 May 5.

Department of Dermatology, Allergology and Venereology, Saarland University Hospital, Homburg/Saar.

In recent years, an association between granuloma annulare and the occurrence of malignant cutaneous lymphomas in the sense of a facultative paraneoplasia has been observed several times. The aim of the present work is to provide an overview of the currently available literature on granuloma annulare as well as an analysis of its association with cutaneous lymphomas. Using the example of two patients with granuloma annulare and associated cutaneous lymphomas, we would like to sensitize clinically active dermatologists and dermatopathologists to the possible association between these two diseases. Read More

View Article and Full-Text PDF

Encephalitis with autoantibodies against the glutamate kainate receptors GluK2.

Ann Neurol 2021 May 5. Epub 2021 May 5.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Objective: To report the identification of antibodies against the glutamate kainate receptor subunit 2 (GluK2-abs) in patients with autoimmune encephalitis, and describe the clinical-immunological features and antibody effects.

Methods: Two sera from 8 patients with similar rat brain immunostaining were used to precipitate the antigen from neuronal cultures. A cell-based assay (CBA) with GluK2-expressing HEK293 cells was used to assess 596 patients with different neurological disorders, and 23 healthy controls. Read More

View Article and Full-Text PDF

Neuromyelitis optica spectrum disorder as a paraneoplastic syndrome: a rare and challenging diagnosis.

BMJ Case Rep 2021 May 4;14(5). Epub 2021 May 4.

Neurology Department, Morriston Hospital, Swansea, UK.

Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon antibody-mediated disease of the central nervous system, often associated with aquaporin-4 antibodies (AQP4-Ab). NMOSD may present as a subacute myelopathy, progressing over days with MRI revealing a contiguous inflammatory lesion of the spinal cord, ≥3 vertebral segments, a longitudinally extensive transverse myelitis. We describe an unusual paraneoplastic form of AQP4-Ab NMOSD that developed in a patient with an advanced diffuse large B-cell lymphoma. Read More

View Article and Full-Text PDF

Aβ-related Angiitis (ABRA)-A Rare Paraneoplastic Cause of Cerebral Vasculitis in a Young Patient: A Pathway From Unspecific Neurological Symptoms to Final Diagnosis.

Neurologist 2021 May 5;26(3):103-107. Epub 2021 May 5.

Department of Neurology, City of Cologne Municipal Hospitals, Medical Center Cologne-Merheim.

Introduction: Aβ-related angiitis (ABRA) is a very rare disease entity with combined features of cerebral amyloid angiopathy and primary angiitis of the CNS. However, the pathogenesis has not been conclusively described yet. Interestingly though, a possible paraneoplastic origin has been reported in the past. Read More

View Article and Full-Text PDF

Paraneoplastic vs. non-paraneoplastic anti-Hu associated dysmotility: a case series and literature review.

J Neurol 2021 May 2. Epub 2021 May 2.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Objectives: This work aimed to report the demographic and clinical characteristics of two new cases with non-paraneoplastic anti-Hu-associated gut motility impairment, and perform a thorough revision covering anti-Hu-associated paraneoplastic (PGID) and non-paraneoplastic (nPGID) gastrointestinal dysmotility.

Background: Several case series have clearly established a relationship between certain type of cancers, the development of circulating anti-Hu antibodies, and the concomitant usually severe gastrointestinal dysmotility; in contrast, a few studies focused on anti-Hu-associated nPGID.

Methods: We searched for studies regarding anti-Hu-associated gastrointestinal manifestations and extracted data concerning clinical characteristics of patients, including specific demographic, oncological, neurological, gastrointestinal, histological, and treatment response features. Read More

View Article and Full-Text PDF

Drug-Induced Pseudo-Central Serous Chorioretinopathy in Carcinoma Patients.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):403-409. Epub 2021 Apr 30.

Department of Ophthalmology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.

Purpose: Patients with carcinomas often share symptoms of vision deterioration as part of paraneoplastic retinopathy (PNR), based on a cross-reaction between antigens expressed by the underlying tumor and retinal proteins. However, some of the underlying symptoms may be explained by a drug-induced toxicity. The application of new therapeutic strategies with mitogen-activated protein kinase (MEK) and fibroblast growth factor receptor (FGFR) inhibitors in advanced cancers are still under evaluation for safety and tolerability, but also for dose-limiting toxicities. Read More

View Article and Full-Text PDF

Renal Diseases Associated with Hematologic Malignancies and Thymoma in the Absence of Renal Monoclonal Immunoglobulin Deposits.

Diagnostics (Basel) 2021 Apr 15;11(4). Epub 2021 Apr 15.

Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare "Syndrome Néphrotique Idiopathique", Fédération Hospitalo-Universitaire "Innovative Therapy for Immune Disorders", 94000 Créteil, France.

In addition to kidney diseases characterized by the precipitation and deposition of overproduced monoclonal immunoglobulin and kidney damage due to chemotherapy agents, a broad spectrum of renal lesions may be found in patients with hematologic malignancies. Glomerular diseases, in the form of paraneoplastic glomerulopathies and acute kidney injury with various degrees of proteinuria due to specific lymphomatous interstitial and/or glomerular infiltration, are two major renal complications observed in the lymphoid disorder setting. However, other hematologic neoplasms, including chronic lymphocytic leukemia, thymoma, myeloproliferative disorders, Castleman disease and hemophagocytic syndrome, have also been associated with the development of kidney lesions. Read More

View Article and Full-Text PDF

Clinical Spectrum, Therapeutic Outcomes and Prognostic predictors in Paraneoplastic Neurological Syndromes - Experiences from a Tertiary Care Center in India.

Ann Indian Acad Neurol 2021 Jan-Feb;24(1):32-39. Epub 2021 Feb 9.

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Paraneoplastic Neurological Syndromes (PNSs) are a heterogeneous group of immune-mediated disorders that often precede tumor diagnosis. There are few systematic studies on the spectrum and follow-up of PNSs.

Objective: To analyze the clinical spectrum, associated tumors, antibody profile, outcomes, and prognostic predictors in a cohort of PNSs admitted in a tertiary care center. Read More

View Article and Full-Text PDF
February 2021

Granulocyte Colony-stimulating Factor Producing Oropharyngeal Squamous Cell Carcinoma.

In Vivo 2021 May-Jun;35(3):1785-1790

Department of Medical Oncology, Biel-Bienne, Switzerland.

Case Report: We report on the case of a 47-year old woman with granulocyte colony-stimulating factor (G-CSF)-producing relapsed oropharyngeal squamous cell cancer. Palliative immunotherapy with nivolumab was started. Absolute neutrophilic count increased during the course of immunotherapy and correlated with tumour progression. Read More

View Article and Full-Text PDF
December 2020

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis: A case report.

Medicine (Baltimore) 2021 Apr;100(17):e25694

Aerospace Clinic Academy, Peking University Health Science Centre, Beijing, China.

Introduction: : Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a subtype of glutamate receptor that mediates most of the fast excitatory neurotransmission in the brain. Anti-AMPAR encephalitis is an autoimmune-mediated neurological disorder, frequently accompanied by the presence of neoplasms, comprising a spectrum of paraneoplastic syndrome.

Patient Concerns: A 56-year-old man was admitted for deterioration in memory and aberrant psychological behaviors, which lasted for at least 20 days. Read More

View Article and Full-Text PDF

Paraneoplastic Neuromyelitis Optica Spectrum Disorder Associated with Atypical Thymic Carcinoid: A Case Report.

Ann Thorac Cardiovasc Surg 2021 Apr 27. Epub 2021 Apr 27.

Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease, occasionally accompanied by malignant tumors. Immunosuppressive therapy is the mainstay treatment for idiopathic NMOSD; no guidelines have been published for paraneoplastic NMOSD because it is rarely reported in the literature. We report a rare case of a 67-year-old man with paraneoplastic NMOSD associated with thymic carcinoid whose cells expressed aquaporin-4 antibody. Read More

View Article and Full-Text PDF

[Dermatomyositis as a paraneoplastic syndrome of head-neck-cancer: Case series & literature review].

Laryngorhinootologie 2021 Apr 27. Epub 2021 Apr 27.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik für Hals-Nasen-Ohrenheilkunde, Campus Benjamin Franklin.

Introduction:  Dermatomyositis (DM) is a rare disease with the clinical manifestation of weakness and pain of proximal muscles as well as lilac-coloured skin lesions. One fifth of the cases is associated with the occurrence of a malignant tumor disease. The aim of this study is to evaluate the relevance of DM as a paraneoplastic syndrome in head and neck cancer taken into account the current literature. Read More

View Article and Full-Text PDF

The phosphaturic mesenchymal tumor as a cause of oncogenic osteomalacia. Three cases and review of the literature.

Rev Esp Cir Ortop Traumatol 2021 Apr 23. Epub 2021 Apr 23.

Servicio de Endocrinología y Nutrición, Hospital Ramón y Cajal, Madrid, España.

Introduction: The phosphaturic mesenchymal tumour (PMT) is a very uncommon cause of oncogenic osteomalacia (OO), which is a paraneoplastic syndrome with severe clinical osteomalacia. The PMT is a neoplasia that produces the fibroblast growth factor FGF23, resulting in reduced proximal tubular phosphate reabsorption leading to hyperphosphaturia and hypophosphatemia. Our aim is to present our experience and complications in diagnosis and treatment of PMT in three patients. Read More

View Article and Full-Text PDF

Autoimmune Neurologic Emergencies.

Neurol Clin 2021 05 31;39(2):589-614. Epub 2021 Mar 31.

Lahey Hospital & Medical Center, Beth Israel Lahey Health, 41 Mall Road, Burlington, MA 01803, USA.

Over the past decade, understanding of autoimmune neurologic disorders has exponentially increased. Many patients present as a neurologic emergency and require timely evaluation with rapid management and intensive care. However, the diagnosis is often either missed or delayed, which may lead to a significant burden of disabling morbidity and even mortality. Read More

View Article and Full-Text PDF

Myasthenia Gravis Related to Small Cell Lung Carcinoma.

Cureus 2021 Mar 14;13(3):e13889. Epub 2021 Mar 14.

Clinical Neurophysiology Department, La Princesa University Hospital, Madrid, ESP.

Myasthenia gravis is a neuromuscular disease that causes weakness in skeletal muscles because of the presence of acetylcholine receptor antibodies. These antibodies produce a compromise in the end-plate potential, reducing the safety factor for effective synaptic transmission. Clinically, this manifests as muscle weakness and, in severe cases, respiratory failure. Read More

View Article and Full-Text PDF

Presence of anti-TIF-1γ, anti-Ro52, anti-SSA/Ro60 and anti-Su/Ago2 antibodies in breast cancer: a cross-sectional study.

Immunopharmacol Immunotoxicol 2021 Apr 20:1-6. Epub 2021 Apr 20.

Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

Objectives: The presence of myositis-specific antibodies (MSA), was recently reported in healthy individuals, cancer patients without myopathy and paraneoplastic rheumatic syndromes. We sought to analyze the frequency of MSA, myositis-associated antibodies (MAA) and autoantibodies related to systemic autoimmune rheumatic diseases (SARD) in breast cancer patients.

Methods: One hundred fifty-two breast cancer patients were enrolled in a cross-sectional study. Read More

View Article and Full-Text PDF

Primary Takotsubo Syndrome as a Complication of Bladder Cancer Treatment in a 62-Year-Old Woman.

Am J Case Rep 2021 Apr 20;22:e930090. Epub 2021 Apr 20.

Department of Invasive Cardiology, Medical University in Białystok, Białystok, Poland.

BACKGROUND The main causes for takotsubo syndrome (TS) in oncological patients are stress related to cancer diagnosis and treatment, pain in the course of the disease, treatment complications, and paraneoplastic syndromes. CASE REPORT An obese 62-year-old female patient, with a 3-day history of chest pain, was admitted to the hospital with a suspected acute coronary event. She had been diagnosed with high-grade bladder cancer 6 months before. Read More

View Article and Full-Text PDF

Paraneoplastic ganglioradiculoneuritis in a cat with a plasma cell tumour.

JFMS Open Rep 2021 Jan-Jun;7(1):20551169211003806. Epub 2021 Mar 31.

Southfields Veterinary Specialists, Laindon, UK.

Case Summary: An 8-year-old neutered female domestic longhair cat was presented for investigation of a 48 h history of lethargy and pelvic limb ataxia. MRI of the spinal cord and vertebral column (C1 to sacrum) and brain was unremarkable. Lumbar cerebrospinal fluid analysis revealed pleocytosis and increased protein concentration. Read More

View Article and Full-Text PDF

Failure of IVIG in steroid-responsive autoimmune glial fibrillary acidic protein astrocytopathy: A case report.

Mult Scler Relat Disord 2021 Apr 4;51:102933. Epub 2021 Apr 4.

University of California Irvine (UCI), Department of Neurology, Irvine CA, United States.

Objective: To advocate for high-dose steroids, not intravenous immunoglobulins (IVIG), as first-line treatment for Anti-glial fibrillary acidic protein (GFAP) associated meningoencephalomyelitis.

Background: A novel IgG antibody against GFAP was associated with relapsing autoimmune meningoencephalomyelitis.

Design/methods: Here, we present an investigational case report to highlight continuing challenges in diagnosing and managing Anti-GFAP associated meningoencephalomyelitis. Read More

View Article and Full-Text PDF

Utility of 18F-AlF-NOTA-octreotide PET/CT in the localization of Tumor-Induced Osteomalacia.

J Clin Endocrinol Metab 2021 Apr 17. Epub 2021 Apr 17.

Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Purpose: Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder, usually caused by benign mesenchymal tumors that produce high levels of the hormone fibroblast-growth-factor 23 (FGF23). The only curative therapy of the disease is resection of the causative tumors. This research was conducted to evaluate the efficacy of 18F-AlF-NOTA-octreotide ( 18F-OC) PET/CT in detecting TIO and its impact on patient management. Read More

View Article and Full-Text PDF